--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/cobraxy-9688ad27287b/COBRAxy/utils/CBS_backend.py	Sun Oct 13 11:39:53 2024 +0000
@@ -0,0 +1,200 @@
+from swiglpk import *
+import random
+import pandas as pd
+import numpy as np
+import cobra as cb
+
+# Initialize LP problem
+def initialize_lp_problem(S):
+
+    len_vector=len(S.keys())
+    values=list(S.values())
+    indexes=list(S.keys())
+    ia = intArray(len_vector+1); 
+    ja = intArray(len_vector+1);
+    ar = doubleArray(len_vector+1);
+    
+    i=0
+    ind_row=[indexes[i][0]+1 for i in range(0, len(values) )]
+    ind_col=[indexes[i][1]+1 for i in range(0, len(values) )]
+    for i in range(1, len(values) + 1): 
+        ia[i]=ind_row[i-1]
+        ja[i]=ind_col[i-1]
+        ar[i] = values[i-1]
+    
+    nrows=S.shape[0]
+    ncol=S.shape[1]
+    
+    return len_vector, values, indexes, ia, ja, ar, nrows, ncol
+    
+    
+
+# Solve LP problem from the structure of the metabolic model
+def create_and_solve_lp_problem(lb,ub,nrows, ncol, len_vector, ia, ja, ar, 
+                                obj_coefs,reactions,return_lp=False):
+    
+    
+    lp = glp_create_prob();
+    glp_set_prob_name(lp, "sample");
+    glp_set_obj_dir(lp, GLP_MAX);
+    glp_add_rows(lp, nrows);
+    eps = 1e-16
+    for i in range(nrows):
+        glp_set_row_name(lp, i+1, "constrain_"+str(i+1));
+        glp_set_row_bnds(lp, i+1, GLP_FX, 0.0, 0.0);
+    glp_add_cols(lp, ncol);
+    for i in range(ncol):
+        glp_set_col_name(lp, i+1, "flux_"+str(i+1));
+        glp_set_col_bnds(lp, i+1, GLP_DB,lb[i]-eps,ub[i]+eps);
+    glp_load_matrix(lp, len_vector, ia, ja, ar);
+    
+    try:
+        fluxes,Z=solve_lp_problem(lp,obj_coefs,reactions)
+        if return_lp:
+            return fluxes,Z,lp
+        else:
+            glp_delete_prob(lp);
+            return fluxes,Z
+    except Exception as e:
+        glp_delete_prob(lp)
+        raise Exception(e)
+    
+    
+# Solve LP problem from the structure of the metabolic model
+def solve_lp_problem(lp,obj_coefs,reactions):
+   
+    # Set the coefficients of the objective function
+    i=1
+    for ind_coef in obj_coefs:
+        glp_set_obj_coef(lp, i, ind_coef);
+        i+=1
+
+    # Initialize the parameters    
+    params=glp_smcp()
+    params.presolve=GLP_ON
+    params.msg_lev = GLP_MSG_ALL
+    params.tm_lim=4000
+    glp_init_smcp(params)
+    
+    # Solve the problem
+    glp_scale_prob(lp,GLP_SF_AUTO)
+    
+    value=glp_simplex(lp, params) 
+
+    Z = glp_get_obj_val(lp);
+
+    if value == 0:
+        fluxes = []
+        for i in range(len(reactions)): fluxes.append(glp_get_col_prim(lp, i+1))
+        return fluxes,Z
+    else:
+        raise Exception("error in LP problem. Problem:",str(value)) 
+    
+
+# Create LP structure
+def create_lp_structure(model):
+    
+    reactions=[el.id for el in model.reactions]
+    coefs_obj=[reaction.objective_coefficient for reaction in model.reactions]
+    
+    # Lower and upper bounds
+    lb=[reaction.lower_bound for reaction in model.reactions]
+    ub=[reaction.upper_bound for reaction in model.reactions]
+    
+    # Create S matrix
+    S=cb.util.create_stoichiometric_matrix(model,array_type="dok")
+    
+    return S,lb,ub,coefs_obj,reactions
+
+# CBS sampling interface
+def randomObjectiveFunctionSampling(model, nsample, coefficients_df, df_sample):
+
+    S,lb,ub,coefs_obj,reactions = create_lp_structure(model)
+    len_vector, values, indexes, ia, ja, ar, nrow, ncol = initialize_lp_problem(S)
+    
+    for i in range(nsample):
+      
+        coefs_obj=coefficients_df.iloc[:,i].values
+            
+        if coefs_obj[-1]==1: #minimize
+            coefs_obj= coefs_obj[0:-1] * -1
+        else:
+            coefs_obj=coefs_obj[0:-1]
+
+        fluxes,Z = create_and_solve_lp_problem(lb,ub, nrow, ncol, len_vector, 
+                                                        ia, ja, ar, coefs_obj,reactions,return_lp=False)
+        df_sample.loc[i] = fluxes 
+    pass
+
+def randomObjectiveFunctionSampling_cobrapy(model, nsample, coefficients_df, df_sample):
+    
+    for i in range(nsample):
+
+        dict_coeff={}
+        if(coefficients_df.iloc[-1][i]==1):
+            type_problem = -1 #minimize
+        else:
+            type_problem = 1
+            
+        for rxn in [reaction.id for reaction in model.reactions]:
+            dict_coeff[model.reactions.get_by_id(rxn)] = coefficients_df.loc[rxn][i] * type_problem
+            
+        model.objective = dict_coeff
+        solution =  model.optimize().fluxes
+        for rxn, flux in solution.items():
+            df_sample.loc[i][rxn] = flux
+
+    pass
+
+# Create random coefficients for CBS
+def randomObjectiveFunction(model, n_samples, df_fva, seed=0):
+    
+
+        #reactions = model.reactions
+        reactions = [reaction.id for reaction in model.reactions]
+        cont=seed
+        list_ex=reactions.copy()
+        list_ex.append("type_of_problem")
+        coefficients_df = pd.DataFrame(index=list_ex,columns=[str(i) for i in range(n_samples)])
+
+        for i in range(0, n_samples):
+           
+            cont=cont+1
+            random.seed(cont)
+            
+            # Genera un numero casuale tra 0 e 1
+            threshold = random.random() #coefficiente tra 0 e 1
+            
+            for reaction in reactions:
+
+                cont=cont+1
+                random.seed(cont)
+                        
+                val=random.random()   
+                
+                if val>threshold:
+
+                    cont=cont+1
+                    random.seed(cont)                           
+                   
+                    c=2*random.random()-1 #coefficiente tra -1 e 1
+                    
+                    val_max=np.max([df_fva.loc[reaction,"minimum"],df_fva.loc[reaction,"maximum"]])
+                    
+                    if val_max!=0: #solo se la fva è diversa da zero
+                        coefficients_df.loc[reaction,str(i)] = c/val_max #divido per la fva
+                    else:
+                        coefficients_df.loc[reaction,str(i)] = 0
+
+                else:
+                    coefficients_df.loc[reaction,str(i)] = 0
+
+            cont=cont+1
+            random.seed(cont)
+                    
+            if random.random()<0.5:
+                coefficients_df.loc["type_of_problem",str(i)] = 0 #maximize
+            else:
+                coefficients_df.loc["type_of_problem",str(i)] = 1 #minimize
+                            
+        return coefficients_df
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/GSOC project submission.html	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,65 +0,0 @@
-<!DOCTYPE html>
-<html lang="en">
-<head>
-    <meta charset="UTF-8">
-    <meta name="viewport" content="width=device-width, initial-scale=1.0">
-    <title>Google Summer of Code 2024 - COBRAxy: COBRA and MaREA4Galaxy</title>
-    <link href="https://cdn.jsdelivr.net/npm/bootstrap@5.3.1/dist/css/bootstrap.min.css" rel="stylesheet">
-</head>
-<body>
-    <div class="container my-5">
-        <h1 class="text-center mb-4">Google Summer of Code 2024</h1>
-        <h2 class="text-center mb-4">COBRAxy: COBRA and MaREA4Galaxy</h2>
-        <p><strong>National Resource for Network Biology (NRNB)</strong></p>
-        <p><strong>Mentors:</strong></p>
-        <ul>
-            <li>Alex Graudenzi, alex.graudenzi@unimib.it</li>
-            <li>Chiara Damiani, chiara.damiani@unimib.it</li>
-            <li>Marco Antoniotti, marco.antoniotti@unimib.it</li>
-        </ul>
-        <p><strong>Contributor:</strong></p>
-        <ul>
-            <li>Luca Milazzo (University of Milano-Bicocca) – lucmil2000@gmail.com, luca.milazzo@epfl.ch</li>
-        </ul>
-
-        <h3 class="mt-4">Project Description</h3>
-        <p>
-            The project focused on developing an advanced Galaxy tool that enhances the data mapping capabilities of MaREA4Galaxy. The extension of this framework includes the analysis of fluxomics data, starting from a metabolic model and progressing to the representation of up-regulated fluxes on a metabolic map. This tool enables users to perform constraint-based enrichment analysis of metabolic pathways.
-        </p>
-        <p>The primary goals of the project were:</p>
-        <ul>
-            <li>Create a flux sampling and analysis interface to allow users to work with constraint-based metabolic models (e.g., sampling algorithms, FBA, pFBA, and FVA).</li>
-            <li>Adapt the existing clustering module to clusterize fluxomics data and implement additional clustering algorithms (e.g., Leiden and Louvain).</li>
-            <li>Build upon the existing module for visualizing enriched reactions based on RAS to create a new module for enrichment analysis of metabolic pathways based on simulated fluxomics data, and visualize the results on the metabolic map.</li>
-        </ul>
-
-        <h3 class="mt-4">What I Did</h3>
-        <ul>
-            <li>Updated all existing modules of MaREA4Galaxy to use recent versions of Python libraries, ensuring greater future compatibility.</li>
-            <li>Modified the "Custom Data Generator" tool to extract rules, reactions, bounds, and medium information from a COBRA model.</li>
-            <li>Developed the "RAS to Bound" tool, which generates metabolic reaction bounds based on the RAS matrix and a growth medium (either custom or one of 26 pre-defined settings), enabling the creation of cell-specific bounds from a generic metabolic model (e.g., ENGRO2 or a custom model).</li>
-            <li>Developed the "Flux Simulation" tool, allowing users to sample multiple metabolic models using cell-specific bounds, employing the CBS and OPTGP algorithms. This tool also supports flux analysis using FBA, pFBA, FVA, and biomass sensitivity analysis.</li>
-            <li>Developed the "Metabolic Flux Enrichment Analysis" tool, which visualizes up-regulated fluxes identified by the "Flux Simulation" tool, compares different sub-classes identified by the clustering tool over fluxomics data, and visualizes all results on the metabolic map.</li>
-        </ul>
-
-        <h3 class="mt-4">Current State and Future Extensions</h3>
-        <p>
-            Currently, the updated MaREA4Galaxy tool allows users to perform constraint-based enrichment analysis of metabolic pathways using RNA-seq profiles by simulating fluxomics. Additionally, users can compare different sub-populations identified by the clustering tool. The architecture minimizes computational costs by handling cell-specific models through a set of bounds, without storing complete COBRA models, which would contain a large amount of redundant information.
-        </p>
-        <p>
-            The implementation of the "Metabolic Flux Enrichment Analysis" tool did not leave enough time to extend the clustering module to new algorithms such as HDBSCAN, Leiden, and Louvain. This is a potential future extension to consider. Moreover, implementing a more advanced clustering grid search could further optimize clustering results.
-        </p>
-
-        <h3 class="mt-4">About the Code</h3>
-        <p>
-            I worked on the Mercurial repository of MaREA4Galaxy, where this document is stored. I committed all my changes, as shown by the repository history, though without using any Git-like merge operations due to the limitations of the Mercurial interface.
-        </p>
-
-        <h3 class="mt-4">Conclusions</h3>
-        <p>
-            Over the past years, I have focused on biology-related subjects, particularly metabolic fluxes and other omics data such as gene expression datasets. Through this project, I was able to apply the knowledge I have gained in constraint-based modeling, flux sampling, and omics enrichment analysis by expanding the MaREA4Galaxy tool. This experience not only enhanced my programming skills but also deepened my understanding of the real needs of biologists when working with such omics data.
-        </p>
-    </div>
-</body>
-</html>
-

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/README.md	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,11 +0,0 @@
-# Official repository for the COBRAxy toolset
-> COBRAxy (COBRApy in Galaxy) is a user-friendly tool that allows a user to user to characterize and to graphically compare simulated fluxomics coming from groups of samples with different transcriptional regulation of metabolism. 
-It extends the MaREA 2 (Metabolic Reaction Enrichment Analysis) tool that enables users to compare groups in terms of RAS and RPS only. The tool is available as plug-in for the widely-used Galaxy platform for comparative genomics and bioinformatics analyses.
-
-## Useful links:
-- COBRAxy Google Summer of Code 2024: https://summerofcode.withgoogle.com/programs/2024/projects/LSrCKfq7
-- COBRApy: https://opencobra.github.io/cobrapy/
-- MaREA4Galaxy: https://galaxyproject.org/use/marea4galaxy/
-- Galaxy project: https://usegalaxy.org/
-
-## Documentation:
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/custom_data_generator.py	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,218 +0,0 @@
-import os
-import csv
-import cobra
-import pickle
-import argparse
-import pandas as pd
-import utils.general_utils as utils
-import utils.rule_parsing  as rulesUtils
-from typing import Optional, Tuple, Union, Dict
-import utils.reaction_parsing as reactionUtils
-
-ARGS : argparse.Namespace
-def process_args() -> argparse.Namespace:
-    """
-    Interfaces the script of a module with its frontend, making the user's choices for
-    various parameters available as values in code.
-
-    Args:
-        args : Always obtained (in file) from sys.argv
-
-    Returns:
-        Namespace : An object containing the parsed arguments
-    """
-    parser = argparse.ArgumentParser(
-        usage = "%(prog)s [options]",
-        description = "generate custom data from a given model")
-    
-    parser.add_argument("-ol", "--out_log", type = str, required = True, help = "Output log")
-
-    parser.add_argument("-orules", "--out_rules", type = str, required = True, help = "Output rules")
-    parser.add_argument("-orxns", "--out_reactions", type = str, required = True, help = "Output reactions")
-    parser.add_argument("-omedium", "--out_medium", type = str, required = True, help = "Output medium")
-    parser.add_argument("-obnds", "--out_bounds", type = str, required = True, help = "Output bounds")
-
-    parser.add_argument("-id", "--input",   type = str, required = True, help = "Input model")
-    parser.add_argument("-mn", "--name",    type = str, required = True, help = "Input model name")
-    # ^ I need this because galaxy converts my files into .dat but I need to know what extension they were in
-    
-    argsNamespace = parser.parse_args()
-    argsNamespace.out_dir = "result"
-    # ^ can't get this one to work from xml, there doesn't seem to be a way to get the directory attribute from the collection
-
-    return argsNamespace
-
-################################- INPUT DATA LOADING -################################
-def load_custom_model(file_path :utils.FilePath, ext :Optional[utils.FileFormat] = None) -> cobra.Model:
-    """
-    Loads a custom model from a file, either in JSON or XML format.
-
-    Args:
-        file_path : The path to the file containing the custom model.
-        ext : explicit file extension. Necessary for standard use in galaxy because of its weird behaviour.
-
-    Raises:
-        DataErr : if the file is in an invalid format or cannot be opened for whatever reason.    
-    
-    Returns:
-        cobra.Model : the model, if successfully opened.
-    """
-    ext = ext if ext else file_path.ext
-    try:
-        if ext is utils.FileFormat.XML:
-            return cobra.io.read_sbml_model(file_path.show())
-        
-        if ext is utils.FileFormat.JSON:
-            return cobra.io.load_json_model(file_path.show())
-
-    except Exception as e: raise utils.DataErr(file_path, e.__str__())
-    raise utils.DataErr(file_path,
-        f"Formato \"{file_path.ext}\" non riconosciuto, sono supportati solo file JSON e XML")
-
-################################- DATA GENERATION -################################
-ReactionId = str
-def generate_rules(model: cobra.Model, *, asParsed = True) -> Union[Dict[ReactionId, rulesUtils.OpList], Dict[ReactionId, str]]:
-    """
-    Generates a dictionary mapping reaction ids to rules from the model.
-
-    Args:
-        model : the model to derive data from.
-        asParsed : if True parses the rules to an optimized runtime format, otherwise leaves them as strings.
-
-    Returns:
-        Dict[ReactionId, rulesUtils.OpList] : the generated dictionary of parsed rules.
-        Dict[ReactionId, str] : the generated dictionary of raw rules.
-    """
-    # Is the below approach convoluted? yes
-    # Ok but is it inefficient? probably
-    # Ok but at least I don't have to repeat the check at every rule (I'm clinically insane)
-    _ruleGetter   =  lambda reaction : reaction.gene_reaction_rule
-    ruleExtractor = (lambda reaction :
-        rulesUtils.parseRuleToNestedList(_ruleGetter(reaction))) if asParsed else _ruleGetter
-
-    return {
-        reaction.id : ruleExtractor(reaction)
-        for reaction in model.reactions
-        if reaction.gene_reaction_rule }
-
-def generate_reactions(model :cobra.Model, *, asParsed = True) -> Dict[ReactionId, str]:
-    """
-    Generates a dictionary mapping reaction ids to reaction formulas from the model.
-
-    Args:
-        model : the model to derive data from.
-        asParsed : if True parses the reactions to an optimized runtime format, otherwise leaves them as they are.
-
-    Returns:
-        Dict[ReactionId, str] : the generated dictionary.
-    """
-
-    unparsedReactions = {
-        reaction.id : reaction.reaction
-        for reaction in model.reactions
-        if reaction.reaction 
-    }
-
-    if not asParsed: return unparsedReactions
-    
-    return reactionUtils.create_reaction_dict(unparsedReactions)
-
-def get_medium(model:cobra.Model) -> pd.DataFrame:
-    trueMedium=[]
-    for r in model.reactions:
-        positiveCoeff=0
-        for m in r.metabolites:
-            if r.get_coefficient(m.id)>0:
-                positiveCoeff=1;
-        if (positiveCoeff==0 and r.lower_bound<0):
-            trueMedium.append(r.id)
-
-    df_medium = pd.DataFrame()
-    df_medium["reaction"] = trueMedium
-    return df_medium
-
-def generate_bounds(model:cobra.Model) -> pd.DataFrame:
-
-    rxns = []
-    for reaction in model.reactions:
-        rxns.append(reaction.id)
-
-    bounds = pd.DataFrame(columns = ["lower_bound", "upper_bound"], index=rxns)
-
-    for reaction in model.reactions:
-        bounds.loc[reaction.id] = [reaction.lower_bound, reaction.upper_bound]
-    return bounds
-
-
-###############################- FILE SAVING -################################
-def save_as_csv_filePath(data :dict, file_path :utils.FilePath, fieldNames :Tuple[str, str]) -> None:
-    """
-    Saves any dictionary-shaped data in a .csv file created at the given file_path as FilePath.
-
-    Args:
-        data : the data to be written to the file.
-        file_path : the path to the .csv file.
-        fieldNames : the names of the fields (columns) in the .csv file.
-    
-    Returns:
-        None
-    """
-    with open(file_path.show(), 'w', newline='') as csvfile:
-        writer = csv.DictWriter(csvfile, fieldnames = fieldNames, dialect="excel-tab")
-        writer.writeheader()
-
-        for key, value in data.items():
-            writer.writerow({ fieldNames[0] : key, fieldNames[1] : value })
-
-def save_as_csv(data :dict, file_path :str, fieldNames :Tuple[str, str]) -> None:
-    """
-    Saves any dictionary-shaped data in a .csv file created at the given file_path as string.
-
-    Args:
-        data : the data to be written to the file.
-        file_path : the path to the .csv file.
-        fieldNames : the names of the fields (columns) in the .csv file.
-    
-    Returns:
-        None
-    """
-    with open(file_path, 'w', newline='') as csvfile:
-        writer = csv.DictWriter(csvfile, fieldnames = fieldNames, dialect="excel-tab")
-        writer.writeheader()
-
-        for key, value in data.items():
-            writer.writerow({ fieldNames[0] : key, fieldNames[1] : value })
-
-###############################- ENTRY POINT -################################
-def main() -> None:
-    """
-    Initializes everything and sets the program in motion based on the fronted input arguments.
-    
-    Returns:
-        None
-    """
-    # get args from frontend (related xml)
-    global ARGS
-    ARGS = process_args()
-
-    # this is the worst thing I've seen so far, congrats to the former MaREA devs for suggesting this!
-    if os.path.isdir(ARGS.out_dir) == False: os.makedirs(ARGS.out_dir)
-
-    # load custom model
-    model = load_custom_model(
-        utils.FilePath.fromStrPath(ARGS.input), utils.FilePath.fromStrPath(ARGS.name).ext)
-
-    # generate data
-    rules = generate_rules(model, asParsed = False)
-    reactions = generate_reactions(model, asParsed = False)
-    bounds = generate_bounds(model)
-    medium = get_medium(model)
-
-    # save files out of collection: path coming from xml
-    save_as_csv(rules, ARGS.out_rules, ("ReactionID", "Rule"))
-    save_as_csv(reactions, ARGS.out_reactions, ("ReactionID", "Reaction"))
-    bounds.to_csv(ARGS.out_bounds, sep = '\t')
-    medium.to_csv(ARGS.out_medium, sep = '\t')
-
-if __name__ == '__main__':
-    main()
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/custom_data_generator.xml	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,63 +0,0 @@
-<tool id="CustomDataGenerator" name="Custom Data Generator" version="2.0.0">
-    
-    <macros>
-        <import>marea_macros.xml</import>
-    </macros>
-
-	<requirements>
-        <requirement type="package" version="1.24.4">numpy</requirement>
-        <requirement type="package" version="2.0.3">pandas</requirement>
-		<requirement type="package" version="0.29.0">cobra</requirement>
-        <requirement type="package" version="5.2.2">lxml</requirement>
-	</requirements>
-
-    <command detect_errors="exit_code">
-        <![CDATA[
-      	python $__tool_directory__/custom_data_generator.py
-        --input $input
-        --name $input.element_identifier
-        --out_log $log
-        --out_rules $rules
-        --out_reactions $reactions
-        --out_bounds $bounds
-        --out_medium $medium
-        ]]>
-    </command>
-    <inputs>
-        <param name="input" argument="--input" type="data" format="xml, json" label="Custom model:" />
-        <param name="name" argument="--name" type="text" label="Model's name:" value="Model" help="Default: Model" />
-    </inputs>
-
-    <outputs>
-        <data format="txt" name="log" label="${tool.name} - Log" />
-        <data format="tabular" name="rules" label="${name}_Rules" />
-        <data format="tabular" name="reactions" label="${name}_Reactions" />
-        <data format="tabular" name="bounds" label="${name}_Bounds" />
-        <data format="tabular" name="medium" label="${name}_Medium" />
-    </outputs>
-
-    <help>
-    <![CDATA[
-What it does
--------------
-
-This tool generates four files containing reactions, rules, reaction bounds and medium composition respectively, starting from a custom model in JSON or XML format.
-Reactions and rules can be used as inputs for the RAS and RPS generator tools.
-
-Accepted files:
-    - A model: JSON or XML file reporting reactions and rules contained in the model.   
-
-
-Output:
--------------
-
-The tool generates:
-    - rules: reporting the rules for each reaction in the custom model given. Format: csv (tab separated).
-    - reactions: reporting the reactions in the custom model given. Format: csv (tab separated).
-    - reaction bounds: reporting the lower and upper bounds of each model reaction. Format: csv (tab separated).
-    - medium composition: reporting the list of exchange/transport reactions. Format: csv (tab separated).
-    - a log file (.txt).
-    ]]>
-    </help>
-    <expand macro="citations" />
-</tool>
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/flux_simulation.py	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,437 +0,0 @@
-import argparse
-import utils.general_utils as utils
-from typing import Optional, List
-import os
-import numpy as np
-import pandas as pd
-import cobra
-import utils.CBS_backend as CBS_backend
-from joblib import Parallel, delayed, cpu_count
-from cobra.sampling import OptGPSampler
-import sys
-
-################################# process args ###############################
-def process_args(args :List[str]) -> argparse.Namespace:
-    """
-    Processes command-line arguments.
-
-    Args:
-        args (list): List of command-line arguments.
-
-    Returns:
-        Namespace: An object containing parsed arguments.
-    """
-    parser = argparse.ArgumentParser(usage = '%(prog)s [options]',
-                                     description = 'process some value\'s')
-
-    parser.add_argument('-ol', '--out_log', 
-                        help = "Output log")
-    
-    parser.add_argument('-td', '--tool_dir',
-                        type = str,
-                        required = True,
-                        help = 'your tool directory')
-    
-    parser.add_argument('-in', '--input',
-                        required = True,
-                        type=str,
-                        help = 'inputs bounds')
-    
-    parser.add_argument('-ni', '--names',
-                        required = True,
-                        type=str,
-                        help = 'cell names')
- 
-    parser.add_argument(
-        '-ms', '--model_selector', 
-        type = utils.Model, default = utils.Model.ENGRO2, choices = [utils.Model.ENGRO2, utils.Model.Custom],
-        help = 'chose which type of model you want use')
-    
-    parser.add_argument("-mo", "--model", type = str)
-    
-    parser.add_argument("-mn", "--model_name", type = str, help = "custom mode name")
-    
-    parser.add_argument('-a', '--algorithm',
-                        type = str,
-                        choices = ['OPTGP', 'CBS'],
-                        required = True,
-                        help = 'choose sampling algorithm')
-    
-    parser.add_argument('-th', '--thinning', 
-                        type = int,
-                        default= 100,
-                        required=False,
-                        help = 'choose thinning')
-    
-    parser.add_argument('-ns', '--n_samples', 
-                        type = int,
-                        required = True,
-                        help = 'choose how many samples')
-    
-    parser.add_argument('-sd', '--seed', 
-                        type = int,
-                        required = True,
-                        help = 'seed')
-    
-    parser.add_argument('-nb', '--n_batches', 
-                        type = int,
-                        required = True,
-                        help = 'choose how many batches')
-    
-    parser.add_argument('-ot', '--output_type', 
-                        type = str,
-                        required = True,
-                        help = 'output type')
-    
-    parser.add_argument('-ota', '--output_type_analysis', 
-                        type = str,
-                        required = False,
-                        help = 'output type analysis')
-    
-    ARGS = parser.parse_args()
-    return ARGS
-
-########################### warning ###########################################
-def warning(s :str) -> None:
-    """
-    Log a warning message to an output log file and print it to the console.
-
-    Args:
-        s (str): The warning message to be logged and printed.
-    
-    Returns:
-      None
-    """
-    with open(ARGS.out_log, 'a') as log:
-        log.write(s + "\n\n")
-    print(s)
-
-
-def write_to_file(dataset: pd.DataFrame, name: str, keep_index:bool=False)->None:
-    dataset.index.name = 'Reactions'
-    dataset.to_csv(ARGS.output_folder + name + ".csv", sep = '\t', index = keep_index)
-
-############################ dataset input ####################################
-def read_dataset(data :str, name :str) -> pd.DataFrame:
-    """
-    Read a dataset from a CSV file and return it as a pandas DataFrame.
-
-    Args:
-        data (str): Path to the CSV file containing the dataset.
-        name (str): Name of the dataset, used in error messages.
-
-    Returns:
-        pandas.DataFrame: DataFrame containing the dataset.
-
-    Raises:
-        pd.errors.EmptyDataError: If the CSV file is empty.
-        sys.exit: If the CSV file has the wrong format, the execution is aborted.
-    """
-    try:
-        dataset = pd.read_csv(data, sep = '\t', header = 0, index_col=0, engine='python')
-    except pd.errors.EmptyDataError:
-        sys.exit('Execution aborted: wrong format of ' + name + '\n')
-    if len(dataset.columns) < 2:
-        sys.exit('Execution aborted: wrong format of ' + name + '\n')
-    return dataset
-
-
-
-def OPTGP_sampler(model:cobra.Model, model_name:str, n_samples:int=1000, thinning:int=100, n_batches:int=1, seed:int=0)-> None:
-    """
-    Samples from the OPTGP (Optimal Global Perturbation) algorithm and saves the results to CSV files.
-
-    Args:
-        model (cobra.Model): The COBRA model to sample from.
-        model_name (str): The name of the model, used in naming output files.
-        n_samples (int, optional): Number of samples per batch. Default is 1000.
-        thinning (int, optional): Thinning parameter for the sampler. Default is 100.
-        n_batches (int, optional): Number of batches to run. Default is 1.
-        seed (int, optional): Random seed for reproducibility. Default is 0.
-    
-    Returns:
-        None
-    """
-
-    for i in range(0, n_batches):
-        optgp = OptGPSampler(model, thinning, seed)
-        samples = optgp.sample(n_samples)
-        samples.to_csv(ARGS.output_folder +  model_name + '_'+ str(i)+'_OPTGP.csv', index=False)
-        seed+=1
-    samplesTotal = pd.DataFrame()
-    for i in range(0, n_batches):
-        samples_batch = pd.read_csv(ARGS.output_folder  +  model_name + '_'+ str(i)+'_OPTGP.csv')
-        samplesTotal = pd.concat([samplesTotal, samples_batch], ignore_index = True)
-
-    write_to_file(samplesTotal.T, model_name, True)
-
-    for i in range(0, n_batches):
-        os.remove(ARGS.output_folder +   model_name + '_'+ str(i)+'_OPTGP.csv')
-    pass
-
-
-def CBS_sampler(model:cobra.Model, model_name:str, n_samples:int=1000, n_batches:int=1, seed:int=0)-> None:
-    """
-    Samples using the CBS (Constraint-based Sampling) algorithm and saves the results to CSV files.
-
-    Args:
-        model (cobra.Model): The COBRA model to sample from.
-        model_name (str): The name of the model, used in naming output files.
-        n_samples (int, optional): Number of samples per batch. Default is 1000.
-        n_batches (int, optional): Number of batches to run. Default is 1.
-        seed (int, optional): Random seed for reproducibility. Default is 0.
-    
-    Returns:
-        None
-    """
-
-    df_FVA = cobra.flux_analysis.flux_variability_analysis(model,fraction_of_optimum=0).round(6)
-    
-    df_coefficients = CBS_backend.randomObjectiveFunction(model, n_samples*n_batches, df_FVA, seed=seed)
-
-    for i in range(0, n_batches):
-        samples = pd.DataFrame(columns =[reaction.id for reaction in model.reactions], index = range(n_samples))
-        try:
-            CBS_backend.randomObjectiveFunctionSampling(model, n_samples, df_coefficients.iloc[:,i*n_samples:(i+1)*n_samples], samples)
-        except Exception as e:
-            utils.logWarning(
-            "Warning: GLPK solver has failed for " + model_name + ". Trying with COBRA interface. Error:" + str(e),
-            ARGS.out_log)
-            CBS_backend.randomObjectiveFunctionSampling_cobrapy(model, n_samples, df_coefficients.iloc[:,i*n_samples:(i+1)*n_samples], 
-                                                    samples)
-        utils.logWarning(ARGS.output_folder +  model_name + '_'+ str(i)+'_CBS.csv', ARGS.out_log)
-        samples.to_csv(ARGS.output_folder +  model_name + '_'+ str(i)+'_CBS.csv', index=False)
-
-    samplesTotal = pd.DataFrame()
-    for i in range(0, n_batches):
-        samples_batch = pd.read_csv(ARGS.output_folder  +  model_name + '_'+ str(i)+'_CBS.csv')
-        samplesTotal = pd.concat([samplesTotal, samples_batch], ignore_index = True)
-
-    write_to_file(samplesTotal.T, model_name, True)
-
-    for i in range(0, n_batches):
-        os.remove(ARGS.output_folder +   model_name + '_'+ str(i)+'_CBS.csv')
-    pass
-
-
-def model_sampler(model_input_original:cobra.Model, bounds_path:str, cell_name:str)-> List[pd.DataFrame]:
-    """
-    Prepares the model with bounds from the dataset and performs sampling and analysis based on the selected algorithm.
-
-    Args:
-        model_input_original (cobra.Model): The original COBRA model.
-        bounds_path (str): Path to the CSV file containing the bounds dataset.
-        cell_name (str): Name of the cell, used to generate filenames for output.
-
-    Returns:
-        List[pd.DataFrame]: A list of DataFrames containing statistics and analysis results.
-    """
-
-    model_input = model_input_original.copy()
-    bounds_df = read_dataset(bounds_path, "bounds dataset")
-    for rxn_index, row in bounds_df.iterrows():
-        model_input.reactions.get_by_id(rxn_index).lower_bound = row.lower_bound
-        model_input.reactions.get_by_id(rxn_index).upper_bound = row.upper_bound
-    
-    name = cell_name.split('.')[0]
-    
-    if ARGS.algorithm == 'OPTGP':
-        OPTGP_sampler(model_input, name, ARGS.n_samples, ARGS.thinning, ARGS.n_batches, ARGS.seed)
-
-    elif ARGS.algorithm == 'CBS':
-        CBS_sampler(model_input,  name, ARGS.n_samples, ARGS.n_batches, ARGS.seed)
-
-    df_mean, df_median, df_quantiles = fluxes_statistics(name, ARGS.output_types)
-
-    if("fluxes" not in ARGS.output_types):
-        os.remove(ARGS.output_folder  +  name + '.csv')
-
-    returnList = []
-    returnList.append(df_mean)
-    returnList.append(df_median)
-    returnList.append(df_quantiles)
-
-    df_pFBA, df_FVA, df_sensitivity = fluxes_analysis(model_input, name, ARGS.output_type_analysis)
-
-    if("pFBA" in ARGS.output_type_analysis):
-        returnList.append(df_pFBA)
-    if("FVA" in ARGS.output_type_analysis):
-        returnList.append(df_FVA)
-    if("sensitivity" in ARGS.output_type_analysis):
-        returnList.append(df_sensitivity)
-
-    return returnList
-
-def fluxes_statistics(model_name: str,  output_types:List)-> List[pd.DataFrame]:
-    """
-    Computes statistics (mean, median, quantiles) for the fluxes.
-
-    Args:
-        model_name (str): Name of the model, used in filename for input.
-        output_types (List[str]): Types of statistics to compute (mean, median, quantiles).
-
-    Returns:
-        List[pd.DataFrame]: List of DataFrames containing mean, median, and quantiles statistics.
-    """
-
-    df_mean = pd.DataFrame()
-    df_median= pd.DataFrame()
-    df_quantiles= pd.DataFrame()
-
-    df_samples = pd.read_csv(ARGS.output_folder  +  model_name + '.csv', sep = '\t', index_col = 0).T
-    df_samples = df_samples.round(8)
-
-    for output_type in output_types:
-        if(output_type == "mean"):
-            df_mean = df_samples.mean()
-            df_mean = df_mean.to_frame().T
-            df_mean = df_mean.reset_index(drop=True)
-            df_mean.index = [model_name]
-        elif(output_type == "median"):
-            df_median = df_samples.median()
-            df_median = df_median.to_frame().T
-            df_median = df_median.reset_index(drop=True)
-            df_median.index = [model_name]
-        elif(output_type == "quantiles"):
-            newRow = []
-            cols = []
-            for rxn in df_samples.columns:
-                quantiles = df_samples[rxn].quantile([0.25, 0.50, 0.75])
-                newRow.append(quantiles[0.25])
-                cols.append(rxn + "_q1")
-                newRow.append(quantiles[0.5])
-                cols.append(rxn + "_q2")
-                newRow.append(quantiles[0.75])
-                cols.append(rxn + "_q3")
-            df_quantiles = pd.DataFrame(columns=cols)
-            df_quantiles.loc[0] = newRow
-            df_quantiles = df_quantiles.reset_index(drop=True)
-            df_quantiles.index = [model_name]
-    
-    return df_mean, df_median, df_quantiles
-
-def fluxes_analysis(model:cobra.Model,  model_name:str, output_types:List)-> List[pd.DataFrame]:
-    """
-    Performs flux analysis including pFBA, FVA, and sensitivity analysis.
-
-    Args:
-        model (cobra.Model): The COBRA model to analyze.
-        model_name (str): Name of the model, used in filenames for output.
-        output_types (List[str]): Types of analysis to perform (pFBA, FVA, sensitivity).
-
-    Returns:
-        List[pd.DataFrame]: List of DataFrames containing pFBA, FVA, and sensitivity analysis results.
-    """
-
-    df_pFBA = pd.DataFrame()
-    df_FVA= pd.DataFrame()
-    df_sensitivity= pd.DataFrame()
-
-    for output_type in output_types:
-        if(output_type == "pFBA"):
-            model.objective = "Biomass"
-            solution = cobra.flux_analysis.pfba(model)
-            fluxes = solution.fluxes
-            df_pFBA.loc[0,[rxn._id for rxn in model.reactions]] = fluxes.tolist()
-            df_pFBA = df_pFBA.reset_index(drop=True)
-            df_pFBA.index = [model_name]
-            df_pFBA = df_pFBA.astype(float).round(6)
-        elif(output_type == "FVA"):
-            fva = cobra.flux_analysis.flux_variability_analysis(model, fraction_of_optimum=0, processes=1).round(8)
-            columns = []
-            for rxn in fva.index.to_list():
-                columns.append(rxn + "_min")
-                columns.append(rxn + "_max")
-            df_FVA= pd.DataFrame(columns = columns)
-            for index_rxn, row in fva.iterrows():
-                df_FVA.loc[0, index_rxn+ "_min"] = fva.loc[index_rxn, "minimum"]
-                df_FVA.loc[0, index_rxn+ "_max"] = fva.loc[index_rxn, "maximum"]
-            df_FVA = df_FVA.reset_index(drop=True)
-            df_FVA.index = [model_name]
-            df_FVA = df_FVA.astype(float).round(6)
-        elif(output_type == "sensitivity"):
-            model.objective = "Biomass"
-            solution_original = model.optimize().objective_value
-            reactions = model.reactions
-            single = cobra.flux_analysis.single_reaction_deletion(model)
-            newRow = []
-            df_sensitivity = pd.DataFrame(columns = [rxn.id for rxn in reactions], index = [model_name])
-            for rxn in reactions:
-                newRow.append(single.knockout[rxn.id].growth.values[0]/solution_original)
-            df_sensitivity.loc[model_name] = newRow
-            df_sensitivity = df_sensitivity.astype(float).round(6)
-    return df_pFBA, df_FVA, df_sensitivity
-
-############################# main ###########################################
-def main() -> None:
-    """
-    Initializes everything and sets the program in motion based on the fronted input arguments.
-
-    Returns:
-        None
-    """
-    if not os.path.exists('flux_simulation/'):
-        os.makedirs('flux_simulation/')
-
-    num_processors = cpu_count()
-
-    global ARGS
-    ARGS = process_args(sys.argv)
-
-    ARGS.output_folder = 'flux_simulation/'
-    
-    
-    model_type :utils.Model = ARGS.model_selector
-    if model_type is utils.Model.Custom:
-        model = model_type.getCOBRAmodel(customPath = utils.FilePath.fromStrPath(ARGS.model), customExtension = utils.FilePath.fromStrPath(ARGS.model_name).ext)
-    else:
-        model = model_type.getCOBRAmodel(toolDir=ARGS.tool_dir)
-    
-    ARGS.bounds = ARGS.input.split(",")
-    ARGS.bounds_name = ARGS.names.split(",")
-    ARGS.output_types = ARGS.output_type.split(",")
-    ARGS.output_type_analysis = ARGS.output_type_analysis.split(",")
-
-
-    results = Parallel(n_jobs=num_processors)(delayed(model_sampler)(model, bounds_path, cell_name) for bounds_path, cell_name in zip(ARGS.bounds, ARGS.bounds_name))
-
-    all_mean = pd.concat([result[0] for result in results], ignore_index=False)
-    all_median = pd.concat([result[1] for result in results], ignore_index=False)
-    all_quantiles = pd.concat([result[2] for result in results], ignore_index=False)
-
-    if("mean" in ARGS.output_types):
-        all_mean = all_mean.fillna(0.0)
-        all_mean = all_mean.sort_index()
-        write_to_file(all_mean.T, "mean", True)
-
-    if("median" in ARGS.output_types):
-        all_median = all_median.fillna(0.0)
-        all_median = all_median.sort_index()
-        write_to_file(all_median.T, "median", True)
-    
-    if("quantiles" in ARGS.output_types):
-        all_quantiles = all_quantiles.fillna(0.0)
-        all_quantiles = all_quantiles.sort_index()
-        write_to_file(all_quantiles.T, "quantiles", True)
-
-    index_result = 3
-    if("pFBA" in ARGS.output_type_analysis):
-        all_pFBA = pd.concat([result[index_result] for result in results], ignore_index=False)
-        all_pFBA = all_pFBA.sort_index()
-        write_to_file(all_pFBA.T, "pFBA", True)
-        index_result+=1
-    if("FVA" in ARGS.output_type_analysis):
-        all_FVA= pd.concat([result[index_result] for result in results], ignore_index=False)
-        all_FVA = all_FVA.sort_index()
-        write_to_file(all_FVA.T, "FVA", True)
-        index_result+=1
-    if("sensitivity" in ARGS.output_type_analysis):
-        all_sensitivity = pd.concat([result[index_result] for result in results], ignore_index=False)
-        all_sensitivity = all_sensitivity.sort_index()
-        write_to_file(all_sensitivity.T, "sensitivity", True)
-
-    pass
-        
-##############################################################################
-if __name__ == "__main__":
-    main()
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/flux_simulation.xml	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,134 +0,0 @@
-<tool id="fluxSimulation" name="Flux Simulation" version="2.0.0">
-    
-    <macros>
-        <import>marea_macros.xml</import>
-    </macros>
-
-	<requirements>
-        <requirement type="package" version="1.24.4">numpy</requirement>
-        <requirement type="package" version="2.0.3">pandas</requirement>
-		<requirement type="package" version="0.29.0">cobra</requirement>
-        <requirement type="package" version="5.2.2">lxml</requirement>
-        <requirement type="package" version="1.4.2">joblib</requirement>
-        <requirement type="package" version="1.10.1">scipy</requirement>
-	</requirements>
-
-    <command detect_errors="exit_code">
-        <![CDATA[
-        python $__tool_directory__/flux_simulation.py
-        --tool_dir $__tool_directory__
-        --model_selector $cond_model.model_selector
-        #if $cond_model.model_selector == 'Custom'
-            --model $model
-            --model_name $model.element_identifier
-        #end if
-        --input "${",".join(map(str, $inputs))}"
-        #set $names = ""
-        #for $input_temp in $inputs:
-            #set $names = $names + $input_temp.element_identifier + ","
-        #end for
-        --name $names
-        --thinning 0
-        #if $algorithm_param.algorithm == 'OPTGP':
-        	--thinning $algorithm_param.thinning
-        #end if
-        --algorithm $algorithm_param.algorithm
-        --n_batches $n_batches
-        --n_samples $n_samples
-        --seed $seed
-        --output_type "${",".join(map(str, $output_types))}"
-        --output_type_analysis "${",".join(map(str, $output_types_analysis))}"
-        --out_log $log
-        ]]>
-    </command>
-    <inputs>
-
-        <conditional name="cond_model">
-            <expand macro="options_ras_to_bounds_model"/>
-            <when value="Custom">
-                <param name="model" argument="--model" type="data" format="json, xml" label="Custom model" />
-            </when>
-        </conditional> 
-
-        <param name="inputs" argument="--inputs" multiple="true" type="data" format="tabular, csv, tsv" label="Bound(s):" />
-        
-        
-        <conditional name="algorithm_param">
-			<param name="algorithm" argument="--algorithm" type="select" label="Choose sampling algorithm:">
-                    <option value="CBS" selected="true">CBS</option>
-                	<option value="OPTGP">OPTGP</option>
-        	</param>
-        	<when value="OPTGP">
-        		<param name="thinning" argument="--thinning" type="integer" label="Thinning:"  value="100" help="Number of iterations to wait before taking a sample."/>
-        	</when>
-
-		</conditional>
-
-
-        <param name="n_samples" argument="--n_samples" type="integer" label="Samples:" value="1000"/>
-
-        <param name="n_batches" argument="--n_batches" type="integer" label="Batches:" value="10" help="This is useful for computational perfomances."/>
-
-        <param name="seed" argument="--seed" type="integer" label="Seed:" value="0" helph="Random seed."/>
-
-        <param type="select" argument="--output_types" multiple="true" name="output_types" label="Desired outputs from sampling">
-            <option value="mean" selected="true">Mean</option>
-            <option value="median" selected="true">Median</option>
-            <option value="quantiles" selected="true">Quantiles</option>
-            <option value="fluxes" selected="false">All fluxes</option>
-        </param>
-
-        <param type="select" argument="--output_types_analysis" multiple="true" name="output_types_analysis" label="Desired outputs from flux analysis">
-            <option value="pFBA" selected="false">pFBA</option>
-            <option value="FVA" selected="false">FVA</option>
-            <option value="sensitivity" selected="false">Sensitivity reaction knock-out (Biomass)</option>
-        </param>
-    </inputs>
-
-        		
-    <outputs>
-        <data format="txt" name="log" label="Flux Simulation - Log" />
-
-        <data name="output" format="tabular" label="Flux Simulation - Output">
-            <discover_datasets pattern="__name_and_ext__"
-                directory="flux_simulation" visible="true" />
-        </data>
-
-    </outputs>
-
-    <help>
-    <![CDATA[
-What it does
--------------
-
-This tool generates flux samples starting from a model in JSON or XML format by using CBS (Corner-based sampling) or OPTGP (Improved Artificial Centering Hit-and-Run sampler) sampling algorithms.
-
-It can return sampled fluxes by appliying summary statistics: 
-   - mean
-   - median
-   - quantiles (0.25, 0.50, 0.75). 
-
-Flux analysis can be perfomed over the metabolic model:
-   - parsimoniuos-FBA (optimized by Biomass)
-   - FVA
-   - Biomass sensitivity analysis (single reaction knock-out). It is the ratio between the optimal of the Biomass reaction computed by FBA after knocking-out a reaction and the same over the complete model.
-
-Accepted files:
-   - A model: JSON or XML file reporting reactions and rules contained in the model. It can be ENGRO2 or a custom model. 
-   - Context-specific bounds: generated by RAS to Bounds tool. This can be a collection of bounds too (one bounds file per context).
-
-Output:
--------------
-
-The tool generates:
-   - Samples: reporting the sampled fluxes for each reaction (reaction names on the rows and sample names on the columns). Format: tab-separated.
-   - a log file (.txt).
-
-**TIP**: The Batches parameter is useful to mantain in memory just a batch of samples at time. For example, if you wish to sample 10.000 points, than it is suggested to select n_samples = 1.000 and n_batches=10.
-**TIP**: The Thinning parameter of the OPTGP algorithm is useful to converge to a stationary distribution (see cited articles by Galuzzi, Milazzo and Damiani).
-
-]]>
-    </help>
-    <expand macro="citations_fluxes" />
- 
-</tool>
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/flux_to_map.py	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,1055 +0,0 @@
-from __future__ import division
-import csv
-from enum import Enum
-import re
-import sys
-import numpy as np
-import pandas as pd
-import itertools as it
-import scipy.stats as st
-import lxml.etree as ET
-import math
-import utils.general_utils as utils
-from PIL import Image
-import os
-import copy
-import argparse
-import pyvips
-from PIL import Image, ImageDraw, ImageFont
-from typing import Tuple, Union, Optional, List, Dict
-import matplotlib.pyplot as plt
-
-ERRORS = []
-########################## argparse ##########################################
-ARGS :argparse.Namespace
-def process_args() -> argparse.Namespace:
-    """
-    Interfaces the script of a module with its frontend, making the user's choices for various parameters available as values in code.
-
-    Args:
-        args : Always obtained (in file) from sys.argv
-
-    Returns:
-        Namespace : An object containing the parsed arguments
-    """
-    parser = argparse.ArgumentParser(
-        usage = "%(prog)s [options]",
-        description = "process some value's genes to create a comparison's map.")
-    
-    #General:
-    parser.add_argument(
-        '-td', '--tool_dir',
-        type = str,
-        required = True,
-        help = 'your tool directory')
-    
-    parser.add_argument('-on', '--control', type = str)
-    parser.add_argument('-ol', '--out_log', help = "Output log")
-
-    #Computation details:
-    parser.add_argument(
-        '-co', '--comparison',
-        type = str, 
-        default = '1vs1',
-        choices = ['manyvsmany', 'onevsrest', 'onevsmany'])
-    
-    parser.add_argument(
-        '-pv' ,'--pValue',
-        type = float, 
-        default = 0.1, 
-        help = 'P-Value threshold (default: %(default)s)')
-    
-    parser.add_argument(
-        '-fc', '--fChange',
-        type = float, 
-        default = 1.5, 
-        help = 'Fold-Change threshold (default: %(default)s)')
-    
-
-    parser.add_argument(
-        '-op', '--option',
-        type = str, 
-        choices = ['datasets', 'dataset_class'],
-        help='dataset or dataset and class')
-
-    parser.add_argument(
-        '-idf', '--input_data_fluxes',
-        type = str,
-        help = 'input dataset fluxes')
-    
-    parser.add_argument(
-        '-icf', '--input_class_fluxes', 
-        type = str,
-        help = 'sample group specification fluxes')
-    
-    parser.add_argument(
-        '-idsf', '--input_datas_fluxes', 
-        type = str,
-        nargs = '+', 
-        help = 'input datasets fluxes')
-    
-    parser.add_argument(
-        '-naf', '--names_fluxes', 
-        type = str,
-        nargs = '+', 
-        help = 'input names fluxes')
-    
-    #Output:
-    parser.add_argument(
-        "-gs", "--generate_svg",
-        type = utils.Bool("generate_svg"), default = True,
-        help = "choose whether to generate svg")
-    
-    parser.add_argument(
-        "-gp", "--generate_pdf",
-        type = utils.Bool("generate_pdf"), default = True,
-        help = "choose whether to generate pdf")
-    
-    parser.add_argument(
-        '-cm', '--custom_map',
-        type = str,
-        help='custom map to use')
-    
-    parser.add_argument(
-        '-mc',  '--choice_map',
-        type = utils.Model, default = utils.Model.HMRcore,
-        choices = [utils.Model.HMRcore, utils.Model.ENGRO2, utils.Model.Custom])
-    
-    parser.add_argument(
-        '-colorm',  '--color_map',
-        type = str,
-        choices = ["jet", "viridis"])
-
-    args :argparse.Namespace = parser.parse_args()
-    args.net = True
-
-    return args
-          
-############################ dataset input ####################################
-def read_dataset(data :str, name :str) -> pd.DataFrame:
-    """
-    Tries to read the dataset from its path (data) as a tsv and turns it into a DataFrame.
-
-    Args:
-        data : filepath of a dataset (from frontend input params or literals upon calling)
-        name : name associated with the dataset (from frontend input params or literals upon calling)
-
-    Returns:
-        pd.DataFrame : dataset in a runtime operable shape
-    
-    Raises:
-        sys.exit : if there's no data (pd.errors.EmptyDataError) or if the dataset has less than 2 columns
-    """
-    try:
-        dataset = pd.read_csv(data, sep = '\t', header = 0, engine='python')
-    except pd.errors.EmptyDataError:
-        sys.exit('Execution aborted: wrong format of ' + name + '\n')
-    if len(dataset.columns) < 2:
-        sys.exit('Execution aborted: wrong format of ' + name + '\n')
-    return dataset
-
-############################ dataset name #####################################
-def name_dataset(name_data :str, count :int) -> str:
-    """
-    Produces a unique name for a dataset based on what was provided by the user. The default name for any dataset is "Dataset", thus if the user didn't change it this function appends f"_{count}" to make it unique.
-
-    Args:
-        name_data : name associated with the dataset (from frontend input params)
-        count : counter from 1 to make these names unique (external)
-
-    Returns:
-        str : the name made unique
-    """
-    if str(name_data) == 'Dataset':
-        return str(name_data) + '_' + str(count)
-    else:
-        return str(name_data)
-
-############################ map_methods ######################################
-FoldChange = Union[float, int, str] # Union[float, Literal[0, "-INF", "INF"]]
-def fold_change(avg1 :float, avg2 :float) -> FoldChange:
-    """
-    Calculates the fold change between two gene expression values.
-
-    Args:
-        avg1 : average expression value from one dataset avg2 : average expression value from the other dataset
-
-    Returns:
-        FoldChange :
-            0 : when both input values are 0
-            "-INF" : when avg1 is 0
-            "INF" : when avg2 is 0
-            float : for any other combination of values
-    """
-    if avg1 == 0 and avg2 == 0:
-        return 0
-    elif avg1 == 0:
-        return '-INF'
-    elif avg2 == 0:
-        return 'INF'
-    else: # (threshold_F_C - 1) / (abs(threshold_F_C) + 1) con threshold_F_C > 1
-        return (avg1 - avg2) / (abs(avg1) + abs(avg2))
-    
-def fix_style(l :str, col :Optional[str], width :str, dash :str) -> str:
-    """
-    Produces a "fixed" style string to assign to a reaction arrow in the SVG map, assigning style properties to the corresponding values passed as input params.
-
-    Args:
-        l : current style string of an SVG element
-        col : new value for the "stroke" style property
-        width : new value for the "stroke-width" style property
-        dash : new value for the "stroke-dasharray" style property
-
-    Returns:
-        str : the fixed style string
-    """
-    tmp = l.split(';')
-    flag_col = False
-    flag_width = False
-    flag_dash = False
-    for i in range(len(tmp)):
-        if tmp[i].startswith('stroke:'):
-            tmp[i] = 'stroke:' + col
-            flag_col = True
-        if tmp[i].startswith('stroke-width:'):
-            tmp[i] = 'stroke-width:' + width
-            flag_width = True
-        if tmp[i].startswith('stroke-dasharray:'):
-            tmp[i] = 'stroke-dasharray:' + dash
-            flag_dash = True
-    if not flag_col:
-        tmp.append('stroke:' + col)
-    if not flag_width:
-        tmp.append('stroke-width:' + width)
-    if not flag_dash:
-        tmp.append('stroke-dasharray:' + dash)
-    return ';'.join(tmp)
-
-# The type of d values is collapsed, losing precision, because the dict containst lists instead of tuples, please fix!
-def fix_map(d :Dict[str, List[Union[float, FoldChange]]], core_map :ET.ElementTree, threshold_P_V :float, threshold_F_C :float, max_z_score :float) -> ET.ElementTree:
-    """
-    Edits the selected SVG map based on the p-value and fold change data (d) and some significance thresholds also passed as inputs.
-
-    Args:
-        d : dictionary mapping a p-value and a fold-change value (values) to each reaction ID as encoded in the SVG map (keys)
-        core_map : SVG map to modify
-        threshold_P_V : threshold for a p-value to be considered significant
-        threshold_F_C : threshold for a fold change value to be considered significant
-        max_z_score : highest z-score (absolute value)
-    
-    Returns:
-        ET.ElementTree : the modified core_map
-
-    Side effects:
-        core_map : mut
-    """
-    maxT = 12
-    minT = 2
-    grey = '#BEBEBE'
-    blue = '#6495ed'
-    red = '#ecac68'
-    for el in core_map.iter():
-        el_id = str(el.get('id'))
-        if el_id.startswith('R_'):
-            tmp = d.get(el_id[2:])
-            if tmp != None:
-                p_val :float = tmp[0]
-                f_c = tmp[1]
-                z_score = tmp[2]
-                if p_val < threshold_P_V:
-                    if not isinstance(f_c, str):
-                        if abs(f_c) < ((threshold_F_C - 1) / (abs(threshold_F_C) + 1)): # 
-                            col = grey
-                            width = str(minT)
-                        else:
-                            if f_c < 0:
-                                col = blue
-                            elif f_c > 0:
-                                col = red
-                            width = str(max((abs(z_score) * maxT) / max_z_score, minT))
-                    else:
-                        if f_c == '-INF':
-                            col = blue
-                        elif f_c == 'INF':
-                            col = red
-                        width = str(maxT)
-                    dash = 'none'
-                else:
-                    dash = '5,5'
-                    col = grey
-                    width = str(minT)
-                el.set('style', fix_style(el.get('style', ""), col, width, dash))
-    return core_map
-
-def getElementById(reactionId :str, metabMap :ET.ElementTree) -> utils.Result[ET.Element, utils.Result.ResultErr]:
-    """
-    Finds any element in the given map with the given ID. ID uniqueness in an svg file is recommended but
-    not enforced, if more than one element with the exact ID is found only the first will be returned.
-
-    Args:
-        reactionId (str): exact ID of the requested element.
-        metabMap (ET.ElementTree): metabolic map containing the element.
-
-    Returns:
-        utils.Result[ET.Element, ResultErr]: result of the search, either the first match found or a ResultErr.
-    """
-    return utils.Result.Ok(
-        f"//*[@id=\"{reactionId}\"]").map(
-        lambda xPath : metabMap.xpath(xPath)[0]).mapErr(
-        lambda _ : utils.Result.ResultErr(f"No elements with ID \"{reactionId}\" found in map"))
-        # ^^^ we shamelessly ignore the contents of the IndexError, it offers nothing to the user.
-
-def styleMapElement(element :ET.Element, styleStr :str) -> None:
-    currentStyles :str = element.get("style", "")
-    if re.search(r";stroke:[^;]+;stroke-width:[^;]+;stroke-dasharray:[^;]+$", currentStyles):
-        currentStyles = ';'.join(currentStyles.split(';')[:-3])
-
-    element.set("style", currentStyles + styleStr)
-
-class ReactionDirection(Enum):
-    Unknown = ""
-    Direct  = "_F"
-    Inverse = "_B"
-
-    @classmethod
-    def fromDir(cls, s :str) -> "ReactionDirection":
-        # vvv as long as there's so few variants I actually condone the if spam:
-        if s == ReactionDirection.Direct.value:  return ReactionDirection.Direct
-        if s == ReactionDirection.Inverse.value: return ReactionDirection.Inverse
-        return ReactionDirection.Unknown
-
-    @classmethod
-    def fromReactionId(cls, reactionId :str) -> "ReactionDirection":
-        return ReactionDirection.fromDir(reactionId[-2:])
-
-def getArrowBodyElementId(reactionId :str) -> str:
-    if reactionId.endswith("_RV"): reactionId = reactionId[:-3] #TODO: standardize _RV
-    elif ReactionDirection.fromReactionId(reactionId) is not ReactionDirection.Unknown: reactionId = reactionId[:-2]
-    return f"R_{reactionId}"
-
-def getArrowHeadElementId(reactionId :str) -> Tuple[str, str]:
-    """
-    We attempt extracting the direction information from the provided reaction ID, if unsuccessful we provide the IDs of both directions.
-
-    Args:
-        reactionId : the provided reaction ID.
-
-    Returns:
-        Tuple[str, str]: either a single str ID for the correct arrow head followed by an empty string or both options to try.
-    """
-    if reactionId.endswith("_RV"): reactionId = reactionId[:-3] #TODO: standardize _RV
-    elif ReactionDirection.fromReactionId(reactionId) is not ReactionDirection.Unknown: return reactionId[:-3:-1] + reactionId[:-2], ""
-    return f"F_{reactionId}", f"B_{reactionId}"
-
-class ArrowColor(Enum):
-    """
-    Encodes possible arrow colors based on their meaning in the enrichment process.
-    """
-    Invalid       = "#BEBEBE" # gray, fold-change under treshold
-    Transparent   = "#ffffff00" # white, not significant p-value
-    UpRegulated   = "#ecac68" # red, up-regulated reaction
-    DownRegulated = "#6495ed" # blue, down-regulated reaction
-
-    UpRegulatedInv = "#FF0000"
-    # ^^^ different shade of red (actually orange), up-regulated net value for a reversible reaction with
-    # conflicting enrichment in the two directions.
-
-    DownRegulatedInv = "#0000FF"
-    # ^^^ different shade of blue (actually purple), down-regulated net value for a reversible reaction with
-    # conflicting enrichment in the two directions.
-
-    @classmethod
-    def fromFoldChangeSign(cls, foldChange :float, *, useAltColor = False) -> "ArrowColor":
-        colors = (cls.DownRegulated, cls.DownRegulatedInv) if foldChange < 0 else (cls.UpRegulated, cls.UpRegulatedInv)
-        return colors[useAltColor]
-
-    def __str__(self) -> str: return self.value
-
-class Arrow:
-    """
-    Models the properties of a reaction arrow that change based on enrichment.
-    """
-    MIN_W = 2
-    MAX_W = 12
-
-    def __init__(self, width :int, col: ArrowColor, *, isDashed = False) -> None:
-        """
-        (Private) Initializes an instance of Arrow.
-
-        Args:
-            width : width of the arrow, ideally to be kept within Arrow.MIN_W and Arrow.MAX_W (not enforced).
-            col : color of the arrow.
-            isDashed : whether the arrow should be dashed, meaning the associated pValue resulted not significant.
-        
-        Returns:
-            None : practically, a Arrow instance.
-        """
-        self.w    = width
-        self.col  = col
-        self.dash = isDashed
-    
-    def applyTo(self, reactionId :str, metabMap :ET.ElementTree, styleStr :str) -> None:
-        if getElementById(reactionId, metabMap).map(lambda el : styleMapElement(el, styleStr)).isErr:
-            ERRORS.append(reactionId)
-
-    def styleReactionElements(self, metabMap :ET.ElementTree, reactionId :str, *, mindReactionDir = True) -> None:
-        if not mindReactionDir:
-            return self.applyTo(getArrowBodyElementId(reactionId), metabMap, self.toStyleStr())
-        
-        # Now we style the arrow head(s):
-        idOpt1, idOpt2 = getArrowHeadElementId(reactionId)
-        self.applyTo(idOpt1, metabMap, self.toStyleStr(downSizedForTips = True))
-        if idOpt2: self.applyTo(idOpt2, metabMap, self.toStyleStr(downSizedForTips = True))
-
-    def styleReactionElementsMeanMedian(self, metabMap :ET.ElementTree, reactionId :str, isNegative:bool) -> None:
-
-        self.applyTo(getArrowBodyElementId(reactionId), metabMap, self.toStyleStr())
-        idOpt1, idOpt2 = getArrowHeadElementId(reactionId)
-
-        if(isNegative):
-            self.applyTo(idOpt2, metabMap, self.toStyleStr(downSizedForTips = True))
-            self.col = ArrowColor.Transparent
-            self.applyTo(idOpt1, metabMap, self.toStyleStr(downSizedForTips = True)) #trasp
-        else:
-            self.applyTo(idOpt1, metabMap, self.toStyleStr(downSizedForTips = True))
-            self.col = ArrowColor.Transparent
-            self.applyTo(idOpt2, metabMap, self.toStyleStr(downSizedForTips = True)) #trasp
-
-
-    
-    def getMapReactionId(self, reactionId :str, mindReactionDir :bool) -> str:
-        """
-        Computes the reaction ID as encoded in the map for a given reaction ID from the dataset.
-
-        Args:
-            reactionId: the reaction ID, as encoded in the dataset.
-            mindReactionDir: if True forward (F_) and backward (B_) directions will be encoded in the result.
-    
-        Returns:
-            str : the ID of an arrow's body or tips in the map.
-        """
-        # we assume the reactionIds also don't encode reaction dir if they don't mind it when styling the map.
-        if not mindReactionDir: return "R_" + reactionId
-
-        #TODO: this is clearly something we need to make consistent in fluxes
-        return (reactionId[:-3:-1] + reactionId[:-2]) if reactionId[:-2] in ["_F", "_B"] else f"F_{reactionId}" # "Pyr_F" --> "F_Pyr"
-
-    def toStyleStr(self, *, downSizedForTips = False) -> str:
-        """
-        Collapses the styles of this Arrow into a str, ready to be applied as part of the "style" property on an svg element.
-
-        Returns:
-            str : the styles string.
-        """
-        width = self.w
-        if downSizedForTips: width *= 0.8
-        return f";stroke:{self.col};stroke-width:{width};stroke-dasharray:{'5,5' if self.dash else 'none'}"
-
-# vvv These constants could be inside the class itself a static properties, but python
-# was built by brainless organisms so here we are!
-INVALID_ARROW = Arrow(Arrow.MIN_W, ArrowColor.Invalid)
-INSIGNIFICANT_ARROW = Arrow(Arrow.MIN_W, ArrowColor.Invalid, isDashed = True)
-
-def applyFluxesEnrichmentToMap(fluxesEnrichmentRes :Dict[str, Union[Tuple[float, FoldChange], Tuple[float, FoldChange, float, float]]], metabMap :ET.ElementTree, maxNumericZScore :float) -> None:
-    """
-    Applies fluxes enrichment results to the provided metabolic map.
-
-    Args:
-        fluxesEnrichmentRes : fluxes enrichment results.
-        metabMap : the metabolic map to edit.
-        maxNumericZScore : biggest finite z-score value found.
-    
-    Side effects:
-        metabMap : mut
-    
-    Returns:
-        None
-    """
-    for reactionId, values in fluxesEnrichmentRes.items():
-        pValue = values[0]
-        foldChange = values[1]
-        z_score = values[2]
-
-        if isinstance(foldChange, str): foldChange = float(foldChange)
-        if pValue >= ARGS.pValue: # pValue above tresh: dashed arrow
-            INSIGNIFICANT_ARROW.styleReactionElements(metabMap, reactionId)
-            INSIGNIFICANT_ARROW.styleReactionElements(metabMap, reactionId, mindReactionDir = False)
-
-            continue
-
-        if abs(foldChange) <  (ARGS.fChange - 1) / (abs(ARGS.fChange) + 1):
-            INVALID_ARROW.styleReactionElements(metabMap, reactionId)
-            INVALID_ARROW.styleReactionElements(metabMap, reactionId, mindReactionDir = False)
-
-            continue
-        
-        width = Arrow.MAX_W
-        if not math.isinf(foldChange):
-            try: 
-                width = max(abs(z_score * Arrow.MAX_W) / maxNumericZScore, Arrow.MIN_W) 
-
-            except ZeroDivisionError: pass
-        
-        #if not reactionId.endswith("_RV"): # RV stands for reversible reactions
-        #    Arrow(width, ArrowColor.fromFoldChangeSign(foldChange)).styleReactionElements(metabMap, reactionId)
-        #    continue
-        
-        #reactionId = reactionId[:-3] # Remove "_RV"
-        
-        inversionScore = (values[3] < 0) + (values[4] < 0) # Compacts the signs of averages into 1 easy to check score
-        if inversionScore == 2: foldChange *= -1
-        # ^^^ Style the inverse direction with the opposite sign netValue
-        
-        # If the score is 1 (opposite signs) we use alternative colors vvv
-        arrow = Arrow(width, ArrowColor.fromFoldChangeSign(foldChange, useAltColor = inversionScore == 1))
-        
-        # vvv These 2 if statements can both be true and can both happen
-        if ARGS.net: # style arrow head(s):
-            arrow.styleReactionElements(metabMap, reactionId + ("_B" if inversionScore == 2 else "_F"))
-            arrow.applyTo(("F_" if inversionScore == 2 else "B_") + reactionId, metabMap, f";stroke:{ArrowColor.Transparent};stroke-width:0;stroke-dasharray:None")
-
-        arrow.styleReactionElements(metabMap, reactionId, mindReactionDir = False)
-
-
-############################ split class ######################################
-def split_class(classes :pd.DataFrame, resolve_rules :Dict[str, List[float]]) -> Dict[str, List[List[float]]]:
-    """
-    Generates a :dict that groups together data from a :DataFrame based on classes the data is related to.
-
-    Args:
-        classes : a :DataFrame of only string values, containing class information (rows) and keys to query the resolve_rules :dict
-        resolve_rules : a :dict containing :float data
-
-    Returns:
-        dict : the dict with data grouped by class
-
-    Side effects:
-        classes : mut
-    """
-    class_pat :Dict[str, List[List[float]]] = {}
-    for i in range(len(classes)):
-        classe :str = classes.iloc[i, 1]
-        if pd.isnull(classe): continue
-
-        l :List[List[float]] = []
-        for j in range(i, len(classes)):
-            if classes.iloc[j, 1] == classe:
-                pat_id :str = classes.iloc[j, 0]
-                tmp = resolve_rules.get(pat_id, None)
-                if tmp != None:
-                    l.append(tmp)
-                classes.iloc[j, 1] = None
-        
-        if l:
-            class_pat[classe] = list(map(list, zip(*l)))
-            continue
-        
-        utils.logWarning(
-            f"Warning: no sample found in class \"{classe}\", the class has been disregarded", ARGS.out_log)
-    
-    return class_pat
-
-############################ conversion ##############################################
-#conversion from svg to png 
-def svg_to_png_with_background(svg_path :utils.FilePath, png_path :utils.FilePath, dpi :int = 72, scale :int = 1, size :Optional[float] = None) -> None:
-    """
-    Internal utility to convert an SVG to PNG (forced opaque) to aid in PDF conversion.
-
-    Args:
-        svg_path : path to SVG file
-        png_path : path for new PNG file
-        dpi : dots per inch of the generated PNG
-        scale : scaling factor for the generated PNG, computed internally when a size is provided
-        size : final effective width of the generated PNG
-
-    Returns:
-        None
-    """
-    if size:
-        image = pyvips.Image.new_from_file(svg_path.show(), dpi=dpi, scale=1)
-        scale = size / image.width
-        image = image.resize(scale)
-    else:
-        image = pyvips.Image.new_from_file(svg_path.show(), dpi=dpi, scale=scale)
-
-    white_background = pyvips.Image.black(image.width, image.height).new_from_image([255, 255, 255])
-    white_background = white_background.affine([scale, 0, 0, scale])
-
-    if white_background.bands != image.bands:
-        white_background = white_background.extract_band(0)
-
-    composite_image = white_background.composite2(image, 'over')
-    composite_image.write_to_file(png_path.show())
-
-#funzione unica, lascio fuori i file e li passo in input
-#conversion from png to pdf
-def convert_png_to_pdf(png_file :utils.FilePath, pdf_file :utils.FilePath) -> None:
-    """
-    Internal utility to convert a PNG to PDF to aid from SVG conversion.
-
-    Args:
-        png_file : path to PNG file
-        pdf_file : path to new PDF file
-
-    Returns:
-        None
-    """
-    image = Image.open(png_file.show())
-    image = image.convert("RGB")
-    image.save(pdf_file.show(), "PDF", resolution=100.0)
-
-#function called to reduce redundancy in the code
-def convert_to_pdf(file_svg :utils.FilePath, file_png :utils.FilePath, file_pdf :utils.FilePath) -> None:
-    """
-    Converts the SVG map at the provided path to PDF.
-
-    Args:
-        file_svg : path to SVG file
-        file_png : path to PNG file
-        file_pdf : path to new PDF file
-
-    Returns:
-        None
-    """
-    svg_to_png_with_background(file_svg, file_png)
-    try:
-        convert_png_to_pdf(file_png, file_pdf)
-        print(f'PDF file {file_pdf.filePath} successfully generated.')
-    
-    except Exception as e:
-        raise utils.DataErr(file_pdf.show(), f'Error generating PDF file: {e}')
-
-############################ map ##############################################
-def buildOutputPath(dataset1Name :str, dataset2Name = "rest", *, details = "", ext :utils.FileFormat) -> utils.FilePath:
-    """
-    Builds a FilePath instance from the names of confronted datasets ready to point to a location in the
-    "result/" folder, used by this tool for output files in collections.
-
-    Args:
-        dataset1Name : _description_
-        dataset2Name : _description_. Defaults to "rest".
-        details : _description_
-        ext : _description_
-
-    Returns:
-        utils.FilePath : _description_
-    """
-    # This function returns a util data structure but is extremely specific to this module.
-    # RAS also uses collections as output and as such might benefit from a method like this, but I'd wait
-    # TODO: until a third tool with multiple outputs appears before porting this to utils.
-    return utils.FilePath(
-        f"{dataset1Name}_vs_{dataset2Name}" + (f" ({details})" if details else ""),
-        # ^^^ yes this string is built every time even if the form is the same for the same 2 datasets in
-        # all output files: I don't care, this was never the performance bottleneck of the tool and
-        # there is no other net gain in saving and re-using the built string.
-        ext,
-        prefix = "result")
-
-FIELD_NOT_AVAILABLE = '/'
-def writeToCsv(rows: List[list], fieldNames :List[str], outPath :utils.FilePath) -> None:
-    fieldsAmt = len(fieldNames)
-    with open(outPath.show(), "w", newline = "") as fd:
-        writer = csv.DictWriter(fd, fieldnames = fieldNames, delimiter = '\t')
-        writer.writeheader()
-        
-        for row in rows:
-            sizeMismatch = fieldsAmt - len(row)
-            if sizeMismatch > 0: row.extend([FIELD_NOT_AVAILABLE] * sizeMismatch)
-            writer.writerow({ field : data for field, data in zip(fieldNames, row) })
-
-OldEnrichedScores = Dict[str, List[Union[float, FoldChange]]] #TODO: try to use Tuple whenever possible
-def writeTabularResult(enrichedScores : OldEnrichedScores, outPath :utils.FilePath) -> None:
-    fieldNames = ["ids", "P_Value", "fold change"]
-    fieldNames.extend(["average_1", "average_2"])
-
-    writeToCsv([ [reactId] + values for reactId, values in enrichedScores.items() ], fieldNames, outPath)
-
-def temp_thingsInCommon(tmp :Dict[str, List[Union[float, FoldChange]]], core_map :ET.ElementTree, max_z_score :float, dataset1Name :str, dataset2Name = "rest") -> None:
-    # this function compiles the things always in common between comparison modes after enrichment.
-    # TODO: organize, name better.
-    writeTabularResult(tmp, buildOutputPath(dataset1Name, dataset2Name, details = "Tabular Result", ext = utils.FileFormat.TSV))
-    for reactId, enrichData in tmp.items(): tmp[reactId] = tuple(enrichData)
-    applyFluxesEnrichmentToMap(tmp, core_map, max_z_score)
-
-def computePValue(dataset1Data: List[float], dataset2Data: List[float]) -> Tuple[float, float]:
-    """
-    Computes the statistical significance score (P-value) of the comparison between coherent data
-    from two datasets. The data is supposed to, in both datasets:
-    - be related to the same reaction ID;
-    - be ordered by sample, such that the item at position i in both lists is related to the
-      same sample or cell line.
-
-    Args:
-        dataset1Data : data from the 1st dataset.
-        dataset2Data : data from the 2nd dataset.
-
-    Returns:
-        tuple: (P-value, Z-score)
-            - P-value from a Kolmogorov-Smirnov test on the provided data.
-            - Z-score of the difference between means of the two datasets.
-    """
-    # Perform Kolmogorov-Smirnov test
-    ks_statistic, p_value = st.ks_2samp(dataset1Data, dataset2Data)
-    
-    # Calculate means and standard deviations
-    mean1 = np.mean(dataset1Data)
-    mean2 = np.mean(dataset2Data)
-    std1 = np.std(dataset1Data, ddof=1)
-    std2 = np.std(dataset2Data, ddof=1)
-    
-    n1 = len(dataset1Data)
-    n2 = len(dataset2Data)
-    
-    # Calculate Z-score
-    z_score = (mean1 - mean2) / np.sqrt((std1**2 / n1) + (std2**2 / n2))
-    
-    return p_value, z_score
-
-def compareDatasetPair(dataset1Data :List[List[float]], dataset2Data :List[List[float]], ids :List[str]) -> Tuple[Dict[str, List[Union[float, FoldChange]]], float]:
-    #TODO: the following code still suffers from "dumbvarnames-osis"
-    tmp :Dict[str, List[Union[float, FoldChange]]] = {}
-    count   = 0
-    max_z_score = 0
-
-    for l1, l2 in zip(dataset1Data, dataset2Data):
-        reactId = ids[count]
-        count += 1
-        if not reactId: continue # we skip ids that have already been processed
-
-        try: 
-            p_value, z_score = computePValue(l1, l2)
-            avg1 = sum(l1) / len(l1)
-            avg2 = sum(l2) / len(l2)
-            avg = fold_change(avg1, avg2)
-            if not isinstance(z_score, str) and max_z_score < abs(z_score): max_z_score = abs(z_score)
-            tmp[reactId] = [float(p_value), avg, z_score, avg1, avg2]
-        except (TypeError, ZeroDivisionError): continue
-    
-    return tmp, max_z_score
-
-def computeEnrichment(metabMap :ET.ElementTree, class_pat :Dict[str, List[List[float]]], ids :List[str]) -> None:
-    """
-    Compares clustered data based on a given comparison mode and applies enrichment-based styling on the
-    provided metabolic map.
-
-    Args:
-        metabMap : SVG map to modify.
-        class_pat : the clustered data.
-        ids : ids for data association.
-        
-
-    Returns:
-        None
-
-    Raises:
-        sys.exit : if there are less than 2 classes for comparison
-    
-    Side effects:
-        metabMap : mut
-        ids : mut
-    """
-    class_pat = { k.strip() : v for k, v in class_pat.items() }
-    #TODO: simplfy this stuff vvv and stop using sys.exit (raise the correct utils error)
-    if (not class_pat) or (len(class_pat.keys()) < 2): sys.exit('Execution aborted: classes provided for comparisons are less than two\n')
-
-    if ARGS.comparison == "manyvsmany":
-        for i, j in it.combinations(class_pat.keys(), 2):
-            #TODO: these 2 functions are always called in pair and in this order and need common data,
-            # some clever refactoring would be appreciated.
-            comparisonDict, max_z_score = compareDatasetPair(class_pat.get(i), class_pat.get(j), ids)
-            temp_thingsInCommon(comparisonDict, metabMap, max_z_score, i, j)
-    
-    elif ARGS.comparison == "onevsrest":
-        for single_cluster in class_pat.keys():
-            t :List[List[List[float]]] = []
-            for k in class_pat.keys():
-                if k != single_cluster:
-                   t.append(class_pat.get(k))
-            
-            rest :List[List[float]] = []
-            for i in t:
-                rest = rest + i
-            
-            comparisonDict, max_z_score = compareDatasetPair(class_pat.get(single_cluster), rest, ids)
-            temp_thingsInCommon(comparisonDict, metabMap, max_z_score, single_cluster)
-    
-    elif ARGS.comparison == "onevsmany":
-        controlItems = class_pat.get(ARGS.control)
-        for otherDataset in class_pat.keys():
-            if otherDataset == ARGS.control: continue
-            
-            comparisonDict, max_z_score = compareDatasetPair(controlItems, class_pat.get(otherDataset), ids)
-            temp_thingsInCommon(comparisonDict, metabMap, max_z_score, ARGS.control, otherDataset)
-
-def createOutputMaps(dataset1Name :str, dataset2Name :str, core_map :ET.ElementTree) -> None:
-    svgFilePath = buildOutputPath(dataset1Name, dataset2Name, details = "SVG Map", ext = utils.FileFormat.SVG)
-    utils.writeSvg(svgFilePath, core_map)
-
-    if ARGS.generate_pdf:
-        pngPath = buildOutputPath(dataset1Name, dataset2Name, details = "PNG Map", ext = utils.FileFormat.PNG)
-        pdfPath = buildOutputPath(dataset1Name, dataset2Name, details = "PDF Map", ext = utils.FileFormat.PDF)
-        convert_to_pdf(svgFilePath, pngPath, pdfPath)                     
-
-    if not ARGS.generate_svg: os.remove(svgFilePath.show())
-
-ClassPat = Dict[str, List[List[float]]]
-def getClassesAndIdsFromDatasets(datasetsPaths :List[str], datasetPath :str, classPath :str, names :List[str]) -> Tuple[List[str], ClassPat]:
-    # TODO: I suggest creating dicts with ids as keys instead of keeping class_pat and ids separate,
-    # for the sake of everyone's sanity.
-    class_pat :ClassPat = {}
-    if ARGS.option == 'datasets':
-        num = 1 #TODO: the dataset naming function could be a generator
-        for path, name in zip(datasetsPaths, names):
-            name = name_dataset(name, num)
-            resolve_rules_float, ids = getDatasetValues(path, name)
-            if resolve_rules_float != None:
-                class_pat[name] = list(map(list, zip(*resolve_rules_float.values())))
-        
-            num += 1
-    
-    elif ARGS.option == "dataset_class":
-        classes = read_dataset(classPath, "class")
-        classes = classes.astype(str)
-
-        resolve_rules_float, ids = getDatasetValues(datasetPath, "Dataset Class (not actual name)")
-        if resolve_rules_float != None: class_pat = split_class(classes, resolve_rules_float)
-    
-    return ids, class_pat
-    #^^^ TODO: this could be a match statement over an enum, make it happen future marea dev with python 3.12! (it's why I kept the ifs)
-
-#TODO: create these damn args as FilePath objects
-def getDatasetValues(datasetPath :str, datasetName :str) -> Tuple[ClassPat, List[str]]:
-    """
-    Opens the dataset at the given path and extracts the values (expected nullable numerics) and the IDs.
-
-    Args:
-        datasetPath : path to the dataset
-        datasetName (str): dataset name, used in error reporting
-
-    Returns:
-        Tuple[ClassPat, List[str]]: values and IDs extracted from the dataset
-    """
-    dataset = read_dataset(datasetPath, datasetName)
-    IDs = pd.Series.tolist(dataset.iloc[:, 0].astype(str))
-
-    dataset = dataset.drop(dataset.columns[0], axis = "columns").to_dict("list")
-    return { id : list(map(utils.Float("Dataset values, not an argument"), values)) for id, values in dataset.items() }, IDs
-
-def rgb_to_hex(rgb):
-    """
-    Convert RGB values (0-1 range) to hexadecimal color format.
-
-    Args:
-        rgb (numpy.ndarray): An array of RGB color components (in the range [0, 1]).
-
-    Returns:
-        str: The color in hexadecimal format (e.g., '#ff0000' for red).
-    """
-    # Convert RGB values (0-1 range) to hexadecimal format
-    rgb = (np.array(rgb) * 255).astype(int)
-    return '#{:02x}{:02x}{:02x}'.format(rgb[0], rgb[1], rgb[2])
-
-
-
-def save_colormap_image(min_value: float, max_value: float, path: utils.FilePath, colorMap:str="viridis"):
-    """
-    Create and save an image of the colormap showing the gradient and its range.
-
-    Args:
-        min_value (float): The minimum value of the colormap range.
-        max_value (float): The maximum value of the colormap range.
-        filename (str): The filename for saving the image.
-    """
-
-    # Create a colormap using matplotlib
-    cmap = plt.get_cmap(colorMap)
-
-    # Create a figure and axis
-    fig, ax = plt.subplots(figsize=(6, 1))
-    fig.subplots_adjust(bottom=0.5)
-
-    # Create a gradient image
-    gradient = np.linspace(0, 1, 256)
-    gradient = np.vstack((gradient, gradient))
-
-    # Add min and max value annotations
-    ax.text(0, 0.5, f'{np.round(min_value, 3)}', va='center', ha='right', transform=ax.transAxes, fontsize=12, color='black')
-    ax.text(1, 0.5, f'{np.round(max_value, 3)}', va='center', ha='left', transform=ax.transAxes, fontsize=12, color='black')
-
-
-    # Display the gradient image
-    ax.imshow(gradient, aspect='auto', cmap=cmap)
-    ax.set_axis_off()
-
-    # Save the image
-    plt.savefig(path.show(), bbox_inches='tight', pad_inches=0)
-    plt.close()
-    pass
-
-def min_nonzero_abs(arr):
-    # Flatten the array and filter out zeros, then find the minimum of the remaining values
-    non_zero_elements = np.abs(arr)[np.abs(arr) > 0]
-    return np.min(non_zero_elements) if non_zero_elements.size > 0 else None
-
-def computeEnrichmentMeanMedian(metabMap: ET.ElementTree, class_pat: Dict[str, List[List[float]]], ids: List[str], colormap:str) -> None:
-    """
-    Compute and visualize the metabolic map based on mean and median of the input fluxes.
-    The fluxes are normalised across classes/datasets and visualised using the given colormap.
-
-    Args:
-        metabMap (ET.ElementTree): An XML tree representing the metabolic map.
-        class_pat (Dict[str, List[List[float]]]): A dictionary where keys are class names and values are lists of enrichment values.
-        ids (List[str]): A list of reaction IDs to be used for coloring arrows.
-    
-    Returns:
-        None
-    """
-    # Create copies only if they are needed
-    metabMap_mean = copy.deepcopy(metabMap)
-    metabMap_median = copy.deepcopy(metabMap)
-
-    # Compute medians and means
-    medians = {key: np.round(np.median(np.array(value), axis=1), 6) for key, value in class_pat.items()}
-    means = {key: np.round(np.mean(np.array(value), axis=1),6) for key, value in class_pat.items()}
-
-    # Normalize medians and means
-    max_flux_medians = max(np.max(np.abs(arr)) for arr in medians.values())
-    max_flux_means = max(np.max(np.abs(arr)) for arr in means.values())
-
-    min_flux_medians = min(min_nonzero_abs(arr) for arr in medians.values())
-    min_flux_means = min(min_nonzero_abs(arr) for arr in means.values())
-
-    medians = {key: median/max_flux_medians for key, median in medians.items()}
-    means = {key: mean/max_flux_means for key, mean in means.items()}
-
-    save_colormap_image(min_flux_medians, max_flux_medians, utils.FilePath("Color map median", ext=utils.FileFormat.PNG, prefix="result"), colormap)
-    save_colormap_image(min_flux_means, max_flux_means, utils.FilePath("Color map mean", ext=utils.FileFormat.PNG, prefix="result"), colormap)
-
-    cmap = plt.get_cmap(colormap)
-
-    for key in class_pat:
-        # Create color mappings for median and mean
-        colors_median = {
-            rxn_id: rgb_to_hex(cmap(abs(medians[key][i]))) if medians[key][i] != 0 else '#bebebe'  #grey blocked
-            for i, rxn_id in enumerate(ids)
-        }
-
-        colors_mean = {
-            rxn_id: rgb_to_hex(cmap(abs(means[key][i]))) if means[key][i] != 0 else '#bebebe'  #grey blocked
-            for i, rxn_id in enumerate(ids)
-        }
-
-        for i, rxn_id in enumerate(ids):
-            isNegative = medians[key][i] < 0
-
-            # Apply median arrows
-            apply_arrow(metabMap_median, rxn_id, colors_median[rxn_id], isNegative)
-
-            isNegative = means[key][i] < 0
-            # Apply mean arrows
-            apply_arrow(metabMap_mean, rxn_id, colors_mean[rxn_id], isNegative)
-
-        # Save and convert the SVG files
-        save_and_convert(metabMap_mean, "mean", key)
-        save_and_convert(metabMap_median, "median", key)
-
-def apply_arrow(metabMap, rxn_id, color, isNegative):
-    """
-    Apply an arrow to a specific reaction in the metabolic map with a given color.
-
-    Args:
-        metabMap (ET.ElementTree): An XML tree representing the metabolic map.
-        rxn_id (str): The ID of the reaction to which the arrow will be applied.
-        color (str): The color of the arrow in hexadecimal format.
-
-    Returns:
-        None
-    """
-    arrow = Arrow(width=5, col=color)
-    arrow.styleReactionElementsMeanMedian(metabMap, rxn_id, isNegative)
-    pass
-
-def save_and_convert(metabMap, map_type, key):
-    """
-    Save the metabolic map as an SVG file and optionally convert it to PNG and PDF formats.
-
-    Args:
-        metabMap (ET.ElementTree): An XML tree representing the metabolic map.
-        map_type (str): The type of map ('mean' or 'median').
-        key (str): The key identifying the specific map.
-
-    Returns:
-        None
-    """
-    svgFilePath = utils.FilePath(f"SVG Map {map_type} - {key}", ext=utils.FileFormat.SVG, prefix="result")
-    utils.writeSvg(svgFilePath, metabMap)
-    if ARGS.generate_pdf:
-        pngPath = utils.FilePath(f"PNG Map {map_type} - {key}", ext=utils.FileFormat.PNG, prefix="result")
-        pdfPath = utils.FilePath(f"PDF Map {map_type} - {key}", ext=utils.FileFormat.PDF, prefix="result")
-        convert_to_pdf(svgFilePath, pngPath, pdfPath)
-    if not ARGS.generate_svg:
-        os.remove(svgFilePath.show())
-
-
-
-    
-############################ MAIN #############################################
-def main() -> None:
-    """
-    Initializes everything and sets the program in motion based on the fronted input arguments.
-
-    Returns:
-        None
-    
-    Raises:
-        sys.exit : if a user-provided custom map is in the wrong format (ET.XMLSyntaxError, ET.XMLSchemaParseError)
-    """
-
-    global ARGS
-    ARGS = process_args()
-
-    if os.path.isdir('result') == False: os.makedirs('result')
-    
-    core_map :ET.ElementTree = ARGS.choice_map.getMap(
-        ARGS.tool_dir,
-        utils.FilePath.fromStrPath(ARGS.custom_map) if ARGS.custom_map else None)
-    # TODO: ^^^ ugly but fine for now, the argument is None if the model isn't custom because no file was given.
-    # getMap will None-check the customPath and panic when the model IS custom but there's no file (good). A cleaner
-    # solution can be derived from my comment in FilePath.fromStrPath
-
-    ids, class_pat = getClassesAndIdsFromDatasets(ARGS.input_datas_fluxes, ARGS.input_data_fluxes, ARGS.input_class_fluxes, ARGS.names_fluxes)
-
-    if(ARGS.choice_map == utils.Model.HMRcore):
-        temp_map = utils.Model.HMRcore_no_legend
-        computeEnrichmentMeanMedian(temp_map.getMap(ARGS.tool_dir), class_pat, ids, ARGS.color_map)
-    elif(ARGS.choice_map == utils.Model.ENGRO2):
-        temp_map = utils.Model.ENGRO2_no_legend
-        computeEnrichmentMeanMedian(temp_map.getMap(ARGS.tool_dir), class_pat, ids, ARGS.color_map)
-    else:
-        computeEnrichmentMeanMedian(core_map, class_pat, ids, ARGS.color_map)
-    
-
-    computeEnrichment(core_map, class_pat, ids)
-    
-    # create output files: TODO: this is the same comparison happening in "maps", find a better way to organize this
-    if ARGS.comparison == "manyvsmany":
-        for i, j in it.combinations(class_pat.keys(), 2): createOutputMaps(i, j, core_map)
-        return
-    
-    if ARGS.comparison == "onevsrest":
-        for single_cluster in class_pat.keys(): createOutputMaps(single_cluster, "rest", core_map)
-        return
-    
-    for otherDataset in class_pat.keys():
-        if otherDataset != ARGS.control: createOutputMaps(i, j, core_map)
-
-    if not ERRORS: return
-    utils.logWarning(
-        f"The following reaction IDs were mentioned in the dataset but weren't found in the map: {ERRORS}",
-        ARGS.out_log)
-    
-    print('Execution succeded')
-
-###############################################################################
-if __name__ == "__main__":
-    main()
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/flux_to_map.xml	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,244 +0,0 @@
-<tool id="FluxToMap" name="Metabolic Flux Enrichment Analysis" version="2.0.0">
-	<macros>
-		<import>marea_macros.xml</import>
-	</macros>
-	
-	<requirements>
-		<requirement type="package" version="1.24.4">numpy</requirement>
-        <requirement type="package" version="2.0.3">pandas</requirement>
-		<requirement type="package" version="0.13.0">seaborn</requirement>
-        <requirement type="package" version="1.10.1">scipy</requirement>
-		<requirement type="package" version="1.5.1">svglib</requirement>
-		<requirement type="package" version="2.2.3">pyvips</requirement>
-		<requirement type="package" version="2.7.1">cairosvg</requirement>
-		<requirement type="package" version="0.29.0">cobra</requirement>
-		<requirement type="package" version="5.2.2">lxml</requirement>
-	</requirements>
-	
-	<command detect_errors="exit_code">
-		<![CDATA[
-      	python $__tool_directory__/flux_to_map.py
-
-      	--tool_dir $__tool_directory__
-      	--option $cond.type_selector
-        --out_log $log
-		--color_map $color_map
-	
-        #if $cond.type_selector == 'datasets':
-
-			--input_datas_fluxes
-			#for $data in $cond.input_datasets_fluxes:
-				${data.input_fluxes}
-			#end for
-
-			--names_fluxes
-			#for $data in $cond.input_datasets_fluxes:
-				${data.input_name_fluxes}
-			#end for
-
-        #elif $cond.type_selector == 'dataset_class':
-
-			--input_data_fluxes $input_data_fluxes
-			--input_class_fluxes $input_class_fluxes
-
-        #end if
-
-		--comparison ${comparis.comparison}
-		#if $comparis.comparison == 'onevsmany'
-			--control '${cond.comparis.controlgroup}'
-		#end if
-
-		--choice_map '${cond_choice_map.choice_map}'
-		#if $cond_choice_map.choice_map == 'Custom':
-			--custom_map ${cond_choice_map.custom_map}
-		#end if
-		
-		#if $advanced.choice == 'true':
-			--pValue ${advanced.pValue}
-			--fChange ${advanced.fChange}
-			--generate_svg ${advanced.generateSvg}
-			--generate_pdf ${advanced.generatePdf}
-		#else 
-			--pValue 0.05
-			--fChange 1.2
-			--generate_svg false
-			--generate_pdf true
-		#end if
-        ]]>
-	</command>
-	
-	<inputs>
-
-		<conditional name="cond">
-			<param name="type_selector" argument="--option" type="select" label="Input format:">
-				<option value="datasets" selected="true">Fluxes of group 1 + Fluxes of group 2 + ... + Fluxes of group N</option>
-				<option value="dataset_class">All fluxes + sample group specification</option>
-			</param>
-
-			<when value="datasets">
-				<repeat name="input_datasets_fluxes" title="Fluxes dataset" min="2">
-					<param name="input_fluxes" argument="--input_datas_fluxes" type="data" format="tabular, csv, tsv" label="add dataset" />
-					<param name="input_name_fluxes" argument="--names_fluxes" type="text" label="Dataset's name:" value="Dataset" help="Default: Dataset" />
-				</repeat>
-			</when>
-
-			<when value="dataset_class">
-				<param name="input_data_fluxes" argument="--input_data_fluxes" type="data" format="tabular, csv, tsv" label="All fluxes" />
-				<param name="input_class_fluxes" argument="--input_class_fluxes" type="data" format="tabular, csv, tsv" label="Sample group specification" />
-			</when>
-		</conditional>
-
-		<conditional name="comparis">
-			<param name="comparison" argument="--comparison" type="select" label="Groups comparison:">
-				<option value="manyvsmany" selected="true">One vs One</option>
-				<option value="onevsrest">One vs All</option>
-				<option value="onevsmany">One vs Control</option>
-			</param>
-			<when value="onevsmany">
-				<param name="controlgroup" argument="--controlgroup" type="text" label="Control group label:" value="0" help="Name of group label to be compared to others"/>
-			</when>
-		</conditional>
-		
-		<conditional name="cond_choice_map">
-			<param name="choice_map" argument="--choice_map" type="select" label="Choose metabolic map:">
-				<option value="ENGRO2" selected="true">ENGRO2</option>
-				<option value="HMRcore" >HMRcore</option>
-				<option value="Custom">Custom</option>
-			</param>
-
-			<when value="Custom">				
-				<param name="custom_map" argument="--custom_map" type="data" format="xml, svg" label="custom-map.svg"/>
-			</when>
-		</conditional>
-
-		<param name="color_map" argument="--color_map" type="select" label="Color map:">
-				<option value="viridis" selected="true">Viridis</option>
-				<option value="jet">Jet</option>
-		</param>
-
-		<conditional name="advanced">
-			<param name="choice" type="boolean" checked="false" label="Use advanced options?" help="Use this options to choose custom parameters for evaluation: pValue, Fold-Change threshold, how to solve (A and NaN) and specify output maps.">
-				<option value="true" selected="true">No</option>
-				<option value="false">Yes</option>
-			</param>
-
-			<when value="true">
-				<param name="pValue" argument="--pValue" type="float" size="20" value="0.05" max="1" min="0" label="P-value threshold:" help="min value 0" />
-				<param name="fChange" argument="--fChange" type="float" size="20" value="1.2" min="1" label="Fold-Change threshold:" help="min value 1" />
-				<param name="generateSvg" argument="--generateSvg" type="boolean" checked="false" label="Generate SVG map" help="should the program generate an editable svg map of the processes?" />
-				<param name="generatePdf" argument="--generatePdf" type="boolean" checked="true" label="Generate PDF map" help="should the program return a non editable (but displayble) pdf map of the processes?" />
-			</when>
-		</conditional>
-	</inputs>
-
-	<outputs>
-		<data format="txt" name="log" label="FluxToMap - Log" />
-		<collection name="results" type="list" label="FluxToMap - Results">
-			<discover_datasets pattern="__name_and_ext__" directory="result"/>
-		</collection>
-	</outputs>
-	
-	<help>
-	<![CDATA[
-
-What it does
--------------
-
-This tool analyzes and visualizes differences in reactions fluxes of groups of samples, returned by the Flux Simulation tool, of groups of samples.
-
-Accepted files are: 
-    - option 1) two or more fluxes datasets, each referring to samples in a given group. The user can specify a label for each group;
-    - option 2) one fluxes dataset and one group-file specifying the group each sample belongs to (e.g. the accepted group file is thought to be the one returned by the Clustering tool).
-
-Optional files:
-    - custom svg map. Graphical elements must have the same IDs of reactions. See HmrCore svg map for an example.
-
-The tool generates:
-    - 1) a tab-separated file: reporting fold-change and p-values of fluxes between a pair of conditions/classes;
-    - 2) a metabolic map file (downloadable as .svg): visualizing up- and down-regulated reactions between a pair of conditions/classes;
-    - 3) a log file (.txt).
-    
-Output options:
-To calculate P-Values and Fold-Changes and to enrich maps, comparisons are performed for each possible pair of groups (default option ‘One vs One’).
-
-Alternative options are:
-    - comparison of each group vs. the rest of samples (option ‘One vs Rest’)
-    - comparison of each group vs. a control group (option ‘One vs Control). If this option is selected the user must indicate the control group label.
-
-Output files will be named as classA_vs_classB. Reactions will conventionally be reported as up-regulated (down-regulated) if they are significantly more (less) active in class having label "classA".
-
-Example input
--------------
-
-"Fluxes of group 1 + Fluxes of group 2 + ... + Fluxes of group N" option:
-
-Fluxes Dataset 1:
-
-+------------+----------------+----------------+----------------+ 
-| Reaction ID|   TCGAA62670   |   TCGAA62671   |   TCGAA62672   |  
-+============+================+================+================+
-| r1642      |    0.523167    |    0.371355    |    0.925661    |  
-+------------+----------------+----------------+----------------+    
-| r1643      |    0.568765    |    0.765567    |    0.456789    |    
-+------------+----------------+----------------+----------------+    
-| r1640      |    0.876545    |    0.768933    |    0.987654    |  
-+------------+----------------+----------------+----------------+
-| r1641      |    0.456788    |    0.876543    |    0.876542    |    
-+------------+----------------+----------------+----------------+    
-| r1646      |    0.876543    |    0.786543    |    0.897654    |   
-+------------+----------------+----------------+----------------+
-
-Fluxes Dataset 2:
-
-+------------+----------------+----------------+----------------+ 
-| Reaction ID|   TCGAA62670   |   TCGAA62671   |   TCGAA62672   |  
-+============+================+================+================+
-| r1642      |    0.523167    |    0.371355    |    0.925661    |  
-+------------+----------------+----------------+----------------+    
-| r1643      |    0.568765    |    0.765567    |    0.456789    |    
-+------------+----------------+----------------+----------------+    
-| r1640      |    0.876545    |    0.768933    |    0.987654    |  
-+------------+----------------+----------------+----------------+
-| r1641      |    0.456788    |    0.876543    |    0.876542    |    
-+------------+----------------+----------------+----------------+    
-| r1646      |    0.876543    |    0.786543    |    0.897654    |   
-+------------+----------------+----------------+----------------+
-
-"Fluxes of all samples + sample group specification" option:
-
-Fluxes Dataset:
-
-+------------+----------------+----------------+----------------+ 
-| Reaction ID|   TCGAA62670   |   TCGAA62671   |   TCGAA62672   |  
-+============+================+================+================+
-| r1642      |    0.523167    |    0.371355    |    0.925661    |  
-+------------+----------------+----------------+----------------+    
-| r1643      |    0.568765    |    0.765567    |    0.456789    |    
-+------------+----------------+----------------+----------------+    
-| r1640      |    0.876545    |    0.768933    |    0.987654    |  
-+------------+----------------+----------------+----------------+
-| r1641      |    0.456788    |    0.876543    |    0.876542    |    
-+------------+----------------+----------------+----------------+    
-| r1646      |    0.876543    |    0.786543    |    0.897654    |   
-+------------+----------------+----------------+----------------+
-
-Group-file
-
-+---------------+-----------+
-| Patient ID    |   Class   | 
-+===============+===========+
-| TCGAAA3529    |    MSI    | 
-+---------------+-----------+  
-| TCGAA62671    |    MSS    |    
-+---------------+-----------+   
-| TCGAA62672    |    MSI    |
-+---------------+-----------+
-
-
-**TIP**: If your dataset is not split into classes, use MaREA cluster analysis.
-
-
-]]>
-	</help>
-	<expand macro="citations" />
-</tool>
\ No newline at end of file

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/local/ENGRO2_rules.csv	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,458 +0,0 @@
-,0
-EX_lac__L_e,
-EX_glc__D_e,
-EX_glu__L_e,
-EX_gln__L_e,
-EX_asp__L_e,
-EX_co2_e,
-EX_h_e,
-EX_h2o_e,
-EX_pi_e,
-EX_nh4_e,
-EX_o2_e,
-EX_arg__L_e,
-EX_pro__L_e,
-EX_leu__L_e,
-EX_ile__L_e,
-EX_met__L_e,
-EX_gly_e,
-EX_phe__L_e,
-EX_ser__L_e,
-EX_ala__L_e,
-EX_asn__L_e,
-EX_fol_e,
-EX_urea_e,
-EX_pyr_e,
-PYRt2,ENSG00000118596 or ENSG00000141526 or ENSG00000155380
-EX_gudac_e,
-EX_hdca_e,
-EX_ptrc_e,
-EX_biomassx,
-EX_gthox_e,
-EX_2obut_e,
-EX_val__L_e,
-EX_spmd_e,
-EX_sprm_e,
-EX_5mthf_e,
-EX_crtn_e,
-EX_his__L_e,
-EX_lys__L_e,
-EX_cys__L_e,
-EX_so3_e,
-EX_thr__L_e,
-EX_trp__L_e,
-EX_anth_e,
-EX_tyr__L_e,
-EX_Lcystin_e,
-EX_gthrd_e,
-HEX1,ENSG00000106633 or ENSG00000156510 or ENSG00000156515 or ENSG00000159399 or ENSG00000160883
-G6PP,ENSG00000131482 or ENSG00000141349 or ENSG00000152254
-PGI,ENSG00000105220
-PFK,ENSG00000067057 or ENSG00000141959 or ENSG00000152556
-FBP,ENSG00000130957 or ENSG00000165140
-FBA,ENSG00000109107 or ENSG00000136872 or ENSG00000149925
-TPI,ENSG00000111669
-GAPD,ENSG00000105679 or ENSG00000111640
-PGK,ENSG00000102144 or ENSG00000170950
-DPGM,ENSG00000164708 or ENSG00000171314 or ENSG00000172331
-DPGase,ENSG00000164708 or ENSG00000171314 or ENSG00000172331
-PGM,ENSG00000164708 or ENSG00000171314 or ENSG00000172331
-ENO,ENSG00000074800 or ENSG00000108515 or ENSG00000111674
-PYK,ENSG00000067225 or ENSG00000143627
-LDH_L,ENSG00000111716 or ENSG00000134333 or ENSG00000151116 or ENSG00000166796 or ENSG00000166800 or ENSG00000171989
-r0407,ENSG00000109107 or ENSG00000136872 or ENSG00000149925
-PRPPS,ENSG00000101911 or ENSG00000147224 or ENSG00000229937
-G6PDH2r,ENSG00000160211
-PGL,ENSG00000049239 or ENSG00000130313
-GND,ENSG00000142657
-RPI,ENSG00000153574
-TKT2,ENSG00000007350 or ENSG00000151005 or ENSG00000163931
-RPE,ENSG00000197713 or ENSG00000235376
-TKT1,ENSG00000007350 or ENSG00000151005 or ENSG00000163931
-TALA,ENSG00000177156
-r0408,ENSG00000067057 or ENSG00000141959 or ENSG00000152556
-PDHm,ENSG00000091140 and ENSG00000110435 and ENSG00000150768 and ENSG00000168291 and (ENSG00000131828 or ENSG00000163114)
-PCm,ENSG00000173599
-PEPCK_re,ENSG00000124253
-CSm,ENSG00000062485
-ACONTm,ENSG00000100412 or ENSG00000122729
-ICDHxm,ENSG00000067829 and ENSG00000101365 and ENSG00000166411
-ICDHym,ENSG00000182054
-AKGDm,ENSG00000091140 and ENSG00000105953 and ENSG00000119689
-SUCOAS1m,ENSG00000163541 and ENSG00000172340
-SUCD1m,ENSG00000073578 and ENSG00000117118 and ENSG00000143252 and ENSG00000204370
-FUMm,ENSG00000091483
-MDHm,ENSG00000146701
-ME1m,ENSG00000082212
-ME2m,ENSG00000151376
-ME2,ENSG00000065833
-ACITL,ENSG00000131473
-FUM,ENSG00000091483
-MDH,ENSG00000014641 or ENSG00000138400
-AKGMALtm,ENSG00000108528 or ENSG00000183048
-ACONT,ENSG00000122729
-ICDHyr,ENSG00000138413
-PPA,ENSG00000107902 or ENSG00000180817
-Complex1ROS,ENSG00000004779 and ENSG00000023228 and ENSG00000065518 and ENSG00000090266 and ENSG00000099795 and ENSG00000109390 and ENSG00000110717 and ENSG00000115286 and ENSG00000119013 and ENSG00000119421 and ENSG00000125356 and ENSG00000128609 and ENSG00000130414 and ENSG00000131495 and ENSG00000136521 and ENSG00000139180 and ENSG00000140990 and ENSG00000147123 and ENSG00000147684 and ENSG00000151366 and ENSG00000158864 and ENSG00000165264 and ENSG00000166136 and ENSG00000167792 and ENSG00000168653 and ENSG00000170906 and ENSG00000174886 and ENSG00000178127 and ENSG00000183648 and ENSG00000184983 and ENSG00000186010 and ENSG00000198695 and ENSG00000198763 and ENSG00000198786 and ENSG00000198840 and ENSG00000198886 and ENSG00000198888 and ENSG00000212907 and ENSG00000213619
-FADH2ETC,ENSG00000171503 and ENSG00000105379 and ENSG00000140374
-CYOR_u10mi,ENSG00000010256 and ENSG00000127540 and ENSG00000140740 and ENSG00000156467 and ENSG00000164405 and ENSG00000169021 and ENSG00000173660 and ENSG00000179091 and ENSG00000184076 and ENSG00000198727
-CYOOm2i,ENSG00000127184 and ENSG00000135940 and ENSG00000164919 and ENSG00000178741 and ENSG00000198712 and ENSG00000198804 and ENSG00000198938 and (ENSG00000111775 or ENSG00000156885) and (ENSG00000112695 or ENSG00000161281) and (ENSG00000126267 or ENSG00000160471) and (ENSG00000131055 or ENSG00000131143) and (ENSG00000131174 or ENSG00000170516) and (ENSG00000176340 or ENSG00000187581)
-ATPS4mi,ENSG00000099624 and ENSG00000110955 and ENSG00000116459 and ENSG00000124172 and ENSG00000152234 and ENSG00000154723 and ENSG00000165629 and ENSG00000167283 and ENSG00000167863 and ENSG00000169020 and ENSG00000198899 and ENSG00000228253 and ENSG00000241468 and ENSG00000241837 and (ENSG00000135390 or ENSG00000154518 or ENSG00000159199)
-GLUCYS,ENSG00000001084 and ENSG00000023909
-GTHS,ENSG00000100983
-SPODMm,ENSG00000112096
-GTHPi,ENSG00000117450 or ENSG00000167468 or ENSG00000167815 or ENSG00000176153 or ENSG00000233276
-GTHPm,ENSG00000165672 or ENSG00000167468 or ENSG00000233276
-GDR,ENSG00000104687
-GTHOr,ENSG00000104687
-GDRm,ENSG00000104687
-GTHOm,ENSG00000104687
-r0885,ENSG00000183048
-PYRt2m,ENSG00000060762 or ENSG00000143158 or ENSG00000155380
-HMR_4964,ENSG00000100075
-r2420,ENSG00000075415
-ATPtm,ENSG00000005022 or ENSG00000151729 or ENSG00000169100
-FUMtm,ENSG00000183048
-CO2tm,
-O2tm,
-r0801,ENSG00000169100
-THD1m,ENSG00000112992
-H2Otm,ENSG00000103375
-NH4tm,
-HCO3E,ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000164879 or ENSG00000167434 or ENSG00000168748 or ENSG00000185015
-HCO3Em,ENSG00000169239 or ENSG00000174990
-GLUN,ENSG00000115419
-GLNS,ENSG00000135821 or ENSG00000146166
-GLUt2m,ENSG00000177542 or ENSG00000182902
-GLNtm_1,
-GLUNm,ENSG00000115419 or ENSG00000135423
-GLUPRT,ENSG00000128059
-PRAGSr,ENSG00000159131
-GARFT,ENSG00000159131
-PRFGS,ENSG00000178921
-PRAIS,ENSG00000159131
-AIRCr,ENSG00000128050
-PRASCSi,ENSG00000128050
-ADSL2r,ENSG00000239900
-AICART,ENSG00000138363
-IMPC,ENSG00000138363
-ADSS,ENSG00000035687 or ENSG00000185100
-ADSL1r,ENSG00000239900
-IMPDH2,ENSG00000106348 or ENSG00000178035
-GMPS,ENSG00000163655
-GMPS2,ENSG00000163655
-GK1,ENSG00000143774
-RNDR2,ENSG00000167325 and (ENSG00000048392 or ENSG00000171848)
-ADK1,ENSG00000004455 or ENSG00000106992 or ENSG00000140057 or ENSG00000154027
-RNDR1,ENSG00000167325 and (ENSG00000048392 or ENSG00000171848)
-CBPS,ENSG00000084774
-ASPCT,ENSG00000084774
-DHORTS,ENSG00000084774
-DHORD9,ENSG00000102967
-ORPT,ENSG00000114491
-OMPDC,ENSG00000114491
-UMPK,ENSG00000162368
-RNDR4,ENSG00000167325 and (ENSG00000048392 or ENSG00000171848)
-TMDS,ENSG00000176890
-URIDK2r,ENSG00000168393
-NDPK2,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-NDPK3,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-CTPS1,ENSG00000047230 or ENSG00000171793
-RNDR3,ENSG00000167325 and (ENSG00000048392 or ENSG00000171848)
-GDHm,ENSG00000148672 or ENSG00000182890
-GLUDym,ENSG00000148672 or ENSG00000182890
-ASPTA,ENSG00000120053
-ASPTAm,ENSG00000125166
-ASPGLUm,ENSG00000004864 or ENSG00000115840
-ASPT,ENSG00000091483
-CBPSam,ENSG00000021826
-OCBTm,ENSG00000036473
-ORNt4m,ENSG00000102743 or ENSG00000120329
-ARGSS,ENSG00000130707
-ARGSL,ENSG00000126522
-ARGN,ENSG00000118520
-ORNDC,ENSG00000115758
-SPMS,ENSG00000116649
-SPRMS,ENSG00000102172 or ENSG00000116649
-ADMDC,ENSG00000123505
-MTAP,ENSG00000099810
-ADPT,ENSG00000198931
-MTRI,
-MDRPD,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-DKMPPD,
-SPMDtex2,
-SPRMti,ENSG00000175003
-GLYAMDTRc,ENSG00000171766
-ARGDr,
-r0074,ENSG00000159423
-GLU5SAtmc,
-G5SADs,ENSG00000159423
-PRO1x,ENSG00000143811
-P5CR,ENSG00000143811
-PROD2,ENSG00000250799
-TransportFAD,
-ASNS1,ENSG00000070669
-ASNN,ENSG00000162174 or ENSG00000166183
-METS,ENSG00000116984
-METAT,ENSG00000151224 or (ENSG00000038274 and ENSG00000168906)
-HMR_3915,ENSG00000150540
-AHCi,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-ADNK1,ENSG00000156110
-CYSTS,ENSG00000160200
-CYSTGL,ENSG00000116761
-MTHFR3,ENSG00000177000
-UNK2,
-UNK3,
-5MTHFt,ENSG00000110195 or ENSG00000110203
-ILETA,ENSG00000060982
-3MOPt2im,
-ILETAm,ENSG00000105552
-LEUTA,ENSG00000060982
-4MOPt2im,
-LEUTAm,ENSG00000105552
-OIVD1m,ENSG00000083123 and ENSG00000091140 and ENSG00000137992 and ENSG00000248098
-ACOAD8m,ENSG00000128928
-MCCCrm,ENSG00000078070 and ENSG00000131844
-MGCHrm,ENSG00000148090
-HMGCOAtm,
-VALTA,ENSG00000060982
-3MOBt2im,
-VALTAim,ENSG00000105552
-OIVD2m,ENSG00000083123 and ENSG00000091140 and ENSG00000137992 and ENSG00000248098
-ACOAD9m,ENSG00000117054 or ENSG00000151498
-ECOAH12m,ENSG00000127884 or (ENSG00000084754 and ENSG00000138029)
-3HBCOAHLm,
-HIBDm,ENSG00000106049
-r0643,ENSG00000072210 or ENSG00000111275 or ENSG00000137124 or ENSG00000143149 or ENSG00000164904
-MMSAD1m,ENSG00000119711
-MMTSADm,
-PCC,
-MMALH,
-MMEm,ENSG00000124370
-MMMm,ENSG00000146085
-ILEtmi,
-LEUt5m,
-VALt5m,
-PGCD,ENSG00000092621
-PSERT,ENSG00000135069
-PSP_L,ENSG00000146733
-GHMT2r,ENSG00000176974
-SERD_L,ENSG00000135094 or ENSG00000139410
-ALATA_L,ENSG00000166123 or ENSG00000167701
-r1435,
-GLYtm,
-GHMT2rm,ENSG00000182199
-MLTHFtm,
-r0962,ENSG00000164933
-FORtm,
-r0514,ENSG00000228716
-DHFRim,ENSG00000228716
-FTHFLmi,ENSG00000100714 or ENSG00000120254
-MTHFCm,ENSG00000065911
-MTHFDm,ENSG00000065911 or ENSG00000100714
-FOLR2,ENSG00000228716
-DHFR,ENSG00000228716
-FTHFLi,ENSG00000100714
-FTHFDH,ENSG00000136010 or ENSG00000144908
-MTHFC,ENSG00000100714
-MTHFD,ENSG00000100714 or ENSG00000177000
-MTHFD2i,ENSG00000065911 or ENSG00000163738
-ACACT1r,ENSG00000120437
-HMGCOAS,ENSG00000112972
-HMGCOAR,ENSG00000113161
-MEVK1,ENSG00000110921
-PMEVK,ENSG00000163344
-IPDDI,ENSG00000067064 or ENSG00000148377
-DPMVD,ENSG00000167508
-DMATT,ENSG00000152904
-GRTT,ENSG00000152904
-HMR_1465,ENSG00000079459
-HMR_1467,ENSG00000079459
-SMO,ENSG00000104549
-LNSTLS,ENSG00000160285
-HMR_1477,ENSG00000001630
-HMR_1478,ENSG00000001630
-HMR_1479,ENSG00000001630
-C14STR,ENSG00000143815 or ENSG00000149809
-HMR_1490,ENSG00000052802 or ENSG00000170271
-HMR_1493,ENSG00000052802 or ENSG00000170271
-HMR_1494,ENSG00000052802 or ENSG00000170271
-C3STDH1,ENSG00000147383
-HMR_1495,ENSG00000147383 or ENSG00000183305
-HMR_1500,ENSG00000132196
-HMR_1502,ENSG00000052802 or ENSG00000170271
-HMR_1503,ENSG00000052802 or ENSG00000170271
-HMR_1504,ENSG00000052802 or ENSG00000170271
-HMR_1505,ENSG00000147383
-HMR_1509,ENSG00000132196
-CHLSTI_1,ENSG00000147155
-HMR_1516,ENSG00000109929
-RE2410C,
-DSMSTOLR,ENSG00000116133
-ACCOAC,ENSG00000076555 or ENSG00000278540
-FASN,ENSG00000169710
-MCAT,ENSG00000169710
-AcetoacetylACPsynthesis,ENSG00000169710
-r0691,ENSG00000169710
-r0681,ENSG00000169710
-r0682,ENSG00000169710
-r0760,ENSG00000169710
-r0761,ENSG00000169710
-r0762,ENSG00000169710
-r0763,ENSG00000169710
-r0764,ENSG00000169710
-r0694,ENSG00000169710
-r0695,ENSG00000169710
-r0765,ENSG00000169710
-r0766,ENSG00000169710
-r0692,ENSG00000169710
-r0693,ENSG00000169710
-r0767,ENSG00000169710
-r0768,ENSG00000169710
-r0769,ENSG00000169710
-r0770,ENSG00000169710
-r0712,ENSG00000169710
-r0713,ENSG00000169710
-r0701,ENSG00000169710
-r0702,ENSG00000169710
-r0771,ENSG00000169710
-r0772,ENSG00000169710
-r0696,ENSG00000169710
-r0697,ENSG00000169710
-r0773,ENSG00000169710
-FA160ACPH,ENSG00000152463 or ENSG00000169710
-palmitateActivation,ENSG00000068366 or ENSG00000123983 or ENSG00000151726 or ENSG00000164398
-carnitineAcylTransferaseI,ENSG00000110090 or ENSG00000169169 or ENSG00000205560
-CARN160t_m,ENSG00000178537
-carnitineAcylTransferaseII,ENSG00000157184
-betaOxidation,ENSG00000072778 and ENSG00000084754 and ENSG00000105379 and ENSG00000115361 and ENSG00000117054 and ENSG00000127884 and ENSG00000138029 and ENSG00000140374 and ENSG00000161533 and ENSG00000167315
-Biomass,
-GLCt1,ENSG00000059804 or ENSG00000100170 or ENSG00000100191 or ENSG00000105641 or ENSG00000109667 or ENSG00000115665 or ENSG00000117394 or ENSG00000117834 or ENSG00000133460 or ENSG00000136856 or ENSG00000138074 or ENSG00000140675 or ENSG00000142583 or ENSG00000146411 or ENSG00000148942 or ENSG00000151229 or ENSG00000154025 or ENSG00000158865 or ENSG00000160326 or ENSG00000163581 or ENSG00000173262 or ENSG00000181856 or ENSG00000197241 or ENSG00000197496 or ENSG00000198743 or ENSG00000256870
-O2t,
-gln_L_t,(ENSG00000130876 and ENSG00000168003) or ENSG00000017483 or ENSG00000188338 or (ENSG00000130876 and ENSG00000168003) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000149150 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003) or ENSG00000111371 or ENSG00000268104 or ENSG00000134294 or ENSG00000139209 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234)
-r0963,ENSG00000110195 or ENSG00000110203 or ENSG00000165457
-arg_L_t,ENSG00000268104 or ENSG00000103064 or ENSG00000021488 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003) or ENSG00000139514 or ENSG00000003989 or ENSG00000165349 or ENSG00000103064 or (ENSG00000168003 and ENSG00000155465) or (ENSG00000103064 and ENSG00000168003)
-phe_L_t,ENSG00000134294 or ENSG00000165349 or ENSG00000268104 or ENSG00000003989 or ENSG00000111371 or ENSG00000139514 or ENSG00000139209 or (ENSG00000174358 and (ENSG00000147003 or ENSG00000130234)) or ENSG00000112394 or ENSG00000278550 or ENSG00000149150 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or ENSG00000092068 or (ENSG00000164363 and ENSG00000147003)
-ile_L_t,ENSG00000268104 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000149150 or ENSG00000278550 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-leu_L_t,ENSG00000111371 or ENSG00000165349 or ENSG00000168003 or ENSG00000003989 or ENSG00000139514 or ENSG00000268104 or ENSG00000139209 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000149150 or ENSG00000278550 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or ENSG00000149150 or (ENSG00000164363 and ENSG00000147003)
-val_L_t,ENSG00000268104 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000149150 or ENSG00000278550 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-met_L_t,ENSG00000111371 or ENSG00000268104 or ENSG00000134294 or ENSG00000197375 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000149150 or ENSG00000278550 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-ser_L_t,ENSG00000111371 or ENSG00000268104 or ENSG00000134294 or ENSG00000139209 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000017483 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000123643 or ENSG00000149150 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-gly_t,(ENSG00000130876 and ENSG00000168003) or ENSG00000111371 or ENSG00000268104 or ENSG00000134294 or ENSG00000139209 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000196517 or ENSG00000196517 or (ENSG00000130876 and ENSG00000168003) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000165970 or ENSG00000017483 or (ENSG00000164363 and ENSG00000147003) or ENSG00000186335 or ENSG00000123643
-asn_L_t,ENSG00000111371 or ENSG00000268104 or ENSG00000134294 or ENSG00000139209 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000017483 or ENSG00000188338 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000149150 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-pro_L_t,ENSG00000139209 or ENSG00000111371 or ENSG00000134294 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000011083 or (ENSG00000163817 and ENSG00000147003) or ENSG00000180773 or ENSG00000186335 or ENSG00000123643 or ENSG00000011083
-HDCAt,ENSG00000125166 or ENSG00000130304 or ENSG00000135218 or ENSG00000167114
-GTHRDt2,
-DmLact,ENSG00000100156 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000256870
-UREAt,ENSG00000132874 or ENSG00000141469
-DmBiomass,
-NH4t,
-PTRCtex2,
-GUDACtr2,
-Dm2oxobutyrate,
-H2Ot,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-PHLACHt,
-CO2t,
-DmGSSG,
-glu_L_t,ENSG00000105143 or ENSG00000106688 or ENSG00000079215 or ENSG00000110436 or ENSG00000162383 or ENSG00000188338 or ENSG00000137204 or (ENSG00000164363 and ENSG00000147003)
-ala_L_t,ENSG00000134294 or ENSG00000003989 or ENSG00000268104 or ENSG00000139514 or ENSG00000111371 or ENSG00000139209 or ENSG00000165349 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000017483 or ENSG00000188338 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or ENSG00000115902 or (ENSG00000164363 and ENSG00000147003) or ENSG00000180773 or ENSG00000186335 or ENSG00000123643 or ENSG00000017483
-asp_L_t,ENSG00000105143 or ENSG00000106688 or ENSG00000079215 or ENSG00000110436 or ENSG00000162383 or ENSG00000188338
-ATPM,
-GACMTRc,ENSG00000130005
-CKc_cho,ENSG00000104879 or ENSG00000166165
-CRTNsyn_cho,
-CRTNtr,
-NDPK1,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-NDPK5,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-NDPK8,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-NDPK7,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-DTMPK,ENSG00000168393
-NDPK4,ENSG00000103024 or ENSG00000143156 or ENSG00000172113 or (ENSG00000239672 and ENSG00000243678)
-his_L_t,ENSG00000268104 or ENSG00000134294 or ENSG00000139209 or ENSG00000188338 or ENSG00000103064 or ENSG00000103064 or ENSG00000021488 or ENSG00000017483 or ENSG00000268104 or ENSG00000196517
-PTRCOX1,ENSG00000002726 or ENSG00000131471 or ENSG00000131480
-ABUTD,ENSG00000143149
-r0465_1,ENSG00000172508
-ABUTH,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-GLUDC,ENSG00000136750 or ENSG00000128683
-HISDr,ENSG00000084110
-URCN,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-IZPN,ENSG00000139344
-GluForTx,ENSG00000160282
-FTCD,ENSG00000160282
-NBAHH_ir,ENSG00000103375 or ENSG00000135517 or ENSG00000161798 or ENSG00000167580 or ENSG00000171885 or ENSG00000240583
-r0283,ENSG00000172508
-ASP1DC,ENSG00000128683
-lys_L_t,ENSG00000268104 or ENSG00000197375 or ENSG00000139514 or ENSG00000003989 or ENSG00000139209 or ENSG00000165349 or ENSG00000103064 or ENSG00000103064 or ENSG00000021488 or ENSG00000268104
-LYStm,ENSG00000102743 or ENSG00000120329
-SACCD3m,ENSG00000008311
-r0525,ENSG00000008311
-AASAD3m,
-r0450,ENSG00000109576
-2OXOADOXm,ENSG00000091140 and ENSG00000105953 and ENSG00000110435 and ENSG00000119689
-GLUTCOADHm,ENSG00000105607
-3HBCDm,ENSG00000121310
-HACD1m,ENSG00000138796 or ENSG00000072506 or (ENSG00000084754 and ENSG00000138029)
-HMGCOASm,ENSG00000134240
-cys_L_t,ENSG00000268104 or ENSG00000134294 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000278550 or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or ENSG00000017483 or (ENSG00000164363 and ENSG00000147003)
-CYSO,ENSG00000129596
-3SALATAi,ENSG00000120053
-3SALAASPm,ENSG00000004864 or ENSG00000115840
-3SALATAim,ENSG00000125166
-3SPYRSP,
-3SPYRSPm,
-HMR_3951,
-ExSulfitem,
-tyr_L_t,ENSG00000112394 or ENSG00000268104 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or (ENSG00000164363 and ENSG00000147003)
-TYRTA,ENSG00000120053 or ENSG00000198650
-34HPPOR,ENSG00000158104
-HGNTOR,ENSG00000113924
-MACACI,ENSG00000100577
-FUMAC,ENSG00000103876
-AACOAT,ENSG00000081760
-thr_L_t,ENSG00000268104 or ENSG00000111371 or ENSG00000134294 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000149150 or ENSG00000268104
-THRD_L,ENSG00000135094 or ENSG00000139410
-OBDHc,
-PPCOAtm,
-trp_L_t,ENSG00000268104 or (ENSG00000174358 and ENSG00000147003) or (ENSG00000174358 and ENSG00000130234) or ENSG00000103257 or ENSG00000103064 or ENSG00000103064 or ENSG00000103064 or ENSG00000268104 or ENSG00000103257 or (ENSG00000164363 and ENSG00000147003) or ENSG00000180773 or ENSG00000112394
-TRPO2,ENSG00000131203 or ENSG00000188676 or ENSG00000151790
-FKYNH,ENSG00000183077
-KYN,ENSG00000115919
-ANTHte,
-KYN3OX,ENSG00000117009
-HKYNH,ENSG00000115919
-3HAO,ENSG00000162882
-PCLAD,ENSG00000153086
-AM6SAD,
-AMCOXO,
-2OXOADPTm,ENSG00000183032
-CystinePyruvate,
-r0027,ENSG00000184470 or ENSG00000198431
-HMR_3996,
-CYSGLTH,
-ACACT1m,ENSG00000075239 or (ENSG00000084754 and ENSG00000138029)
-G3PD1ir,ENSG00000167588
-GLYC3Ptm,
-G3PDm,
-DHAPtm,
-Transport_ala_B_c_e,
-EX_ala_B_e,
-TMDK1,ENSG00000166548 or ENSG00000167900
-THYMDt1,ENSG00000112759 or ENSG00000174669
-EX_thymd_e,
-Transport_HC00576_c_e,
-EX_HC00576_e,
-Transport_4abut_c_e,
-EX_4abut_e,
-GLUVESSEC,ENSG00000091664 or ENSG00000179520 or ENSG00000104888
-EX_chsterol_e,
-r1050,
-EX_gal_e,
-GALt1r,ENSG00000136856 or ENSG00000117394 or ENSG00000059804 or ENSG00000163581 or ENSG00000197496
-GALK,ENSG00000108479 or ENSG00000156958
-UGLT,ENSG00000213930
-PGMT,ENSG00000079739 or ENSG00000169299
-UDPG4E,ENSG00000117308
-t_Lcystin_ala__L,ENSG00000021488 and ENSG00000138079
-t_Lcystin_glu__L,ENSG00000151012 and ENSG00000168003
-t_Lcystin_leu__L,ENSG00000021488 and ENSG00000138079
-t_Lcystin_ser__L,ENSG00000138079 and ENSG00000021488

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/local/desktop.ini	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,6 +0,0 @@
-[.ShellClassInfo]
-IconResource=C:\WINDOWS\System32\SHELL32.dll,4
-[ViewState]
-Mode=
-Vid=
-FolderType=Generic

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/local/medium/medium.csv	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,35 +0,0 @@
-engro2_name,RPMI 1640,DMEM,EMEM,DMEM:F12 = 1:1,McCoy's 5A,IMDM,MEM,GMEM,Leibovitz's L-15,F12,F10,AMEM,Waymouth MB 7521 medium,F12K,William's E Medium,Medium 199,MCDB 105,NEAA,RPMI:F12 = 1:1,RPMI:MEM = 1:1,RPMI:EMEM = 1:1,EMEM:F12 = 1:1,DMEM:RPMI = 2:1,DMEM:IMDM = 1:1,MCDB 105:Medium 199 = 1:1,allOpen
-EX_Lcystin_e,0.20766774,0.20127796,0.09904154,0.09996805,0.0,0.29201278,0.09904154,0.09904154,0.0,0.0,0.0,0.09904154,0.0625,0.0,0.08329073,0.108333334,0.0,0.0,0.10383387,0.15335464,0.15335464,0.04952077,0.20340788666666665,0.24664537000000003,0.054166667,1000
-EX_ala__L_e,0.0,0.0,0.0,0.049999997,0.15617977,0.28089887,0.0,0.0,2.52809,0.099999994,0.101123594,0.28089887,0.0,0.20224719,1.011236,0.28089887,0.030337078,10.0,0.049999997,0.0,0.0,0.049999997,0.0,0.140449435,0.15561797400000002,1000
-EX_arg__L_e,1.1494253,0.39810428,0.5971564,0.69905216,0.19952606,0.39810428,0.5971564,0.19905214,2.8735633,1.0,1.0,0.49763033,0.35545024,2.0,0.28735632,0.33175355,0.29952607,0.0,1.07471265,0.8732908500000001,0.8732908500000001,0.7985782,0.64854462,0.39810428,0.31563980999999997,1000
-EX_asn__L_e,0.37878788,0.0,0.0,0.05,0.3409091,0.18939394,0.0,0.0,1.8939394,0.10006667,0.1,0.33333334,0.0,0.2,0.13333334,0.0,0.1,10.0,0.239427275,0.18939394,0.18939394,0.050033335,0.12626262666666668,0.09469697,0.05,1000
-EX_asp__L_e,0.15037593,0.0,0.0,0.05,0.15015037,0.22556391,0.0,0.0,0.0,0.1,0.09774436,0.22556391,0.45112783,0.2,0.22556391,0.22556391,0.1,10.0,0.125187965,0.075187965,0.075187965,0.05,0.05012531,0.112781955,0.162781955,1000
-EX_chsterol_e,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.00051679584,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.00025839792,1000
-EX_cys__L_e,0.0,0.0,0.0,0.09977272,0.2603306,0.0,0.0,0.0,0.9917355,0.19954544,0.20661157,0.5681818,0.5041322,0.39772728,0.3305785,0.0005681818,0.0,0.0,0.09977272,0.0,0.0,0.09977272,0.0,0.0,0.0002840909,1000
-EX_fol_e,0.0022675737,0.009070295,0.0022675737,0.0060090707,0.022675738,0.009070295,0.0022675737,0.0045351475,0.0022675737,0.0029478457,0.0029478457,0.0022675737,0.0011337869,0.0029478457,0.0022675737,2.2675737e-05,0.001171875,0.0,0.0026077097,0.0022675737,0.0022675737,0.0026077097,0.006802721233333334,0.009070295,0.0005972753685,1000
-EX_gal_e,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,5.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,1000
-EX_glc__D_e,11.111111,25.0,5.5555553,17.505556,16.666666,25.0,5.5555553,25.0,0.0,10.011111,6.111111,5.5555553,27.777779,7.0,11.111111,5.5555553,5.5555553,0.0,10.561111,8.33333315,8.33333315,7.78333315,20.370370333333334,25.0,5.5555553,1000
-EX_gln__L_e,2.0547945,3.9726028,2.0,2.5,1.5013698,4.0,2.0,2.0,2.0547945,1.0,1.0,2.0,2.3972602,2.0,0.0,0.6849315,0.0,0.0,1.52739725,2.02739725,2.02739725,1.5,3.333333366666667,3.9863014000000003,0.34246575,1000
-EX_glu__L_e,0.13605443,0.0,0.0,0.05,0.15034014,0.5102041,0.0,0.0,0.0,0.1,0.1,0.5102041,1.0204082,0.19727892,0.34013605,0.5102041,0.029931974,10.0,0.118027215,0.068027215,0.068027215,0.05,0.04535147666666667,0.25510205,0.27006803700000004,1000
-EX_gly_e,0.13333334,0.4,0.0,0.25,0.1,0.4,0.0,0.0,2.6666667,0.1,0.1,0.6666667,0.6666667,0.2,0.6666667,0.6666667,0.030666666,10.0,0.11666667,0.06666667,0.06666667,0.05,0.31111111333333336,0.4,0.348666683,1000
-EX_gthrd_e,0.0032573289,0.0,0.0,0.0,0.0016286644,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.048859935,0.0,0.00016286645,0.00016286645,0.0,0.0,0.00162866445,0.00162866445,0.00162866445,0.0,0.0010857763,0.0,8.1433225e-05,1000
-EX_hdca_e,0.0,0.0,0.0,0.00014999999,0.0,0.0,0.0,0.0,0.0,0.00029999999,0.0,0.0,0.0,0.0,0.00010169491,0.0,0.0,0.0,0.000149999995,0.0,0.0,0.000149999995,0.0,0.0,0.0,1000
-EX_his__L_e,0.09677419,0.2,0.2,0.14990476,0.09980952,0.2,0.2,0.1,1.6129032,0.1,0.10952381,0.2,0.82580644,0.21809523,0.09677419,0.10419047,0.2,0.0,0.09838709500000001,0.148387095,0.148387095,0.15000000000000002,0.16559139666666667,0.2,0.152095235,1000
-EX_ile__L_e,0.3816794,0.8015267,0.39694658,0.41580153,0.300458,0.8015267,0.39694658,0.39694658,1.908397,0.030534351,0.019847328,0.4,0.1908397,0.060152672,0.3816794,0.3053435,0.5038168,0.0,0.2061068755,0.38931298999999997,0.38931298999999997,0.2137404655,0.6615776000000001,0.8015267,0.40458014999999997,1000
-EX_leu__L_e,0.3816794,0.8015267,0.39694658,0.45076334,0.300458,0.8015267,0.39694658,0.39694658,0.9541985,0.1,0.099236645,0.39694658,0.3816794,0.2,0.57251906,0.45801526,1.0,0.0,0.2408397,0.38931298999999997,0.38931298999999997,0.24847329,0.6615776000000001,0.8015267,0.72900763,1000
-EX_lys__L_e,0.2739726,0.7978142,0.3989071,0.4986339,0.19945355,0.7978142,0.3989071,0.3989071,0.51369864,0.19945355,0.15846995,0.3989071,1.3114754,0.3989071,0.47792348,0.38251367,0.9945355,0.0,0.236713075,0.33643985,0.33643985,0.299180325,0.6232003333333334,0.7978142,0.688524585,1000
-EX_met__L_e,0.10067114,0.20134228,0.10067114,0.11570469,0.099999994,0.20134228,0.10067114,0.10067114,0.5033557,0.030201342,0.030201342,0.10067114,0.33557048,0.06013423,0.10067114,0.10067114,0.10067114,0.0,0.065436241,0.10067114,0.10067114,0.065436241,0.16778523333333337,0.20134228,0.10067114,1000
-EX_phe__L_e,0.09090909,0.4,0.19393939,0.2150303,0.1,0.4,0.19393939,0.2,0.75757575,0.030303031,0.030303031,0.19393939,0.3030303,0.060121212,0.15151516,0.15151516,0.2,0.0,0.0606060605,0.14242423999999998,0.14242423999999998,0.1121212105,0.29696969666666667,0.4,0.17575758000000002,1000
-EX_pi_e,5.633803,0.91558444,1.0144928,0.9530394099999999,4.2028985,0.9057971,1.0144928,0.89855075,1.77920467,1.0,1.6926885,1.0144928,2.7001757,1.23784074,1.0144928,1.0144928,0.5,0.0,3.3169015,3.3241479000000003,3.3241479000000003,1.0072464,2.4883239600000002,0.91069077,0.7572464,1000
-EX_pro__L_e,0.17391305,0.0,0.0,0.15,0.15043478,0.3478261,0.0,0.0,0.0,0.3,0.1,0.3478261,0.4347826,0.6,0.26086956,0.3478261,0.1,10.0,0.236956525,0.086956525,0.086956525,0.15,0.05797101666666667,0.17391305,0.22391305,1000
-EX_ptrc_e,0.0,0.0,0.0,0.0005031056,0.0,0.0,0.0,0.0,0.0,0.001,0.0,0.0,0.0,0.0019875776,0.0,0.0,1.242236e-06,0.0,0.0005,0.0,0.0,0.0005,0.0,0.0,6.21118e-07,1000
-EX_pyr_e,0.0,0.0,0.0,0.5,0.0,1.0,0.0,0.0,5.0,1.0,1.0,1.0,0.0,2.0,0.22727273,0.0,1.0,0.0,0.5,0.0,0.0,0.5,0.0,0.5,0.5,1000
-EX_ser__L_e,0.2857143,0.4,0.0,0.25,0.25047618,0.4,0.0,0.0,1.9047619,0.1,0.1,0.23809524,0.0,0.2,0.0952381,0.23809524,0.30476192,10.0,0.19285714999999998,0.14285715,0.14285715,0.05,0.36190476666666666,0.4,0.27142858000000003,1000
-EX_thr__L_e,0.16806723,0.79831934,0.40336135,0.44915968,0.15042016,0.79831934,0.40336135,0.39999998,2.5210085,0.099999994,0.0302521,0.40336135,0.6302521,0.19327731,0.33613446,0.25210086,0.10084034,0.0,0.134033612,0.28571429000000004,0.28571429000000004,0.251680672,0.5882353033333333,0.79831934,0.17647059999999998,1000
-EX_thymd_e,0.0,0.0,0.0,0.0015082645,0.0,0.0,0.0,0.0,0.0,0.002892562,0.002892562,0.041322313,0.0,0.002892562,0.0,0.0,9.917356e-05,0.0,0.001446281,0.0,0.0,0.001446281,0.0,0.0,4.958678e-05,1000
-EX_trp__L_e,0.024509804,0.078431375,0.04901961,0.04421569,0.0151960775,0.078431375,0.04901961,0.039215688,0.09803922,0.01,0.0029411765,0.04901961,0.19607843,0.020098038,0.04901961,0.04901961,0.020098038,0.0,0.017254902,0.036764707,0.036764707,0.029509805,0.060457517999999995,0.078431375,0.034558824,1000
-EX_tyr__L_e,0.11111111,0.39779004,0.19923371,0.21375479,0.1,0.46222222,0.19923371,0.19923371,1.6574585,0.02980916,0.010038313,0.23111111,0.22099447,0.051526718,0.19406131,0.22222222,0.1,0.0,0.07046013500000001,0.15517241,0.15517241,0.114521435,0.3022303966666667,0.43000613,0.16111111,1000
-EX_val__L_e,0.17094018,0.8034188,0.3931624,0.4517094,0.15042736,0.8034188,0.3931624,0.4,0.85470086,0.1,0.02991453,0.3931624,0.5555556,0.1965812,0.42735043,0.21367522,1.0,0.0,0.13547009,0.28205129,0.28205129,0.2465812,0.5925925933333334,0.8034188,0.60683761,1000
-EX_o2_e,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,0.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000
-EX_h_e,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,0.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000
-EX_h2o_e,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,0.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000.0,1000

--- a/cobraxy-9688ad27287b/COBRAxy/utils/cobraxy-9688ad27287b/COBRAxy/local/models/ENGRO2.xml	Sun Oct 13 11:38:28 2024 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,11558 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" metaid="meta_" sboTerm="SBO:0000624" level="3" version="1" fbc:required="false">
-  <model metaid="meta_dc" id="dc" name="Empty model structure" fbc:strict="true">
-    <listOfUnitDefinitions>
-      <unitDefinition id="mmol_per_gDW_per_hr">
-        <listOfUnits>
-          <unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
-          <unit kind="gram" exponent="-1" scale="0" multiplier="1"/>
-          <unit kind="second" exponent="-1" scale="0" multiplier="3600"/>
-        </listOfUnits>
-      </unitDefinition>
-    </listOfUnitDefinitions>
-    <listOfCompartments>
-      <compartment id="C_c" name="cytosol" constant="true"/>
-      <compartment id="C_m" name="mitochondrium" constant="true"/>
-      <compartment id="C_e" name="extracellular" constant="true"/>
-    </listOfCompartments>
-    <listOfSpecies>
-      <species metaid="meta_M_accoa_c" sboTerm="SBO:0000299" id="M_accoa_c" name="acetylCoAc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C23H34N7O17P3S"/>
-      <species metaid="meta_M_accoa_m" sboTerm="SBO:0000299" id="M_accoa_m" name="acetylCoAm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C23H34N7O17P3S"/>
-      <species metaid="meta_M_pyr_m" sboTerm="SBO:0000299" id="M_pyr_m" name="pyruvatem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H3O3"/>
-      <species metaid="meta_M_pyr_c" sboTerm="SBO:0000299" id="M_pyr_c" name="pyruvatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H3O3"/>
-      <species metaid="meta_M_lac__L_c" sboTerm="SBO:0000299" id="M_lac__L_c" name="lactatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H5O3"/>
-      <species metaid="meta_M_lac__L_e" sboTerm="SBO:0000299" id="M_lac__L_e" name="lactatex" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H5O3"/>
-      <species metaid="meta_M_f6p_c" sboTerm="SBO:0000299" id="M_f6p_c" name="fructose6phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H11O9P"/>
-      <species metaid="meta_M_fdp_c" sboTerm="SBO:0000299" id="M_fdp_c" name="fructose1_6bisphosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H10O12P2"/>
-      <species metaid="meta_M_pep_c" sboTerm="SBO:0000299" id="M_pep_c" name="PEPc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H2O6P"/>
-      <species metaid="meta_M_2pg_c" sboTerm="SBO:0000299" id="M_2pg_c" name="2phosphoDglyceratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H4O7P"/>
-      <species metaid="meta_M_13dpg_c" sboTerm="SBO:0000299" id="M_13dpg_c" name="1_3bisphosphoDglyceratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H4O10P2"/>
-      <species metaid="meta_M_23dpg_c" sboTerm="SBO:0000299" id="M_23dpg_c" name="2_3bisphosphoDglyceratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H3O10P2"/>
-      <species metaid="meta_M_g3p_c" sboTerm="SBO:0000299" id="M_g3p_c" name="GAPc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H5O6P"/>
-      <species metaid="meta_M_dhap_c" sboTerm="SBO:0000299" id="M_dhap_c" name="DHAPc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H5O6P"/>
-      <species metaid="meta_M_g6p_c" sboTerm="SBO:0000299" id="M_g6p_c" name="glucose6phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H11O9P"/>
-      <species metaid="meta_M_glc__D_c" sboTerm="SBO:0000299" id="M_glc__D_c" name="glucosec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H12O6"/>
-      <species metaid="meta_M_glc__D_e" sboTerm="SBO:0000299" id="M_glc__D_e" name="glucosex" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H12O6"/>
-      <species metaid="meta_M_3pg_c" sboTerm="SBO:0000299" id="M_3pg_c" name="3phosphoDglyceratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H4O7P"/>
-      <species metaid="meta_M_ficytC_m" sboTerm="SBO:0000299" id="M_ficytC_m" name="ferricytochromeCm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C42H54FeN8O6S2"/>
-      <species metaid="meta_M_focytC_m" sboTerm="SBO:0000299" id="M_focytC_m" name="ferrocytochromeCm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C42H54FeN8O6S2"/>
-      <species metaid="meta_M_mal__L_c" sboTerm="SBO:0000299" id="M_mal__L_c" name="malatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H4O5"/>
-      <species metaid="meta_M_mal__L_m" sboTerm="SBO:0000299" id="M_mal__L_m" name="malatem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H4O5"/>
-      <species metaid="meta_M_oaa_c" sboTerm="SBO:0000299" id="M_oaa_c" name="OAAc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H2O5"/>
-      <species metaid="meta_M_oaa_m" sboTerm="SBO:0000299" id="M_oaa_m" name="OAAm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H2O5"/>
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-      <species metaid="meta_M_q10h2_m" sboTerm="SBO:0000299" id="M_q10h2_m" name="ubiquinolm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C59H92O4"/>
-      <species metaid="meta_M_succoa_m" sboTerm="SBO:0000299" id="M_succoa_m" name="succinylCoAm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C25H35N7O19P3S"/>
-      <species metaid="meta_M_succ_m" sboTerm="SBO:0000299" id="M_succ_m" name="succinatem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H4O4"/>
-      <species metaid="meta_M_icit_c" sboTerm="SBO:0000299" id="M_icit_c" name="isocitratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H5O7"/>
-      <species metaid="meta_M_icit_m" sboTerm="SBO:0000299" id="M_icit_m" name="isocitratem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H5O7"/>
-      <species metaid="meta_M_akg_c" sboTerm="SBO:0000299" id="M_akg_c" name="AKGc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H4O5"/>
-      <species metaid="meta_M_akg_m" sboTerm="SBO:0000299" id="M_akg_m" name="AKGm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H4O5"/>
-      <species metaid="meta_M_cit_c" sboTerm="SBO:0000299" id="M_cit_c" name="citratec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H5O7"/>
-      <species metaid="meta_M_cit_m" sboTerm="SBO:0000299" id="M_cit_m" name="citratem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H5O7"/>
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-      <species metaid="meta_M_fum_m" sboTerm="SBO:0000299" id="M_fum_m" name="fumaratem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H2O4"/>
-      <species metaid="meta_M_6pgl_c" sboTerm="SBO:0000299" id="M_6pgl_c" name="glucono1_5lactone6phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H9O9P"/>
-      <species metaid="meta_M_r5p_c" sboTerm="SBO:0000299" id="M_r5p_c" name="ribose5phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H9O8P"/>
-      <species metaid="meta_M_ru5p__D_c" sboTerm="SBO:0000299" id="M_ru5p__D_c" name="ribulose5phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H9O8P"/>
-      <species metaid="meta_M_xu5p__D_c" sboTerm="SBO:0000299" id="M_xu5p__D_c" name="Dxylulose5phosphatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H9O8P"/>
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-      <species metaid="meta_M_6pgc_c" sboTerm="SBO:0000299" id="M_6pgc_c" name="6phosphoDgluconatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H10O10P"/>
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-      <species metaid="meta_M_glu__L_c" sboTerm="SBO:0000299" id="M_glu__L_c" name="glutamatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H8NO4"/>
-      <species metaid="meta_M_glu__L_m" sboTerm="SBO:0000299" id="M_glu__L_m" name="glutamatem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H8NO4"/>
-      <species metaid="meta_M_glu__L_e" sboTerm="SBO:0000299" id="M_glu__L_e" name="glutamatex" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H8NO4"/>
-      <species metaid="meta_M_gln__L_c" sboTerm="SBO:0000299" id="M_gln__L_c" name="glutaminec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"/>
-      <species metaid="meta_M_gln__L_e" sboTerm="SBO:0000299" id="M_gln__L_e" name="glutaminex" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"/>
-      <species metaid="meta_M_gln__L_m" sboTerm="SBO:0000299" id="M_gln__L_m" name="glutaminem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"/>
-      <species metaid="meta_M_asp__L_c" sboTerm="SBO:0000299" id="M_asp__L_c" name="aspartatec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H6NO4"/>
-      <species metaid="meta_M_asp__L_m" sboTerm="SBO:0000299" id="M_asp__L_m" name="aspartatem" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H6NO4"/>
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-      <species metaid="meta_M_Lcystin_c" sboTerm="SBO:0000299" id="M_Lcystin_c" name="cystinec" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species metaid="meta_M_glyc3p_c" sboTerm="SBO:0000299" id="M_glyc3p_c" name="glycerol3Pc" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H7O6P"/>
-      <species metaid="meta_M_glyc3p_m" sboTerm="SBO:0000299" id="M_glyc3p_m" name="glycerol3Pm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H7O6P"/>
-      <species metaid="meta_M_dhap_m" sboTerm="SBO:0000299" id="M_dhap_m" name="DHAPm" compartment="C_m" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C3H5O6P"/>
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-      <species metaid="meta_M_mev__R_c" sboTerm="SBO:0000299" id="M_mev__R_c" name="RMevalonate" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H11O4"/>
-      <species metaid="meta_M_5pmev_c" sboTerm="SBO:0000299" id="M_5pmev_c" name="R_5_Phosphomevalonate" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H10O7P"/>
-      <species metaid="meta_M_5dpmev_c" sboTerm="SBO:0000299" id="M_5dpmev_c" name="R_5_Diphosphomevalonate" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H10O10P2"/>
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-      <species metaid="meta_M_sql_c" sboTerm="SBO:0000299" id="M_sql_c" name="Squalene" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C30H50"/>
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-      <species metaid="meta_M_lanost_c" sboTerm="SBO:0000299" id="M_lanost_c" name="Lanosterol" compartment="C_c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C30H50O"/>
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-      <species metaid="meta_M_thymd_e" sboTerm="SBO:0000299" id="M_thymd_e" name="Thymidine" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0"/>
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-      <species id="M_chsterol_e" name="Cholesterol" compartment="C_e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:chemicalFormula="C27H46O"/>
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-    </listOfSpecies>
-    <listOfParameters>
-      <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-1000" constant="true"/>
-      <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="1000" constant="true"/>
-      <parameter sboTerm="SBO:0000626" id="cobra_0_bound" value="0" constant="true"/>
-      <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/>
-      <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/>
-    </listOfParameters>
-    <listOfReactions>
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-        <listOfReactants>
-          <speciesReference species="M_lac__L_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction metaid="meta_R_EX_glc__D_e" sboTerm="SBO:0000627" id="R_EX_glc__D_e" name="EX_glucosex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction metaid="meta_R_EX_glu__L_e" sboTerm="SBO:0000627" id="R_EX_glu__L_e" name="EX_glutamateINx" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction metaid="meta_R_EX_gln__L_e" sboTerm="SBO:0000627" id="R_EX_gln__L_e" name="EX_glutaminex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gln__L_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction metaid="meta_R_EX_asp__L_e" sboTerm="SBO:0000627" id="R_EX_asp__L_e" name="EX_aspartatex" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_asp__L_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction metaid="meta_R_EX_co2_e" sboTerm="SBO:0000627" id="R_EX_co2_e" name="EX_CO2x" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-      <reaction metaid="meta_R_EX_h2o_e" sboTerm="SBO:0000627" id="R_EX_h2o_e" name="EX_H2Ox" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-      <reaction metaid="meta_R_EX_pi_e" sboTerm="SBO:0000627" id="R_EX_pi_e" name="EX_Pix" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
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-      </reaction>
-      <reaction metaid="meta_R_EX_nh4_e" sboTerm="SBO:0000627" id="R_EX_nh4_e" name="EX_NH3x" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-      </reaction>
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-      </reaction>
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-      </reaction>
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-      </reaction>
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-      </reaction>
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-      <reaction metaid="meta_R_PYRt2" sboTerm="SBO:0000176" id="R_PYRt2" name="Pyruvate transport in via proton symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-      <reaction metaid="meta_R_FBA" sboTerm="SBO:0000176" id="R_FBA" name="FBPALDO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_TPI" sboTerm="SBO:0000176" id="R_TPI" name="TPI" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
-          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_GAPD" sboTerm="SBO:0000176" id="R_GAPD" name="GAPDH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4141"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PGK" sboTerm="SBO:0000176" id="R_PGK" name="PGK" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8898"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_DPGM" sboTerm="SBO:0000176" id="R_DPGM" name="13BPGM" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_23dpg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8888"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1093"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_DPGase" sboTerm="SBO:0000176" id="R_DPGase" name="23BPGM" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_23dpg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8888"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1093"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PGM" sboTerm="SBO:0000176" id="R_PGM" name="PGM_1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8888"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1093"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ENO" sboTerm="SBO:0000176" id="R_ENO" name="ENO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3353"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PYK" sboTerm="SBO:0000176" id="R_PYK" name="PK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
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-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9020"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_LDH_L" sboTerm="SBO:0000176" id="R_LDH_L" name="LDH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_lac__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__21481"/>
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-      </reaction>
-      <reaction metaid="meta_R_r0407" sboTerm="SBO:0000176" id="R_r0407" name="ALDO1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_HC00361_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__414"/>
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-      </reaction>
-      <reaction metaid="meta_R_PRPPS" sboTerm="SBO:0000176" id="R_PRPPS" name="PRPS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9463"/>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfProducts>
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-      </reaction>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-          <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_r0408" sboTerm="SBO:0000176" id="R_r0408" name="SBPase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8877"/>
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-        <listOfReactants>
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-        <listOfProducts>
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-      </reaction>
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-        <fbc:geneProductAssociation>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_CSm" sboTerm="SBO:0000176" id="R_CSm" name="CS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_accoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_oaa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cit_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2422"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACONTm" sboTerm="SBO:0000176" id="R_ACONTm" name="mACO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_cit_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_icit_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__118"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__117"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ICDHxm" sboTerm="SBO:0000176" id="R_ICDHxm" name="IDH3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_icit_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5386"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5385"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5384"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ICDHym" sboTerm="SBO:0000176" id="R_ICDHym" name="IDH2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_icit_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5383"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AKGDm" sboTerm="SBO:0000176" id="R_AKGDm" name="AKGDH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_succoa_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2898"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8124"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2911"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SUCOAS1m" sboTerm="SBO:0000176" id="R_SUCOAS1m" name="SCS" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gdp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_succoa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gtp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_succ_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11449"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11450"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SUCD1m" sboTerm="SBO:0000176" id="R_SUCD1m" name="SDH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_succ_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fum_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10680"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10681"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10682"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10683"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_FUMm" sboTerm="SBO:0000176" id="R_FUMm" name="FH1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fum_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_mal__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3700"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MDHm" sboTerm="SBO:0000176" id="R_MDHm" name="MDH2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_mal__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_oaa_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6971"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ME1m" sboTerm="SBO:0000176" id="R_ME1m" name="ME2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_mal__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6984"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ME2m" sboTerm="SBO:0000176" id="R_ME2m" name="ME3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_mal__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6985"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ME2" sboTerm="SBO:0000176" id="R_ME2" name="ME1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6983"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACITL" sboTerm="SBO:0000176" id="R_ACITL" name="ACLY" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__115"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_FUM" sboTerm="SBO:0000176" id="R_FUM" name="FH2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3700"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MDH" sboTerm="SBO:0000176" id="R_MDH" name="MDH1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6970"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__17836"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AKGMALtm" sboTerm="SBO:0000176" id="R_AKGMALtm" name="SLC25A11" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_mal__L_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10981"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10980"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACONT" sboTerm="SBO:0000176" id="R_ACONT" name="cACO" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__117"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ICDHyr" sboTerm="SBO:0000176" id="R_ICDHyr" name="IDH1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5382"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PPA" sboTerm="SBO:0000176" id="R_PPA" name="cPPA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__30042"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9226"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_Complex1ROS" sboTerm="SBO:0000176" id="R_Complex1ROS" name="Complex1ROS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_m" stoichiometry="4.75" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2_m" stoichiometry="0.05" constant="true"/>
-          <speciesReference species="M_q10_m" stoichiometry="0.95" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="3.8" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2s_m" stoichiometry="0.05" constant="true"/>
-          <speciesReference species="M_q10h2_m" stoichiometry="0.95" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7694"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7707"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7699"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7697"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7702"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7705"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7715"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7714"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7698"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7692"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7683"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7688"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7684"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7685"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7700"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7693"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7696"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20372"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7704"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7706"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7708"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7701"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7703"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7716"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7712"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7686"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20371"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7717"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7695"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7690"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__17194"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7462"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7456"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7461"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7458"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7459"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7455"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7460"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7710"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_FADH2ETC" sboTerm="SBO:0000176" id="R_FADH2ETC" name="Complex2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_q10_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_q10h2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3483"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3482"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3481"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_CYOR_u10mi" sboTerm="SBO:0000176" id="R_CYOR_u10mi" name="Complex3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ficytC_m" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_q10h2_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_q10_m" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__12582"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29594"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__12590"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__30863"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7427"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
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-          <speciesReference species="M_h_m" stoichiometry="8" constant="true"/>
-          <speciesReference species="M_o2_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_m" stoichiometry="2" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2267"/>
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-            <fbc:or>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2287"/>
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-            <fbc:or>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__24380"/>
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-            <fbc:or>
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-            <fbc:or>
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-            <fbc:or>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__24382"/>
-            </fbc:or>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
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-        <listOfReactants>
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__840"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__838"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__823"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__847"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__833"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14247"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__845"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__846"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7414"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7415"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__848"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__850"/>
-            <fbc:or>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__842"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__843"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__841"/>
-            </fbc:or>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLUCYS" sboTerm="SBO:0000176" id="R_GLUCYS" name="GCL" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_glucys_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4312"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GTHS" sboTerm="SBO:0000176" id="R_GTHS" name="GSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glucys_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4624"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SPODMm" sboTerm="SBO:0000176" id="R_SPODMm" name="SOD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_m" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_o2s_m" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h2o2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11180"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GTHPi" sboTerm="SBO:0000176" id="R_GTHPi" name="GPcit" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_h2o2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9353"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4553"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GTHPm" sboTerm="SBO:0000176" id="R_GTHPm" name="GPmit" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gthrd_m" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_h2o2_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_m" stoichiometry="2" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4553"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
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-        <listOfReactants>
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-        <listOfProducts>
-          <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4623"/>
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-      </reaction>
-      <reaction metaid="meta_R_GTHOr" sboTerm="SBO:0000176" id="R_GTHOr" name="cGSRnadph" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4623"/>
-        </fbc:geneProductAssociation>
-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_gthox_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4623"/>
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-      </reaction>
-      <reaction metaid="meta_R_GTHOm" sboTerm="SBO:0000176" id="R_GTHOm" name="mGSRnadph" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4623"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_r0885" sboTerm="SBO:0000176" id="R_r0885" name="TrasportGSH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gthrd_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_gthrd_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10980"/>
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-      </reaction>
-      <reaction metaid="meta_R_PYRt2m" sboTerm="SBO:0000176" id="R_PYRt2m" name="MPC" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_m" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10922"/>
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-      </reaction>
-      <reaction metaid="meta_R_HMR_4964" sboTerm="SBO:0000176" id="R_HMR_4964" name="SLC25A1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_cit_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10979"/>
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-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10992"/>
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-      </reaction>
-      <reaction metaid="meta_R_FUMtm" sboTerm="SBO:0000176" id="R_FUMtm" name="SLC25A10" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10980"/>
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-      </reaction>
-      <reaction metaid="meta_R_CO2tm" sboTerm="SBO:0000176" id="R_CO2tm" name="TransportCO2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
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-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_O2tm" sboTerm="SBO:0000176" id="R_O2tm" name="TransportO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_o2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_r0801" sboTerm="SBO:0000176" id="R_r0801" name="GNT" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gtp_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10992"/>
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-      </reaction>
-      <reaction metaid="meta_R_THD1m" sboTerm="SBO:0000176" id="R_THD1m" name="NNT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nadph_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7863"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_H2Otm" sboTerm="SBO:0000176" id="R_H2Otm" name="AQP8" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__642"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_NH4tm" sboTerm="SBO:0000176" id="R_NH4tm" name="TransportNH3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_nh4_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_HCO3E" sboTerm="SBO:0000176" id="R_HCO3E" name="cCA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hco3_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1371"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1373"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1383"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1372"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1380"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1368"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1374"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1375"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1381"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14914"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HCO3Em" sboTerm="SBO:0000176" id="R_HCO3Em" name="mCA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hco3_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1378"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1377"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLUN" sboTerm="SBO:0000176" id="R_GLUN" name="cGLS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4331"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLNS" sboTerm="SBO:0000176" id="R_GLNS" name="GS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4341"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__21016"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLUt2m" sboTerm="SBO:0000176" id="R_GLUt2m" name="GluCarrier" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__19954"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10988"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLNtm_1" sboTerm="SBO:0000176" id="R_GLNtm_1" name="GlnCarrier" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gln__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_GLUNm" sboTerm="SBO:0000176" id="R_GLUNm" name="mGLS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gln__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4331"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29570"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLUPRT" sboTerm="SBO:0000176" id="R_GLUPRT" name="PPAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pram_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9238"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PRAGSr" sboTerm="SBO:0000176" id="R_PRAGSr" name="GART1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pram_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gar_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4163"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GARFT" sboTerm="SBO:0000176" id="R_GARFT" name="GART2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gar_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_fgam_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4163"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PRFGS" sboTerm="SBO:0000176" id="R_PRFGS" name="PFAS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fgam_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fpram_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8863"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PRAIS" sboTerm="SBO:0000176" id="R_PRAIS" name="GART3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fpram_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4163"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AIRCr" sboTerm="SBO:0000176" id="R_AIRCr" name="PAICS1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_air_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8587"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PRASCSi" sboTerm="SBO:0000176" id="R_PRASCSi" name="PAICS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5aizc_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_25aics_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8587"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADSL2r" sboTerm="SBO:0000176" id="R_ADSL2r" name="PAICS3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_25aics_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__291"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AICART" sboTerm="SBO:0000176" id="R_AICART" name="ATIC1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_aicar_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__794"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_IMPC" sboTerm="SBO:0000176" id="R_IMPC" name="ATIC2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fprica_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__794"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADSS" sboTerm="SBO:0000176" id="R_ADSS" name="ADSS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_dcamp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__292"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20093"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADSL1r" sboTerm="SBO:0000176" id="R_ADSL1r" name="ADSL" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_dcamp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__291"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_IMPDH2" sboTerm="SBO:0000176" id="R_IMPDH2" name="IMPDH2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_imp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6052"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6053"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GMPS" sboTerm="SBO:0000176" id="R_GMPS" name="GMPS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4378"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GMPS2" sboTerm="SBO:0000176" id="R_GMPS2" name="GMPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_xmp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4378"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GK1" sboTerm="SBO:0000176" id="R_GK1" name="GUK1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gmp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4693"/>
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-      </reaction>
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-        <listOfProducts>
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-      </reaction>
-      <reaction metaid="meta_R_ADK1" sboTerm="SBO:0000176" id="R_ADK1" name="cAK" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__365"/>
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-      </reaction>
-      <reaction metaid="meta_R_RNDR1" sboTerm="SBO:0000176" id="R_RNDR1" name="RRM2B2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10452"/>
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-      </reaction>
-      <reaction metaid="meta_R_CBPS" sboTerm="SBO:0000176" id="R_CBPS" name="CAD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1424"/>
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-      </reaction>
-      <reaction metaid="meta_R_ASPCT" sboTerm="SBO:0000176" id="R_ASPCT" name="CAD2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1424"/>
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-      </reaction>
-      <reaction metaid="meta_R_DHORTS" sboTerm="SBO:0000176" id="R_DHORTS" name="CAD3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1424"/>
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-      </reaction>
-      <reaction metaid="meta_R_DHORD9" sboTerm="SBO:0000176" id="R_DHORD9" name="DHODH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_dhor__S_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_q10_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_q10h2_m" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2867"/>
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-      <reaction metaid="meta_R_ORPT" sboTerm="SBO:0000176" id="R_ORPT" name="UMPS1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_orot_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__12563"/>
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-      <reaction metaid="meta_R_OMPDC" sboTerm="SBO:0000176" id="R_OMPDC" name="UMPS2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_orot5p_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_ump_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_RNDR4" sboTerm="SBO:0000176" id="R_RNDR4" name="RRM2B3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10452"/>
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-      </reaction>
-      <reaction metaid="meta_R_TMDS" sboTerm="SBO:0000176" id="R_TMDS" name="TYMS" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__12441"/>
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-      <reaction metaid="meta_R_URIDK2r" sboTerm="SBO:0000176" id="R_URIDK2r" name="CMPK2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-      </reaction>
-      <reaction metaid="meta_R_OCBTm" sboTerm="SBO:0000176" id="R_OCBTm" name="OTC" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_orn_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_citr__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8512"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ORNt4m" sboTerm="SBO:0000176" id="R_ORNt4m" name="ORNT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_orn_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__22921"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ARGSS" sboTerm="SBO:0000176" id="R_ARGSS" name="ASS1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_citr__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_argsuc_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__758"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ARGSL" sboTerm="SBO:0000176" id="R_ARGSL" name="ASL" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__746"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ARGN" sboTerm="SBO:0000176" id="R_ARGN" name="ARG1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_arg__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_urea_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__663"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ORNDC" sboTerm="SBO:0000176" id="R_ORNDC" name="ODC1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ptrc_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8109"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SPMS" sboTerm="SBO:0000176" id="R_SPMS" name="SpermidineSynthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ametam_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ptrc_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mta_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_spmd_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11296"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SPRMS" sboTerm="SBO:0000176" id="R_SPRMS" name="SpermineSynthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ametam_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_spmd_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mta_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_sprm_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11296"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADMDC" sboTerm="SBO:0000176" id="R_ADMDC" name="AMD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ametam_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__457"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTAP" sboTerm="SBO:0000176" id="R_MTAP" name="MTAP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5mta_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_5mdr1p_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7413"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADPT" sboTerm="SBO:0000176" id="R_ADPT" name="APRT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ade_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_prpp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__626"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTRI" sboTerm="SBO:0000176" id="R_MTRI" name="MRI1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5mdr1p_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mdru1p_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_MDRPD" sboTerm="SBO:0000176" id="R_MDRPD" name="MTRUD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5mdru1p_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_dkmpp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__637"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__633"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_DKMPPD" sboTerm="SBO:0000176" id="R_DKMPPD" name="dkmppDegradation" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
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-      </reaction>
-      <reaction metaid="meta_R_SPMDtex2" sboTerm="SBO:0000176" id="R_SPMDtex2" name="DMspermidine" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_spmd_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_SPRMti" sboTerm="SBO:0000176" id="R_SPRMti" name="DMspermine" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10963"/>
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-      </reaction>
-      <reaction metaid="meta_R_GLYAMDTRc" sboTerm="SBO:0000176" id="R_GLYAMDTRc" name="AGAT" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-          <speciesReference species="M_orn_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_ARGDr" sboTerm="SBO:0000176" id="R_ARGDr" name="ARGAH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_r0074" sboTerm="SBO:0000176" id="R_r0074" name="ALDH18A1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__406"/>
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-      </reaction>
-      <reaction metaid="meta_R_GLU5SAtmc" sboTerm="SBO:0000176" id="R_GLU5SAtmc" name="TransportGLU5SA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
-          <speciesReference species="M_glu5sa_c" stoichiometry="1" constant="true"/>
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-      </reaction>
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-        <listOfReactants>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_P5CR" sboTerm="SBO:0000176" id="R_P5CR" name="P5CR2nadph" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_PROD2" sboTerm="SBO:0000176" id="R_PROD2" name="PRODH2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_TransportFAD" sboTerm="SBO:0000176" id="R_TransportFAD" name="TransportFAD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-      <reaction metaid="meta_R_ASNS1" sboTerm="SBO:0000176" id="R_ASNS1" name="ASNS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-        </listOfProducts>
-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_ASNN" sboTerm="SBO:0000176" id="R_ASNN" name="ASRGL1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-      <reaction metaid="meta_R_METS" sboTerm="SBO:0000176" id="R_METS" name="MTR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7468"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_METAT" sboTerm="SBO:0000176" id="R_METAT" name="MAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6903"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6905"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6904"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HMR_3915" sboTerm="SBO:0000176" id="R_HMR_3915" name="HNMT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_amet_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5028"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AHCi" sboTerm="SBO:0000176" id="R_AHCi" name="AHCY" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ahcys_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__642"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7103"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__638"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__634"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__637"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__633"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ADNK1" sboTerm="SBO:0000176" id="R_ADNK1" name="ADK" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_adn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__257"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_CYSTS" sboTerm="SBO:0000176" id="R_CYSTS" name="CBS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_hcys__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cyst__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1550"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_CYSTGL" sboTerm="SBO:0000176" id="R_CYSTGL" name="CTH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_cyst__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2501"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTHFR3" sboTerm="SBO:0000176" id="R_MTHFR3" name="MTHFR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7436"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_UNK2" sboTerm="SBO:0000176" id="R_UNK2" name="MetSynthesis" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2kmb_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_UNK3" sboTerm="SBO:0000176" id="R_UNK3" name="TAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2kmb_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_5MTHFt" sboTerm="SBO:0000176" id="R_5MTHFt" name="Dm5methylTHF" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5mthf_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5mthf_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3791"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3795"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ILETA" sboTerm="SBO:0000176" id="R_ILETA" name="cBCAT1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ile__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__976"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_3MOPt2im" sboTerm="SBO:0000176" id="R_3MOPt2im" name="Transport3mop" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3mop_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mop_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_ILETAm" sboTerm="SBO:0000176" id="R_ILETAm" name="mBCAT1" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ile__L_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mop_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__977"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_LEUTA" sboTerm="SBO:0000176" id="R_LEUTA" name="cBCAT2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_leu__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_4mop_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__976"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_4MOPt2im" sboTerm="SBO:0000176" id="R_4MOPt2im" name="Transport4mop" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_4mop_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_4mop_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_LEUTAm" sboTerm="SBO:0000176" id="R_LEUTAm" name="mBCAT2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_leu__L_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_4mop_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__977"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_OIVD1m" sboTerm="SBO:0000176" id="R_OIVD1m" name="BCKD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_4mop_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ivcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__987"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2898"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2698"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__986"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACOAD8m" sboTerm="SBO:0000176" id="R_ACOAD8m" name="IVD" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ivcoa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mb2coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6186"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MCCCrm" sboTerm="SBO:0000176" id="R_MCCCrm" name="MCC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3mb2coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_atp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hco3_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mgcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_adp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6936"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__6937"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MGCHrm" sboTerm="SBO:0000176" id="R_MGCHrm" name="MGCoAH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3mgcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_hmgcoa_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__890"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HMGCOAtm" sboTerm="SBO:0000176" id="R_HMGCOAtm" name="TransportHMGCoA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_hmgcoa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_hmgcoa_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_VALTA" sboTerm="SBO:0000176" id="R_VALTA" name="cBCAT3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_val__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__976"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_3MOBt2im" sboTerm="SBO:0000176" id="R_3MOBt2im" name="Transport3mob" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3mob_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mob_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_VALTAim" sboTerm="SBO:0000176" id="R_VALTAim" name="mBCAT3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_val__L_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_3mob_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__977"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_OIVD2m" sboTerm="SBO:0000176" id="R_OIVD2m" name="BCKD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3mob_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ibcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__987"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2898"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2698"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__986"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACOAD9m" sboTerm="SBO:0000176" id="R_ACOAD9m" name="ACOAD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ibcoa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_2mp2coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__89"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__87"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ECOAH12m" sboTerm="SBO:0000176" id="R_ECOAH12m" name="ECoAH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_3HBCOAHLm" sboTerm="SBO:0000176" id="R_3HBCOAHLm" name="HIBCH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction metaid="meta_R_HIBDm" sboTerm="SBO:0000176" id="R_HIBDm" name="HIBD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_r0643" sboTerm="SBO:0000176" id="R_r0643" name="HIBADH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__407"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__877"/>
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-      </reaction>
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-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppcoa_m" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7179"/>
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-      </reaction>
-      <reaction metaid="meta_R_MMTSADm" sboTerm="SBO:0000176" id="R_MMTSADm" name="MMAL2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-          <speciesReference species="M_mmcoa__R_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_PCC" sboTerm="SBO:0000176" id="R_PCC" name="PCC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_hco3_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppcoa_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_mmcoa__S_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_m" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction metaid="meta_R_MMALH" sboTerm="SBO:0000176" id="R_MMALH" name="MMALH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-          <speciesReference species="M_mmcoa__S_m" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction metaid="meta_R_MMEm" sboTerm="SBO:0000176" id="R_MMEm" name="MCM1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_MMMm" sboTerm="SBO:0000176" id="R_MMMm" name="MCM2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_ILEtmi" sboTerm="SBO:0000176" id="R_ILEtmi" name="TransportIle" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-      </reaction>
-      <reaction metaid="meta_R_LEUt5m" sboTerm="SBO:0000176" id="R_LEUt5m" name="TransportLeu" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-      <reaction metaid="meta_R_VALt5m" sboTerm="SBO:0000176" id="R_VALt5m" name="TransportVal" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <listOfProducts>
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-        <listOfProducts>
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-        <listOfProducts>
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-        <listOfProducts>
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-      <reaction metaid="meta_R_GLYtm" sboTerm="SBO:0000176" id="R_GLYtm" name="TransportGly" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-      <reaction metaid="meta_R_r0962" sboTerm="SBO:0000176" id="R_r0962" name="Transport_folate" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-      <reaction metaid="meta_R_FORtm" sboTerm="SBO:0000176" id="R_FORtm" name="TransportFormate" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_FTHFLmi" sboTerm="SBO:0000176" id="R_FTHFLmi" name="mMTHFD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
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-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_DHFR" sboTerm="SBO:0000176" id="R_DHFR" name="cDHFR2" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_FTHFLi" sboTerm="SBO:0000176" id="R_FTHFLi" name="cMTHFD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7432"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_FTHFDH" sboTerm="SBO:0000176" id="R_FTHFDH" name="cMTHFD2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3978"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTHFC" sboTerm="SBO:0000176" id="R_MTHFC" name="cMTHFD3" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_10fthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7432"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTHFD" sboTerm="SBO:0000176" id="R_MTHFD" name="cMTHFD4" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7432"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7436"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MTHFD2i" sboTerm="SBO:0000176" id="R_MTHFD2i" name="cMTHFD5" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_mlthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:or>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__31865"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ACACT1r" sboTerm="SBO:0000176" id="R_ACACT1r" name="cACAT" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_accoa_c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__94"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HMGCOAS" sboTerm="SBO:0000176" id="R_HMGCOAS" name="cHMGCS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_aacoa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hmgcoa_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5007"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HMGCOAR" sboTerm="SBO:0000176" id="R_HMGCOAR" name="Hydroxymethylglutaryl CoA reductase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_hmgcoa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="2" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_mev__R_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="2" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5006"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_MEVK1" sboTerm="SBO:0000176" id="R_MEVK1" name="Mevalonate kinase  atp" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_mev__R_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7530"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PMEVK" sboTerm="SBO:0000176" id="R_PMEVK" name="Phosphomevalonate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5pmev_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5dpmev_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9141"/>
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-      </reaction>
-      <reaction metaid="meta_R_IPDDI" sboTerm="SBO:0000176" id="R_IPDDI" name="Isopentenyl-diphosphate D-isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
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-        </listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__23487"/>
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-      </reaction>
-      <reaction metaid="meta_R_DPMVD" sboTerm="SBO:0000176" id="R_DPMVD" name="Diphosphomevalonate decarboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction metaid="meta_R_DMATT" sboTerm="SBO:0000176" id="R_DMATT" name="Dimethylallyltranstransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_GRTT" sboTerm="SBO:0000176" id="R_GRTT" name="Geranyltranstransferase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_ipdp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4249"/>
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-      </reaction>
-      <reaction metaid="meta_R_HMR_1465" sboTerm="SBO:0000176" id="R_HMR_1465" name="Farnesyl-Diphosphate:Farnesyl-Diphosphate Farnesyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_frdp_c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_HC01118_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3629"/>
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-      <reaction metaid="meta_R_HMR_1467" sboTerm="SBO:0000176" id="R_HMR_1467" name="Presqualene-Diphosphate Diphosphate-Lyase (Reducing, Squalene-Forming)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_sql_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_SMO" sboTerm="SBO:0000176" id="R_SMO" name="Squalene monooxygenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_sql_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <listOfReactants>
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-        <listOfProducts>
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-        <fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_HMR_1478" sboTerm="SBO:0000176" id="R_HMR_1478" name="Sterol 14Alpha-Demethylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h2o_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2649"/>
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-        <listOfReactants>
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-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_for_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2649"/>
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-      </reaction>
-      <reaction metaid="meta_R_C14STR" sboTerm="SBO:0000176" id="R_C14STR" name="C 14 sterol reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11863"/>
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-      </reaction>
-      <reaction metaid="meta_R_HMR_1490" sboTerm="SBO:0000176" id="R_HMR_1490" name="Methylsterol Monooxygenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
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-      <reaction metaid="meta_R_betaOxidation" sboTerm="SBO:0000176" id="R_betaOxidation" name="betaOxidation" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_dctp_c" stoichiometry="0.009442" constant="true"/>
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-        <listOfReactants>
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-        <listOfProducts>
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-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000003989 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000268104</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_arg__L_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000112394 or ENSG00000149150 or ENSG00000167703</p>
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-                <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000149150 or ENSG00000167703</p>
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-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000149150 or ENSG00000167703</p>
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-      <reaction metaid="meta_R_val_L_t" sboTerm="SBO:0000176" id="R_val_L_t" name="ExVal" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000149150 or ENSG00000167703</p>
-          </html>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__23087"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__26441"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_met_L_t" sboTerm="SBO:0000176" id="R_met_L_t" name="ExMet" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000149150 or ENSG00000167703</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_met__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_met__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13447"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10969"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9225"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__23087"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__26441"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ser_L_t" sboTerm="SBO:0000176" id="R_ser_L_t" name="ExSer" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000017483 or ENSG00000111371 or ENSG00000123643 or ENSG00000134294 or ENSG00000139209 or ENSG00000149150 or ENSG00000268104 or (ENSG00000130234 and ENSG00000174358) or (ENSG00000147003 and ENSG00000164363) or (ENSG00000147003 and ENSG00000174358)</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ser__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13447"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18070"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18761"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9225"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__26441"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_gly_t" sboTerm="SBO:0000176" id="R_gly_t" name="ExGly" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000017483 or ENSG00000111371 or ENSG00000123643 or ENSG00000134294 or ENSG00000139209 or ENSG00000165970 or ENSG00000186335 or ENSG00000196517 or ENSG00000268104 or (ENSG00000130234 and ENSG00000174358) or (ENSG00000147003 and ENSG00000164363) or (ENSG00000147003 and ENSG00000174358)</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_gly_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gly_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:and>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11026"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13447"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11056"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11056"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11051"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18070"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18762"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18761"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_asn_L_t" sboTerm="SBO:0000176" id="R_asn_L_t" name="ExAsn" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000017483 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000149150 or ENSG00000188338 or ENSG00000268104 or (ENSG00000130234 and ENSG00000174358) or (ENSG00000147003 and ENSG00000164363) or (ENSG00000147003 and ENSG00000174358)</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_asn__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_asn__L_e" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18070"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18044"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__9225"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__26441"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_pro_L_t" sboTerm="SBO:0000176" id="R_pro_L_t" name="ExPro" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000123643 or ENSG00000186335</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_pro__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_pro__L_e" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13447"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11054"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__30927"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__19660"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18762"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18761"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HDCAt" sboTerm="SBO:0000176" id="R_HDCAt" name="ExPalmitate" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_hdca_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_hdca_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10995"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1663"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10998"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GTHRDt2" sboTerm="SBO:0000176" id="R_GTHRDt2" name="ExGSH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
-        <listOfReactants>
-          <speciesReference species="M_gthrd_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gthrd_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_DmLact" sboTerm="SBO:0000176" id="R_DmLact" name="DmLact" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_lac__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_lac__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__16270"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10928"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10924"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10922"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__19119"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_UREAt" sboTerm="SBO:0000176" id="R_UREAt" name="DmUrea" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_urea_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_urea_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10919"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10918"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_DmBiomass" sboTerm="SBO:0000176" id="R_DmBiomass" name="DmBiomass" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_BIOMASSA_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_BIOMASSA_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_NH4t" sboTerm="SBO:0000176" id="R_NH4t" name="ExNH3" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_PTRCtex2" sboTerm="SBO:0000176" id="R_PTRCtex2" name="DmPutrescine" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ptrc_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ptrc_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_GUDACtr2" sboTerm="SBO:0000176" id="R_GUDACtr2" name="ExGA" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gudac_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gudac_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_CE2705t" sboTerm="SBO:0000176" id="R_CE2705t" name="ExDihydrobiopterinc" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_CE2705_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_CE2705_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11003"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11004"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_Dm2oxobutyrate" sboTerm="SBO:0000176" id="R_Dm2oxobutyrate" name="Dm2oxobutyrate" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2obut_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_2obut_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_H2Ot" sboTerm="SBO:0000176" id="R_H2Ot" name="ExH2O" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__642"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7103"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__638"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__634"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__637"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__633"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_PHLACHt" sboTerm="SBO:0000176" id="R_PHLACHt" name="ExH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_CO2t" sboTerm="SBO:0000176" id="R_CO2t" name="ExCO2" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_DmGSSG" sboTerm="SBO:0000176" id="R_DmGSSG" name="DmGSSG" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_gthox_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gthox_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_glu_L_t" sboTerm="SBO:0000176" id="R_glu_L_t" name="DmGlu" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000188338</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10944"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10939"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10941"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10940"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11060"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11057"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13447"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18070"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18044"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18762"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18761"/>
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-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000079215 or ENSG00000105143 or ENSG00000106688 or ENSG00000110436 or ENSG00000162383</p>
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-        <listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10941"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10940"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10945"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18044"/>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
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-        <listOfReactants>
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-          <speciesReference species="M_gudac_c" stoichiometry="1" constant="true"/>
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-          <speciesReference species="M_creat_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfReactants>
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-          <speciesReference species="M_creat_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pcreat_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1991"/>
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-        <listOfReactants>
-          <speciesReference species="M_pcreat_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_crtn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
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-      <reaction metaid="meta_R_CRTNtr" sboTerm="SBO:0000176" id="R_CRTNtr" name="DmCreatinine" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_crtn_e" stoichiometry="1" constant="true"/>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gdp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_gtp_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20567"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7850"/>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dgdp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dgtp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20461"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20567"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7850"/>
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-        </fbc:geneProductAssociation>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dadp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_datp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20461"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20567"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7849"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7850"/>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dcdp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_dctp_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20461"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20567"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7850"/>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dtmp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3061"/>
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-        <listOfReactants>
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-          <speciesReference species="M_dtdp_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_dttp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20461"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__20567"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7850"/>
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-            <p>gpr_old: ENSG00000139209</p>
-          </html>
-        </notes>
-        <listOfReactants>
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-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_his__L_e" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11056"/>
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-        <listOfReactants>
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-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ptrc_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_4abutn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o2_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__550"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__549"/>
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-        <listOfReactants>
-          <speciesReference species="M_4abutn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_4abut_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__412"/>
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-      <reaction metaid="meta_R_r0465_1" sboTerm="SBO:0000176" id="R_r0465_1" name="HisAbutLigase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_his__L_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_HC00576_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-        <listOfReactants>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-          <speciesReference species="M_his__L_c" stoichiometry="1" constant="true"/>
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-        <listOfReactants>
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-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-      <reaction metaid="meta_R_URCN" sboTerm="SBO:0000176" id="R_URCN" name="URCN" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_urcan_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_4izp_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__642"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7103"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__638"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__634"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__637"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__633"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_IZPN" sboTerm="SBO:0000176" id="R_IZPN" name="IZPN" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_4izp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_forglu_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__28577"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GluForTx" sboTerm="SBO:0000176" id="R_GluForTx" name="GluForTx" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_forglu_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_thf_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_5forthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3974"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_FTCD" sboTerm="SBO:0000176" id="R_FTCD" name="FTCD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_5forthf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_methf_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__3974"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_NBAHH_ir" sboTerm="SBO:0000176" id="R_NBAHH_ir" name="NBAHH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_carn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ala_B_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_his__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__642"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__7103"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__638"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__634"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__637"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__633"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_r0283" sboTerm="SBO:0000176" id="R_r0283" name="HisAlaLigase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ala_B_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_his__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_carn_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ppi_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29268"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_ASP1DC" sboTerm="SBO:0000176" id="R_ASP1DC" name="ASP1DC" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ala_B_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4092"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_lys_L_t" sboTerm="SBO:0000176" id="R_lys_L_t" name="ExLys" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000003989 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_lys__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_lys__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10969"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11057"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11060"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14679"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11061"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11067"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_LYStm" sboTerm="SBO:0000176" id="R_LYStm" name="TransportLys" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lys__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lys__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10985"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__22921"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_SACCD3m" sboTerm="SBO:0000176" id="R_SACCD3m" name="SACCD3m" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_lys__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_saccrp__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__17366"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_r0525" sboTerm="SBO:0000176" id="R_r0525" name="SACCRPOX" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_saccrp__L_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_L2aadp6sa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__17366"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AASAD3m" sboTerm="SBO:0000176" id="R_AASAD3m" name="AASAD3m" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_L2aadp6sa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_L2aadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_r0450" sboTerm="SBO:0000176" id="R_r0450" name="AADPTA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_L2aadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_2oxoadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__17929"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_2OXOADOXm" sboTerm="SBO:0000176" id="R_2OXOADOXm" name="OXOADPOR" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2oxoadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glutcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2898"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__8124"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__21350"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__2911"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLUTCOADHm" sboTerm="SBO:0000176" id="R_GLUTCOADHm" name="GLUTCOADHm" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glutcoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_b2coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4189"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_3HBCDm" sboTerm="SBO:0000176" id="R_3HBCDm" name="ECOAH1m" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_b2coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_3hbcoa__R_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__23408"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HACD1m" sboTerm="SBO:0000176" id="R_HACD1m" name="HACD1m" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3hbcoa__R_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_aacoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4799"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4800"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4801"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4803"/>
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-          </fbc:or>
-        </fbc:geneProductAssociation>
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-      <reaction metaid="meta_R_HMGCOASm" sboTerm="SBO:0000176" id="R_HMGCOASm" name="mHMGCS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_aacoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_accoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_hmgcoa_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__5008"/>
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-      </reaction>
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-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>gpr_old: ENSG00000167703</p>
-          </html>
-        </notes>
-        <listOfReactants>
-          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cys__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11047"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13448"/>
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-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__27960"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13557"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__23087"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11063"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11064"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__18070"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__26441"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__29437"/>
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-        <listOfReactants>
-          <speciesReference species="M_cys__L_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_3sala_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__1795"/>
-        </fbc:geneProductAssociation>
-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_3sala_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_3snpyr_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4432"/>
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-      </reaction>
-      <reaction metaid="meta_R_3SALAASPm" sboTerm="SBO:0000176" id="R_3SALAASPm" name="Transport3SALA" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_3sala_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_asp__L_m" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_3sala_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_asp__L_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10983"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__10982"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_3SALATAim" sboTerm="SBO:0000176" id="R_3SALATAim" name="3SALATAm" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_am6sa_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__19288"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_AM6SAD" sboTerm="SBO:0000176" id="R_AM6SAD" name="AM6SADH" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_amuco_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_AMCOXO" sboTerm="SBO:0000176" id="R_AMCOXO" name="AMCOXO" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_2OXOADPTm" sboTerm="SBO:0000176" id="R_2OXOADPTm" name="Transport2Oxoadp" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_2oxoadp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_akg_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_2oxoadp_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__14411"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_CystinePyruvate" sboTerm="SBO:0000176" id="R_CystinePyruvate" name="CystinePyruvate" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_r0027" sboTerm="SBO:0000176" id="R_r0027" name="CystineReductaseNADPH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cys__L_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__12437"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_HMR_3996" sboTerm="SBO:0000176" id="R_HMR_3996" name="CystineReductaseNADH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cys__L_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_CYSGLTH" sboTerm="SBO:0000176" id="R_CYSGLTH" name="CystineGSH" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_gthrd_c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_cys__L_c" stoichiometry="2" constant="true"/>
-          <speciesReference species="M_gthox_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_ACACT1m" sboTerm="SBO:0000176" id="R_ACACT1m" name="mACAT_backward" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_aacoa_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_coa_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_accoa_m" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__93"/>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4801"/>
-              <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4803"/>
-            </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_G3PD1ir" sboTerm="SBO:0000176" id="R_G3PD1ir" name="G3PD1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4455"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="meta_R_GLYC3Ptm" sboTerm="SBO:0000176" id="R_GLYC3Ptm" name="Transport_glycerol3P" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_glyc3p_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_glyc3p_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_G3PDm" sboTerm="SBO:0000176" id="R_G3PDm" name="GLY3PFAD" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_fad_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glyc3p_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_dhap_m" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_fadh2_m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="meta_R_DHAPtm" sboTerm="SBO:0000176" id="R_DHAPtm" name="Transport_DHAP" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_dhap_m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction id="R_Transport_ala_B_c_e" name="Transport_ala_B_c_e" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ala_B_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_ala_B_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction id="R_EX_ala_B_e" name="bAlae ExchangeRxn" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_ala_B_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
-      <reaction id="R_TMDK1" name="TMDK1" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_thymd_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_h_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11830"/>
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-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction id="R_THYMDt1" name="Thymd Transport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_0_bound">
-        <listOfReactants>
-          <speciesReference species="M_thymd_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_thymd_e" stoichiometry="1" constant="true"/>
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-          <fbc:or>
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-        </fbc:geneProductAssociation>
-      </reaction>
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-          <speciesReference species="M_thymd_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_HC00576_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-      </reaction>
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-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_4abut_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
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-        </listOfProducts>
-      </reaction>
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-          <speciesReference species="M_4abut_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_EX_chsterol_e" name="Exchange of Cholesterol" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
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-          <speciesReference species="M_chsterol_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_chsterol_e" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_chsterol_c" stoichiometry="1" constant="true"/>
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-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_gal_e" stoichiometry="1" constant="true"/>
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-      </reaction>
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-        <listOfReactants>
-          <speciesReference species="M_gal_e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_gal_c" stoichiometry="1" constant="true"/>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__13444"/>
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-      </reaction>
-      <reaction id="R_GALK" name="Galactokinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-        <listOfProducts>
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-          <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
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-      </reaction>
-      <reaction id="R_UGLT" name="UDPglucose-Hexose-1-Phosphate Uridylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
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-          <speciesReference species="M_gal1p_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
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-          <speciesReference species="M_udpgal_c" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4135"/>
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-      </reaction>
-      <reaction id="R_PGMT" name="Phosphoglucomutase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_g1p_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/>
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-      </reaction>
-      <reaction id="R_UDPG4E" name="UDPglucose 4-Epimerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_udpg_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_udpgal_c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__4116"/>
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-      </reaction>
-      <reaction id="R_t_Lcystin_ala__L" name="t_Lcystin_ala__L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_e" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ala__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ala__L_e" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:and>
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-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11025"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction id="R_t_Lcystin_glu__L" name="t_Lcystin_glu__L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_e" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11059"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11026"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction id="R_t_Lcystin_leu__L" name="t_Lcystin_leu__L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_e" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_leu__L_c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_leu__L_e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11067"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11025"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction id="R_t_Lcystin_ser__L" name="t_Lcystin_ser__L" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub">
-        <listOfReactants>
-          <speciesReference species="M_Lcystin_e" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ser__L_c" stoichiometry="1" constant="true"/>
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-        <listOfProducts>
-          <speciesReference species="M_Lcystin_c" stoichiometry="1" constant="true"/>
-          <speciesReference species="M_ser__L_e" stoichiometry="1" constant="true"/>
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-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11025"/>
-            <fbc:geneProductRef fbc:geneProduct="G_HGNC__58__11067"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-    </listOfReactions>
-    <fbc:listOfObjectives fbc:activeObjective="obj">
-      <fbc:objective fbc:id="obj" fbc:type="maximize">
-        <fbc:listOfFluxObjectives>
-          <fbc:fluxObjective fbc:reaction="R_Biomass" fbc:coefficient="1"/>
-        </fbc:listOfFluxObjectives>
-      </fbc:objective>
-    </fbc:listOfObjectives>
-    <fbc:listOfGeneProducts>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11830" fbc:name="G_HGNC:11830" fbc:label="G_HGNC__58__11830">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TK1</p>
-            <p>ENSG: ENSG00000167900</p>
-            <p>HGNC ID: HGNC:11830</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11831" fbc:name="G_HGNC:11831" fbc:label="G_HGNC__58__11831">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TK2</p>
-            <p>ENSG: ENSG00000166548</p>
-            <p>HGNC ID: HGNC:11831</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4925" fbc:name="G_HGNC:4925" fbc:label="G_HGNC__58__4925">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HK3</p>
-            <p>ENSG: ENSG00000160883</p>
-            <p>HGNC ID: HGNC:4925</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4195" fbc:name="G_HGNC:4195" fbc:label="G_HGNC__58__4195">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GCK</p>
-            <p>ENSG: ENSG00000106633</p>
-            <p>HGNC ID: HGNC:4195</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4922" fbc:name="G_HGNC:4922" fbc:label="G_HGNC__58__4922">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HK1</p>
-            <p>ENSG: ENSG00000156515</p>
-            <p>HGNC ID: HGNC:4922</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4923" fbc:name="G_HGNC:4923" fbc:label="G_HGNC__58__4923">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HK2</p>
-            <p>ENSG: ENSG00000159399</p>
-            <p>HGNC ID: HGNC:4923</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23302" fbc:name="G_HGNC:23302" fbc:label="G_HGNC__58__23302">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HKDC1</p>
-            <p>ENSG: ENSG00000156510</p>
-            <p>HGNC ID: HGNC:23302</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4056" fbc:name="G_HGNC:4056" fbc:label="G_HGNC__58__4056">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: G6PC1</p>
-            <p>ENSG: ENSG00000131482</p>
-            <p>HGNC ID: HGNC:4056</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__28906" fbc:name="G_HGNC:28906" fbc:label="G_HGNC__58__28906">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: G6PC2</p>
-            <p>ENSG: ENSG00000152254</p>
-            <p>HGNC ID: HGNC:28906</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24861" fbc:name="G_HGNC:24861" fbc:label="G_HGNC__58__24861">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: G6PC3</p>
-            <p>ENSG: ENSG00000141349</p>
-            <p>HGNC ID: HGNC:24861</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4458" fbc:name="G_HGNC:4458" fbc:label="G_HGNC__58__4458">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPI</p>
-            <p>ENSG: ENSG00000105220</p>
-            <p>HGNC ID: HGNC:4458</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8877" fbc:name="G_HGNC:8877" fbc:label="G_HGNC__58__8877">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PFKM</p>
-            <p>ENSG: ENSG00000152556</p>
-            <p>HGNC ID: HGNC:8877</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8876" fbc:name="G_HGNC:8876" fbc:label="G_HGNC__58__8876">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PFKL</p>
-            <p>ENSG: ENSG00000141959</p>
-            <p>HGNC ID: HGNC:8876</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8878" fbc:name="G_HGNC:8878" fbc:label="G_HGNC__58__8878">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PFKP</p>
-            <p>ENSG: ENSG00000067057</p>
-            <p>HGNC ID: HGNC:8878</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3606" fbc:name="G_HGNC:3606" fbc:label="G_HGNC__58__3606">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FBP1</p>
-            <p>ENSG: ENSG00000165140</p>
-            <p>HGNC ID: HGNC:3606</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3607" fbc:name="G_HGNC:3607" fbc:label="G_HGNC__58__3607">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FBP2</p>
-            <p>ENSG: ENSG00000130957</p>
-            <p>HGNC ID: HGNC:3607</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__417" fbc:name="G_HGNC:417" fbc:label="G_HGNC__58__417">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDOB</p>
-            <p>ENSG: ENSG00000136872</p>
-            <p>HGNC ID: HGNC:417</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__418" fbc:name="G_HGNC:418" fbc:label="G_HGNC__58__418">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDOC</p>
-            <p>ENSG: ENSG00000109107</p>
-            <p>HGNC ID: HGNC:418</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__414" fbc:name="G_HGNC:414" fbc:label="G_HGNC__58__414">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDOA</p>
-            <p>ENSG: ENSG00000149925</p>
-            <p>HGNC ID: HGNC:414</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12009" fbc:name="G_HGNC:12009" fbc:label="G_HGNC__58__12009">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TPI1</p>
-            <p>ENSG: ENSG00000111669</p>
-            <p>HGNC ID: HGNC:12009</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24864" fbc:name="G_HGNC:24864" fbc:label="G_HGNC__58__24864">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GAPDHS</p>
-            <p>ENSG: ENSG00000105679</p>
-            <p>HGNC ID: HGNC:24864</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4141" fbc:name="G_HGNC:4141" fbc:label="G_HGNC__58__4141">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GAPDH</p>
-            <p>ENSG: ENSG00000111640</p>
-            <p>HGNC ID: HGNC:4141</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8896" fbc:name="G_HGNC:8896" fbc:label="G_HGNC__58__8896">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGK1</p>
-            <p>ENSG: ENSG00000102144</p>
-            <p>HGNC ID: HGNC:8896</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8898" fbc:name="G_HGNC:8898" fbc:label="G_HGNC__58__8898">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGK2</p>
-            <p>ENSG: ENSG00000170950</p>
-            <p>HGNC ID: HGNC:8898</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8889" fbc:name="G_HGNC:8889" fbc:label="G_HGNC__58__8889">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGAM2</p>
-            <p>ENSG: ENSG00000164708</p>
-            <p>HGNC ID: HGNC:8889</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1093" fbc:name="G_HGNC:1093" fbc:label="G_HGNC__58__1093">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: BPGM</p>
-            <p>ENSG: ENSG00000172331</p>
-            <p>HGNC ID: HGNC:1093</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8888" fbc:name="G_HGNC:8888" fbc:label="G_HGNC__58__8888">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGAM1</p>
-            <p>ENSG: ENSG00000171314</p>
-            <p>HGNC ID: HGNC:8888</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3353" fbc:name="G_HGNC:3353" fbc:label="G_HGNC__58__3353">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ENO2</p>
-            <p>ENSG: ENSG00000111674</p>
-            <p>HGNC ID: HGNC:3353</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3350" fbc:name="G_HGNC:3350" fbc:label="G_HGNC__58__3350">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ENO1</p>
-            <p>ENSG: ENSG00000074800</p>
-            <p>HGNC ID: HGNC:3350</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3354" fbc:name="G_HGNC:3354" fbc:label="G_HGNC__58__3354">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ENO3</p>
-            <p>ENSG: ENSG00000108515</p>
-            <p>HGNC ID: HGNC:3354</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9021" fbc:name="G_HGNC:9021" fbc:label="G_HGNC__58__9021">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PKM</p>
-            <p>ENSG: ENSG00000067225</p>
-            <p>HGNC ID: HGNC:9021</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9020" fbc:name="G_HGNC:9020" fbc:label="G_HGNC__58__9020">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PKLR</p>
-            <p>ENSG: ENSG00000143627</p>
-            <p>HGNC ID: HGNC:9020</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30866" fbc:name="G_HGNC:30866" fbc:label="G_HGNC__58__30866">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UEVLD</p>
-            <p>ENSG: ENSG00000151116</p>
-            <p>HGNC ID: HGNC:30866</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__28335" fbc:name="G_HGNC:28335" fbc:label="G_HGNC__58__28335">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LDHAL6A</p>
-            <p>ENSG: ENSG00000166800</p>
-            <p>HGNC ID: HGNC:28335</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21481" fbc:name="G_HGNC:21481" fbc:label="G_HGNC__58__21481">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LDHAL6B</p>
-            <p>ENSG: ENSG00000171989</p>
-            <p>HGNC ID: HGNC:21481</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6535" fbc:name="G_HGNC:6535" fbc:label="G_HGNC__58__6535">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LDHA</p>
-            <p>ENSG: ENSG00000134333</p>
-            <p>HGNC ID: HGNC:6535</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6544" fbc:name="G_HGNC:6544" fbc:label="G_HGNC__58__6544">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LDHC</p>
-            <p>ENSG: ENSG00000166796</p>
-            <p>HGNC ID: HGNC:6544</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6541" fbc:name="G_HGNC:6541" fbc:label="G_HGNC__58__6541">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LDHB</p>
-            <p>ENSG: ENSG00000111716</p>
-            <p>HGNC ID: HGNC:6541</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9465" fbc:name="G_HGNC:9465" fbc:label="G_HGNC__58__9465">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRPS2</p>
-            <p>ENSG: ENSG00000101911</p>
-            <p>HGNC ID: HGNC:9465</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9463" fbc:name="G_HGNC:9463" fbc:label="G_HGNC__58__9463">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRPS1L1</p>
-            <p>ENSG: ENSG00000229937</p>
-            <p>HGNC ID: HGNC:9463</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9462" fbc:name="G_HGNC:9462" fbc:label="G_HGNC__58__9462">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRPS1</p>
-            <p>ENSG: ENSG00000147224</p>
-            <p>HGNC ID: HGNC:9462</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4057" fbc:name="G_HGNC:4057" fbc:label="G_HGNC__58__4057">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: G6PD</p>
-            <p>ENSG: ENSG00000160211</p>
-            <p>HGNC ID: HGNC:4057</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4795" fbc:name="G_HGNC:4795" fbc:label="G_HGNC__58__4795">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: H6PD</p>
-            <p>ENSG: ENSG00000049239</p>
-            <p>HGNC ID: HGNC:4795</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8903" fbc:name="G_HGNC:8903" fbc:label="G_HGNC__58__8903">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGLS</p>
-            <p>ENSG: ENSG00000130313</p>
-            <p>HGNC ID: HGNC:8903</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8891" fbc:name="G_HGNC:8891" fbc:label="G_HGNC__58__8891">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGD</p>
-            <p>ENSG: ENSG00000142657</p>
-            <p>HGNC ID: HGNC:8891</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10297" fbc:name="G_HGNC:10297" fbc:label="G_HGNC__58__10297">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RPIA</p>
-            <p>ENSG: ENSG00000153574</p>
-            <p>HGNC ID: HGNC:10297</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__25313" fbc:name="G_HGNC:25313" fbc:label="G_HGNC__58__25313">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TKTL2</p>
-            <p>ENSG: ENSG00000151005</p>
-            <p>HGNC ID: HGNC:25313</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11834" fbc:name="G_HGNC:11834" fbc:label="G_HGNC__58__11834">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TKT</p>
-            <p>ENSG: ENSG00000163931</p>
-            <p>HGNC ID: HGNC:11834</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11835" fbc:name="G_HGNC:11835" fbc:label="G_HGNC__58__11835">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TKTL1</p>
-            <p>ENSG: ENSG00000007350</p>
-            <p>HGNC ID: HGNC:11835</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10293" fbc:name="G_HGNC:10293" fbc:label="G_HGNC__58__10293">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RPE</p>
-            <p>ENSG: ENSG00000197713</p>
-            <p>HGNC ID: HGNC:10293</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__45241" fbc:name="G_HGNC:45241" fbc:label="G_HGNC__58__45241">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RPEL1</p>
-            <p>ENSG: ENSG00000235376</p>
-            <p>HGNC ID: HGNC:45241</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11559" fbc:name="G_HGNC:11559" fbc:label="G_HGNC__58__11559">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TALDO1</p>
-            <p>ENSG: ENSG00000177156</p>
-            <p>HGNC ID: HGNC:11559</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2898" fbc:name="G_HGNC:2898" fbc:label="G_HGNC__58__2898">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DLD</p>
-            <p>ENSG: ENSG00000091140</p>
-            <p>HGNC ID: HGNC:2898</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8807" fbc:name="G_HGNC:8807" fbc:label="G_HGNC__58__8807">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PDHA2</p>
-            <p>ENSG: ENSG00000163114</p>
-            <p>HGNC ID: HGNC:8807</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8808" fbc:name="G_HGNC:8808" fbc:label="G_HGNC__58__8808">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PDHB</p>
-            <p>ENSG: ENSG00000168291</p>
-            <p>HGNC ID: HGNC:8808</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8806" fbc:name="G_HGNC:8806" fbc:label="G_HGNC__58__8806">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PDHA1</p>
-            <p>ENSG: ENSG00000131828</p>
-            <p>HGNC ID: HGNC:8806</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2896" fbc:name="G_HGNC:2896" fbc:label="G_HGNC__58__2896">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DLAT</p>
-            <p>ENSG: ENSG00000150768</p>
-            <p>HGNC ID: HGNC:2896</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21350" fbc:name="G_HGNC:21350" fbc:label="G_HGNC__58__21350">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PDHX</p>
-            <p>ENSG: ENSG00000110435</p>
-            <p>HGNC ID: HGNC:21350</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8636" fbc:name="G_HGNC:8636" fbc:label="G_HGNC__58__8636">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PC</p>
-            <p>ENSG: ENSG00000173599</p>
-            <p>HGNC ID: HGNC:8636</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8724" fbc:name="G_HGNC:8724" fbc:label="G_HGNC__58__8724">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PCK1</p>
-            <p>ENSG: ENSG00000124253</p>
-            <p>HGNC ID: HGNC:8724</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2422" fbc:name="G_HGNC:2422" fbc:label="G_HGNC__58__2422">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CS</p>
-            <p>ENSG: ENSG00000062485</p>
-            <p>HGNC ID: HGNC:2422</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__117" fbc:name="G_HGNC:117" fbc:label="G_HGNC__58__117">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACO1</p>
-            <p>ENSG: ENSG00000122729</p>
-            <p>HGNC ID: HGNC:117</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__118" fbc:name="G_HGNC:118" fbc:label="G_HGNC__58__118">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACO2</p>
-            <p>ENSG: ENSG00000100412</p>
-            <p>HGNC ID: HGNC:118</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5385" fbc:name="G_HGNC:5385" fbc:label="G_HGNC__58__5385">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDH3B</p>
-            <p>ENSG: ENSG00000101365</p>
-            <p>HGNC ID: HGNC:5385</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5384" fbc:name="G_HGNC:5384" fbc:label="G_HGNC__58__5384">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDH3A</p>
-            <p>ENSG: ENSG00000166411</p>
-            <p>HGNC ID: HGNC:5384</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5386" fbc:name="G_HGNC:5386" fbc:label="G_HGNC__58__5386">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDH3G</p>
-            <p>ENSG: ENSG00000067829</p>
-            <p>HGNC ID: HGNC:5386</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5383" fbc:name="G_HGNC:5383" fbc:label="G_HGNC__58__5383">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDH2</p>
-            <p>ENSG: ENSG00000182054</p>
-            <p>HGNC ID: HGNC:5383</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2911" fbc:name="G_HGNC:2911" fbc:label="G_HGNC__58__2911">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DLST</p>
-            <p>ENSG: ENSG00000119689</p>
-            <p>HGNC ID: HGNC:2911</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8124" fbc:name="G_HGNC:8124" fbc:label="G_HGNC__58__8124">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: OGDH</p>
-            <p>ENSG: ENSG00000105953</p>
-            <p>HGNC ID: HGNC:8124</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11449" fbc:name="G_HGNC:11449" fbc:label="G_HGNC__58__11449">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SUCLG1</p>
-            <p>ENSG: ENSG00000163541</p>
-            <p>HGNC ID: HGNC:11449</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11450" fbc:name="G_HGNC:11450" fbc:label="G_HGNC__58__11450">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SUCLG2</p>
-            <p>ENSG: ENSG00000172340</p>
-            <p>HGNC ID: HGNC:11450</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10680" fbc:name="G_HGNC:10680" fbc:label="G_HGNC__58__10680">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDHA</p>
-            <p>ENSG: ENSG00000073578</p>
-            <p>HGNC ID: HGNC:10680</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10683" fbc:name="G_HGNC:10683" fbc:label="G_HGNC__58__10683">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDHD</p>
-            <p>ENSG: ENSG00000204370</p>
-            <p>HGNC ID: HGNC:10683</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10681" fbc:name="G_HGNC:10681" fbc:label="G_HGNC__58__10681">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDHB</p>
-            <p>ENSG: ENSG00000117118</p>
-            <p>HGNC ID: HGNC:10681</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10682" fbc:name="G_HGNC:10682" fbc:label="G_HGNC__58__10682">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDHC</p>
-            <p>ENSG: ENSG00000143252</p>
-            <p>HGNC ID: HGNC:10682</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3700" fbc:name="G_HGNC:3700" fbc:label="G_HGNC__58__3700">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FH</p>
-            <p>ENSG: ENSG00000091483</p>
-            <p>HGNC ID: HGNC:3700</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6971" fbc:name="G_HGNC:6971" fbc:label="G_HGNC__58__6971">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MDH2</p>
-            <p>ENSG: ENSG00000146701</p>
-            <p>HGNC ID: HGNC:6971</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6984" fbc:name="G_HGNC:6984" fbc:label="G_HGNC__58__6984">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ME2</p>
-            <p>ENSG: ENSG00000082212</p>
-            <p>HGNC ID: HGNC:6984</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6985" fbc:name="G_HGNC:6985" fbc:label="G_HGNC__58__6985">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ME3</p>
-            <p>ENSG: ENSG00000151376</p>
-            <p>HGNC ID: HGNC:6985</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6983" fbc:name="G_HGNC:6983" fbc:label="G_HGNC__58__6983">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ME1</p>
-            <p>ENSG: ENSG00000065833</p>
-            <p>HGNC ID: HGNC:6983</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__115" fbc:name="G_HGNC:115" fbc:label="G_HGNC__58__115">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACLY</p>
-            <p>ENSG: ENSG00000131473</p>
-            <p>HGNC ID: HGNC:115</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6970" fbc:name="G_HGNC:6970" fbc:label="G_HGNC__58__6970">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MDH1</p>
-            <p>ENSG: ENSG00000014641</p>
-            <p>HGNC ID: HGNC:6970</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17836" fbc:name="G_HGNC:17836" fbc:label="G_HGNC__58__17836">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MDH1B</p>
-            <p>ENSG: ENSG00000138400</p>
-            <p>HGNC ID: HGNC:17836</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10980" fbc:name="G_HGNC:10980" fbc:label="G_HGNC__58__10980">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A10</p>
-            <p>ENSG: ENSG00000183048</p>
-            <p>HGNC ID: HGNC:10980</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10981" fbc:name="G_HGNC:10981" fbc:label="G_HGNC__58__10981">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A11</p>
-            <p>ENSG: ENSG00000108528</p>
-            <p>HGNC ID: HGNC:10981</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5382" fbc:name="G_HGNC:5382" fbc:label="G_HGNC__58__5382">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDH1</p>
-            <p>ENSG: ENSG00000138413</p>
-            <p>HGNC ID: HGNC:5382</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9226" fbc:name="G_HGNC:9226" fbc:label="G_HGNC__58__9226">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PPA1</p>
-            <p>ENSG: ENSG00000180817</p>
-            <p>HGNC ID: HGNC:9226</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30042" fbc:name="G_HGNC:30042" fbc:label="G_HGNC__58__30042">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LHPP</p>
-            <p>ENSG: ENSG00000107902</p>
-            <p>HGNC ID: HGNC:30042</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7703" fbc:name="G_HGNC:7703" fbc:label="G_HGNC__58__7703">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB8</p>
-            <p>ENSG: ENSG00000166136</p>
-            <p>HGNC ID: HGNC:7703</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7690" fbc:name="G_HGNC:7690" fbc:label="G_HGNC__58__7690">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA6</p>
-            <p>ENSG: ENSG00000184983</p>
-            <p>HGNC ID: HGNC:7690</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7716" fbc:name="G_HGNC:7716" fbc:label="G_HGNC__58__7716">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFV1</p>
-            <p>ENSG: ENSG00000167792</p>
-            <p>HGNC ID: HGNC:7716</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7717" fbc:name="G_HGNC:7717" fbc:label="G_HGNC__58__7717">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFV2</p>
-            <p>ENSG: ENSG00000178127</p>
-            <p>HGNC ID: HGNC:7717</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7461" fbc:name="G_HGNC:7461" fbc:label="G_HGNC__58__7461">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND5</p>
-            <p>ENSG: ENSG00000198786</p>
-            <p>HGNC ID: HGNC:7461</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7696" fbc:name="G_HGNC:7696" fbc:label="G_HGNC__58__7696">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB10</p>
-            <p>ENSG: ENSG00000140990</p>
-            <p>HGNC ID: HGNC:7696</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20371" fbc:name="G_HGNC:20371" fbc:label="G_HGNC__58__20371">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA11</p>
-            <p>ENSG: ENSG00000174886</p>
-            <p>HGNC ID: HGNC:20371</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7460" fbc:name="G_HGNC:7460" fbc:label="G_HGNC__58__7460">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND4L</p>
-            <p>ENSG: ENSG00000212907</p>
-            <p>HGNC ID: HGNC:7460</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7685" fbc:name="G_HGNC:7685" fbc:label="G_HGNC__58__7685">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA2</p>
-            <p>ENSG: ENSG00000131495</p>
-            <p>HGNC ID: HGNC:7685</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7714" fbc:name="G_HGNC:7714" fbc:label="G_HGNC__58__7714">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS7</p>
-            <p>ENSG: ENSG00000115286</p>
-            <p>HGNC ID: HGNC:7714</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7686" fbc:name="G_HGNC:7686" fbc:label="G_HGNC__58__7686">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA3</p>
-            <p>ENSG: ENSG00000170906</p>
-            <p>HGNC ID: HGNC:7686</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7705" fbc:name="G_HGNC:7705" fbc:label="G_HGNC__58__7705">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFC1</p>
-            <p>ENSG: ENSG00000109390</p>
-            <p>HGNC ID: HGNC:7705</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7455" fbc:name="G_HGNC:7455" fbc:label="G_HGNC__58__7455">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND1</p>
-            <p>ENSG: ENSG00000198888</p>
-            <p>HGNC ID: HGNC:7455</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7710" fbc:name="G_HGNC:7710" fbc:label="G_HGNC__58__7710">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS3</p>
-            <p>ENSG: ENSG00000213619</p>
-            <p>HGNC ID: HGNC:7710</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17194" fbc:name="G_HGNC:17194" fbc:label="G_HGNC__58__17194">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA13</p>
-            <p>ENSG: ENSG00000186010</p>
-            <p>HGNC ID: HGNC:17194</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7699" fbc:name="G_HGNC:7699" fbc:label="G_HGNC__58__7699">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB4</p>
-            <p>ENSG: ENSG00000065518</p>
-            <p>HGNC ID: HGNC:7699</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7692" fbc:name="G_HGNC:7692" fbc:label="G_HGNC__58__7692">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA8</p>
-            <p>ENSG: ENSG00000119421</p>
-            <p>HGNC ID: HGNC:7692</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7684" fbc:name="G_HGNC:7684" fbc:label="G_HGNC__58__7684">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA10</p>
-            <p>ENSG: ENSG00000130414</p>
-            <p>HGNC ID: HGNC:7684</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7707" fbc:name="G_HGNC:7707" fbc:label="G_HGNC__58__7707">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS1</p>
-            <p>ENSG: ENSG00000023228</p>
-            <p>HGNC ID: HGNC:7707</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7701" fbc:name="G_HGNC:7701" fbc:label="G_HGNC__58__7701">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB6</p>
-            <p>ENSG: ENSG00000165264</p>
-            <p>HGNC ID: HGNC:7701</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7702" fbc:name="G_HGNC:7702" fbc:label="G_HGNC__58__7702">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB7</p>
-            <p>ENSG: ENSG00000099795</p>
-            <p>HGNC ID: HGNC:7702</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7708" fbc:name="G_HGNC:7708" fbc:label="G_HGNC__58__7708">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS2</p>
-            <p>ENSG: ENSG00000158864</p>
-            <p>HGNC ID: HGNC:7708</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7458" fbc:name="G_HGNC:7458" fbc:label="G_HGNC__58__7458">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND3</p>
-            <p>ENSG: ENSG00000198840</p>
-            <p>HGNC ID: HGNC:7458</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7697" fbc:name="G_HGNC:7697" fbc:label="G_HGNC__58__7697">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB2</p>
-            <p>ENSG: ENSG00000090266</p>
-            <p>HGNC ID: HGNC:7697</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7456" fbc:name="G_HGNC:7456" fbc:label="G_HGNC__58__7456">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND2</p>
-            <p>ENSG: ENSG00000198763</p>
-            <p>HGNC ID: HGNC:7456</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7683" fbc:name="G_HGNC:7683" fbc:label="G_HGNC__58__7683">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA1</p>
-            <p>ENSG: ENSG00000125356</p>
-            <p>HGNC ID: HGNC:7683</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7712" fbc:name="G_HGNC:7712" fbc:label="G_HGNC__58__7712">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS5</p>
-            <p>ENSG: ENSG00000168653</p>
-            <p>HGNC ID: HGNC:7712</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7700" fbc:name="G_HGNC:7700" fbc:label="G_HGNC__58__7700">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB5</p>
-            <p>ENSG: ENSG00000136521</p>
-            <p>HGNC ID: HGNC:7700</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7462" fbc:name="G_HGNC:7462" fbc:label="G_HGNC__58__7462">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND6</p>
-            <p>ENSG: ENSG00000198695</p>
-            <p>HGNC ID: HGNC:7462</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7459" fbc:name="G_HGNC:7459" fbc:label="G_HGNC__58__7459">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ND4</p>
-            <p>ENSG: ENSG00000198886</p>
-            <p>HGNC ID: HGNC:7459</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7688" fbc:name="G_HGNC:7688" fbc:label="G_HGNC__58__7688">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA5</p>
-            <p>ENSG: ENSG00000128609</p>
-            <p>HGNC ID: HGNC:7688</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7694" fbc:name="G_HGNC:7694" fbc:label="G_HGNC__58__7694">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFAB1</p>
-            <p>ENSG: ENSG00000004779</p>
-            <p>HGNC ID: HGNC:7694</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7715" fbc:name="G_HGNC:7715" fbc:label="G_HGNC__58__7715">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFS8</p>
-            <p>ENSG: ENSG00000110717</p>
-            <p>HGNC ID: HGNC:7715</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7693" fbc:name="G_HGNC:7693" fbc:label="G_HGNC__58__7693">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFA9</p>
-            <p>ENSG: ENSG00000139180</p>
-            <p>HGNC ID: HGNC:7693</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20372" fbc:name="G_HGNC:20372" fbc:label="G_HGNC__58__20372">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB11</p>
-            <p>ENSG: ENSG00000147123</p>
-            <p>HGNC ID: HGNC:20372</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7706" fbc:name="G_HGNC:7706" fbc:label="G_HGNC__58__7706">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFC2</p>
-            <p>ENSG: ENSG00000151366</p>
-            <p>HGNC ID: HGNC:7706</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7698" fbc:name="G_HGNC:7698" fbc:label="G_HGNC__58__7698">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB3</p>
-            <p>ENSG: ENSG00000119013</p>
-            <p>HGNC ID: HGNC:7698</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7704" fbc:name="G_HGNC:7704" fbc:label="G_HGNC__58__7704">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB9</p>
-            <p>ENSG: ENSG00000147684</p>
-            <p>HGNC ID: HGNC:7704</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7695" fbc:name="G_HGNC:7695" fbc:label="G_HGNC__58__7695">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NDUFB1</p>
-            <p>ENSG: ENSG00000183648</p>
-            <p>HGNC ID: HGNC:7695</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3481" fbc:name="G_HGNC:3481" fbc:label="G_HGNC__58__3481">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ETFA</p>
-            <p>ENSG: ENSG00000140374</p>
-            <p>HGNC ID: HGNC:3481</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3482" fbc:name="G_HGNC:3482" fbc:label="G_HGNC__58__3482">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ETFB</p>
-            <p>ENSG: ENSG00000105379</p>
-            <p>HGNC ID: HGNC:3482</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3483" fbc:name="G_HGNC:3483" fbc:label="G_HGNC__58__3483">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ETFDH</p>
-            <p>ENSG: ENSG00000171503</p>
-            <p>HGNC ID: HGNC:3483</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2579" fbc:name="G_HGNC:2579" fbc:label="G_HGNC__58__2579">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CYC1</p>
-            <p>ENSG: ENSG00000179091</p>
-            <p>HGNC ID: HGNC:2579</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12590" fbc:name="G_HGNC:12590" fbc:label="G_HGNC__58__12590">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRH</p>
-            <p>ENSG: ENSG00000173660</p>
-            <p>HGNC ID: HGNC:12590</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__29594" fbc:name="G_HGNC:29594" fbc:label="G_HGNC__58__29594">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRQ</p>
-            <p>ENSG: ENSG00000164405</p>
-            <p>HGNC ID: HGNC:29594</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12587" fbc:name="G_HGNC:12587" fbc:label="G_HGNC__58__12587">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRFS1</p>
-            <p>ENSG: ENSG00000169021</p>
-            <p>HGNC ID: HGNC:12587</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12582" fbc:name="G_HGNC:12582" fbc:label="G_HGNC__58__12582">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRB</p>
-            <p>ENSG: ENSG00000156467</p>
-            <p>HGNC ID: HGNC:12582</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30863" fbc:name="G_HGNC:30863" fbc:label="G_HGNC__58__30863">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCR10</p>
-            <p>ENSG: ENSG00000184076</p>
-            <p>HGNC ID: HGNC:30863</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7427" fbc:name="G_HGNC:7427" fbc:label="G_HGNC__58__7427">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-CYB</p>
-            <p>ENSG: ENSG00000198727</p>
-            <p>HGNC ID: HGNC:7427</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30862" fbc:name="G_HGNC:30862" fbc:label="G_HGNC__58__30862">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCR11</p>
-            <p>ENSG: ENSG00000127540</p>
-            <p>HGNC ID: HGNC:30862</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12586" fbc:name="G_HGNC:12586" fbc:label="G_HGNC__58__12586">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRC2</p>
-            <p>ENSG: ENSG00000140740</p>
-            <p>HGNC ID: HGNC:12586</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12585" fbc:name="G_HGNC:12585" fbc:label="G_HGNC__58__12585">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UQCRC1</p>
-            <p>ENSG: ENSG00000010256</p>
-            <p>HGNC ID: HGNC:12585</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2285" fbc:name="G_HGNC:2285" fbc:label="G_HGNC__58__2285">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX6C</p>
-            <p>ENSG: ENSG00000164919</p>
-            <p>HGNC ID: HGNC:2285</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2291" fbc:name="G_HGNC:2291" fbc:label="G_HGNC__58__2291">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX7B</p>
-            <p>ENSG: ENSG00000131174</p>
-            <p>HGNC ID: HGNC:2291</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24381" fbc:name="G_HGNC:24381" fbc:label="G_HGNC__58__24381">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX7B2</p>
-            <p>ENSG: ENSG00000170516</p>
-            <p>HGNC ID: HGNC:24381</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2267" fbc:name="G_HGNC:2267" fbc:label="G_HGNC__58__2267">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX5A</p>
-            <p>ENSG: ENSG00000178741</p>
-            <p>HGNC ID: HGNC:2267</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2287" fbc:name="G_HGNC:2287" fbc:label="G_HGNC__58__2287">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX7A1</p>
-            <p>ENSG: ENSG00000161281</p>
-            <p>HGNC ID: HGNC:2287</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7419" fbc:name="G_HGNC:7419" fbc:label="G_HGNC__58__7419">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-CO1</p>
-            <p>ENSG: ENSG00000198804</p>
-            <p>HGNC ID: HGNC:7419</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24380" fbc:name="G_HGNC:24380" fbc:label="G_HGNC__58__24380">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX6B2</p>
-            <p>ENSG: ENSG00000160471</p>
-            <p>HGNC ID: HGNC:24380</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7421" fbc:name="G_HGNC:7421" fbc:label="G_HGNC__58__7421">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-CO2</p>
-            <p>ENSG: ENSG00000198712</p>
-            <p>HGNC ID: HGNC:7421</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2288" fbc:name="G_HGNC:2288" fbc:label="G_HGNC__58__2288">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX7A2</p>
-            <p>ENSG: ENSG00000112695</p>
-            <p>HGNC ID: HGNC:2288</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16232" fbc:name="G_HGNC:16232" fbc:label="G_HGNC__58__16232">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX4I2</p>
-            <p>ENSG: ENSG00000131055</p>
-            <p>HGNC ID: HGNC:16232</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2294" fbc:name="G_HGNC:2294" fbc:label="G_HGNC__58__2294">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX8A</p>
-            <p>ENSG: ENSG00000176340</p>
-            <p>HGNC ID: HGNC:2294</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2277" fbc:name="G_HGNC:2277" fbc:label="G_HGNC__58__2277">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX6A1</p>
-            <p>ENSG: ENSG00000111775</p>
-            <p>HGNC ID: HGNC:2277</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2280" fbc:name="G_HGNC:2280" fbc:label="G_HGNC__58__2280">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX6B1</p>
-            <p>ENSG: ENSG00000126267</p>
-            <p>HGNC ID: HGNC:2280</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24382" fbc:name="G_HGNC:24382" fbc:label="G_HGNC__58__24382">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX8C</p>
-            <p>ENSG: ENSG00000187581</p>
-            <p>HGNC ID: HGNC:24382</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2292" fbc:name="G_HGNC:2292" fbc:label="G_HGNC__58__2292">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX7C</p>
-            <p>ENSG: ENSG00000127184</p>
-            <p>HGNC ID: HGNC:2292</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7422" fbc:name="G_HGNC:7422" fbc:label="G_HGNC__58__7422">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-CO3</p>
-            <p>ENSG: ENSG00000198938</p>
-            <p>HGNC ID: HGNC:7422</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2269" fbc:name="G_HGNC:2269" fbc:label="G_HGNC__58__2269">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX5B</p>
-            <p>ENSG: ENSG00000135940</p>
-            <p>HGNC ID: HGNC:2269</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2265" fbc:name="G_HGNC:2265" fbc:label="G_HGNC__58__2265">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX4I1</p>
-            <p>ENSG: ENSG00000131143</p>
-            <p>HGNC ID: HGNC:2265</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2279" fbc:name="G_HGNC:2279" fbc:label="G_HGNC__58__2279">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: COX6A2</p>
-            <p>ENSG: ENSG00000156885</p>
-            <p>HGNC ID: HGNC:2279</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7415" fbc:name="G_HGNC:7415" fbc:label="G_HGNC__58__7415">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ATP8</p>
-            <p>ENSG: ENSG00000228253</p>
-            <p>HGNC ID: HGNC:7415</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__845" fbc:name="G_HGNC:845" fbc:label="G_HGNC__58__845">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5PD</p>
-            <p>ENSG: ENSG00000167863</p>
-            <p>HGNC ID: HGNC:845</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__833" fbc:name="G_HGNC:833" fbc:label="G_HGNC__58__833">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5F1C</p>
-            <p>ENSG: ENSG00000165629</p>
-            <p>HGNC ID: HGNC:833</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__843" fbc:name="G_HGNC:843" fbc:label="G_HGNC__58__843">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5MC3</p>
-            <p>ENSG: ENSG00000154518</p>
-            <p>HGNC ID: HGNC:843</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__838" fbc:name="G_HGNC:838" fbc:label="G_HGNC__58__838">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5F1E</p>
-            <p>ENSG: ENSG00000124172</p>
-            <p>HGNC ID: HGNC:838</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__847" fbc:name="G_HGNC:847" fbc:label="G_HGNC__58__847">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5PF</p>
-            <p>ENSG: ENSG00000154723</p>
-            <p>HGNC ID: HGNC:847</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__848" fbc:name="G_HGNC:848" fbc:label="G_HGNC__58__848">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5MF</p>
-            <p>ENSG: ENSG00000241468</p>
-            <p>HGNC ID: HGNC:848</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__850" fbc:name="G_HGNC:850" fbc:label="G_HGNC__58__850">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5PO</p>
-            <p>ENSG: ENSG00000241837</p>
-            <p>HGNC ID: HGNC:850</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__840" fbc:name="G_HGNC:840" fbc:label="G_HGNC__58__840">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5PB</p>
-            <p>ENSG: ENSG00000116459</p>
-            <p>HGNC ID: HGNC:840</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__841" fbc:name="G_HGNC:841" fbc:label="G_HGNC__58__841">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5MC1</p>
-            <p>ENSG: ENSG00000159199</p>
-            <p>HGNC ID: HGNC:841</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__830" fbc:name="G_HGNC:830" fbc:label="G_HGNC__58__830">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5F1B</p>
-            <p>ENSG: ENSG00000110955</p>
-            <p>HGNC ID: HGNC:830</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__846" fbc:name="G_HGNC:846" fbc:label="G_HGNC__58__846">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5ME</p>
-            <p>ENSG: ENSG00000169020</p>
-            <p>HGNC ID: HGNC:846</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__823" fbc:name="G_HGNC:823" fbc:label="G_HGNC__58__823">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5F1A</p>
-            <p>ENSG: ENSG00000152234</p>
-            <p>HGNC ID: HGNC:823</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__842" fbc:name="G_HGNC:842" fbc:label="G_HGNC__58__842">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5MC2</p>
-            <p>ENSG: ENSG00000135390</p>
-            <p>HGNC ID: HGNC:842</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7414" fbc:name="G_HGNC:7414" fbc:label="G_HGNC__58__7414">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MT-ATP6</p>
-            <p>ENSG: ENSG00000198899</p>
-            <p>HGNC ID: HGNC:7414</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14247" fbc:name="G_HGNC:14247" fbc:label="G_HGNC__58__14247">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5MG</p>
-            <p>ENSG: ENSG00000167283</p>
-            <p>HGNC ID: HGNC:14247</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__837" fbc:name="G_HGNC:837" fbc:label="G_HGNC__58__837">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATP5F1D</p>
-            <p>ENSG: ENSG00000099624</p>
-            <p>HGNC ID: HGNC:837</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4312" fbc:name="G_HGNC:4312" fbc:label="G_HGNC__58__4312">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GCLM</p>
-            <p>ENSG: ENSG00000023909</p>
-            <p>HGNC ID: HGNC:4312</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4311" fbc:name="G_HGNC:4311" fbc:label="G_HGNC__58__4311">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GCLC</p>
-            <p>ENSG: ENSG00000001084</p>
-            <p>HGNC ID: HGNC:4311</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4624" fbc:name="G_HGNC:4624" fbc:label="G_HGNC__58__4624">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GSS</p>
-            <p>ENSG: ENSG00000100983</p>
-            <p>HGNC ID: HGNC:4624</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11180" fbc:name="G_HGNC:11180" fbc:label="G_HGNC__58__11180">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SOD2</p>
-            <p>ENSG: ENSG00000291237</p>
-            <p>HGNC ID: HGNC:11180</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9352" fbc:name="G_HGNC:9352" fbc:label="G_HGNC__58__9352">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRDX1</p>
-            <p>ENSG: ENSG00000117450</p>
-            <p>HGNC ID: HGNC:9352</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4553" fbc:name="G_HGNC:4553" fbc:label="G_HGNC__58__4553">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPX1</p>
-            <p>ENSG: ENSG00000233276</p>
-            <p>HGNC ID: HGNC:4553</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4556" fbc:name="G_HGNC:4556" fbc:label="G_HGNC__58__4556">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPX4</p>
-            <p>ENSG: ENSG00000167468</p>
-            <p>HGNC ID: HGNC:4556</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9353" fbc:name="G_HGNC:9353" fbc:label="G_HGNC__58__9353">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRDX2</p>
-            <p>ENSG: ENSG00000167815</p>
-            <p>HGNC ID: HGNC:9353</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4554" fbc:name="G_HGNC:4554" fbc:label="G_HGNC__58__4554">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPX2</p>
-            <p>ENSG: ENSG00000176153</p>
-            <p>HGNC ID: HGNC:4554</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9354" fbc:name="G_HGNC:9354" fbc:label="G_HGNC__58__9354">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRDX3</p>
-            <p>ENSG: ENSG00000165672</p>
-            <p>HGNC ID: HGNC:9354</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4623" fbc:name="G_HGNC:4623" fbc:label="G_HGNC__58__4623">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GSR</p>
-            <p>ENSG: ENSG00000104687</p>
-            <p>HGNC ID: HGNC:4623</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21606" fbc:name="G_HGNC:21606" fbc:label="G_HGNC__58__21606">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MPC1</p>
-            <p>ENSG: ENSG00000060762</p>
-            <p>HGNC ID: HGNC:21606</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__24515" fbc:name="G_HGNC:24515" fbc:label="G_HGNC__58__24515">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MPC2</p>
-            <p>ENSG: ENSG00000143158</p>
-            <p>HGNC ID: HGNC:24515</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10922" fbc:name="G_HGNC:10922" fbc:label="G_HGNC__58__10922">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC16A1</p>
-            <p>ENSG: ENSG00000155380</p>
-            <p>HGNC ID: HGNC:10922</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10979" fbc:name="G_HGNC:10979" fbc:label="G_HGNC__58__10979">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A1</p>
-            <p>ENSG: ENSG00000100075</p>
-            <p>HGNC ID: HGNC:10979</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10989" fbc:name="G_HGNC:10989" fbc:label="G_HGNC__58__10989">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A3</p>
-            <p>ENSG: ENSG00000075415</p>
-            <p>HGNC ID: HGNC:10989</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10992" fbc:name="G_HGNC:10992" fbc:label="G_HGNC__58__10992">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A6</p>
-            <p>ENSG: ENSG00000169100</p>
-            <p>HGNC ID: HGNC:10992</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10991" fbc:name="G_HGNC:10991" fbc:label="G_HGNC__58__10991">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A5</p>
-            <p>ENSG: ENSG00000005022</p>
-            <p>HGNC ID: HGNC:10991</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10990" fbc:name="G_HGNC:10990" fbc:label="G_HGNC__58__10990">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A4</p>
-            <p>ENSG: ENSG00000151729</p>
-            <p>HGNC ID: HGNC:10990</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7863" fbc:name="G_HGNC:7863" fbc:label="G_HGNC__58__7863">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NNT</p>
-            <p>ENSG: ENSG00000112992</p>
-            <p>HGNC ID: HGNC:7863</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__642" fbc:name="G_HGNC:642" fbc:label="G_HGNC__58__642">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AQP8</p>
-            <p>ENSG: ENSG00000103375</p>
-            <p>HGNC ID: HGNC:642</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1371" fbc:name="G_HGNC:1371" fbc:label="G_HGNC__58__1371">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA12</p>
-            <p>ENSG: ENSG00000074410</p>
-            <p>HGNC ID: HGNC:1371</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1372" fbc:name="G_HGNC:1372" fbc:label="G_HGNC__58__1372">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA14</p>
-            <p>ENSG: ENSG00000118298</p>
-            <p>HGNC ID: HGNC:1372</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1368" fbc:name="G_HGNC:1368" fbc:label="G_HGNC__58__1368">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA1</p>
-            <p>ENSG: ENSG00000133742</p>
-            <p>HGNC ID: HGNC:1368</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1375" fbc:name="G_HGNC:1375" fbc:label="G_HGNC__58__1375">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA4</p>
-            <p>ENSG: ENSG00000167434</p>
-            <p>HGNC ID: HGNC:1375</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1380" fbc:name="G_HGNC:1380" fbc:label="G_HGNC__58__1380">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA6</p>
-            <p>ENSG: ENSG00000131686</p>
-            <p>HGNC ID: HGNC:1380</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1381" fbc:name="G_HGNC:1381" fbc:label="G_HGNC__58__1381">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA7</p>
-            <p>ENSG: ENSG00000168748</p>
-            <p>HGNC ID: HGNC:1381</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1374" fbc:name="G_HGNC:1374" fbc:label="G_HGNC__58__1374">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA3</p>
-            <p>ENSG: ENSG00000164879</p>
-            <p>HGNC ID: HGNC:1374</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14914" fbc:name="G_HGNC:14914" fbc:label="G_HGNC__58__14914">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA13</p>
-            <p>ENSG: ENSG00000185015</p>
-            <p>HGNC ID: HGNC:14914</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1383" fbc:name="G_HGNC:1383" fbc:label="G_HGNC__58__1383">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA9</p>
-            <p>ENSG: ENSG00000107159</p>
-            <p>HGNC ID: HGNC:1383</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1373" fbc:name="G_HGNC:1373" fbc:label="G_HGNC__58__1373">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA2</p>
-            <p>ENSG: ENSG00000104267</p>
-            <p>HGNC ID: HGNC:1373</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1377" fbc:name="G_HGNC:1377" fbc:label="G_HGNC__58__1377">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA5A</p>
-            <p>ENSG: ENSG00000174990</p>
-            <p>HGNC ID: HGNC:1377</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1378" fbc:name="G_HGNC:1378" fbc:label="G_HGNC__58__1378">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CA5B</p>
-            <p>ENSG: ENSG00000169239</p>
-            <p>HGNC ID: HGNC:1378</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4331" fbc:name="G_HGNC:4331" fbc:label="G_HGNC__58__4331">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GLS</p>
-            <p>ENSG: ENSG00000115419</p>
-            <p>HGNC ID: HGNC:4331</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4341" fbc:name="G_HGNC:4341" fbc:label="G_HGNC__58__4341">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GLUL</p>
-            <p>ENSG: ENSG00000135821</p>
-            <p>HGNC ID: HGNC:4341</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21016" fbc:name="G_HGNC:21016" fbc:label="G_HGNC__58__21016">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LGSN</p>
-            <p>ENSG: ENSG00000146166</p>
-            <p>HGNC ID: HGNC:21016</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10988" fbc:name="G_HGNC:10988" fbc:label="G_HGNC__58__10988">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A18</p>
-            <p>ENSG: ENSG00000182902</p>
-            <p>HGNC ID: HGNC:10988</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19954" fbc:name="G_HGNC:19954" fbc:label="G_HGNC__58__19954">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A22</p>
-            <p>ENSG: ENSG00000177542</p>
-            <p>HGNC ID: HGNC:19954</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__29570" fbc:name="G_HGNC:29570" fbc:label="G_HGNC__58__29570">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GLS2</p>
-            <p>ENSG: ENSG00000135423</p>
-            <p>HGNC ID: HGNC:29570</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9238" fbc:name="G_HGNC:9238" fbc:label="G_HGNC__58__9238">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PPAT</p>
-            <p>ENSG: ENSG00000128059</p>
-            <p>HGNC ID: HGNC:9238</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4163" fbc:name="G_HGNC:4163" fbc:label="G_HGNC__58__4163">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GART</p>
-            <p>ENSG: ENSG00000159131</p>
-            <p>HGNC ID: HGNC:4163</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8863" fbc:name="G_HGNC:8863" fbc:label="G_HGNC__58__8863">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PFAS</p>
-            <p>ENSG: ENSG00000178921</p>
-            <p>HGNC ID: HGNC:8863</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8587" fbc:name="G_HGNC:8587" fbc:label="G_HGNC__58__8587">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PAICS</p>
-            <p>ENSG: ENSG00000128050</p>
-            <p>HGNC ID: HGNC:8587</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__291" fbc:name="G_HGNC:291" fbc:label="G_HGNC__58__291">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ADSL</p>
-            <p>ENSG: ENSG00000239900</p>
-            <p>HGNC ID: HGNC:291</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__794" fbc:name="G_HGNC:794" fbc:label="G_HGNC__58__794">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ATIC</p>
-            <p>ENSG: ENSG00000138363</p>
-            <p>HGNC ID: HGNC:794</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20093" fbc:name="G_HGNC:20093" fbc:label="G_HGNC__58__20093">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ADSS1</p>
-            <p>ENSG: ENSG00000185100</p>
-            <p>HGNC ID: HGNC:20093</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__292" fbc:name="G_HGNC:292" fbc:label="G_HGNC__58__292">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ADSS2</p>
-            <p>ENSG: ENSG00000035687</p>
-            <p>HGNC ID: HGNC:292</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4693" fbc:name="G_HGNC:4693" fbc:label="G_HGNC__58__4693">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GUK1</p>
-            <p>ENSG: ENSG00000143774</p>
-            <p>HGNC ID: HGNC:4693</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17296" fbc:name="G_HGNC:17296" fbc:label="G_HGNC__58__17296">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RRM2B</p>
-            <p>ENSG: ENSG00000048392</p>
-            <p>HGNC ID: HGNC:17296</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10452" fbc:name="G_HGNC:10452" fbc:label="G_HGNC__58__10452">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RRM2</p>
-            <p>ENSG: ENSG00000171848</p>
-            <p>HGNC ID: HGNC:10452</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10451" fbc:name="G_HGNC:10451" fbc:label="G_HGNC__58__10451">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: RRM1</p>
-            <p>ENSG: ENSG00000167325</p>
-            <p>HGNC ID: HGNC:10451</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20091" fbc:name="G_HGNC:20091" fbc:label="G_HGNC__58__20091">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AK7</p>
-            <p>ENSG: ENSG00000140057</p>
-            <p>HGNC ID: HGNC:20091</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__365" fbc:name="G_HGNC:365" fbc:label="G_HGNC__58__365">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AK5</p>
-            <p>ENSG: ENSG00000154027</p>
-            <p>HGNC ID: HGNC:365</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__361" fbc:name="G_HGNC:361" fbc:label="G_HGNC__58__361">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AK1</p>
-            <p>ENSG: ENSG00000106992</p>
-            <p>HGNC ID: HGNC:361</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__362" fbc:name="G_HGNC:362" fbc:label="G_HGNC__58__362">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AK2</p>
-            <p>ENSG: ENSG00000004455</p>
-            <p>HGNC ID: HGNC:362</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1424" fbc:name="G_HGNC:1424" fbc:label="G_HGNC__58__1424">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CAD</p>
-            <p>ENSG: ENSG00000084774</p>
-            <p>HGNC ID: HGNC:1424</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2867" fbc:name="G_HGNC:2867" fbc:label="G_HGNC__58__2867">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DHODH</p>
-            <p>ENSG: ENSG00000102967</p>
-            <p>HGNC ID: HGNC:2867</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12563" fbc:name="G_HGNC:12563" fbc:label="G_HGNC__58__12563">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: UMPS</p>
-            <p>ENSG: ENSG00000114491</p>
-            <p>HGNC ID: HGNC:12563</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18170" fbc:name="G_HGNC:18170" fbc:label="G_HGNC__58__18170">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CMPK1</p>
-            <p>ENSG: ENSG00000162368</p>
-            <p>HGNC ID: HGNC:18170</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12441" fbc:name="G_HGNC:12441" fbc:label="G_HGNC__58__12441">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TYMS</p>
-            <p>ENSG: ENSG00000176890</p>
-            <p>HGNC ID: HGNC:12441</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3061" fbc:name="G_HGNC:3061" fbc:label="G_HGNC__58__3061">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DTYMK</p>
-            <p>ENSG: ENSG00000168393</p>
-            <p>HGNC ID: HGNC:3061</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20461" fbc:name="G_HGNC:20461" fbc:label="G_HGNC__58__20461">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NME7</p>
-            <p>ENSG: ENSG00000143156</p>
-            <p>HGNC ID: HGNC:20461</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20567" fbc:name="G_HGNC:20567" fbc:label="G_HGNC__58__20567">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NME6</p>
-            <p>ENSG: ENSG00000172113</p>
-            <p>HGNC ID: HGNC:20567</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7851" fbc:name="G_HGNC:7851" fbc:label="G_HGNC__58__7851">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NME3</p>
-            <p>ENSG: ENSG00000103024</p>
-            <p>HGNC ID: HGNC:7851</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7850" fbc:name="G_HGNC:7850" fbc:label="G_HGNC__58__7850">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NME2</p>
-            <p>ENSG: ENSG00000243678</p>
-            <p>HGNC ID: HGNC:7850</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7849" fbc:name="G_HGNC:7849" fbc:label="G_HGNC__58__7849">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NME1</p>
-            <p>ENSG: ENSG00000239672</p>
-            <p>HGNC ID: HGNC:7849</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2519" fbc:name="G_HGNC:2519" fbc:label="G_HGNC__58__2519">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CTPS1</p>
-            <p>ENSG: ENSG00000171793</p>
-            <p>HGNC ID: HGNC:2519</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2520" fbc:name="G_HGNC:2520" fbc:label="G_HGNC__58__2520">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CTPS2</p>
-            <p>ENSG: ENSG00000047230</p>
-            <p>HGNC ID: HGNC:2520</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4335" fbc:name="G_HGNC:4335" fbc:label="G_HGNC__58__4335">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GLUD1</p>
-            <p>ENSG: ENSG00000148672</p>
-            <p>HGNC ID: HGNC:4335</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4336" fbc:name="G_HGNC:4336" fbc:label="G_HGNC__58__4336">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GLUD2</p>
-            <p>ENSG: ENSG00000182890</p>
-            <p>HGNC ID: HGNC:4336</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4432" fbc:name="G_HGNC:4432" fbc:label="G_HGNC__58__4432">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GOT1</p>
-            <p>ENSG: ENSG00000120053</p>
-            <p>HGNC ID: HGNC:4432</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4433" fbc:name="G_HGNC:4433" fbc:label="G_HGNC__58__4433">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GOT2</p>
-            <p>ENSG: ENSG00000125166</p>
-            <p>HGNC ID: HGNC:4433</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10982" fbc:name="G_HGNC:10982" fbc:label="G_HGNC__58__10982">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A12</p>
-            <p>ENSG: ENSG00000115840</p>
-            <p>HGNC ID: HGNC:10982</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10983" fbc:name="G_HGNC:10983" fbc:label="G_HGNC__58__10983">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A13</p>
-            <p>ENSG: ENSG00000004864</p>
-            <p>HGNC ID: HGNC:10983</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2323" fbc:name="G_HGNC:2323" fbc:label="G_HGNC__58__2323">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CPS1</p>
-            <p>ENSG: ENSG00000021826</p>
-            <p>HGNC ID: HGNC:2323</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8512" fbc:name="G_HGNC:8512" fbc:label="G_HGNC__58__8512">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: OTC</p>
-            <p>ENSG: ENSG00000036473</p>
-            <p>HGNC ID: HGNC:8512</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10985" fbc:name="G_HGNC:10985" fbc:label="G_HGNC__58__10985">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A15</p>
-            <p>ENSG: ENSG00000102743</p>
-            <p>HGNC ID: HGNC:10985</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__22921" fbc:name="G_HGNC:22921" fbc:label="G_HGNC__58__22921">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A2</p>
-            <p>ENSG: ENSG00000120329</p>
-            <p>HGNC ID: HGNC:22921</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__758" fbc:name="G_HGNC:758" fbc:label="G_HGNC__58__758">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ASS1</p>
-            <p>ENSG: ENSG00000130707</p>
-            <p>HGNC ID: HGNC:758</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__746" fbc:name="G_HGNC:746" fbc:label="G_HGNC__58__746">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ASL</p>
-            <p>ENSG: ENSG00000126522</p>
-            <p>HGNC ID: HGNC:746</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__663" fbc:name="G_HGNC:663" fbc:label="G_HGNC__58__663">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ARG1</p>
-            <p>ENSG: ENSG00000118520</p>
-            <p>HGNC ID: HGNC:663</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8109" fbc:name="G_HGNC:8109" fbc:label="G_HGNC__58__8109">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ODC1</p>
-            <p>ENSG: ENSG00000115758</p>
-            <p>HGNC ID: HGNC:8109</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11296" fbc:name="G_HGNC:11296" fbc:label="G_HGNC__58__11296">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SRM</p>
-            <p>ENSG: ENSG00000116649</p>
-            <p>HGNC ID: HGNC:11296</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11123" fbc:name="G_HGNC:11123" fbc:label="G_HGNC__58__11123">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SMS</p>
-            <p>ENSG: ENSG00000102172</p>
-            <p>HGNC ID: HGNC:11123</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7413" fbc:name="G_HGNC:7413" fbc:label="G_HGNC__58__7413">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTAP</p>
-            <p>ENSG: ENSG00000099810</p>
-            <p>HGNC ID: HGNC:7413</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__626" fbc:name="G_HGNC:626" fbc:label="G_HGNC__58__626">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: APRT</p>
-            <p>ENSG: ENSG00000198931</p>
-            <p>HGNC ID: HGNC:626</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__633" fbc:name="G_HGNC:633" fbc:label="G_HGNC__58__633">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AQP1</p>
-            <p>ENSG: ENSG00000240583</p>
-            <p>HGNC ID: HGNC:633</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__634" fbc:name="G_HGNC:634" fbc:label="G_HGNC__58__634">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AQP2</p>
-            <p>ENSG: ENSG00000167580</p>
-            <p>HGNC ID: HGNC:634</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__638" fbc:name="G_HGNC:638" fbc:label="G_HGNC__58__638">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AQP5</p>
-            <p>ENSG: ENSG00000161798</p>
-            <p>HGNC ID: HGNC:638</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__637" fbc:name="G_HGNC:637" fbc:label="G_HGNC__58__637">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AQP4</p>
-            <p>ENSG: ENSG00000171885</p>
-            <p>HGNC ID: HGNC:637</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7103" fbc:name="G_HGNC:7103" fbc:label="G_HGNC__58__7103">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MIP</p>
-            <p>ENSG: ENSG00000135517</p>
-            <p>HGNC ID: HGNC:7103</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4175" fbc:name="G_HGNC:4175" fbc:label="G_HGNC__58__4175">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GATM</p>
-            <p>ENSG: ENSG00000171766</p>
-            <p>HGNC ID: HGNC:4175</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__406" fbc:name="G_HGNC:406" fbc:label="G_HGNC__58__406">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH4A1</p>
-            <p>ENSG: ENSG00000159423</p>
-            <p>HGNC ID: HGNC:406</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30262" fbc:name="G_HGNC:30262" fbc:label="G_HGNC__58__30262">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PYCR2</p>
-            <p>ENSG: ENSG00000143811</p>
-            <p>HGNC ID: HGNC:30262</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17325" fbc:name="G_HGNC:17325" fbc:label="G_HGNC__58__17325">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PRODH2</p>
-            <p>ENSG: ENSG00000250799</p>
-            <p>HGNC ID: HGNC:17325</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__753" fbc:name="G_HGNC:753" fbc:label="G_HGNC__58__753">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ASNS</p>
-            <p>ENSG: ENSG00000070669</p>
-            <p>HGNC ID: HGNC:753</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16448" fbc:name="G_HGNC:16448" fbc:label="G_HGNC__58__16448">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ASRGL1</p>
-            <p>ENSG: ENSG00000162174</p>
-            <p>HGNC ID: HGNC:16448</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20123" fbc:name="G_HGNC:20123" fbc:label="G_HGNC__58__20123">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ASPG</p>
-            <p>ENSG: ENSG00000166183</p>
-            <p>HGNC ID: HGNC:20123</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7468" fbc:name="G_HGNC:7468" fbc:label="G_HGNC__58__7468">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTR</p>
-            <p>ENSG: ENSG00000116984</p>
-            <p>HGNC ID: HGNC:7468</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6904" fbc:name="G_HGNC:6904" fbc:label="G_HGNC__58__6904">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MAT2A</p>
-            <p>ENSG: ENSG00000168906</p>
-            <p>HGNC ID: HGNC:6904</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6905" fbc:name="G_HGNC:6905" fbc:label="G_HGNC__58__6905">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MAT2B</p>
-            <p>ENSG: ENSG00000038274</p>
-            <p>HGNC ID: HGNC:6905</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6903" fbc:name="G_HGNC:6903" fbc:label="G_HGNC__58__6903">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MAT1A</p>
-            <p>ENSG: ENSG00000151224</p>
-            <p>HGNC ID: HGNC:6903</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__257" fbc:name="G_HGNC:257" fbc:label="G_HGNC__58__257">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ADK</p>
-            <p>ENSG: ENSG00000156110</p>
-            <p>HGNC ID: HGNC:257</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1550" fbc:name="G_HGNC:1550" fbc:label="G_HGNC__58__1550">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CBS</p>
-            <p>ENSG: ENSG00000160200</p>
-            <p>HGNC ID: HGNC:1550</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2501" fbc:name="G_HGNC:2501" fbc:label="G_HGNC__58__2501">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CTH</p>
-            <p>ENSG: ENSG00000116761</p>
-            <p>HGNC ID: HGNC:2501</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7436" fbc:name="G_HGNC:7436" fbc:label="G_HGNC__58__7436">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTHFR</p>
-            <p>ENSG: ENSG00000177000</p>
-            <p>HGNC ID: HGNC:7436</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3791" fbc:name="G_HGNC:3791" fbc:label="G_HGNC__58__3791">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FOLR1</p>
-            <p>ENSG: ENSG00000110195</p>
-            <p>HGNC ID: HGNC:3791</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3795" fbc:name="G_HGNC:3795" fbc:label="G_HGNC__58__3795">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FOLR3</p>
-            <p>ENSG: ENSG00000110203</p>
-            <p>HGNC ID: HGNC:3795</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__976" fbc:name="G_HGNC:976" fbc:label="G_HGNC__58__976">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: BCAT1</p>
-            <p>ENSG: ENSG00000060982</p>
-            <p>HGNC ID: HGNC:976</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__977" fbc:name="G_HGNC:977" fbc:label="G_HGNC__58__977">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: BCAT2</p>
-            <p>ENSG: ENSG00000105552</p>
-            <p>HGNC ID: HGNC:977</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__986" fbc:name="G_HGNC:986" fbc:label="G_HGNC__58__986">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: BCKDHA</p>
-            <p>ENSG: ENSG00000248098</p>
-            <p>HGNC ID: HGNC:986</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2698" fbc:name="G_HGNC:2698" fbc:label="G_HGNC__58__2698">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DBT</p>
-            <p>ENSG: ENSG00000137992</p>
-            <p>HGNC ID: HGNC:2698</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__987" fbc:name="G_HGNC:987" fbc:label="G_HGNC__58__987">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: BCKDHB</p>
-            <p>ENSG: ENSG00000083123</p>
-            <p>HGNC ID: HGNC:987</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6186" fbc:name="G_HGNC:6186" fbc:label="G_HGNC__58__6186">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IVD</p>
-            <p>ENSG: ENSG00000128928</p>
-            <p>HGNC ID: HGNC:6186</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6937" fbc:name="G_HGNC:6937" fbc:label="G_HGNC__58__6937">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MCCC2</p>
-            <p>ENSG: ENSG00000131844</p>
-            <p>HGNC ID: HGNC:6937</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6936" fbc:name="G_HGNC:6936" fbc:label="G_HGNC__58__6936">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MCCC1</p>
-            <p>ENSG: ENSG00000078070</p>
-            <p>HGNC ID: HGNC:6936</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__890" fbc:name="G_HGNC:890" fbc:label="G_HGNC__58__890">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AUH</p>
-            <p>ENSG: ENSG00000148090</p>
-            <p>HGNC ID: HGNC:890</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__87" fbc:name="G_HGNC:87" fbc:label="G_HGNC__58__87">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACAD8</p>
-            <p>ENSG: ENSG00000151498</p>
-            <p>HGNC ID: HGNC:87</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__89" fbc:name="G_HGNC:89" fbc:label="G_HGNC__58__89">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACADM</p>
-            <p>ENSG: ENSG00000117054</p>
-            <p>HGNC ID: HGNC:89</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4801" fbc:name="G_HGNC:4801" fbc:label="G_HGNC__58__4801">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HADHA</p>
-            <p>ENSG: ENSG00000084754</p>
-            <p>HGNC ID: HGNC:4801</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4803" fbc:name="G_HGNC:4803" fbc:label="G_HGNC__58__4803">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HADHB</p>
-            <p>ENSG: ENSG00000138029</p>
-            <p>HGNC ID: HGNC:4803</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3151" fbc:name="G_HGNC:3151" fbc:label="G_HGNC__58__3151">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ECHS1</p>
-            <p>ENSG: ENSG00000127884</p>
-            <p>HGNC ID: HGNC:3151</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4907" fbc:name="G_HGNC:4907" fbc:label="G_HGNC__58__4907">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HIBADH</p>
-            <p>ENSG: ENSG00000106049</p>
-            <p>HGNC ID: HGNC:4907</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__407" fbc:name="G_HGNC:407" fbc:label="G_HGNC__58__407">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH1B1</p>
-            <p>ENSG: ENSG00000137124</p>
-            <p>HGNC ID: HGNC:407</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__412" fbc:name="G_HGNC:412" fbc:label="G_HGNC__58__412">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH9A1</p>
-            <p>ENSG: ENSG00000143149</p>
-            <p>HGNC ID: HGNC:412</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__877" fbc:name="G_HGNC:877" fbc:label="G_HGNC__58__877">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH7A1</p>
-            <p>ENSG: ENSG00000164904</p>
-            <p>HGNC ID: HGNC:877</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__404" fbc:name="G_HGNC:404" fbc:label="G_HGNC__58__404">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH2</p>
-            <p>ENSG: ENSG00000111275</p>
-            <p>HGNC ID: HGNC:404</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__403" fbc:name="G_HGNC:403" fbc:label="G_HGNC__58__403">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH3A2</p>
-            <p>ENSG: ENSG00000072210</p>
-            <p>HGNC ID: HGNC:403</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7179" fbc:name="G_HGNC:7179" fbc:label="G_HGNC__58__7179">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH6A1</p>
-            <p>ENSG: ENSG00000119711</p>
-            <p>HGNC ID: HGNC:7179</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16732" fbc:name="G_HGNC:16732" fbc:label="G_HGNC__58__16732">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MCEE</p>
-            <p>ENSG: ENSG00000124370</p>
-            <p>HGNC ID: HGNC:16732</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7526" fbc:name="G_HGNC:7526" fbc:label="G_HGNC__58__7526">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MMUT</p>
-            <p>ENSG: ENSG00000146085</p>
-            <p>HGNC ID: HGNC:7526</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8923" fbc:name="G_HGNC:8923" fbc:label="G_HGNC__58__8923">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PHGDH</p>
-            <p>ENSG: ENSG00000092621</p>
-            <p>HGNC ID: HGNC:8923</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19129" fbc:name="G_HGNC:19129" fbc:label="G_HGNC__58__19129">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PSAT1</p>
-            <p>ENSG: ENSG00000135069</p>
-            <p>HGNC ID: HGNC:19129</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9577" fbc:name="G_HGNC:9577" fbc:label="G_HGNC__58__9577">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PSPH</p>
-            <p>ENSG: ENSG00000146733</p>
-            <p>HGNC ID: HGNC:9577</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10850" fbc:name="G_HGNC:10850" fbc:label="G_HGNC__58__10850">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SHMT1</p>
-            <p>ENSG: ENSG00000176974</p>
-            <p>HGNC ID: HGNC:10850</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30404" fbc:name="G_HGNC:30404" fbc:label="G_HGNC__58__30404">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDSL</p>
-            <p>ENSG: ENSG00000139410</p>
-            <p>HGNC ID: HGNC:30404</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10691" fbc:name="G_HGNC:10691" fbc:label="G_HGNC__58__10691">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SDS</p>
-            <p>ENSG: ENSG00000135094</p>
-            <p>HGNC ID: HGNC:10691</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4552" fbc:name="G_HGNC:4552" fbc:label="G_HGNC__58__4552">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPT</p>
-            <p>ENSG: ENSG00000167701</p>
-            <p>HGNC ID: HGNC:4552</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18062" fbc:name="G_HGNC:18062" fbc:label="G_HGNC__58__18062">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPT2</p>
-            <p>ENSG: ENSG00000166123</p>
-            <p>HGNC ID: HGNC:18062</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10852" fbc:name="G_HGNC:10852" fbc:label="G_HGNC__58__10852">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SHMT2</p>
-            <p>ENSG: ENSG00000182199</p>
-            <p>HGNC ID: HGNC:10852</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__29683" fbc:name="G_HGNC:29683" fbc:label="G_HGNC__58__29683">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A32</p>
-            <p>ENSG: ENSG00000164933</p>
-            <p>HGNC ID: HGNC:29683</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2861" fbc:name="G_HGNC:2861" fbc:label="G_HGNC__58__2861">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DHFR</p>
-            <p>ENSG: ENSG00000228716</p>
-            <p>HGNC ID: HGNC:2861</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21055" fbc:name="G_HGNC:21055" fbc:label="G_HGNC__58__21055">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTHFD1L</p>
-            <p>ENSG: ENSG00000120254</p>
-            <p>HGNC ID: HGNC:21055</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7432" fbc:name="G_HGNC:7432" fbc:label="G_HGNC__58__7432">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTHFD1</p>
-            <p>ENSG: ENSG00000100714</p>
-            <p>HGNC ID: HGNC:7432</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7434" fbc:name="G_HGNC:7434" fbc:label="G_HGNC__58__7434">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTHFD2</p>
-            <p>ENSG: ENSG00000065911</p>
-            <p>HGNC ID: HGNC:7434</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__26777" fbc:name="G_HGNC:26777" fbc:label="G_HGNC__58__26777">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH1L2</p>
-            <p>ENSG: ENSG00000136010</p>
-            <p>HGNC ID: HGNC:26777</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3978" fbc:name="G_HGNC:3978" fbc:label="G_HGNC__58__3978">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ALDH1L1</p>
-            <p>ENSG: ENSG00000144908</p>
-            <p>HGNC ID: HGNC:3978</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__31865" fbc:name="G_HGNC:31865" fbc:label="G_HGNC__58__31865">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MTHFD2L</p>
-            <p>ENSG: ENSG00000163738</p>
-            <p>HGNC ID: HGNC:31865</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__94" fbc:name="G_HGNC:94" fbc:label="G_HGNC__58__94">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACAT2</p>
-            <p>ENSG: ENSG00000120437</p>
-            <p>HGNC ID: HGNC:94</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5007" fbc:name="G_HGNC:5007" fbc:label="G_HGNC__58__5007">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HMGCS1</p>
-            <p>ENSG: ENSG00000112972</p>
-            <p>HGNC ID: HGNC:5007</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__85" fbc:name="G_HGNC:85" fbc:label="G_HGNC__58__85">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACACB</p>
-            <p>ENSG: ENSG00000076555</p>
-            <p>HGNC ID: HGNC:85</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__84" fbc:name="G_HGNC:84" fbc:label="G_HGNC__58__84">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACACA</p>
-            <p>ENSG: ENSG00000278540</p>
-            <p>HGNC ID: HGNC:84</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3594" fbc:name="G_HGNC:3594" fbc:label="G_HGNC__58__3594">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FASN</p>
-            <p>ENSG: ENSG00000169710</p>
-            <p>HGNC ID: HGNC:3594</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3569" fbc:name="G_HGNC:3569" fbc:label="G_HGNC__58__3569">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACSL1</p>
-            <p>ENSG: ENSG00000151726</p>
-            <p>HGNC ID: HGNC:3569</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3570" fbc:name="G_HGNC:3570" fbc:label="G_HGNC__58__3570">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACSL3</p>
-            <p>ENSG: ENSG00000123983</p>
-            <p>HGNC ID: HGNC:3570</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3571" fbc:name="G_HGNC:3571" fbc:label="G_HGNC__58__3571">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACSL4</p>
-            <p>ENSG: ENSG00000068366</p>
-            <p>HGNC ID: HGNC:3571</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16496" fbc:name="G_HGNC:16496" fbc:label="G_HGNC__58__16496">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACSL6</p>
-            <p>ENSG: ENSG00000164398</p>
-            <p>HGNC ID: HGNC:16496</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18540" fbc:name="G_HGNC:18540" fbc:label="G_HGNC__58__18540">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CPT1C</p>
-            <p>ENSG: ENSG00000169169</p>
-            <p>HGNC ID: HGNC:18540</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2329" fbc:name="G_HGNC:2329" fbc:label="G_HGNC__58__2329">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CPT1B</p>
-            <p>ENSG: ENSG00000205560</p>
-            <p>HGNC ID: HGNC:2329</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2328" fbc:name="G_HGNC:2328" fbc:label="G_HGNC__58__2328">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CPT1A</p>
-            <p>ENSG: ENSG00000110090</p>
-            <p>HGNC ID: HGNC:2328</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1421" fbc:name="G_HGNC:1421" fbc:label="G_HGNC__58__1421">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A20</p>
-            <p>ENSG: ENSG00000178537</p>
-            <p>HGNC ID: HGNC:1421</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2330" fbc:name="G_HGNC:2330" fbc:label="G_HGNC__58__2330">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CPT2</p>
-            <p>ENSG: ENSG00000157184</p>
-            <p>HGNC ID: HGNC:2330</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__88" fbc:name="G_HGNC:88" fbc:label="G_HGNC__58__88">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACADL</p>
-            <p>ENSG: ENSG00000115361</p>
-            <p>HGNC ID: HGNC:88</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__83" fbc:name="G_HGNC:83" fbc:label="G_HGNC__58__83">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACAA2</p>
-            <p>ENSG: ENSG00000167315</p>
-            <p>HGNC ID: HGNC:83</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__92" fbc:name="G_HGNC:92" fbc:label="G_HGNC__58__92">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACADVL</p>
-            <p>ENSG: ENSG00000072778</p>
-            <p>HGNC ID: HGNC:92</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13444" fbc:name="G_HGNC:13444" fbc:label="G_HGNC__58__13444">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A10</p>
-            <p>ENSG: ENSG00000197496</p>
-            <p>HGNC ID: HGNC:13444</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23155" fbc:name="G_HGNC:23155" fbc:label="G_HGNC__58__23155">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A10</p>
-            <p>ENSG: ENSG00000154025</p>
-            <p>HGNC ID: HGNC:23155</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11010" fbc:name="G_HGNC:11010" fbc:label="G_HGNC__58__11010">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A5</p>
-            <p>ENSG: ENSG00000142583</p>
-            <p>HGNC ID: HGNC:11010</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__15956" fbc:name="G_HGNC:15956" fbc:label="G_HGNC__58__15956">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A13</p>
-            <p>ENSG: ENSG00000151229</p>
-            <p>HGNC ID: HGNC:15956</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__22146" fbc:name="G_HGNC:22146" fbc:label="G_HGNC__58__22146">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A9</p>
-            <p>ENSG: ENSG00000117834</p>
-            <p>HGNC ID: HGNC:22146</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11038" fbc:name="G_HGNC:11038" fbc:label="G_HGNC__58__11038">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A3</p>
-            <p>ENSG: ENSG00000198743</p>
-            <p>HGNC ID: HGNC:11038</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18301" fbc:name="G_HGNC:18301" fbc:label="G_HGNC__58__18301">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A14</p>
-            <p>ENSG: ENSG00000173262</p>
-            <p>HGNC ID: HGNC:18301</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14025" fbc:name="G_HGNC:14025" fbc:label="G_HGNC__58__14025">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A7</p>
-            <p>ENSG: ENSG00000115665</p>
-            <p>HGNC ID: HGNC:14025</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11039" fbc:name="G_HGNC:11039" fbc:label="G_HGNC__58__11039">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A4</p>
-            <p>ENSG: ENSG00000100191</p>
-            <p>HGNC ID: HGNC:11039</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11011" fbc:name="G_HGNC:11011" fbc:label="G_HGNC__58__11011">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A6</p>
-            <p>ENSG: ENSG00000160326</p>
-            <p>HGNC ID: HGNC:11011</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11040" fbc:name="G_HGNC:11040" fbc:label="G_HGNC__58__11040">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A5</p>
-            <p>ENSG: ENSG00000105641</p>
-            <p>HGNC ID: HGNC:11040</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14239" fbc:name="G_HGNC:14239" fbc:label="G_HGNC__58__14239">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A11</p>
-            <p>ENSG: ENSG00000133460</p>
-            <p>HGNC ID: HGNC:14239</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11007" fbc:name="G_HGNC:11007" fbc:label="G_HGNC__58__11007">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A3</p>
-            <p>ENSG: ENSG00000059804</p>
-            <p>HGNC ID: HGNC:11007</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11041" fbc:name="G_HGNC:11041" fbc:label="G_HGNC__58__11041">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A6</p>
-            <p>ENSG: ENSG00000138074</p>
-            <p>HGNC ID: HGNC:11041</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13446" fbc:name="G_HGNC:13446" fbc:label="G_HGNC__58__13446">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A9</p>
-            <p>ENSG: ENSG00000109667</p>
-            <p>HGNC ID: HGNC:13446</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11036" fbc:name="G_HGNC:11036" fbc:label="G_HGNC__58__11036">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A1</p>
-            <p>ENSG: ENSG00000100170</p>
-            <p>HGNC ID: HGNC:11036</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23091" fbc:name="G_HGNC:23091" fbc:label="G_HGNC__58__23091">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A11</p>
-            <p>ENSG: ENSG00000158865</p>
-            <p>HGNC ID: HGNC:23091</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18067" fbc:name="G_HGNC:18067" fbc:label="G_HGNC__58__18067">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A12</p>
-            <p>ENSG: ENSG00000146411</p>
-            <p>HGNC ID: HGNC:18067</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__28750" fbc:name="G_HGNC:28750" fbc:label="G_HGNC__58__28750">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A12</p>
-            <p>ENSG: ENSG00000148942</p>
-            <p>HGNC ID: HGNC:28750</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19119" fbc:name="G_HGNC:19119" fbc:label="G_HGNC__58__19119">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A8</p>
-            <p>ENSG: ENSG00000256870</p>
-            <p>HGNC ID: HGNC:19119</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13812" fbc:name="G_HGNC:13812" fbc:label="G_HGNC__58__13812">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A8</p>
-            <p>ENSG: ENSG00000136856</p>
-            <p>HGNC ID: HGNC:13812</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11005" fbc:name="G_HGNC:11005" fbc:label="G_HGNC__58__11005">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A1</p>
-            <p>ENSG: ENSG00000117394</p>
-            <p>HGNC ID: HGNC:11005</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11037" fbc:name="G_HGNC:11037" fbc:label="G_HGNC__58__11037">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC5A2</p>
-            <p>ENSG: ENSG00000140675</p>
-            <p>HGNC ID: HGNC:11037</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13445" fbc:name="G_HGNC:13445" fbc:label="G_HGNC__58__13445">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A7</p>
-            <p>ENSG: ENSG00000197241</p>
-            <p>HGNC ID: HGNC:13445</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11006" fbc:name="G_HGNC:11006" fbc:label="G_HGNC__58__11006">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A2</p>
-            <p>ENSG: ENSG00000163581</p>
-            <p>HGNC ID: HGNC:11006</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11009" fbc:name="G_HGNC:11009" fbc:label="G_HGNC__58__11009">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC2A4</p>
-            <p>ENSG: ENSG00000181856</p>
-            <p>HGNC ID: HGNC:11009</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14679" fbc:name="G_HGNC:14679" fbc:label="G_HGNC__58__14679">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC38A4</p>
-            <p>ENSG: ENSG00000139209</p>
-            <p>HGNC ID: HGNC:14679</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18070" fbc:name="G_HGNC:18070" fbc:label="G_HGNC__58__18070">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC38A5</p>
-            <p>ENSG: ENSG00000017483</p>
-            <p>HGNC ID: HGNC:18070</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__26441" fbc:name="G_HGNC:26441" fbc:label="G_HGNC__58__26441">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A18</p>
-            <p>ENSG: ENSG00000164363</p>
-            <p>HGNC ID: HGNC:26441</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13447" fbc:name="G_HGNC:13447" fbc:label="G_HGNC__58__13447">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC38A1</p>
-            <p>ENSG: ENSG00000111371</p>
-            <p>HGNC ID: HGNC:13447</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__29437" fbc:name="G_HGNC:29437" fbc:label="G_HGNC__58__29437">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CLTRN</p>
-            <p>ENSG: ENSG00000147003</p>
-            <p>HGNC ID: HGNC:29437</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11047" fbc:name="G_HGNC:11047" fbc:label="G_HGNC__58__11047">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A14</p>
-            <p>ENSG: ENSG00000268104</p>
-            <p>HGNC ID: HGNC:11047</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__27960" fbc:name="G_HGNC:27960" fbc:label="G_HGNC__58__27960">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A19</p>
-            <p>ENSG: ENSG00000174358</p>
-            <p>HGNC ID: HGNC:27960</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13448" fbc:name="G_HGNC:13448" fbc:label="G_HGNC__58__13448">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC38A2</p>
-            <p>ENSG: ENSG00000134294</p>
-            <p>HGNC ID: HGNC:13448</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18044" fbc:name="G_HGNC:18044" fbc:label="G_HGNC__58__18044">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC38A3</p>
-            <p>ENSG: ENSG00000188338</p>
-            <p>HGNC ID: HGNC:18044</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9225" fbc:name="G_HGNC:9225" fbc:label="G_HGNC__58__9225">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC43A1</p>
-            <p>ENSG: ENSG00000149150</p>
-            <p>HGNC ID: HGNC:9225</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3793" fbc:name="G_HGNC:3793" fbc:label="G_HGNC__58__3793">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FOLR2</p>
-            <p>ENSG: ENSG00000165457</p>
-            <p>HGNC ID: HGNC:3793</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11060" fbc:name="G_HGNC:11060" fbc:label="G_HGNC__58__11060">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A2</p>
-            <p>ENSG: ENSG00000003989</p>
-            <p>HGNC ID: HGNC:11060</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11061" fbc:name="G_HGNC:11061" fbc:label="G_HGNC__58__11061">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A3</p>
-            <p>ENSG: ENSG00000165349</p>
-            <p>HGNC ID: HGNC:11061</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11057" fbc:name="G_HGNC:11057" fbc:label="G_HGNC__58__11057">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A1</p>
-            <p>ENSG: ENSG00000139514</p>
-            <p>HGNC ID: HGNC:11057</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17027" fbc:name="G_HGNC:17027" fbc:label="G_HGNC__58__17027">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC16A10</p>
-            <p>ENSG: ENSG00000112394</p>
-            <p>HGNC ID: HGNC:17027</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18761" fbc:name="G_HGNC:18761" fbc:label="G_HGNC__58__18761">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC36A1</p>
-            <p>ENSG: ENSG00000123643</p>
-            <p>HGNC ID: HGNC:18761</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13557" fbc:name="G_HGNC:13557" fbc:label="G_HGNC__58__13557">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACE2</p>
-            <p>ENSG: ENSG00000130234</p>
-            <p>HGNC ID: HGNC:13557</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11056" fbc:name="G_HGNC:11056" fbc:label="G_HGNC__58__11056">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A9</p>
-            <p>ENSG: ENSG00000196517</p>
-            <p>HGNC ID: HGNC:11056</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18762" fbc:name="G_HGNC:18762" fbc:label="G_HGNC__58__18762">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC36A2</p>
-            <p>ENSG: ENSG00000186335</p>
-            <p>HGNC ID: HGNC:18762</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11051" fbc:name="G_HGNC:11051" fbc:label="G_HGNC__58__11051">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A5</p>
-            <p>ENSG: ENSG00000165970</p>
-            <p>HGNC ID: HGNC:11051</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1663" fbc:name="G_HGNC:1663" fbc:label="G_HGNC__58__1663">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CD36</p>
-            <p>ENSG: ENSG00000135218</p>
-            <p>HGNC ID: HGNC:1663</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10995" fbc:name="G_HGNC:10995" fbc:label="G_HGNC__58__10995">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC27A1</p>
-            <p>ENSG: ENSG00000130304</p>
-            <p>HGNC ID: HGNC:10995</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10998" fbc:name="G_HGNC:10998" fbc:label="G_HGNC__58__10998">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC27A4</p>
-            <p>ENSG: ENSG00000167114</p>
-            <p>HGNC ID: HGNC:10998</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10969" fbc:name="G_HGNC:10969" fbc:label="G_HGNC__58__10969">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC22A5</p>
-            <p>ENSG: ENSG00000197375</p>
-            <p>HGNC ID: HGNC:10969</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10924" fbc:name="G_HGNC:10924" fbc:label="G_HGNC__58__10924">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC16A3</p>
-            <p>ENSG: ENSG00000141526</p>
-            <p>HGNC ID: HGNC:10924</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16270" fbc:name="G_HGNC:16270" fbc:label="G_HGNC__58__16270">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC16A8</p>
-            <p>ENSG: ENSG00000100156</p>
-            <p>HGNC ID: HGNC:16270</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10928" fbc:name="G_HGNC:10928" fbc:label="G_HGNC__58__10928">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC16A7</p>
-            <p>ENSG: ENSG00000118596</p>
-            <p>HGNC ID: HGNC:10928</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10919" fbc:name="G_HGNC:10919" fbc:label="G_HGNC__58__10919">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC14A2</p>
-            <p>ENSG: ENSG00000132874</p>
-            <p>HGNC ID: HGNC:10919</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10918" fbc:name="G_HGNC:10918" fbc:label="G_HGNC__58__10918">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC14A1</p>
-            <p>ENSG: ENSG00000141469</p>
-            <p>HGNC ID: HGNC:10918</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11004" fbc:name="G_HGNC:11004" fbc:label="G_HGNC__58__11004">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC29A2</p>
-            <p>ENSG: ENSG00000174669</p>
-            <p>HGNC ID: HGNC:11004</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11003" fbc:name="G_HGNC:11003" fbc:label="G_HGNC__58__11003">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC29A1</p>
-            <p>ENSG: ENSG00000112759</p>
-            <p>HGNC ID: HGNC:11003</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19660" fbc:name="G_HGNC:19660" fbc:label="G_HGNC__58__19660">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC36A4</p>
-            <p>ENSG: ENSG00000180773</p>
-            <p>HGNC ID: HGNC:19660</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10941" fbc:name="G_HGNC:10941" fbc:label="G_HGNC__58__10941">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A3</p>
-            <p>ENSG: ENSG00000079215</p>
-            <p>HGNC ID: HGNC:10941</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10944" fbc:name="G_HGNC:10944" fbc:label="G_HGNC__58__10944">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A6</p>
-            <p>ENSG: ENSG00000105143</p>
-            <p>HGNC ID: HGNC:10944</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10945" fbc:name="G_HGNC:10945" fbc:label="G_HGNC__58__10945">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A7</p>
-            <p>ENSG: ENSG00000162383</p>
-            <p>HGNC ID: HGNC:10945</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10939" fbc:name="G_HGNC:10939" fbc:label="G_HGNC__58__10939">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A1</p>
-            <p>ENSG: ENSG00000106688</p>
-            <p>HGNC ID: HGNC:10939</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10940" fbc:name="G_HGNC:10940" fbc:label="G_HGNC__58__10940">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A2</p>
-            <p>ENSG: ENSG00000110436</p>
-            <p>HGNC ID: HGNC:10940</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4136" fbc:name="G_HGNC:4136" fbc:label="G_HGNC__58__4136">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GAMT</p>
-            <p>ENSG: ENSG00000130005</p>
-            <p>HGNC ID: HGNC:4136</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1994" fbc:name="G_HGNC:1994" fbc:label="G_HGNC__58__1994">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CKM</p>
-            <p>ENSG: ENSG00000104879</p>
-            <p>HGNC ID: HGNC:1994</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1991" fbc:name="G_HGNC:1991" fbc:label="G_HGNC__58__1991">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CKB</p>
-            <p>ENSG: ENSG00000166165</p>
-            <p>HGNC ID: HGNC:1991</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__80" fbc:name="G_HGNC:80" fbc:label="G_HGNC__58__80">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AOC1</p>
-            <p>ENSG: ENSG00000002726</p>
-            <p>HGNC ID: HGNC:80</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__549" fbc:name="G_HGNC:549" fbc:label="G_HGNC__58__549">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AOC2</p>
-            <p>ENSG: ENSG00000131480</p>
-            <p>HGNC ID: HGNC:549</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__550" fbc:name="G_HGNC:550" fbc:label="G_HGNC__58__550">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AOC3</p>
-            <p>ENSG: ENSG00000131471</p>
-            <p>HGNC ID: HGNC:550</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4806" fbc:name="G_HGNC:4806" fbc:label="G_HGNC__58__4806">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HAL</p>
-            <p>ENSG: ENSG00000084110</p>
-            <p>HGNC ID: HGNC:4806</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__28577" fbc:name="G_HGNC:28577" fbc:label="G_HGNC__58__28577">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AMDHD1</p>
-            <p>ENSG: ENSG00000139344</p>
-            <p>HGNC ID: HGNC:28577</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3974" fbc:name="G_HGNC:3974" fbc:label="G_HGNC__58__3974">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FTCD</p>
-            <p>ENSG: ENSG00000160282</p>
-            <p>HGNC ID: HGNC:3974</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__29268" fbc:name="G_HGNC:29268" fbc:label="G_HGNC__58__29268">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CARNS1</p>
-            <p>ENSG: ENSG00000172508</p>
-            <p>HGNC ID: HGNC:29268</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4092" fbc:name="G_HGNC:4092" fbc:label="G_HGNC__58__4092">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GAD1</p>
-            <p>ENSG: ENSG00000128683</p>
-            <p>HGNC ID: HGNC:4092</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17366" fbc:name="G_HGNC:17366" fbc:label="G_HGNC__58__17366">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AASS</p>
-            <p>ENSG: ENSG00000008311</p>
-            <p>HGNC ID: HGNC:17366</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__17929" fbc:name="G_HGNC:17929" fbc:label="G_HGNC__58__17929">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AADAT</p>
-            <p>ENSG: ENSG00000109576</p>
-            <p>HGNC ID: HGNC:17929</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4189" fbc:name="G_HGNC:4189" fbc:label="G_HGNC__58__4189">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GCDH</p>
-            <p>ENSG: ENSG00000105607</p>
-            <p>HGNC ID: HGNC:4189</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23408" fbc:name="G_HGNC:23408" fbc:label="G_HGNC__58__23408">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ECHDC2</p>
-            <p>ENSG: ENSG00000121310</p>
-            <p>HGNC ID: HGNC:23408</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5008" fbc:name="G_HGNC:5008" fbc:label="G_HGNC__58__5008">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HMGCS2</p>
-            <p>ENSG: ENSG00000134240</p>
-            <p>HGNC ID: HGNC:5008</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1795" fbc:name="G_HGNC:1795" fbc:label="G_HGNC__58__1795">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CDO1</p>
-            <p>ENSG: ENSG00000129596</p>
-            <p>HGNC ID: HGNC:1795</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11573" fbc:name="G_HGNC:11573" fbc:label="G_HGNC__58__11573">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TAT</p>
-            <p>ENSG: ENSG00000198650</p>
-            <p>HGNC ID: HGNC:11573</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5147" fbc:name="G_HGNC:5147" fbc:label="G_HGNC__58__5147">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HPD</p>
-            <p>ENSG: ENSG00000158104</p>
-            <p>HGNC ID: HGNC:5147</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4892" fbc:name="G_HGNC:4892" fbc:label="G_HGNC__58__4892">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HGD</p>
-            <p>ENSG: ENSG00000113924</p>
-            <p>HGNC ID: HGNC:4892</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4643" fbc:name="G_HGNC:4643" fbc:label="G_HGNC__58__4643">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GSTZ1</p>
-            <p>ENSG: ENSG00000100577</p>
-            <p>HGNC ID: HGNC:4643</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3579" fbc:name="G_HGNC:3579" fbc:label="G_HGNC__58__3579">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FAH</p>
-            <p>ENSG: ENSG00000103876</p>
-            <p>HGNC ID: HGNC:3579</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__21298" fbc:name="G_HGNC:21298" fbc:label="G_HGNC__58__21298">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AACS</p>
-            <p>ENSG: ENSG00000081760</p>
-            <p>HGNC ID: HGNC:21298</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11063" fbc:name="G_HGNC:11063" fbc:label="G_HGNC__58__11063">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A5</p>
-            <p>ENSG: ENSG00000103257</p>
-            <p>HGNC ID: HGNC:11063</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6469" fbc:name="G_HGNC:6469" fbc:label="G_HGNC__58__6469">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: KYNU</p>
-            <p>ENSG: ENSG00000115919</p>
-            <p>HGNC ID: HGNC:6469</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6381" fbc:name="G_HGNC:6381" fbc:label="G_HGNC__58__6381">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: KMO</p>
-            <p>ENSG: ENSG00000117009</p>
-            <p>HGNC ID: HGNC:6381</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4796" fbc:name="G_HGNC:4796" fbc:label="G_HGNC__58__4796">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HAAO</p>
-            <p>ENSG: ENSG00000162882</p>
-            <p>HGNC ID: HGNC:4796</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19288" fbc:name="G_HGNC:19288" fbc:label="G_HGNC__58__19288">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACMSD</p>
-            <p>ENSG: ENSG00000153086</p>
-            <p>HGNC ID: HGNC:19288</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__14411" fbc:name="G_HGNC:14411" fbc:label="G_HGNC__58__14411">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC25A21</p>
-            <p>ENSG: ENSG00000183032</p>
-            <p>HGNC ID: HGNC:14411</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__18155" fbc:name="G_HGNC:18155" fbc:label="G_HGNC__58__18155">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TXNRD2</p>
-            <p>ENSG: ENSG00000184470</p>
-            <p>HGNC ID: HGNC:18155</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__12437" fbc:name="G_HGNC:12437" fbc:label="G_HGNC__58__12437">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TXNRD1</p>
-            <p>ENSG: ENSG00000198431</p>
-            <p>HGNC ID: HGNC:12437</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__93" fbc:name="G_HGNC:93" fbc:label="G_HGNC__58__93">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: ACAT1</p>
-            <p>ENSG: ENSG00000075239</p>
-            <p>HGNC ID: HGNC:93</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4455" fbc:name="G_HGNC:4455" fbc:label="G_HGNC__58__4455">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GPD1</p>
-            <p>ENSG: ENSG00000167588</p>
-            <p>HGNC ID: HGNC:4455</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__25625" fbc:name="G_HGNC:25625" fbc:label="G_HGNC__58__25625">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: OLAH</p>
-            <p>ENSG: ENSG00000152463</p>
-            <p>HGNC ID: HGNC:25625</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10547" fbc:name="G_HGNC:10547" fbc:label="G_HGNC__58__10547">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SC5D</p>
-            <p>ENSG: ENSG00000109929</p>
-            <p>HGNC ID: HGNC:10547</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3133" fbc:name="G_HGNC:3133" fbc:label="G_HGNC__58__3133">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: EBP</p>
-            <p>ENSG: ENSG00000147155</p>
-            <p>HGNC ID: HGNC:3133</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5215" fbc:name="G_HGNC:5215" fbc:label="G_HGNC__58__5215">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HSD17B7</p>
-            <p>ENSG: ENSG00000132196</p>
-            <p>HGNC ID: HGNC:5215</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__13398" fbc:name="G_HGNC:13398" fbc:label="G_HGNC__58__13398">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: NSDHL</p>
-            <p>ENSG: ENSG00000147383</p>
-            <p>HGNC ID: HGNC:13398</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__457" fbc:name="G_HGNC:457" fbc:label="G_HGNC__58__457">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AMD1</p>
-            <p>ENSG: ENSG00000123505</p>
-            <p>HGNC ID: HGNC:457</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5006" fbc:name="G_HGNC:5006" fbc:label="G_HGNC__58__5006">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HMGCR</p>
-            <p>ENSG: ENSG00000113161</p>
-            <p>HGNC ID: HGNC:5006</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7530" fbc:name="G_HGNC:7530" fbc:label="G_HGNC__58__7530">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MVK</p>
-            <p>ENSG: ENSG00000110921</p>
-            <p>HGNC ID: HGNC:7530</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__9141" fbc:name="G_HGNC:9141" fbc:label="G_HGNC__58__9141">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PMVK</p>
-            <p>ENSG: ENSG00000163344</p>
-            <p>HGNC ID: HGNC:9141</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5387" fbc:name="G_HGNC:5387" fbc:label="G_HGNC__58__5387">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDI1</p>
-            <p>ENSG: ENSG00000067064</p>
-            <p>HGNC ID: HGNC:5387</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23487" fbc:name="G_HGNC:23487" fbc:label="G_HGNC__58__23487">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDI2</p>
-            <p>ENSG: ENSG00000148377</p>
-            <p>HGNC ID: HGNC:23487</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__7529" fbc:name="G_HGNC:7529" fbc:label="G_HGNC__58__7529">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MVD</p>
-            <p>ENSG: ENSG00000167508</p>
-            <p>HGNC ID: HGNC:7529</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4249" fbc:name="G_HGNC:4249" fbc:label="G_HGNC__58__4249">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GGPS1</p>
-            <p>ENSG: ENSG00000152904</p>
-            <p>HGNC ID: HGNC:4249</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11279" fbc:name="G_HGNC:11279" fbc:label="G_HGNC__58__11279">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SQLE</p>
-            <p>ENSG: ENSG00000104549</p>
-            <p>HGNC ID: HGNC:11279</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6708" fbc:name="G_HGNC:6708" fbc:label="G_HGNC__58__6708">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LSS</p>
-            <p>ENSG: ENSG00000160285</p>
-            <p>HGNC ID: HGNC:6708</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2649" fbc:name="G_HGNC:2649" fbc:label="G_HGNC__58__2649">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: CYP51A1</p>
-            <p>ENSG: ENSG00000001630</p>
-            <p>HGNC ID: HGNC:2649</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6518" fbc:name="G_HGNC:6518" fbc:label="G_HGNC__58__6518">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: LBR</p>
-            <p>ENSG: ENSG00000143815</p>
-            <p>HGNC ID: HGNC:6518</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11863" fbc:name="G_HGNC:11863" fbc:label="G_HGNC__58__11863">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TM7SF2</p>
-            <p>ENSG: ENSG00000149809</p>
-            <p>HGNC ID: HGNC:11863</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__1334" fbc:name="G_HGNC:1334" fbc:label="G_HGNC__58__1334">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FAXDC2</p>
-            <p>ENSG: ENSG00000170271</p>
-            <p>HGNC ID: HGNC:1334</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__19340" fbc:name="G_HGNC:19340" fbc:label="G_HGNC__58__19340">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MAGEA2B</p>
-            <p>ENSG: ENSG00000183305</p>
-            <p>HGNC ID: HGNC:19340</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10545" fbc:name="G_HGNC:10545" fbc:label="G_HGNC__58__10545">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: MSMO1</p>
-            <p>ENSG: ENSG00000052802</p>
-            <p>HGNC ID: HGNC:10545</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__3629" fbc:name="G_HGNC:3629" fbc:label="G_HGNC__58__3629">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: FDFT1</p>
-            <p>ENSG: ENSG00000079459</p>
-            <p>HGNC ID: HGNC:3629</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4378" fbc:name="G_HGNC:4378" fbc:label="G_HGNC__58__4378">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GMPS</p>
-            <p>ENSG: ENSG00000163655</p>
-            <p>HGNC ID: HGNC:4378</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6052" fbc:name="G_HGNC:6052" fbc:label="G_HGNC__58__6052">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IMPDH1</p>
-            <p>ENSG: ENSG00000106348</p>
-            <p>HGNC ID: HGNC:6052</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6053" fbc:name="G_HGNC:6053" fbc:label="G_HGNC__58__6053">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IMPDH2</p>
-            <p>ENSG: ENSG00000178035</p>
-            <p>HGNC ID: HGNC:6053</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20151" fbc:name="G_HGNC:20151" fbc:label="G_HGNC__58__20151">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC17A8</p>
-            <p>ENSG: ENSG00000179520</p>
-            <p>HGNC ID: HGNC:20151</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16703" fbc:name="G_HGNC:16703" fbc:label="G_HGNC__58__16703">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC17A6</p>
-            <p>ENSG: ENSG00000091664</p>
-            <p>HGNC ID: HGNC:16703</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__16704" fbc:name="G_HGNC:16704" fbc:label="G_HGNC__58__16704">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC17A7</p>
-            <p>ENSG: ENSG00000104888</p>
-            <p>HGNC ID: HGNC:16704</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4119" fbc:name="G_HGNC:4119" fbc:label="G_HGNC__58__4119">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GALK2</p>
-            <p>ENSG: ENSG00000156958</p>
-            <p>HGNC ID: HGNC:4119</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4118" fbc:name="G_HGNC:4118" fbc:label="G_HGNC__58__4118">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GALK1</p>
-            <p>ENSG: ENSG00000108479</p>
-            <p>HGNC ID: HGNC:4118</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4135" fbc:name="G_HGNC:4135" fbc:label="G_HGNC__58__4135">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GALT</p>
-            <p>ENSG: ENSG00000213930</p>
-            <p>HGNC ID: HGNC:4135</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8905" fbc:name="G_HGNC:8905" fbc:label="G_HGNC__58__8905">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGM1</p>
-            <p>ENSG: ENSG00000079739</p>
-            <p>HGNC ID: HGNC:8905</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8906" fbc:name="G_HGNC:8906" fbc:label="G_HGNC__58__8906">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PGM2</p>
-            <p>ENSG: ENSG00000169299</p>
-            <p>HGNC ID: HGNC:8906</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4116" fbc:name="G_HGNC:4116" fbc:label="G_HGNC__58__4116">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GALE</p>
-            <p>ENSG: ENSG00000117308</p>
-            <p>HGNC ID: HGNC:4116</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11064" fbc:name="G_HGNC:11064" fbc:label="G_HGNC__58__11064">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A6</p>
-            <p>ENSG: ENSG00000103064</p>
-            <p>HGNC ID: HGNC:11064</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10942" fbc:name="G_HGNC:10942" fbc:label="G_HGNC__58__10942">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC1A4</p>
-            <p>ENSG: ENSG00000115902</p>
-            <p>HGNC ID: HGNC:10942</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11067" fbc:name="G_HGNC:11067" fbc:label="G_HGNC__58__11067">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A9</p>
-            <p>ENSG: ENSG00000021488</p>
-            <p>HGNC ID: HGNC:11067</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11065" fbc:name="G_HGNC:11065" fbc:label="G_HGNC__58__11065">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A7</p>
-            <p>ENSG: ENSG00000155465</p>
-            <p>HGNC ID: HGNC:11065</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11026" fbc:name="G_HGNC:11026" fbc:label="G_HGNC__58__11026">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC3A2</p>
-            <p>ENSG: ENSG00000168003</p>
-            <p>HGNC ID: HGNC:11026</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__23087" fbc:name="G_HGNC:23087" fbc:label="G_HGNC__58__23087">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC43A2</p>
-            <p>ENSG: ENSG00000278550</p>
-            <p>HGNC ID: HGNC:23087</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11058" fbc:name="G_HGNC:11058" fbc:label="G_HGNC__58__11058">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A10</p>
-            <p>ENSG: ENSG00000130876</p>
-            <p>HGNC ID: HGNC:11058</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10971" fbc:name="G_HGNC:10971" fbc:label="G_HGNC__58__10971">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC22A7</p>
-            <p>ENSG: ENSG00000137204</p>
-            <p>HGNC ID: HGNC:10971</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11066" fbc:name="G_HGNC:11066" fbc:label="G_HGNC__58__11066">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A8</p>
-            <p>ENSG: ENSG00000092068</p>
-            <p>HGNC ID: HGNC:11066</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11054" fbc:name="G_HGNC:11054" fbc:label="G_HGNC__58__11054">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A7</p>
-            <p>ENSG: ENSG00000011083</p>
-            <p>HGNC ID: HGNC:11054</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__30927" fbc:name="G_HGNC:30927" fbc:label="G_HGNC__58__30927">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC6A20</p>
-            <p>ENSG: ENSG00000163817</p>
-            <p>HGNC ID: HGNC:30927</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11025" fbc:name="G_HGNC:11025" fbc:label="G_HGNC__58__11025">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC3A1</p>
-            <p>ENSG: ENSG00000138079</p>
-            <p>HGNC ID: HGNC:11025</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11059" fbc:name="G_HGNC:11059" fbc:label="G_HGNC__58__11059">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC7A11</p>
-            <p>ENSG: ENSG00000151012</p>
-            <p>HGNC ID: HGNC:11059</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__8582" fbc:name="G_HGNC:8582" fbc:label="G_HGNC__58__8582">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: PAH</p>
-            <p>ENSG: ENSG00000171759</p>
-            <p>HGNC ID: HGNC:8582</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__10963" fbc:name="G_HGNC:10963" fbc:label="G_HGNC__58__10963">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: SLC22A1</p>
-            <p>ENSG: ENSG00000175003</p>
-            <p>HGNC ID: HGNC:10963</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__5028" fbc:name="G_HGNC:5028" fbc:label="G_HGNC__58__5028">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HNMT</p>
-            <p>ENSG: ENSG00000150540</p>
-            <p>HGNC ID: HGNC:5028</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__2859" fbc:name="G_HGNC:2859" fbc:label="G_HGNC__58__2859">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: DHCR24</p>
-            <p>ENSG: ENSG00000116133</p>
-            <p>HGNC ID: HGNC:2859</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4093" fbc:name="G_HGNC:4093" fbc:label="G_HGNC__58__4093">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: GAD2</p>
-            <p>ENSG: ENSG00000136750</p>
-            <p>HGNC ID: HGNC:4093</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4799" fbc:name="G_HGNC:4799" fbc:label="G_HGNC__58__4799">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HADH</p>
-            <p>ENSG: ENSG00000138796</p>
-            <p>HGNC ID: HGNC:4799</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__4800" fbc:name="G_HGNC:4800" fbc:label="G_HGNC__58__4800">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: HSD17B10</p>
-            <p>ENSG: ENSG00000072506</p>
-            <p>HGNC ID: HGNC:4800</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__20910" fbc:name="G_HGNC:20910" fbc:label="G_HGNC__58__20910">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: AFMID</p>
-            <p>ENSG: ENSG00000183077</p>
-            <p>HGNC ID: HGNC:20910</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__27269" fbc:name="G_HGNC:27269" fbc:label="G_HGNC__58__27269">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDO2</p>
-            <p>ENSG: ENSG00000188676</p>
-            <p>HGNC ID: HGNC:27269</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__6059" fbc:name="G_HGNC:6059" fbc:label="G_HGNC__58__6059">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: IDO1</p>
-            <p>ENSG: ENSG00000131203</p>
-            <p>HGNC ID: HGNC:6059</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-      <fbc:geneProduct fbc:id="G_HGNC__58__11708" fbc:name="G_HGNC:11708" fbc:label="G_HGNC__58__11708">
-        <notes>
-          <html xmlns="http://www.w3.org/1999/xhtml">
-            <p>HGNC symbol: TDO2</p>
-            <p>ENSG: ENSG00000151790</p>
-            <p>HGNC ID: HGNC:11708</p>
-          </html>
-        </notes>
-      </fbc:geneProduct>
-    </fbc:listOfGeneProducts>
-  </model>
-</sbml>