# HG changeset patch # User francesco_lapi # Date 1732113211 0 # Node ID b15d097fd630bd953e89baab88f8c9db41fe5af3 # Parent 22043cbc201a248e01a2699d4743c3c37f08e306 Uploaded diff -r 22043cbc201a -r b15d097fd630 COBRAxy/local/svg metabolic maps/ENGRO2_map.svg --- a/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 14:19:21 2024 +0000 +++ b/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 14:33:31 2024 +0000 @@ -5,30 +5,17 @@ viewBox="0 0 2632 2412" fill="none" version="1.1" - id="svg1344" - sodipodi:docname="ENGRO2_map.svg" - inkscape:version="1.3 (0e150ed6c4, 2023-07-21)" + id="svg5792" + sodipodi:docname="ENGRO2_2.svg" + inkscape:version="1.2 (dc2aedaf03, 2022-05-15)" xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape" xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd" xmlns="http://www.w3.org/2000/svg" xmlns:svg="http://www.w3.org/2000/svg"> - - + id="defs5796" /> + inkscape:current-layer="svg5792" /> + width="2632" + height="2412" + fill="#F5F5F5" + id="rect2" /> + - AC - ATP - CoA - - - - + id="ENGRO2_2"> Legend: + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="32" + font-weight="bold" + letter-spacing="0em">Legend: = Up regulated + y="2350.32" + id="tspan7">= Up regulated = Down regulated + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="24" + font-weight="bold" + letter-spacing="0em">= Down regulated + d="M1040 2342H1152H1040Z" + fill="black" + id="path16" /> + id="path18" /> + stroke-dasharray="30 30" /> = Not classified + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="24" + font-weight="bold" + letter-spacing="0em">= Not classified = Not significant + y="2350.32" + id="tspan25">= Not significant = Fold change under threshold + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="24" + font-weight="bold" + letter-spacing="0em">= Fold change under threshold Thickness is proportional to fold change - - - - - - Thickness is proportional to fold change + + + + + + + + + CySS - CySS + CySS - Ala - Ala - - - - Ser - Ser - CySS - CySS - CySS + Leu + Leu + + + + - - - - + + + CySS + CySS + Ala + Ala + + + - CySS - + + + Ser + Ser + CySS + CySS + + + + + + + CySS - Leu - Leu - - - - CySS + id="tspan97">CySS CySS + id="tspan100">CySS Glu - + id="tspan103">Glu Glu - + id="tspan106">Glu + + Palm + + + + + + + Chol + - Chol - + - - - - - Palm - - - - + id="path126" /> + + Ala - + id="tspan131">Ala Asp - + y="434.136" + id="tspan134">Asp + + + + + d="M2613.24 373.182C2622.91 370.101 2622.91 370.101 2622.91 370.101L2613.12 367.431L2615.61 370.255L2613.24 373.182Z" + stroke="black" + stroke-width="2.66667" /> + + + + Arg - + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Arg + + + + - - Glu + y="551.864" + id="tspan157">Glu + + + + + + + + Ser - + id="tspan170">Ser Gly - - + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Gly + + + + Asn - + y="406.946" + id="tspan181">Asn + + + + + + + + Tyr - + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Tyr + + + + Cys - + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Cys + + + + Pro + id="tspan210">Pro + + + + Gln + y="522.688" + id="tspan218">Gln His + id="tspan223">His Leu + id="tspan228">Leu Ile + id="tspan233">Ile Lys + id="tspan238">Lys Met + id="tspan241">Met Phe + id="tspan246">Phe Thr + id="tspan251">Thr Trp + id="tspan256">Trp Val + id="tspan262">Val - - - - - - BH4 - - - - BH2 - - - - - - - - - O - ₂ - + d="M2542.1 628.975C2532.43 625.895 2532.43 625.895 2532.43 625.895L2542.22 623.224L2539.73 626.049L2542.1 628.975Z" + stroke="black" + stroke-width="2.66667" /> + fill="black"> - + id="rect285" /> + + mask="url(#path-133-outside-1_498_2)" + id="path290" /> + id="Group 140"> + + + + O + ₂ + + Pi + id="tspan307">Pi HHO - O + ₂ + id="tspan318">₂ @@ -1304,32 +1289,32 @@ id="F_PHLACHt" fill-rule="evenodd" clip-rule="evenodd" - d="m 58.72,1205.25 -9.6484,2.96 9.6484,2.96 -2.4122,-2.96 z" - stroke="#000000" + d="M58.72 1205.25L49.0716 1208.21L58.72 1211.17L56.3078 1208.21L58.72 1205.25Z" + stroke="black" stroke-width="2.32327" /> H + id="tspan326">H CO - CO + ₂ + id="tspan335">₂ @@ -1386,714 +1371,736 @@ id="Group 119"> hcarn + id="tspan347">hcarn 4abut + id="tspan353">4abut anth + id="tspan359">anth - + d="M379.344 1814C370 1812.09 370 1812.09 370 1812.09L379.203 1809.74L376.955 1811.92L379.344 1814ZM392.18 1800.63C395.372 1791 395.372 1791 395.372 1791L397.93 1800.82L395.134 1798.3L392.18 1800.63Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + Orn + id="tspan370">Orn Arg + id="tspan373">Arg HHO - O + ₂ + id="tspan382">₂ NH - NH + ₃ + id="tspan391">₃ Ci + id="tspan396">Ci Gly - - SAH - - Gly + GA + + + + - - Creatine - SAM - GA - - + id="path408" /> + + + Creatine + SAM + SAH + CreatineP + id="tspan425">CreatineP ATP + id="tspan428">ATP ADP + id="tspan431">ADP Creatinine + id="tspan436">Creatinine H - H + ⁺ + id="tspan443">⁺ Pi + id="tspan448">Pi - + d="M332.592 1860C323 1863.32 323 1863.32 323 1863.32L332.855 1865.75L330.293 1862.98L332.592 1860ZM344.658 1879.7C346.569 1889.04 346.569 1889.04 346.569 1889.04L348.914 1879.84L346.732 1882.09L344.658 1879.7Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + - - - - - + + + DHF + id="tspan464">DHF - + d="M315.351 1950.95C313.177 1945.95 313.177 1945.95 313.177 1945.95L310.937 1951.59L313.177 1949.4L315.351 1950.95ZM307.456 1956.59C299.019 1959.56 299.019 1959.56 299.019 1959.56L307.658 1961.83L305.423 1959.3L307.456 1956.59Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + NADP - ⁺ + id="tspan474">NADP + ⁺ H - H + ⁺ + id="tspan487">⁺ NADPH - - + id="tspan492">NADPH + + Folate + transform="translate(121 1953)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + font-weight="bold" + letter-spacing="0em">Folate - + d="M177.351 1950.95C175.177 1945.95 175.177 1945.95 175.177 1945.95L172.937 1951.59L175.177 1949.4L177.351 1950.95ZM169.456 1956.59C161.019 1959.56 161.019 1959.56 161.019 1959.56L169.658 1961.83L167.423 1959.3L169.456 1956.59Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + NADP - ⁺ + id="tspan506">NADP + ⁺ H - H + ⁺ + id="tspan519">⁺ NADPH + id="tspan524">NADPH 10formylTHF + id="tspan528">10formylTHF H - ⁺ + id="tspan531">H + ⁺ HHO - O + ₂ + y="2148.16" + id="tspan546">₂ HHO - ₂ + id="tspan557">O + ₂ NADP - ⁺ + id="tspan566">NADP + ⁺ NADPH + transform="translate(354 2022)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH CO - ₂ + transform="translate(378 1975)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text580">CO + ₂ H - ⁺ + id="tspan587">H + ⁺ Formate + id="tspan596">Formate THF + id="tspan599">THF Pi + id="tspan602">Pi ADP + id="tspan605">ADP - + d="M429.5 2074.5C438.86 2072.67 438.86 2072.67 438.86 2072.67L432 2069.5L429.5 2074.5ZM417.209 2074.5C420 2084.26 420 2084.26 420 2084.26L422.961 2074.55L420.064 2076.96L417.209 2074.5Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + ATP - + transform="translate(440 2025)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP + d="M406.394 1982.75L401.503 1980.74L406.142 1978.5L403.951 1980.74L406.394 1982.75ZM410.642 1977.46C413.612 1969.02 413.612 1969.02 413.612 1969.02L415.876 1977.66L413.348 1975.42L410.642 1977.46Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + 5,10mTHF + transform="translate(386 2162)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + font-weight="bold" + letter-spacing="0em">5,10mTHF 5,10meTHF + transform="translate(243 2162)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + font-weight="bold" + letter-spacing="0em">5,10meTHF NADH + transform="translate(352 2131)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH NAD - ⁺ + y="2142.16" + id="tspan639">NAD + ⁺ NADPH + transform="translate(351 2195)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH NADP - NADP + ⁺ + y="2206.16" + id="tspan659">⁺ 2 H + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2 H NH - NH + ₃ + y="2200.16" + id="tspan674">₃ 5forthf + y="2173.16" + id="tspan679">5forthf NADPH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH 2 - 2 + H + y="2156.16" + id="tspan691">H NADP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADP 5mTHF + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + font-weight="bold" + letter-spacing="0em">5mTHF Amino acids synthesis / degradation + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="20" + font-weight="bold" + letter-spacing="0em">Amino acids synthesis / degradation - - + fill="#25CA25" /> + + Pentose Phosphate pathway + y="164.434" + id="tspan714">Pentose Phosphate pathway - - + fill="#841BD7" /> + + Nucleotide synthesis + y="99.4336" + id="tspan721">Nucleotide synthesis + fill="#29BC90" /> Fatty acids / Cholesterol synthesis + y="711.434" + id="tspan728">Fatty acids / Cholesterol synthesis + fill="#CBE048" /> Urea cycle + y="491.434" + id="tspan735">Urea cycle + fill="#C19C91" /> Ammonia detox + y="1103.43" + id="tspan742">Ammonia detox + fill="#C19C91" /> Biomass + id="tspan749">Biomass + fill="#F018CE" /> Fatty acids β-oxidation + y="1743.43" + id="tspan756">Fatty acids β-oxidation + fill="#CBE048" /> Glutathione synthesis + y="2085.43" + id="tspan763">Glutathione synthesis + fill="#AEAEAE" /> Glycolysis / Gluconeogenesis + y="18.4336" + id="tspan770">Glycolysis / Gluconeogenesis + transform="matrix(0 1 1 0 98 392)" + fill="#DA8F38" /> Ala + id="tspan775">Ala AKG + font-size="12" + letter-spacing="0em">AKG Glu + font-size="12" + letter-spacing="0em">Glu GSSG + id="tspan788">GSSG GSH + id="tspan791">GSH H - H + ⁺ + y="2154.16" + id="tspan799">⁺ NADH + y="2154.16" + id="tspan804">NADH NAD - ⁺ + y="2160.16" + id="tspan807">NAD + ⁺ HHO - O + ₂₂ + y="2117.16" + id="tspan822">₂₂ GSH + y="2117.16" + id="tspan829">GSH 2 H2 HO - ₂ + y="2112.16" + id="tspan835">O + ₂ GSH + y="2160.16" + id="tspan844">GSH NADP - ⁺ + y="2198.16" + id="tspan850">NADP + ⁺ GSH + y="2198.16" + id="tspan859">GSH H - H + ⁺ + y="2193.16" + id="tspan867">⁺ NADPH + y="2193.16" + id="tspan872">NADPH GC + id="tspan882">GC Cys + id="tspan885">Cys ATP + y="2123.16" + id="tspan888">ATP Gly + y="2123.16" + id="tspan893">Gly Pi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Pi ADP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ADP ATP + y="2123.16" + id="tspan903">ATP Glu + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Glu Pi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Pi ADP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ADP Mitochondrial space + y="1027.43" + id="tspan920">Mitochondrial space + fill="#0A0A0A" /> Glc + id="tspan925">Glc Glc + id="tspan928">Glc G6P + id="tspan931">G6P F6P + id="tspan934">F6P F1,6BP + id="tspan937">F1,6BP GA3P + id="tspan940">GA3P ATP + id="tspan943">ATP ADP + id="tspan946">ADP NAD - ⁺ + y="558.16" + id="tspan949">NAD + ⁺ NADH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH ATP + id="tspan968">ATP ADP + id="tspan971">ADP Pi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Pi HHO - ₂ + id="tspan988">O + ₂ Pi + id="tspan997">Pi HHO - ₂ + id="tspan1002">O + ₂ Pi + id="tspan1011">Pi 1,3BPGA + id="tspan1021">1,3BPGA 3PG + id="tspan1024">3PG 2PG + id="tspan1027">2PG ADP + font-size="13.3333" + letter-spacing="0em">ADP ATP + font-size="13.3333" + letter-spacing="0em">ATP 2,3BPG + id="tspan1041">2,3BPG HHO - O + ₂ + y="757.16" + id="tspan1050">₂ Pi + y="767.16" + id="tspan1055">Pi PEP + id="tspan1066">PEP Pyr + id="tspan1070">Pyr ADP + y="919.16" + id="tspan1074">ADP ATP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP Lact + id="tspan1082">Lact H - ⁺ + y="961.16" + id="tspan1085">H + ⁺ NADH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH NAD - ⁺ + y="909.16" + id="tspan1097">NAD + ⁺ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text1118">HO + ₂ Putr + id="tspan1128">Putr ametam + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ametam 5mta + id="tspan1136">5mta spermidine + id="tspan1140">spermidine ametam + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ametam 5mta + y="520.41" + id="tspan1148">5mta spermine + id="tspan1152">spermine ⁺ - ⁺ + H + id="tspan1159">H ₂ - CO + transform="translate(2221.5 632)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text1166">₂ + CO SAM + id="tspan1175">SAM 5mdr1p + id="tspan1179">5mdr1p 5mdru1p + id="tspan1184">5mdru1p ₂ - H₂ + HO + y="505.122" + id="tspan1195">O dkmpp + id="tspan1201">dkmpp met + id="tspan1204">met Gln + id="tspan1207">Gln 2 H - 2 H + ⁺ + id="tspan1214">⁺ Glu + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Glu HHO - O + ₂ + id="tspan1231">₂ ATP + id="tspan1236">ATP Pi + id="tspan1239">Pi PPi + id="tspan1242">PPi SAM + id="tspan1248">SAM THF + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">THF 5mTHF + id="tspan1254">5mTHF SAH + id="tspan1260">SAH HHO - O + ₂ + id="tspan1269">₂ Adenosine + id="tspan1274">Adenosine Pi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Pi adenine + id="tspan1284">adenine PRPP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">PRPP PPi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">PPi AMP + id="tspan1295">AMP ATP + id="tspan1301">ATP H - H + ⁺ + id="tspan1308">⁺ ADP + id="tspan1313">ADP AMP + id="tspan1316">AMP Hcys + id="tspan1322">Hcys 5mTHF + id="tspan1327">5mTHF THF + id="tspan1330">THF - + - + + id="path1339" /> ₂ - ₂ + HHO + id="tspan1348">O ₂ - ₂ + O + id="tspan1357">O Pi + id="tspan1362">Pi ⁺ - ⁺ + 2 H + id="tspan1369">2 H formate + id="tspan1374">formate 2kmb + id="tspan1378">2kmb Glu + y="325.911" + id="tspan1383">Glu AKG + y="305.889" + id="tspan1386">AKG + + Putr + + + + + + + + spermine + + + + + spermidine + @@ -5145,3240 +5252,3215 @@ id="F_ORNDC" fill-rule="evenodd" clip-rule="evenodd" - d="m 2052.5,643 8.5,-3.5 -7,-1.5 1,1.5 z m -115.5,14.5 6.48,2.266 1.52,-2.266 1.48,5.766 z" - stroke="#000000" + d="M2052.5 643L2061 639.5L2054 638L2055 639.5L2052.5 643ZM1937 657.5L1943.48 659.766L1945 657.5L1946.48 663.266L1937 657.5Z" + stroke="black" stroke-width="1.95125" /> ₂ - CO + transform="translate(1939 664)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text1413">₂ + CO hcarn + id="tspan1421">hcarn ATP + y="572.16" + id="tspan1424">ATP AMP + y="591.16" + id="tspan1427">AMP PPi + y="607.16" + id="tspan1430">PPi His + id="tspan1433">His 2 H - 2 H + ⁺ + y="568.16" + id="tspan1440">⁺ ₂ - ₂ + HHO + y="609.16" + id="tspan1455">O His + id="tspan1460">His 4abutn + id="tspan1465">4abutn ₂ - ₂ + HHO + y="518.16" + id="tspan1475">O NAD - ⁺ + y="521.16" + id="tspan1480">NAD + ⁺ 4abut + id="tspan1491">4abut ₂ - ₂ + CO + id="tspan1498">CO H - H + ⁺ + id="tspan1507">⁺ NADH + id="tspan1512">NADH Glu + id="tspan1517">Glu ₂ - H₂ + HO + id="tspan1528">O ₂ - O + transform="translate(2100 572)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text1535">₂ + O ₂₂ - ₂₂ + HHO + id="tspan1550">O ₃ - NH + transform="translate(2042 553)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text1557">₃ + NH - - - Putr - - - - - - - - spermine - - - - - spermidine - - - - - - 2obut - + d="M2071.52 586.431L2064.35 585.404L2069.5 590.5L2068.97 587.7L2071.52 586.431ZM2073.21 560.676L2066.04 559.649L2071.19 564.745L2070.66 561.945L2073.21 560.676ZM2086.5 551.5L2084 546.5L2082 551.5L2084 550.5L2086.5 551.5Z" + stroke="black" + stroke-width="2.66667" /> + + + + + 2obut 6Pgl + id="tspan1572">6Pgl NADP - NADP + ⁺ + id="tspan1579">⁺ NADPH + id="tspan1584">NADPH H - H + ⁺ + id="tspan1591">⁺ 6PDG + id="tspan1596">6PDG NADP - NADP + ⁺ + id="tspan1603">⁺ NADPH + id="tspan1608">NADPH CO - CO + ₂ + id="tspan1615">₂ H - H + ⁺ + id="tspan1624">⁺ Ru5P + id="tspan1629">Ru5P HHO - O + ₂ + id="tspan1639">₂ AMP + id="tspan1650">AMP ATP + id="tspan1653">ATP R5P + id="tspan1658">R5P Xil5P + id="tspan1665">Xil5P Sed7P + id="tspan1672">Sed7P GA3P + id="tspan1675">GA3P F6P + id="tspan1681">F6P Sed1,7BP + id="tspan1684">Sed1,7BP Ery4P + id="tspan1687">Ery4P DHAP + id="tspan1690">DHAP ATP + transform="translate(624 302)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP ADP + id="tspan1696">ADP Ery4P + id="tspan1705">Ery4P GA3P + id="tspan1711">GA3P F6P + id="tspan1714">F6P Xil5P + id="tspan1717">Xil5P ADP + id="tspan1722">ADP ATP + transform="translate(1594 416.333) rotate(-0.829907)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP dTTP + id="tspan1728">dTTP - + + id="path1735" /> PRPP + y="288.312" + id="tspan1739">PRPP Gly + id="tspan1742">Gly 2 10fTHF + id="tspan1745">2 10fTHF 2 THF + id="tspan1748">2 THF PPi + id="tspan1751">PPi 4 ADP + id="tspan1754">4 ADP Fum + id="tspan1757">Fum 2 Gln + id="tspan1760">2 Gln 2 Glu + id="tspan1763">2 Glu 4 ATP + id="tspan1766">4 ATP Asp + id="tspan1769">Asp HHO - O + ₂ + id="tspan1778">₂ CO - CO + ₂ + id="tspan1787">₂ Asp + id="tspan1792">Asp 2 ATP + id="tspan1795">2 ATP QH - QH + ₂ + id="tspan1802">₂ 2 ADP + id="tspan1807">2 ADP Gln + id="tspan1810">Gln Glu + id="tspan1813">Glu HCO - HCO + ₃ - ₃ + ⁻ + id="tspan1824">⁻ Q + id="tspan1829">Q H - H + ⁺ + id="tspan1836">⁺ PPi + y="331.278" + id="tspan1841">PPi CO - CO + ₂ + id="tspan1848">₂ UDP + id="tspan1853">UDP ATP + id="tspan1856">ATP ADP + id="tspan1859">ADP dUDP + id="tspan1862">dUDP HHO - O + ₂ + id="tspan1871">₂ dUMP + id="tspan1878">dUMP ADP + id="tspan1881">ADP ATP + transform="translate(1285 416.333) rotate(-0.829907)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP dTMP + id="tspan1887">dTMP 5,10meTHF + transform="translate(1345 416.466) rotate(-0.416974)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">5,10meTHF DHF + id="tspan1893">DHF UTP + id="tspan1896">UTP CTP + id="tspan1899">CTP ADP + id="tspan1902">ADP Pi + id="tspan1905">Pi ATP + id="tspan1908">ATP NH - NH + ₃ + id="tspan1915">₃ CDP + id="tspan1920">CDP HHO - ₂ + id="tspan1925">O + ₂ dCDP + id="tspan1934">dCDP ATP + transform="translate(1653.06 320) rotate(0.250513)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP ADP - + id="tspan1940">ADP + d="M1684.65 340.48C1683.2 333.192 1683.2 333.192 1683.2 333.192L1681.34 340.352L1683.05 338.61L1684.65 340.48ZM1690.44 355.88C1697.92 353.336 1697.92 353.336 1697.92 353.336L1690.26 351.401L1692.24 353.564L1690.44 355.88Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + - + d="M1671.3 341.229C1669.86 333.94 1669.86 333.94 1669.86 333.94L1667.99 341.1L1669.7 339.358L1671.3 341.229ZM1660.38 351.45C1652.86 353.894 1652.86 353.894 1652.86 353.894L1660.5 355.93L1658.54 353.741L1660.38 351.45Z" + fill="#2B0000" + stroke="black" + stroke-width="2.23952" /> + + + + - + + + + UMP + y="358.868" + id="tspan1963">UMP GMP + id="tspan1966">GMP GDP + id="tspan1969">GDP dGDP + id="tspan1972">dGDP 2 - 2 + HHO + id="tspan1981">O AMP + id="tspan1986">AMP ADP + id="tspan1989">ADP ADP + id="tspan1992">ADP ATP + id="tspan1995">ATP HHO - O + ₂ + id="tspan2004">₂ dADP + id="tspan2009">dADP ADP + id="tspan2020">ADP ATP + id="tspan2023">ATP dGTP + id="tspan2026">dGTP ADP + id="tspan2029">ADP ATP + id="tspan2032">ATP - + + id="path2037" /> dATP + id="tspan2042">dATP dCTP + id="tspan2045">dCTP dTDP + id="tspan2048">dTDP 4 Pi + id="tspan2051">4 Pi IMP + y="286.998" + id="tspan2056">IMP 2 Pi + y="331.157" + id="tspan2059">2 Pi - + + id="path2065" /> ADP + id="tspan2070">ADP ATP + transform="translate(1503 416.333) rotate(-0.829907)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP - + + id="path2078" /> ADP + id="tspan2083">ADP ATP + transform="translate(1257 325.952) rotate(-0.829907)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP + + id="path2091" /> ADP + id="tspan2096">ADP ATP + transform="translate(1512.42 325.631) rotate(-0.829907)" + fill="#2B0000" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP + + id="path2104" /> + + id="path2111" /> GTP + id="tspan2115">GTP Asp + id="tspan2118">Asp GDP + id="tspan2121">GDP Pi + id="tspan2124">Pi Fum + id="tspan2127">Fum NAD - NAD + ⁺ + id="tspan2134">⁺ HHO - O + ₂ + id="tspan2145">₂ ATP + id="tspan2150">ATP NH - NH + ₃ + id="tspan2157">₃ NADH + id="tspan2162">NADH H - H + ⁺ + id="tspan2169">⁺ AMP + id="tspan2174">AMP PPi + id="tspan2177">PPi NADP - NADP + ⁺ + id="tspan2185">⁺ NH - NH + ₃ + id="tspan2194">₃ H - H + ⁺ + id="tspan2203">⁺ NADPH + id="tspan2208">NADPH ADP + id="tspan2216">ADP ATP + id="tspan2219">ATP + + id="path2224" /> + + id="path2232" /> + + id="path2239" /> ADP + id="tspan2242">ADP ATP + id="tspan2245">ATP GTP + id="tspan2248">GTP + + id="path2255" /> - - - + + + + id="path2264" /> - - - + + + + id="path2273" /> ATP + y="881.16" + id="tspan2277">ATP HCO - HCO + ⁻ - ⁻ + ₃ + y="881.16" + id="tspan2288">₃ H - H + ⁺ + y="881.16" + id="tspan2297">⁺ ADP + y="845.16" + id="tspan2302">ADP Pi + y="845.16" + id="tspan2305">Pi CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA AcACP + id="tspan2313">AcACP ACP + y="832.16" + id="tspan2316">ACP CO - CO + ₂ + y="797.16" + id="tspan2326">₂ ACP + y="797.16" + id="tspan2332">ACP MalCoA + y="865.321" + id="tspan2337">MalCoA CoA + y="844.16" + id="tspan2341">CoA MalACP + y="867.725" + id="tspan2344">MalACP ACP + y="881.16" + id="tspan2347">ACP AcCoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AcCoA HHO - O + ₂ + y="955.16" + id="tspan2361">₂ CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA AcAcCoA + y="940.648" + id="tspan2369">AcAcCoA PalmCoA + id="tspan2375">PalmCoA CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA AMP + y="761.16" + id="tspan2381">AMP PPi + id="tspan2384">PPi ATP + y="788.16" + id="tspan2387">ATP Palm + id="tspan2392">Palm AcAcACP + id="tspan2396">AcAcACP 14 NADPH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">14 NADPH 14 NADP - ⁺ + y="794.16" + id="tspan2402">14 NADP + ⁺ 6 H6 HO - ₂ + y="794.16" + id="tspan2413">O + ₂ 6 CO - 6 CO + ₂ + y="794.16" + id="tspan2426">₂ 6 MalACP + y="833.16" + id="tspan2431">6 MalACP 7 ACP + y="794.16" + id="tspan2434">7 ACP 14 H - ⁺ + y="833.16" + id="tspan2438">14 H + ⁺ HMGCoA + id="tspan2449">HMGCoA 3 ATP + y="954.16" + id="tspan2452">3 ATP CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA 2 NADPH + y="954.16" + id="tspan2458">2 NADPH 2 NADP - 2 NADP + ⁺ + y="919.16" + id="tspan2465">⁺ 3 ADP + y="919.16" + id="tspan2470">3 ADP CO - CO + ₂ + y="919.16" + id="tspan2477">₂ Pi + y="919.16" + id="tspan2482">Pi 2 PPi + y="919.16" + id="tspan2488">2 PPi fPP + id="tspan2491">fPP 2 ippPP + y="955.16" + id="tspan2494">2 ippPP ippPP + id="tspan2497">ippPP 13 NADPH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">13 NADPH 2 - 10 O + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text2508">2 + 10 O 13 NADP - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text2517">13 NADP + ⁺ 2 PPi + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2 PPi formate + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">formate 2 CO - 2 CO + ₂ + y="917.16" + id="tspan2534">₂ Chol + id="tspan2539">Chol fPP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">fPP 15 HO - ₂ + y="917.16" + id="tspan2545">15 HO + ₂ 16 H - ⁺ + y="957.16" + id="tspan2559">16 H + ⁺ AcCoA + id="tspan2569">AcCoA HMGCoA + id="tspan2572">HMGCoA AcCoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AcCoA CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA @@ -9278,354 +9360,354 @@ 3 - 3 + NH + id="tspan2593">NH Ci + id="tspan2602">Ci 3 - 3 + NH + id="tspan2609">NH H - ⁺ + id="tspan2614">H + ⁺ ⁻ - ₃ - ⁻ + ₃ + HCO + id="tspan2631">HCO 2 ADP + id="tspan2636">2 ADP Pi + id="tspan2639">Pi 2 ATP + transform="translate(1586 1145)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2 ATP Orn + id="tspan2648">Orn H - H + ⁺ + id="tspan2655">⁺ Orn + id="tspan2661">Orn H - H + ⁺ + id="tspan2668">⁺ Ci + id="tspan2674">Ci CP + id="tspan2677">CP Pi + id="tspan2680">Pi Orn + transform="translate(1723 1148)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Orn @@ -9635,1396 +9717,1396 @@ id="B_r0801" fill-rule="evenodd" clip-rule="evenodd" - d="m 1926.42,1954.04 c 9.22,-2.82 9.22,-2.82 9.22,-2.82 l -9.15,-3.03 2.26,2.95 z m -76.65,-18.8 c -2.44,-7.82 -2.44,-7.82 -2.44,-7.82 l -3.37,7.49 3.02,-1.75 z" - stroke="#000000" + d="M1926.42 1954.04C1935.64 1951.22 1935.64 1951.22 1935.64 1951.22L1926.49 1948.19L1928.75 1951.14L1926.42 1954.04ZM1849.77 1935.24C1847.33 1927.42 1847.33 1927.42 1847.33 1927.42L1843.96 1934.91L1846.98 1933.16L1849.77 1935.24Z" + stroke="black" stroke-width="2.37958" /> Pi + id="tspan2693">Pi H - H + ⁺ + id="tspan2700">⁺ Pi + id="tspan2705">Pi ATP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">ATP ADP + id="tspan2713">ADP ATP + id="tspan2716">ATP ADP + id="tspan2719">ADP GTP + id="tspan2724">GTP GDP + id="tspan2727">GDP GTP + id="tspan2730">GTP GDP + id="tspan2733">GDP HHO - O + ₂ + id="tspan2745">₂ HHO - O + ₂ + id="tspan2756">₂ O - O + ₂ + id="tspan2765">₂ O - O + ₂ + id="tspan2774">₂ NADH + id="tspan2782">NADH NAD - NAD + ⁺ + y="2131.16" + id="tspan2789">⁺ 0.95 QH - 0.95 QH + ₂ + y="2131.16" + id="tspan2798">₂ 4.75 H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text2805">4.75 H + ⁺ 0.95 Q + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">0.95 Q 3.8 H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text2817">3.8 H + ⁺ FADH - FADH + ₂ + y="2080.16" + id="tspan2828">₂ FAD + y="2080.16" + id="tspan2833">FAD QH - QH + ₂ + y="2080.16" + id="tspan2840">₂ Q + y="2080.16" + id="tspan2845">Q 2 Cytc-ox + y="2131.16" + id="tspan2849">2 Cytc-ox 2 Cytc-red + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2 Cytc-red Q + y="2131.16" + id="tspan2855">Q 2 H - 2 H + ⁺ + y="2131.16" + id="tspan2862">⁺ QH - QH + ₂ + y="2131.16" + id="tspan2871">₂ 4 H - 4 H + ⁺ + y="2217.16" + id="tspan2881">⁺ 4 Cytc-red + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">4 Cytc-red 4 Cytc-ox + y="2131.16" + id="tspan2889">4 Cytc-ox 2 H2 HO - ₂ + y="2131.16" + id="tspan2894">O + ₂ 8 H - 8 H + ⁺ + y="2131.16" + id="tspan2907">⁺ O - O + ₂ + y="2131.16" + id="tspan2916">₂ GSH + id="tspan2923">GSH GSH + id="tspan2926">GSH Pi + id="tspan2932">Pi Pi + id="tspan2935">Pi Gly + id="tspan2940">Gly Gly + id="tspan2943">Gly Mal + id="tspan2947">Mal AKG + id="tspan2950">AKG AKG + id="tspan2953">AKG ADP + y="2131.16" + id="tspan2959">ADP Pi + y="2131.16" + id="tspan2962">Pi ATP + y="2131.16" + id="tspan2965">ATP HHO - O + ₂ + y="2131.16" + id="tspan2974">₂ 4 H - 4 H + ⁺ + y="2131.16" + id="tspan2983">⁺ 10-formylTHF + id="tspan2988">10-formylTHF 5,10mTHF + id="tspan2991">5,10mTHF HHO - ₂ + id="tspan2996">O + ₂ 5,10meTHF + id="tspan3006">5,10meTHF NADPH + transform="translate(999.199 1960) rotate(0.813633)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH NADP - ⁺ + id="tspan3015">NADP + ⁺ H - ⁺ + id="tspan3024">H + ⁺ THF + id="tspan3033">THF HHO - O + ₂ + id="tspan3042">₂ CO - CO + ₂ + id="tspan3051">₂ CO - CO + ₂ + id="tspan3060">₂ NADH + id="tspan3068">NADH NADPH + id="tspan3071">NADPH NADP - NADP + ⁺ + id="tspan3078">⁺ NAD - NAD + ⁺ + id="tspan3087">⁺ H - H + ⁺ + id="tspan3097">⁺ H - H + ⁺ + id="tspan3107">⁺ HHO - O + ₂₂₂ + id="tspan3121">₂ 2 H2 HO - O + ₂ + id="tspan3132">₂ 2 GSH + id="tspan3137">2 GSH O - O + ₂ - ₂ + ⁻ + id="tspan3148">⁻ O - O + ₂ - ₂ + ⁻ + id="tspan3161">⁻ 2 H - 2 H + ⁺ + id="tspan3170">⁺ O - O + ₂ + id="tspan3179">₂ GSSG + id="tspan3186">GSSG NADH + id="tspan3192">NADH H + id="tspan3195">H ⁺ + id="tspan3199">⁺ NAD + id="tspan3204">NAD ⁺ + id="tspan3208">⁺ NADPH + id="tspan3213">NADPH H + id="tspan3216">H ⁺ + id="tspan3220">⁺ NADP + id="tspan3225">NADP ⁺ + id="tspan3229">⁺ CO - CO + ₂ + id="tspan3243">₂ HCO - HCO + ₃ - ₃ + ⁻ + id="tspan3256">⁻ H - H + ⁺ + id="tspan3266">⁺ HHO - O + ₂ + id="tspan3277">₂ ADP + id="tspan3284">ADP Ser + id="tspan3289">Ser Ser + id="tspan3292">Ser 0.05 O - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text3299">0.05 O + ₂ 0.05 O - 0.05 O + ₂ - ⁻ + y="2131.16" + id="tspan3311">₂ + ⁻ DHAP + id="tspan3322">DHAP DHAP + id="tspan3325">DHAP FAD + id="tspan3328">FAD FADH - FADH + ₂ + id="tspan3336">₂ Gly3P + id="tspan3342">Gly3P Gly3P + id="tspan3345">Gly3P AcCoA + id="tspan3351">AcCoA Pyr + id="tspan3354">Pyr NAD - NAD + ⁺ + id="tspan3362">⁺ NADP - NADP + ⁺ + id="tspan3371">⁺ NADH + id="tspan3376">NADH CO - CO + ₂ + id="tspan3383">₂ H - H + ⁺ + id="tspan3392">⁺ Pi + id="tspan3401">Pi ADP + id="tspan3404">ADP H - H + ⁺ + id="tspan3411">⁺ ATP + id="tspan3416">ATP HCO - HCO + ₃ - ₃ + ⁻ + id="tspan3427">⁻ NAD - NAD + ⁺ + id="tspan3436">⁺ CoA + id="tspan3441">CoA 2 - 2 + CO + id="tspan3448">CO H - H + ⁺ + id="tspan3457">⁺ NADH + id="tspan3462">NADH + id="path3466" /> + id="path3468" /> + id="path3470" /> + id="path3472" /> NADPH + id="tspan3476">NADPH H - H + ⁺ + id="tspan3483">⁺ CO - CO + ₂ + id="tspan3492">₂ Pi + id="tspan3501">Pi - + - + + id="path3508" /> ATP + transform="translate(1013 1854.01)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP Formate + id="tspan3516">Formate Formate + id="tspan3521">Formate Formate + id="tspan3526">Formate H - H + ⁺ + id="tspan3541">⁺ H - H + ⁺ + id="tspan3550">⁺ H - H + ⁺ + id="tspan3559">⁺ Mal + id="tspan3564">Mal H - H + ⁺ + id="tspan3571">⁺ OAA + id="tspan3576">OAA Cit + id="tspan3579">Cit Isocit + id="tspan3582">Isocit AKG + id="tspan3585">AKG NADP - NADP + ⁺ + id="tspan3592">⁺ SuCoA + id="tspan3597">SuCoA Succ + id="tspan3600">Succ Fum + id="tspan3603">Fum Mal + id="tspan3606">Mal FAD + id="tspan3610">FAD FADH - FADH + ₂ + id="tspan3617">₂ NAD - NAD + ⁺ + id="tspan3626">⁺ HHO - O + ₂ + id="tspan3638">₂ CoA + id="tspan3643">CoA HHO - O + ₂ + id="tspan3655">₂ - + NADH + id="tspan3666">NADH H - H + ⁺ + id="tspan3674">⁺ GDP + id="tspan3681">GDP Pi + id="tspan3684">Pi CoA + id="tspan3687">CoA GTP + y="1691.81" + id="tspan3690">GTP CoA + id="tspan3696">CoA NAD + id="tspan3699">NAD ⁺ + id="tspan3703">⁺ NADH + id="tspan3710">NADH CO + id="tspan3713">CO ₂ + id="tspan3717">₂ H + id="tspan3722">H ⁺ + id="tspan3726">⁺ NADPH - NADPH + ⁺ + id="tspan3736">⁺ CO - CO + ₂ + id="tspan3745">₂ H - H + ⁺ + id="tspan3754">⁺ NAD - NAD + ⁺ + id="tspan3767">⁺ NADH - ⁺ + transform="translate(1358 1421.93) rotate(-1.36526)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text3774">NADH + ⁺ H - ⁺ + id="tspan3781">H + ⁺ CO - ₂ + transform="translate(1353 1403.55) rotate(-1.36526)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text3792">CO + ₂ + id="path3805" /> + id="path3807" /> + id="path3809" /> NADH + id="tspan3815">NADH H - H + ⁺ + id="tspan3822">⁺ NH - NH + ₃ + id="tspan3831">₃ NAD - NAD + ⁺ + id="tspan3840">⁺ HHO - O + ₂ + id="tspan3851">₂ NADPH + id="tspan3856">NADPH H - H + ⁺ + id="tspan3863">⁺ NH - NH + ₃ + id="tspan3872">₃ NADP - NADP + ⁺ + id="tspan3881">⁺ HHO - O + ₂ + id="tspan3892">₂ NADP - NADP + ⁺ + id="tspan3908">⁺ NADPH + y="1808.43" + id="tspan3913">NADPH H - H + ⁺ + id="tspan3920">⁺ DHF + id="tspan3925">DHF NADP - NADP + ⁺ + id="tspan3935">⁺ NADPH + id="tspan3940">NADPH H - H + ⁺ + id="tspan3947">⁺ Folate + id="tspan3952">Folate 4 H - 4 H + ⁺ + y="2217.16" + id="tspan3962">⁺ 4 H - 4 H + ⁺ + y="2217.16" + id="tspan3971">⁺ NADH + id="tspan3976">NADH H - H + ⁺ + id="tspan3983">⁺ HHO - ₂ + id="tspan3990">O + ₂ NAD - ⁺ + id="tspan3999">NAD + ⁺ Gln + id="tspan4011">Gln Glu + id="tspan4014">Glu Gln + id="tspan4019">Gln NH - ₃ + transform="translate(1755 1398)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4026">NH + ₃ Glu + id="tspan4033">Glu HHO - O + ₂ + id="tspan4042">₂ H - ⁺ + id="tspan4049">H + ⁺ H - ⁺ + id="tspan4058">H + ⁺ H - ⁺ + id="tspan4067">H + ⁺ H - ⁺ + id="tspan4076">H + ⁺ Folate + id="tspan4086">Folate + id="F_HMR_4964" + fill-rule="evenodd" + clip-rule="evenodd" + d="M1384.57 932.624L1390.76 953.522L1384.46 948.008L1377.68 953.279L1384.57 932.624ZM1382.32 946.722L1384.54 944.992L1386.24 946.479L1384.43 940.376L1382.32 946.722ZM1275.34 992.418L1274.21 995.427L1275.34 996.959V992.418ZM1272.96 992.137L1275.41 985.592L1277.66 986V1004.04L1268.56 991.691L1270.2 990.069L1272.96 992.137ZM1130.38 1533.69L1126.37 1538.91L1130.49 1544.05L1114.16 1539.05L1130.38 1533.69ZM1121.84 1538.96L1123.94 1539.61L1123.41 1538.95L1123.93 1538.27L1121.84 1538.96Z" + fill="black" /> + + - + + H + id="tspan4096">H Mal + id="tspan4101">Mal Fum + id="tspan4104">Fum Pi + id="tspan4110">Pi Pi + id="tspan4113">Pi Fum + id="tspan4116">Fum GluSA + id="tspan4120">GluSA GluSA + id="tspan4126">GluSA + d="M1493.04 1585.41L1508.97 1601.35L1493.04 1585.41Z" + fill="#AACCEE" + id="path4134" /> + id="path4136" /> + d="M1493.04 1601.35L1508.97 1585.41L1493.04 1601.35Z" + fill="#AACCEE" + id="path4139" /> + id="path4141" /> Val, 3mob, propCoA + id="tspan4145">Val, 3mob, propCoA Leu + id="tspan4149">Leu Leu + id="tspan4152">Leu Val + id="tspan4159">Val Val + id="tspan4162">Val H - ⁺ + id="tspan4171">H + ⁺ H - ⁺ + id="tspan4180">H + ⁺ Lys + id="tspan4189">Lys Lys + id="tspan4192">Lys 3mob + id="tspan4196">3mob 3mob + id="tspan4199">3mob H - ⁺ + id="tspan4202">H + ⁺ H - ⁺ + id="tspan4211">H + ⁺ 4mop + id="tspan4223">4mop 4mop + id="tspan4226">4mop H - ⁺ + id="tspan4229">H + ⁺ H - ⁺ + id="tspan4238">H + ⁺ 2oxoadp + id="tspan4250">2oxoadp 2oxoadp + id="tspan4253">2oxoadp AKG + transform="translate(683.92 1429) rotate(1.03014)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AKG AKG + transform="translate(733.901 1429.48) rotate(1.03014)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AKG propCoA + id="tspan4264">propCoA propCoA + id="tspan4267">propCoA 5,10meTHF + id="tspan4274">5,10meTHF 5,10meTHF + id="tspan4277">5,10meTHF AKG + id="tspan4284">AKG Glu + id="tspan4287">Glu + id="path4290" /> + id="path4292" /> Asp + id="tspan4297">Asp Glu + id="tspan4300">Glu H - H + ⁺ + id="tspan4307">⁺ H - H + ⁺ + id="tspan4316">⁺ Glu + id="tspan4321">Glu AcAcCoA + id="tspan4327">AcAcCoA CoA + id="tspan4332">CoA 2 AcCoA + id="tspan4335">2 AcCoA NADH + id="tspan4341">NADH NAD - NAD + ⁺ + id="tspan4348">⁺ H - H + ⁺ + id="tspan4357">⁺ + d="M1639.41 2029.41L1655.35 2045.35L1639.41 2029.41Z" + fill="#AACCEE" + id="path4363" /> + id="path4365" /> + d="M1639.41 2045.35L1655.35 2029.41L1639.41 2045.35Z" + fill="#AACCEE" + id="path4368" /> + id="path4370" /> + d="M1553.41 1906.41L1569.35 1922.35L1553.41 1906.41Z" + fill="#AACCEE" + id="path4375" /> + id="path4377" /> + d="M1553.41 1922.35L1569.35 1906.41L1553.41 1922.35Z" + fill="#AACCEE" + id="path4380" /> + id="path4382" /> HMGCoA + id="tspan4386">HMGCoA Leu, 4mop + id="tspan4389">Leu, 4mop Lys, 2oxoadp + id="tspan4392">Lys, 2oxoadp AcCoA + id="tspan4396">AcCoA HHO - O + ₂ + id="tspan4405">₂ CoA + id="tspan4410">CoA H - H + ⁺ + id="tspan4417">⁺ HHO - O + ₂ + id="tspan4429">₂ @@ -15380,159 +15469,159 @@ id="Group 156"> Ci + id="tspan4444">Ci Orn + id="tspan4447">Orn ArgSuc + id="tspan4450">ArgSuc Arg + id="tspan4453">Arg Fum + transform="translate(1593.23 513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Fum HHO - ₂ + id="tspan4462">O + ₂ Urea + id="tspan4471">Urea @@ -15542,40 +15631,40 @@ id="F_NH4t" fill-rule="evenodd" clip-rule="evenodd" - d="m 1807.89,35.2407 -2.95,-9.2406 -2.94,9.2406 2.94,-2.3101 z" - stroke="#000000" + d="M1807.89 35.2407L1804.94 26.0001L1802 35.2407L1804.94 32.9306L1807.89 35.2407Z" + stroke="black" stroke-width="3.3745" /> 3 - 3 + NH + id="tspan4484">NH @@ -15583,286 +15672,286 @@ id="Group 30"> PalmCarn + y="1802.32" + id="tspan4491">PalmCarn PalmCarn + y="1802.32" + id="tspan4494">PalmCarn Carn + transform="translate(1900 1819.01)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Carn Carn + transform="translate(1817 1819.01)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Carn PalmCoA + id="tspan4506">PalmCoA Carn + transform="translate(1654 1760.01)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Carn CoA + transform="translate(1684 1759)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA 8 AcCoA + id="tspan4518">8 AcCoA 7 FAD + transform="translate(1548.06 1772) rotate(0.250513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">7 FAD 7 NAD - 7 NAD + ⁺ + id="tspan4528">⁺ 7 CoA + id="tspan4533">7 CoA 7 HO - 7 HO + ₂ + id="tspan4542">₂ 7 FADH - ₂ + transform="translate(1524.06 1818.51) rotate(0.250513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4550">7 FADH + ₂ 7 NADH + transform="translate(1431.06 1818.51) rotate(0.250513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">7 NADH 7 H - ⁺ + transform="translate(1492.06 1818.51) rotate(0.250513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4562">7 H + ⁺ H - H + ⁺ + id="tspan4575">⁺ CO - CO + ₂ + id="tspan4584">₂ HCO - HCO + ₃ - ₃ + ⁻ + id="tspan4598">⁻ HHO - O + ₂ + y="2056.16" + id="tspan4610">₂ ADP + id="tspan4616">ADP Pi + id="tspan4619">Pi HHO - O + ₂ + id="tspan4628">₂ ATP + id="tspan4633">ATP H - H + ⁺ + id="tspan4642">⁺ PPi + id="tspan4647">PPi Pi + id="tspan4650">Pi Pi + id="tspan4653">Pi HHO - O + ₂ + y="2051.16" + id="tspan4662">₂ 0.01 dTTP + id="tspan4670">0.01 dTTP 0.01 dATP + id="tspan4673">0.01 dATP 0.01 dGTP + id="tspan4676">0.01 dGTP 0.05 UTP + y="1182.19" + id="tspan4679">0.05 UTP 0.01 dCTP + id="tspan4682">0.01 dCTP 0.04CTP + id="tspan4685">0.04CTP 0.27 Palm + y="1331.82" + id="tspan4688">0.27 Palm 0.20 Chol + id="tspan4691">0.20 Chol 0.28 G6P + id="tspan4694">0.28 G6P 20.65 H20 + id="tspan4698">20.65 H20 20.70 ATP + y="1443.19" + id="tspan4701">20.70 ATP 0.04 GTP + id="tspan4705">0.04 GTP 0.36 Arg + id="tspan4708">0.36 Arg 0.05 Cys + id="tspan4711">0.05 Cys 0.39 Glu + id="tspan4714">0.39 Glu 0.35 Asp + id="tspan4717">0.35 Asp 0.33 Gln + id="tspan4720">0.33 Gln 0.28 Asn + y="1201.43" + id="tspan4723">0.28 Asn 0.29 Ile + y="1489.57" + id="tspan4726">0.29 Ile 0.12 His + id="tspan4729">0.12 His 0.54 Gly + id="tspan4732">0.54 Gly 0.59Lys + id="tspan4735">0.59Lys 0.41 Pro + id="tspan4738">0.41 Pro 0.26 Phe + id="tspan4741">0.26 Phe 0.15 Met + id="tspan4744">0.15 Met 0.55 Leu + id="tspan4747">0.55 Leu 0.01 Trp + id="tspan4750">0.01 Trp 0.31Thr + id="tspan4753">0.31Thr 0.16 Tyr + y="1389.68" + id="tspan4756">0.16 Tyr 0.35Val + id="tspan4759">0.35Val 0.39 Ser + id="tspan4762">0.39 Ser 0.51 Ala + id="tspan4765">0.51 Ala Biomass + id="tspan4768">Biomass 20.65 Pi + y="1080.31" + id="tspan4771">20.65 Pi 20.65ADP + id="tspan4774">20.65ADP 20.65 H - + id="tspan4777">20.65 H + + + + + H - ⁺ + id="tspan4788">H + ⁺ NADH - - NAD - ⁺ - + transform="translate(348.061 472) rotate(0.250513)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH Gly3P + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Gly3P @@ -16682,1415 +16754,1386 @@ id="Group 69"> GTP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">GTP CO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4811">CO + ₂ GDP + y="854.16" + id="tspan4818">GDP + id="path4821" /> + id="path4823" /> + id="path4825" /> AKG + id="tspan4834">AKG Iso + id="tspan4837">Iso NADPH + y="897.16" + id="tspan4840">NADPH H - H + ⁺ + y="904.16" + id="tspan4847">⁺ NADP - ⁺ + y="946.16" + id="tspan4852">NADP + ⁺ CO - CO + ₂ + y="958.16" + id="tspan4868">₂ ATP + y="900.16" + id="tspan4874">ATP CoA + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA Pi - PPi - AMP + y="826.16" + id="tspan4880">Pi ADP + y="843.16" + id="tspan4883">ADP + d="M1381.29 910.507C1381.29 910.507 1381.4 878.503 1381.29 845.5C1381.29 845.5 1392.32 845.5 1397 845.5M1421.5 845.5C1421.5 845.5 1406.96 845.501 1397 845.5M1128 857.5H1381.12C1381.16 870.5 1403.59 871.356 1403.59 871.356M1381.24 887.524C1383.94 897.381 1403.22 896.187 1403.22 896.187M1381.1 851.499C1381.04 833.999 1363.2 839.101 1363.2 839.101M1397 845.5C1396.5 830.5 1385 830.5 1385 830.5" + stroke="black" + stroke-width="2.37609" /> Cit - Cit + + d="M1377.53 823.782L1389.88 827.901L1385.16 829.788V834.692L1377.53 823.782ZM1367.72 833.347L1363.75 838.596L1367.9 843.706L1351.54 838.804L1367.72 833.347ZM1359.21 838.673L1361.32 839.305L1360.79 838.646L1361.3 837.969L1359.21 838.673ZM1414.43 840.977L1428.52 845.38L1412.78 851.499L1417.11 845.444L1414.43 840.977ZM1419.57 845.023L1419.89 845.556L1419.22 846.501L1421.48 845.62L1419.57 845.023ZM1136.61 852.404L1137.73 854.409L1133.68 857.643L1139.46 864.136L1119.1 858.656L1136.61 852.404ZM1126.9 858.344L1132.54 859.864L1130.32 857.357L1130.84 856.934L1126.9 858.344Z" + fill="black" /> Mal + y="864.318" + id="tspan4892">Mal Glu + y="909.16" + id="tspan4895">Glu Asp + id="tspan4901">Asp Fum + id="tspan4904">Fum NH - NH + ₃ + y="982.16" + id="tspan4913">₃ NADPH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4925">H + ⁺ CO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4934">CO + ₂ NADP - NADP + ⁺ + y="956.16" + id="tspan4945">⁺ OAA + id="tspan4951">OAA H - H + ⁺ + y="895.16" + id="tspan4958">⁺ NADH + y="892.16" + id="tspan4963">NADH NAD - NAD + ⁺ + y="895.16" + id="tspan4970">⁺ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text4986">HO + ₂ 3PPyr + id="tspan4994">3PPyr NADH + font-size="12" + letter-spacing="0em">NADH H - H + ⁺ + font-size="12" + letter-spacing="0em" + id="text5006">⁺ NAD - NAD + ⁺ + font-size="12" + letter-spacing="0em" + id="text5015">⁺ CySS + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">CySS 2 GSH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2 GSH GSSG + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">GSSG 2 Cys + id="tspan5032">2 Cys H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5040">H + ⁺ NADPH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADPH NADP + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADP NADH + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5058">H + ⁺ NAD + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NAD HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5074">HO + ₂ NH - ₃ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5083">NH + ₃ Pyr + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Pyr Asn + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Asn AMP + transform="translate(552.156 555) rotate(0.638475)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AMP Glu + transform="translate(560.156 531) rotate(0.638475)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Glu PPi + id="tspan5109">PPi ATP + transform="translate(563.156 640) rotate(0.638475)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">ATP Gln + transform="translate(567.156 661) rotate(0.638475)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Gln HHO - ₂ + id="tspan5120">O + ₂ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5134">HO + ₂ NH - ₃ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5143">NH + ₃ Asp + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="16" + font-weight="bold" + letter-spacing="0em">Asp P5C + id="tspan5157">P5C Pro + id="tspan5160">Pro H - H + ⁺ + y="635.16" + id="tspan5171">⁺ NADH + y="614.16" + id="tspan5176">NADH H - H + ⁺ + y="635.16" + id="tspan5183">⁺ NADPH + y="614.16" + id="tspan5188">NADPH NAD - ⁺ + y="653.16" + id="tspan5191">NAD + ⁺ NADP - ⁺ + y="653.16" + id="tspan5200">NADP + ⁺ GluSA + id="tspan5209">GluSA HHO - O + ₂ + y="569.16" + id="tspan5218">₂ @@ -18098,634 +18141,996 @@ id="Group 99"> NH - NH + ₃ + y="657.16" + id="tspan5233">₃ Gln + id="tspan5238">Gln HHO - O + ₂ + y="620.16" + id="tspan5247">₂ NH - NH + ₃ + id="tspan5256">₃ ATP + id="tspan5262">ATP ADP + y="627.322" + id="tspan5267">ADP Pi + y="611.424" + id="tspan5270">Pi O - O + ₂ + y="741.16" + id="tspan5278">₂ Trp + id="tspan5283">Trp Lfmkynr + id="tspan5288">Lfmkynr formate + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">formate H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5297">H + ⁺ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5311">HO + ₂ Glu + id="tspan5319">Glu urcan + id="tspan5322">urcan NH - ₃ + transform="translate(1045 687)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5328">NH + ₃ His + id="tspan5336">His HHO - ₂ + id="tspan5343">O + ₂ 4izp + id="tspan5354">4izp forglu + id="tspan5357">forglu H - H + ⁺ + id="text5366">⁺ 5forthf + y="688.16" + id="tspan5369">5forthf H + transform="translate(1224 685)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">H HHO - O + ₂ + y="703.16" + id="tspan5382">₂ THF + id="tspan5391">THF + hgentis + + hpp + + + O + ₂ + + + CO + ₂ + + + + + 4mlacac + + + O + ₂ + + + H + ⁺ + + + + + + 4fumacac + + + + + + HO + ₂ + + + H + ⁺ + + Fum + AcAc + + + + + CoA + ATP + PPi + AMP + AcAcCoA + + Lkynr + id="tspan5498">Lkynr anth + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">anth H - ⁺ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5508">H + ⁺ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5519">HO + ₂ + d="M927.414 685.415L943.348 701.348L927.414 685.415Z" + fill="#AACCEE" + id="path5528" /> + id="path5530" /> + d="M927.414 701.348L943.348 685.415L927.414 701.348Z" + fill="#AACCEE" + id="path5533" /> + id="path5535" /> 2oxoadp + id="tspan5539">2oxoadp Thr + id="tspan5545">Thr NH - NH + ₃ - - + y="746.16" + id="tspan5552">₃ + + - + + id="path5563" /> - + + id="path5568" /> 2obut + id="tspan5572">2obut propCoA + x="1363.44" + y="767.649" + id="tspan5575">propCoA CoA + transform="translate(1290 740)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">CoA NAD + transform="translate(1260 740)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NAD NADH + transform="translate(1346.25 734) rotate(1.03014)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">NADH CO - ₂ + transform="translate(1318.25 734) rotate(1.03014)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5592">CO + ₂ - - - + + + hgentis - - hpp - - - O - ₂ - - - CO - ₂ - - - - - 4mlacac - - - O - ₂ - - - H - ⁺ - - - - - - 4fumacac - - - - - - HO - ₂ - - - H - ⁺ - - Fum - AcAc - - - - - CoA - ATP - PPi - AMP - AcAcCoA - - - - Tyr - - - - AKG - Glu - - - Phe - - - - - - - BH4 - BH2 - - HO - ₂ - - - O - ₂ - - + id="tspan5601">Tyr + + + + AKG + Glu 3mob + id="tspan5614">3mob Val + id="tspan5618">Val Glu + transform="translate(1099 632)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Glu AKG + y="643.16" + id="tspan5625">AKG + d="M1184.13 654.415L1200.07 670.348L1184.13 654.415Z" + fill="#AACCEE" + id="path5630" /> + id="path5632" /> + d="M1184.13 670.348L1200.07 654.415L1184.13 670.348Z" + fill="#AACCEE" + id="path5635" /> + id="path5637" /> @@ -19612,99 +19532,99 @@ id="Group 102"> 4mop + id="tspan5642">4mop Leu + id="tspan5646">Leu Glu + transform="translate(910 632)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Glu AKG + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">AKG + d="M988.414 652.415L1004.35 668.348L988.414 652.415Z" + fill="#AACCEE" + id="path5658" /> + id="path5660" /> + d="M988.414 668.348L1004.35 652.415L988.414 668.348Z" + fill="#AACCEE" + id="path5663" /> + id="path5665" /> @@ -19712,231 +19632,231 @@ id="Group 90"> Cyst + id="tspan5670">Cyst Cys + id="tspan5673">Cys NH - ₃ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5678">NH + ₃ 2-obut + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">2-obut HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5692">HO + ₂ HO - ₂ + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em" + id="text5708">HO + ₂ Hcys + transform="translate(646 710)" + fill="black" + xml:space="preserve" + style="white-space: pre" + font-family="Arial" + font-size="12" + letter-spacing="0em">Hcys Gly + id="tspan5719">Gly THF + font-size="12" + letter-spacing="0em">THF HHO - O + ₂ + font-size="12" + letter-spacing="0em" + id="text5733">₂ 5,10meTHF + font-size="12" + letter-spacing="0em">5,10meTHF HO - HO + ₂ + y="762.864" + id="tspan5748">₂ Pi + font-size="12" + letter-spacing="0em">Pi Ser + id="tspan5759">Ser NH - NH + ₃ + y="813.864" + id="tspan5766">₃ - + + id="path5774" /> 3PSer + id="tspan5778">3PSer Glu + font-size="12" + letter-spacing="0em">Glu AKG + font-size="12" + letter-spacing="0em">AKG