# HG changeset patch # User francesco_lapi # Date 1732116425 0 # Node ID c5b17211bb022c262959210368800acd848aadff # Parent ac38b4765bc1d9452a6001e8ec345fe06545400b Uploaded diff -r ac38b4765bc1 -r c5b17211bb02 COBRAxy/local/svg metabolic maps/ENGRO2_map.svg --- a/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 15:00:08 2024 +0000 +++ b/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Wed Nov 20 15:27:05 2024 +0000 @@ -24,14 +24,14 @@ inkscape:pagecheckerboard="0" inkscape:deskcolor="#d1d1d1" showgrid="false" - inkscape:zoom="0.24303131" - inkscape:cx="999.87117" - inkscape:cy="1055.4196" - inkscape:window-width="1920" - inkscape:window-height="1009" - inkscape:window-x="-8" - inkscape:window-y="-8" - inkscape:window-maximized="1" + inkscape:zoom="3.888501" + inkscape:cx="118.04035" + inkscape:cy="1614.2467" + inkscape:window-width="1388" + inkscape:window-height="1032" + inkscape:window-x="601" + inkscape:window-y="12" + inkscape:window-maximized="0" inkscape:current-layer="ENGRO2_2" /> + stroke-width="2.85342" /> - + id="Group 141"> + - + + id="path38" + inkscape:label="R_t_Lcystin_leu__L" /> CySS CySS Leu Leu - - + + + id="path57" + inkscape:label="R_t_Lcystin_ala__L" /> CySS + letter-spacing="0em">CySS CySS + letter-spacing="0em">CySS Ala + font-size="12" + letter-spacing="0em">Ala Ala + font-size="12" + letter-spacing="0em">Ala - - + + + id="path75" + inkscape:label="R_t_Lcystin_ser__L" /> Ser + font-size="12" + letter-spacing="0em">Ser Ser + font-size="12" + letter-spacing="0em">Ser CySS + letter-spacing="0em">CySS CySS - - + letter-spacing="0em">CySS + + - + + id="path93" + inkscape:label="R_t_Lcystin_glu__L" /> CySS CySS Glu Glu @@ -484,184 +464,180 @@ id="text4049" fill="#2B0000" xml:space="preserve" - style="white-space:pre;fill:#000000;stroke-width:0.997137" + style="white-space:pre;fill:#000000" font-family="Arial" - font-size="15.9542px" + font-size="16" font-weight="bold" - letter-spacing="0em" - x="10.300852" - y="13.990606" - transform="scale(0.99895309,1.001048)">Palm + style="fill:#000000">Palm - - - + + + + id="path116" + inkscape:label="R_HDCAt" /> + stroke-width="2.32759" /> Chol + style="fill:#000000">Chol - - + + + id="path126" + inkscape:label="R_r1050" /> + id="Group 143"> Ala Asp Arg @@ -669,33 +645,33 @@ id="B_arg_L_t" fill-rule="evenodd" clip-rule="evenodd" - d="m 2544.78,342.258 2.41,-2.964 -9.65,2.964 9.65,2.963 z" - fill="#2b0000" - stroke="#000000" + d="M2544.78 342.258L2547.19 339.294L2537.54 342.258L2547.19 345.221L2544.78 342.258Z" + fill="#2B0000" + stroke="black" stroke-width="2.32327" /> Glu @@ -704,76 +680,76 @@ Ser Gly Asn @@ -782,77 +758,77 @@ Tyr Cys Pro Gln His Leu Ile Lys Met Phe Thr Trp Val - - + d="M2542.1 628.975C2532.43 625.895 2532.43 625.895 2532.43 625.895L2542.22 623.224L2539.73 626.049L2542.1 628.975Z" + stroke="black" + stroke-width="2.66667" /> + + + fill="black"> + id="Group 136"> O ₂ @@ -1257,21 +1231,21 @@ id="B_EX_pi_e" fill-rule="evenodd" clip-rule="evenodd" - d="m 120.431,1303.49 9.456,-2.96 -9.456,-2.97 2.364,2.97 z" - stroke="#000000" + d="M120.431 1303.49L129.887 1300.53L120.431 1297.56L122.795 1300.53L120.431 1303.49Z" + stroke="black" stroke-width="2.85342" /> O @@ -1332,21 +1306,21 @@ id="F_PHLACHt" fill-rule="evenodd" clip-rule="evenodd" - d="m 58.72,1205.25 -9.6484,2.96 9.6484,2.96 -2.4122,-2.96 z" - stroke="#000000" + d="M58.72 1205.25L49.0716 1208.21L58.72 1211.17L56.3078 1208.21L58.72 1205.25Z" + stroke="black" stroke-width="2.32327" /> CO + id="Group 119"> hcarn + id="Group 118"> 4abut + id="Group 120"> anth + id="creatine"> Orn Arg HO ₂ NH Ci Gly GA Creatine SAM CreatineP ATP ADP Creatinine H Pi + id="Group 129"> DHF NADP ⁺ H NADPH @@ -1965,87 +1934,87 @@ id="Group 128"> Folate NADP ⁺ H NADPH H ⁺ HO ₂ HO ₂ NADP ⁺ NADPH CO ₂ H ⁺ Formate THF Pi ADP ATP @@ -2386,92 +2355,92 @@ id="B_r0963" fill-rule="evenodd" clip-rule="evenodd" - d="m 105.085,1962.98 9.736,-2.98 -9.756,-2.91 2.447,2.93 z" - stroke="#000000" + d="M105.085 1962.98L114.821 1960L105.065 1957.09L107.512 1960.02L105.085 1962.98Z" + stroke="black" stroke-width="2.32759" /> 5,10mTHF 5,10meTHF NADH NAD ⁺ @@ -2479,54 +2448,54 @@ id="Group 124"> NADPH NADP ⁺ @@ -2534,355 +2503,348 @@ id="Group 122"> 2 H NH ₃ 5forthf NADPH 2 H NADP 5mTHF + id="path_aa_synthesis"> Amino acids synthesis / degradation - - + fill="#25CA25" /> + + Pentose Phosphate pathway - - + fill="#841BD7" /> + + Nucleotide synthesis - - + fill="#29BC90" /> + + Fatty acids / Cholesterol synthesis - - + fill="#CBE048" /> + + Urea cycle - - + fill="#C19C91" /> + + Ammonia detox - - + fill="#C19C91" /> + + - - + fill="#F018CE" /> + + Fatty acids β-oxidation - - + fill="#CBE048" /> + + Glutathione synthesis - - + fill="#AEAEAE" /> + + Glycolysis / Gluconeogenesis - - + transform="matrix(0 1 1 0 98 392)" + fill="#DA8F38" /> + + Ala AKG Glu - - + d="M626 838L623.5 834.5V839.5L624.796 837.632L626 838ZM293.5 964.501L286 970.001L295 969.001L292 968.001L293.5 964.501Z" + stroke="black" + stroke-width="2.23952" /> + + GSSG GSH H ⁺ NADH NAD ⁺ HO ₂₂ GSH 2 HO ₂ GSH NADP ⁺ GSH H ⁺ NADPH GC Cys ATP Gly Pi ADP ATP Glu Pi ADP + id="space_mitochondria"> Mitochondrial space - - + fill="#0A0A0A" /> + + Glc Glc G6P F6P F1,6BP GA3P ATP NAD ⁺ NADH ATP ADP Pi HO ₂ HO ₂ Pi 1,3BPGA 3PG 2PG ADP ATP HO ₂ Pi Pyr ADP ATP H ⁺ NADH NAD ⁺ HO ₂ Putr - + letter-spacing="0em">Putr + ametam spermidine - + letter-spacing="0em">spermidine + ametam 5mta spermine - + letter-spacing="0em">spermine + ⁺ ₂ CO 5mdr1p + letter-spacing="0em">5mdr1p 5mdru1p - + letter-spacing="0em">5mdru1p + ₂ HO dkmpp + letter-spacing="0em">dkmpp met - + letter-spacing="0em">met + 2 H ⁺ Glu + id="Group 167"> HO ATP Pi PPi SAM - + letter-spacing="0em">SAM + THF 5mTHF SAH - + letter-spacing="0em">SAH + HO Adenosine - - + d="M2023 252.5C2021.24 243.126 2021.27 244.048 2021.27 244.048L2018.78 253.213L2021 251L2023 252.5ZM2002.56 261.603C1992.75 264.223 1992.75 264.223 1992.75 264.223L2002.4 267.354L2000.05 264.415L2002.56 261.603Z" + stroke="black" + stroke-width="2.23952" /> + + Pi PRPP PPi - - + d="M2341 594.128C2350.22 591.308 2350.23 591.308 2350.23 591.308L2341.07 588.279L2343.33 591.23L2341 594.128ZM2296.75 579.686C2294.94 570.322 2294.94 570.322 2294.94 570.322L2292.5 579.5L2294.71 577.275L2296.75 579.686Z" + stroke="black" + stroke-width="2.23952" /> + + H ADP AMP - - + d="M2021.09 229.485V208.152C2021.09 208.152 2038.41 208.152 2049.5 208.152M2093 208.152C2093 208.152 2066.49 208.152 2049.5 208.152M2021.09 188.5C2021.09 208.152 2034.5 208.152 2034.5 208.152M2064 208.152C2091 208.152 2091 188.5 2091 188.5M2049.5 208.152C2064 208.152 2064 188.5 2064 188.5" + stroke="black" + stroke-width="2.23952" /> + + Hcys 5mTHF THF + id="Group 164"> ₂ H ₂ O Pi ⁺ 2 H formate 2kmb - + letter-spacing="0em">2kmb + Glu AKG Putr - + letter-spacing="0em">Putr + + id="Group 148"> spermine + id="Group 149"> + id="Group 150"> ₂ CO + id="Group 153"> hcarn ATP AMP PPi 2 H ⁺ - - + d="M1926.7 600.67C1933.88 601.559 1933.88 601.559 1933.88 601.559L1928.64 596.563L1929.22 599.352L1926.7 600.67ZM1926.7 585.737C1933.88 586.626 1933.88 586.626 1933.88 586.626L1928.64 581.63L1929.22 584.419L1926.7 585.737ZM1926.7 562.27C1933.88 563.159 1933.88 563.159 1933.88 563.159L1928.64 558.163L1929.22 560.952L1926.7 562.27ZM1912.88 606.784C1916.14 616.398 1916.14 616.398 1916.14 616.398L1918.63 606.559L1915.85 609.103L1912.88 606.784Z" + stroke="black" + stroke-width="2.66667" /> + + ₂ HO His - - + d="M1986.55 571.054C1991.67 565.939 1991.67 565.939 1991.67 565.939L1984.5 567L1987.06 568.255L1986.55 571.054ZM1949.89 535C1940 537.283 1940 537.283 1940 537.283L1949.54 540.742L1947.29 537.724L1949.89 535Z" + stroke="black" + stroke-width="2.66667" /> + + 4abutn ₂ HO NAD ⁺ - - + d="M1960 523C1962.33 516.15 1962.33 516.15 1962.33 516.15L1964.54 523.049L1962.29 521.306L1960 523ZM1949.66 534.204C1940 531.076 1940 531.076 1940 531.076L1949.81 528.453L1947.3 531.265L1949.66 534.204Z" + stroke="black" + stroke-width="2.66667" /> + + ₂ H NADH Glu + id="g76852"> ₂ H ₂ O ₂₂ ₃ NH - - + d="M2071.52 586.431L2064.35 585.404L2069.5 590.5L2068.97 587.7L2071.52 586.431ZM2073.21 560.676L2066.04 559.649L2071.19 564.745L2070.66 561.945L2073.21 560.676ZM2086.5 551.5L2084 546.5L2082 551.5L2084 550.5L2086.5 551.5Z" + stroke="black" + stroke-width="2.66667" /> + + 2obut + id="Group 23"> 6Pgl NADP NADPH H ⁺ NADP NADPH CO ₂ H ⁺ HO ₂ AMP ATP R5P Xil5P Sed7P F6P Sed1,7BP Ery4P DHAP ATP ADP Ery4P GA3P F6P + id="Group 24"> ADP ATP PRPP Gly 2 10fTHF 2 THF PPi 4 ADP Fum 2 Gln 2 Glu 4 ATP O CO Asp 2 ATP QH ₂ 2 ADP Gln Glu HCO ₃ Q H PPi CO UDP ATP ADP O dUMP ADP ATP dTMP 5,10meTHF DHF UTP CTP ADP Pi NH HO ₂ dCDP ATP ADP @@ -7279,50 +7175,50 @@ id="B_URIDK2r" fill-rule="evenodd" clip-rule="evenodd" - d="m 1276.45,409.448 c -1.83,5.701 -1.83,5.701 -1.83,5.701 l -1.28,-5.879 1.49,1.536 z m -7,-6.152 c -7.55,-2.358 -7.55,-2.358 -7.55,-2.358 l 7.62,-2.124 -1.93,2.212 z" - stroke="#000000" + d="M1276.45 409.448C1274.62 415.149 1274.62 415.149 1274.62 415.149L1273.34 409.27L1274.83 410.806L1276.45 409.448ZM1269.45 403.296C1261.9 400.938 1261.9 400.938 1261.9 400.938L1269.52 398.814L1267.59 401.026L1269.45 403.296Z" + stroke="black" stroke-width="1.95125" /> UMP GMP GDP 2 AMP ADP ADP O dADP ADP ATP dGTP ADP @@ -7586,25 +7482,25 @@ id="B_NDPK8" fill-rule="evenodd" clip-rule="evenodd" - d="m 1330.68,144.434 c -0.51,2.035 -1.01,4.069 -1.52,6.103 -0.82,-1.953 -1.63,-3.906 -2.45,-5.86 0.7,0.458 1.4,0.916 2.1,1.374 0.63,-0.539 1.25,-1.078 1.87,-1.617 z m -7.18,-9.825 c -2.5,-0.839 -5,-1.677 -7.5,-2.515 2.55,-0.655 5.11,-1.31 7.66,-1.964 -0.66,0.723 -1.32,1.447 -1.98,2.17 0.61,0.77 1.21,1.539 1.82,2.309 z" - fill="#2b0000" - stroke="#000000" + d="M1330.68 144.434C1330.17 146.469 1329.67 148.503 1329.16 150.537C1328.34 148.584 1327.53 146.631 1326.71 144.677C1327.41 145.135 1328.11 145.593 1328.81 146.051C1329.44 145.512 1330.06 144.973 1330.68 144.434ZM1323.5 134.609C1321 133.77 1318.5 132.932 1316 132.094C1318.55 131.439 1321.11 130.784 1323.66 130.13C1323 130.853 1322.34 131.577 1321.68 132.3C1322.29 133.07 1322.89 133.839 1323.5 134.609Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> dATP dCTP dTDP 4 Pi IMP 2 Pi @@ -7701,40 +7597,40 @@ id="B_TMDS" fill-rule="evenodd" clip-rule="evenodd" - d="m 1371.55,408.698 c -1.83,5.701 -1.83,5.701 -1.83,5.701 l -1.28,-5.879 1.49,1.536 z m -7,-5.997 c -7.55,-2.357 -7.55,-2.357 -7.55,-2.357 l 7.62,-2.124 -1.93,2.212 z" - fill="#2b0000" - stroke="#000000" + d="M1371.55 408.698C1369.72 414.399 1369.72 414.399 1369.72 414.399L1368.44 408.52L1369.93 410.056L1371.55 408.698ZM1364.55 402.701C1357 400.344 1357 400.344 1357 400.344L1364.62 398.22L1362.69 400.432L1364.55 402.701Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> ADP ATP @@ -7755,40 +7651,40 @@ id="B_DTMPK" fill-rule="evenodd" clip-rule="evenodd" - d="m 1523.81,408.854 c -1.83,5.7 -1.83,5.7 -1.83,5.7 l -1.28,-5.879 1.49,1.537 z m -7,-6.153 c -7.55,-2.357 -7.55,-2.357 -7.55,-2.357 l 7.62,-2.124 -1.93,2.212 z" - fill="#2b0000" - stroke="#000000" + d="M1523.81 408.854C1521.98 414.554 1521.98 414.554 1521.98 414.554L1520.7 408.675L1522.19 410.212L1523.81 408.854ZM1516.81 402.701C1509.26 400.344 1509.26 400.344 1509.26 400.344L1516.88 398.22L1514.95 400.432L1516.81 402.701Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> ADP ATP @@ -7809,39 +7705,39 @@ id="B_NDPK2" fill-rule="evenodd" clip-rule="evenodd" - d="m 1275.62,344.538 c -1.83,-5.7 -1.83,-5.7 -1.83,-5.7 l -1.28,5.879 1.48,-1.537 z m -7.01,6.153 c -7.54,2.358 -7.54,2.358 -7.54,2.358 l 7.61,2.123 -1.93,-2.211 z" - stroke="#000000" + d="M1275.62 344.538C1273.79 338.838 1273.79 338.838 1273.79 338.838L1272.51 344.717L1273.99 343.18L1275.62 344.538ZM1268.61 350.691C1261.07 353.049 1261.07 353.049 1261.07 353.049L1268.68 355.172L1266.75 352.961L1268.61 350.691Z" + stroke="black" stroke-width="1.95125" /> ADP ATP @@ -7862,29 +7758,29 @@ id="B_NDPK3" fill-rule="evenodd" clip-rule="evenodd" - d="m 1501.9,344.558 c -1.83,-5.701 -1.83,-5.701 -1.83,-5.701 l -1.28,5.88 1.49,-1.537 z m -16.35,6.152 c -7.55,2.358 -7.55,2.358 -7.55,2.358 l 7.62,2.124 -1.93,-2.212 z" - fill="#2b0000" - stroke="#000000" + d="M1501.9 344.558C1500.07 338.857 1500.07 338.857 1500.07 338.857L1498.79 344.737L1500.28 343.2L1501.9 344.558ZM1485.55 350.71C1478 353.068 1478 353.068 1478 353.068L1485.62 355.192L1483.69 352.98L1485.55 350.71Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> @@ -7892,61 +7788,61 @@ id="F_RNDR3" fill-rule="evenodd" clip-rule="evenodd" - d="m 1592.6,355.47 c 7.52,-2.457 7.52,-2.457 7.52,-2.457 l -7.64,-2.023 1.96,2.186 z m -5.1,-11.97 -2,-3.5 -1,4 1.5,-1 z" - fill="#2b0000" - stroke="#000000" + d="M1592.6 355.47C1600.12 353.013 1600.12 353.013 1600.12 353.013L1592.48 350.99L1594.44 353.176L1592.6 355.47ZM1587.5 343.5L1585.5 340L1584.5 344L1586 343L1587.5 343.5Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> GTP Asp GDP Pi NAD ⁺ O NH H AMP NADP ⁺ NH H ADP @@ -8262,37 +8158,37 @@ id="F_GK1" fill-rule="evenodd" clip-rule="evenodd" - d="m 1538.3,243.915 c 2.04,-0.508 4.07,-1.016 6.11,-1.525 -1.96,-0.816 -3.91,-1.632 -5.86,-2.449 0.46,0.701 0.91,1.402 1.37,2.103 -0.54,0.624 -1.08,1.247 -1.62,1.871 z m -9.82,-13.418 c -0.84,-2.499 -1.68,-4.998 -2.52,-7.497 -0.65,2.553 -1.31,5.107 -1.96,7.66 0.72,-0.659 1.45,-1.317 2.17,-1.976 0.77,0.604 1.54,1.209 2.31,1.813 z" - fill="#2b0000" - stroke="#000000" + d="M1538.3 243.915C1540.34 243.407 1542.37 242.899 1544.41 242.39C1542.45 241.574 1540.5 240.758 1538.55 239.941C1539.01 240.642 1539.46 241.343 1539.92 242.044C1539.38 242.668 1538.84 243.291 1538.3 243.915ZM1528.48 230.497C1527.64 227.998 1526.8 225.499 1525.96 223C1525.31 225.553 1524.65 228.107 1524 230.66C1524.72 230.001 1525.45 229.343 1526.17 228.684C1526.94 229.288 1527.71 229.893 1528.48 230.497Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> @@ -8300,61 +8196,61 @@ id="B_NDPK5" fill-rule="evenodd" clip-rule="evenodd" - d="m 1567.52,150.716 c 1.61,-6.716 1.61,-6.716 1.61,-6.716 l 2.24,6.524 -2,-1.559 z m -7.99,14.514 c -7.53,-2.416 -7.53,-2.416 -7.53,-2.416 l 7.63,-2.065 -1.94,2.197 z" - fill="#2b0000" - stroke="#000000" + d="M1567.52 150.716C1569.13 144 1569.13 144 1569.13 144L1571.37 150.524L1569.37 148.965L1567.52 150.716ZM1559.53 165.23C1552 162.814 1552 162.814 1552 162.814L1559.63 160.749L1557.69 162.946L1559.53 165.23Z" + fill="#2B0000" + stroke="black" stroke-width="1.95125" /> ADP ATP + id="Group 25"> ATP HCO ⁻ ₃ H ⁺ ADP Pi CoA AcACP ACP CO ₂ ACP MalCoA CoA MalACP ACP AcCoA HO ₂ CoA AcAcCoA PalmCoA CoA AMP PPi ATP Palm @@ -8854,11 +8749,11 @@ id="Group 76"> AcAcACP 14 NADPH 14 NADP ⁺ 6 HO ₂ 6 CO ₂ 6 MalACP 7 ACP 14 H ⁺ HMGCoA 3 ATP CoA 2 NADPH 2 NADP ⁺ 3 ADP CO ₂ Pi 2 PPi fPP 2 ippPP ippPP 13 NADPH 2 10 O 13 NADP ⁺ 2 PPi formate 2 CO ₂ Chol fPP 15 HO ₂ 16 H ⁺ HMGCoA AcCoA CoA + id="Group 26"> 3 Ci 3 H ⁺ ⁻ ₃ 2 ADP Pi 2 ATP H H Ci CP Pi Orn - - - + d="M1736.5 1145L1735 1147.5L1734.5 1144L1735.65 1145H1736.5ZM1728.74 1137.34C1723.15 1135.41 1723.15 1135.41 1723.15 1135.41L1728.89 1134L1727.4 1135.61L1728.74 1137.34Z" + stroke="black" + stroke-width="2.23952" /> + + + Pi H Pi ATP ADP ATP ADP GTP GDP GTP HO HO O ₂ O ₂ @@ -10159,444 +10052,444 @@ id="F_O2tm" fill-rule="evenodd" clip-rule="evenodd" - d="m 755.206,1269.9 c 9.221,-2.82 9.221,-2.82 9.221,-2.82 l -9.155,-3.03 2.264,2.95 z" - stroke="#000000" + d="M755.206 1269.9C764.427 1267.08 764.427 1267.08 764.427 1267.08L755.272 1264.05L757.536 1267L755.206 1269.9Z" + stroke="black" stroke-width="2.61244" /> NADH NAD ⁺ 0.95 QH ₂ 4.75 H ⁺ 0.95 Q 3.8 H ⁺ FADH ₂ FAD QH ₂ Q 2 Cytc-ox 2 Cytc-red Q 2 H ⁺ QH ₂ 4 H ⁺ 4 Cytc-red 4 Cytc-ox 2 HO ₂ 8 H ⁺ O ₂ GSH GSH Pi Pi Gly Gly Mal AKG AKG ADP Pi ATP HO ₂ 4 H ⁺ 10-formylTHF HO ₂ 5,10meTHF NADPH NADP ⁺ H ⁺ THF HO ₂ CO CO NADH NADP NAD H H O ₂ O O ₂ ⁻ O ₂ 2 H O GSSG H NAD ⁺ H NADP ⁺ CO HCO ₃ H O Ser Ser 0.05 O ₂ 0.05 O ₂ ⁻ DHAP DHAP FAD FADH Gly3P Gly3P AcCoA Pyr NAD ⁺ NADP ⁺ NADH CO ₂ H ⁺ Pi H ATP HCO ₃ NAD ⁺ CoA 2 CO H ⁺ NADH NADPH H ⁺ CO ₂ @@ -12436,27 +12329,27 @@ id="B_H2Otm" fill-rule="evenodd" clip-rule="evenodd" - d="m 1897.58,2052.92 c 9.23,2.82 9.23,2.82 9.23,2.82 l -9.16,3.03 2.26,-2.95 z" - stroke="#000000" + d="M1897.58 2052.92C1906.81 2055.74 1906.81 2055.74 1906.81 2055.74L1897.65 2058.77L1899.91 2055.82L1897.58 2052.92Z" + stroke="black" stroke-width="2.61244" /> ATP Formate Formate H ⁺ H ⁺ H ⁺ H OAA Cit Isocit NADP ⁺ SuCoA Succ Fum Mal FADH NAD ⁺ O CoA O H GDP Pi CoA GTP NAD NADH CO H NADPH CO H NAD ⁺ NADH ⁺ H ⁺ CO ₂ @@ -13425,75 +13318,75 @@ id="B_ACONTm" fill-rule="evenodd" clip-rule="evenodd" - d="m 1187.25,1346.98 c -10.25,2.35 -10.25,2.35 -10.25,2.35 l 7.1,-6.7 -0.59,3.31 z" - stroke="#000000" + d="M1187.25 1346.98C1177 1349.33 1177 1349.33 1177 1349.33L1184.1 1342.63L1183.51 1345.94L1187.25 1346.98Z" + stroke="black" stroke-width="2.56963" /> H NH NAD ⁺ O H NH NADP ⁺ O NADP NADPH H ⁺ DHF NADP H ⁺ Folate 4 H ⁺ 4 H ⁺ H HO ₂ NAD ⁺ Gln Glu Gln NH ₃ O H ⁺ H ⁺ H ⁺ H ⁺ Folate + d="M1384.57 932.624L1390.76 953.522L1384.46 948.008L1377.68 953.279L1384.57 932.624ZM1382.32 946.722L1384.54 944.992L1386.24 946.479L1384.43 940.376L1382.32 946.722ZM1275.34 992.418L1274.21 995.427L1275.34 996.959V992.418ZM1272.96 992.137L1275.41 985.592L1277.66 986V1004.04L1268.56 991.691L1270.2 990.069L1272.96 992.137ZM1130.38 1533.69L1126.37 1538.91L1130.49 1544.05L1114.16 1539.05L1130.38 1533.69ZM1121.84 1538.96L1123.94 1539.61L1123.41 1538.95L1123.93 1538.27L1121.84 1538.96Z" + fill="black" /> + Mal Fum Pi Pi Fum @@ -14464,11 +14357,11 @@ id="Group 57"> GluSA Val, 3mob, propCoA @@ -14570,12 +14463,12 @@ id="Group 40"> Leu Leu Val Val H ⁺ H ⁺ Lys 3mob 3mob H ⁺ H ⁺ 4mop 4mop H ⁺ H ⁺ 2oxoadp 2oxoadp AKG AKG @@ -14995,56 +14888,56 @@ id="Group 39"> propCoA propCoA 5,10meTHF 5,10meTHF AKG Asp H H Glu AcAcCoA CoA 2 AcCoA NAD ⁺ H @@ -15394,43 +15287,43 @@ id="use1272-2-48"> HMGCoA Leu, 4mop Lys, 2oxoadp AcCoA O CoA H HO + id="Group 28"> Ci Orn ArgSuc Arg Fum HO ₂ @@ -15725,28 +15617,28 @@ id="Group 144"> Urea @@ -15756,22 +15648,22 @@ id="F_NH4t" fill-rule="evenodd" clip-rule="evenodd" - d="m 1807.89,35.2407 -2.95,-9.2406 -2.94,9.2406 2.94,-2.3101 z" - stroke="#000000" + d="M1807.89 35.2407L1804.94 26.0001L1802 35.2407L1804.94 32.9306L1807.89 35.2407Z" + stroke="black" stroke-width="3.3745" /> 3 + id="Group 30"> PalmCarn PalmCarn Carn Carn PalmCoA Carn CoA 8 AcCoA 7 FAD 7 NAD 7 HO 7 FADH ₂ 7 NADH 7 H ⁺ - - + d="M1450.52 1808.51C1451.36 1817 1451.36 1817 1451.36 1817L1454.26 1809.03L1452.13 1810.83L1450.52 1808.51ZM1501.62 1808.51C1502.46 1817 1502.46 1817 1502.46 1817L1505.36 1809.03L1503.23 1810.83L1501.62 1808.51ZM1543.26 1808.51C1544.1 1817 1544.1 1817 1544.1 1817L1547 1809.03L1544.87 1810.83L1543.26 1808.51ZM1404.5 1795L1396 1798L1404.5 1801L1403 1798L1404.5 1795Z" + stroke="black" + stroke-width="2.23952" /> + + H CO ₂ HCO ₃ HO ₂ ADP Pi HO ₂ ATP H ⁺ PPi Pi Pi HO ₂ - - + d="M2527.61 2026.74C2537.28 2023.64 2537.28 2023.64 2537.28 2023.64L2527.48 2020.99L2529.98 2023.81L2527.61 2026.74ZM2519.95 2010.42C2518.17 2001.05 2518.17 2001.05 2518.17 2001.05L2515.69 2010.22L2517.91 2008L2519.95 2010.42Z" + stroke="black" + stroke-width="2.23952" /> + + 0.01 dTTP 0.01 dATP 0.01 dGTP 0.05 UTP 0.01 dCTP 0.04CTP 0.27 Palm 20.65 H20 20.70 ATP 0.04 GTP 0.36 Arg 0.05 Cys 0.39 Glu 0.35 Asp 0.33 Gln 0.28 Asn 0.29 Ile 0.12 His 0.54 Gly 0.59Lys 0.41 Pro 0.26 Phe 0.15 Met 0.55 Leu 0.01 Trp 0.31Thr 0.16 Tyr 0.35Val 0.39 Ser 0.51 Ala Biomass 20.65 Pi 20.65ADP 20.65 H + d="M2287.26 1076.98L2285.97 1452.13L2287.26 1076.98Z" + fill="black" /> - - + d="M2278.69 1068.05L2275.54 1077.7L2278.49 1075.35L2281.29 1077.86L2278.69 1068.05ZM2374.86 1073.25L2377.21 1076.19L2374.69 1079L2384.5 1076.4L2374.86 1073.25ZM2194.56 1093.88L2184.75 1096.48L2194.4 1099.63L2192.05 1096.68L2194.56 1093.88ZM2376.81 1102.62L2379.16 1105.57L2376.64 1108.37L2386.46 1105.77L2376.81 1102.62Z" + stroke="black" + stroke-width="2.66667" /> + + H ⁺ NADH Gly3P + id="Group 71"> GTP CO ₂ GDP AKG Iso NADPH H ⁺ NADP ⁺ CO ₂ @@ -17103,60 +16990,60 @@ id="Group 70"> ATP CoA Pi ADP + d="M1377.53 823.782L1389.88 827.901L1385.16 829.788V834.692L1377.53 823.782ZM1367.72 833.347L1363.75 838.596L1367.9 843.706L1351.54 838.804L1367.72 833.347ZM1359.21 838.673L1361.32 839.305L1360.79 838.646L1361.3 837.969L1359.21 838.673ZM1414.43 840.977L1428.52 845.38L1412.78 851.499L1417.11 845.444L1414.43 840.977ZM1419.57 845.023L1419.89 845.556L1419.22 846.501L1421.48 845.62L1419.57 845.023ZM1136.61 852.404L1137.73 854.409L1133.68 857.643L1139.46 864.136L1119.1 858.656L1136.61 852.404ZM1126.9 858.344L1132.54 859.864L1130.32 857.357L1130.84 856.934L1126.9 858.344Z" + fill="black" /> Mal Glu Asp Fum NH ₃ NADPH H ⁺ CO ₂ NADP ⁺ @@ -17369,11 +17256,11 @@ id="Group 66"> H ⁺ NADH NAD ⁺ HO ₂ + id="Group 88"> 3PPyr NADH H ⁺ NAD ⁺ - - + d="M280.899 728C271.116 730.705 271.116 730.705 271.116 730.705L280.798 733.752L278.415 730.833L280.899 728ZM362 739.214C363.75 748.59 363.75 748.59 363.75 748.59L366.252 739.428L364.032 741.638L362 739.214Z" + stroke="black" + stroke-width="2.23952" /> + + CySS 2 GSH GSSG 2 Cys H ⁺ NADPH NADP NADH H ⁺ NAD HO ₂ NH ₃ Pyr - - + d="M806.5 531.628L804 529L804.5 534L805.137 531.628L806.5 531.628Z" + stroke="black" + stroke-width="2.66667" /> + + Asn AMP Glu PPi ATP Gln HO ₂ HO ₂ NH ₃ Asp + id="Group 116"> P5C Pro H ⁺ NADH H ⁺ NADPH NAD ⁺ NADP ⁺ HO ₂ - - - + d="M1246.53 591.078C1254.95 594.102 1254.95 594.102 1254.95 594.102L1246.3 596.311L1248.55 593.797L1246.53 591.078ZM1228.11 584.486C1229.33 575.026 1229.33 575.026 1229.33 575.026L1232.34 584.033L1230 581.951L1228.11 584.486Z" + stroke="black" + stroke-width="2.23952" /> + + + NH ₃ HO ₂ NH ATP ADP Pi + id="Group 96"> O ₂ Trp Lfmkynr + id="Group 95"> formate H ⁺ HO ₂ Glu + letter-spacing="0em">Glu urcan - + letter-spacing="0em">urcan + NH ₃ His + id="Group 111"> HO ₂ 4izp + letter-spacing="0em">4izp forglu - - forglu + + H ⁺ 5forthf - + font-size="12" + letter-spacing="0em">5forthf + H HO ₂ THF + font-size="12" + letter-spacing="0em">THF hgentis - + letter-spacing="0em">hgentis + hpp O ₂ CO ₂ - - + d="M1015.92 596.889C1018.13 590 1018.13 590 1018.13 590L1020.46 596.86L1018.17 595.156L1015.92 596.889ZM1011.76 610.309C1002 607.53 1002 607.53 1002 607.53L1011.7 604.557L1009.3 607.457L1011.76 610.309Z" + stroke="black" + stroke-width="2.66667" /> + + 4mlacac O ₂ H ⁺ - - + d="M968.5 566.133C960.64 568.308 960.64 568.308 960.64 568.308L967.5 570.633L965.796 568.349L968.5 566.133ZM977.665 560.762C974.886 551 974.886 551 974.886 551L971.913 560.705L974.813 558.3L977.665 560.762Z" + stroke="black" + stroke-width="2.66667" /> + + 4fumacac - - + d="M1030.72 544.752C1040.48 541.973 1040.48 541.973 1040.48 541.973L1030.77 539L1033.18 541.9L1030.72 544.752Z" + stroke="black" + stroke-width="2.66667" /> + + HO ₂ H ⁺ Fum AcAc - - + d="M1182.1 545.565C1191.86 542.786 1191.86 542.786 1191.86 542.786L1182.15 539.813L1184.56 542.713L1182.1 545.565ZM1156.22 533.849C1154 526.96 1154 526.96 1154 526.96L1151.68 533.82L1153.96 532.116L1156.22 533.849Z" + stroke="black" + stroke-width="2.66667" /> + + CoA ATP PPi AMP AcAcCoA - - + d="M1334.67 545.87C1344.43 543.091 1344.43 543.091 1344.43 543.091L1334.73 540.118L1337.13 543.018L1334.67 545.87ZM1313.5 535.5C1311.28 528.611 1311.78 529.611 1311.78 529.611L1310 535.5L1311.74 534.767L1313.5 535.5Z" + stroke="black" + stroke-width="2.66667" /> + + Lkynr anth H ⁺ HO ₂ + id="Group 93"> 2oxoadp Thr - + letter-spacing="0em">Thr + NH ₃ + id="use1272-8-6-2"> 2obut + letter-spacing="0em">2obut propCoA - + letter-spacing="0em">propCoA + CoA NAD NADH CO ₂ - - + d="M1349.9 768.503C1359.66 765.724 1359.66 765.724 1359.66 765.724L1349.95 762.751L1352.36 765.651L1349.9 768.503ZM1332.26 755.083C1330.04 748.194 1330.04 748.194 1330.04 748.194L1327.72 755.054L1330 753.35L1332.26 755.083Z" + stroke="black" + stroke-width="2.66667" /> + + Tyr AKG Glu + id="Group 117"> 3mob Val Glu AKG + id="Group 102"> 4mop Leu Glu AKG + id="Group 90"> Cyst Cys NH ₃ 2-obut HO ₂ HO ₂ Hcys + id="Group 85"> Gly THF HO ₂ 5,10meTHF - - + d="M810.34 731.323C818.751 734.368 818.75 734.368 818.75 734.368L810.092 736.556L812.35 734.047L810.34 731.323ZM801.363 722.714C803.114 713.338 803.114 713.338 803.114 713.338L805.616 722.5L803.396 720.29L801.363 722.714Z" + stroke="black" + stroke-width="2.23952" /> + + HO ₂ Pi - - + d="M666.323 735.233C674.733 732.187 674.733 732.187 674.733 732.187L666.074 730L668.332 732.509L666.323 735.233ZM648.08 747.817C649.83 757.193 649.83 757.193 649.83 757.193L652.332 748.031L650.112 750.241L648.08 747.817Z" + stroke="black" + stroke-width="2.23952" /> + + NH ₃ + id="Group 87"> 3PSer Glu AKG - - - AC - ATP - CoA - - + d="M487.526 729.098C479.116 732.143 479.116 732.143 479.116 732.143L487.775 734.33L485.517 731.821L487.526 729.098ZM499.88 748.676C501.631 758.052 501.631 758.052 501.631 758.052L504.133 748.89L501.913 751.1L499.88 748.676Z" + stroke="black" + stroke-width="2.23952" /> + + AC + ATP + CoA + + +