Mercurial > repos > bimib > cobraxy
view COBRAxy/local/svg metabolic maps/ENGRO2_map.svg @ 181:be42b8755313 draft
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| author | francesco_lapi |
|---|---|
| date | Wed, 20 Nov 2024 15:50:36 +0000 |
| parents | c5b17211bb02 |
| children | 851b5ad6bb2a |
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<?xml version="1.0" encoding="UTF-8" standalone="no"?> <svg width="2632" height="2412" viewBox="0 0 2632 2412" fill="none" version="1.1" id="svg5792" sodipodi:docname="ENGRO2_map.svg" inkscape:version="1.3 (0e150ed6c4, 2023-07-21)" xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape" xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd" xmlns="http://www.w3.org/2000/svg" xmlns:svg="http://www.w3.org/2000/svg"> <defs id="defs5796" /> <sodipodi:namedview id="namedview5794" pagecolor="#ffffff" bordercolor="#000000" borderopacity="0.25" inkscape:showpageshadow="2" inkscape:pageopacity="0.0" inkscape:pagecheckerboard="0" inkscape:deskcolor="#d1d1d1" showgrid="false" inkscape:zoom="1.9442505" inkscape:cx="1330.0755" inkscape:cy="262.56905" inkscape:window-width="1920" inkscape:window-height="1009" inkscape:window-x="-8" inkscape:window-y="-8" inkscape:window-maximized="1" inkscape:current-layer="ENGRO2_2" /> <rect width="2632" height="2412" fill="#f5f5f5" id="rect2" x="77.664886" y="27.259863" /> <path id="F_PYRt2" fill-rule="evenodd" clip-rule="evenodd" d="m 59.931061,1002.2259 -9.419058,-2.9576 9.419058,-2.95659 -2.354765,2.95659 z" stroke="#000000" stroke-width="2.84525" /> <g id="ENGRO2_2"> <g id="Legend"> <text id="text39" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="32" font-weight="bold" letter-spacing="0em"><tspan x="98.2344" y="2289.59" id="tspan4">Legend:</tspan></text> <g id="Legend body"> <text id="text35" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="220.246" y="2350.32" id="tspan7">= Up regulated</tspan></text> <text id="text37" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="220.07" y="2405.32" id="tspan10">= Down regulated</tspan></text> <path id="path6613-3" d="M98 2397H210" stroke="#0000FF" stroke-width="30" /> <path id="path6613-8-6" d="M98 2342H210" stroke="#E41A1C" stroke-width="30" /> <path id="path6613-8-1-0" d="M485 2397H597" stroke="#BEBEBE" stroke-width="30" /> <g id="path6613-8-4-9"> <path d="M1040 2342H1152H1040Z" fill="black" id="path16" /> <path d="M1040 2342H1152" stroke="black" stroke-width="30" id="path18" /> </g> <path id="path6613-8-2-6" d="M485 2342H597" stroke="#BEBEBE" stroke-width="30" stroke-dasharray="30 30" /> <text id="text46" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="1167.06" y="2350.32" id="tspan22">= Not classified</tspan></text> <text id="text48" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="609.25" y="2350.32" id="tspan25">= Not significant</tspan></text> <text id="text50" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="609.16" y="2405.32" id="tspan28">= Fold change under threshold</tspan></text> <text id="text52" fill="black" xml:space="preserve" style="white-space: pre" font-family="Arial" font-size="24" font-weight="bold" letter-spacing="0em"><tspan x="1038.43" y="2405.32" id="tspan31">Thickness is proportional to fold change</tspan></text> </g> </g> <g id="Group 141" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> <g id="R_t_Lcystin_leu__L" inkscape:label="R_t_Lcystin_leu__L"> <path fill-rule="evenodd" clip-rule="evenodd" d="m 88.3713,1562.09 c 7.4462,-1.84 5.8622,-17.09 5.8622,-17.09 z M 46.0479,1563 h 75.0001 z m 14.5213,-17.82 c -3.1784,10.78 6.0234,17.13 6.0234,17.13 z" fill="#2b0000" id="path36" inkscape:label="R_t_Lcystin_leu__L" /> <path d="m 88.3713,1562.09 c 7.4462,-1.84 5.8622,-17.09 5.8622,-17.09 m -48.1857,18 h 75.0002 m -60.4788,-17.82 c -1.125229,3.8164 -0.698813,7.0775 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-5.37,-12 -12,-12 H 2282.6 1523 c -6.63,0 -12,5.373 -12,12 v 246 c 0,6.627 5.37,12 12,12 h 835 c 6.63,0 12,-5.373 12,-12 z" fill="#cbe048" fill-opacity="0.1" /> <path id="Rectangle 2_4" d="m 1870,705 h 475.5 c 6.63,0 12,5.373 12,12 v 246.5 c 0,6.627 -5.37,12 -12,12 H 1511 c -6.63,0 -12,-5.373 -12,-12 V 717 c 0,-6.627 5.37,-12 12,-12 h 8.5" stroke="#cbe048" stroke-width="4" stroke-linecap="round" /> <text id="Title_4" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="20px" font-weight="bold" letter-spacing="0em"><tspan x="1528" y="711.43402" id="tspan728">Fatty acids / Cholesterol synthesis</tspan></text> <circle id="Ellipse 1_4" cx="1869" cy="705" r="6" fill="#cbe048" /> </g> <g id="path_urea_cycle" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> <path id="Rectangle 3_5" d="M 1850,669 V 510 c 0,-6.627 -5.37,-12 -12,-12 H 1815.51 1523 c -6.63,0 -12,5.373 -12,12 v 159 c 0,6.627 5.37,12 12,12 h 315 c 6.63,0 12,-5.373 12,-12 z" 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id="tspan756">Fatty acids β-oxidation </tspan></text> <circle id="Ellipse 1_8" cx="1564" cy="1737" r="6" fill="#cbe048" /> </g> <g id="path_glutathione" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> <path id="Rectangle 3_9" d="m 2571,2212 v -108 c 0,-6.63 -5.37,-12 -12,-12 H 2522.77 2109 c -6.63,0 -12,5.37 -12,12 v 108 c 0,6.63 5.37,12 12,12 h 450 c 6.63,0 12,-5.37 12,-12 z" fill="#aeaeae" fill-opacity="0.1" /> <path id="Rectangle 2_9" d="m 2330.5,2079 h 216 c 6.63,0 12,5.37 12,12 v 109 c 0,6.63 -5.37,12 -12,12 H 2097 c -6.63,0 -12,-5.37 -12,-12 v -109 c 0,-6.63 5.37,-12 12,-12 h 8.5" stroke="#aeaeae" stroke-width="4" stroke-linecap="round" /> <text id="Title_9" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="20px" font-weight="bold" letter-spacing="0em"><tspan x="2114" y="2085.4299" id="tspan763">Glutathione synthesis</tspan></text> <circle id="Ellipse 1_9" cx="2334" cy="2079" r="6" fill="#aeaeae" /> </g> <g 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id="tspan2369">AcAcCoA</tspan></text> <path id="F_HMGCOAS" d="m 1619.32,928.248 -1.47,-5.596 -1.11,5.65 1.24,-1.433 z m 87.44,8.733 5.84,-1.962 -5.97,-1.524 1.54,1.688 z" stroke="#000000" stroke-width="2.23952" /> <path id="R_HMGCOAS" d="m 1607,935.475 h 100.5 m -93.23,8.722 c 0,0 -2.66,-7.719 2.23,-8.722 5.05,-0.886 1.34,-7.755 1.34,-7.755 m 49.1,7.755 c -4.89,1.003 -4.47,8.43 -4.47,8.43" stroke="#000000" stroke-width="1.77188" /> </g> <g id="Group 72"> <text id="PalmCoA" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2195.4099" y="739.547" id="tspan2375">PalmCoA</tspan></text> <text id="text7967-0-3-65-5-3-5-1-2-8-1-2" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="2242.3201" y="802.15997" id="tspan2378">CoA</tspan></text> <text id="text7967-0-3-65-5-3-5-1-2-8-8-7" fill="#000000" xml:space="preserve" 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letter-spacing="0em"><tspan x="2188.1399" y="957.15997" id="tspan2503">13 NADPH</tspan></text> <g id="text6997-5-1-8-3-71-2-7"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2508"><tspan x="2171.1799" y="957.15997" id="tspan2506">2</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2512"><tspan x="2145.1399" y="957.15997" id="tspan2510">10 O</tspan></text> </g> <g id="text6997-5-1-8-3-7-7-9"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2517"><tspan x="2267.3701" y="917.15997" id="tspan2515">13 NADP</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2521"><tspan x="2317.4199" y="917.15997" id="tspan2519">⁺</tspan></text> </g> 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font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2306.21" y="940.547" id="tspan2539">Chol</tspan></text> <text id="text7967-5" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="2255.3301" y="957.15997" id="tspan2542">fPP</tspan></text> <g id="text6997-5-1-8-3-71-5-6-1"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2549"><tspan x="2216.03" y="917.15997" id="tspan2545">15 H</tspan><tspan x="2245.6299" y="917.15997" id="tspan2547">O</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2554"><tspan x="2241.3999" y="917.15997" id="tspan2551">₂</tspan></text> </g> <path id="F_DSMSTOLR" d="m 2296.59,937.274 c 5.84,-1.962 5.84,-1.962 5.84,-1.962 l -5.97,-1.524 1.54,1.689 z m -199.01,-11.328 c 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<text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2561"><tspan x="2103.21" y="957.15997" id="tspan2559">16 H</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2565"><tspan x="2128.5801" y="957.15997" id="tspan2563">⁺</tspan></text> </g> </g> <text id="text6997-5-1-8" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1429" y="854.203" id="tspan2569">AcCoA</tspan></text> <g id="Group 80"> <text id="text7122_2" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1716.38" y="1068.55" id="tspan2572">HMGCoA</tspan></text> <path id="F_HMGCOAtm" d="M 1746.49,951.86 C 1744.6,946 1744.6,946 1744.6,946 l -1.6,5.942 1.71,-1.516 z" stroke="#000000" stroke-width="2.66667" /> <path id="R_HMGCOAtm" d="M 1745,1047 V 951" stroke="#000000" stroke-width="1.40903" /> <path id="B_HMGCOAtm" d="m 1743,1047.15 c 2.45,3.85 2.45,3.85 2.45,3.85 l 1.55,-4 -1.89,1.06 z" stroke="#000000" stroke-width="2.66667" /> </g> <g id="Group 81"> <text id="text7096" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1543.3199" y="867.15997" id="tspan2579">AcCoA</tspan></text> <text id="text7126" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1524.3199" y="903.15997" id="tspan2582">CoA</tspan></text> <path id="F_ACACT1r" d="m 1544.57,885.774 c -4.71,3.345 -4.71,3.345 -4.71,3.345 l 2.77,-5.046 0.04,1.9 z m 41.93,33.726 c 1.5,2.797 1.5,6.5 1.5,6.5 l -3.99,-3.703 2.16,-0.551 z" stroke="#000000" stroke-width="2.23952" /> <path id="R_ACACT1r" d="m 1543.25,885.667 c 0,0 6.79,-3.904 4.26,-7.167 -2.54,-3.263 4.42,-9 4.42,-9 m -66.93,-16 c 0,0 68,8.5 100.5,68" stroke="#000000" stroke-width="1.91333" /> </g> </g> <g id="Group 26" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> <g id="Group 157"> <g id="text6979-5-4-1-7-9-30-5-8-5-57-7-5-3"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text2591"><tspan x="1457.61" y="983.547" id="tspan2589">3</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text2595"><tspan x="1434.48" y="983.547" id="tspan2593">NH</tspan></text> </g> <path id="B_NH4tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1451.41,995.378 c -1.64,-5.367 -1.64,-5.367 -1.64,-5.367 l -1.76,5.328 1.71,-1.317 z" stroke="#000000" stroke-width="2.61244" /> <path id="R_NH4tm" d="m 1493,1136.5 h -43.55 V 996" stroke="#000000" stroke-width="1.74956" /> <path id="F_NH4tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1493.39,1138.38 c 5.12,-2.31 5.12,-2.31 5.12,-2.31 l -5.51,-1.07 1.52,1.54 z" stroke="#000000" stroke-width="2.61244" /> </g> <text id="text7967-0-3-6-2-7-4-34-0-4-2-9-0" transform="translate(1771,1126)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.49218801" y="14.5469" id="tspan2602">Ci</tspan></text> <g id="Group 64"> <g id="text7967-0-3-6-2-7-4-34-0-4-2-9"> <text transform="translate(1502,1126)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text2607"><tspan x="23.6094" y="14.5469" id="tspan2605">3</tspan></text> <text transform="translate(1502,1126)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text2611"><tspan x="0.484375" y="14.5469" id="tspan2609">NH</tspan></text> </g> <g id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8"> <text transform="translate(1568,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2616"><tspan x="0.0617189" y="11.1602" id="tspan2614">H</tspan></text> <text transform="translate(1568,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2620"><tspan x="8.7335901" y="11.1602" id="tspan2618">⁺</tspan></text> </g> <g id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-3"> <text transform="translate(1527,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2625"><tspan x="31.2549" y="11.1602" id="tspan2623">⁻</tspan></text> <text transform="translate(1527,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2629"><tspan x="27.031099" y="11.1602" id="tspan2627">₃</tspan></text> <text transform="translate(1527,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2633"><tspan x="0.347469" y="11.1602" id="tspan2631">HCO</tspan></text> </g> <text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-0" transform="translate(1660,1152)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.484375" y="11.1602" id="tspan2636">2 ADP</tspan></text> <text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-0_2" transform="translate(1638,1152)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.162109" y="11.1602" id="tspan2639">Pi</tspan></text> <path id="F_CBPSam" d="m 1675.5,1144 1.84,5.5 1.66,-5.5 -1.66,1 z m 11.63,-6.69 c 7.76,-1.83 7.76,-1.83 7.76,-1.83 l -7.98,-1.33 2.08,1.52 z" stroke="#000000" stroke-width="2.23952" /> <path id="R_CBPSam" d="m 1552.5,1135.29 c -6.5,0 -8,9.86 -8,9.86 m 38,-9.86 c -8,0 -9,9.86 -9,9.86 m 96,-9.86 c 7.5,0 7.5,9.86 7.5,9.86 m -66.5,-9.86 c -7.5,0 -9.5,9.86 -9.5,9.86 m 87.89,-9.86 c 0,0 -37.14,0 -53.89,0 m -96.5,0 c 0,0 67.41,0 96.5,0 m 0,0 c 8.5,0 8.5,9.86 8.5,9.86" stroke="#000000" stroke-width="2.08671" /> <text id="text3764" transform="translate(1586,1145)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.097656198" y="11.1602" id="tspan2644">2 ATP</tspan></text> </g> <text id="text4999" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1796.49" y="1161.16" id="tspan2648">Orn</tspan></text> <g id="text5007"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2653"><tspan x="1826.0601" y="1161.16" id="tspan2651">H</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2657"><tspan x="1834.73" y="1161.16" id="tspan2655">⁺</tspan></text> </g> <path id="F_ORNt4m" d="m 1826.5,1144.5 1.5,2.5 0.5,-3 -1,1 z m -18.5,-1 1,3 1,-3 -1,0.5 z m 106,-7 3.5,-1.5 -4,-1 1,1.5 z" stroke="#000000" stroke-width="2.23952" /> <text id="text5023" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1878.49" y="1154.16" id="tspan2661">Orn</tspan></text> <g id="text5031"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2666"><tspan x="1906.0601" y="1154.16" id="tspan2664">H</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text2670"><tspan x="1914.73" y="1154.16" id="tspan2668">⁺</tspan></text> </g> <path id="R_ORNt4m" d="m 1902.5,1135.21 c 7,0 7.5,8.79 7.5,8.79 m -29,-8.79 c 7.5,0 8.5,8.79 8.5,8.79 m -71,-8.79 c 9,0 9,8.79 9,8.79 m -28.5,-8.79 c 10,0 10,8.79 10,8.79 m -19,-8.79 h 126.5" stroke="#000000" stroke-width="2.08963" /> <text id="text5087" transform="translate(1923,1126)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.49218801" y="14.5469" id="tspan2674">Ci</tspan></text> <g id="Group 63"> <text id="text7967-0-3-6-2-7-4-34-0-4-2-9-8" transform="translate(1698,1126)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.38281199" y="14.5469" id="tspan2677">CP</tspan></text> <text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8-8" fill="#000000" xml:space="preserve" style="white-space:pre" 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stroke="#000000" stroke-width="2.66667" /> <path id="R_PPCOAtm" d="m 698.61,1115.59 55.323,0.67" stroke="#000000" stroke-width="1.59033" /> <path id="B_PPCOAtm" d="m 700.452,1112.53 c -9.775,2.74 -9.775,2.74 -9.775,2.74 l 9.692,3.01 -2.392,-2.91 z" stroke="#000000" stroke-width="2.66667" /> </g> <g id="Group 41"> <text id="text4809-3-0" transform="rotate(0.11511,-609938.9,299279.65)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.28125" y="14.5469" id="tspan4274">5,10meTHF</tspan></text> <text id="text4809-9-0-1" transform="rotate(0.11511,-609855.9,381905.8)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.28125" y="14.5469" id="tspan4277">5,10meTHF</tspan></text> <path id="F_MLTHFtm" d="m 750.829,1239.14 c 9.671,-3.08 9.671,-3.08 9.671,-3.08 l -9.792,-2.68 2.493,2.83 z" stroke="#000000" stroke-width="2.66667" /> <path id="R_MLTHFtm" d="m 697.477,1235.38 55.323,0.68" stroke="#000000" stroke-width="1.59033" /> <path id="B_MLTHFtm" d="m 699.319,1232.33 c -9.774,2.73 -9.774,2.73 -9.774,2.73 l 9.691,3.02 -2.391,-2.91 z" stroke="#000000" stroke-width="2.66667" /> </g> <g id="Group 58"> <text id="text7967-0-3-65-1-3-2-82-8-8" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1043.33" y="1184.16" id="tspan4284">AKG</tspan></text> <text id="text7967-0-3-65-1-3-2-5-0-5-7" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1050.15" y="1213.16" id="tspan4287">Glu</tspan></text> <g id="B_ASPTAm"> <path d="m 1081.5,1207 -1,2 1,2.5 -6.5,-1.5 z" stroke="#000000" stroke-width="2.23952" id="path4290" /> <path d="m 1096,1404 3.5,2 2.5,-1 -2.5,10 z" stroke="#000000" stroke-width="2.23952" id="path4292" /> </g> <path id="F_ASPTAm" d="m 1095,1152.5 3,-7.5 4,7.5 c 0,0 -3.02,-2.22 -4,-3 z" stroke="#000000" stroke-width="2.23952" stroke-miterlimit="5.75877" /> <path id="R_ASPTAm" d="m 1099,1150 v 256 m -17,-197.48 c 0,0 17,3.06 17,-14.63 0,0 0,-12.25 -17,-12.25" stroke="#000000" stroke-width="2.25114" /> <text id="text7967-0-3-0-2-6-3-0-6" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1083.38" y="1133.55" id="tspan4297">Asp</tspan></text> <text id="text7967-0-3-9-1-2-1-3-4-7-1" transform="translate(1052,962)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.156251" y="14.5469" id="tspan4300">Glu</tspan></text> <g id="text7967-0-3-9-1-2-1-3-8-9-5"> <text transform="translate(1056.15,1038.51)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4305"><tspan x="0.41562501" y="14.5469" id="tspan4303">H</tspan></text> <text transform="translate(1056.15,1038.51)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4309"><tspan x="11.9781" y="14.5469" id="tspan4307">⁺</tspan></text> </g> <g id="text7967-0-3-9-1-2-1-3-8-9-5-0"> <text transform="translate(1061,993)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4314"><tspan x="0.41562501" y="14.5469" id="tspan4312">H</tspan></text> <text transform="translate(1061,993)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4318"><tspan x="11.9781" y="14.5469" id="tspan4316">⁺</tspan></text> </g> <text id="text7967-0-3-9-1-2-1-3-4-8-3-9" transform="translate(1049,1058)" 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-9.22,2.82 -9.22,2.82 l 9.15,3.03 -2.26,-2.95 z" stroke="#000000" stroke-width="2.23952" /> <path id="R_ACACT1m" d="m 1367.32,2041.75 h 33.25 m -22.08,0.15 c 7.09,-1.89 6.27,-20.61 6.27,-20.61" stroke="#000000" stroke-width="1.57473" /> <text id="text4203" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="1373.3199" y="2018.16" id="tspan4332">CoA</tspan></text> <text id="text4207" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1288.4301" y="2045.55" id="tspan4335">2 AcCoA</tspan></text> <path id="F_HACD1m" d="m 1492.61,2036.41 c -9.61,3.25 -9.61,3.25 -9.61,3.25 l 9.84,2.5 -2.54,-2.78 z m 10.89,-10.91 -1.5,-4.5 -1.5,4.5 1.5,-0.5 z" stroke="#000000" stroke-width="2.66667" /> <path id="R_HACD1m" d="M 1579.5,2039.24 C 1595,2039.18 1595,2026 1595,2026 m -103.17,13.58 c 0,0 12.6,-0.05 20.67,-0.08 m 107.34,-0.42 c 0,0 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stroke-width="1.1381" id="path4370" /> </g> </g> <g id="use1272-2-48"> <path id="circle77227-5-9" d="m 1561.38,1925.76 c 6.29,0 11.38,-5.09 11.38,-11.38 0,-6.28 -5.09,-11.38 -11.38,-11.38 -6.28,0 -11.38,5.1 -11.38,11.38 0,6.29 5.1,11.38 11.38,11.38 z" fill="#aaccee" stroke="#000000" stroke-width="1.1381" /> <g id="path77229-7-3"> <path d="m 1553.41,1906.41 15.94,15.94 z" fill="#aaccee" id="path4375" /> <path d="m 1553.41,1906.41 15.94,15.94" stroke="#000000" stroke-width="1.1381" id="path4377" /> </g> <g id="path77231-8-4"> <path d="m 1553.41,1922.35 15.94,-15.94 z" fill="#aaccee" id="path4380" /> <path d="m 1553.41,1922.35 15.94,-15.94" stroke="#000000" stroke-width="1.1381" id="path4382" /> </g> </g> <text id="text14626" transform="translate(1421.02,1905.07)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="0.375" y="14.5469" id="tspan4386">HMGCoA</tspan></text> <text id="text14626-4" 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1790.93,35.6484 1787.96,26 l -2.96,9.6484 2.96,-2.4122 z" stroke="#000000" stroke-width="2.32327" /> </g> </g> <g id="Group 145"> <path id="F_NH4t" fill-rule="evenodd" clip-rule="evenodd" d="m 1807.89,35.2407 -2.95,-9.2406 -2.94,9.2406 2.94,-2.3101 z" stroke="#000000" stroke-width="3.3745" /> <path id="R_NH4t" d="M 1805.39,531.5 V 30.5" stroke="#000000" stroke-width="2.28" /> <g id="M_Glc-8-6-7-8"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4482"><tspan x="1820.61" y="547.547" id="tspan4480">3</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em" id="text4486"><tspan x="1797.48" y="547.547" id="tspan4484">NH</tspan></text> </g> </g> </g> <g id="Group 30" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> <text id="PalmCarn" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1935" y="1802.3199" id="tspan4491">PalmCarn</tspan></text> <text id="PalmCarn_2" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1717" y="1802.3199" id="tspan4494">PalmCarn</tspan></text> <path id="R_CARN160t_m" d="m 1919.03,1797.01 h -112 m 100.47,15.65 c -4.5,-13.16 -12.5,-15.65 -12.5,-15.65 m -57.5,0 c -14,0 -10.5,15.65 -10.5,15.65" stroke="#000000" stroke-width="2.69741" /> <path id="B_CARN160t_m" d="m 1825.5,1813 3,3 1,-4.5 -2,1.5 z m 92.87,-13.91 c 8.63,-2.34 8.63,-2.34 8.63,-2.34 l -8.51,-2.75 2.08,2.59 z" stroke="#000000" stroke-width="2.23952" /> <path id="F_CARN160t_m" d="m 1809.49,1795 c -7.49,2.67 -7.49,2.67 -7.49,2.67 l 7.68,2 -1.99,-2.25 z m 96.51,18.5 4,3.5 -0.5,-5 -1.5,1.5 z" stroke="#000000" stroke-width="2.23952" /> <text 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stroke="#000000" stroke-width="2.23952" /> <path id="R_carnitineAcylTransferaseII" d="m 1663.06,1797.28 41,-0.43 m -20.65,0.15 c 6.32,-1.58 5.59,-17.1 5.59,-17.1 m -13.9,-1.6 c -3.04,11.66 4.4,19 4.4,19" stroke="#000000" stroke-width="2.23952" /> <path id="B_carnitineAcylTransferaseII" d="m 1691.81,1782.38 c -1.79,-8.08 -1.79,-8.08 -1.79,-8.08 l -1.96,8.01 1.9,-1.98 z m 10.85,16.92 c 8.4,-2.98 8.4,-2.98 8.4,-2.98 l -8.7,-1.99 2.29,2.36 z" stroke="#000000" stroke-width="2.23952" /> <text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8-54-0-8-2-6-6" transform="translate(1654,1760.01)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.48632801" y="11.1602" id="tspan4512">Carn</tspan></text> <text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8-54-0-2-2-5-6" transform="translate(1684,1759)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.32226601" y="11.1602" id="tspan4515">CoA</tspan></text> <text id="text7967-0-3-9-14-8-1-9-3-4-5" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="1324.4301" y="1803.55" id="tspan4518">8 AcCoA</tspan></text> <text id="text7967-0-3-65-5-3-5-1-2-8-1-2-5" transform="rotate(0.250513,-404506.17,354948.12)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.31835899" y="11.1602" id="tspan4521">7 FAD</tspan></text> <g id="text7967-0-3-65-5-3-5-1-2-8-1-2-56"> <text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4526"><tspan x="0.21406201" y="11.1602" id="tspan4524">7 NAD</tspan></text> <text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4530"><tspan x="35.5812" y="11.1602" id="tspan4528">⁺</tspan></text> </g> <text id="text7967-0-3-65-5-3-5-1-2-8-1-2-8" transform="rotate(0.250513,-404553.17,333449.05)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.3125" y="11.1602" id="tspan4533">7 CoA</tspan></text> <g id="text7967-0-3-65-5-3-5-1-2-8-1-2-6"> <text transform="rotate(0.250513,-404577.17,322470.81)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4540"><tspan x="0.37246901" y="11.1602" id="tspan4536">7 H</tspan><tspan x="23.287701" y="11.1602" id="tspan4538">O</tspan></text> <text transform="rotate(0.250513,-404577.17,322470.81)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4544"><tspan x="19.0639" y="11.1602" id="tspan4542">₂</tspan></text> </g> <path id="R_betaOxidation" d="m 1464,1797.76 c 7.43,-0.51 7,-11.69 7,-11.69 m 50,0 c 0,0 -3.07,11.18 -10.5,11.69 -6.86,1.19 -7.66,15.24 -7.66,15.24 m 62.29,-26.93 c 0,0 -3.52,11.18 -10.95,11.69 -6.86,1.19 -9.79,15.24 -9.79,15.24 m -142.89,-15.24 h 175 m -163.5,0 c 7.43,-0.51 9,-11.69 9,-11.69 m 37,11.69 c -6.86,1.19 -7.16,15.24 -7.16,15.24" stroke="#000000" stroke-width="1.7215" /> <g id="text7967-0-3-65-5-3-5-1-2-8-1-2-5-0"> <text transform="rotate(0.250513,-415155.64,349482.25)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4550"><tspan x="0.47851601" y="11.1602" id="tspan4548">7 FADH</tspan></text> <text transform="rotate(0.250513,-415155.64,349482.25)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4554"><tspan x="42.513699" y="11.1602" id="tspan4552">₂</tspan></text> </g> <text id="text7967-0-3-65-5-3-5-1-2-8-1-2-56-5" transform="rotate(0.250513,-415202.14,328211.9)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="0.48046899" y="11.1602" id="tspan4557">7 NADH</tspan></text> <g id="text7967-0-3-65-5-3-5-1-2-8-1-2-6-2"> <text transform="rotate(0.250513,-415171.64,342163.42)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4562"><tspan x="0.051953301" y="11.1602" id="tspan4560">7 H</tspan></text> <text transform="rotate(0.250513,-415171.64,342163.42)" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4566"><tspan x="18.743401" y="11.1602" id="tspan4564">⁺</tspan></text> </g> <path id="F_betaOxidation" d="m 1450.52,1808.51 c 0.84,8.49 0.84,8.49 0.84,8.49 l 2.9,-7.97 -2.13,1.8 z m 51.1,0 c 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5.88,-20.34 m -14.5,21.25 c -7.97,2.41 -7.29,20.3 -7.29,20.3" stroke="#000000" stroke-width="2.1163" /> <g id="text7967-0-3-9-1-2-1-3-9-7"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4608"><tspan x="2332.3799" y="2056.1599" id="tspan4604">H</tspan><tspan x="2345.28" y="2056.1599" id="tspan4606">O</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4612"><tspan x="2341.05" y="2056.1599" id="tspan4610">₂</tspan></text> </g> <path id="F_HCO3E" d="m 2368.22,2005.03 c -1.78,-9.37 -1.78,-9.37 -1.78,-9.37 l -2.48,9.17 2.22,-2.22 z m 10.66,19.84 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.8,-2.65 2.5,2.82 z" stroke="#000000" stroke-width="2.23952" /> <text id="text4057" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2239.1001" y="2027.55" id="tspan4616">ADP</tspan></text> <text id="text4065-4" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="2182.8201" y="1996.03" id="tspan4619">Pi</tspan></text> <g id="text4073-2"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4626"><tspan x="2131.25" y="1995.97" id="tspan4622">H</tspan><tspan x="2144.1399" y="1995.97" id="tspan4624">O</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4630"><tspan x="2139.9199" y="1995.97" id="tspan4628">₂</tspan></text> </g> <text id="text4077" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2089.0901" y="2027.55" id="tspan4633">ATP</tspan></text> <path id="R_ATPM" d="m 2184.01,2022.45 c 7.16,-1.67 6.53,-18.98 6.53,-18.98 m -67.04,19.69 102.91,-0.4 m -20.4,-0.31 c 7.16,-1.67 6.53,-18.98 6.53,-18.98 m -63.68,-1.55 c -3.59,12.96 4.73,21.24 4.73,21.24" stroke="#000000" stroke-width="3.03597" /> <path id="F_ATPM" d="m 2192.62,2009.17 c -1.78,-9.37 -1.78,-9.37 -1.78,-9.37 l -2.48,9.17 2.22,-2.21 z m 33.48,16.55 c 8.44,-2.95 8.44,-2.95 8.44,-2.95 l -8.63,-2.29 2.23,2.54 z m -11.48,-16.55 c -1.78,-9.37 -1.78,-9.37 -1.78,-9.37 l -2.48,9.17 2.22,-2.21 z" stroke="#000000" stroke-width="2.23952" /> <g id="text4101-5"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4640"><tspan x="2208.72" y="1996.03" id="tspan4638">H</tspan></text> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4644"><tspan x="2217.3899" y="1996.03" id="tspan4642">⁺</tspan></text> </g> <text id="text7967-0-3-9-8-3" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2462.1001" y="2029.55" id="tspan4647">PPi</tspan></text> <text id="text7967-0-3-2-6-5-8-4" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em"><tspan x="2516.1599" y="1996.16" id="tspan4650">Pi</tspan></text> <text id="text7967-0-3-9-14-7-5" fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="16px" font-weight="bold" letter-spacing="0em"><tspan x="2543.4399" y="2029.55" id="tspan4653">Pi</tspan></text> <g id="text7967-0-3-7-5-5-1"> <text fill="#000000" xml:space="preserve" style="white-space:pre" font-family="Arial" font-size="12px" letter-spacing="0em" id="text4660"><tspan x="2497.3799" y="2051.1599" id="tspan4656">H</tspan><tspan x="2510.28" y="2051.1599" id="tspan4658">O</tspan></text> <text fill="#000000" xml:space="preserve" 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letter-spacing="0em"><tspan x="2033.84" y="1209.63" id="tspan4673">0.01 dATP</tspan></text> <text id="text5543-5" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2031.09" y="1263.46" id="tspan4676">0.01 dGTP</tspan></text> <text id="text7967-0-3-6-2-0-0" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2042.22" y="1182.1899" id="tspan4679">0.05 UTP</tspan></text> <text id="text5590-1" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2032.47" y="1236.55" id="tspan4682">0.01 dCTP</tspan></text> <text id="text7967-0-3-6-2-7-4-6" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2048.21" y="1155.49" id="tspan4685">0.04CTP</tspan></text> <text 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Glu</tspan></text> <text id="text7967-0-3-6-2-0-0-7" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2448.8" y="1224.96" id="tspan4717">0.35 Asp</tspan></text> <text id="text5590-1-2" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2448.1001" y="1296.08" id="tspan4720">0.33 Gln</tspan></text> <text id="text7967-0-3-6-2-7-4-6-0" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2448.8" y="1201.4301" id="tspan4723">0.28 Asn</tspan></text> <text id="text7967-0-5-1-1-1" fill="#2b0000" xml:space="preserve" style="white-space:pre" font-family="Inter" font-size="16.1333px" letter-spacing="0em"><tspan x="2097.46" y="1489.5699" id="tspan4726">0.29 Ile</tspan></text> <text id="text7967-0-8-1" fill="#2b0000" xml:space="preserve" 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