Mercurial > repos > bimib > marea_2
changeset 241:1058a2803472 draft
Uploaded
author | luca_milaz |
---|---|
date | Sat, 03 Aug 2024 13:59:47 +0000 |
parents | b28a2a7569ac |
children | 83a62e7743b3 |
files | marea_2/flux_to_map.py |
diffstat | 1 files changed, 18 insertions(+), 61 deletions(-) [+] |
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--- a/marea_2/flux_to_map.py Sat Aug 03 13:47:37 2024 +0000 +++ b/marea_2/flux_to_map.py Sat Aug 03 13:59:47 2024 +0000 @@ -62,72 +62,34 @@ default = 1.5, help = 'Fold-Change threshold (default: %(default)s)') - parser.add_argument( - "-ne", "--net", - type = utils.Bool("net"), default = False, - help = "choose if you want net enrichment for RPS") parser.add_argument( '-op', '--option', type = str, choices = ['datasets', 'dataset_class'], help='dataset or dataset and class') - - #RAS: - parser.add_argument( - "-ra", "--using_RAS", - type = utils.Bool("using_RAS"), default = True, - help = "choose whether to use RAS datasets.") parser.add_argument( - '-id', '--input_data', + '-idf', '--input_data_fluxes', type = str, - help = 'input dataset') + help = 'input dataset fluxes') parser.add_argument( - '-ic', '--input_class', - type = str, - help = 'sample group specification') + '-icf', '--input_class_fluxes', + type = str, + help = 'sample group specification fluxes') parser.add_argument( - '-ids', '--input_datas', - type = str, - nargs = '+', - help = 'input datasets') - - parser.add_argument( - '-na', '--names', + '-idsf', '--input_datas_fluxes', type = str, nargs = '+', - help = 'input names') - - #RPS: - parser.add_argument( - "-rp", "--using_RPS", - type = utils.Bool("using_RPS"), default = False, - help = "choose whether to use RPS datasets.") - - parser.add_argument( - '-idr', '--input_data_rps', - type = str, - help = 'input dataset rps') + help = 'input datasets fluxes') parser.add_argument( - '-icr', '--input_class_rps', - type = str, - help = 'sample group specification rps') - - parser.add_argument( - '-idsr', '--input_datas_rps', + '-naf', '--names_fluxes', type = str, nargs = '+', - help = 'input datasets rps') - - parser.add_argument( - '-nar', '--names_rps', - type = str, - nargs = '+', - help = 'input names rps') + help = 'input names fluxes') #Output: parser.add_argument( @@ -151,7 +113,7 @@ choices = [utils.Model.HMRcore, utils.Model.ENGRO2, utils.Model.Custom]) args :argparse.Namespace = parser.parse_args() - if args.using_RAS and not args.using_RPS: args.net = False + args.net = True return args @@ -448,7 +410,7 @@ # we assume the reactionIds also don't encode reaction dir if they don't mind it when styling the map. if not mindReactionDir: return "R_" + reactionId - #TODO: this is clearly something we need to make consistent in RPS + #TODO: this is clearly something we need to make consistent in fluxes return (reactionId[:-3:-1] + reactionId[:-2]) if reactionId[:-2] in ["_F", "_B"] else f"F_{reactionId}" # "Pyr_F" --> "F_Pyr" def toStyleStr(self, *, downSizedForTips = False) -> str: @@ -467,12 +429,12 @@ INVALID_ARROW = Arrow(Arrow.MIN_W, ArrowColor.Invalid) INSIGNIFICANT_ARROW = Arrow(Arrow.MIN_W, ArrowColor.Invalid, isDashed = True) -def applyRpsEnrichmentToMap(rpsEnrichmentRes :Dict[str, Union[Tuple[float, FoldChange], Tuple[float, FoldChange, float, float]]], metabMap :ET.ElementTree, maxNumericZScore :float) -> None: +def applyFluxesEnrichmentToMap(fluxesEnrichmentRes :Dict[str, Union[Tuple[float, FoldChange], Tuple[float, FoldChange, float, float]]], metabMap :ET.ElementTree, maxNumericZScore :float) -> None: """ - Applies RPS enrichment results to the provided metabolic map. + Applies fluxes enrichment results to the provided metabolic map. Args: - rpsEnrichmentRes : RPS enrichment results. + fluxesEnrichmentRes : fluxes enrichment results. metabMap : the metabolic map to edit. maxNumericZScore : biggest finite z-score value found. @@ -482,7 +444,7 @@ Returns: None """ - for reactionId, values in rpsEnrichmentRes.items(): + for reactionId, values in fluxesEnrichmentRes.items(): pValue = values[0] foldChange = values[1] z_score = values[2] @@ -692,7 +654,7 @@ return for reactId, enrichData in tmp.items(): tmp[reactId] = tuple(enrichData) - applyRpsEnrichmentToMap(tmp, core_map, max_z_score) + applyFluxesEnrichmentToMap(tmp, core_map, max_z_score) def computePValue(dataset1Data: List[float], dataset2Data: List[float]) -> Tuple[float, float]: """ @@ -883,13 +845,8 @@ # getMap will None-check the customPath and panic when the model IS custom but there's no file (good). A cleaner # solution can be derived from my comment in FilePath.fromStrPath - #if ARGS.using_RAS: - # ids, class_pat = getClassesAndIdsFromDatasets(ARGS.input_datas, ARGS.input_data, ARGS.input_class, ARGS.names) - # computeEnrichment(core_map, class_pat, ids) - - if ARGS.using_RPS: - ids, class_pat = getClassesAndIdsFromDatasets(ARGS.input_datas_rps, ARGS.input_data_rps, ARGS.input_class_rps, ARGS.names_rps) - computeEnrichment(core_map, class_pat, ids, fromRAS = False) + ids, class_pat = getClassesAndIdsFromDatasets(ARGS.input_datas_fluxes, ARGS.input_data_fluxes, ARGS.input_class_fluxes, ARGS.names_fluxes) + computeEnrichment(core_map, class_pat, ids, fromRAS = False) # create output files: TODO: this is the same comparison happening in "maps", find a better way to organize this if ARGS.comparison == "manyvsmany":