# HG changeset patch # User francesco_lapi # Date 1732114782 0 # Node ID 824b1ecc29db10cb233514ae5f0a34658a99867b # Parent 14155e0bd8a5ed6efcc1da3c18e721fd48f946ed Uploaded diff -r 14155e0bd8a5 -r 824b1ecc29db COBRAxy/local/svg metabolic maps/ENGRO2_map.svg --- a/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 14:52:38 2024 +0000 +++ b/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 14:59:42 2024 +0000 @@ -24,15 +24,15 @@ inkscape:pagecheckerboard="0" inkscape:deskcolor="#d1d1d1" showgrid="false" - inkscape:zoom="1.3747927" - inkscape:cx="1345.6574" - inkscape:cy="916.86549" + inkscape:zoom="0.24303131" + inkscape:cx="999.87117" + inkscape:cy="1055.4196" inkscape:window-width="1920" inkscape:window-height="1009" inkscape:window-x="-8" inkscape:window-y="-8" inkscape:window-maximized="1" - inkscape:current-layer="svg5792" /> + inkscape:current-layer="ENGRO2_2" /> + stroke-width="2.84525" /> + id="Group 141" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> CySS CySS Leu Leu - + CySS + letter-spacing="0em" + x="10.300852" + y="1625.3644">CySS CySS + letter-spacing="0em" + x="137.93442" + y="1625.3644">CySS Ala + font-size="11.9656px" + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Ala Ala - - Ala + + Ser + font-size="11.9656px" + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Ser Ser + font-size="11.9656px" + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Ser CySS + letter-spacing="0em" + x="10.300852" + y="1498.7279">CySS CySS - + letter-spacing="0em" + x="137.93442" + y="1498.7279">CySS + CySS CySS Glu Glu @@ -452,34 +484,38 @@ id="text4049" fill="#2B0000" xml:space="preserve" - style="white-space:pre;fill:#000000" + style="white-space:pre;fill:#000000;stroke-width:0.997137" font-family="Arial" - font-size="16" + font-size="15.9542px" font-weight="bold" - letter-spacing="0em">Palm + style="fill:#000000;stroke-width:0.997137">Palm - - + + @@ -487,42 +523,46 @@ id="B_HDCAt" fill-rule="evenodd" clip-rule="evenodd" - d="m 56.090105,1324.6729 -9.7617,2.89 9.7292,3 -2.4203,-2.96 z" + d="m 66.161043,1336.2702 -9.723563,2.8848 9.69119,2.9945 -2.410844,-2.9546 z" fill="#2b0000" stroke="#000000" - stroke-width="2.32759" /> + stroke-width="2.32093" /> Chol + style="fill:#000000;stroke-width:0.997137">Chol - + @@ -530,97 +570,98 @@ id="B_r1050" fill-rule="evenodd" clip-rule="evenodd" - d="M58.1973 1351L48.4358 1353.89L58.165 1356.89L55.7447 1353.93L58.1973 1351Z" - fill="#2B0000" - stroke="black" + d="m 68.260006,1362.5495 -9.723364,2.8847 9.69119,2.9946 -2.410844,-2.9547 z" + fill="#2b0000" + stroke="#000000" stroke-width="2.32759" /> + id="Group 143" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Ala Asp Arg @@ -628,33 +669,33 @@ id="B_arg_L_t" fill-rule="evenodd" clip-rule="evenodd" - d="M2544.78 342.258L2547.19 339.294L2537.54 342.258L2547.19 345.221L2544.78 342.258Z" - fill="#2B0000" - stroke="black" + d="m 2544.78,342.258 2.41,-2.964 -9.65,2.964 9.65,2.963 z" + fill="#2b0000" + stroke="#000000" stroke-width="2.32327" /> Glu @@ -663,76 +704,76 @@ Ser Gly Asn @@ -741,77 +782,77 @@ Tyr Cys Pro Gln His Leu Ile Lys Met Phe Thr Trp Val - - + d="m 2542.1,628.975 c -9.67,-3.08 -9.67,-3.08 -9.67,-3.08 l 9.79,-2.671 -2.49,2.825 z" + stroke="#000000" + stroke-width="2.66667" /> + + + fill="#000000"> + id="Group 136" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> O ₂ @@ -1214,21 +1257,21 @@ id="B_EX_pi_e" fill-rule="evenodd" clip-rule="evenodd" - d="M120.431 1303.49L129.887 1300.53L120.431 1297.56L122.795 1300.53L120.431 1303.49Z" - stroke="black" + d="m 120.431,1303.49 9.456,-2.96 -9.456,-2.97 2.364,2.97 z" + stroke="#000000" stroke-width="2.85342" /> O @@ -1289,21 +1332,21 @@ id="F_PHLACHt" fill-rule="evenodd" clip-rule="evenodd" - d="M58.72 1205.25L49.0716 1208.21L58.72 1211.17L56.3078 1208.21L58.72 1205.25Z" - stroke="black" + d="m 58.72,1205.25 -9.6484,2.96 9.6484,2.96 -2.4122,-2.96 z" + stroke="#000000" stroke-width="2.32327" /> CO + id="Group 119" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> hcarn + id="Group 118" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 4abut + id="Group 120" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> anth + id="creatine" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Orn Arg HO ₂ NH Ci Gly GA Creatine SAM CreatineP ATP ADP Creatinine H Pi + id="Group 129" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> DHF NADP ⁺ H NADPH @@ -1917,87 +1965,87 @@ id="Group 128"> Folate NADP ⁺ H NADPH H ⁺ HO ₂ HO ₂ NADP ⁺ NADPH CO ₂ H ⁺ Formate THF Pi ADP ATP @@ -2338,92 +2386,92 @@ id="B_r0963" fill-rule="evenodd" clip-rule="evenodd" - d="M105.085 1962.98L114.821 1960L105.065 1957.09L107.512 1960.02L105.085 1962.98Z" - stroke="black" + d="m 105.085,1962.98 9.736,-2.98 -9.756,-2.91 2.447,2.93 z" + stroke="#000000" stroke-width="2.32759" /> 5,10mTHF 5,10meTHF NADH NAD ⁺ @@ -2431,54 +2479,54 @@ id="Group 124"> NADPH NADP ⁺ @@ -2486,348 +2534,355 @@ id="Group 122"> 2 H NH ₃ 5forthf NADPH 2 H NADP 5mTHF + id="path_aa_synthesis" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Amino acids synthesis / degradation - - + fill="#25ca25" /> + + Pentose Phosphate pathway - - + fill="#841bd7" /> + + Nucleotide synthesis - - + fill="#29bc90" /> + + Fatty acids / Cholesterol synthesis - - + fill="#cbe048" /> + + Urea cycle - - + fill="#c19c91" /> + + Ammonia detox - - + fill="#c19c91" /> + + - - + fill="#f018ce" /> + + Fatty acids β-oxidation - - + fill="#cbe048" /> + + Glutathione synthesis - - + fill="#aeaeae" /> + + Glycolysis / Gluconeogenesis - - + transform="matrix(0,1,1,0,98,392)" + fill="#da8f38" /> + + Ala AKG Glu - - + d="m 626,838 -2.5,-3.5 v 5 l 1.296,-1.868 z m -332.5,126.501 -7.5,5.5 9,-1 -3,-1 z" + stroke="#000000" + stroke-width="2.23952" /> + + GSSG GSH H ⁺ NADH NAD ⁺ HO ₂₂ GSH 2 HO ₂ GSH NADP ⁺ GSH H ⁺ NADPH GC Cys ATP Gly Pi ADP ATP Glu Pi ADP + id="space_mitochondria" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Mitochondrial space - - + fill="#0a0a0a" /> + + Glc Glc G6P F6P F1,6BP GA3P ATP NAD ⁺ NADH ATP ADP Pi HO ₂ HO ₂ Pi 1,3BPGA 3PG 2PG ADP ATP HO ₂ Pi Pyr ADP ATP H ⁺ NADH NAD ⁺ HO ₂ Putr - + letter-spacing="0em" + x="2070.3862" + y="642.18701">Putr + ametam spermidine - + letter-spacing="0em" + x="2121.7388" + y="559.42462">spermidine + ametam 5mta spermine - + letter-spacing="0em" + x="2126.7246" + y="493.61362">spermine + ⁺ ₂ CO 5mdr1p + letter-spacing="0em" + x="2361.0518" + y="594.3244">5mdr1p 5mdru1p - + letter-spacing="0em" + x="2356.0662" + y="534.49615">5mdru1p + ₂ HO dkmpp + letter-spacing="0em" + x="2360.0547" + y="470.67944">dkmpp met - + letter-spacing="0em" + x="2374.5132" + y="271.25201">met + 2 H ⁺ Glu + id="Group 167" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> HO ATP Pi PPi SAM - + letter-spacing="0em" + x="2212.9771" + y="268.26062">SAM + THF 5mTHF SAH - + letter-spacing="0em" + x="2109.2747" + y="268.26062">SAH + HO Adenosine - - + d="m 2023,252.5 c -1.76,-9.374 -1.73,-8.452 -1.73,-8.452 l -2.49,9.165 L 2021,251 Z m -20.44,9.103 c -9.81,2.62 -9.81,2.62 -9.81,2.62 l 9.65,3.131 -2.35,-2.939 z" + stroke="#000000" + stroke-width="2.23952" /> + + Pi PRPP PPi - - + d="m 2341,594.128 c 9.22,-2.82 9.23,-2.82 9.23,-2.82 l -9.16,-3.029 2.26,2.951 z m -44.25,-14.442 c -1.81,-9.364 -1.81,-9.364 -1.81,-9.364 l -2.44,9.178 2.21,-2.225 z" + stroke="#000000" + stroke-width="2.23952" /> + + H ADP AMP - - + d="m 2021.09,229.485 v -21.333 c 0,0 17.32,0 28.41,0 m 43.5,0 c 0,0 -26.51,0 -43.5,0 M 2021.09,188.5 c 0,19.652 13.41,19.652 13.41,19.652 m 29.5,0 c 27,0 27,-19.652 27,-19.652 m -41.5,19.652 c 14.5,0 14.5,-19.652 14.5,-19.652" + stroke="#000000" + stroke-width="2.23952" /> + + Hcys 5mTHF THF + id="Group 164" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> ₂ H ₂ O Pi ⁺ 2 H formate 2kmb - + letter-spacing="0em" + x="2368.0317" + y="352.02014">2kmb + Glu AKG Putr - + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Putr + + id="Group 148" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> spermine + id="Group 149" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> + id="Group 150" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> ₂ CO + id="Group 153" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> hcarn ATP AMP PPi 2 H ⁺ - - + d="m 1926.7,600.67 c 7.18,0.889 7.18,0.889 7.18,0.889 l -5.24,-4.996 0.58,2.789 z m 0,-14.933 c 7.18,0.889 7.18,0.889 7.18,0.889 l -5.24,-4.996 0.58,2.789 z m 0,-23.467 c 7.18,0.889 7.18,0.889 7.18,0.889 l -5.24,-4.996 0.58,2.789 z m -13.82,44.514 c 3.26,9.614 3.26,9.614 3.26,9.614 l 2.49,-9.839 -2.78,2.544 z" + stroke="#000000" + stroke-width="2.66667" /> + + ₂ HO His - - + d="m 1986.55,571.054 c 5.12,-5.115 5.12,-5.115 5.12,-5.115 l -7.17,1.061 2.56,1.255 z M 1949.89,535 c -9.89,2.283 -9.89,2.283 -9.89,2.283 l 9.54,3.459 -2.25,-3.018 z" + stroke="#000000" + stroke-width="2.66667" /> + + 4abutn ₂ HO NAD ⁺ - - + d="m 1960,523 c 2.33,-6.85 2.33,-6.85 2.33,-6.85 l 2.21,6.899 -2.25,-1.743 z m -10.34,11.204 c -9.66,-3.128 -9.66,-3.128 -9.66,-3.128 l 9.81,-2.623 -2.51,2.812 z" + stroke="#000000" + stroke-width="2.66667" /> + + ₂ H NADH Glu + id="g76852" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> ₂ H ₂ O ₂₂ ₃ NH - - + d="m 2071.52,586.431 -7.17,-1.027 5.15,5.096 -0.53,-2.8 z m 1.69,-25.755 -7.17,-1.027 5.15,5.096 -0.53,-2.8 z m 13.29,-9.176 -2.5,-5 -2,5 2,-1 z" + stroke="#000000" + stroke-width="2.66667" /> + + 2obut + id="Group 23" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 6Pgl NADP NADPH H ⁺ NADP NADPH CO ₂ H ⁺ HO ₂ AMP ATP R5P Xil5P Sed7P F6P Sed1,7BP Ery4P DHAP ATP ADP Ery4P GA3P F6P + id="Group 24" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> ADP ATP PRPP Gly 2 10fTHF 2 THF PPi 4 ADP Fum 2 Gln 2 Glu 4 ATP O CO Asp 2 ATP QH ₂ 2 ADP Gln Glu HCO ₃ Q H PPi CO UDP ATP ADP O dUMP ADP ATP dTMP 5,10meTHF DHF UTP CTP ADP Pi NH HO ₂ dCDP ATP ADP @@ -7158,50 +7279,50 @@ id="B_URIDK2r" fill-rule="evenodd" clip-rule="evenodd" - d="M1276.45 409.448C1274.62 415.149 1274.62 415.149 1274.62 415.149L1273.34 409.27L1274.83 410.806L1276.45 409.448ZM1269.45 403.296C1261.9 400.938 1261.9 400.938 1261.9 400.938L1269.52 398.814L1267.59 401.026L1269.45 403.296Z" - stroke="black" + d="m 1276.45,409.448 c -1.83,5.701 -1.83,5.701 -1.83,5.701 l -1.28,-5.879 1.49,1.536 z m -7,-6.152 c -7.55,-2.358 -7.55,-2.358 -7.55,-2.358 l 7.62,-2.124 -1.93,2.212 z" + stroke="#000000" stroke-width="1.95125" /> UMP GMP GDP 2 AMP ADP ADP O dADP ADP ATP dGTP ADP @@ -7465,25 +7586,25 @@ id="B_NDPK8" fill-rule="evenodd" clip-rule="evenodd" - d="M1330.68 144.434C1330.17 146.469 1329.67 148.503 1329.16 150.537C1328.34 148.584 1327.53 146.631 1326.71 144.677C1327.41 145.135 1328.11 145.593 1328.81 146.051C1329.44 145.512 1330.06 144.973 1330.68 144.434ZM1323.5 134.609C1321 133.77 1318.5 132.932 1316 132.094C1318.55 131.439 1321.11 130.784 1323.66 130.13C1323 130.853 1322.34 131.577 1321.68 132.3C1322.29 133.07 1322.89 133.839 1323.5 134.609Z" - fill="#2B0000" - stroke="black" + d="m 1330.68,144.434 c -0.51,2.035 -1.01,4.069 -1.52,6.103 -0.82,-1.953 -1.63,-3.906 -2.45,-5.86 0.7,0.458 1.4,0.916 2.1,1.374 0.63,-0.539 1.25,-1.078 1.87,-1.617 z m -7.18,-9.825 c -2.5,-0.839 -5,-1.677 -7.5,-2.515 2.55,-0.655 5.11,-1.31 7.66,-1.964 -0.66,0.723 -1.32,1.447 -1.98,2.17 0.61,0.77 1.21,1.539 1.82,2.309 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> dATP dCTP dTDP 4 Pi IMP 2 Pi @@ -7580,40 +7701,40 @@ id="B_TMDS" fill-rule="evenodd" clip-rule="evenodd" - d="M1371.55 408.698C1369.72 414.399 1369.72 414.399 1369.72 414.399L1368.44 408.52L1369.93 410.056L1371.55 408.698ZM1364.55 402.701C1357 400.344 1357 400.344 1357 400.344L1364.62 398.22L1362.69 400.432L1364.55 402.701Z" - fill="#2B0000" - stroke="black" + d="m 1371.55,408.698 c -1.83,5.701 -1.83,5.701 -1.83,5.701 l -1.28,-5.879 1.49,1.536 z m -7,-5.997 c -7.55,-2.357 -7.55,-2.357 -7.55,-2.357 l 7.62,-2.124 -1.93,2.212 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> ADP ATP @@ -7634,40 +7755,40 @@ id="B_DTMPK" fill-rule="evenodd" clip-rule="evenodd" - d="M1523.81 408.854C1521.98 414.554 1521.98 414.554 1521.98 414.554L1520.7 408.675L1522.19 410.212L1523.81 408.854ZM1516.81 402.701C1509.26 400.344 1509.26 400.344 1509.26 400.344L1516.88 398.22L1514.95 400.432L1516.81 402.701Z" - fill="#2B0000" - stroke="black" + d="m 1523.81,408.854 c -1.83,5.7 -1.83,5.7 -1.83,5.7 l -1.28,-5.879 1.49,1.537 z m -7,-6.153 c -7.55,-2.357 -7.55,-2.357 -7.55,-2.357 l 7.62,-2.124 -1.93,2.212 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> ADP ATP @@ -7688,39 +7809,39 @@ id="B_NDPK2" fill-rule="evenodd" clip-rule="evenodd" - d="M1275.62 344.538C1273.79 338.838 1273.79 338.838 1273.79 338.838L1272.51 344.717L1273.99 343.18L1275.62 344.538ZM1268.61 350.691C1261.07 353.049 1261.07 353.049 1261.07 353.049L1268.68 355.172L1266.75 352.961L1268.61 350.691Z" - stroke="black" + d="m 1275.62,344.538 c -1.83,-5.7 -1.83,-5.7 -1.83,-5.7 l -1.28,5.879 1.48,-1.537 z m -7.01,6.153 c -7.54,2.358 -7.54,2.358 -7.54,2.358 l 7.61,2.123 -1.93,-2.211 z" + stroke="#000000" stroke-width="1.95125" /> ADP ATP @@ -7741,29 +7862,29 @@ id="B_NDPK3" fill-rule="evenodd" clip-rule="evenodd" - d="M1501.9 344.558C1500.07 338.857 1500.07 338.857 1500.07 338.857L1498.79 344.737L1500.28 343.2L1501.9 344.558ZM1485.55 350.71C1478 353.068 1478 353.068 1478 353.068L1485.62 355.192L1483.69 352.98L1485.55 350.71Z" - fill="#2B0000" - stroke="black" + d="m 1501.9,344.558 c -1.83,-5.701 -1.83,-5.701 -1.83,-5.701 l -1.28,5.88 1.49,-1.537 z m -16.35,6.152 c -7.55,2.358 -7.55,2.358 -7.55,2.358 l 7.62,2.124 -1.93,-2.212 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> @@ -7771,61 +7892,61 @@ id="F_RNDR3" fill-rule="evenodd" clip-rule="evenodd" - d="M1592.6 355.47C1600.12 353.013 1600.12 353.013 1600.12 353.013L1592.48 350.99L1594.44 353.176L1592.6 355.47ZM1587.5 343.5L1585.5 340L1584.5 344L1586 343L1587.5 343.5Z" - fill="#2B0000" - stroke="black" + d="m 1592.6,355.47 c 7.52,-2.457 7.52,-2.457 7.52,-2.457 l -7.64,-2.023 1.96,2.186 z m -5.1,-11.97 -2,-3.5 -1,4 1.5,-1 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> GTP Asp GDP Pi NAD ⁺ O NH H AMP NADP ⁺ NH H ADP @@ -8141,37 +8262,37 @@ id="F_GK1" fill-rule="evenodd" clip-rule="evenodd" - d="M1538.3 243.915C1540.34 243.407 1542.37 242.899 1544.41 242.39C1542.45 241.574 1540.5 240.758 1538.55 239.941C1539.01 240.642 1539.46 241.343 1539.92 242.044C1539.38 242.668 1538.84 243.291 1538.3 243.915ZM1528.48 230.497C1527.64 227.998 1526.8 225.499 1525.96 223C1525.31 225.553 1524.65 228.107 1524 230.66C1524.72 230.001 1525.45 229.343 1526.17 228.684C1526.94 229.288 1527.71 229.893 1528.48 230.497Z" - fill="#2B0000" - stroke="black" + d="m 1538.3,243.915 c 2.04,-0.508 4.07,-1.016 6.11,-1.525 -1.96,-0.816 -3.91,-1.632 -5.86,-2.449 0.46,0.701 0.91,1.402 1.37,2.103 -0.54,0.624 -1.08,1.247 -1.62,1.871 z m -9.82,-13.418 c -0.84,-2.499 -1.68,-4.998 -2.52,-7.497 -0.65,2.553 -1.31,5.107 -1.96,7.66 0.72,-0.659 1.45,-1.317 2.17,-1.976 0.77,0.604 1.54,1.209 2.31,1.813 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> @@ -8179,61 +8300,61 @@ id="B_NDPK5" fill-rule="evenodd" clip-rule="evenodd" - d="M1567.52 150.716C1569.13 144 1569.13 144 1569.13 144L1571.37 150.524L1569.37 148.965L1567.52 150.716ZM1559.53 165.23C1552 162.814 1552 162.814 1552 162.814L1559.63 160.749L1557.69 162.946L1559.53 165.23Z" - fill="#2B0000" - stroke="black" + d="m 1567.52,150.716 c 1.61,-6.716 1.61,-6.716 1.61,-6.716 l 2.24,6.524 -2,-1.559 z m -7.99,14.514 c -7.53,-2.416 -7.53,-2.416 -7.53,-2.416 l 7.63,-2.065 -1.94,2.197 z" + fill="#2b0000" + stroke="#000000" stroke-width="1.95125" /> ADP ATP + id="Group 25" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> ATP HCO ⁻ ₃ H ⁺ ADP Pi CoA AcACP ACP CO ₂ ACP MalCoA CoA MalACP ACP AcCoA HO ₂ CoA AcAcCoA PalmCoA CoA AMP PPi ATP Palm @@ -8732,11 +8854,11 @@ id="Group 76"> AcAcACP 14 NADPH 14 NADP ⁺ 6 HO ₂ 6 CO ₂ 6 MalACP 7 ACP 14 H ⁺ HMGCoA 3 ATP CoA 2 NADPH 2 NADP ⁺ 3 ADP CO ₂ Pi 2 PPi fPP 2 ippPP ippPP 13 NADPH 2 10 O 13 NADP ⁺ 2 PPi formate 2 CO ₂ Chol fPP 15 HO ₂ 16 H ⁺ HMGCoA AcCoA CoA + id="Group 26" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 3 Ci 3 H ⁺ ⁻ ₃ 2 ADP Pi 2 ATP H H Ci CP Pi Orn - - - + d="m 1736.5,1145 -1.5,2.5 -0.5,-3.5 1.15,1 z m -7.76,-7.66 c -5.59,-1.93 -5.59,-1.93 -5.59,-1.93 l 5.74,-1.41 -1.49,1.61 z" + stroke="#000000" + stroke-width="2.23952" /> + + + Pi H Pi ATP ADP ATP ADP GTP GDP GTP HO HO O ₂ O ₂ @@ -10035,444 +10159,444 @@ id="F_O2tm" fill-rule="evenodd" clip-rule="evenodd" - d="M755.206 1269.9C764.427 1267.08 764.427 1267.08 764.427 1267.08L755.272 1264.05L757.536 1267L755.206 1269.9Z" - stroke="black" + d="m 755.206,1269.9 c 9.221,-2.82 9.221,-2.82 9.221,-2.82 l -9.155,-3.03 2.264,2.95 z" + stroke="#000000" stroke-width="2.61244" /> NADH NAD ⁺ 0.95 QH ₂ 4.75 H ⁺ 0.95 Q 3.8 H ⁺ FADH ₂ FAD QH ₂ Q 2 Cytc-ox 2 Cytc-red Q 2 H ⁺ QH ₂ 4 H ⁺ 4 Cytc-red 4 Cytc-ox 2 HO ₂ 8 H ⁺ O ₂ GSH GSH Pi Pi Gly Gly Mal AKG AKG ADP Pi ATP HO ₂ 4 H ⁺ 10-formylTHF HO ₂ 5,10meTHF NADPH NADP ⁺ H ⁺ THF HO ₂ CO CO NADH NADP NAD H H O ₂ O O ₂ ⁻ O ₂ 2 H O GSSG H NAD ⁺ H NADP ⁺ CO HCO ₃ H O Ser Ser 0.05 O ₂ 0.05 O ₂ ⁻ DHAP DHAP FAD FADH Gly3P Gly3P AcCoA Pyr NAD ⁺ NADP ⁺ NADH CO ₂ H ⁺ Pi H ATP HCO ₃ NAD ⁺ CoA 2 CO H ⁺ NADH NADPH H ⁺ CO ₂ @@ -12312,27 +12436,27 @@ id="B_H2Otm" fill-rule="evenodd" clip-rule="evenodd" - d="M1897.58 2052.92C1906.81 2055.74 1906.81 2055.74 1906.81 2055.74L1897.65 2058.77L1899.91 2055.82L1897.58 2052.92Z" - stroke="black" + d="m 1897.58,2052.92 c 9.23,2.82 9.23,2.82 9.23,2.82 l -9.16,3.03 2.26,-2.95 z" + stroke="#000000" stroke-width="2.61244" /> ATP Formate Formate H ⁺ H ⁺ H ⁺ H OAA Cit Isocit NADP ⁺ SuCoA Succ Fum Mal FADH NAD ⁺ O CoA O H GDP Pi CoA GTP NAD NADH CO H NADPH CO H NAD ⁺ NADH ⁺ H ⁺ CO ₂ @@ -13301,75 +13425,75 @@ id="B_ACONTm" fill-rule="evenodd" clip-rule="evenodd" - d="M1187.25 1346.98C1177 1349.33 1177 1349.33 1177 1349.33L1184.1 1342.63L1183.51 1345.94L1187.25 1346.98Z" - stroke="black" + d="m 1187.25,1346.98 c -10.25,2.35 -10.25,2.35 -10.25,2.35 l 7.1,-6.7 -0.59,3.31 z" + stroke="#000000" stroke-width="2.56963" /> H NH NAD ⁺ O H NH NADP ⁺ O NADP NADPH H ⁺ DHF NADP H ⁺ Folate 4 H ⁺ 4 H ⁺ H HO ₂ NAD ⁺ Gln Glu Gln NH ₃ O H ⁺ H ⁺ H ⁺ H ⁺ Folate + d="m 1384.57,932.624 6.19,20.898 -6.3,-5.514 -6.78,5.271 z m -2.25,14.098 2.22,-1.73 1.7,1.487 -1.81,-6.103 z m -106.98,45.696 -1.13,3.009 1.13,1.532 z m -2.38,-0.281 2.45,-6.545 2.25,0.408 v 18.04 l -9.1,-12.349 1.64,-1.622 z m -142.58,541.553 -4.01,5.22 4.12,5.14 -16.33,-5 z m -8.54,5.27 2.1,0.65 -0.53,-0.66 0.52,-0.68 z" + fill="#000000" /> + Mal Fum Pi Pi Fum @@ -14340,11 +14464,11 @@ id="Group 57"> GluSA Val, 3mob, propCoA @@ -14446,12 +14570,12 @@ id="Group 40"> Leu Leu Val Val H ⁺ H ⁺ Lys 3mob 3mob H ⁺ H ⁺ 4mop 4mop H ⁺ H ⁺ 2oxoadp 2oxoadp AKG AKG @@ -14871,56 +14995,56 @@ id="Group 39"> propCoA propCoA 5,10meTHF 5,10meTHF AKG Asp H H Glu AcAcCoA CoA 2 AcCoA NAD ⁺ H @@ -15270,43 +15394,43 @@ id="use1272-2-48"> HMGCoA Leu, 4mop Lys, 2oxoadp AcCoA O CoA H HO + id="Group 28" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Ci Orn ArgSuc Arg Fum HO ₂ @@ -15600,28 +15725,28 @@ id="Group 144"> Urea @@ -15631,22 +15756,22 @@ id="F_NH4t" fill-rule="evenodd" clip-rule="evenodd" - d="M1807.89 35.2407L1804.94 26.0001L1802 35.2407L1804.94 32.9306L1807.89 35.2407Z" - stroke="black" + d="m 1807.89,35.2407 -2.95,-9.2406 -2.94,9.2406 2.94,-2.3101 z" + stroke="#000000" stroke-width="3.3745" /> 3 + id="Group 30" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> PalmCarn PalmCarn Carn Carn PalmCoA Carn CoA 8 AcCoA 7 FAD 7 NAD 7 HO 7 FADH ₂ 7 NADH 7 H ⁺ - - + d="m 1450.52,1808.51 c 0.84,8.49 0.84,8.49 0.84,8.49 l 2.9,-7.97 -2.13,1.8 z m 51.1,0 c 0.84,8.49 0.84,8.49 0.84,8.49 l 2.9,-7.97 -2.13,1.8 z m 41.64,0 c 0.84,8.49 0.84,8.49 0.84,8.49 l 2.9,-7.97 -2.13,1.8 z M 1404.5,1795 l -8.5,3 8.5,3 -1.5,-3 z" + stroke="#000000" + stroke-width="2.23952" /> + + H CO ₂ HCO ₃ HO ₂ ADP Pi HO ₂ ATP H ⁺ PPi Pi Pi HO ₂ - - + d="m 2527.61,2026.74 c 9.67,-3.1 9.67,-3.1 9.67,-3.1 l -9.8,-2.65 2.5,2.82 z m -7.66,-16.32 c -1.78,-9.37 -1.78,-9.37 -1.78,-9.37 l -2.48,9.17 2.22,-2.22 z" + stroke="#000000" + stroke-width="2.23952" /> + + 0.01 dTTP 0.01 dATP 0.01 dGTP 0.05 UTP 0.01 dCTP 0.04CTP 0.27 Palm 20.65 H20 20.70 ATP 0.04 GTP 0.36 Arg 0.05 Cys 0.39 Glu 0.35 Asp 0.33 Gln 0.28 Asn 0.29 Ile 0.12 His 0.54 Gly 0.59Lys 0.41 Pro 0.26 Phe 0.15 Met 0.55 Leu 0.01 Trp 0.31Thr 0.16 Tyr 0.35Val 0.39 Ser 0.51 Ala Biomass 20.65 Pi 20.65ADP 20.65 H + d="m 2287.26,1076.98 -1.29,375.15 z" + fill="#000000" /> - - + d="m 2278.69,1068.05 -3.15,9.65 2.95,-2.35 2.8,2.51 z m 96.17,5.2 2.35,2.94 -2.52,2.81 9.81,-2.6 z m -180.3,20.63 -9.81,2.6 9.65,3.15 -2.35,-2.95 z m 182.25,8.74 2.35,2.95 -2.52,2.8 9.82,-2.6 z" + stroke="#000000" + stroke-width="2.66667" /> + + H ⁺ NADH Gly3P + id="Group 71" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> GTP CO ₂ GDP AKG Iso NADPH H ⁺ NADP ⁺ CO ₂ @@ -16973,60 +17103,60 @@ id="Group 70"> ATP CoA Pi ADP + d="m 1377.53,823.782 12.35,4.119 -4.72,1.887 v 4.904 z m -9.81,9.565 -3.97,5.249 4.15,5.11 -16.36,-4.902 z m -8.51,5.326 2.11,0.632 -0.53,-0.659 0.51,-0.677 z m 55.22,2.304 14.09,4.403 -15.74,6.119 4.33,-6.055 z m 5.14,4.046 0.32,0.533 -0.67,0.945 2.26,-0.881 z m -282.96,7.381 1.12,2.005 -4.05,3.234 5.78,6.493 -20.36,-5.48 z m -9.71,5.94 5.64,1.52 -2.22,-2.507 0.52,-0.423 z" + fill="#000000" /> Mal Glu Asp Fum NH ₃ NADPH H ⁺ CO ₂ NADP ⁺ @@ -17239,11 +17369,11 @@ id="Group 66"> H ⁺ NADH NAD ⁺ HO ₂ + id="Group 88" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 3PPyr NADH H ⁺ NAD ⁺ - - + d="m 280.899,728 c -9.783,2.705 -9.783,2.705 -9.783,2.705 l 9.682,3.047 -2.383,-2.919 z M 362,739.214 c 1.75,9.376 1.75,9.376 1.75,9.376 l 2.502,-9.162 -2.22,2.21 z" + stroke="#000000" + stroke-width="2.23952" /> + + CySS 2 GSH GSSG 2 Cys H ⁺ NADPH NADP NADH H ⁺ NAD HO ₂ NH ₃ Pyr - - + d="M 806.5,531.628 804,529 l 0.5,5 0.637,-2.372 z" + stroke="#000000" + stroke-width="2.66667" /> + + Asn AMP Glu PPi ATP Gln HO ₂ HO ₂ NH ₃ Asp + id="Group 116" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> P5C Pro H ⁺ NADH H ⁺ NADPH NAD ⁺ NADP ⁺ HO ₂ - - - + d="m 1246.53,591.078 c 8.42,3.024 8.42,3.024 8.42,3.024 l -8.65,2.209 2.25,-2.514 z m -18.42,-6.592 c 1.22,-9.46 1.22,-9.46 1.22,-9.46 l 3.01,9.007 -2.34,-2.082 z" + stroke="#000000" + stroke-width="2.23952" /> + + + NH ₃ HO ₂ NH ATP ADP Pi + id="Group 96" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> O ₂ Trp Lfmkynr + id="Group 95" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> formate H ⁺ HO ₂ Glu + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Glu urcan - + letter-spacing="0em" + x="1086.2119" + y="715.97516">urcan + NH ₃ His + id="Group 111" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> HO ₂ 4izp + letter-spacing="0em" + x="1165.9829" + y="715.97516">4izp forglu - - forglu + + H ⁺ 5forthf - + font-size="11.9656px" + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">5forthf + H HO ₂ THF + font-size="11.9656px" + letter-spacing="0em" + x="1311.5649" + y="701.01807">THF hgentis - + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">hgentis + hpp O ₂ CO ₂ - - + d="m 1015.92,596.889 c 2.21,-6.889 2.21,-6.889 2.21,-6.889 l 2.33,6.86 -2.29,-1.704 z m -4.16,13.42 C 1002,607.53 1002,607.53 1002,607.53 l 9.7,-2.973 -2.4,2.9 z" + stroke="#000000" + stroke-width="2.66667" /> + + 4mlacac O ₂ H ⁺ - - + d="m 968.5,566.133 c -7.86,2.175 -7.86,2.175 -7.86,2.175 l 6.86,2.325 -1.704,-2.284 z m 9.165,-5.371 C 974.886,551 974.886,551 974.886,551 l -2.973,9.705 2.9,-2.405 z" + stroke="#000000" + stroke-width="2.66667" /> + + 4fumacac - - + d="m 1030.72,544.752 c 9.76,-2.779 9.76,-2.779 9.76,-2.779 l -9.71,-2.973 2.41,2.9 z" + stroke="#000000" + stroke-width="2.66667" /> + + HO ₂ H ⁺ Fum AcAc - - + d="m 1182.1,545.565 c 9.76,-2.779 9.76,-2.779 9.76,-2.779 l -9.71,-2.973 2.41,2.9 z m -25.88,-11.716 C 1154,526.96 1154,526.96 1154,526.96 l -2.32,6.86 2.28,-1.704 z" + stroke="#000000" + stroke-width="2.66667" /> + + CoA ATP PPi AMP AcAcCoA - - + d="m 1334.67,545.87 c 9.76,-2.779 9.76,-2.779 9.76,-2.779 l -9.7,-2.973 2.4,2.9 z M 1313.5,535.5 c -2.22,-6.889 -1.72,-5.889 -1.72,-5.889 l -1.78,5.889 1.74,-0.733 z" + stroke="#000000" + stroke-width="2.66667" /> + + Lkynr anth H ⁺ HO ₂ + id="Group 93" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 2oxoadp Thr - + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">Thr + NH ₃ + id="use1272-8-6-2" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 2obut + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">2obut propCoA - + letter-spacing="0em" + x="10.300852" + y="13.990606" + transform="scale(0.99895309,1.001048)">propCoA + CoA NAD NADH CO ₂ - - + d="m 1349.9,768.503 c 9.76,-2.779 9.76,-2.779 9.76,-2.779 l -9.71,-2.973 2.41,2.9 z m -17.64,-13.42 c -2.22,-6.889 -2.22,-6.889 -2.22,-6.889 l -2.32,6.86 2.28,-1.704 z" + stroke="#000000" + stroke-width="2.66667" /> + + Tyr AKG Glu + id="Group 117" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 3mob Val Glu AKG + id="Group 102" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 4mop Leu Glu AKG + id="Group 90" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Cyst Cys NH ₃ 2-obut HO ₂ HO ₂ Hcys + id="Group 85" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> Gly THF HO ₂ 5,10meTHF - - + d="m 810.34,731.323 c 8.411,3.045 8.41,3.045 8.41,3.045 l -8.658,2.188 2.258,-2.509 z m -8.977,-8.609 c 1.751,-9.376 1.751,-9.376 1.751,-9.376 l 2.502,9.162 -2.22,-2.21 z" + stroke="#000000" + stroke-width="2.23952" /> + + HO ₂ Pi - - + d="m 666.323,735.233 c 8.41,-3.046 8.41,-3.046 8.41,-3.046 l -8.659,-2.187 2.258,2.509 z m -18.243,12.584 c 1.75,9.376 1.75,9.376 1.75,9.376 l 2.502,-9.162 -2.22,2.21 z" + stroke="#000000" + stroke-width="2.23952" /> + + NH ₃ + id="Group 87" + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> 3PSer Glu AKG + d="m 487.526,729.098 c -8.41,3.045 -8.41,3.045 -8.41,3.045 l 8.659,2.187 -2.258,-2.509 z m 12.354,19.578 c 1.751,9.376 1.751,9.376 1.751,9.376 l 2.502,-9.162 -2.22,2.21 z" + stroke="#000000" + stroke-width="2.23952" /> + + + AC + ATP + CoA + + - - AC - ATP - CoA - - -