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+############################
+#                          #
+# Variant Effect Predictor #
+#                          #
+############################
+
+Copyright (c) 1999-2011 The European Bioinformatics Institute and
+Genome Research Limited.  All rights reserved.
+
+This software is distributed under a modified Apache license.
+For license details, please see
+
+http://www.ensembl.org/info/about/code_licence.html
+
+Please email comments or questions to the public Ensembl
+developers list at <dev@ensembl.org>.
+
+Questions may also be sent to the Ensembl help desk at
+<helpdesk@ensembl.org>
+  
+Quickstart
+==========
+
+Install API and cache files, run in offline mode:
+
+perl INSTALL.pl
+perl variant_effect_predictor.pl --offline
+
+
+Documentation
+=============
+
+For a summary of command line flags, run:
+
+perl variant_effect_predictor.pl --help
+
+For full documentation see
+
+http://www.ensembl.org/info/docs/variation/vep/vep_script.html
+
+
+
+Changelog
+=========
+
+New in version 2.6 (July 2012)
+------------------------------
+
+- support for structural variant consequences
+
+- Sequence Ontology (SO) consequence terms now default
+
+- script runtime 3-4x faster when using forking
+
+- 1000 Genomes global MAF available in cache files
+
+- improved memory usage
+
+
+New in version 2.5 (May 2012)
+-----------------------------
+
+- SIFT and PolyPhen predictions now available for RefSeq transcripts
+
+- retrieve cell type-specific regulatory consequences
+
+- consequences can be retrieved based on a single individual's genotype in
+  a VCF input file
+
+- find overlapping structural variants
+
+- Condel support removed from main script and moved to a plugin
+
+
+New in version 2.4 (February 2012)
+----------------------------------
+- offline mode and new installer script make it easy to use the VEP without
+  the usual dependencies
+
+- output columns configurable using the --fields flag
+
+- VCF output support expanded, can now carry all fields
+
+- output affected exon and intron numbers with --numbers
+
+- output overlapping protein domains using --domains
+
+- enhanced support for LRGs
+
+- plugins now work on variants called as intergenic
+
+
+New in version 2.3 (December 2011)
+----------------------------------
+
+- Add custom annotations from tabix-indexed files (BED, GFF, GTF, VCF, bigWig)
+
+- Add new functionality to the VEP with user-written plugins
+
+- Filter input on consequence type
+
+
+Version 2.2 (September 2011)
+----------------------------
+
+- SIFT, PolyPhen and Condel predictions and regulatory features now accessible
+  from the cache
+
+- Support for calling consequences against RefSeq transcripts
+
+- Variant identifiers (e.g. dbSNP rsIDs) and HGVS notations supported as input
+  format
+
+- Variants can now be filtered by frequency in HapMap and 1000 genomes
+  populations
+
+- Script can be used to convert files between formats (Ensembl/VCF/Pileup/HGVS
+  to Ensembl/VCF/Pileup)
+
+- Large amount of code moved to API modules to ensure consistency between web
+  and script VEP
+  
+- Memory usage optimisations
+
+- VEP script moved to ensembl-tools CVS module
+
+- Added --canonical, --per_gene and --no_intergenic options
+
+
+Version 2.1 (June 2011)
+-----------------------
+
+- ability to use local file cache in place of or alongside connecting to an
+  Ensembl database
+
+- significant improvements to speed of script
+
+- whole-genome mode now default (no disadvantage for smaller datasets)
+
+- improved status output with progress bars
+
+- regulatory region consequences now reinstated and improved
+
+- modification to output file - Transcript column is now Feature, and is
+  followed by a Feature_type column
+  
+- full documentation now online
+
+
+Version 2.0 (April 2011)
+------------------------
+
+Version 2.0 of the Variant Effect Predictor script (VEP) constitutes a complete
+overhaul of both the script and the API behind it. It requires at least version
+62 of the Ensembl API to function. Here follows a summary of the changes:
+
+- support for SIFT, PolyPhen and Condel non-synonymous predictions in human
+
+- per-allele and compound consequence types
+
+- support for Sequence Ontology (SO) and NCBI consequence terms
+
+- modified output format
+  - support for new output fields in Extra column
+  - header section containing information on database and software versions
+  - codon change shown in output
+  - CDS position shown in output
+  - option to output Ensembl protein identifiers
+  - option to output HGVS nomenclature for variants
+  
+- support for gzipped input files
+  
+- enhanced configuration options, including the ability to read configuration
+  from a file
+
+- verbose output now much more useful
+
+- whole-genome mode now more stable
+
+- finding existing co-located variations now ~5x faster