Mercurial > repos > bimib > marea
view Marea/local/HMRcoreMap.svg @ 35:7b1971251c63 draft
Uploaded
| author | bimib |
|---|---|
| date | Mon, 25 Nov 2019 05:40:30 -0500 |
| parents | 23ac9cf12788 |
| children |
line wrap: on
line source
<?xml version="1.0" encoding="UTF-8" standalone="no"?> <!-- Generator: Adobe Illustrator 22.0.1, SVG Export Plug-In . SVG Version: 6.00 Build 0) --> <svg xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:cc="http://creativecommons.org/ns#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:svg="http://www.w3.org/2000/svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd" xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape" version="1.1" x="0px" y="0px" viewBox="0 0 1904.8016 1511.2752" xml:space="preserve" id="svg2" inkscape:version="0.91 r13725" sodipodi:docname="HMRcoreMap.svg" width="1904.8015" height="1511.2753"><metadata id="metadata2021"><rdf:RDF><cc:Work rdf:about=""><dc:format>image/svg+xml</dc:format><dc:type rdf:resource="http://purl.org/dc/dcmitype/StillImage" /><dc:title /></cc:Work></rdf:RDF></metadata><defs id="defs2019"><sodipodi:namedview showguides="true" showgrid="true" pagecolor="#ffffff" inkscape:zoom="1.4702451" inkscape:window-y="-8" inkscape:window-x="-8" inkscape:window-width="1920" inkscape:window-maximized="1" inkscape:window-height="1017" inkscape:snap-page="false" inkscape:snap-grids="true" inkscape:pageshadow="2" inkscape:pageopacity="0.0" inkscape:document-units="px" inkscape:cy="338.10986" inkscape:cx="1343.7768" inkscape:current-layer="layer1" id="base" fit-margin-top="0" fit-margin-right="0" fit-margin-left="0" fit-margin-bottom="0" borderopacity="1.0" bordercolor="#666666"><inkscape:grid type="xygrid" originy="72.926308" originx="-97.409688" id="grid3434" dotted="true" /></sodipodi:namedview></defs><sodipodi:namedview pagecolor="#ffffff" bordercolor="#666666" borderopacity="1" objecttolerance="10" gridtolerance="10" guidetolerance="10" inkscape:pageopacity="0" inkscape:pageshadow="2" inkscape:window-width="1920" inkscape:window-height="1017" id="namedview2017" showgrid="false" inkscape:zoom="0.44727204" inkscape:cx="497.63252" inkscape:cy="796.80241" inkscape:window-x="-8" inkscape:window-y="-8" inkscape:window-maximized="1" inkscape:current-layer="svg2" fit-margin-top="0" fit-margin-left="0" fit-margin-right="0" fit-margin-bottom="0" /><style type="text/css" id="style4"> .st0{display:none;} .st1{display:inline;} .st2{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;} .st3{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422,11.9422;} .st4{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815,12.1815;} .st5{font-family:'Helvetica';} .st6{font-size:30px;} .st7{font-size:39.262px;} .st8{fill:none;stroke:#0000FF;stroke-width:30;} .st9{fill:none;stroke:#E41A1C;stroke-width:30;} .st10{fill:none;stroke:#BEBEBE;stroke-width:30;} .st11{stroke:#000000;stroke-width:30;} .st12{fill:none;stroke:#BEBEBE;stroke-width:30;stroke-dasharray:30,30;stroke-dashoffset:6;} .st13{fill:none;stroke:#000000;stroke-width:1.8444;} .st14{fill:none;stroke:#000000;stroke-width:2.1821;} .st15{font-family:'Calibri-Bold';} .st16{font-size:16px;} .st17{font-family:'Calibri';} .st18{font-size:10px;} .st19{fill:none;stroke:#000000;stroke-width:1.8856;} .st20{fill:none;stroke:#000000;stroke-width:1.9459;} .st21{fill:none;stroke:#000000;stroke-width:2.2892;} .st22{fill:none;stroke:#000000;stroke-width:2.5;} .st23{fill:none;stroke:#000000;stroke-width:1.9412;} .st24{fill:none;stroke:#000000;stroke-width:1.9661;} .st25{fill:none;stroke:#000000;stroke-width:1.0869;} .st26{font-size:6.0937px;} .st27{fill:none;stroke:#000000;stroke-width:2.0174;} .st28{fill:none;stroke:#000000;stroke-width:1.889;} .st29{fill:none;stroke:#000000;stroke-width:1.7769;} .st30{fill:none;stroke:#000000;stroke-width:1.8717;} .st31{fill:none;stroke:#000000;stroke-width:1.6971;} .st32{fill:none;stroke:#000000;stroke-width:2.4492;} .st33{fill:none;stroke:#000000;stroke-width:2.0366;} .st34{fill:none;stroke:#000000;stroke-width:1.5903;} .st35{fill:none;stroke:#000000;stroke-width:1.7287;} .st36{fill:none;stroke:#000000;stroke-width:1.7741;} .st37{fill:none;stroke:#000000;stroke-width:2.2309;} .st38{font-size:14px;} .st39{fill:none;stroke:#000000;stroke-width:1.7752;} .st40{font-size:9.75px;} .st41{fill:none;stroke:#000000;stroke-width:1.8816;} .st42{fill:none;stroke:#000000;stroke-width:1.8615;} .st43{fill:none;stroke:#000000;stroke-width:1.7923;} .st44{fill:none;stroke:#000000;stroke-width:1.8691;} .st45{fill:none;stroke:#000000;stroke-width:2.823;} .st46{fill:none;stroke:#000000;stroke-width:2.3556;} .st47{fill:none;stroke:#000000;stroke-width:2.0484;} .st48{fill:none;stroke:#000000;stroke-width:1.127;} .st49{fill:none;stroke:#000000;stroke-width:1.5383;} .st50{fill:none;stroke:#000000;stroke-width:1.4921;} .st51{fill:none;stroke:#000000;stroke-width:1.4117;} .st52{fill:none;stroke:#000000;stroke-width:1.3787;} .st53{fill:none;stroke:#000000;stroke-width:2.2437;} .st54{fill:none;stroke:#000000;stroke-width:1.8492;} .st55{fill:none;stroke:#000000;stroke-width:1.816;} .st56{fill:none;stroke:#000000;stroke-width:2.0159;} .st57{fill:none;stroke:#000000;stroke-width:2.0089;} .st58{fill:none;stroke:#000000;stroke-width:1.2666;} .st59{fill:none;stroke:#000000;stroke-width:1.3186;} .st60{fill:none;stroke:#000000;stroke-width:1.2211;} .st61{fill:none;stroke:#000000;stroke-width:1.1828;} .st62{fill:none;stroke:#000000;stroke-width:2.0699;} .st63{fill:none;stroke:#000000;stroke-width:2.1781;} .st64{fill:none;stroke:#000000;stroke-width:2.6751;} .st65{fill:none;stroke:#000000;stroke-width:3.1636;} .st66{fill:none;stroke:#000000;stroke-width:3.3699;} .st67{fill:none;stroke:#000000;stroke-width:2.3147;} .st68{fill:none;stroke:#000000;stroke-width:2.2203;} .st69{fill:none;stroke:#000000;stroke-width:2.2293;} .st70{fill:none;stroke:#000000;stroke-width:1.9667;} .st71{fill:none;stroke:#000000;stroke-width:2.1341;} .st72{fill:none;stroke:#000000;stroke-width:1.5819;} .st73{fill:none;stroke:#000000;stroke-width:2.0995;} .st74{fill:none;stroke:#000000;stroke-width:2.4348;} .st75{fill:none;stroke:#000000;stroke-width:2.3313;} .st76{fill:none;stroke:#000000;stroke-width:2.0948;} .st77{fill:none;stroke:#000000;stroke-width:2.2352;} .st78{fill:none;stroke:#000000;stroke-width:2.3817;} .st79{fill:none;stroke:#000000;stroke-width:2.2976;} .st80{fill:none;stroke:#000000;stroke-width:2.0951;} .st81{fill:none;stroke:#231F20;stroke-width:7;stroke-linejoin:round;stroke-miterlimit:2;} .st82{fill:none;stroke:#000000;stroke-width:1.3247;} .st83{fill:none;stroke:#000000;stroke-width:1.564;} .st84{fill:none;stroke:#000000;stroke-width:2.1156;} .st85{fill:none;stroke:#000000;stroke-width:1.3926;} .st86{fill:none;stroke:#000000;stroke-width:1.123;} .st87{font-size:9.7577px;} .st88{font-size:15.6123px;} .st89{fill:none;stroke:#000000;stroke-width:2.0926;} .st90{fill:none;stroke:#000000;stroke-width:1.7671;} .st91{fill:none;stroke:#000000;stroke-width:1.7901;} .st92{fill:none;stroke:#000000;stroke-width:1.9212;} .st93{fill:none;stroke:#000000;stroke-width:1.3319;} .st94{fill:none;stroke:#000000;stroke-width:2.1398;} .st95{fill:none;stroke:#000000;stroke-width:1.3641;} .st96{fill:none;stroke:#000000;stroke-width:2.216;} .st97{fill:none;stroke:#000000;stroke-width:2.341;} .st98{fill:none;stroke:#000000;stroke-width:1.2412;} .st99{fill:none;stroke:#000000;stroke-width:1.7827;} .st100{fill:none;stroke:#000000;stroke-width:1.8658;} .st101{fill:none;stroke:#000000;stroke-width:2.4932;} .st102{fill:none;stroke:#000000;stroke-width:2.489;} .st103{fill:none;stroke:#000000;stroke-width:2.5188;} .st104{fill:none;stroke:#000000;stroke-width:2.4962;} .st105{fill:none;stroke:#000000;stroke-width:1.6791;} .st106{fill:none;stroke:#000000;stroke-width:1.8121;} .st107{fill:none;stroke:#000000;stroke-width:1.5802;} .st108{fill:none;stroke:#000000;stroke-width:1.5346;} .st109{fill:none;stroke:#000000;stroke-width:1.8293;} .st110{fill:none;stroke:#000000;stroke-width:1.6126;} .st111{fill:none;stroke:#000000;stroke-width:2.5434;} .st112{fill:none;stroke:#000000;stroke-width:1.7519;} .st113{fill:none;stroke:#000000;stroke-width:1.5283;} .st114{fill:none;stroke:#000000;stroke-width:1.8016;} .st115{fill:none;stroke:#000000;stroke-width:3.1376;} .st116{fill:none;stroke:#000000;stroke-width:1.8065;} .st117{fill:none;stroke:#000000;stroke-width:2.1653;} .st118{fill:none;stroke:#000000;stroke-width:1.5857;} .st119{fill:none;stroke:#000000;stroke-width:2.1349;} .st120{fill:none;stroke:#000000;stroke-width:2.3204;} .st121{fill:none;stroke:#000000;stroke-width:1.6814;} .st122{fill:none;stroke:#000000;stroke-width:2.9048;} .st123{fill:none;stroke:#000000;stroke-width:2.2582;} .st124{fill:none;stroke:#000000;stroke-width:1.9206;} .st125{fill:none;stroke:#000000;stroke-width:2.0975;} .st126{fill:none;stroke:#000000;stroke-width:1.1759;} .st127{fill:none;stroke:#000000;stroke-width:1.1348;} .st128{fill:none;stroke:#000000;stroke-width:2.0031;} .st129{fill:none;stroke:#000000;stroke-width:1.966;} .st130{fill:none;stroke:#000000;stroke-width:1.822;} .st131{fill:none;stroke:#000000;stroke-width:2.3785;} .st132{fill:none;stroke:#000000;stroke-width:1.5336;} .st133{fill:none;stroke:#000000;stroke-width:1.4989;} .st134{fill:none;stroke:#000000;stroke-width:1.8163;} .st135{fill:none;stroke:#000000;stroke-width:2.0955;} .st136{fill:none;stroke:#000000;stroke-width:2.1429;} .st137{fill:none;stroke:#000000;stroke-width:2.1034;} .st138{fill:none;stroke:#000000;stroke-width:2.0686;} .st139{fill:none;stroke:#000000;stroke-width:1.1187;} .st140{fill:none;stroke:#000000;stroke-width:2.3278;} .st141{fill:none;stroke:#000000;stroke-width:2.1814;} .st142{fill:none;stroke:#000000;stroke-width:2.0648;} .st143{fill:none;stroke:#000000;stroke-width:2.5236;} .st144{fill:none;stroke:#000000;stroke-width:2.5697;} .st145{fill:#786721;stroke:#000000;stroke-width:2.5;} .st146{fill:none;stroke:#000000;stroke-width:1.4509;} .st147{fill:none;stroke:#000000;stroke-width:1.7529;} .st148{fill:none;stroke:#000000;stroke-width:1.9252;} .st149{fill:none;stroke:#000000;stroke-width:1.8983;} .st150{fill:none;stroke:#000000;stroke-width:1.7735;} .st151{fill:none;stroke:#000000;stroke-width:1.5537;} .st152{fill:none;stroke:#000000;stroke-width:1.7117;} .st153{fill:none;stroke:#000000;stroke-width:1.7429;} .st154{fill:none;stroke:#000000;stroke-width:1.639;} .st155{fill:none;stroke:#000000;stroke-width:2.4155;} .st156{fill:none;stroke:#000000;stroke-width:1.9672;} .st157{fill:none;stroke:#000000;stroke-width:2.2231;} .st158{fill:none;stroke:#000000;stroke-width:1.8337;} .st159{fill:none;stroke:#000000;stroke-width:1.8531;} .st160{fill:none;stroke:#000000;stroke-width:2.2256;} .st161{fill:none;stroke:#000000;stroke-width:2.0666;} .st162{fill:none;stroke:#000000;stroke-width:1.7335;} .st163{fill:none;stroke:#000000;stroke-width:1.6847;} .st164{fill:none;stroke:#000000;stroke-width:2.4884;} .st165{fill:none;stroke:#000000;stroke-width:2.3113;} .st166{fill:none;stroke:#000000;stroke-width:2.1555;} .st167{fill:none;stroke:#000000;stroke-width:1.9909;} .st168{fill:none;stroke:#000000;stroke-width:9.2205;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:2;} .st169{fill:none;stroke:#000000;stroke-width:2.5668;} .st170{fill:none;stroke:#000000;stroke-width:1.9328;} .st171{fill:none;stroke:#000000;stroke-width:3.1971;} .st172{fill:none;stroke:#000000;stroke-width:3.1373;} .st173{font-size:6.5px;} </style><g id="Layer_2" transform="translate(-20.6,18.418554)"><g id="rect3188_1_" class="st0" style="display:none"><g class="st1" id="g8" style="display:inline"><polyline class="st2" points="269.1,669.8 269.1,663.8 275.1,663.8 " id="polyline10" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line class="st3" x1="287" y1="663.79999" x2="1475.2" y2="663.79999" id="line12" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422, 11.9422" /><polyline class="st2" points="1481.2,663.8 1487.2,663.8 1487.2,669.8 " id="polyline14" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line class="st4" x1="1487.2" y1="682" x2="1487.2" y2="1138.8" id="line16" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815, 12.1815" /><polyline class="st2" points="1487.2,1144.9 1487.2,1150.9 1481.2,1150.9 " id="polyline18" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line class="st3" x1="1469.3" y1="1150.9" x2="281" y2="1150.9" id="line20" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422, 11.9422" /><polyline class="st2" points="275.1,1150.9 269.1,1150.9 269.1,1144.9 " id="polyline22" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line class="st4" x1="269.10001" y1="1132.7" x2="269.10001" y2="675.90002" id="line24" style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815, 12.1815" /></g></g></g><g id="flowRoot3336" transform="translate(-20.6,18.418554)" /><g id="flowRoot16808" transform="translate(-20.6,18.418554)" /><g id="flowRoot2749" transform="translate(-20.6,18.418554)" /><g id="flowRoot3621" transform="translate(-20.6,18.418554)" /><g id="flowRoot1974" transform="translate(-20.6,18.418554)" /><text style="font-size:30px;font-family:Helvetica" id="text35" class="st5 st6" x="129.77209" y="1429.6542">= Up regulated</text> <text style="font-size:30px;font-family:Helvetica" id="text37" class="st5 st6" x="129.77209" y="1504.6542">= Down regulated</text> <text style="font-size:39.26200104px;font-family:Helvetica" id="text39" class="st5 st7" x="-1.9770008" y="1365.1874">Legend</text> <path style="fill:none;stroke:#0000ff;stroke-width:30" d="m 0,1495.6186 112,0" class="st8" inkscape:connector-curvature="0" id="path6613-3" /><path style="fill:none;stroke:#e41a1c;stroke-width:30" d="m 0,1420.7186 112,0" class="st9" inkscape:connector-curvature="0" id="path6613-8-6" /><path style="fill:none;stroke:#bebebe;stroke-width:30" d="m 503.8,1492.0186 112,0" class="st10" inkscape:connector-curvature="0" id="path6613-8-1-0" /><path style="stroke:#000000;stroke-width:30" d="m 1140.7,1415.1186 112,0" class="st11" inkscape:connector-curvature="0" id="path6613-8-4-9" /><path style="fill:none;stroke:#bebebe;stroke-width:30;stroke-dasharray:30, 30;stroke-dashoffset:6" d="m 503.8,1417.3186 112,0" class="st12" inkscape:connector-curvature="0" id="path6613-8-2-6" /><text style="font-size:30px;font-family:Helvetica" id="text46" class="st5 st6" x="1270.1295" y="1423.1249">= Not classified</text> <text style="font-size:30px;font-family:Helvetica" id="text48" class="st5 st6" x="631.3902" y="1426.3895">= Not significant</text> <text style="font-size:30px;font-family:Helvetica" id="text50" class="st5 st6" x="631.3902" y="1501.3895">= Fold change under threshold</text> <text style="font-size:30px;font-family:Helvetica" id="text52" class="st5 st6" x="1139.6979" y="1499.9501">Thickness is proportional to fold change</text> <path style="fill:none;stroke:#000000;stroke-width:1.84440005" d="m 834.5,332.71855 26.9,-0.1 m -18,-9 c -2.8,5.8 3.1,9.6 3.1,9.6 m 3.1,-0.5 c 5.1,-0.7 4.9,-9.1 4.9,-9.1" class="st13" inkscape:label="CMPK1_DTYMK" inkscape:connector-curvature="0" id="R_CMPK1_DTYMK" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 464.9,461.41855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="backward PGM" inkscape:connector-curvature="0" id="B_PGAM2_PGAM1_BPGM_PGAM4_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text56" class="st15 st16" x="449.63071" y="207.37375">F6P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text58" class="st15 st16" x="443.9202" y="262.58224">F16BP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text60" class="st15 st16" x="446.7605" y="320.19556">GA3P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text62" class="st15 st16" x="435.38208" y="383.34305">1,3BPGA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text64" class="st15 st16" x="453.15561" y="449.14966">3PG</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text66" class="st15 st16" x="449.81769" y="507.42996">2PG</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text68" class="st15 st16" x="453.76788" y="562.48846">PEP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text70" class="st15 st16" x="456.6004" y="614.97485">Pyr</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text72" class="st15 st16" x="349.18579" y="614.4632">Lact</text> <text style="font-size:10px;font-family:Calibri" id="text74" class="st17 st18" x="483.3494" y="222.37965">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text76" class="st17 st18" x="484.75418" y="235.29225">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text78" class="st17 st18" x="478.8587" y="337.66135">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text80" class="st17 st18" x="497.25217" y="337.66135">+</text> <text style="font-size:10px;font-family:Calibri" id="text82" class="st17 st18" x="502.2327" y="337.66135">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text84" class="st17 st18" x="481.2063" y="350.90945">NADH+H</text> <text style="font-size:10px;font-family:Calibri" id="text86" class="st17 st18" x="481.4881" y="401.51096">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text88" class="st17 st18" x="482.81668" y="413.79224">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text90" class="st17 st18" x="481.35968" y="575.7132">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text92" class="st17 st18" x="485.36938" y="586.74536">ATP</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 460,182.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st14" inkscape:label="forward GPI " inkscape:connector-curvature="0" id="F_GPI" /><path style="fill:none;stroke:#000000;stroke-width:1.88559997" d="m 462.1,159.61855 c 0,23.8 0,23.8 0,23.8" class="st19" inkscape:label="GPI " inkscape:connector-curvature="0" id="R_GPI" /><path style="fill:none;stroke:#000000;stroke-width:1.94589996" d="m 467.2,458.91855 c 0,25.4 0,25.4 0,25.4" class="st20" inkscape:label="phosphoglycerate mutase" inkscape:connector-curvature="0" id="R_PGAM2_PGAM1_BPGM_PGAM4_1" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 465.1,482.61855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st14" inkscape:label="forward PGM" inkscape:connector-curvature="0" id="F_PGAM2_PGAM1_BPGM_PGAM4_1" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 464.9,516.91855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="backward enolase" inkscape:connector-curvature="0" id="B_ENO1_ENO3_ENO2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text99" class="st15 st16" x="492.44656" y="284.29803">DHAP</text> <path style="fill:none;stroke:#000000;stroke-width:2.28920007" d="m 462.7,265.81855 c 0,31.9 0,31.9 0,31.9 m 0.6,-17.7 20.2,0" class="st21" inkscape:connector-curvature="0" id="R_ALDOC_ALDOB_ALDOA_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 482.4,278.01855 c 6.1,2.2 6.1,2.2 6.1,2.2 l -6.1,2.2 1.5,-2.2 -1.5,-2.2 z m -21.6,17.9 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st22" inkscape:connector-curvature="0" id="F_ALDOC_ALDOB_ALDOA_2" /><path style="fill:none;stroke:#000000;stroke-width:1.94120002" d="m 503.2,293.81855 2.4,-4 0.8,-1.3 -4.9,2.1 1.9,0.6 -0.2,2.6 z" class="st23" sodipodi:nodetypes="cccccc" inkscape:label="backward TPI1_TPI1P2 " inkscape:connector-curvature="0" id="B_TPI1_TPI1P2" /><path style="fill:none;stroke:#000000;stroke-width:1.96609998" d="m 488.7,300.71855 c -3.2,5.4 -3.2,5.4 -3.2,5.4 l 5,-2.3 -1.9,-0.6 0.1,-2.5 z" class="st24" inkscape:label="forwardTPI1_TPI1P2 " inkscape:connector-curvature="0" id="F_TPI1_TPI1P2" /><path style="fill:none;stroke:#000000;stroke-width:1.0869" d="m 502.6,291.71855 -14.9,13" class="st25" inkscape:label="TPI1_TPI1P2 " inkscape:connector-curvature="0" id="R_TPI1_TPI1P2" /><text style="font-size:10px;font-family:Calibri" id="text106" class="st17 st18" x="485.7688" y="533.16919">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text108" class="st17 st26" x="491.9993" y="535.16919">2</text> <text style="font-size:10px;font-family:Calibri" id="text110" class="st17 st18" x="495.08768" y="533.16919">O</text> <text style="font-size:10px;font-family:Calibri" id="text112" class="st17 st18" x="391.7298" y="593.52759">NAD</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text114" class="st15 st16" x="532.302" y="158.84834">6Pgl</text> <text style="font-size:10px;font-family:Calibri" id="text116" class="st17 st18" x="471.15601" y="174.58125">NADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text118" class="st15 st16" x="598.32654" y="159.01485">6PDG</text> <text style="font-size:10px;font-family:Calibri" id="text120" class="st17 st18" x="627.64771" y="176.58224">NADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text122" class="st15 st16" x="694.76404" y="159.07295">Ru5P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text124" class="st15 st16" x="777.18494" y="174.95485">R5P</text> <text style="font-size:10px;font-family:Calibri" id="text126" class="st17 st18" x="754.10773" y="199.29225">AMP</text> <text style="font-size:10px;font-family:Calibri" id="text128" class="st17 st18" x="760.08435" y="185.74825">ATP</text> <path style="fill:none;stroke:#000000;stroke-width:2.01740003" d="m 588.2,152.11855 c 7.3,2.2 7.3,2.2 7.3,2.2 l -7.3,2.2 1.8,-2.2 -1.8,-2.2 z" class="st27" inkscape:label="forward H6PD_PGLS " inkscape:connector-curvature="0" id="F_H6PD_PGLS" /><text style="font-size:10px;font-family:Calibri" id="text131" class="st17 st18" x="564.25323" y="173.96214">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text133" class="st17 st26" x="570.4837" y="175.96214">2</text> <text style="font-size:10px;font-family:Calibri" id="text135" class="st17 st18" x="573.57251" y="173.96214">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text137" class="st15 st16" x="774.87531" y="143.11105">Xil5P</text> <path style="fill:none;stroke:#000000;stroke-width:1.88900006" d="m 814.5,167.11855 c -5.3,2.4 -5.3,2.4 -5.3,2.4 l 2.8,-4.7 0.2,2 2.3,0.3 z m -1.4,-20.6 c -2.5,-4.8 -2.5,-4.8 -2.5,-4.8 l 5.1,2.6 -2.3,0.2 -0.3,2 z" class="st28" inkscape:label="forward TKTL1_TKTL2_TKT_2" inkscape:connector-curvature="0" id="F_TKTL1_TKTL2_TKT_2" /><path style="fill:none;stroke:#000000;stroke-width:1.88900006" d="m 834,143.41855 c 5.2,-2.5 5.2,-2.5 5.2,-2.5 l -2.6,4.7 -0.3,-2 -2.3,-0.2 z m 3.8,21.6 c 2.6,4.8 2.6,4.8 2.6,4.8 l -5.2,-2.6 2.3,-0.2 0.3,-2 z" class="st28" inkscape:label="backward TKTL1_TKTL2_TKT_2 " inkscape:connector-curvature="0" id="B_TKTL1_TKTL2_TKT_2" /><path style="fill:none;stroke:#000000;stroke-width:1.77690005" d="m 813,144.01855 23.9,22.6 0,0 m -24.8,0.5 23.9,-22.6" class="st29" inkscape:label="TKTL1_TKTL2_TKT_2 " inkscape:connector-curvature="0" id="R_TKTL1_TKTL2_TKT_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text142" class="st15 st16" x="842.75421" y="140.81226">Sed7P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text144" class="st15 st16" x="844.42902" y="174.28685">GA3P</text> <path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 890,164.31855 c -5.3,2.3 -5.3,2.3 -5.3,2.3 l 2.8,-4.5 0.2,2 2.3,0.2 z m -1.4,-20.1 c -2.5,-4.7 -2.5,-4.7 -2.5,-4.7 l 5.1,2.6 -2.3,0.1 -0.3,2 z" class="st30" inkscape:label="backward TALDO1 " inkscape:connector-curvature="0" id="B_TALDO1" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 912.3,141.61855 c 5.2,-2.4 5.2,-2.4 5.2,-2.4 l -2.7,4.6 -0.3,-2 -2.2,-0.2 z m 3.9,21.1 c 2.6,4.6 2.6,4.6 2.6,4.6 l -5.2,-2.5 2.3,-0.2 0.3,-1.9 z" class="st30" inkscape:label="forward TALDO1 " inkscape:connector-curvature="0" id="F_TALDO1" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 888.1,141.41855 26.3,22.8 0,0 m -27.2,0.6 26.3,-22.8" class="st30" inkscape:label="TALDO1 " inkscape:connector-curvature="0" id="R_TALDO1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text149" class="st15 st16" x="922.31085" y="174.11154">Ery4P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text151" class="st15 st16" x="921.73865" y="140.67255">F6P</text> <path style="fill:none;stroke:#000000;stroke-width:1.69710004" d="m 967.5,191.21855 c -5.2,1.9 -5.2,1.9 -5.2,1.9 l 2.7,-3.8 0.2,1.7 2.3,0.2 z m -1.3,-16.9 c -2.4,-3.9 -2.4,-3.9 -2.4,-3.9 l 5,2.2 -2.2,0.1 -0.4,1.6 z" class="st31" inkscape:label="forward TKTL1_TKTL2_TKT_1 " inkscape:connector-curvature="0" id="F_TKTL1_TKTL2_TKT_1" /><path style="fill:none;stroke:#000000;stroke-width:1.69710004" d="m 989.2,172.21855 c 5.1,-2 5.1,-2 5.1,-2 l -2.6,3.9 -0.3,-1.7 -2.2,-0.2 z m 3.8,17.8 c 2.5,3.9 2.5,3.9 2.5,3.9 l -5.1,-2.1 2.2,-0.2 0.4,-1.6 z" class="st31" inkscape:label="backward TKTL1_TKTL2_TKT_1 " inkscape:connector-curvature="0" id="B_TKTL1_TKTL2_TKT_1" /><path style="fill:none;stroke:#000000;stroke-width:1.69710004" d="m 965.6,172.01855 25.6,19.2 0,0 m -26.5,0.5 25.6,-19.2" class="st31" inkscape:label="TKTL1_TKTL2_TKT_1 " inkscape:connector-curvature="0" id="R_TKTL1_TKTL2_TKT_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text156" class="st15 st16" x="997.87823" y="172.36835">GA3P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text158" class="st15 st16" x="998.20343" y="200.00905">F6P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text160" class="st15 st16" x="924.83331" y="199.35765">Xil5P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text162" class="st15 st16" x="899.55011" y="119.60376">Sed1,7BP</text> <text style="font-size:10px;font-family:Calibri" id="text164" class="st17 st18" x="862.2395" y="101.52756">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text166" class="st17 st18" x="878.388" y="101.37626">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 974.2,113.01855 c -7.1,2.6 -7.1,2.6 -7.1,2.6 l 7.3,1.8 -2,-2 1.8,-2.4 z" class="st32" inkscape:label="forward ALDOC_ALDOB_ALDOA_1 " inkscape:connector-curvature="0" id="F_ALDOC_ALDOB_ALDOA_1" /><path style="fill:none;stroke:#000000;stroke-width:1.84440005" d="m 988.6,115.41855 0,13.6 m -16.1,-13.5 32.6,0" class="st13" inkscape:connector-curvature="0" id="R_ALDOC_ALDOB_ALDOA_1" /><path style="fill:none;stroke:#000000;stroke-width:2.03660011" d="m 990.5,127.81855 c -1.7,5.4 -1.7,5.4 -1.7,5.4 l -2.2,-5.2 2,1.3 1.9,-1.5 z m 13.7,-14.3 c 6.9,2.2 6.9,2.2 6.9,2.2 l -6.9,2.2 1.7,-2.2 -1.7,-2.2 z" class="st33" inkscape:label="B ALDOC_ALDOB_ALDOA_1" inkscape:connector-curvature="0" id="B_ALDOC_ALDOB_ALDOA_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text171" class="st15 st16" x="1014.1517" y="119.70486">Ery4P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text173" class="st15 st16" x="968.1048" y="145.78055">DHAP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text175" class="st15 st16" x="771.2854" y="226.97975">PRPP</text> <text style="font-size:10px;font-family:Calibri" id="text177" class="st17 st18" x="826.94464" y="243.12035">Gly</text> <text style="font-size:10px;font-family:Calibri" id="text179" class="st17 st18" x="913.92413" y="243.37524">2 10-forTHF</text> <text style="font-size:10px;font-family:Calibri" id="text181" class="st17 st18" x="857.57452" y="209.29074">2 THF</text> <text style="font-size:10px;font-family:Calibri" id="text183" class="st17 st18" x="884.82159" y="209.54565">PPi</text> <text style="font-size:10px;font-family:Calibri" id="text185" class="st17 st18" x="901.06671" y="208.81564">4 ADP</text> <text style="font-size:10px;font-family:Calibri" id="text187" class="st17 st18" x="836.94171" y="209.48065">Fum</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text189" class="st15 st16" x="1001.889" y="227.94115">IMP</text> <text style="font-size:10px;font-family:Calibri" id="text191" class="st17 st18" x="802.77081" y="243.09105">2 Gln</text> <text style="font-size:10px;font-family:Calibri" id="text193" class="st17 st18" x="812.37921" y="209.35135">2 Glu</text> <text style="font-size:10px;font-family:Calibri" id="text195" class="st17 st18" x="890.34705" y="243.16335">4 ATP</text> <text style="font-size:10px;font-family:Calibri" id="text197" class="st17 st18" x="868.02661" y="242.86446">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text199" class="st17 st26" x="874.25714" y="244.86446">2</text> <text style="font-size:10px;font-family:Calibri" id="text201" class="st17 st18" x="877.34601" y="242.86446">O</text> <text style="font-size:10px;font-family:Calibri" id="text203" class="st17 st18" x="964.69855" y="243.09105">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text205" class="st17 st26" x="976.56384" y="245.09105">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text207" class="st15 st16" x="1268.7963" y="274.35965">GDP</text> <text style="font-size:10px;font-family:Calibri" id="text209" class="st17 st18" x="1227.5297" y="295.81955">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text211" class="st17 st18" x="1245.308" y="295.39575">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text213" class="st17 st18" x="588.70343" y="538.1087">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text215" class="st17 st18" x="593.98761" y="501.60864">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text217" class="st17 st18" x="617.54913" y="538.3645">CoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text219" class="st15 st16" x="663.85974" y="522.77277">AcCoA</text> <text style="font-size:10px;font-family:Calibri" id="text221" class="st17 st18" x="631.93585" y="501.30786">OAA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text223" class="st15 st16" x="1047.556" y="522.03638">ippPP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text225" class="st15 st16" x="1123.9662" y="522.45044">fPP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text227" class="st15 st16" x="1293.7357" y="521.42017">Chol</text> <text style="font-size:10px;font-family:Calibri" id="text229" class="st17 st18" x="715.52472" y="482.08426">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text231" class="st17 st18" x="735.80505" y="481.85086">HCO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text233" class="st17 st26" x="753.9007" y="483.85086">3</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text235" class="st17 st26" x="756.98865" y="476.35086">-</text> <text style="font-size:10px;font-family:Calibri" id="text237" class="st17 st18" x="763.59314" y="481.23465">H</text> <text style="font-size:10px;font-family:Calibri" id="text239" class="st17 st18" x="727.01691" y="449.72195">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text241" class="st17 st18" x="766.38605" y="449.12424">Pi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text243" class="st15 st16" x="790.05304" y="468.83524">MalCoA</text> <text style="font-size:10px;font-family:Calibri" id="text245" class="st17 st18" x="882.31775" y="413.45636">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text247" class="st17 st26" x="894.18292" y="415.45636">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text249" class="st15 st16" x="914.74835" y="432.96216">AcAcACP</text> <text style="font-size:10px;font-family:Calibri" id="text251" class="st17 st18" x="999.9397" y="447.29025">14NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text253" class="st17 st18" x="1008.5541" y="412.44064">14NADP</text> <text style="font-size:10px;font-family:Calibri" id="text255" class="st17 st18" x="1071.347" y="412.67795">6 H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text257" class="st17 st26" x="1084.9066" y="414.67795">2</text> <text style="font-size:10px;font-family:Calibri" id="text259" class="st17 st18" x="1087.9945" y="412.67795">O</text> <text style="font-size:10px;font-family:Calibri" id="text261" class="st17 st18" x="1045.3734" y="412.36255">6 CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text263" class="st17 st26" x="1064.5677" y="414.36255">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text265" class="st15 st16" x="1105.4926" y="433.46994">Palm</text> <text style="font-size:10px;font-family:Calibri" id="text267" class="st17 st18" x="949.78149" y="447.81464">6 MalACP</text> <text style="font-size:10px;font-family:Calibri" id="text269" class="st17 st18" x="982.41632" y="413.04025">7 ACP</text> <text style="font-size:10px;font-family:Calibri" id="text271" class="st17 st18" x="857.53351" y="449.55005">CoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text273" class="st15 st16" x="887.2757" y="468.92606">MalACP</text> <text style="font-size:10px;font-family:Calibri" id="text275" class="st17 st18" x="848.5813" y="482.83524">ACP</text> <text style="font-size:10px;font-family:Calibri" id="text277" class="st17 st18" x="756.85382" y="411.64575">CoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text279" class="st15 st16" x="791.37335" y="434.89474">AcACP</text> <text style="font-size:10px;font-family:Calibri" id="text281" class="st17 st18" x="747.01202" y="447.85574">ACP</text> <path style="fill:none;stroke:#000000;stroke-width:1.59029996" d="m 761,430.21855 c -5.4,1.2 -4.9,10.4 -4.9,10.4 m 4.5,-10.5 c 5.3,-1 4,-9.8 4,-9.8 m -64.6,89 0.4,-79.2 79.6,0" class="st34" inkscape:connector-curvature="0" id="R_FASN_1" /><path style="fill:none;stroke:#000000;stroke-width:1.72870004" d="m 855.7,430.31855 c 6.2,-0.4 7.2,-8.3 7.2,-8.3 m 28,33.5 -10,-25.7 m -45.2,0.4 68.9,-0.3 m -20.5,0.2 c 6.1,-0.6 6.4,-8.5 6.4,-8.5" class="st35" inkscape:connector-curvature="0" id="R_AcAcACPSynthesis" /><text style="font-size:10px;font-family:Calibri" id="text285" class="st17 st18" x="855.91821" y="414.73166">ACP</text> <path style="fill:none;stroke:#000000;stroke-width:1.77409995" d="m 729.6,464.51855 c -6,1.1 -5.5,9.1 -5.5,9.1 m 5.8,-9.3 c 5.9,-0.9 4.4,-8.8 4.4,-8.8 m 30.6,8.8 c 5.9,-0.9 4.4,-8.8 4.4,-8.8 m -59.2,8.5 25.7,0.6 44.2,-0.3 m -28,0.2 c -6,1.1 -5.5,9.1 -5.5,9.1 m 25.5,-9.1 c -6,1.1 -5.5,9.1 -5.5,9.1 m -56.2,37.3 0,-47.7" class="st36" inkscape:label="ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" inkscape:connector-curvature="0" id="R_ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" /><path style="fill:none;stroke:#000000;stroke-width:2.23090005" d="m 1428,1116.5186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 57.5,-14.1 c 1.8,-5.9 1.8,-5.9 1.8,-5.9 l 2.5,5.6 -2.3,-1.3 -2,1.6 z" class="st37" inkscape:connector-curvature="0" id="F_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1499.2,1027.2186 -73.8,0 0,0 m 21.8,0 c -5.9,-1.6 -4.4,-14.8 -4.4,-14.8 m 43.4,14.6 c 4.7,-3.6 3.8,-14.7 1.1,-14.6" class="st32" inkscape:connector-curvature="0" id="R_SLC25A3" /><text style="font-size:16px;font-family:Calibri-Bold" id="text290" class="st15 st16" x="1480.8578" y="1008.175">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text292" class="st15 st16" x="1501.9437" y="1029.9797">Pi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text294" class="st15 st16" x="1438.8285" y="1005.4563">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text296" class="st15 st16" x="1401.4027" y="1030.7034">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.23090005" d="m 1425.9,1028.9186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 14.4,-15.2 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z" class="st37" inkscape:connector-curvature="0" id="F_SLC25A3" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1502.9,1072.8186 c -24.6,0 -49.2,0 -73.8,0 m 21.8,0 c -3.5,-1 -4.2,-5.1 -4.5,-8.3 -0.2,-2 -0.1,-3.9 0.1,-5.9 m 43,14 c 0.4,-4.6 2.5,-9 2.7,-13.7 0,-0.4 -0.1,-1.1 -0.7,-1.1" class="st32" inkscape:connector-curvature="0" id="R_SLC25A5_SLC25A4_SLC25A6" /><text style="font-size:16px;font-family:Calibri-Bold" id="text300" class="st15 st16" x="1479.5199" y="1049.1731">ATP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text302" class="st15 st16" x="1511.3929" y="1077.179">ADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text304" class="st15 st16" x="1432.8539" y="1049.8508">ATP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text306" class="st15 st16" x="1391.6039" y="1077.1125">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:2.23090005" d="m 1429.5,1074.5186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 61,-14.2 c 2.1,-5.8 2.1,-5.8 2.1,-5.8 l 2.2,5.7 -2.2,-1.4 -2.1,1.5 z" class="st37" inkscape:label="#F_SLC25A5_SLC25A4_SLC25A6" inkscape:connector-curvature="0" id="F_SLC25A5_SLC25A4_SLC25A6" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1501.4,1114.8186 -73.8,0 0,0 m 21.8,0 c -5.9,-1.4 -4.4,-13.5 -4.4,-13.5 m 41.7,-1 c 3.2,6.1 -5.5,14.6 -5.5,14.6" class="st32" inkscape:connector-curvature="0" id="R_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><text style="font-size:14px;font-family:Calibri-Bold" id="text310" class="st15 st38" x="1473.5541" y="1092.8215">GTP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text312" class="st15 st16" x="1509.8929" y="1117.5793">GDP</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text314" class="st15 st38" x="1428.8754" y="1092.8958">GTP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text316" class="st15 st16" x="1390.0355" y="1119.3235">GDP</text> <path style="fill:none;stroke:#000000;stroke-width:2.23090005" d="m 1500.2,1112.5186 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z m -57.8,-10.4 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z" class="st37" inkscape:connector-curvature="0" id="B_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1442.3,832.21855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" class="st32" inkscape:label="forward AQP8 " inkscape:connector-curvature="0" id="F_AQP8" /><path style="fill:none;stroke:#000000;stroke-width:1.77520001" d="m 1493,830.41855 -50.4,0 0,0" class="st39" inkscape:label="AQP8 " inkscape:connector-curvature="0" id="R_AQP8" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1489,828.11855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" class="st32" inkscape:transform-center-y="2.6134784" inkscape:transform-center-x="-0.38596577" inkscape:label="backward AQP8 " inkscape:connector-curvature="0" id="B_AQP8" /><text style="font-size:16px;font-family:Calibri-Bold" id="text322" class="st15 st16" x="1501.9828" y="834.84888">H</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text324" class="st15 st40" x="1512.0765" y="838.04907">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text326" class="st15 st16" x="1517.0179" y="834.84888">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text328" class="st15 st16" x="1405.2406" y="834.85181">H</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text330" class="st15 st40" x="1415.3344" y="838.052">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text332" class="st15 st16" x="1420.2758" y="834.85181">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text334" class="st15 st16" x="1501.2924" y="920.34888">O</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text336" class="st15 st40" x="1512.1127" y="923.54907">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text338" class="st15 st16" x="1414.5111" y="921.31366">O</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text340" class="st15 st40" x="1425.3314" y="924.51385">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text342" class="st15 st16" x="1500.6859" y="857.42798">CO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text344" class="st15 st40" x="1519.8578" y="860.6272">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text346" class="st15 st16" x="1405.0785" y="858.29315">CO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text348" class="st15 st40" x="1424.2504" y="861.49341">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text350" class="st15 st16" x="1500.932" y="879.84888">CoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text352" class="st15 st16" x="1400.6957" y="879.69458">CoA</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1441.9,917.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" class="st32" inkscape:label="TransportOxygen F" inkscape:connector-curvature="0" id="F_TransportOxygen" /><path style="fill:none;stroke:#000000;stroke-width:1.88160002" d="m 1497.8,915.91855 -56.7,0 0,0" class="st41" inkscape:label="TransportOxygen" inkscape:connector-curvature="0" id="R_TransportOxygen" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1440.8,854.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" class="st32" inkscape:label="forward Transport_CO2 " inkscape:connector-curvature="0" id="F_Transport_CO2" /><path style="fill:none;stroke:#000000;stroke-width:1.86150002" d="m 1493.5,852.91855 -55.5,0 0,0" class="st42" inkscape:label="Transport_CO2 " inkscape:connector-curvature="0" id="R_Transport_CO2" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1489,850.31855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" class="st32" inkscape:transform-center-y="2.6134784" inkscape:transform-center-x="-0.38596577" inkscape:label="backward Transport_CO2 " inkscape:connector-curvature="0" id="B_Transport_CO2" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1440.8,877.21855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" class="st32" inkscape:label="backward SLC25A16 " inkscape:connector-curvature="0" id="B_SLC25A16" /><path style="fill:none;stroke:#000000;stroke-width:1.79229999" d="m 1492.5,875.11855 -51.4,0 0,0" class="st43" inkscape:label="SLC25A16 " inkscape:connector-curvature="0" id="R_SLC25A16" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1490.5,872.71855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" class="st32" inkscape:transform-center-y="2.6134784" inkscape:transform-center-x="-0.38596577" inkscape:label="forward SLC25A16 " inkscape:connector-curvature="0" id="F_SLC25A16" /><text style="font-size:16px;font-family:Calibri-Bold" id="text362" class="st15 st16" x="1501.2006" y="899.49829">NH</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text364" class="st15 st40" x="1521.8334" y="902.69849">3</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text366" class="st15 st16" x="1402.0922" y="899.6507">NH</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text368" class="st15 st40" x="1422.725" y="902.85089">3</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1439.3,896.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" class="st32" inkscape:label="forward HIBCH " inkscape:connector-curvature="0" id="F_HIBCH" /><path style="fill:none;stroke:#000000;stroke-width:1.86909997" d="m 1494.1,894.91855 -55.9,0 0,0" class="st44" inkscape:label="HIBCH " inkscape:connector-curvature="0" id="R_HIBCH" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1490.8,892.61855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" class="st32" inkscape:transform-center-y="2.6134784" inkscape:transform-center-x="-0.38596577" inkscape:label="backward HIBCH " inkscape:connector-curvature="0" id="B_HIBCH" /><text style="font-size:16px;font-family:Calibri-Bold" id="text373" class="st15 st16" x="183.5808" y="877.27655">AKG</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text375" class="st15 st16" x="284.44901" y="878.07635">AKG</text> <path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 275.8,872.81855 -60.2,-0.3 m 44.6,0.3 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -26.7,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7" class="st45" inkscape:connector-curvature="0" id="R_SLC25A10_3" /><text style="font-size:14px;font-family:Calibri-Bold" id="text378" class="st15 st38" x="225.0891" y="851.62427">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.35560012" d="m 233.9,861.71855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 40.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st46" inkscape:connector-curvature="0" id="F_SLC25A10_3" /><text style="font-size:16px;font-family:Calibri-Bold" id="text381" class="st15 st16" x="541.16345" y="867.11346">OAA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text383" class="st15 st16" x="444.4646" y="817.42017">AcCoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text385" class="st15 st16" x="552.0061" y="801.70825">Cit</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text387" class="st15 st16" x="584.02271" y="750.14575">Isocit</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text389" class="st15 st16" x="720.78931" y="750.92017">AKG</text> <text style="font-size:10px;font-family:Calibri" id="text391" class="st17 st18" x="618.72882" y="720.4563">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text393" class="st17 st18" x="647.54321" y="718.54126">NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text395" class="st17 st18" x="620.67413" y="781.10181">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text397" class="st17 st18" x="649.48175" y="783.26978">NADH</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text399" class="st15 st16" x="762.93884" y="808.12225">SuCoA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text401" class="st15 st16" x="768.40649" y="883.388">Succ</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text403" class="st15 st16" x="702.18781" y="941.1272">Fum</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text405" class="st15 st16" x="578.7005" y="921.75116">Mal</text> <path style="fill:none;stroke:#000000;stroke-width:2.04839993" d="m 566.7,779.01855 c -1.3,6.1 -1.3,6.1 -1.3,6.1 l 4.5,-4.4 -2.3,0.5 -0.9,-2.2 z" class="st47" inkscape:label="backward aconitase" inkscape:connector-curvature="0" id="B_ACO2_ACO1_1" /><path style="fill:none;stroke:#000000;stroke-width:1.12699997" d="m 566.9,782.01855 c 4.6,-9.3 11.1,-17.4 19,-23.8" class="st48" inkscape:connector-curvature="0" id="R_ACO2_ACO1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.04839993" d="m 585.4,760.31855 c 3.7,-5 3.7,-5 3.7,-5 l -5.8,2.2 2.3,0.5 -0.2,2.3 z" class="st47" inkscape:label="forward aconitase" inkscape:connector-curvature="0" id="F_ACO2_ACO1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.04839993" d="m 613.2,930.01855 c -5.9,-2.2 -5.9,-2.2 -5.9,-2.2 l 3.7,5 -0.1,-2.3 2.3,-0.5 z" class="st47" inkscape:label="forward fumarase" inkscape:connector-curvature="0" id="F_FH_1" /><path style="fill:none;stroke:#000000;stroke-width:1.53830004" d="m 750,753.21855 c 11.4,9.5 20.7,21.6 27.4,35.6 m 7.1,-13.7 c -5.5,3.4 -13.1,1.9 -17.3,-3.3 -4.2,-5.2 -3.5,-12.4 1.5,-16.3" class="st49" inkscape:label="DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" inkscape:connector-curvature="0" id="R_DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" /><text style="font-size:10px;font-family:Calibri" id="text412" class="st17 st18" x="770.49744" y="758.63306">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text414" class="st17 st18" x="788.89093" y="758.63306">+</text> <text style="font-size:10px;font-family:Calibri" id="text416" class="st17 st18" x="793.8714" y="758.63306">CoA</text> <path style="fill:none;stroke:#000000;stroke-width:1.4921" d="m 804.5,854.61855 c -5.7,0.4 -11.1,-2.1 -14.1,-6.4 -3,-4.3 -3,-9.8 -0.1,-14.1 2.9,-4.3 8.3,-6.9 14,-6.5 m -18.4,38.9 c 3.7,-17.5 3.4,-35.7 -0.7,-53.3" class="st50" inkscape:connector-curvature="0" id="R_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><text style="font-size:10px;font-family:Calibri" id="text419" class="st17 st18" x="812.39685" y="828.55005">GDP</text> <text style="font-size:10px;font-family:Calibri" id="text421" class="st17 st18" x="830.02374" y="828.55005">+</text> <text style="font-size:10px;font-family:Calibri" id="text423" class="st17 st18" x="835.00421" y="828.55005">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text425" class="st17 st18" x="814.06671" y="857.71606">GTP</text> <text style="font-size:10px;font-family:Calibri" id="text427" class="st17 st18" x="830.36554" y="857.71606">+</text> <text style="font-size:10px;font-family:Calibri" id="text429" class="st17 st18" x="835.34601" y="857.71606">CoA</text> <path style="fill:none;stroke:#000000;stroke-width:1.41170001" d="m 762.8,933.01855 c -4.7,-2.1 -7.7,-6.5 -7.5,-11.2 0.2,-4.7 3.4,-8.9 8.2,-10.5 4.8,-1.7 10.3,-0.5 14,2.9 m -2.6,-22 c -9,15.5 -21.4,28.8 -36.4,39.2" class="st51" inkscape:connector-curvature="0" id="R_SDHA_SDHB_SDHC_SDHD" /><text style="font-size:10px;font-family:Calibri" id="text432" class="st17 st18" x="784.63501" y="920.19165">FAD</text> <text style="font-size:10px;font-family:Calibri" id="text434" class="st17 st18" x="764.34894" y="943.30975">FADH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text436" class="st17 st26" x="786.55115" y="945.30975">2</text> <path style="fill:none;stroke:#000000;stroke-width:1.37870002" d="m 578.6,907.21855 c -8.4,-8.4 -15,-18.8 -19.3,-30.4 m -8,12 c 3.1,-2 7.4,-2.3 10.9,-0.8 3.6,1.6 5.8,4.7 5.8,8.2 0,3.4 -2.2,6.6 -5.8,8" class="st52" inkscape:connector-curvature="0" id="R_MDH2" /><text style="font-size:10px;font-family:Calibri" id="text439" class="st17 st18" x="537.08234" y="912.11646">NAD</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text441" class="st15 st16" x="451.4158" y="732.70825">Pyr</text> <path style="fill:none;stroke:#000000;stroke-width:2.24370003" d="m 464.2,739.41855 0.2,56.6 m -0.5,-21.6 c 1.5,5.9 13.6,4.1 13.6,4.1 m -13.3,-14.1 c 1.5,5.9 13.4,4.1 13.4,4.1 m -13.1,1.8 c -1.6,-6 -12.9,-5.2 -12.9,-5.2 m 12.4,-12.6 c -1.5,-6 -12.4,-5.2 -12.4,-5.2 m 12.7,6.1 c 1.5,5.9 13.2,4.1 13.2,4.1" class="st53" inkscape:label="DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB " inkscape:connector-curvature="0" id="R_DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB" /><text style="font-size:10px;font-family:Calibri" id="text444" class="st17 st18" x="567.64972" y="846.81366">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text446" class="st17 st26" x="573.88025" y="848.81366">2</text> <text style="font-size:10px;font-family:Calibri" id="text448" class="st17 st18" x="576.96814" y="846.81366">O</text> <text style="font-size:10px;font-family:Calibri" id="text450" class="st17 st18" x="569.51593" y="825.74438">CoA</text> <text style="font-size:10px;font-family:Calibri" id="text452" class="st17 st18" x="695.72681" y="780.76196">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text454" class="st17 st26" x="707.5921" y="782.76196">2</text> <text style="font-size:10px;font-family:Calibri" id="text456" class="st17 st18" x="696.48865" y="719.4046">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text458" class="st17 st26" x="708.35382" y="721.4046">2</text> <path style="fill:none;stroke:#000000;stroke-width:2.04839993" d="m 664.2,952.91855 c 5.8,2.2 5.8,2.2 5.8,2.2 l -3.7,-5 0.1,2.3 -2.2,0.5 z m 27.9,-11.2 c 4.9,-3.8 4.9,-3.8 4.9,-3.8 l -6.2,0.6 2,1.1 -0.7,2.1 z" class="st47" inkscape:connector-curvature="0" id="B_FH_1" /><path style="fill:none;stroke:#000000;stroke-width:1.84920001" d="m 666.6,952.31855 -16.4,-9.8 m 41.7,-2.8 c -33.5,7.3 -52.1,2.6 -79.1,-8.8" class="st54" inkscape:connector-curvature="0" id="R_FH_1" /><text style="font-size:10px;font-family:Calibri" id="text462" class="st17 st18" x="672.46021" y="961.96796">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text464" class="st17 st26" x="678.69073" y="963.96796">2</text> <text style="font-size:10px;font-family:Calibri" id="text466" class="st17 st18" x="681.7796" y="961.96796">O</text> <path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 561.8,902.51855 c -4,4 -4,4 -4,4 l 5.5,-0.9 -1.9,-1 0.4,-2.1 z m 13.6,3.9 c 6,1.7 6,1.7 6,1.7 l -4.1,-4.7 0.3,2.3 -2.2,0.7 z" class="st55" inkscape:connector-curvature="0" id="B_MDH2" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 739.7,928.21855 c -4.1,4.7 -4.1,4.7 -4.1,4.7 l 6,-1.7 -2.2,-0.7 0.3,-2.3 z m 21.4,5.7 c 5.3,1.4 5.3,1.4 5.3,1.4 l -3.6,-4.5 0.3,2.3 -2,0.8 z" class="st55" inkscape:connector-curvature="0" id="F_SDHA_SDHB_SDHC_SDHD" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 774.9,896.21855 c 1.3,-6.1 1.3,-6.1 1.3,-6.1 l -4.4,4.4 2.3,-0.5 0.8,2.2 z m 1.2,19.4 c 6.1,1.1 6.1,1.1 6.1,1.1 l -4.5,-4.3 0.5,2.2 -2.1,1 z" class="st55" inkscape:connector-curvature="0" id="B_SDHA_SDHB_SDHC_SDHD" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 785.2,863.01855 c 0.1,6.2 0.1,6.2 0.1,6.2 l 3.3,-5.3 -2.1,1 -1.3,-1.9 z m 18.8,-7 c 6.1,-1.5 6.1,-1.5 6.1,-1.5 l -5.9,-2 1.4,1.8 -1.6,1.7 z" class="st55" inkscape:connector-curvature="0" id="F_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 788.1,817.61855 c -3.6,-5.1 -3.6,-5.1 -3.6,-5.1 l 0.2,6.2 1.2,-2 2.2,0.9 z m 14.8,11.6 c 6,-1.6 6,-1.6 6,-1.6 l -5.9,-1.9 1.5,1.8 -1.6,1.7 z" class="st55" inkscape:connector-curvature="0" id="B_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text473" class="st15 st16" x="177.26639" y="802.27655">Fum</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text475" class="st15 st16" x="283.87378" y="800.91235">Fum</text> <path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 275.8,797.81855 -60.2,-0.3 m 44.6,0.2 c 5.9,-1.6 4.4,-15.3 4.4,-15.3 m -31.3,15.6 c -6.4,-4.5 -7.8,-15.5 -5,-15.5" class="st45" inkscape:connector-curvature="0" id="R_SLC25A10_4" /><path style="fill:none;stroke:#000000;stroke-width:2.0158999" d="m 229.9,783.11855 c -2.1,-4.9 -2.1,-4.9 -2.1,-4.9 l -2,5 2.1,-1.3 2,1.2 z m 44.1,16.7 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st56" inkscape:label=" B SLC25A10_4" inkscape:connector-curvature="0" id="B_SLC25A10_4" /><path style="fill:none;stroke:#000000;stroke-width:2.00889993" d="m 267,783.11855 c -1.6,-5.3 -1.6,-5.3 -1.6,-5.3 l -2.3,5.1 2,-1.2 1.9,1.4 z m -50.7,12.4 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st57" inkscape:label="F SLC25A10_4" inkscape:connector-curvature="0" id="F_SLC25A10_4" /><text style="font-size:14px;font-family:Calibri-Bold" id="text480" class="st15 st38" x="260.33328" y="777.0979">Pi</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text482" class="st15 st38" x="222.5813" y="777.03638">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text484" class="st17 st18" x="482.52859" y="702.16626">H</text> <text style="font-size:10px;font-family:Calibri" id="text486" class="st17 st18" x="444.9617" y="668.1311">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text488" class="st15 st16" x="465.6225" y="1131.1801">NAD</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text490" class="st15 st16" x="499.44772" y="1131.5101">QH</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text492" class="st15 st40" x="520.51807" y="1134.7103">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text494" class="st15 st16" x="396.8374" y="1133.059">5 H</text> <path style="fill:none;stroke:#000000;stroke-width:1.26660001" d="m 380.1998,1138.2711 0,17.7 133.5,0 0,-17.7 m -104.6,-1.6 0,18.7 m 26.7,-18.1 0,18.2 m 49,0 0,-17 m -13,17 0,28.6" class="st58" inkscape:connector-curvature="0" id="R_Complex1ROS" inkscape:label="#R_Complex1ROS" /><text style="font-size:16px;font-family:Calibri-Bold" id="text505" class="st15 st16" x="580.42444" y="1130.2744">2 Cytc-ox</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text507" class="st15 st16" x="738.55164" y="1130.0198">2 Cytc-red</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text509" class="st15 st16" x="834.18854" y="1130.3486">Q</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text511" class="st15 st16" x="667.68347" y="1131.8838">2H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text513" class="st15 st16" x="702.59131" y="1130.5463">QH</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text515" class="st15 st40" x="723.66162" y="1135.3677">2</text> <path style="fill:none;stroke:#000000;stroke-width:1.29487193" d="m 643.71124,1137.3649 0,18.3 195.54681,0 0,-18.3 m -159.78839,-0.3 0,18.2 m 41.6057,-17.5 0,17.4 m 65.782,0.1 0,-15.3 m -27.54973,15.6 0,24.5" class="st60" inkscape:connector-curvature="0" id="R_Complex3" /><text style="font-size:16px;font-family:Calibri-Bold" id="text518" class="st15 st16" x="746.68384" y="1199.0907">4 H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text520" class="st15 st16" x="888.39905" y="1132.1252">4 Cytc-red</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text522" class="st15 st16" x="1039.7281" y="1131.0266">4 Cytc-ox</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text524" class="st15 st16" x="1123.9191" y="1132.1672">2H</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text526" class="st15 st40" x="1145.7395" y="1135.3684">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text528" class="st15 st16" x="1150.6809" y="1132.1672">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text530" class="st15 st16" x="981.8186" y="1132.9836">8H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text532" class="st15 st16" x="1011.5463" y="1132.6321">O</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text534" class="st15 st40" x="1022.3666" y="1135.8323">2</text> <path style="fill:none;stroke:#000000;stroke-width:1.18280005" d="m 951.7,1138.8186 0,16.2 192.2,0 0,-16.2 m -152.2,-0.5 0,16.2 m 26.6,-15.7 0,15.8 m 53.3,-0.1 0,-13.8 m -23.8,13.8 0,25.4" class="st61" inkscape:connector-curvature="0" id="R_Complex4" /><text style="font-size:16px;font-family:Calibri-Bold" id="text537" class="st15 st16" x="1035.0892" y="1196.552">4 H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text539" class="st15 st16" x="890.96515" y="866.2962">CO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text541" class="st15 st40" x="910.13702" y="869.4964">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text543" class="st15 st16" x="962.79913" y="866.07635">HCO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text545" class="st15 st40" x="992.0647" y="869.27655">3</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text547" class="st15 st40" x="997.0061" y="857.27655">-</text> <path style="fill:none;stroke:#000000;stroke-width:2.06990004" d="m 929.8,861.11855 c -6.3,1.9 -5.8,15.6 -5.8,15.6 m 12.8,-15.5 c 6.4,1.4 4.8,12.8 4.8,12.8 m 11,-13 -36,-0.3" class="st62" inkscape:connector-curvature="0" id="R_CA5B_CA5A" /><text style="font-size:10px;font-family:Calibri" id="text550" class="st17 st18" x="938.54132" y="886.07739">H</text> <text style="font-size:10px;font-family:Calibri" id="text552" class="st17 st18" x="913.19171" y="885.12616">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text554" class="st17 st26" x="919.42224" y="887.12616">2</text> <text style="font-size:10px;font-family:Calibri" id="text556" class="st17 st18" x="922.51105" y="885.12616">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1170.1,1230.7186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="Glucose_DM_COOP b" inkscape:connector-curvature="0" id="B_Glucose_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1172.1,1229.4186 0.7,48.1" class="st14" inkscape:label="Glucose_DM_COOP" inkscape:connector-curvature="0" id="R_Glucose_DM_COOP" /><a transform="translate(1273.3622,1205.6018)" xlink:href="http://www.genome.jp/dbget-bin/www_bget?cpd:C00031" id="a14384-0"><text style="font-size:16px;font-family:Calibri-Bold" id="text561" class="st15 st16" transform="translate(-116.0982,12.7041)">Glc</text> </a><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 501.1,1274.6186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="Ex_SC_H2O f" inkscape:connector-curvature="0" id="F_Ex_SC_H2O" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 503.2,1227.4186 0,47.6" class="st63" inkscape:label="Ex_SC_H2O" inkscape:connector-curvature="0" id="R_Ex_SC_H2O" /><text style="font-size:16px;font-family:Calibri-Bold" id="text565" class="st15 st16" x="488.92899" y="1219.1184">H</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text567" class="st15 st40" x="499.02267" y="1222.3176">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text569" class="st15 st16" x="503.96512" y="1219.1184">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.67510009" d="m 561.7,1232.4186 -2.2,-7.1 -2.2,7.1 2.2,-1.8 2.2,1.8 z" class="st64" inkscape:label="Ex_O2 b" inkscape:connector-curvature="0" id="B_Ex_O2" /><path style="fill:none;stroke:#000000;stroke-width:2.67510009" d="m 559.6,1278.6186 0,-46.6" class="st64" inkscape:label="Ex_O2" inkscape:connector-curvature="0" id="R_Ex_O2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text573" class="st15 st16" x="553.19659" y="1218.1301">O</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text575" class="st15 st40" x="564.01691" y="1221.3303">2</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1236.1431,1273.3107 -2.2,7.3 -2.2,-7.3 2.2,1.8 2.2,-1.8 z" class="st14" inkscape:label="Glutamine_DM_COOP f" inkscape:connector-curvature="0" id="F_Glutamine_DM_COOP" /><text style="font-size:16px;font-family:Calibri-Bold" id="text579" class="st15 st16" x="1219.5931" y="1218.3059">Gln</text> <path style="fill:none;stroke:#000000;stroke-width:3.16359997" d="m 643.8,1274.6186 2.2,6.9 2.2,-6.9 -2.2,1.7 -2.2,-1.7 z" class="st65" inkscape:label="forward Ex_NH3 " inkscape:connector-curvature="0" id="F_Ex_NH3" /><path style="fill:none;stroke:#000000;stroke-width:3.36989999" d="m 645.9,1223.3186 0,51.7" class="st66" inkscape:label="Ex_NH3 " inkscape:connector-curvature="0" id="R_Ex_NH3" /><text style="font-size:16px;font-family:Calibri-Bold" id="text583" class="st15 st16" x="635.18091" y="1219.1711">NH</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text585" class="st15 st40" x="655.81384" y="1222.3713">3</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 841.2,1232.3186 2.2,-7.3 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="DM_Folate f" inkscape:connector-curvature="0" id="F_DM_Folate" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 843.5,1276.7186 -0.3,-48.1" class="st14" inkscape:label="DM_Folate" inkscape:connector-curvature="0" id="R_DM_Folate" /><text style="font-size:16px;font-family:Calibri-Bold" id="text589" class="st15 st16" x="821.54034" y="1218.8098">Folate</text> <path style="fill:none;stroke:#000000;stroke-width:2.31469989" d="m 689.2,1223.4186 0,56.6" class="st67" inkscape:label="DM_Urea" inkscape:connector-curvature="0" id="R_DM_Urea" /><text style="font-size:16px;font-family:Calibri-Bold" id="text592" class="st15 st16" x="672.34991" y="1218.9426">Urea</text> <path style="fill:none;stroke:#000000;stroke-width:2.22029996" d="m 890.5,1223.6186 0.3,50.4" class="st68" inkscape:label="DM_putrescine" inkscape:connector-curvature="0" id="R_DM_putrescine" /><text style="font-size:16px;font-family:Calibri-Bold" id="text595" class="st15 st16" x="873.35284" y="1219.4836">Putr</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text597" class="st15 st16" x="1115.0238" y="1218.8967">Lact</text> <path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1141.3465,1230.8815 -2.2,-7.7 -2.2,7.7 2.2,-1.9 2.2,1.9 z" class="st69" inkscape:label="LactateL_DM_COOP b" inkscape:connector-curvature="0" id="B_LactateL_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 501.1,1232.3186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="Ex_SC_H2O b" inkscape:connector-curvature="0" id="B_Ex_SC_H2O" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 532.3,1274.6186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="forward Ex_SC_H " inkscape:connector-curvature="0" id="F_Ex_SC_H" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 534.4,1227.4186 0,47.6" class="st63" inkscape:label="Ex_SC_Hs" inkscape:connector-curvature="0" id="R_Ex_SC_Hs" /><text style="font-size:16px;font-family:Calibri-Bold" id="text604" class="st15 st16" x="529.56775" y="1219.1184">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 532.3,1232.3186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="backward Ex_SC_H " inkscape:connector-curvature="0" id="B_Ex_SC_H" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 687.5,1275.3186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="DM_Urea f" inkscape:connector-curvature="0" id="F_DM_Urea" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 888.7,1273.2186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="DM_putrescine f" inkscape:connector-curvature="0" id="F_DM_putrescine" /><text style="font-size:16px;font-family:Calibri-Bold" id="text609" class="st15 st16" x="1258.4867" y="1218.8098">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1267.4,1273.3186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="Glutamate_DM_COOP f" inkscape:connector-curvature="0" id="F_Glutamate_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1270,1225.4186 0,50.5" class="st69" inkscape:label="Glutamate_DM_COOP" inkscape:connector-curvature="0" id="R_Glutamate_DM_COOP" /><text style="font-size:16px;font-family:Calibri-Bold" id="text613" class="st15 st16" x="1294.558" y="1219.0598">Arg</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 1305.8,1231.5186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" class="st63" inkscape:label="Arginine_DM_COOP f" inkscape:connector-curvature="0" id="F_Arginine_DM_COOP" /><text style="font-size:16px;font-family:Calibri-Bold" id="text616" class="st15 st16" x="577.40161" y="1218.1838">CO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text618" class="st15 st40" x="598.57355" y="1221.384">2</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 590,1229.9186 0,47.6" class="st63" inkscape:label="DM_CO2c" inkscape:connector-curvature="0" id="R_DM_CO2c" /><text style="font-size:16px;font-family:Calibri-Bold" id="text622" class="st15 st16" x="615.26984" y="1219.7141">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 620.5,1233.9186 0,47.6" class="st63" inkscape:label="Ex_SC_Pi " inkscape:connector-curvature="0" id="R_Ex_SC_Pi" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 620.6,1232.5186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" class="st63" inkscape:label="Ex_SC_Pi b" inkscape:connector-curvature="0" id="B_Ex_SC_Pi" /><path style="fill:none;stroke:#000000;stroke-width:1.96669996" d="m 587.5,1271.4186 1.9,6.8 1.9,-6.8 -1.9,1.7 -1.9,-1.7 z" class="st70" inkscape:label="FORWARD DM_CO2c" inkscape:connector-curvature="0" id="F_DM_CO2c" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 618.6,1275.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="Ex_SC_Pi f" inkscape:connector-curvature="0" id="F_Ex_SC_Pi" /><path style="fill:none;stroke:#000000;stroke-width:2.13409996" d="m 927.4,1281.5186 -0.8,-56.3" class="st71" inkscape:label="DM_guanidinoacetatec" inkscape:connector-curvature="0" id="R_DM_guanidinoacetatec" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 927.19047,1278.0186 -2.3,-1.7 2.4,7.2 2,-7.3 -2.1,1.8 z" class="st63" inkscape:label="DM_guanidinoacetatec f" inkscape:connector-curvature="0" id="F_DM_guanidinoacetatec" /><text style="font-size:15.99923611px;font-family:Calibri-Bold" id="text630" class="st15 st16" transform="matrix(0.99984771,-0.01745156,0.01745156,0.99984771,0,0)" x="896.45245" y="1235.1273">GA</text> <text style="font-size:10px;font-family:Calibri" id="text632" class="st17 st18" x="813.1839" y="294.34796">Asp</text> <text style="font-size:10px;font-family:Calibri" id="text634" class="st17 st18" x="847.99152" y="294.67303">2 ATP</text> <text style="font-size:10px;font-family:Calibri" id="text636" class="st17 st18" x="838.64294" y="261.41425">QH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text638" class="st17 st26" x="851.60181" y="263.41425">2</text> <text style="font-size:10px;font-family:Calibri" id="text640" class="st17 st18" x="859.31573" y="261.81076">2 ADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text642" class="st15 st16" x="950.24341" y="283.13986">UMP</text> <text style="font-size:10px;font-family:Calibri" id="text644" class="st17 st18" x="792.67413" y="295.08524">Gln</text> <text style="font-size:10px;font-family:Calibri" id="text646" class="st17 st18" x="800.29321" y="261.82446">Glu</text> <text style="font-size:10px;font-family:Calibri" id="text648" class="st17 st18" x="886.02863" y="294.47684">HCO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text650" class="st17 st26" x="904.12433" y="296.47684">3</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text652" class="st17 st26" x="907.2132" y="288.97684">-</text> <text style="font-size:10px;font-family:Calibri" id="text654" class="st17 st18" x="835.15265" y="294.92795">Q</text> <text style="font-size:10px;font-family:Calibri" id="text656" class="st17 st18" x="875.8938" y="294.94363">H</text> <text style="font-size:10px;font-family:Calibri" id="text658" class="st17 st18" x="906.9231" y="262.21405">PPi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text660" class="st15 st16" x="953.64874" y="337.59396">UDP</text> <text style="font-size:10px;font-family:Calibri" id="text662" class="st17 st18" x="995.4729" y="301.37915">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text664" class="st17 st18" x="985.13312" y="312.31955">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:1.5819" d="m 937.8,332.81855 c -4.7,-0.3 -6.5,-11.7 -6.5,-11.7 m 21.4,11.5 -31.2,0.2" class="st72" inkscape:label="RRM2B_TXN_RRM1_RRM2_1" inkscape:connector-curvature="0" id="R_RRM2B_TXN_RRM1_RRM2_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text667" class="st15 st16" x="872.57452" y="337.33325">dUDP</text> <text style="font-size:10px;font-family:Calibri" id="text669" class="st17 st18" x="920.89093" y="314.44846">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text671" class="st17 st26" x="927.1214" y="316.44846">2</text> <text style="font-size:10px;font-family:Calibri" id="text673" class="st17 st18" x="930.21021" y="314.44846">O</text> <text style="font-size:16.00037575px;font-family:Calibri-Bold" id="text675" class="st15 st16" transform="matrix(0.99997657,-0.0068447,0.0068447,0.99997657,0,0)" x="779.65546" y="343.09702">dUMP</text> <text style="font-size:10px;font-family:Calibri" id="text677" class="st17 st18" transform="matrix(0.99990048,0.01410788,-0.01410788,0.99990048,0,0)" x="852.72308" y="304.24103">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text679" class="st17 st18" transform="matrix(0.9998951,-0.01448404,0.01448404,0.9998951,0,0)" x="827.13593" y="328.46188">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text681" class="st17 st18" x="923.82745" y="262.21405">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text683" class="st17 st26" x="935.69275" y="264.21405">2</text> <text style="font-size:16.0006218px;font-family:Calibri-Bold" id="text685" class="st15 st16" transform="matrix(0.99976114,-0.02185571,0.02185571,0.99976114,0,0)" x="673.61633" y="353.25659">dTMP</text> <text style="font-size:10.00026512px;font-family:Calibri" id="text687" class="st17 st18" transform="matrix(0.99997352,-0.00727731,0.00727731,0.99997352,0,0)" x="748.1861" y="319.31909">meTHF</text> <text style="font-size:10.00010777px;font-family:Calibri" id="text689" class="st17 st18" transform="matrix(0.99998921,0.00464547,-0.00464547,0.99998921,0,0)" x="731.41992" y="310.3287">DHF</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text691" class="st15 st16" x="1025.2386" y="337.24924">UTP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text693" class="st15 st16" x="1113.8793" y="337.43964">CTP</text> <text style="font-size:10px;font-family:Calibri" id="text695" class="st17 st18" x="1079.4359" y="317.43384">ADP+Pi</text> <text style="font-size:10px;font-family:Calibri" id="text697" class="st17 st18" x="1039.0609" y="317.67896">ATP+NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text699" class="st17 st26" x="1071.7709" y="319.67896">3</text> <text style="font-size:10px;font-family:Calibri" id="text701" class="st17 st18" x="1163.5892" y="316.63016">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text703" class="st17 st18" x="1144.7562" y="317.36545">ADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text705" class="st15 st16" x="1185.2777" y="337.33524">CDP</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1157.5,324.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" class="st73" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" inkscape:connector-curvature="0" id="B_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1174.1,335.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" class="st22" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" inkscape:connector-curvature="0" id="F_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><text style="font-size:16px;font-family:Calibri-Bold" id="text709" class="st15 st16" x="1258.7123" y="337.35764">CMP</text> <path style="fill:none;stroke:#000000;stroke-width:2.43479991" d="m 1198.8,339.01855 -0.1,22.4 m -0.1,-17.5 c -0.2,5.3 -9.5,7.3 -9.5,7.3" class="st74" inkscape:connector-curvature="0" id="R_RRM2B_TXN_RRM1_RRM2_2" /><text style="font-size:10px;font-family:Calibri" id="text712" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1168.255" y="353.44818">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text714" class="st17 st26" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1174.4854" y="355.44815">2</text> <text style="font-size:10px;font-family:Calibri" id="text716" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1177.5743" y="353.44812">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text718" class="st15 st16" x="1175.5306" y="382.04416">dCDP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text720" class="st15 st16" x="360.74741" y="449.50314">3PPyr</text> <text style="font-size:10px;font-family:Calibri" id="text722" class="st17 st18" x="410.62479" y="426.49734">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text724" class="st17 st18" x="435.24878" y="426.49734">+</text> <text style="font-size:10px;font-family:Calibri" id="text726" class="st17 st18" x="440.22931" y="426.49734">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.33130002" d="m 446.2,443.81855 -34.2,0.2 m 20.4,0.1 c -4.3,-0.3 -6,-12.3 -6,-12.3 m 3.8,12.1 c 6.1,1.5 5.6,12.5 5.6,12.5" class="st75" inkscape:label="PHGDH_UBAC2 " inkscape:connector-curvature="0" id="R_PHGDH_UBAC2" /><text style="font-size:10px;font-family:Calibri" id="text729" class="st17 st18" x="427.62769" y="465.14575">NAD</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text731" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="356.75916" y="399.59976">3PSer</text> <text style="font-size:10px;font-family:Calibri" id="text733" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="345.07333" y="429.83682">Glu</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text735" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="333.53885" y="420.90979">AKG</text> <path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 377,437.71855 -0.2,-34.2 m -15.7,11.7 c 9.7,-2.9 16,3.2 16,3.2 m -0.2,3.4 c -1.4,5.3 -16.7,5.1 -16.7,5.1" class="st76" inkscape:connector-curvature="0" id="R_PSAT1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 379.1,403.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -14,12.2 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:connector-curvature="0" id="F_PSAT1" /><path style="fill:none;stroke:#000000;stroke-width:2.23519993" d="m 379.2,351.31855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" class="st77" inkscape:label="VPS29_PSPH_PSPHP1 forward" inkscape:connector-curvature="0" id="F_VPS29_PSPH_PSPHP1" /><text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text740" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="359.90805" y="346.62714">Ser</text> <text style="font-size:10px;font-family:Calibri" id="text742" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="393.64661" y="374.83282">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text744" class="st17 st26" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="399.87701" y="376.83292">2</text> <text style="font-size:10px;font-family:Calibri" id="text746" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="402.96588" y="374.83289">O</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text748" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="395.1853" y="368.10416">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 377,367.81855 c 0.6,2.3 3,3.4 5.1,4.1 2.9,0.8 6,1.1 9,1.1 m 1.7,-11.8 c -5.4,-1.7 -11.7,-0.5 -16,3.2 m 0.3,19.3 c -0.1,-11.4 -0.1,-22.8 -0.2,-34.2" class="st76" inkscape:label="VPS29_PSPH_PSPHP1 " inkscape:connector-curvature="0" id="R_VPS29_PSPH_PSPHP1" /><text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text751" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="360.82996" y="259.71588">Gly</text> <text style="font-size:10px;font-family:Calibri" id="text753" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="399.81461" y="284.13171">THF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 390.2,284.61855 c 7,-1.3 7,-1.3 7,-1.3 l -6.8,-1.9 1.7,1.7 -1.9,1.5 z m -15.6,36.9 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z" class="st73" inkscape:connector-curvature="0" id="B_SHMT1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 425.5,435.31855 c -0.5,-7.1 -0.5,-7.1 -0.5,-7.1 l 3.5,6.2 -2,-1.2 -1,2.1 z m -11.7,11 c -6.3,-2.2 -6.3,-2.2 -6.3,-2.2 l 6.5,-1.7 -1.7,1.9 1.5,2 z" class="st73" inkscape:label="PHGDH_UBAC2 forward" inkscape:connector-curvature="0" id="F_PHGDH_UBAC2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text757" class="st15 st16" x="422.2869" y="341.40353">Pyr</text> <text style="font-size:10px;font-family:Calibri" id="text759" class="st17 st18" x="396.70538" y="319.50906">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text761" class="st17 st26" x="409.3909" y="321.50906">3</text> <path style="fill:none;stroke:#000000;stroke-width:2.38170004" d="m 398.5,338.71855 c 3.7,-0.3 5.1,-10.5 5.1,-10.5 m -16.8,10.6 26.2,-0.2" class="st78" inkscape:connector-curvature="0" id="R_SDS_SDSL_SRR" /><text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text764" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="141.05353" y="304.02942">DHF</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text766" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="136.36797" y="245.96878">Folate</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 158.1,279.71855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="DHFRL1_DHFR_2 forward" inkscape:connector-curvature="0" id="F_DHFRL1_DHFR_2" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 159.9,281.31855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" class="st79" inkscape:label="DHFRL1_DHFR_2 " inkscape:connector-curvature="0" id="R_DHFRL1_DHFR_2" /><text style="font-size:10px;font-family:Calibri" id="text770" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="184.45857" y="280.61414">NADP</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text772" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="179.325" y="260.32965">NADPH</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text774" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="179.32498" y="272.82965">+H</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text776" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="141.77278" y="368.62994">THF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 157.7,343.41855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="DHFRL1_DHFR_4 forward" inkscape:connector-curvature="0" id="F_DHFRL1_DHFR_4" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 159.5,345.01855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.2,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" class="st79" inkscape:label="DHFRL1_DHFR_4 " inkscape:connector-curvature="0" id="R_DHFRL1_DHFR_4" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 161.5,312.61855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m 9.7,7.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="DHFRL1_DHFR_4 " inkscape:connector-curvature="0" id="B_DHFRL1_DHFR_4" /><text style="font-size:10px;font-family:Calibri" id="text781" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="181.55092" y="341.92856">NADP</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text783" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="177.77963" y="322.29248">NADPH</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text785" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="177.77962" y="334.79254">+H</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text787" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="122.12817" y="433.13483">10-formyl</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text789" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="141.62041" y="453.13483">THF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 157.3,407.81855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 foward" inkscape:connector-curvature="0" id="F_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 159,409.41855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" class="st79" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 " inkscape:connector-curvature="0" id="R_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 161.1,377.01855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m 9.7,7.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 backward" inkscape:connector-curvature="0" id="B_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><text style="font-size:10px;font-family:Calibri" id="text794" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="181.41222" y="406.33478">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text796" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="198.51668" y="406.33478">+</text> <text style="font-size:10px;font-family:Calibri" id="text798" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="203.49713" y="406.33481">Pi</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text800" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="176.62868" y="387.771">for+ATP</text> <path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 221.4,395.51855 c 1.4,5.3 17.3,5.1 17.3,5.1 m -1.6,-19.7 c -9.7,-2.9 -16,3.2 -16,3.2 m -14.9,44.3 14.4,0 0,-68 -39.6,0" class="st79" inkscape:label="MTHFD1_3 " inkscape:connector-curvature="0" id="R_MTHFD1_3" /><text style="font-size:10px;font-family:Calibri" id="text803" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="250.68755" y="398.89441">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text805" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="274.24716" y="398.89441">+</text> <text style="font-size:10px;font-family:Calibri" id="text807" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="250.68761" y="411.39444">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text809" class="st17 st26" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="256.91809" y="413.39441">2</text> <text style="font-size:10px;font-family:Calibri" id="text811" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="260.00687" y="411.39438">O</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text813" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="242.4368" y="378.47998">NADPH+</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text815" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="242.43677" y="390.98007">H+CO</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text817" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="265.513" y="392.98007">2</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text819" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="261.84116" y="348.57727">mTHF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09509993" d="m 204.8,436.41855 79.8,0 0,-84 m 16,24.7 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" class="st80" inkscape:connector-curvature="0" id="R_MTHFD1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 296,378.11855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -9.3,-24.4 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" class="st73" inkscape:label="MTHFD1_1 forward" inkscape:connector-curvature="0" id="F_MTHFD1_1" /><text style="font-size:10px;font-family:Calibri" id="text823" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="309.67828" y="399.18741">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 299.8,398.21855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -93.6,36.5 c -6.3,2.3 -6.3,2.3 -6.3,2.3 l 6.5,1.7 -1.7,-1.9 1.5,-2.1 z" class="st73" inkscape:connector-curvature="0" id="B_MTHFD1_1" /><text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text826" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="254.19125" y="282.20911">meTHF</text> <path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 277.6,301.91855 c -1.6,-5.3 -17.5,-4.5 -17.5,-4.5 m 2.3,19.7 c 9.8,2.5 15.9,-3.8 15.9,-3.8 m 0.3,11.1 -0.2,-34.2" class="st79" inkscape:label="MTHFD2_1 " inkscape:connector-curvature="0" id="R_MTHFD2_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 280.6,292.01855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -15.6,3.3 c -7,1.6 -7,1.6 -7,1.6 l 6.9,1.6 -1.7,-1.6 1.8,-1.6 z" class="st73" inkscape:label="MTHFD2_1 forward" inkscape:connector-curvature="0" id="F_MTHFD2_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 266.3,316.11855 c -7,1.6 -7,1.6 -7,1.6 l 6.9,1.6 -1.7,-1.6 1.8,-1.6 z m 10.5,6.6 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z" class="st73" inkscape:label="MTHFD2_1 backward" inkscape:connector-curvature="0" id="B_MTHFD2_1" /><rect style="fill:none;stroke:#231f20;stroke-width:7;stroke-linejoin:round;stroke-miterlimit:2" height="487.10001" width="1218.2" class="st81" y="682.21857" x="248.5" id="rect3188" /><text style="font-size:10px;font-family:Calibri" id="text832" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="229.13246" y="320.30942">NADPH</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text834" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="229.66826" y="302.43216">NADP</text> <text style="font-size:16.0003109px;font-family:Calibri-Bold" id="text836" class="st15 st16" transform="matrix(0.9999806,0.00622953,-0.00622953,0.9999806,0,0)" x="748.04932" y="1068.5068">DHF</text> <text style="font-size:15.99927998px;font-family:Calibri-Bold" id="text838" class="st15 st16" transform="matrix(0.99984501,-0.01760548,0.01760548,0.99984501,0,0)" x="629.1507" y="1083.5598">Folate</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 730.9,1070.9186 c 7.4,-2 7.4,-2 7.4,-2 l -7.2,-2.3 1.8,2.2 -2,2.1 z m -2.4,-14.1 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:label="DHFRL1_DHFR_5 forward" inkscape:connector-curvature="0" id="F_DHFRL1_DHFR_5" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 732.5,1069.2186 -34.2,0 m 8.6,-15.9 c -2.9,9.6 3.1,16 3.1,16 m 11.4,-0.2 c 5.3,-1.4 5.2,-17.3 5.2,-17.3" class="st79" inkscape:label="DHFRL1_DHFR_5 " inkscape:connector-curvature="0" id="R_DHFRL1_DHFR_5" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 700.1,1066.9186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 7.6,-9.7 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:label="DHFRL1_DHFR_5 backward" inkscape:connector-curvature="0" id="B_DHFRL1_DHFR_5" /><text style="font-size:9.99962521px;font-family:Calibri" id="text843" class="st17 st18" transform="matrix(0.9997375,0.02291141,-0.02291141,0.9997375,0,0)" x="744.8653" y="1031.0618">NADP</text> <text style="font-size:9.9998436px;font-family:Calibri" id="text845" class="st17 st18" transform="matrix(0.99991568,-0.012986,0.012986,0.99991568,0,0)" x="662.83777" y="1056.4205">NADPH+H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text847" class="st15 st16" transform="matrix(0.99999758,-0.00219903,0.00219903,0.99999758,0,0)" x="825.8905" y="1075.1088">THF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 812.4,1070.3186 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z m -2.4,-14.1 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:label="DHFRL1_DHFR_6 forward" inkscape:connector-curvature="0" id="F_DHFRL1_DHFR_6" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 814,1068.5186 -34.2,0 m 8.6,-15.8 c -2.9,9.6 3.1,16 3.1,16 m 11.4,-0.2 c 5.3,-1.4 5.2,-17.3 5.2,-17.3" class="st79" inkscape:label="DHFRL1_DHFR_6 " inkscape:connector-curvature="0" id="R_DHFRL1_DHFR_6" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 781.6,1066.3186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 7.5,-9.7 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:label="DHFRL1_DHFR_6 backward" inkscape:connector-curvature="0" id="B_DHFRL1_DHFR_6" /><text style="font-size:10.00011921px;font-family:Calibri" id="text852" class="st17 st18" transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" x="809.07843" y="1042.3011">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text854" class="st17 st18" transform="matrix(0.99999791,-0.00204595,0.00204595,0.99999791,0,0)" x="756.18549" y="1047.5868">NADPH+H</text> <text style="font-size:16.00077438px;font-family:Calibri-Bold" id="text856" class="st15 st16" transform="matrix(0.99995156,0.00984282,-0.00984282,0.99995156,0,0)" x="919.18933" y="1061.8497">10-formylTHF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 895.7,1056.5186 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z m 2.4,14.1 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z" class="st73" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2 forward" inkscape:connector-curvature="0" id="F_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 888.6,1068.8186 c 5.3,-1.4 5.2,-17.3 5.2,-17.3 m -19.7,1.5 c -2.9,9.6 3.1,16 3.1,16 m 22.5,-0.1 -34.2,0" class="st79" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2" inkscape:connector-curvature="0" id="R_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 875.1,1056.9186 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z m -7.6,9.7 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" class="st73" inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2 backward" inkscape:connector-curvature="0" id="B_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text861" class="st15 st16" transform="matrix(0.9999915,0.00412203,-0.00412203,0.9999915,0,0)" x="805.01166" y="1025.8337">mTHF</text> <path style="fill:none;stroke:#000000;stroke-width:1.3247" d="m 900.4,1026.9186 c 5.3,-1.1 5.2,-13.8 5.2,-13.8 m -19.8,1.2 c -3,7.7 3.2,12.8 3.2,12.8 m 44.5,25.3 0.6,-25.4 -84.3,-0.1" class="st82" inkscape:connector-curvature="0" id="R_MTHFD1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 853.1,1024.7186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 33.5,-9 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:connector-curvature="0" id="F_MTHFD1_2" /><text style="font-size:10px;font-family:Calibri" id="text865" class="st17 st18" transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" x="876.94342" y="1005.7078">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text867" class="st17 st26" transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" x="883.17377" y="1007.7078">2</text> <text style="font-size:10px;font-family:Calibri" id="text869" class="st17 st18" transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" x="886.2627" y="1005.7078">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 931.6,1049.1186 c 2.2,6.3 2.2,6.3 2.2,6.3 l 1.7,-6.5 -1.9,1.7 -2,-1.5 z m -24.1,-33.9 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" class="st73" inkscape:connector-curvature="0" id="B_MTHFD1_2" /><text style="font-size:16.00037193px;font-family:Calibri-Bold" id="text872" class="st15 st16" transform="matrix(0.99997671,0.00682482,-0.00682482,0.99997671,0,0)" x="707.71307" y="1025.7979">meTHF</text> <path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 791.2,1026.6186 -34.2,0 m 26.8,-15.4 c 2.6,9.7 -3.7,15.9 -3.7,15.9 m -11.3,-0.6 c -5.3,-1.6 -4.6,-17.4 -4.6,-17.4" class="st79" inkscape:connector-curvature="0" id="R_MTHFD2_4" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 762.1,1013.9186 c 1.5,-7 1.5,-7 1.5,-7 l 1.7,6.9 -1.6,-1.7 -1.6,1.8 z m -3.3,10.5 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" class="st73" inkscape:connector-curvature="0" id="F_MTHFD2_4" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 789.6,1028.4186 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z m -6.7,-13.3 c 1.5,-7 1.5,-7 1.5,-7 l 1.7,6.9 -1.6,-1.7 -1.6,1.8 z" class="st73" inkscape:connector-curvature="0" id="B_MTHFD2_4" /><text style="font-size:10px;font-family:Calibri" id="text877" class="st17 st18" transform="matrix(0.99989917,0.01420008,-0.01420008,0.99989917,0,0)" x="790.88013" y="994.28802">NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text879" class="st17 st18" transform="matrix(0.99990781,0.01357832,-0.01357832,0.99990781,0,0)" x="760.42932" y="995.04498">NADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text881" class="st15 st16" x="315.19269" y="786.4632">OAA</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text883" class="st15 st16" x="942.22101" y="658.15649">Gln</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text885" class="st15 st16" x="1033.4213" y="658.15649">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:1.56400001" d="m 969.4,653.91855 53.9,0 m -19.5,0.5 c 4.6,-0.4 6.2,-11.9 6.2,-11.9 m -5.5,11.7 c -4.5,0.5 -6.6,11.7 -6.6,11.7" class="st83" inkscape:label="GLS2" inkscape:connector-curvature="0" id="R_GLS2" /><text style="font-size:10px;font-family:Calibri" id="text888" class="st17 st18" x="1000.8987" y="636.82635">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text890" class="st17 st26" x="1013.5844" y="638.82635">3</text> <text style="font-size:10px;font-family:Calibri" id="text892" class="st17 st18" x="983.43292" y="674.4173">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text894" class="st17 st26" x="989.66345" y="676.4173">2</text> <text style="font-size:10px;font-family:Calibri" id="text896" class="st17 st18" x="992.7522" y="674.4173">O</text> <text style="font-size:10px;font-family:Calibri" id="text898" class="st17 st18" x="1035.5336" y="601.31757">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text900" class="st17 st18" x="1022.9135" y="638.01587">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text902" class="st17 st18" x="989.93292" y="602.9173">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text904" class="st17 st26" x="1002.6184" y="604.9173">3</text> <text style="font-size:10px;font-family:Calibri" id="text906" class="st17 st18" x="980.08435" y="638.513">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.11560011" d="m 1050.4,645.51855 0,-29.9 -92.5,0 0,24 m 78.9,-24.4 c 5,-1.2 4.3,-13.1 4.3,-13.1 m -4.2,12.8 c -5.2,1 -5.3,9.2 -5.3,9.2 m -44,-8.8 c -3.7,0.9 -3.8,9 -3.8,9 m 11,-8.5 c 5,-1.1 4.3,-12 4.3,-12" class="st84" inkscape:label="#R_gln_synthetase" inkscape:connector-curvature="0" id="R_GS" /><path style="fill:none;stroke:#000000;stroke-width:1.39260006" d="m 956.3,660.51855 0,32.4 m 0.4,-9.9 c -2.6,2.5 9.5,6.9 9.5,6.9 m -10,-12.7 c 0.4,-4.4 -9.3,-7.5 -9.3,-7.5" class="st85" inkscape:label="TransportGln" inkscape:connector-curvature="0" id="R_TransportGln" /><path style="fill:none;stroke:#000000;stroke-width:1.12300003" d="m 1052,660.31855 0,32.2 m 0.1,-12.3 c 0.1,5.1 9.8,8.5 9.8,8.5 m -9.9,-9.3 c 0.2,-4.1 -8.4,-8.3 -8.4,-8.3" class="st86" inkscape:label="TransportGlu" inkscape:connector-curvature="0" id="R_TransportGlu" /><text style="font-size:9.87795448px;font-family:Calibri" id="text911" class="st17 st87" transform="scale(1.0123241,0.98782595)" x="926.31677" y="681.64825">H</text> <text style="font-size:9.87795448px;font-family:Calibri" id="text913" class="st17 st87" transform="scale(1.0123241,0.98782595)" x="962.82196" y="702.19128">H</text> <text style="font-size:10px;font-family:Calibri" id="text915" class="st17 st18" x="1032.5765" y="674.64575">H</text> <text style="font-size:10px;font-family:Calibri" id="text917" class="st17 st18" x="1070.2865" y="694.58521">H</text> <text style="font-size:15.80470657px;font-family:Calibri-Bold" id="text919" class="st15 st88" transform="scale(1.0123241,0.98782595)" x="932.36621" y="721.383">Gln</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text921" class="st15 st16" x="1040.6478" y="712.59686">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:2.09260011" d="m 969.6,707.11855 63.5,0 m -30.7,0.2 c 5.9,-0.2 7.8,-7.5 7.8,-7.5 m -12.1,7.6 c -4.6,-0.4 -6.8,-9.9 -6.8,-9.9" class="st89" inkscape:connector-curvature="0" id="R_GLS" /><text style="font-size:10px;font-family:Calibri" id="text924" class="st17 st18" x="1006.3949" y="693.48657">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text926" class="st17 st26" x="1019.0804" y="695.48657">3</text> <text style="font-size:10px;font-family:Calibri" id="text928" class="st17 st18" x="982.98663" y="694.27856">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text930" class="st17 st26" x="989.2171" y="696.27856">2</text> <text style="font-size:10px;font-family:Calibri" id="text932" class="st17 st18" x="992.30591" y="694.27856">O</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text934" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1331.6912" y="771.82178">NH</text> <text style="font-size:9.7501936px;font-family:Calibri-Bold" id="text936" class="st15 st40" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1352.3239" y="775.02191">3</text> <path style="fill:none;stroke:#000000;stroke-width:1.76709998" d="m 1189,777.11855 0.5,-30.4 m 10.5,7.1 c -8.9,1.1 -11.1,9.1 -11.1,9.1 m 0.2,-0.1 c -0.5,5.2 10.5,8.6 10.5,8.6" class="st90" inkscape:connector-curvature="0" id="R_OTC_LEFTY1" /><text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text939" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1180.2643" y="782.81091">Orn</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text941" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1187.484" y="728.58057">Ci</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text943" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1187.3484" y="635.12445">Ci</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text945" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1153.5397" y="588.43402">ArgSuc</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text947" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1223.7125" y="571.21527">Arg</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text949" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1230.6833" y="630.91748">Orn</text> <text style="font-size:10px;font-family:Calibri" id="text951" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1132.3175" y="625.07318">Asp</text> <text style="font-size:10px;font-family:Calibri" id="text953" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1147.2687" y="625.07312">+</text> <text style="font-size:10px;font-family:Calibri" id="text955" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="1152.249" y="625.07312">ATP</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text957" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1113.4318" y="629.14063">AMP</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text959" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1132.9337" y="629.1405">+</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text961" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1137.9142" y="629.14056">PPi</text> <path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 1179.6,616.11855 c -2.6,-4.9 -15,-1.2 -15,-1.2 m 1.5,11.8 c 10.1,0.2 14.5,-7.4 14.5,-7.4 m -1.1,-15.4 c -3,15.1 4.9,26.9 4.9,26.9" class="st76" inkscape:label="ASS1 " inkscape:connector-curvature="0" id="R_ASS1" /><text style="font-size:10.00030041px;font-family:Calibri" id="text964" class="st17 st18" transform="matrix(0.99427012,-0.10689679,0.10689679,0.99427012,0,0)" x="1114.6914" y="680.83099">Fum</text> <path style="fill:none;stroke:#000000;stroke-width:1.79009998" d="m 1214.6,571.01855 c -16.6,-3.2 -28.6,8.8 -28.6,8.8 m 7.5,-5.6 c 5.9,-1.9 4.1,-12.3 4.1,-12.3" class="st91" inkscape:connector-curvature="0" id="R_ASL_CRCP" /><path style="fill:none;stroke:#000000;stroke-width:1.92120004" d="m 1248.2,621.11855 c 4.6,-20.3 -6.2,-36.5 -6.2,-36.5 m 18.6,3.2 c -9,-1.2 -13.6,6 -13.6,6 m 0.3,3.6 c 2,3.5 14.6,1.8 14.6,1.8" class="st92" inkscape:connector-curvature="0" id="R_ARG2_ARG1" /><text style="font-size:9.99962234px;font-family:Calibri" id="text968" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1254.6495" y="601.48828">H</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text970" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1260.88" y="603.48834">2</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text972" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1263.9689" y="601.48822">O</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text974" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1262.8811" y="616.68073">Urea</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1186.7,576.11855 c -4.8,5.9 -4.8,5.9 -4.8,5.9 l 7.2,-2.4 -2.7,-0.7 0.3,-2.8 z" class="st73" inkscape:label="ASL_CRCP backward" inkscape:connector-curvature="0" id="B_ASL_CRCP" /><path style="fill:none;stroke:#000000;stroke-width:1.3319" d="m 1199,562.51855 c -1.6,-4.9 -1.6,-4.9 -1.6,-4.9 l -1,4.9 1.2,-1.2 1.4,1.2 z m 11.8,10.5 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z" class="st93" inkscape:label="ASL_CRCP forward" inkscape:connector-curvature="0" id="F_ASL_CRCP" /><path style="fill:none;stroke:#000000;stroke-width:2.13980007" d="m 1190.5,651.51855 0.1,71.7 m -0.3,-53.8 c 2.4,5.4 15.3,4 15.3,4 m -15.4,-12.9 c 2.4,5.4 15.3,4 15.3,4 m -14.9,35.9 c 1.9,-5.6 15,-5.4 15,-5.4 m -14.6,17.1 c 1.9,-5.6 15,-5.4 15,-5.4" class="st94" inkscape:label="SLC25A15_SLC25A2_1" inkscape:connector-curvature="0" id="R_SLC25A15_SLC25A2_1" /><text style="font-size:14px;font-family:Calibri-Bold" id="text979" class="st15 st38" transform="matrix(0.99980805,-0.01959226,0.01959226,0.99980805,0,0)" x="1201.152" y="721.48889">H</text> <text style="font-size:13.99942493px;font-family:Calibri-Bold" id="text981" class="st15 st38" transform="matrix(0.99984109,-0.01782667,0.01782667,0.99984109,0,0)" x="1201.3977" y="733.09906">Orn</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text983" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1287.2751" y="577.22217">Putr</text> <path style="fill:none;stroke:#000000;stroke-width:1.36409998" d="m 1256.3,636.01855 41.1,0 0,-40.3 m 10.7,7.5 c -6.7,-1.2 -10.2,6.1 -10.2,6.1" class="st95" inkscape:connector-curvature="0" id="R_OGDH_ODC1_OGDHL" /><text style="font-size:9.99962234px;font-family:Calibri" id="text986" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1308.797" y="620.35846">CO</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text988" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1320.6622" y="622.35846">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text990" class="st15 st16" x="1340.1732" y="712.76776">GluSA</text> <text style="font-size:10px;font-family:Calibri" id="text992" class="st17 st18" x="1268.7523" y="692.13495">AKG</text> <text style="font-size:10px;font-family:Calibri" id="text994" class="st17 st18" x="1299.0814" y="692.05975">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1306.2,700.71855 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.7,6.9 1.6,-1.7 1.5,1.8 z m 21.3,8.8 c 6.3,-2.2 6.3,-2.2 6.3,-2.2 l -6.5,-1.7 1.7,1.9 -1.5,2 z" class="st73" inkscape:connector-curvature="0" id="F_OAT" /><path style="fill:none;stroke:#000000;stroke-width:2.21600008" d="m 1239.8,707.61855 88.2,0.1 m -28.6,-0.2 c 5.4,-0.7 4.9,-7.6 4.9,-7.6 m -21.6,-4.9 c -1.9,7.9 4.4,12.5 4.4,12.5" class="st96" inkscape:connector-curvature="0" id="R_OAT" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1359,688.51855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.7,-6.5 -1.9,1.7 -2.1,-1.5 z" class="st73" inkscape:label="Transport_Lglu5semialdehyde backward" inkscape:connector-curvature="0" id="B_Transport_Lglu5semialdehyde" /><path style="fill:none;stroke:#000000;stroke-width:2.34100008" d="m 1361,668.81855 0.2,20" class="st97" inkscape:label="Transport_Lglu5semialdehyde " inkscape:connector-curvature="0" id="R_Transport_Lglu5semialdehyde" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1362.8,670.21855 c -0.7,-2.4 -1.3,-4.9 -2,-7.3 -0.8,2.4 -1.5,4.8 -2.3,7.3 0.7,-0.6 1.5,-1.2 2.2,-1.8 0.7,0.6 1.4,1.2 2.1,1.8 z" class="st73" inkscape:label="Transport_Lglu5semialdehyde forward" inkscape:connector-curvature="0" id="F_Transport_Lglu5semialdehyde" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1001" class="st15 st16" x="1336.557" y="658.23456">GluSA</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1358.4,637.01855 c 2,6.4 2,6.4 2,6.4 l 1.9,-6.4 -1.9,1.6 -2,-1.6 z" class="st73" inkscape:label="ALDH4A1_2 backward" inkscape:connector-curvature="0" id="B_ALDH4A1_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1004" class="st15 st16" x="1352.6332" y="608.19745">P5C</text> <path style="fill:none;stroke:#000000;stroke-width:1.24119997" d="m 1360.4,618.41855 0.1,20.4 m 0.1,-8.4 c -3,-6.6 -10.4,-6.2 -10.4,-6.2" class="st98" inkscape:connector-curvature="0" id="R_ALDH4A1_2" /><text style="font-size:9.99962234px;font-family:Calibri" id="text1007" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1319.298" y="638.0332">H</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text1009" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1325.5284" y="640.03333">2</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1011" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1328.6173" y="638.03326">O</text> <text style="font-size:10px;font-family:Calibri" id="text1013" class="st17 st18" transform="matrix(0.99990761,-0.01359275,0.01359275,0.99990761,0,0)" x="1371.2954" y="643.84912">NADH+H</text> <text style="font-size:10px;font-family:Calibri" id="text1015" class="st17 st18" transform="matrix(0.99939509,-0.03477735,0.03477735,0.99939509,0,0)" x="1397.1116" y="673.6972">NAD</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1017" class="st15 st16" x="1442.0248" y="606.54315">Pro</text> <text style="font-size:10.00029469px;font-family:Calibri" id="text1019" class="st17 st18" transform="matrix(0.99987054,0.01609049,-0.01609049,0.99987054,0,0)" x="1389.0287" y="630.53644">NADPH+H</text> <text style="font-size:9.99974251px;font-family:Calibri" id="text1021" class="st17 st18" transform="matrix(0.99922571,-0.03934428,0.03934428,0.99922571,0,0)" x="1378.6187" y="707.83429">NADP</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1023" class="st17 st18" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="1286.8578" y="776.54065">NADH</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1025" class="st17 st18" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="1311.4819" y="776.54071">+</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1027" class="st17 st18" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="1316.4624" y="776.54065">H</text> <text style="font-size:10px;font-family:Calibri" id="text1029" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="1303.4719" y="727.08441">NAD+H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1031" class="st17 st26" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="1333.0753" y="729.08441">2</text> <text style="font-size:10px;font-family:Calibri" id="text1033" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="1336.1642" y="727.08441">O</text> <path style="fill:none;stroke:#000000;stroke-width:1.78269994" d="m 1360.8,720.31855 0.3,32.5 m -0.2,-19.6 c -1.4,-5 -10.8,-3.5 -10.8,-3.5 m 0.6,11.6 c 7.1,2 10.7,-4.9 10.7,-4.9" class="st99" inkscape:connector-curvature="0" id="R_ALDH4A1_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1036" class="st15 st16" x="1350.3373" y="771.66528">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1358.9,750.41855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.7,-6.5 -1.9,1.7 -2.1,-1.5 z m -6.9,-10.7 c -7.1,0.9 -7.1,0.9 -7.1,0.9 l 6.8,2.3 -1.6,-1.8 1.9,-1.4 z" class="st73" inkscape:connector-curvature="0" id="B_ALDH4A1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1351,728.11855 c -6.9,1.7 -6.9,1.7 -6.9,1.7 l 7,1.5 -1.8,-1.6 1.7,-1.6 z m 11.8,-3.7 c -0.7,-2.4 -1.3,-4.9 -2,-7.3 -0.8,2.4 -1.5,4.8 -2.3,7.3 0.7,-0.6 1.5,-1.2 2.2,-1.8 0.7,0.5 1.4,1.2 2.1,1.8 z" class="st73" inkscape:connector-curvature="0" id="F_ALDH4A1_1" /><text style="font-size:10px;font-family:Calibri" id="text1040" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="888.26978" y="706.72406">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text1042" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="906.66333" y="706.72406">+</text> <text style="font-size:10px;font-family:Calibri" id="text1044" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="888.2688" y="719.22406">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1046" class="st17 st26" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="894.50018" y="721.22406">2</text> <text style="font-size:10px;font-family:Calibri" id="text1048" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="897.58905" y="719.224">O</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1050" class="st17 st18" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="824.83246" y="730.75824">NADH+</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1052" class="st17 st18" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="824.83344" y="743.2583">H+NH</text> <text style="font-size:6.0936017px;font-family:Calibri" id="text1054" class="st17 st26" transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" x="848.72894" y="745.25824">3</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 935,761.21855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.7 -1.6,-1.6 z m -171.9,-16.2 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st73" inkscape:connector-curvature="0" id="B_GLUD1_GLUD2_2" /><path style="fill:none;stroke:#000000;stroke-width:1.86580002" d="m 941.8,747.41855 c -6.2,1.5 -5.1,14.4 -5.1,14.4 m 21.3,0.1 c 2.7,-9 -4.9,-14.5 -4.9,-14.5 m 103.9,-26.4 c 0,26.3 0,26.3 0,26.3 l -295.7,0" class="st100" inkscape:connector-curvature="0" id="R_GLUD1_GLUD2_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1059,725.01855 c -2.3,-7.3 -2.3,-7.3 -2.3,-7.3 l -2.1,7.3 2.1,-1.9 2.3,1.9 z m -102.6,36.5 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.7 -1.6,-1.6 z" class="st73" inkscape:connector-curvature="0" id="F_GLUD1_GLUD2_2" /><text style="font-size:10px;font-family:Calibri" id="text1059" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="956.75903" y="773.34814">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text1061" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="980.31866" y="773.34814">+</text> <text style="font-size:10px;font-family:Calibri" id="text1063" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="956.75903" y="785.84802">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1065" class="st17 st26" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="962.9895" y="787.84808">2</text> <text style="font-size:10px;font-family:Calibri" id="text1067" class="st17 st18" transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" x="966.07831" y="785.84814">O</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1069" class="st17 st18" transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" x="892.81866" y="799.80231">NADPH+</text> <text style="font-size:9.99983883px;font-family:Calibri" id="text1071" class="st17 st18" transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" x="892.81866" y="812.30237">H+NH</text> <text style="font-size:6.0936017px;font-family:Calibri" id="text1073" class="st17 st26" transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" x="916.71509" y="814.30231">3</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text1075" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="610.36102" y="1009.088">Ser</text> <text style="font-size:15.99982166px;font-family:Calibri-Bold" id="text1077" class="st15 st16" transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" x="714.42944" y="1011.3351">Gly</text> <text style="font-size:10px;font-family:Calibri" id="text1079" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="652.00781" y="1022.0663">THF</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 660.6,1009.4186 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z m -2.4,-14.10005 c -7.3,2 -7.3,2 -7.3,2 l 7.3,2.3 -1.8,-2.2 1.8,-2.1 z" class="st73" inkscape:label="SHMT1_2 backward" inkscape:connector-curvature="0" id="B_SHMT1_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1082" class="st15 st16" x="316.81769" y="625.53351">Asp</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1084" class="st15 st16" x="317.24249" y="728.39868">Asp</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1086" class="st15 st16" x="301.33231" y="669.98846">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1088" class="st15 st16" x="289.33328" y="654.96118">Glu</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1090" class="st15 st16" x="359.73318" y="710.5979">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1092" class="st15 st16" x="356.95441" y="697.87531">Glu</text> <path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 330.6,717.91855 0.2,-81.5 m 0,65.8 c 1.9,5.9 17.6,4.4 17.6,4.4 m -34.6,-41.3 c 5,-3.9 17.8,4.8 17.8,4.8 m -17.9,-17.1 c 4.7,-4.2 18.1,3.8 18.1,3.8 m -1,32.6 c 1.9,5.9 17.6,4.4 17.6,4.4" class="st45" inkscape:label="SLC25A13_SLC25A12" inkscape:connector-curvature="0" id="R_SLC25A13_SLC25A12" /><path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 345.2,696.41855 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z m -12.3,-57.1 c -2.3,-7.2 -2.3,-7.2 -2.3,-7.2 l -2,7.3 2.1,-1.9 2.2,1.8 z m 13.2,69.9 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z" class="st45" inkscape:label="#SLC25A13_SLC25A12" inkscape:connector-curvature="0" id="F_SLC25A13_SLC25A12" /><path style="fill:none;stroke:#000000;stroke-width:2.49320006" d="m 1491.4,754.31855 -49,-0.2" class="st101" inkscape:label="Transport_serine " inkscape:connector-curvature="0" id="R_Transport_serine" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1443.1,752.01855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st22" inkscape:label="Transport_serine f" inkscape:connector-curvature="0" id="F_Transport_serine" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1098" class="st15 st16" x="1409.9398" y="758.43781">Ser</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1100" class="st15 st16" x="1501.6996" y="758.50806">Ser</text> <path style="fill:none;stroke:#000000;stroke-width:2.48900008" d="m 1490.5,773.81855 -48.1,-0.2" class="st102" inkscape:label="Transport_glycine " inkscape:connector-curvature="0" id="R_Transport_glycine" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1443.1,771.51855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st22" inkscape:label="Transport_glycine backward" inkscape:connector-curvature="0" id="B_Transport_glycine" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1489.9,775.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:transform-center-y="-3.0492074" inkscape:transform-center-x="0.87100132" inkscape:label="Transport_glycine forward" inkscape:connector-curvature="0" id="F_Transport_glycine" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1105" class="st15 st16" x="1408.141" y="776.79517">Gly</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1107" class="st15 st16" x="1502.0004" y="777.33026">Gly</text> <path style="fill:none;stroke:#000000;stroke-width:2.51880002" d="m 1497,792.51855 -55.2,-0.2" class="st103" inkscape:label="TransportFolate" inkscape:connector-curvature="0" id="R_TransportFolate" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1442.5,790.21855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st22" inkscape:label="TransportFolate f" inkscape:connector-curvature="0" id="F_TransportFolate" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1111" class="st15 st16" x="1386.1674" y="797.35956">Folate</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1113" class="st15 st16" x="1501.8568" y="795.38885">Folate</text> <path style="fill:none;stroke:#000000;stroke-width:2.49620008" d="m 1491.2,812.71855 -49.7,-0.2" class="st104" inkscape:label="SLC16A3_SLC16A1_SLC16A5_2 " inkscape:connector-curvature="0" id="R_SLC16A3_SLC16A1_SLC16A5_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1116" class="st15 st16" x="1375.0873" y="814.86646">Formate</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1118" class="st15 st16" x="1501.4066" y="815.80499">Formate</text> <text style="font-size:10px;font-family:Calibri" id="text1120" class="st17 st18" x="485.40158" y="115.15945">ATP</text> <path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 467.4,101.01855 c 0,31.2 0,31.2 0,31.2 m 11.4,-18.7 c -7,-2.9 -11.5,3.3 -11.5,3.3 m 0.2,3.4 c 0.8,5.5 10.2,5.3 10.2,5.3" class="st76" inkscape:label="GCK_HKDC1_HK1_ADPGK_HK2_HK3 " inkscape:connector-curvature="0" id="R_GCK_HKDC1_HK1_ADPGK_HK2_HK3" /><path style="fill:none;stroke:#000000;stroke-width:1.67910004" d="m 467.6,565.81855 0,27.6 0,-27.6 z m 0,12.8 c 0.9,5 10.8,4.8 10.8,4.8 m 0.5,-11 c -6.9,-2.7 -11.3,3 -11.3,3" class="st105" inkscape:connector-curvature="0" id="R_PKM_TMEM54_PKLR_HCN3" /><path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 467.4,210.91855 0,31.1 0,-31.1 z m 0.3,14.8 c 0.9,5.5 11.1,5.3 11.1,5.3 m 3.7,-11.9 c -8.8,-2.9 -14.6,3.3 -14.6,3.3" class="st76" inkscape:connector-curvature="0" id="R_PFKP_PFKL_PFKM_1" /><path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 463.2,324.21855 0,37.2 0,-37.2 z m -0.3,18.2 c 1,5.5 11.8,5.2 11.8,5.2 m 2.5,-13 c -8.1,-2.9 -13.4,3.3 -13.4,3.3" class="st76" inkscape:connector-curvature="0" id="R_GAPDHS_GAPDH_GAPDHP29" /><path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 467.3,389.21855 0,37.2 0,-37.2 z m 0.4,15.4 c 0.8,5.6 9.7,5.3 9.7,5.3 m 2.5,-11.9 c -7.3,-3 -12,3.4 -12,3.4" class="st76" inkscape:connector-curvature="0" id="R_CRISP3_PGK1_MIA3_PGK2" /><path style="fill:none;stroke:#000000;stroke-width:1.81210005" d="m 467,524.81855 c 1.1,4.4 13,4.2 13,4.2 m -13.1,-13 c 0,24.3 0,24.3 0,24.3" class="st106" inkscape:label="R_ENO1_ENO3_ENO2 " inkscape:connector-curvature="0" id="R_ENO1_ENO3_ENO2" /><path style="fill:none;stroke:#000000;stroke-width:1.58019996" d="m 479.9,153.01855 45.9,0 -45.9,0 z m 33,8.4 c 2.6,-5.3 -3.5,-8.6 -3.5,-8.6 m -16.6,0.1 c -4.9,1.2 -4.4,12.7 -4.4,12.7" class="st107" inkscape:connector-curvature="0" id="R_G6PD" /><path style="fill:none;stroke:#000000;stroke-width:1.53460002" d="m 565.3,154.11855 c 7.9,0 15.7,0 23.6,0 m -8.7,0.1 c -1.9,0.2 -3.2,1.9 -3.9,3.4 -1.3,2.6 -1.9,5.6 -2.3,8.5" class="st108" inkscape:connector-curvature="0" id="R_H6PD_PGLS" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 638.3,154.51855 46.1,0 -46.1,0 z m 36.6,9.4 c 2.4,-5.6 -3.7,-9.1 -3.7,-9.1 m -23.3,-0.2 c -5,1.1 -4.3,12 -4.3,12" class="st109" inkscape:connector-curvature="0" id="R_PGD" /><path style="fill:none;stroke:#000000;stroke-width:1.61259997" d="m 968,293.11855 -0.2,25.4 m 12.8,-19.5 c -8.2,-1.5 -12.6,4.8 -12.6,4.8 m 0,2.6 c 1.7,4.8 13.1,3 13.1,3" class="st110" inkscape:label="CMPK2_CMPK1_1" inkscape:connector-curvature="0" id="R_CMPK2_CMPK1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.54340005" d="m 759.4,333.41855 c 2.5,-0.6 3.4,-3.4 4,-5.6 0.5,-2.3 0.7,-4.7 0.7,-7 m -24.6,-0.6 c -1.6,4.5 -0.3,9.8 3.1,13.1 m -13.7,0 c 14.6,-0.1 29.2,-0.2 43.8,-0.3" class="st111" inkscape:connector-curvature="0" id="R_TYMS" /><path style="fill:none;stroke:#000000;stroke-width:1.75189996" d="m 1088.6,332.81855 c 5.1,-1 3.8,-8.7 3.8,-8.7 m -24.6,-2.4 c -1.7,7.1 3.5,11.2 3.5,11.2 m -16.1,0 49.8,0.2" class="st112" inkscape:connector-curvature="0" id="R_CTPS2_GATM_CTPS1" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 1146.5,332.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" class="st109" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" inkscape:connector-curvature="0" id="R_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1135" class="st15 st38" transform="matrix(0.99980805,-0.01959226,0.01959226,0.99980805,0,0)" x="1196.0963" y="700.7312">H</text> <text style="font-size:13.99942493px;font-family:Calibri-Bold" id="text1137" class="st15 st38" transform="matrix(0.99984109,-0.01782667,0.01782667,0.99984109,0,0)" x="1194.2786" y="688.07074">Orn</text> <path style="fill:none;stroke:#000000;stroke-width:1.52830005" d="m 1425.4,612.11855 c 1,-2.3 0.5,-5 -1.1,-6.9 -0.6,-0.7 -1.2,-1.3 -1.9,-1.8 m -20,0.2 c -2.5,0.5 -3.6,3.7 -4.1,6.4 -0.3,2 -0.5,4.1 -0.4,6.1 m 34.9,-12.9 c -16.4,0.1 -32.8,0.1 -49.1,0.2" class="st113" inkscape:connector-curvature="0" id="R_PYCRL_PYCR2_PYCR1_LEFTY1_1" /><path style="fill:none;stroke:#000000;stroke-width:1.80159998" d="m 1428.9,640.21855 c 0.3,-6.1 -4.8,-8.7 -4.8,-8.7 m -22.3,0.4 c -3.9,-1.2 -5.4,12.6 -5.4,12.6 m -21.7,-31.8 0,19 75.8,0.1 0,-19" class="st114" inkscape:connector-curvature="0" id="R_PYCRL_PYCR2_PYCR1_LEFTY1_2" /><path style="fill:none;stroke:#000000;stroke-width:3.13759995" d="m 1050.3,713.41855 c 0,26.9 0,26.9 0,26.9 l -293.5,0 m 98.1,-9.5 c -1.8,5.9 2.3,9.7 2.3,9.7 m 33.9,-0.2 c 3.4,-1.3 3.1,-14.8 3.1,-14.8" class="st115" inkscape:connector-curvature="0" id="R_GLUD1_GLUD2_1" /><text style="font-size:10px;font-family:Calibri" id="text1142" class="st17 st18" transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" x="904.09766" y="1005.4383">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1144" class="st15 st16" x="1486.4927" y="394.78244">PPi</text> <text style="font-size:10px;font-family:Calibri" id="text1146" class="st17 st18" x="1531.7222" y="374.82935">Pi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1148" class="st15 st16" x="1554.2847" y="394.81766">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text1150" class="st17 st18" x="1510.5044" y="374.69266">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1152" class="st17 st26" x="1516.7349" y="376.69266">2</text> <text style="font-size:10px;font-family:Calibri" id="text1154" class="st17 st18" x="1519.8237" y="374.69266">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1156" class="st15 st16" x="1484.4966" y="349.50125">CO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text1158" class="st15 st40" x="1503.6685" y="352.70145">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1160" class="st15 st16" x="1556.1343" y="349.02563">HCO</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text1162" class="st15 st40" x="1585.3999" y="352.22586">3</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text1164" class="st15 st40" x="1590.3413" y="340.22586">-</text> <path style="fill:none;stroke:#000000;stroke-width:1.80649996" d="m 1525.5,346.01855 c -5.4,-1.7 -4.9,-14 -4.9,-14 m 10.8,14.3 c 5.5,-1.1 4.1,-10.6 4.1,-10.6 m 9,10.6 -33.9,-0.3" class="st116" inkscape:label="CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" inkscape:connector-curvature="0" id="R_CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" /><text style="font-size:10px;font-family:Calibri" id="text1167" class="st17 st18" x="1532.2759" y="326.92114">H</text> <text style="font-size:10px;font-family:Calibri" id="text1169" class="st17 st18" x="1511.0825" y="328.17014">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1171" class="st17 st26" x="1517.313" y="330.17014">2</text> <text style="font-size:10px;font-family:Calibri" id="text1173" class="st17 st18" x="1520.4019" y="328.17014">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1424.9,550.31855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -9.1,-14.8 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.8,6.9 1.6,-1.7 1.6,1.8 z" class="st73" inkscape:label="AGAT forward" inkscape:connector-curvature="0" id="F_AGAT" /><path style="fill:none;stroke:#000000;stroke-width:2.16529989" d="m 1402.1,532.41855 c -2.7,9.7 3.5,15.9 3.5,15.9 m 3.4,-0.2 c 5.4,-1.2 4.9,-14.2 4.9,-14.2 m -25.2,14.2 39.4,0.1" class="st117" inkscape:connector-curvature="0" id="R_AGAT" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1391.4,546.31855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z m 11.6,-10 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.8,6.9 1.6,-1.7 1.6,1.8 z" class="st73" inkscape:label="AGAT backward" inkscape:connector-curvature="0" id="B_AGAT" /><text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text1178" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1439.4275" y="543.42334">Orn</text> <text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text1180" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1360.4196" y="542.20752">Arg</text> <text style="font-size:10.00020409px;font-family:Calibri" id="text1182" class="st17 st18" transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" x="1391.7148" y="578.39606">H</text> <text style="font-size:6.09382439px;font-family:Calibri" id="text1184" class="st17 st26" transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" x="1397.9453" y="580.39606">2</text> <text style="font-size:10.00020409px;font-family:Calibri" id="text1186" class="st17 st18" transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" x="1401.0333" y="578.396">O</text> <text style="font-size:10.000103px;font-family:Calibri" id="text1188" class="st17 st18" transform="matrix(0.99968968,0.0249107,-0.0249107,0.99968968,0,0)" x="1421.3773" y="552.20471">NH</text> <text style="font-size:6.09376287px;font-family:Calibri" id="text1190" class="st17 st26" transform="matrix(0.99968968,0.0249107,-0.0249107,0.99968968,0,0)" x="1434.0627" y="554.20477">3</text> <path style="fill:none;stroke:#000000;stroke-width:1.58570004" d="m 1372.7,556.21855 0,8 59.7,0 m -27.9,0.1 c -5.2,1.1 -4.6,11.9 -4.6,11.9 m 11.8,-2.8 c 1.3,-5.8 -4.6,-9 -4.6,-9" class="st118" inkscape:connector-curvature="0" id="R_arginineAmidinohydrolase" /><text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text1193" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1443.032" y="560.49847">Ci</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1195" class="st15 st16" x="141.67799" y="620.84399">Asn</text> <text style="font-size:10px;font-family:Calibri" id="text1197" class="st17 st18" x="169.63359" y="597.4563">Glu</text> <text style="font-size:10px;font-family:Calibri" id="text1199" class="st17 st18" x="183.491" y="597.4563">+</text> <text style="font-size:10px;font-family:Calibri" id="text1201" class="st17 st18" x="188.4715" y="597.4563">AMP</text> <text style="font-size:10px;font-family:Calibri" id="text1203" class="st17 st18" x="207.97339" y="597.4563">+</text> <text style="font-size:10px;font-family:Calibri" id="text1205" class="st17 st18" x="212.95389" y="597.4563">PPi</text> <text style="font-size:10px;font-family:Calibri" id="text1207" class="st17 st18" x="235.44168" y="597.802">Gln+ATP+H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1209" class="st17 st26" x="280.53448" y="599.802">2</text> <text style="font-size:10px;font-family:Calibri" id="text1211" class="st17 st18" x="283.6228" y="597.802">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.13490009" d="m 177.6,614.01855 c 45.3,0 90.7,0.1 136,0.1 m -53.3,-0.7 c 4.3,-2.2 4.3,-7.9 4.6,-12.1 l 0,-0.6 0,-0.5 m -62.9,4.2 c -1.9,3.5 0.5,7.2 3.5,9.1" class="st119" inkscape:connector-curvature="0" id="R_ASNS" /><text style="font-size:10px;font-family:Calibri" id="text1214" class="st17 st18" x="178.00999" y="646.13007">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1216" class="st17 st26" x="184.24049" y="648.13007">2</text> <text style="font-size:10px;font-family:Calibri" id="text1218" class="st17 st18" x="187.32939" y="646.13007">O</text> <text style="font-size:10px;font-family:Calibri" id="text1220" class="st17 st18" x="215.13109" y="645.87531">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1222" class="st17 st26" x="227.8167" y="647.87531">3</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1224" class="st15 st16" x="312.49149" y="443.98465">Fum</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1226" class="st15 st16" x="311.30301" y="503.79126">Mal</text> <text style="font-size:10px;font-family:Calibri" id="text1228" class="st17 st18" x="289.62579" y="470.02274">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1230" class="st17 st26" x="295.8562" y="472.02274">2</text> <text style="font-size:10px;font-family:Calibri" id="text1232" class="st17 st18" x="298.94458" y="470.02274">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1234" class="st15 st16" x="310.03931" y="565.5257">OAA</text> <text style="font-size:10px;font-family:Calibri" id="text1236" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="364.86237" y="538.48999">GTP</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1238" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="378.13837" y="544.30634">GDP+CO</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text1240" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="412.61111" y="546.30634">2</text> <path style="fill:none;stroke:#000000;stroke-width:2.3204" d="m 397.8,557.61855 c 6.3,-1 6,-11.8 6,-11.8 m -31.2,-3.5 c -2.3,9.4 2.6,15.5 2.6,15.5 m 62.1,-0.2 -98.3,0.2" class="st120" inkscape:connector-curvature="0" id="R_PEPCK" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1243" class="st15 st16" x="562.0647" y="582.62531">Iso</text> <text style="font-size:10px;font-family:Calibri" id="text1245" class="st17 st18" x="583.12042" y="558.49048">NADPH</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1247" class="st15 st16" x="666.13904" y="582.9212">AKG</text> <text style="font-size:10px;font-family:Calibri" id="text1249" class="st17 st18" x="584.34894" y="600.24438">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text1251" class="st17 st18" x="634.66632" y="558.13007">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1253" class="st17 st26" x="646.53149" y="560.13007">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1255" class="st15 st16" x="254.8035" y="672.10089">Fum</text> <text style="font-size:10px;font-family:Calibri" id="text1257" class="st17 st18" x="235.65359" y="644.21405">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1259" class="st17 st26" x="248.33908" y="646.21405">3</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1261" class="st15 st16" x="354.87671" y="645.8938">Ala</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 430.6,634.41855 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.7,6.9 1.6,-1.7 1.5,1.8 z m 25.2,-8.7 c -2.2,-6.3 -2.2,-6.3 -2.2,-6.3 l -1.7,6.5 1.9,-1.7 2,1.5 z" class="st73" inkscape:label="NIT2 b" inkscape:connector-curvature="0" id="B_NIT2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 410.3,635.21855 c -0.5,-2.3 -1,-4.7 -1.4,-7 -0.6,2.3 -1.2,4.6 -1.7,6.9 0.5,-0.6 1.1,-1.1 1.6,-1.7 0.4,0.6 1,1.2 1.5,1.8 l 0,0 z m -21.4,4.9 c -2.5,0.6 -4.9,1.3 -7.4,1.9 2.4,0.8 4.8,1.6 7.2,2.4 -0.6,-0.7 -1.2,-1.5 -1.8,-2.2 0.8,-0.7 1.4,-1.4 2,-2.1 l 0,0 z" class="st73" inkscape:label="NIT2" inkscape:connector-curvature="0" id="F_NIT2" /><text style="font-size:10px;font-family:Calibri" id="text1265" class="st17 st18" x="396.95239" y="626.41815">AKG</text> <text style="font-size:10px;font-family:Calibri" id="text1267" class="st17 st18" x="420.85379" y="626.40259">Glu</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1269" class="st15 st16" x="409.09311" y="1219.8303">Biomass</text> <path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 434.5,1275.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="biomass_synthesis f" inkscape:connector-curvature="0" id="F_biomass_synthesis" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 436.5,1224.9186 0,50.5" class="st69" inkscape:label="biomass_synthesis" inkscape:connector-curvature="0" id="R_biomass_synthesis" /><path style="fill:none;stroke:#000000;stroke-width:1.68139994" d="m 407.6,610.21855 c -5.4,-0.8 -5.1,-9.5 -5.1,-9.5 m 35.5,-3.8 c 2.8,7.9 -3.2,13.1 -3.2,13.1 m 14.4,-0.2 c -62.3,0 -62.3,0 -62.3,0" class="st121" inkscape:label="#R_LDHD" inkscape:connector-curvature="0" id="R_LDH" /><text style="font-size:10px;font-family:Calibri" id="text1274" class="st17 st18" x="657.13702" y="176.49825">NADPH+</text> <text style="font-size:10px;font-family:Calibri" id="text1276" class="st17 st18" x="657.13702" y="188.99825">H+CO2</text> <text style="font-size:10px;font-family:Calibri" id="text1278" class="st17 st18" x="498.32352" y="174.68045">NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text1280" class="st17 st18" x="528.11365" y="174.68045">+H</text> <text style="font-size:10px;font-family:Calibri" id="text1282" class="st17 st18" x="420.31329" y="593.42896">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1284" class="st17 st18" x="444.93729" y="593.42896">+</text> <text style="font-size:10px;font-family:Calibri" id="text1286" class="st17 st18" x="449.91779" y="593.42896">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.90479994" inkscape:connector-curvature="0" d="m 467.5,711.91855 -0.2,-89.3 m 0.3,71.6 c 1.4,5.7 13.2,4.2 13.2,4.2 m -13.5,-30 c -1.7,-4.3 -14.4,-3.9 -14.4,-3.9" class="st122" id="R_MPC1_MPC2_MPC1L" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 465,710.11855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.6,-6.5 -1.9,1.7 -2,-1.5 z" class="st73" inkscape:label="MPC1_MPC2_MPC1L forward" inkscape:connector-curvature="0" id="F_MPC1_MPC2_MPC1L" /><text style="font-size:10px;font-family:Calibri" id="text1290" class="st17 st18" x="432.4104" y="750.59888">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text1292" class="st17 st18" x="434.51151" y="767.7298">CoA</text> <text style="font-size:10px;font-family:Calibri" id="text1294" class="st17 st18" x="485.1048" y="782.6712">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1296" class="st17 st26" x="496.97" y="784.6712">2</text> <text style="font-size:10px;font-family:Calibri" id="text1298" class="st17 st18" x="484.4744" y="761.19745">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1300" class="st17 st18" x="485.61499" y="772.3714">H</text> <text style="font-size:10px;font-family:Calibri" id="text1302" class="st17 st18" x="580.08624" y="699.8714">Mal</text> <text style="font-size:10px;font-family:Calibri" id="text1304" class="st17 st18" x="520.5755" y="664.80096">Mal</text> <path style="fill:none;stroke:#000000;stroke-width:2.25819993" d="m 559.6,784.71855 -0.1,-252.5 m 0.1,159.4 c 1.4,5.6 13.3,4.2 13.3,4.2 m -13.4,-29.7 c -1.7,-4.2 -14.5,-3.9 -14.5,-3.9" class="st123" inkscape:label="SLC25A1" inkscape:connector-curvature="0" id="R_SLC25A1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1307" class="st15 st16" x="554.77374" y="523.11255">Cit</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 568.4,536.41855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="ACO1_IREB2 b" inkscape:connector-curvature="0" id="B_ACO1_IREB2" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 568.6,562.11855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st14" inkscape:label="ACO1_IREB2 f" inkscape:connector-curvature="0" id="F_ACO1_IREB2" /><path style="fill:none;stroke:#000000;stroke-width:1.92060006" d="m 570.4,535.51855 c 0,27.3 0,27.3 0,27.3" class="st124" inkscape:label="ACO1_IREB2" inkscape:connector-curvature="0" id="R_ACO1_IREB2" /><text style="font-size:10px;font-family:Calibri" id="text1312" class="st17 st18" x="887.51202" y="262.06564">2 Pi</text> <path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 477.8,123.71855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.4,8 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st30" inkscape:label="GCK_HKDC1_HK1_ADPGK_HK2_HK3 f" inkscape:connector-curvature="0" id="F_GCK_HKDC1_HK1_ADPGK_HK2_HK3" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 477.8,229.21855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12,10.7 c 1.7,7.3 1.7,7.3 1.7,7.3 l 1.7,-7.3 -1.7,1.8 -1.7,-1.8 z" class="st30" inkscape:label="PFKP_PFKL_PFKM_1 f" inkscape:connector-curvature="0" id="F_PFKP_PFKL_PFKM_1" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 473.7,345.71855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.6,13.6 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st30" inkscape:label="GAPDHS_GAPDH_GAPDHP29" inkscape:connector-curvature="0" id="F_GAPDHS_GAPDH_GAPDHP29" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 479.8,527.21855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -14.7,10.9 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st30" inkscape:label="ENO1_ENO3_ENO2 f" inkscape:connector-curvature="0" id="F_ENO1_ENO3_ENO2" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 477.9,581.61855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.4,10.4 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" class="st30" inkscape:label="PKM_TMEM54_PKLR_HCN3 f" inkscape:connector-curvature="0" id="F_PKM_TMEM54_PKLR_HCN3" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 403.9,602.11855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -15.8,5.8 -7.3,2.2 7.3,2.2 -1.8,-2.2 1.8,-2.2 z" class="st30" inkscape:label="LDH f" inkscape:connector-curvature="0" id="F_LDH" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 514.9,160.51855 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 6.5,-5.4 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z" class="st30" inkscape:label="G6PD" inkscape:connector-curvature="0" id="F_G6PD" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 676.8,162.21855 c -1,5.2 -1,5.2 -1,5.2 l -2.4,-5.3 1.9,1.3 1.5,-1.2 z m 5.2,-5.6 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z" class="st30" inkscape:label="PGD f" inkscape:connector-curvature="0" id="F_PGD" /><path style="fill:none;stroke:#000000;stroke-width:2.09750009" d="m 790.5,176.41855 c 0,29.5 0,29.5 0,29.5 m -12.7,-23.8 c 7.8,-2.3 12.6,3.5 12.6,3.5 m -0.3,7 c -1,5 -10.4,4.3 -10.4,4.3" class="st125" inkscape:label="PRPS2_PRPS1_PRPS1L1" inkscape:connector-curvature="0" id="R_PRPS2_PRPS1_PRPS1L1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 764.8,168.11855 c 7.2,-0.3 7.2,-0.3 7.2,-0.3 l -6.1,-3.9 1.1,2.6 -2.2,1.6 z" class="st32" inkscape:transform-center-y="13.19671" inkscape:transform-center-x="-17.870394" inkscape:label="RPIA_LOC101060545 f" inkscape:connector-curvature="0" id="F_RPIA_LOC101060545" /><path style="fill:none;stroke:#000000;stroke-width:1.17589998" d="m 732.7,157.71855 33.8,8.2" class="st126" inkscape:transform-center-y="9.1713454" inkscape:transform-center-x="7.5511886" inkscape:label="RPIA_LOC101060545" inkscape:connector-curvature="0" id="R_RPIA_LOC101060545" /><path style="fill:none;stroke:#000000;stroke-width:1.13479996" d="m 739,148.51855 32,-6.4" class="st127" inkscape:transform-center-y="-9.5755519" inkscape:transform-center-x="6.2972653" inkscape:label="RPE_LOC729020" inkscape:connector-curvature="0" id="R_RPE_LOC729020" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 740.3,146.41855 c -6.6,2.9 -6.6,2.9 -6.6,2.9 l 7.1,1.5 -1.9,-2 1.4,-2.4 z" class="st32" inkscape:transform-center-y="-7.1245069" inkscape:transform-center-x="22.076699" inkscape:label="RPE_LOC729020 f" inkscape:connector-curvature="0" id="F_RPE_LOC729020" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 780.2,198.61855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.4,6.6 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z" class="st30" inkscape:label="PRPS2_PRPS1_PRPS1L1 f" inkscape:connector-curvature="0" id="F_PRPS2_PRPS1_PRPS1L1" /><text style="font-size:10px;font-family:Calibri" id="text1328" class="st17 st18" x="928.5589" y="209.07054">4 Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.00309992" d="m 628.9,518.91855 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m -6.4,-11.7 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 12.1,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 14.1,11.6 -72.4,-0.2 m 19.7,-0.3 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.3,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" class="st128" inkscape:label="ACLY" inkscape:connector-curvature="0" id="R_ACLY" /><text style="font-size:10px;font-family:Calibri" id="text1331" class="st17 st18" x="619.48761" y="501.60864">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text1333" class="st17 st18" x="925.4632" y="502.06665">CoA</text> <text style="font-size:10px;font-family:Calibri" id="text1335" class="st17 st18" x="978.2464" y="502.37036">3ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1337" class="st17 st18" x="944.37335" y="502.11053">2 NADP</text> <text style="font-size:10px;font-family:Calibri" id="text1339" class="st17 st18" x="1005.5902" y="502.01004">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text1341" class="st17 st18" x="1022.222" y="502.37036">CO2</text> <text style="font-size:10px;font-family:Calibri" id="text1343" class="st17 st18" x="935.09015" y="537.14966">2 NADPH</text> <path style="fill:none;stroke:#000000;stroke-width:2.00309992" d="m 990.8,518.11855 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 37.1,-11.1 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m -20.9,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m -56.6,11.1 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 5.6,-11.1 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 28.6,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 42.5,11.6 -117.3,-0.2 m 10.7,-0.3 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 4.3,-11 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" class="st128" inkscape:label="MVD" inkscape:connector-curvature="0" id="R_MVD" /><text style="font-size:10px;font-family:Calibri" id="text1346" class="st17 st18" x="916.46899" y="537.34601">2 H</text> <text style="font-size:10px;font-family:Calibri" id="text1348" class="st17 st18" x="975.79724" y="537.38495">3 ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1350" class="st17 st18" x="1083.433" y="539.12915">2 ippPP</text> <text style="font-size:10px;font-family:Calibri" id="text1352" class="st17 st18" x="1092.3324" y="502.40256">2 PPi</text> <path style="fill:none;stroke:#000000;stroke-width:1.96599996" d="m 1113.5,519.01855 -25,-0.5 m 13.7,-0.2 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.2,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" class="st129" inkscape:label="ARID4B_GGPS1_FDPS_FDPSP7_2" inkscape:connector-curvature="0" id="R_ARID4B_GGPS1_FDPS_FDPSP7_2" /><text style="font-size:10px;font-family:Calibri" id="text1355" class="st17 st18" x="1146.4008" y="536.18677">fPP</text> <text style="font-size:10px;font-family:Calibri" id="text1357" class="st17 st18" x="1147.5316" y="500.91135">15 H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1359" class="st17 st26" x="1166.1605" y="502.91135">2</text> <text style="font-size:10px;font-family:Calibri" id="text1361" class="st17 st18" x="1169.2484" y="500.91135">O</text> <text style="font-size:10px;font-family:Calibri" id="text1363" class="st17 st18" x="1244.015" y="500.13596">2 PPi</text> <text style="font-size:10px;font-family:Calibri" id="text1365" class="st17 st18" x="1178.6937" y="500.73166">13 NADP</text> <text style="font-size:10px;font-family:Calibri" id="text1367" class="st17 st18" x="1269.6381" y="499.95636">for</text> <text style="font-size:10px;font-family:Calibri" id="text1369" class="st17 st18" x="1219.3802" y="500.49734">2 CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1371" class="st17 st26" x="1238.5746" y="502.49734">2</text> <text style="font-size:10px;font-family:Calibri" id="text1373" class="st17 st18" x="1162.7885" y="536.02271">13 NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text1375" class="st17 st18" x="1208.9027" y="536.07941">16 H</text> <text style="font-size:10px;font-family:Calibri" id="text1377" class="st17 st18" x="1230.308" y="535.75806">10 O</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1379" class="st17 st26" x="1249.3265" y="537.75806">2</text> <path style="fill:none;stroke:#000000;stroke-width:1.82200003" d="m 861.2,464.41855 c 5.9,-1 4.4,-9.6 4.4,-9.6 m -19,9.5 29.3,0.3 m -15.1,-0.1 c -6,1.2 -5.5,10.5 -5.5,10.5" class="st130" inkscape:label="MCAT_FASN" inkscape:connector-curvature="0" id="R_MCAT_FASN" /><text style="font-size:10px;font-family:Calibri" id="text1382" class="st17 st18" x="1064.4486" y="447.78546">14 H</text> <path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 888.8,422.31855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -27.6,0.3 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 39.9,9.6 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" class="st30" inkscape:label="AcAcACPSynthesis f" inkscape:connector-curvature="0" id="F_AcAcACPSynthesis" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 477.8,777.11855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m 0,-10.5 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m 0,-10.5 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -10.5,38.3 c -2.1,6.9 -2.1,6.9 -2.1,6.9 l -2.3,-6.8 2.2,1.7 2.2,-1.8 z" class="st30" inkscape:label="DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB F" inkscape:connector-curvature="0" id="F_DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB" /><path style="fill:none;stroke:#000000;stroke-width:2.37849998" d="m 443.6,735.91855 -27.4,0 0,127.5 116.3,0 m -60.4,0.2 c 7.3,-1.5 7.3,-12.6 7.3,-12.6 m 17.7,12.5 c -7.6,1.4 -8.5,11 -8.5,11 m -25.1,-11 c -7.6,1.4 -8.5,11 -8.5,11 m -15.9,-11 c -7.6,1.4 -8.5,11 -8.5,11 m 8.7,-11.2 c 7.3,-1.5 7.3,-12.6 7.3,-12.6" class="st131" inkscape:label="PC" inkscape:connector-curvature="0" id="R_PC" /><text style="font-size:10px;font-family:Calibri" id="text1387" class="st17 st18" x="437.9422" y="842.4212">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1389" class="st17 st18" x="475.73709" y="842.85181">Pi</text> <text style="font-size:10px;font-family:Calibri" id="text1391" class="st17 st18" x="420.13361" y="882.27466">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1393" class="st17 st18" x="444.71021" y="881.94067">HCO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1395" class="st17 st26" x="462.80591" y="883.94067">3</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1397" class="st17 st26" x="465.89481" y="876.44067">-</text> <text style="font-size:10px;font-family:Calibri" id="text1399" class="st17 st18" x="485.21021" y="881.94067">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 530.5,861.11855 c 6.9,2.1 6.9,2.1 6.9,2.1 l -6.8,2.3 1.7,-2.2 -1.8,-2.2 z m -86,-10.4 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 33,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st32" inkscape:label="PC f" inkscape:connector-curvature="0" id="F_PC" /><path style="fill:none;stroke:#000000;stroke-width:1.53359997" d="m 562.6,822.11855 c 4.2,1.1 4.2,1.1 4.2,1.1 l -4.4,1.6 1.2,-1.4 -1,-1.3 z m -6.5,-9.6 c 0.1,-5.5 0.1,-5.5 0.1,-5.5 l -3.5,4.6 2.1,-0.8 1.3,1.7 z" class="st132" inkscape:label="CS f" inkscape:connector-curvature="0" id="F_CS" /><text style="font-size:10px;font-family:Calibri" id="text1403" class="st17 st18" x="681.67023" y="783.07056">H</text> <text style="font-size:10px;font-family:Calibri" id="text1405" class="st17 st18" x="683.4339" y="716.35669">H</text> <path style="fill:none;stroke:#000000;stroke-width:1.49890006" d="m 662.8,725.01855 c -1,6.8 -7.1,8.5 -7.1,8.5 m 45.3,-7.2 c -1,6.8 -7.1,8.5 -7.1,8.5 m -8.9,-11 c -1,6.8 -7.1,8.5 -7.1,8.5 m -39,-5.5 c 1,6.8 7.1,8.5 7.1,8.5 m -13.6,3.7 c 26,-9.2 53,-8.9 79.3,1" class="st133" inkscape:label="IDH2" inkscape:connector-curvature="0" id="R_IDH2" /><path style="fill:none;stroke:#000000;stroke-width:1.81630003" d="m 638.9,767.21855 c -3.8,4 -3.8,4 -3.8,4 l 1.6,-6.8 0.4,2.8 1.8,0 z m -5.4,-13.8 c -6.3,-1.4 -6.3,-1.4 -6.3,-1.4 l 4.4,4.1 -0.4,-2 2.3,-0.7 z" class="st134" inkscape:label="IDH3 b" inkscape:connector-curvature="0" id="B_IDH3" /><path style="fill:none;stroke:#000000;stroke-width:1.49890006" d="m 632.4,755.01855 c 26,9.2 53,8.9 79.3,-1 m -74.1,13.2 c 1,-6.8 7.1,-8.5 7.1,-8.5 m 40.3,11 c -1,-6.8 -7.1,-8.5 -7.1,-8.5 m 23.1,6 c -1,-6.8 -7.1,-8.5 -7.1,-8.5 m -29.9,10.7 c -1,-6.8 -7.1,-8.5 -7.1,-8.5" class="st133" inkscape:connector-curvature="0" id="R_IDH3" /><text style="font-size:10px;font-family:Calibri" id="text1410" class="st17 st18" x="789.9563" y="767.94257">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1412" class="st17 st18" x="814.58044" y="767.94257">+</text> <text style="font-size:10px;font-family:Calibri" id="text1414" class="st17 st18" x="789.9563" y="780.44257">H</text> <text style="font-size:10px;font-family:Calibri" id="text1416" class="st17 st18" x="796.18683" y="780.44257">+</text> <text style="font-size:10px;font-family:Calibri" id="text1418" class="st17 st18" x="801.1673" y="780.44257">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1420" class="st17 st26" x="813.03253" y="782.44257">2</text> <text style="font-size:10px;font-family:Calibri" id="text1422" class="st17 st18" x="509.7952" y="894.0257">NADH+H</text> <text style="font-size:10px;font-family:Calibri" id="text1424" class="st17 st18" x="489.20441" y="902.28931">NAD</text> <path style="fill:none;stroke:#000000;stroke-width:2.09549999" d="m 429.3,916.81855 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 29.9,10.9 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 32.8,10.9 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 22.9,10.8 c 7.3,-1.3 7.3,-10.9 7.3,-10.9 m 76.2,10.9 -167.7,0 0,-187.3 34.9,0" class="st135" inkscape:label="ME2_ME3_1" inkscape:connector-curvature="0" id="R_ME2_ME3_1" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 424,906.71855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 22.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 25.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -31,-176.2 c 6.4,-2 6.4,-2 6.4,-2 l -6.6,-2.3 1.7,2.2 -1.5,2.1 z" class="st30" inkscape:label="ME2_ME3_1 f" inkscape:connector-curvature="0" id="F_ME2_ME3_1" /><text style="font-size:10px;font-family:Calibri" id="text1428" class="st17 st18" x="457.70239" y="898.8313">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1430" class="st17 st18" x="441.25998" y="898.8313">H</text> <text style="font-size:10px;font-family:Calibri" id="text1432" class="st17 st18" x="415.7493" y="898.8147">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1434" class="st17 st26" x="427.6145" y="900.8147">2</text> <text style="font-size:10px;font-family:Calibri" id="text1436" class="st17 st18" x="503.78641" y="944.25116">NADP</text> <path style="fill:none;stroke:#000000;stroke-width:2.14289999" d="m 429.3,920.51855 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 29.9,-11.4 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 32.8,-11.4 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 38.1,-11.3 c 7.2,1.7 7.2,14.6 7.2,14.6 m 61.2,-14.6 -177,0 0,-199.5 42.5,0" class="st136" inkscape:label="ME2_ME3_2" inkscape:connector-curvature="0" id="R_ME2_ME3_2" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 424,930.01855 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 22.5,0 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 25.5,0 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m -31,-207 c 6.5,-1.8 6.5,-1.8 6.5,-1.8 l -6.5,-2.5 1.7,2.2 -1.7,2.1 z" class="st30" inkscape:label="ME2_ME3_2 f" inkscape:connector-curvature="0" id="F_ME2_ME3_2" /><text style="font-size:10px;font-family:Calibri" id="text1440" class="st17 st18" x="456.02231" y="944.76099">NADPH</text> <text style="font-size:10px;font-family:Calibri" id="text1442" class="st17 st18" x="440.8992" y="944.5813">H</text> <text style="font-size:10px;font-family:Calibri" id="text1444" class="st17 st18" x="415.7981" y="944.5813">CO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1446" class="st17 st26" x="427.66339" y="946.5813">2</text> <path style="fill:none;stroke:#000000;stroke-width:2.10339999" d="m 615.9,579.61855 c 5.9,-1.5 5.4,-12.9 5.4,-12.9 m 15.5,12.5 c 5.9,-1.3 4.4,-12.5 4.4,-12.5 m 14,12.5 -72.4,-0.2 m 19.7,-0.3 c -5.9,1.4 -4.4,13.7 -4.4,13.7 m 1.3,-12.8 c 5.9,-1.5 5.4,-12.9 5.4,-12.9" class="st137" inkscape:label="IDH1" inkscape:connector-curvature="0" id="R_IDH1" /><text style="font-size:10px;font-family:Calibri" id="text1449" class="st17 st18" x="619.24744" y="558.70239">H</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 327.8,483.61855 c 0,-27.3 0,-27.3 0,-27.3 m -0.4,15.6 c -1.1,-6 -11.6,-4.8 -11.6,-4.8" class="st14" inkscape:label="FH_2" inkscape:connector-curvature="0" id="R_FH_2" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 330.1,482.71855 c -2.2,7.3 -2.2,7.3 -2.2,7.3 l -2.2,-7.3 2.2,1.8 2.2,-1.8 z" class="st14" inkscape:label="FH_2 f" inkscape:connector-curvature="0" id="F_FH_2" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 329.9,456.91855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2.2,7.3 2.2,-1.8 2.2,1.8 z m -14.7,12 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" class="st14" inkscape:label="FH_2 b" inkscape:connector-curvature="0" id="B_FH_2" /><text style="font-size:10px;font-family:Calibri" id="text1454" class="st17 st18" x="287.3587" y="527.83325">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text1456" class="st17 st18" x="271.14529" y="544.677">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1458" class="st17 st18" x="295.76929" y="544.677">+</text> <text style="font-size:10px;font-family:Calibri" id="text1460" class="st17 st18" x="300.74979" y="544.677">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1462" class="st15 st16" x="429.36963" y="1131.9838">Q</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1464" class="st15 st16" x="350.36279" y="1132.7025">NADH</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1466" class="st15 st16" x="457.80908" y="1199.7504">4 H</text> <path style="fill:none;stroke:#000000;stroke-width:2.06859994" d="m 474.1998,1181.2711 -2.8,5.9 -2,-6.1 2.3,1.6 2.5,-1.4 z m 12.4,-39.3 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m 29.4,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" class="st138" inkscape:label="Complex1ROS f" inkscape:connector-curvature="0" id="F_Complex1ROS" /><path style="fill:none;stroke:#000000;stroke-width:2.06859994" d="m 761.84776,1178.6878 -2.8,5.9 -2,-6.1 2.3,1.6 z m 27.25948,-37.9976 -2.8,-5.9 -2,6.1 2.3,-1.6 z m 52.82373,-0.1976 -2.8,-5.9 -2,6.1 2.3,-1.6 z" class="st138" inkscape:label="Complex3 f" inkscape:connector-curvature="0" id="F_Complex3" sodipodi:nodetypes="ccccccccccccccc" /><path style="fill:none;stroke:#000000;stroke-width:2.06859994" d="m 1050.1,1177.9186 -2.8,5.9 -2,-6.1 2.3,1.6 2.5,-1.4 z m 96.4,-35.6 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m -72,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" class="st138" inkscape:label="Complex4 f" inkscape:connector-curvature="0" id="F_Complex4" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1471" class="st15 st16" x="1186.5951" y="1132.6877">ADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1473" class="st15 st16" x="1258.2738" y="1131.0793">ATP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1475" class="st15 st16" x="1288.1302" y="1131.2004">2 H</text> <text style="font-size:9.75px;font-family:Calibri-Bold" id="text1477" class="st15 st40" x="1309.9506" y="1134.3997">2</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1479" class="st15 st16" x="1314.8929" y="1131.2004">O</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1481" class="st15 st16" x="1224.5297" y="1132.1653">Pi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1483" class="st15 st16" x="1234.349" y="1192.5237">4 H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1485" class="st15 st16" x="1337.7094" y="1131.2004">4 H</text> <path style="fill:none;stroke:#000000;stroke-width:1.11870003" d="m 1310.4,1155.6186 0,-13.8 m -106.2,-2 0,16.2 142.6,0 0,-16.2 m -116.3,-0.5 0,16.2 m 43.9,0.1 0,-13.8 m -29.7,13.8 0,25.4" class="st139" inkscape:label="ATPsynthase " inkscape:connector-curvature="0" id="R_ATPsynthase" /><path style="fill:none;stroke:#000000;stroke-width:2.06859994" d="m 1313.3,1141.9186 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m 36,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m -72,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" class="st138" inkscape:label="ATPsynthase f" inkscape:connector-curvature="0" id="F_ATPsynthase" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1495" class="st15 st16" x="177.9417" y="839.77655">AKG</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1497" class="st15 st16" x="286.39868" y="840.57635">AKG</text> <path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 275.8,835.31855 -60.2,-0.3 m 44.6,0.3 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -26.7,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7" class="st45" inkscape:label="SLC25A11" inkscape:connector-curvature="0" id="R_SLC25A11" /><path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 267.4,821.81855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 l 0,0 z" class="st140" inkscape:label="SLC25A11 b" inkscape:connector-curvature="0" id="B_SLC25A11" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1501" class="st15 st38" x="258.91681" y="813.65851">Mal</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1503" class="st15 st38" x="218.61449" y="814.12427">Mal</text> <path style="fill:none;stroke:#000000;stroke-width:2.35560012" d="m 233.9,824.21855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 40.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st46" inkscape:label="SLC25A11 f" inkscape:connector-curvature="0" id="F_SLC25A11" /><text style="font-size:10px;font-family:Calibri" id="text1506" class="st17 st18" x="1286.9183" y="796.95239">HCO</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1508" class="st17 st26" x="1305.014" y="798.95239">3</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1510" class="st17 st26" x="1308.1029" y="791.45239">-</text> <text style="font-size:10px;font-family:Calibri" id="text1512" class="st17 st18" x="1261.7601" y="797.07349">2 ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1514" class="st17 st18" x="1312.8011" y="797.28931">H</text> <text style="font-size:10px;font-family:Calibri" id="text1516" class="st17 st18" x="1215.6556" y="796.61255">2 ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1518" class="st17 st18" x="1247.1156" y="797.24536">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1198.1,755.61855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -6.3,-8.1 c -1.9,-7.4 -1.9,-7.4 -1.9,-7.4 l -2.4,7.2 2.2,-1.8 2.1,2 z" class="st73" inkscape:label="OTC_LEFTY1 f" inkscape:connector-curvature="0" id="F_OTC_LEFTY1" /><text style="font-size:10px;font-family:Calibri" id="text1521" class="st17 st18" x="1207.1527" y="756.75415">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1205.4,705.01855 c 5.4,1.6 5.4,1.6 5.4,1.6 l -5.8,1.7 1.6,-1.6 -1.2,-1.7 z m 0,-12 c 5.4,1.6 5.4,1.6 5.4,1.6 l -5.8,1.7 1.6,-1.6 -1.2,-1.7 z m -12.9,-39.4 c -2.6,-7.2 -2.6,-7.2 -2.6,-7.2 l -1.7,7.4 2,-2 2.3,1.8 z" class="st73" inkscape:label="SLC25A15_SLC25A2_1 f" inkscape:connector-curvature="0" id="F_SLC25A15_SLC25A2_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1165.5,612.21855 c -6.9,1.7 -6.9,1.7 -6.9,1.7 l 7,1.5 -1.8,-1.6 1.7,-1.6 z m 14.8,-3.2 c -0.8,-7.6 -0.8,-7.6 -0.8,-7.6 l -3.4,6.8 2.5,-1.4 1.7,2.2 z" class="st73" inkscape:label="ASS1 f" inkscape:connector-curvature="0" id="F_ASS1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1260.6,601.11855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -14.1,15.4 c 0.8,7.6 0.8,7.6 0.8,7.6 l 3.4,-6.8 -2.4,1.4 -1.8,-2.2 z" class="st73" inkscape:label="ARG2_ARG1 f" inkscape:connector-curvature="0" id="F_ARG2_ARG1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1307.9,604.11855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -8.3,-7.4 c -1.9,-7.4 -1.9,-7.4 -1.9,-7.4 l -2.4,7.2 2.2,-1.8 2.1,2 z" class="st73" inkscape:label="OGDH_ODC1_OGDHL f" inkscape:connector-curvature="0" id="F_OGDH_ODC1_OGDHL" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1410.9,573.21855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 19,-6.5 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z" class="st73" inkscape:label="arginineAmidinohydrolase" inkscape:connector-curvature="0" id="F_arginineAmidinohydrolase" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1226.5,773.71855 -7.3,2.2 7.3,2.2 -1.8,-2.2 1.8,-2.2 z m 6.9,9 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 15.5,0.5 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z" class="st73" inkscape:label="CPS1" inkscape:connector-curvature="0" id="F_CPS1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1424.1,609.91855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 7.6,-4.7 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z" class="st73" inkscape:label="PYCRL_PYCR2_PYCR1_LEFTY1_1 f" inkscape:connector-curvature="0" id="F_PYCRL_PYCR2_PYCR1_LEFTY1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1427.1,638.71855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 25.3,-21.9 c -1.8,-7.4 -1.8,-7.4 -1.8,-7.4 l -2.5,7.2 2.2,-1.7 2.1,1.9 z" class="st73" inkscape:label="PYCRL_PYCR2_PYCR1_LEFTY1_2 f" inkscape:connector-curvature="0" id="F_PYCRL_PYCR2_PYCR1_LEFTY1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 389.7,362.01855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:connector-curvature="0" id="path2280" /><path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 376.4,277.61855 c 1.4,5.3 17.3,5.1 17.3,5.1 m -78.9,-8.4 c 36.8,-1.5 60.9,1.7 60.9,1.7 m 0.6,47.2 -0.1,-55.9 m -15.7,21.2 c 9.7,-2.9 16,3.2 16,3.2" class="st79" inkscape:connector-curvature="0" id="R_SHMT1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 314.9,275.71855 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z m 63.2,-8.2 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -14.8,22 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:connector-curvature="0" id="F_SHMT1" /><text style="font-size:9.99962234px;font-family:Calibri" id="text1534" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="333.75421" y="294.88434">H</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text1536" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="339.98471" y="296.88437">2</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1538" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="343.07361" y="294.8844">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 401.7,328.31855 c 1.3,-7 1.3,-7 1.3,-7 l 1.9,6.9 -1.7,-1.7 -1.5,1.8 z m 10.4,8.6 c 6.3,2.2 6.3,2.2 6.3,2.2 l -6.5,1.7 1.7,-1.9 -1.5,-2 z" class="st73" inkscape:label="SDS_SDSL_SRR" inkscape:connector-curvature="0" id="F_SDS_SDSL_SRR" /><path style="fill:none;stroke:#000000;stroke-width:2.18140006" d="m 453.8,622.71855 0,19.5 -67.5,0 m 23.1,-11 c -2.7,7 3.5,11.5 3.5,11.5 m 10.9,-0.1 c 5.4,-0.9 4.9,-10.3 4.9,-10.3" class="st141" inkscape:label="NIT2" inkscape:connector-curvature="0" id="R_NIT2" /><text style="font-size:10px;font-family:Calibri" id="text1542" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="301.05325" y="582.61121">Glu</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1544" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="288.98755" y="601.8775">AKG</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 327.2,600.61855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m -7,-4.3 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:label="GOT1_GOT2_GOT1L1_2 bb" inkscape:connector-curvature="0" id="B_GOT1_GOT2_GOT1L1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.06480002" d="m 329.3,603.91855 -0.2,-29.4 m -12.3,8.1 c 7.6,-2.9 12.6,3.3 12.6,3.3 m 0,3.4 c -0.9,5.5 -11.2,5.2 -11.2,5.2" class="st142" inkscape:label="GOT1_GOT2_GOT1L1_2" inkscape:connector-curvature="0" id="R_GOT1_GOT2_GOT1L1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 331,575.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -10.2,7.7 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:label="GOT1_GOT2_GOT1L1_2 f" inkscape:connector-curvature="0" id="F_GOT1_GOT2_GOT1L1_2" /><text style="font-size:10px;font-family:Calibri" id="text1549" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="302.24371" y="760.4939">Glu</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1551" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="288.6842" y="751.92932">AKG</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 328.8,764.61855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m -8,-4.3 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:label="GOT2_GOT1L1_1 b" inkscape:connector-curvature="0" id="B_GOT2_GOT1L1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.06480002" d="m 330.9,768.01855 -0.2,-29.4 m -13.3,8.1 c 8.1,-2.9 13.4,3.3 13.4,3.3 m -0.1,3.3 c -1,5.4 -11.9,5.2 -11.9,5.2" class="st142" inkscape:label="GOT2_GOT1L1_1" inkscape:connector-curvature="0" id="R_GOT2_GOT1L1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 332.6,739.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -11.2,7.7 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" class="st73" inkscape:label="GOT2_GOT1L1_1 f" inkscape:connector-curvature="0" id="F_GOT2_GOT1L1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.5236001" d="m 270.8,636.91855 c -1.4,6.1 -13.6,4.6 -13.6,4.6 m 58.1,-13.7 -44.2,0 0,24.1" class="st143" inkscape:label="FH_3" inkscape:connector-curvature="0" id="R_FH_3" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 203.3,605.11855 c -1.5,-5.1 -1.5,-5.1 -1.5,-5.1 l -1.8,5.5 1.7,-1.5 1.6,1.1 z m -25.5,6.7 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" class="st30" inkscape:connector-curvature="0" id="F_ASNS" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 306.6,623.91855 c 6.3,-2.2 6.3,-2.2 6.3,-2.2 l -6.5,-1.7 1.7,1.9 -1.5,2 z m -87.9,7 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st30" inkscape:connector-curvature="0" id="path2462" /><path style="fill:none;stroke:#000000;stroke-width:2.5697" d="m 174.6,621.51855 134,0.1 m -89.1,9.8 c 2.6,-5.3 -3.5,-9.1 -3.5,-9.1 m -23.9,-0.1 c -5,1.5 -4.6,13.1 -4.6,13.1" class="st144" inkscape:connector-curvature="0" id="R_ASRGL1_ASPG" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 327.8,536.41855 c -1.1,6 -11.6,4.8 -11.6,4.8 m 11.6,5.6 c 0,-30.5 0,-30.5 0,-30.5 m 0,14.1 c -1.1,-6 -11.6,-4.8 -11.6,-4.8" class="st14" inkscape:label="MDH1_MDH1B " inkscape:connector-curvature="0" id="R_MDH1_MDH1B" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 315.6,539.51855 c -4.9,2 -4.9,2 -4.9,2 l 5.6,1.3 -1.7,-1.6 1,-1.7 z m 14.6,6.2 c -2.2,7.3 -2.2,7.3 -2.2,7.3 l -2.2,-7.3 2.2,1.8 2.2,-1.8 z" class="st14" inkscape:label="MDH1_MDH1B f" inkscape:connector-curvature="0" id="F_MDH1_MDH1B" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 329.9,517.91855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2.2,7.3 2.2,-1.8 2.2,1.8 z m -14.3,9.5 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" class="st14" inkscape:label="MDH1_MDH1B b" inkscape:connector-curvature="0" id="B_MDH1_MDH1B" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 853.3,730.91855 c 1.7,-6.9 1.7,-6.9 1.7,-6.9 l 1.5,7 -1.6,-1.7 -1.6,1.6 z m -94.9,7.7 c -7.3,2.3 -7.3,2.3 -7.3,2.3 l 7.3,2 -1.9,-2.1 1.9,-2.2 z" class="st73" inkscape:label="GLUD1_GLUD2_1 F" inkscape:connector-curvature="0" id="F_GLUD1_GLUD2_1" /><text style="font-size:10px;font-family:Calibri" id="text1564" class="st17 st18" x="843.83331" y="243.37524">Asp</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1566" class="st15 st16" x="1104.5219" y="229.47775">AMP</text> <text style="font-size:10px;font-family:Calibri" id="text1568" class="st17 st18" x="1032.9047" y="239.12524">GTP</text> <text style="font-size:10px;font-family:Calibri" id="text1570" class="st17 st18" x="1056.3265" y="238.95825">Asp</text> <text style="font-size:10px;font-family:Calibri" id="text1572" class="st17 st18" x="1070.4886" y="207.11935">Fum</text> <text style="font-size:10px;font-family:Calibri" id="text1574" class="st17 st18" x="1038.6117" y="207.13495">GDP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1576" class="st15 st16" x="1190.1205" y="274.58914">GMP</text> <text style="font-size:10px;font-family:Calibri" id="text1578" class="st17 st18" x="1022.7562" y="251.87625">NAD</text> <text style="font-size:10px;font-family:Calibri" id="text1580" class="st17 st18" x="1044.2269" y="251.96504">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1582" class="st17 st26" x="1050.4574" y="253.96504">2</text> <text style="font-size:10px;font-family:Calibri" id="text1584" class="st17 st18" x="1053.5463" y="251.96504">O</text> <text style="font-size:10px;font-family:Calibri" id="text1586" class="st17 st18" x="1096.4867" y="251.55885">NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1588" class="st17 st18" x="1124.9867" y="251.55885">H</text> <text style="font-size:10px;font-family:Calibri" id="text1590" class="st17 st18" x="1136.9867" y="251.55885">AMP</text> <text style="font-size:10px;font-family:Calibri" id="text1592" class="st17 st18" x="1062.2269" y="251.96504">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1594" class="st17 st18" x="1078.7269" y="251.96504">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1596" class="st17 st26" x="1091.4125" y="253.96504">3</text> <path style="fill:#786721;stroke:#000000;stroke-width:2.5" d="m 1165.6,258.31855 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m 7.2,8.5 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -25.2,-8.5 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m -16.5,0 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m -21,0 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z" class="st145" inkscape:label="GMPS f" inkscape:connector-curvature="0" id="F_GMPS" /><text style="font-size:10px;font-family:Calibri" id="text1599" class="st17 st18" x="1159.4867" y="251.55885">PPi</text> <path style="fill:none;stroke:#000000;stroke-width:1.45089996" d="m 1017,234.51855 0,30 156.7,0 m -13.1,-0.1 c 4.8,-1 3,-7.4 3,-7.4 m -76.3,-1.9 c -1.5,6.1 4.8,9.3 4.8,9.3 m -24.3,-9.3 c -1.5,6.1 4.8,9.3 4.8,9.3 m 70,0 c 4.8,-1 3,-7.4 3,-7.4 m -19.5,7.4 c 4.8,-1 3,-7.4 3,-7.4 m -79.3,-1.9 c -1.5,6.1 4.8,9.3 4.8,9.3 m -19.7,-9.3 c -1.5,6.1 4.8,9.3 4.8,9.3 m 65.4,0 c 4.8,-1 3,-7.4 3,-7.4" class="st146" inkscape:label="GMPS" inkscape:connector-curvature="0" id="R_GMPS" /><text style="font-size:10px;font-family:Calibri" id="text1602" class="st17 st18" x="1089.4623" y="295.44165">NADPH</text> <path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1126.6,282.21855 c -1.6,4.7 -1.6,4.7 -1.6,4.7 l -2.4,-4.6 2.1,1.1 1.9,-1.2 z m -18,0 c -1.6,4.7 -1.6,4.7 -1.6,4.7 l -2.4,-4.6 2.1,1.1 1.9,-1.2 z m 64,-4.2 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.3,-1.9 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:connector-curvature="0" id="path2738" /><text style="font-size:10px;font-family:Calibri" id="text1605" class="st17 st18" x="1122.9066" y="295.62234">H</text> <text style="font-size:10px;font-family:Calibri" id="text1607" class="st17 st18" x="1045.0922" y="295.91525">NADP</text> <text style="font-size:10px;font-family:Calibri" id="text1609" class="st17 st18" x="1070.9701" y="295.55396">NH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1611" class="st17 st26" x="1083.6556" y="297.55396">3</text> <path style="fill:none;stroke:#000000;stroke-width:1.7529" d="m 1076.8,287.31855 c -1.5,-7.6 4.8,-11.6 4.8,-11.6 m -24.2,11.6 c -1.5,-7.6 4.8,-11.6 4.8,-11.6 m 59.4,0.1 c 4.8,0.9 3,6.9 3,6.9 m -21,-6.9 c 4.8,0.9 3,6.9 3,6.9 m -95.6,-48.5 0,41.6 162.2,0" class="st147" inkscape:label="GMPR2_GMPR" inkscape:connector-curvature="0" id="R_GMPR2_GMPR" /><path style="fill:none;stroke:#000000;stroke-width:1.92519999" d="m 1257.8,269.81855 c -24.9,0 -24.9,0 -24.9,0 m 16.5,9.6 c 2.4,-5.9 -3.6,-9.5 -3.6,-9.5 m -2.6,0.1 c -5,0.9 -4.4,9.3 -4.4,9.3" class="st148" inkscape:label="GUK1_1" inkscape:connector-curvature="0" id="R_GUK1_1" /><text style="font-size:10px;font-family:Calibri" id="text1615" class="st17 st18" x="1305.1234" y="296.55396">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1617" class="st17 st26" x="1311.3539" y="298.55396">2</text> <text style="font-size:10px;font-family:Calibri" id="text1619" class="st17 st18" x="1314.4427" y="296.55396">O</text> <path style="fill:none;stroke:#000000;stroke-width:1.89830005" d="m 1324,269.41855 c -24.2,0 -24.2,0 -24.2,0 m 15.6,11.1 c 2.4,-6.8 -3.6,-11 -3.6,-11" class="st149" inkscape:label="RRM2B_TXN_RRM1_RRM2B_1" inkscape:connector-curvature="0" id="R_RRM2B_TXN_RRM1_RRM2B_1" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1622" class="st15 st16" x="1336.0267" y="274.81174">dGDP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1624" class="st15 st16" x="1189.1234" y="226.54515">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1626" class="st17 st18" x="1144.3539" y="205.21504">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1628" class="st17 st18" x="1162.7318" y="204.82245">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1630" class="st17 st18" x="1225.3851" y="248.99045">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1632" class="st17 st26" x="1231.6156" y="250.99045">2</text> <text style="font-size:10px;font-family:Calibri" id="text1634" class="st17 st18" x="1234.7035" y="248.99045">O</text> <path style="fill:none;stroke:#000000;stroke-width:1.77349997" d="m 1239.9,223.41855 c -21.1,0 -21.1,0 -21.1,0 m 12.6,11.4 c 2.4,-7 -3.6,-11.3 -3.6,-11.3" class="st150" inkscape:label="RRM2B_TXN_RRM1_RRM2B_2" inkscape:connector-curvature="0" id="R_RRM2B_TXN_RRM1_RRM2B_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1637" class="st15 st16" x="1251.2035" y="225.97145">dADP</text> <text style="font-size:10px;font-family:Calibri" id="text1639" class="st17 st18" x="989.38702" y="354.02756">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1641" class="st17 st18" x="1006.057" y="353.84204">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 1014.9,334.41855 c 7.4,-1.9 7.4,-1.9 7.4,-1.9 l -7.2,-2.4 1.8,2.2 -2,2.1 z m -5.5,5.8 c 2.4,5.1 2.4,5.1 2.4,5.1 l 2,-5.2 -2.1,1.3 -2.3,-1.2 z" class="st109" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3 b" inkscape:connector-curvature="0" id="B_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><path style="fill:none;stroke:#000000;stroke-width:1.55369997" d="m 1004.5,332.21855 c -4.9,1.2 -3.1,9.2 -3.1,9.2 m 10.5,0.8 c 1.6,-6.3 -4.9,-9.6 -4.9,-9.6 m 10.9,-0.3 -25.4,-0.2" class="st151" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" inkscape:connector-curvature="0" id="R_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><text style="font-size:10px;font-family:Calibri" id="text1645" class="st17 st18" x="484.89191" y="128.75026">ADP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1647" class="st15 st16" x="448.1004" y="156.49535">G6P</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1649" class="st15 st16" x="450.83908" y="90.690155">Glc</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 465.3,424.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 11.2,-16.2 c 1.6,0.7 3.3,1.4 4.9,2 -1.9,0.4 -3.8,0.8 -5.6,1.3 0.6,-0.5 1.1,-1 1.7,-1.6 -0.4,-0.5 -0.7,-1.1 -1,-1.7 l 0,0 z" class="st14" inkscape:label="CRISP3_PGK1_MIA3_PGK2 f" inkscape:connector-curvature="0" id="F_CRISP3_PGK1_MIA3_PGK2" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 447.4,607.61855 7.3,2.2 -7.3,2.2 1.8,-2.2 -1.8,-2.2 z m -10.6,-6.6 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st30" inkscape:label="LDH b" inkscape:connector-curvature="0" id="B_LDH" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 861.8,126.21855 0,-11.3 30,0 m -20.8,-8.8 c -1.7,5.6 4.7,8.7 4.7,8.7 m 3.2,-0.2 c 4.9,-1.1 3.2,-8.9 3.2,-8.9" class="st109" inkscape:label="PFKP_PFKL_PFKM_3" inkscape:connector-curvature="0" id="R_PFKP_PFKL_PFKM_3" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 888.2,116.91855 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z m -6.9,-9.3 c 1.5,-4.3 1.5,-4.3 1.5,-4.3 l 1.4,4.7 -1.4,-1.3 -1.5,0.9 z" class="st30" inkscape:label="PFKP_PFKL_PFKM_3 b" inkscape:connector-curvature="0" id="B_PFKP_PFKL_PFKM_3" /><path style="fill:none;stroke:#000000;stroke-width:1.71169996" d="m 859.5,122.51855 c 2.1,6.2 2.1,6.2 2.1,6.2 l 2.1,-6.2 -2.1,1.5 -2.1,-1.5 z m 9.8,-14.9 c 1.5,-4.3 1.5,-4.3 1.5,-4.3 l 1.4,4.7 -1.4,-1.3 -1.5,0.9 z" class="st152" inkscape:label="PFKP_PFKL_PFKM_3 f" inkscape:connector-curvature="0" id="F_PFKP_PFKL_PFKM_3" /><path style="fill:none;stroke:#000000;stroke-width:1.74290001" d="m 491.3,814.71855 61.5,3.7 m 11.8,25.5 c -4.4,0.5 -8.8,-1.3 -11.3,-4.5 -2.5,-3.3 -2.7,-7.5 -0.6,-10.8 2.2,-3.4 6.4,-5.3 10.8,-5.1 m -9.8,29.2 c -3.7,-13.4 -3.5,-27.4 0.7,-40.9" class="st153" inkscape:label="CS" inkscape:connector-curvature="0" id="R_CS" /><path style="fill:none;stroke:#000000;stroke-width:1.63900006" d="m 662.5,768.41855 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z m 37.5,-1.5 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z m 9.6,-14.8 c 6.3,-1.4 6.3,-1.4 6.3,-1.4 l -4.4,4.1 0.4,-2 -2.3,-0.7 z m -26.1,17.8 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z" class="st154" inkscape:label="IDH3 f" inkscape:connector-curvature="0" id="F_IDH3" /><path style="fill:none;stroke:#000000;stroke-width:1.81630003" d="m 640,727.51855 c -3.8,-4 -3.8,-4 -3.8,-4 l 1.6,6.8 0.4,-2.8 1.8,0 z m -6.5,12.6 c -6.3,1.4 -6.3,1.4 -6.3,1.4 l 4.4,-4.1 -0.4,2 2.3,0.7 z" class="st134" inkscape:label="IDH2 b" inkscape:connector-curvature="0" id="B_IDH2" /><path style="fill:none;stroke:#000000;stroke-width:1.63900006" d="m 661.1,725.61855 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m 38.1,1.5 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m -15.7,-3 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m 26.1,17.3 c 6.3,1.4 6.3,1.4 6.3,1.4 l -4.4,-4.1 0.4,2 -2.3,0.7 z" class="st154" inkscape:connector-curvature="0" id="path2385" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 775.5,787.91855 c 4.5,4.3 4.5,4.3 4.5,4.3 l -1.5,-6.1 -0.8,2.2 -2.2,-0.4 z m 7.8,-13.5 c 3.8,-1 3.8,-1 3.8,-1 l -2.8,3.2 0.3,-1.7 -1.3,-0.5 z" class="st55" inkscape:label="DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL f" inkscape:connector-curvature="0" id="F_DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" /><path style="fill:none;stroke:#000000;stroke-width:1.81599998" d="m 551.9,886.51855 c -4,4 -4,4 -4,4 l 5.5,-0.9 -1.9,-1 0.4,-2.1 z m 9.4,-8.4 c -4.3,-4.3 -4.3,-4.3 -4.3,-4.3 l 1.3,6 0.8,-2.1 2.2,0.4 z" class="st55" inkscape:label="MDH2 f" inkscape:connector-curvature="0" id="F_MDH2" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 572.4,693.91855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -10.5,-159.2 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" class="st30" inkscape:label="SLC25A1 f" inkscape:connector-curvature="0" id="F_SLC25A1" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 561.5,781.41855 c -2.3,6.3 -2.3,6.3 -2.3,6.3 l -1.6,-6.5 1.9,1.7 2,-1.5 z m -16.4,-117.8 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" class="st73" inkscape:label="SLC25A1 b" inkscape:connector-curvature="0" id="B_SLC25A1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 639.9,566.81855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.1,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -16.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 50.9,14.5 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:label="IDH1 f" inkscape:connector-curvature="0" id="F_IDH1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 637.5,509.41855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -16.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.1,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 51.9,11.5 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:label="ACLY f" inkscape:connector-curvature="0" id="F_ACLY" /><path style="fill:none;stroke:#000000;stroke-width:2.41549993" d="m 1094.7,430.01855 -120.1,-0.2 m 106.7,0.4 c -6,1.3 -5.5,10.6 -5.5,10.6 m -88,-10.9 c -6,1.3 -5.5,10.6 -5.5,10.6 m 48,-10.5 c -6,1.3 -5.5,10.6 -5.5,10.6 m 3.2,-10.2 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m 46.7,11.9 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m -93.9,11.4 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m 58.8,11.9 c 5.9,-1.3 4.4,-11.9 4.4,-11.9" class="st155" inkscape:label="OLAH_FASN " inkscape:connector-curvature="0" id="R_OLAH_FASN" /><text style="font-size:10px;font-family:Calibri" id="text1667" class="st17 st18" x="722.22681" y="501.87915">CoA</text> <path style="fill:none;stroke:#000000;stroke-width:1.96720004" d="m 740.8,519.01855 -25,-0.5 m 12.1,-0.2 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.3,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" class="st156" inkscape:label="ACAT1_ACAT2" inkscape:connector-curvature="0" id="R_ACAT1_ACAT2" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 728.4,509.41855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 11.1,11.6 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z" class="st30" inkscape:label="ACAT1_ACAT2 f" inkscape:connector-curvature="0" id="F_ACAT1_ACAT2" /><text style="font-size:10px;font-family:Calibri" id="text1671" class="st17 st18" x="710.4895" y="542.85089">AcCoA</text> <path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 716.3,520.51855 c -6.4,-2.1 -6.4,-2.1 -6.4,-2.1 l 6.5,-1.8 -1.7,1.9 1.6,2 z m 5.8,7.9 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st157" inkscape:label="ACAT1_ACAT2 B" inkscape:connector-curvature="0" id="B_ACAT1_ACAT2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1674" class="st15 st16" x="749.35974" y="522.77277">AcAcCoA</text> <path style="fill:none;stroke:#000000;stroke-width:1.83369994" d="m 841.4,518.71855 c -5.9,1 -4.4,9.5 -4.4,9.5 m -18.1,-9.5 c -5.9,1 -4.4,9.5 -4.4,9.5 m 7.6,-9.6 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 21.3,11.7 -37.5,-0.4" class="st158" inkscape:label="HMGCS1_HMGCS2 " inkscape:connector-curvature="0" id="R_HMGCS1_HMGCS2" /><text style="font-size:10px;font-family:Calibri" id="text1677" class="st17 st18" x="828.9563" y="536.06281">H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1679" class="st17 st26" x="835.18683" y="538.06281">2</text> <text style="font-size:10px;font-family:Calibri" id="text1681" class="st17 st18" x="838.2757" y="536.06281">O</text> <text style="font-size:10px;font-family:Calibri" id="text1683" class="st17 st18" x="798.9895" y="535.35089">AcCoA</text> <text style="font-size:10px;font-family:Calibri" id="text1685" class="st17 st18" x="818.22681" y="501.87915">CoA</text> <path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 846,521.01855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -21,-11.6 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st157" inkscape:label="HMGCS1_HMGCS2 f" inkscape:connector-curvature="0" id="F_HMGCS1_HMGCS2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1688" class="st15 st16" x="855.85974" y="522.77277">HMGCoA</text> <path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 1035.4,520.81855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -102.4,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 25.9,0.4 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 33,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 18,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 16.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st157" inkscape:label="MVD f" inkscape:connector-curvature="0" id="F_MVD" /><path style="fill:none;stroke:#000000;stroke-width:1.85309994" d="m 1269.2,518.61855 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -24.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -27.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -51.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m 57.3,10.3 c -5.9,1 -4.4,9.6 -4.4,9.6 m -15.8,-9.6 c -5.9,1 -4.4,9.6 -4.4,9.6 m -36.9,-10.1 c -5.9,1 -4.4,9.6 -4.4,9.6 m 105.2,-9.1 -133.5,-0.2 m 9.1,-0.1 c -5.9,1 -4.4,9.6 -4.4,9.6 m 4.3,-9.5 c 5.9,-1.2 5.4,-10.1 5.4,-10.1" class="st159" inkscape:label="DHCR24_LEFTY1" inkscape:connector-curvature="0" id="R_DHCR24_LEFTY1" /><path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 1113.4,520.51855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -11.1,-10.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st157" inkscape:label="ARID4B_GGPS1_FDPS_FDPSP7_2 f" inkscape:connector-curvature="0" id="F_ARID4B_GGPS1_FDPS_FDPSP7_2" /><path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 1281,520.71855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -7.8,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -19.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -46.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st157" inkscape:label="DHCR24_LEFTY1 f" inkscape:connector-curvature="0" id="F_DHCR24_LEFTY1" /><path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 768.2,457.11855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -35,0.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 45.6,8.8 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" class="st157" inkscape:label="ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2 f" inkscape:connector-curvature="0" id="F_ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" /><path style="fill:none;stroke:#000000;stroke-width:2.22309995" d="m 779,432.11855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -16,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st157" inkscape:label="FASN_1 f" inkscape:connector-curvature="0" id="F_FASN_1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 864.2,457.11855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 11.6,9.6 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" class="st22" inkscape:connector-curvature="0" id="F_MCAT_FASN" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1093.3,432.21855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -11.1,-11.5 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -51.2,-1.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 25,0.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -63.6,1.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st22" inkscape:label="OLAH_FASN f" inkscape:connector-curvature="0" id="F_OLAH_FASN" /><path style="fill:none;stroke:#000000;stroke-width:2.2256" d="m 975.2,225.31855 c -6,1.1 -5.5,9 -5.5,9 m -30.5,-9 c -6,1.1 -5.5,9 -5.5,9 m -50,-9 c -6,1.1 -5.5,9 -5.5,9 m -39.5,-9 c -6,1.1 -5.5,9 -5.5,9 m 98.6,-9.1 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -71.9,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 16.6,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -67.6,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 85.1,10.6 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -73.5,9.4 c 6,-1 4.5,-9.4 4.5,-9.4 m 15.7,9.9 c -6,1.1 -5.5,9 -5.5,9 m -37,-9.1 c -6,1.1 -5.5,9 -5.5,9 m 99.1,-8.8 c -6,1.1 -5.5,9 -5.5,9 m 73.4,-9.2 -174.7,-0.1" class="st160" inkscape:label="ATIC_2" inkscape:connector-curvature="0" id="R_ATIC_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 981.4,227.31855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -46.6,-11.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -26.4,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21.8,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st22" inkscape:label="ATIC_2 f" inkscape:connector-curvature="0" id="F_ATIC_2" /><path style="fill:none;stroke:#000000;stroke-width:2.06660008" d="m 926.5,278.81855 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -22.6,8.2 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -25.6,8.2 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -28.6,8.5 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -27.1,8.5 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m 56.9,8.8 c -6,1.1 -5.5,9.2 -5.5,9.2 m -12.5,-9.2 c -6,1.1 -5.5,9.2 -5.5,9.2 m -14,-9.7 c -6,1.1 -5.5,9.2 -5.5,9.2 m -15.5,-9.2 c -6,1.1 -5.5,9.2 -5.5,9.2 m -11,-9.5 c -6,1.1 -5.5,9.2 -5.5,9.2 m -31.5,-9.3 148.9,1.2 m -134.4,-1.1 c -6,1.1 -5.5,9.2 -5.5,9.2 m 2.5,-8.7 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -16.1,-40.9 c 0,49.6 0,49.6 0,49.6" class="st161" inkscape:label="UMPS_2" inkscape:connector-curvature="0" id="R_UMPS_2" /><path style="fill:none;stroke:#000000;stroke-width:1.7335" d="m 1087.7,225.31855 -51.1,-0.3 m 13,0 c -6,0.8 -5.5,6.9 -5.5,6.9 m 12.9,-7.1 c 6,-1 4.5,-9.4 4.5,-9.4 m -18.9,9.8 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 27.3,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -10.4,10 c -6,0.8 -5.5,6.9 -5.5,6.9" class="st162" inkscape:connector-curvature="0" id="R_TNRC6B_ADSL_1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1086.5,227.21855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -9.3,-11 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -17.3,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -14.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st22" inkscape:connector-curvature="0" id="F_TNRC6B_ADSL_1" /><text style="font-size:10px;font-family:Calibri" id="text1703" class="st17 st18" x="1059.1674" y="207.14964">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1256.9,272.21855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.6,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="GUK1_1 f" inkscape:connector-curvature="0" id="F_GUK1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1234.2,272.11855 c -6.9,-2 -6.9,-2 -6.9,-2 l 6.8,-2.4 -1.7,2.2 1.8,2.2 z m 3.6,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="GUK1_1 b" inkscape:connector-curvature="0" id="B_GUK1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1321.7,270.71855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -7.7,8.8 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="RRM2B_TXN_RRM1_RRM2B_1 f" inkscape:connector-curvature="0" id="F_RRM2B_TXN_RRM1_RRM2B_1" /><text style="font-size:10px;font-family:Calibri" id="text1708" class="st17 st18" x="1379.2269" y="295.87714">ADP</text> <text style="font-size:10px;font-family:Calibri" id="text1710" class="st17 st18" x="1397.4281" y="296.41336">ATP</text> <path style="fill:none;stroke:#000000;stroke-width:1.92519999" d="m 1410.2,269.91855 c -24.9,0 -24.9,0 -24.9,0 m 16.5,9.5 c 2.4,-5.9 -3.6,-9.5 -3.6,-9.5 m -2.6,0.1 c -5,0.9 -4.4,9.3 -4.4,9.3" class="st148" inkscape:label="GUK1_2" inkscape:connector-curvature="0" id="R_GUK1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1409.9,272.31855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.5,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="GUK1_2 f" inkscape:connector-curvature="0" id="F_GUK1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1386,271.61855 c -6.9,-2 -6.9,-2 -6.9,-2 l 6.8,-2.4 -1.7,2.2 1.8,2.2 z m 3.5,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="GUK1_2 b" inkscape:connector-curvature="0" id="B_GUK1_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1715" class="st15 st16" x="1420.6156" y="273.48557">dGMP</text> <path style="fill:none;stroke:#000000;stroke-width:1.68470001" d="m 1156.6,213.31855 c -2.4,6.7 3.6,10.9 3.6,10.9 m 15.7,0.2 c -26.9,0 -26.9,0 -26.9,0 m 19.4,-11.1 c 2.4,6.7 -3.6,10.9 -3.6,10.9" class="st163" inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" inkscape:connector-curvature="0" id="R_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1152.2,221.91855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 1.9,-8.8 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st32" inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1 f" inkscape:connector-curvature="0" id="F_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1175.9,222.21855 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z m -8.6,-9.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st32" inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1 b" inkscape:connector-curvature="0" id="B_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1238.3,226.01855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.5,8.6 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" class="st32" inkscape:label="RRM2B_TXN_RRM1_RRM2B_2 f" inkscape:connector-curvature="0" id="F_RRM2B_TXN_RRM1_RRM2B_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 937.8,280.91855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -8.4,-10.3 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -18,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21,-0.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -24,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -39,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st22" inkscape:label="UMPS_2 F" inkscape:connector-curvature="0" id="F_UMPS_2" /><path style="fill:none;stroke:#000000;stroke-width:2.48839998" d="m 965.8,316.01855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2,-7.4 -2.1,1.9 -2.1,-1.8 z m 12.7,-5.1 c 4.3,-1.4 4.3,-1.4 4.3,-1.4 l -4.4,-1 1.1,1.1 -1,1.3 z" class="st164" inkscape:label="CMPK2_CMPK1_1 f" inkscape:connector-curvature="0" id="F_CMPK2_CMPK1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.48839998" d="m 970,295.11855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2,7.4 2.1,-1.9 2.1,1.8 z m 8.5,4.8 c 4.3,-1.4 4.3,-1.4 4.3,-1.4 l -4.4,-1 1.1,1.1 -1,1.3 z" class="st164" inkscape:label="CMPK2_CMPK1_1 b" inkscape:connector-curvature="0" id="B_CMPK2_CMPK1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 933.3,323.31855 c -1.9,-4.3 -1.9,-4.3 -1.9,-4.3 l -1.4,4.4 1.6,-1.2 1.7,1.1 z m -11,11.6 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z" class="st165" inkscape:label="RRM2B_TXN_RRM1_RRM2_1 f" inkscape:connector-curvature="0" id="F_RRM2B_TXN_RRM1_RRM2_1" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 836,334.81855 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z m 8.7,-11.2 c -1.9,-4.3 -1.9,-4.3 -1.9,-4.3 l -1.4,4.4 1.6,-1.2 1.7,1.1 z" class="st165" inkscape:label="CMPK1_DTYMK f" inkscape:connector-curvature="0" id="F_CMPK1_DTYMK" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 859.9,334.81855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -6.8,-10.8 c 1.9,-4.3 1.9,-4.3 1.9,-4.3 l 1.4,4.4 -1.6,-1.2 -1.7,1.1 z" class="st165" inkscape:label="CMPK1_DTYMK b" inkscape:connector-curvature="0" id="B_CMPK1_DTYMK" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 731.1,335.41855 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z m 9.1,-12.4 c -1.7,-4.7 -1.7,-4.7 -1.7,-4.7 l -1.1,4.8 1.3,-1.3 1.5,1.2 z" class="st165" inkscape:label="TYMS " inkscape:connector-curvature="0" id="F_TYMS" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 770.6,330.81855 c 7.2,2.4 7.2,2.4 7.2,2.4 l -7.4,1.9 1.9,-2.1 -1.7,-2.2 z m -4.7,-8.4 c -1.9,-5.3 -1.9,-5.3 -1.9,-5.3 l -1.8,5.3 1.8,-1.3 1.9,1.3 z" class="st165" inkscape:label="TYMS b" inkscape:connector-curvature="0" id="B_TYMS" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 995.7,334.41855 c -7.4,-1.9 -7.4,-1.9 -7.4,-1.9 l 7.2,-2.4 -1.8,2.2 2,2.1 z m 3.8,6 c 1.6,4.7 1.6,4.7 1.6,4.7 l 2.4,-4.6 -2.1,1.1 -1.9,-1.2 z" class="st109" inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3 f" inkscape:connector-curvature="0" id="F_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1093.9,325.01855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m 9.7,9.9 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" class="st73" inkscape:label="CTPS2_GATM_CTPS1 f" inkscape:connector-curvature="0" id="F_CTPS2_GATM_CTPS1" /><text style="font-size:10px;font-family:Calibri" id="text1731" class="st17 st18" x="1236.1302" y="316.99045">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1733" class="st17 st18" x="1216.7562" y="317.36545">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1229.5,324.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" class="st73" inkscape:label="CMPK2_CMPK1_2 b" inkscape:connector-curvature="0" id="B_CMPK2_CMPK1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1246.1,335.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" class="st22" inkscape:label="CMPK2_CMPK1_2 f" inkscape:connector-curvature="0" id="F_CMPK2_CMPK1_2" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 1218.5,332.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" class="st109" inkscape:label="CMPK2_CMPK1_2" inkscape:connector-curvature="0" id="R_CMPK2_CMPK1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.31130004" d="m 1196.6,360.01855 c 2.4,7.2 2.4,7.2 2.4,7.2 l 1.9,-7.4 -2.1,1.9 -2.2,-1.7 z m -6.1,-7.6 c -4.6,1 -4.6,1 -4.6,1 l 2.7,-3.7 0,1.9 1.9,0.8 z" class="st165" inkscape:connector-curvature="0" id="F_RRM2B_TXN_RRM1_RRM2_2" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1739" class="st15 st16" x="1258.7123" y="382.35764">dCMP</text> <text style="font-size:10px;font-family:Calibri" id="text1741" class="st17 st18" x="1236.1302" y="361.80984">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1743" class="st17 st18" x="1216.7562" y="362.36545">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1229.5,369.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" class="st73" inkscape:label="CMPK2_CMPK1_3 b" inkscape:connector-curvature="0" id="B_CMPK2_CMPK1_3" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1246.1,380.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" class="st22" inkscape:label="CMPK2_CMPK1_3 f" inkscape:connector-curvature="0" id="F_CMPK2_CMPK1_3" /><path style="fill:none;stroke:#000000;stroke-width:1.82930005" d="m 1218.5,377.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" class="st109" inkscape:label="CMPK2_CMPK1_3" inkscape:connector-curvature="0" id="R_CMPK2_CMPK1_3" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 236.8,382.21855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -52.2,-23.9 c -6.2,2.5 -6.2,2.5 -6.2,2.5 l 6.5,1.5 -1.7,-1.8 1.4,-2.2 z" class="st73" inkscape:label="MTHFD1_3 f" inkscape:connector-curvature="0" id="F_MTHFD1_3" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 206.6,426.41855 c -6.2,2.5 -6.2,2.5 -6.2,2.5 l 6.5,1.5 -1.7,-1.8 1.4,-2.2 z m 31.7,-24 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" class="st73" inkscape:label="MTHFD1_3 b" inkscape:connector-curvature="0" id="B_MTHFD1_3" /><text style="font-size:9.99962234px;font-family:Calibri" id="text1750" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="301.1604" y="383.42343">H</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text1752" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="307.39139" y="385.42346">2</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1754" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="310.4798" y="383.42337">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 290,301.91855 c 1.6,-5.3 17.5,-4.5 17.5,-4.5 m -2.3,19.7 c -9.8,2.5 -15.9,-3.8 -15.9,-3.8 m -0.3,11.1 0.2,-34.2" class="st79" inkscape:label="MTHFD2_2" inkscape:connector-curvature="0" id="R_MTHFD2_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 287,292.01855 c 2.3,-6.3 2.3,-6.3 2.3,-6.3 l 1.6,6.5 -1.9,-1.7 -2,1.5 z m 15.6,3.3 c 7,1.6 7,1.6 7,1.6 l -6.9,1.6 1.7,-1.6 -1.8,-1.6 z" class="st73" inkscape:label="MTHFD2_2 f" inkscape:connector-curvature="0" id="F_MTHFD2_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 301.3,316.11855 c 7,1.6 7,1.6 7,1.6 l -6.9,1.6 1.7,-1.6 -1.8,-1.6 z m -10.5,6.6 c -2,7.3 -2,7.3 -2,7.3 l -2.3,-7.3 2.2,1.8 2.1,-1.8 z" class="st73" inkscape:label="MTHFD2_2 b" inkscape:connector-curvature="0" id="B_MTHFD2_2" /><text style="font-size:10px;font-family:Calibri" id="text1759" class="st17 st18" transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" x="311.63144" y="319.94809">NADH</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1761" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="307.66241" y="303.30228">NAD</text> <path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 402.2,547.01855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 34,12.7 c 6.3,-2.3 6.3,-2.3 6.3,-2.3 l -6.5,-1.6 1.7,1.9 -1.5,2 z" class="st30" inkscape:label="PEPCK f" inkscape:connector-curvature="0" id="F_PEPCK" /><path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 268.8,649.41855 c 2.3,7.2 2.3,7.2 2.3,7.2 l 2,-7.3 -2.1,1.9 -2.2,-1.8 z m -11.1,-9.3 c -5.1,1.5 -5.1,1.5 -5.1,1.5 l 5.5,1.8 -1.5,-1.7 1.1,-1.6 z" class="st45" inkscape:label="FH_3 f" inkscape:connector-curvature="0" id="F_FH_3" /><path style="fill:none;stroke:#000000;stroke-width:2.23090005" d="m 1444.3,1060.1186 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z m 57.4,10.4 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" class="st37" inkscape:connector-curvature="0" id="B_SLC25A5_SLC25A4_SLC25A6" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1050.3,691.11855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 11.6,-3.8 c 4.7,1.4 4.7,1.4 4.7,1.4 l -5.1,1.5 1.4,-1.4 -1,-1.5 z" class="st14" inkscape:label="TransportGlu f" inkscape:connector-curvature="0" id="F_TransportGlu" /><path style="fill:none;stroke:#000000;stroke-width:2.15549994" d="m 954.1,690.71855 c 2.2,7.1 2.2,7.1 2.2,7.1 l 2.2,-7.1 -2.2,1.8 -2.2,-1.8 z m 12.5,-2.2 c 4.7,1.3 4.7,1.3 4.7,1.3 l -5.1,1.4 1.4,-1.4 -1,-1.3 z" class="st166" inkscape:label="TransportGln f" inkscape:connector-curvature="0" id="F_TransportGln" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 956,636.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 77.1,-13.1 c -1.4,4.7 -1.4,4.7 -1.4,4.7 l -1.5,-5.1 1.4,1.4 1.5,-1 z m -48,0.4 c -1.4,4.7 -1.4,4.7 -1.4,4.7 l -1.5,-5.1 1.4,1.4 1.5,-1 z" class="st14" inkscape:label="GS f" inkscape:connector-curvature="0" id="F_GS" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1022.5,652.11855 c 6.9,2.1 6.9,2.1 6.9,2.1 l -6.9,2.3 1.7,-2.2 -1.7,-2.2 z m -14.8,-6.7 c 1.4,-4.7 1.4,-4.7 1.4,-4.7 l 1.5,5.1 -1.4,-1.4 -1.5,1 z" class="st32" inkscape:label="GLS2 f" inkscape:connector-curvature="0" id="F_GLS2" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1029.4,709.51855 c 6.9,-2.1 6.9,-2.1 6.9,-2.1 l -6.9,-2.3 1.7,2.2 -1.7,2.2 z m -17.8,-8.9 c 0.9,-4.9 0.9,-4.9 0.9,-4.9 l -3.6,3.9 1.9,-0.6 0.8,1.6 z" class="st32" inkscape:label="GLS f" inkscape:connector-curvature="0" id="F_GLS" /><path style="fill:none;stroke:#000000;stroke-width:1.99090004" d="m 1270.4,787.81855 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m 49.7,12.1 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m -17.1,12.1 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m -53.7,0.4 c -5.3,0.6 -5,7.6 -5,7.6 m 89.5,-8 c -99.3,0 -99.3,0 -99.3,0 m 29.8,0.4 c -5.3,0.6 -5,7.6 -5,7.6" class="st167" inkscape:label="CPS1" inkscape:connector-curvature="0" id="R_CPS1" /><text style="font-size:16.00031662px;font-family:Calibri-Bold" id="text1772" class="st15 st16" transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" x="1205.1744" y="771.00928">CP</text> <path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 1351.5,622.81855 c -6.9,-1.7 -6.9,-1.7 -6.9,-1.7 l 5.5,4.6 -0.8,-2.2 2.2,-0.7 z m 11,-3.3 c -1.8,-7.4 -1.8,-7.4 -1.8,-7.4 l -2.5,7.2 2.2,-1.7 2.1,1.9 z" class="st73" inkscape:label="ALDH4A1_2 f" inkscape:connector-curvature="0" id="F_ALDH4A1_2" /><text style="font-size:9.99962234px;font-family:Calibri" id="text1775" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1386.1115" y="542.35461">Gly</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1777" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="1404.1106" y="542.55579">GA</text> <path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 952,862.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -12.1,9.3 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z" class="st22" inkscape:label="CA5B_CA5A f" inkscape:connector-curvature="0" id="F_CA5B_CA5A" /><text style="font-size:9.99962234px;font-family:Calibri" id="text1780" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="665.34772" y="1031.6384">H</text> <text style="font-size:6.09346962px;font-family:Calibri" id="text1782" class="st17 st26" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="671.57819" y="1033.6384">2</text> <text style="font-size:9.99962234px;font-family:Calibri" id="text1784" class="st17 st18" transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" x="674.66699" y="1031.6384">O</text> <path style="fill:none;stroke:#000000;stroke-width:2.29760003" d="m 707.7,1012.8186 c 2.9,-9.7 -3.2,-16.00005 -3.2,-16.00005 m -47.9,0.2 61.6,-0.1 m -33,15.90005 c 2.9,-9.7 -3.2,-16.00005 -3.2,-16.00005 m -14.3,0.3 c -5.3,1.4 -5.1,17.30005 -5.1,17.30005" class="st79" inkscape:label="SHMT1_2 " inkscape:connector-curvature="0" id="R_SHMT1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.09949994" d="m 707,1008.9186 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z m 10.5,-9.70005 c 6.3,-2.3 6.3,-2.3 6.3,-2.3 l -6.5,-1.7 1.7,1.9 -1.5,2.1 z m -33,9.70005 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z" class="st73" inkscape:label="SHMT1_2 f" inkscape:connector-curvature="0" id="F_SHMT1_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1442.5,809.71855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" class="st22" inkscape:label="TransportFolate f" inkscape:connector-curvature="0" id="path1985" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1489.5,814.81855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" class="st22" inkscape:label="SLC16A3_SLC16A1_SLC16A5_2 f" inkscape:connector-curvature="0" id="F_SLC16A3_SLC16A1_SLC16A5_2" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1490.3,756.31855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:transform-center-y="-3.0492074" inkscape:transform-center-x="0.87100132" inkscape:label="Transport_serine b" inkscape:connector-curvature="0" id="B_Transport_serine" /><text style="font-size:10.00011921px;font-family:Calibri" id="text1791" class="st17 st18" transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" x="835.31476" y="1042.428">formate+ATP</text> <text style="font-size:10.00011921px;font-family:Calibri" id="text1793" class="st17 st18" transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" x="891.94086" y="1042.8938">ADP+Pi</text> <path style="fill:none;stroke:#000000;stroke-width:1.80649996" d="m 1525.5,392.51855 c -5.4,-1.7 -4.9,-14 -4.9,-14 m 10.8,14.3 c 5.5,-1.1 4.1,-10.6 4.1,-10.6 m 9,10.6 -33.9,-0.3" class="st116" inkscape:label="LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" inkscape:connector-curvature="0" id="R_LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1543.5,394.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -6.5,-11.3 c -1.7,-5.2 -1.7,-5.2 -1.7,-5.2 l -1.4,5.3 1.5,-1.4 1.6,1.3 z" class="st22" inkscape:label="LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1 f" inkscape:connector-curvature="0" id="F_LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1543.5,348.31855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -6.5,-11.3 c -1.7,-5.2 -1.7,-5.2 -1.7,-5.2 l -1.4,5.3 1.5,-1.4 1.6,1.3 z" class="st22" inkscape:label="CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13 f" inkscape:connector-curvature="0" id="F_CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" /><path style="fill:none;stroke:#000000;stroke-width:9.22049999;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:2" inkscape:connector-curvature="0" d="m 290.9,65.418554 1141.8,0 c 111.4,0 201.6,90.299996 201.6,201.599996 l 0,777.20005 c 0,111.4 -90.3,201.6 -201.6,201.6 l -1141.8,0 c -111.4,0 -201.6,-90.3 -201.6,-201.6 l 0,-777.10005 c 0,-111.4 90.3,-201.699996 201.6,-201.699996 z" class="st168" id="rect3173" /><text style="font-size:10px;font-family:Calibri" id="text1799" class="st17 st18" x="1582.0922" y="894.75116">AMP+PPi</text> <text style="font-size:10px;font-family:Calibri" id="text1801" class="st17 st18" x="1583.309" y="884.0647">ATP+CoA</text> <path style="fill:none;stroke:#000000;stroke-width:1.92519999" d="m 1565.4,888.01855 c 0.9,5 9.3,4.4 9.3,4.4 m 4.5,-10.4 c -8.6,-2.3 -13.9,3.4 -13.9,3.4 m -0.1,-11.9 c 0,24.9 0,24.9 0,24.9" class="st148" inkscape:label="palmitateActivation" inkscape:connector-curvature="0" id="R_palmitateActivation" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1567.3,897.51855 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z m 7.4,-3.5 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" class="st32" inkscape:label="palmitateActivation f" inkscape:connector-curvature="0" id="F_palmitateActivation" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1805" class="st15 st16" x="1547.4984" y="863.4964">Palm</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1807" class="st15 st16" x="1537.4193" y="918.66138">PalmCoA</text> <text style="font-size:10px;font-family:Calibri" id="text1809" class="st17 st18" x="1582.8129" y="953.61157">CoA</text> <text style="font-size:10px;font-family:Calibri" id="text1811" class="st17 st18" x="1582.9476" y="942.5647">carnitine</text> <path style="fill:none;stroke:#000000;stroke-width:1.92519999" d="m 1565.2,932.01855 c 0,24.9 0,24.9 0,24.9 m 9.6,-16.5 c -5.9,-2.4 -9.5,3.6 -9.5,3.6 m 0.1,2.5 c 0.9,5 9.3,4.4 9.3,4.4" class="st148" inkscape:label="carnitineAcylTransferaseI" inkscape:connector-curvature="0" id="R_carnitineAcylTransferaseI" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1567.3,933.41855 c -2,-6.9 -2,-6.9 -2,-6.9 l -2.4,6.8 2.2,-1.7 2.2,1.8 z m 7.4,8.6 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" class="st32" inkscape:label="carnitineAcylTransferaseI b" inkscape:connector-curvature="0" id="B_carnitineAcylTransferaseI" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1567.3,956.01855 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z m 7.4,-3.5 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" class="st32" inkscape:label="carnitineAcylTransferaseI f" inkscape:connector-curvature="0" id="F_carnitineAcylTransferaseI" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1816" class="st15 st16" x="1509.2845" y="977.52167">PalmCarnitine</text> <path style="fill:none;stroke:#000000;stroke-width:2.56680012" d="m 1477.7,972.41855 c 5.3,-1.5 4.6,-15.8 4.6,-15.8 m -29,0 c -2.5,10 3.7,16.2 3.7,16.2 m -18.4,0.1 c 58.9,0 58.9,0 58.9,0" class="st169" inkscape:label="translocase" inkscape:connector-curvature="0" id="R_translocase" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1483.8,956.91855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -43.4,14 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z" class="st32" inkscape:label="translocase f" inkscape:connector-curvature="0" id="F_translocase" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1454.7,956.91855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 40.6,13.9 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z" class="st32" inkscape:connector-curvature="0" id="path3243" /><text style="font-size:10px;font-family:Calibri" id="text1821" class="st17 st18" x="1476.4476" y="948.5647">carnitine</text> <text style="font-size:10px;font-family:Calibri" id="text1823" class="st17 st18" x="1425.4476" y="948.5647">carnitine</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1825" class="st15 st16" x="1333.4193" y="977.16138">PalmCarnitine</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1315.8,962.01855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 3.6,7.4 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z" class="st32" inkscape:connector-curvature="0" id="path3291" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1305.3,962.01855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -8.5,7.4 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z" class="st32" inkscape:label="carnitineAcylTransferaseII f" inkscape:connector-curvature="0" id="F_carnitineAcylTransferaseII" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1309.9,971.31855 c 5,-0.9 4.4,-9.3 4.4,-9.3 m -10.6,-0.1 c -2.4,5.9 3.6,9.5 3.6,9.5 m -12,0 c 24.9,0 24.9,0 24.9,0" class="st32" inkscape:label="carnitineAcylTransferaseII " inkscape:connector-curvature="0" id="R_carnitineAcylTransferaseII" /><text style="font-size:10px;font-family:Calibri" id="text1830" class="st17 st18" x="1311.5248" y="953.61157">CoA</text> <text style="font-size:10px;font-family:Calibri" id="text1832" class="st17 st18" x="1271.8422" y="952.50116">carnitine</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1834" class="st15 st16" x="1222.6273" y="976.7356">PalmCoA</text> <text style="font-size:10px;font-family:Calibri" id="text1836" class="st17 st18" x="1206.2504" y="990.83716">7 CoA</text> <text style="font-size:10px;font-family:Calibri" id="text1838" class="st17 st18" x="1171.7504" y="990.83716">7 NAD</text> <text style="font-size:10px;font-family:Calibri" id="text1840" class="st17 st18" x="1141.7504" y="990.83716">7 FAD</text> <text style="font-size:10px;font-family:Calibri" id="text1842" class="st17 st18" x="1110.2504" y="990.83716">7 H</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1844" class="st17 st26" x="1123.809" y="992.83716">2</text> <text style="font-size:10px;font-family:Calibri" id="text1846" class="st17 st18" x="1126.8978" y="990.83716">O</text> <text style="font-size:10px;font-family:Calibri" id="text1848" class="st17 st18" x="1165.7504" y="951.83716">7 NADH</text> <text style="font-size:10px;font-family:Calibri" id="text1850" class="st17 st18" x="1128.2504" y="951.83716">7 FADH</text> <text style="font-size:6.09369993px;font-family:Calibri" id="text1852" class="st17 st26" x="1157.7816" y="953.83716">2</text> <text style="font-size:10px;font-family:Calibri" id="text1854" class="st17 st18" x="1105.7504" y="951.83716">7 H</text> <path style="fill:none;stroke:#000000;stroke-width:1.93280005" d="m 1120.2,971.91855 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m 35.6,12.1 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m 35.6,12.1 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m -58.4,11.7 c 5.6,1.5 5.5,11.8 5.5,11.8 m 24.5,-11.8 c 5.6,1.5 5.5,11.8 5.5,11.8 m 29,-11.8 c 5.6,1.5 5.5,11.8 5.5,11.8 m 13.9,-12.1 c 5.6,1.5 5.5,11.8 5.5,11.8 m 10.1,-11.6 -112,0.1" class="st170" inkscape:label="betaOxidation " inkscape:connector-curvature="0" id="R_betaOxidation" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1109.3,969.41855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 8.5,-8.8 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 31.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 31.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z" class="st32" inkscape:label="betaOxidation f" inkscape:connector-curvature="0" id="F_betaOxidation" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1858" class="st15 st16" x="1042.6273" y="976.7356">8 AcCoA</text> <path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1567.3,874.91855 c -2,-6.9 -2,-6.9 -2,-6.9 l -2.4,6.8 2.2,-1.7 2.2,1.8 z m 7.4,8.6 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" class="st32" inkscape:label="palmitateActivation b" inkscape:connector-curvature="0" id="B_palmitateActivation" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1861" class="st15 st16" x="1486.4927" y="427.78244">ATP</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1863" class="st15 st16" x="1554.2847" y="427.81766">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:1.80649996" d="m 1544.5,425.81855 -33.9,-0.3" class="st116" inkscape:label="ATPmaintenance " inkscape:connector-curvature="0" id="R_ATPmaintenance" /><path style="fill:none;stroke:#000000;stroke-width:2.5" d="m 1543.5,427.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" class="st22" inkscape:label="ATPmaintenancef" inkscape:connector-curvature="0" id="F_ATPmaintenance" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1867" class="st15 st38" x="259.638" y="851.84009">Pi</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1869" class="st15 st16" x="278.91238" y="912.47101">Orn</text> <path style="fill:none;stroke:#000000;stroke-width:3.19709992" d="m 237.8,908.91855 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" class="st171" inkscape:label="UniportOrnithine" inkscape:connector-curvature="0" id="R_UniportOrnithine" /><path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 267.4,895.31855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 l 0,0 z" class="st140" inkscape:label="UniportOrnithine f" inkscape:connector-curvature="0" id="F_UniportOrnithine" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1873" class="st15 st38" x="261.46759" y="887.15851">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1875" class="st15 st38" x="226.01099" y="888.6438">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1877" class="st15 st16" x="180.79909" y="912.72589">Orn</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1879" class="st15 st16" x="303.034" y="950.73657">Orn</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1881" class="st15 st16" x="170.7791" y="950.48169">Orn</text> <path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 283.9,934.31855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -50,2.4 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m -26.6,8.8 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" class="st140" inkscape:connector-curvature="0" id="path3519" /><path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 218.4,948.01855 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 65.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -43.2,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 29.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" class="st45" inkscape:label="CotraspArgOrnA" inkscape:connector-curvature="0" id="R_CotraspArgOrnA" /><path style="fill:none;stroke:#000000;stroke-width:2.35560012" d="m 214.4,936.71855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 76.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -23.1,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" class="st46" inkscape:label="CotraspArgOrnA f" inkscape:connector-curvature="0" id="F_CotraspArgOrnA" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1886" class="st15 st38" x="259.9368" y="926.9231">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1888" class="st15 st38" x="226.01099" y="927.6438">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1890" class="st15 st38" x="199.5208" y="926.62427">Arg</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1892" class="st15 st38" x="273.05161" y="926.62427">Arg</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1894" class="st15 st16" x="300.10669" y="992.00116">Orn</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1896" class="st15 st16" x="176.7791" y="991.49146">Orn</text> <path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 289.9,974.81855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -76.6,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z m 60.1,-11.2 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" class="st140" inkscape:label="CotraspArgOrnB f" inkscape:connector-curvature="0" id="F_CotraspArgOrnB" /><path style="fill:none;stroke:#000000;stroke-width:3.13730001" d="m 227.1,988.41855 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 62.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -41.5,14 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 27.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" class="st172" inkscape:label="CotraspArgOrnB" inkscape:connector-curvature="0" id="R_CotraspArgOrnB" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1900" class="st15 st38" x="265.9368" y="967.4231">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1902" class="st15 st38" x="232.01099" y="968.1438">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1904" class="st15 st38" x="205.5208" y="967.12427">Arg</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1906" class="st15 st38" x="279.05161" y="967.12427">Arg</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1908" class="st15 st16" x="303.034" y="1030.2366">Ci</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1910" class="st15 st16" x="182.74879" y="1032.5325">Ci</text> <path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 283.9,1013.8186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -50,2.4 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m -26.6,8.8 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" class="st140" inkscape:label="CotraspArgCitrA b" inkscape:connector-curvature="0" id="B_CotraspArgCitrA" /><path style="fill:none;stroke:#000000;stroke-width:2.82299995" d="m 218.4,1027.5186 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 65.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -43.2,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 29.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" class="st45" inkscape:label="CotraspArgCitrA" inkscape:connector-curvature="0" id="R_CotraspArgCitrA" /><path style="fill:none;stroke:#000000;stroke-width:2.35560012" d="m 214.4,1016.2186 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 76.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -23.1,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" class="st46" inkscape:label="CotraspArgCitrA f" inkscape:connector-curvature="0" id="F_CotraspArgCitrA" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1915" class="st15 st38" x="259.9368" y="1006.4231">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1917" class="st15 st38" x="226.01099" y="1007.1438">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1919" class="st15 st38" x="199.5208" y="1006.1243">Arg</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1921" class="st15 st38" x="273.05161" y="1006.1243">Arg</text> <path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 282.4,1048.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -76.6,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z m 60.1,-11.2 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" class="st140" inkscape:label="CotraspArgCitrB f" inkscape:connector-curvature="0" id="F_CotraspArgCitrB" /><path style="fill:none;stroke:#000000;stroke-width:3.13730001" d="m 219.6,1061.9186 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 62.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -41.5,14 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 27.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" class="st172" inkscape:label="CotraspArgCitrB" inkscape:connector-curvature="0" id="R_CotraspArgCitrB" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1925" class="st15 st38" x="258.4368" y="1040.9231">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1927" class="st15 st38" x="224.51099" y="1041.6438">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1929" class="st15 st38" x="198.0208" y="1040.6243">Arg</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1931" class="st15 st38" x="271.55161" y="1040.6243">Arg</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1933" class="st15 st16" x="292.57349" y="1066.5403">Ci</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1935" class="st15 st16" x="182.74879" y="1067.0325">Ci</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1937" class="st15 st16" x="289.01248" y="1101.4709">Arg</text> <path style="fill:none;stroke:#000000;stroke-width:3.19709992" d="m 237.8,1097.9186 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" class="st171" inkscape:label="UniportArginine" inkscape:connector-curvature="0" id="R_UniportArginine" /><path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 267.4,1084.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" class="st140" inkscape:label="UniportArginine f" inkscape:connector-curvature="0" id="F_UniportArginine" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1941" class="st15 st38" x="261.46759" y="1076.1584">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1943" class="st15 st38" x="226.01099" y="1077.6438">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1945" class="st15 st16" x="180.79909" y="1101.7258">Arg</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1947" class="st15 st16" x="295.41238" y="1140.4709">Ci</text> <path style="fill:none;stroke:#000000;stroke-width:3.19709992" d="m 246.8,1136.9186 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" class="st171" inkscape:label="UniportCitrulline" inkscape:connector-curvature="0" id="R_UniportCitrulline" /><path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 276.4,1123.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" class="st140" inkscape:label="UniportCitrulline f" inkscape:connector-curvature="0" id="F_UniportCitrulline" /><text style="font-size:14px;font-family:Calibri-Bold" id="text1951" class="st15 st38" x="270.46759" y="1115.1584">H</text> <text style="font-size:14px;font-family:Calibri-Bold" id="text1953" class="st15 st38" x="235.37189" y="1114.1194">H</text> <text style="font-size:16px;font-family:Calibri-Bold" id="text1955" class="st15 st16" x="202.06329" y="1141.4475">Ci</text> <path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 275.3,1099.8186 c 2.4,-0.8 4.8,-1.6 7.2,-2.4 -2.5,-0.6 -4.9,-1.3 -7.4,-1.9 0.6,0.7 1.3,1.4 1.9,2.1 -0.6,0.8 -1.1,1.5 -1.7,2.2 z m -40.9,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" class="st140" inkscape:label="UniportArginine b" inkscape:connector-curvature="0" id="B_UniportArginine" /><path style="fill:none;stroke:#000000;stroke-width:2.32780004" d="m 243,1123.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.7,0.5 1.4,1 2.2,1.5 z m 41.3,15.5 c 2.4,-0.8 4.8,-1.6 7.2,-2.4 -2.5,-0.6 -4.9,-1.3 -7.4,-1.9 0.6,0.7 1.3,1.4 1.9,2.1 -0.6,0.8 -1.1,1.5 -1.7,2.2 z" class="st140" inkscape:label="UniportCitrulline b" inkscape:connector-curvature="0" id="B_UniportCitrulline" /><path style="fill:none;stroke:#000000;stroke-width:2.22029996" d="m 1039.7789,1224.1775 0.3,50.4" class="st68" inkscape:label="DM_10formylTHFc" inkscape:connector-curvature="0" id="R_DM_10formylTHFc" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1960" class="st15 st16" x="984.76355" y="1218.4149">10-formylTHF</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 1037.8789,1273.7775 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="DM_10formylTHFc f" inkscape:connector-curvature="0" id="F_DM_10formylTHFc" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1963" class="st15 st16" x="739.07251" y="1219.4495">carnitine</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 769.6,1234.7186 0,47.6" class="st63" inkscape:label="DM_Carnitine" inkscape:connector-curvature="0" id="R_DM_Carnitine" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 769.8,1233.4186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" class="st63" inkscape:label="DM_Carnitine f" inkscape:connector-curvature="0" id="F_DM_Carnitine" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 1382.6,1269.2186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" class="st63" inkscape:label="Palmitate_DM_COOP f" inkscape:connector-curvature="0" id="F_Palmitate_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 1384.7,1222.0186 0,47.6" class="st63" inkscape:label="Palmitate_DM_COOP" inkscape:connector-curvature="0" id="R_Palmitate_DM_COOP" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1969" class="st15 st16" x="1377.4066" y="1218.3489">Palm</text> <path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1305.8,1276.7186 -0.3,-48.1" class="st14" inkscape:label="Arginine_DM_COOP" inkscape:connector-curvature="0" id="R_Arginine_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1267.8,1232.1186 2.2,-7.7 2.2,7.7 -2.2,-1.9 -2.2,1.9 z" class="st69" inkscape:label="Glutamate_DM_COOP b" inkscape:connector-curvature="0" id="B_Glutamate_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:3.16359997" d="m 643.6,1230.3186 2.2,-6.9 2.2,6.9 -2.2,-1.7 -2.2,1.7 z" class="st65" inkscape:label="Ex_NH3 b" inkscape:connector-curvature="0" id="B_Ex_NH3" /><text style="font-size:10px;font-family:Calibri" id="text1974" class="st17 st18" x="1314.7279" y="204.19505">ATP</text> <text style="font-size:10px;font-family:Calibri" id="text1976" class="st17 st18" x="1294.9379" y="204.31226">ADP</text> <path style="fill:none;stroke:#000000;stroke-width:1.68470001" d="m 1308.1,213.31855 c -2.4,6.7 3.6,10.9 3.6,10.9 m 15.7,0.2 c -26.9,0 -26.9,0 -26.9,0 m 19.4,-11.1 c 2.4,6.7 -3.6,10.9 -3.6,10.9" class="st163" inkscape:label="AK" inkscape:connector-curvature="0" id="R_AK" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1303.7,221.91855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 1.9,-8.8 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st32" inkscape:label="AK b" inkscape:connector-curvature="0" id="B_AK" /><path style="fill:none;stroke:#000000;stroke-width:2.44919991" d="m 1327.4,222.21855 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z m -8.6,-9.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" class="st32" inkscape:label="AK f" inkscape:connector-curvature="0" id="F_AK" /><text style="font-size:16px;font-family:Calibri-Bold" id="text1981" class="st15 st16" x="1341.2035" y="225.97145">dAMP</text> <text style="font-size:10px;font-family:Calibri" id="text1983" class="st17 st18" x="422.99298" y="130.87186">H</text> <text style="font-size:6.5px;font-family:Calibri" id="text1985" class="st17 st173" x="429.22339" y="132.87186">2</text> <text style="font-size:10px;font-family:Calibri" id="text1987" class="st17 st18" x="432.51788" y="130.87186">O</text> <text style="font-size:10px;font-family:Calibri" id="text1989" class="st17 st18" x="427.66238" y="118.75516">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 457.5,136.01855 0,-31.1 0,31.1 z m -0.4,-14.7 c -0.9,-5.5 -11.1,-5.3 -11.1,-5.3 m -3.6,11.8 c 8.8,2.9 14.6,-3.3 14.6,-3.3" class="st76" inkscape:label="G6PPer" inkscape:connector-curvature="0" id="R_G6PPer" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 447,117.71855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.1,-10.7 c -1.7,-7.299996 -1.7,-7.299996 -1.7,-7.299996 l -1.7,7.299996 1.7,-1.8 1.7,1.8 z" class="st30" inkscape:label="F G6PPer" inkscape:connector-curvature="0" id="F_G6PPer" /><path style="fill:none;stroke:#000000;stroke-width:2.0948" d="m 457.9,245.51855 0,-31.1 0,31.1 z m -0.4,-14.8 c -0.9,-5.5 -11.1,-5.3 -11.1,-5.3 m -3.6,11.9 c 8.8,2.9 14.6,-3.3 14.6,-3.3" class="st76" inkscape:transform-center-y="-61.654422" inkscape:transform-center-x="138.9285" inkscape:connector-curvature="0" id="R_FBP" /><path style="fill:none;stroke:#000000;stroke-width:1.87170005" d="m 447.4,227.21855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.1,-10.7 c -1.7,-7.3 -1.7,-7.3 -1.7,-7.3 l -1.7,7.3 1.7,-1.8 1.7,1.8 z" class="st30" inkscape:transform-center-y="-76.278967" inkscape:transform-center-x="138.06632" inkscape:label="FBP f" inkscape:connector-curvature="0" id="F_FBP" /><text style="font-size:10px;font-family:Calibri" id="text1995" class="st17 st18" x="424.16238" y="240.49146">H</text> <text style="font-size:6.5px;font-family:Calibri" id="text1997" class="st17 st173" x="430.39288" y="242.49146">2</text> <text style="font-size:10px;font-family:Calibri" id="text1999" class="st17 st18" x="433.6868" y="240.49146">O</text> <text style="font-size:10px;font-family:Calibri" id="text2001" class="st17 st18" x="428.83179" y="228.37425">Pi</text> <path style="fill:none;stroke:#000000;stroke-width:2.17810011" d="m 1405.8,1229.0186 0,47.6" class="st63" inkscape:label="Palmitate_UP_COOP" inkscape:connector-curvature="0" id="R_Palmitate_UP_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1403.7,1233.9186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="Palmitate_UP_COOP f" inkscape:connector-curvature="0" id="F_Palmitate_UP_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 767.6,1278.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="DM_Carnitine b" inkscape:connector-curvature="0" id="B_DM_Carnitine" /><path style="fill:none;stroke:#000000;stroke-width:2.67510009" d="m 964.1,1232.4186 -2.2,-7.1 -2.2,7.1 2.2,-1.8 2.2,1.8 z" class="st64" inkscape:label="UptakeCitrate f" inkscape:connector-curvature="0" id="F_UptakeCitrate" /><path style="fill:none;stroke:#000000;stroke-width:2.67510009" d="m 962,1278.6186 0,-46.6" class="st64" inkscape:label="DM_Citrate" inkscape:connector-curvature="0" id="R_DM_Citrate" /><text style="font-size:16px;font-family:Calibri-Bold" id="text2008" class="st15 st16" x="952.39581" y="1218.1301">Cit</text> <path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 959.6,1276.4186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="UptakeCitrate b" inkscape:connector-curvature="0" id="B_UptakeCitrate" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1174.9998,1273.8805 -2.1,7.3 -2.3,-7.3 2.2,1.8 2.2,-1.8 z" class="st14" inkscape:label="Glucose_DM_COOP f" inkscape:connector-curvature="0" id="F_Glucose_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1137.2,1273.5186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" class="st69" inkscape:label="LactateL_DM_COOP f" inkscape:connector-curvature="0" id="F_DM_LactateL" /><path style="fill:none;stroke:#000000;stroke-width:2.22930002" d="m 1139.2,1223.4186 0,50.5" class="st69" inkscape:label="LactateL_DM_COOP" inkscape:connector-curvature="0" id="R_LactateL_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1231.89,1231.8186 2.2,-7.3 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" class="st14" inkscape:label="Glutamine_DM_COOP b" inkscape:connector-curvature="0" id="B_Glutamine_DM_COOP" /><path style="fill:none;stroke:#000000;stroke-width:2.18210006" d="m 1233.89,1279.4186 0,-48" class="st14" inkscape:label="Glutamine_DM_COOP" inkscape:connector-curvature="0" id="R_Glutamine_DM_COOP" /><flowRoot xml:space="preserve" id="flowRoot5366" style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="translate(-20.6,18.418554)"><flowRegion id="flowRegion5368"><rect id="rect5370" width="1165.1471" height="77.465683" x="306.70087" y="-39.523308" /></flowRegion><flowPara id="flowPara5372" /></flowRoot><flowRoot xml:space="preserve" id="TitoloConfronto" style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" inkscape:label="TitoloConfronto" transform="translate(-18.364224,56.426743)"><flowRegion id="flowRegion5376"><rect id="rect5378" width="1869.6877" height="68.569115" x="301.95807" y="-69.56102" /></flowRegion><flowPara id="TitleText" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:45px;font-family:sans-serif;-inkscape-font-specification:sans-serif">TITOLO: TITOLOTITOLO </flowPara></flowRoot><flowRoot xml:space="preserve" id="flowRoot5382" style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="translate(-16.64767,38.180207)"><flowRegion id="flowRegion5384"><rect id="rect5386" width="275.00043" height="149.79698" x="1681.3033" y="204.59315" /></flowRegion><flowPara id="flowPara5390" style="font-style:normal;font-variant:normal;font-weight:bold;font-stretch:normal;font-family:sans-serif;-inkscape-font-specification:'sans-serif Bold'">Fold Change</flowPara></flowRoot><flowRoot xml:space="preserve" id="FC_min" style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="translate(-8.622366,131.05768)" inkscape:label="FC_min"><flowRegion id="flowRegion5384-2"><rect id="rect5386-9" width="275.00043" height="149.79698" x="1681.3033" y="204.59315" /></flowRegion><flowPara id="Val_FC_min">min: </flowPara></flowRoot><flowRoot xml:space="preserve" id="FC_max" style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="translate(-17.492772,95.648076)" inkscape:label="FC_max"><flowRegion id="flowRegion5384-2-2"><rect id="rect5386-9-9" width="275.00043" height="149.79698" x="1681.3033" y="204.59315" /></flowRegion><flowPara id="Val_FC_max">max:</flowPara></flowRoot></svg>