Mercurial > repos > bimib > cobraxy
diff COBRAxy/flux_simulation.xml @ 7:515cd9e4f518 draft
Uploaded
author | luca_milaz |
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date | Wed, 18 Sep 2024 12:09:06 +0000 |
parents | 41f35c2f0c7b |
children | 5a69dd906256 |
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--- a/COBRAxy/flux_simulation.xml Wed Sep 18 12:00:49 2024 +0000 +++ b/COBRAxy/flux_simulation.xml Wed Sep 18 12:09:06 2024 +0000 @@ -99,26 +99,28 @@ What it does ------------- -This tool generates flux samples starting from a model in JSON or XML format by using CBS (Corner-based sampling) and OPTGP (mproved Artificial Centering Hit-and-Run sampler) sampling algorithms. +This tool generates flux samples starting from a model in JSON or XML format by using CBS (Corner-based sampling) or OPTGP (mproved Artificial Centering Hit-and-Run sampler) sampling algorithms. + It can return sampled fluxes by appliying summary statistics: - - mean - - median - - quantiles (0.25, 0.50, 0.75). + - mean + - median + - quantiles (0.25, 0.50, 0.75). + Moreover, flux analysis can be perfomed over the metabolic model: - - parsimoniuos-FBA (optimized by Biomass) - - FVA - - Biomass sensitivity analysis (single reaction knock-out). It the ratio between the optimal FBA coefficients of the Biomass reaction after knocking-out a reaction and the same over the complete model. + - parsimoniuos-FBA (optimized by Biomass) + - FVA + - Biomass sensitivity analysis (single reaction knock-out). It is the ratio between the optimal of the Biomass reaction computed by FBA after knocking-out a reaction and the same over the complete model. Accepted files: - - A model: JSON or XML file reporting reactions and rules contained in the model. It can be a single model, multiple models or a collection of models. - - Cell-specific bounds: generated by RAS to Bounds tool. + - A model: JSON or XML file reporting reactions and rules contained in the model. It can be a single model, multiple models or a collection of models. + - Cell-specific bounds: generated by RAS to Bounds tool. Output: ------------- The tool generates: - - Samples: reporting the sampled fluxes for each reaction. Format: csv. - - a log file (.txt). + - Samples: reporting the sampled fluxes for each reaction. Format: csv. + - a log file (.txt). **TIP**: The Batches parameter is useful to mantain in memory just a batch of samples at time. For example, if you wish to sample 10.000 points, than it is suggested to select n_samples = 1.000 and n_batches=10.