# HG changeset patch # User bioinformatics_lab_ufsc # Date 1637803596 0 # Node ID ef26009cd70aca855c52dc3fbcf915dec7e2f000 Uploaded version 1.1 diff -r 000000000000 -r ef26009cd70a ._epibuilder-1.1.jar Binary file ._epibuilder-1.1.jar has changed diff -r 000000000000 -r ef26009cd70a ._epibuilder-1.1.xml Binary file ._epibuilder-1.1.xml has changed diff -r 000000000000 -r ef26009cd70a ._test-data Binary file ._test-data has changed diff -r 000000000000 -r ef26009cd70a epibuilder-1.1.jar Binary file epibuilder-1.1.jar has changed diff -r 000000000000 -r ef26009cd70a epibuilder-1.1.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/epibuilder-1.1.xml Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,586 @@ + + Predict B cell epitopes + + Java + Blastp + Makeblastdb + + + + + + + > d means defalt threshold + -->*# + + #**# + #set param = '' + #set nomethod = '' + #set proteomes = '' + + #**# + #if $bepi_type.bepipred_origin == 'y': + #set bepipred_origin = '-o' + #**# + #elif $bepi_type.bepipred_origin == 'id': + #set bepipred_origin = '-jobid ' + str($bepi_type.job_id) + #else: + #set bepipred_origin = '' + #end if + + #**# + #if $emini_method.emini_choice == 'eminiyes': + #if $emini_method.emini_t.t_emini == 't_emini_choice' + #set param += 'emini:' + str($emini_method.emini_t.thresh_em_value) + ';' + #else: + #set param += 'emini:d;' + #end if + #end if + + #**# + #if $parker_method.parker_choice == 'parkeryes': + #if $parker_method.parker_t.t_parker == 't_parker_choice' + #set param += 'parker:' + str($parker_method.parker_t.thresh_park_value) + ';' + #else: + #set param += 'parker:d;' + #end if + #end if + + #**# + #if $chou_method.chou_choice == 'chouyes': + #if $chou_method.chou_t.t_chou == 't_chou_choice' + #set param += 'chou_fosman:' + str($chou_method.chou_t.thresh_chou_value) + ';' + #else: + #set param += 'chou_fosman:d;' + #end if + #end if + + #**# + #if $karplus_method.karplus_choice == 'karplusyes': + #if $karplus_method.karplus_t.t_karplus == 't_karplus_choice' + #set param += 'karplus_schulz:' + str($karplus_method.karplus_t.thresh_karplus_value) + ';' + #else: + #set param += 'karplus_schulz:d;' + #end if + #end if + + #**# + #if $kolaskar_method.kolaskar_choice == 'kolaskaryes': + #if $kolaskar_method.kolaskar_t.t_kolaskar == 't_kolaskar_choice' + #set param += 'kolaskar:' + str($kolaskar_method.kolaskar_t.thresh_kolaskar_value) + ';' + #else: + #set param += 'kolaskar:d;' + #end if + #end if + + + + #**# + #if proteomes == '-proteomes ': + #set proteomes = '' + #end if + + + #**# + + #if $use_search.search_use_bool == "use": + #**# + #if $use_search.prot_input: + #for $file in $use_search.prot_input: + #set proteomes += str($file.prot_name) + '=' + str($file.prot_file) + ';' + #end for + #end if + #if $use_search.prot_input: + #if $use_search.blast.blast_search == 'blastyes': + #set blast_command = 'task=' + str($use_search.blast.blast_task) + #set blast_command += ';identity=' + str($use_search.blast.blast_id) + ';cover=' + str($use_search.blast.blast_cover) + ';word-size=' + str($use_search.blast.blast_wordsize) + #set blast_command += ';makeblastdb_path=makeblastdb;blastp_path=blastp' + #end if + #end if + #end if + + #**# + + java -jar $__tool_directory__/epibuilder-1.1.jar + + #**# + #**# + #if $bepi_type.bepipred_origin != 'id': + -b ${bepi_type.bepi_out} + #end if + -t ${tresh_bepi2} + ${bepipred_origin} + #if $param: + -p "${param}" + #end if + -f "${basename}" + -min_len ${min_length} + -max_len ${max_length} + #if $proteomes: + -proteomes + "${proteomes}" + #if $use_search.blast.blast_search == 'blastyes': + -blast "${blast_command}" + #end if + #end if + + #if $use_search.check_use_hit == 'nousehit': + -nohitacc + #end if + #**# + >log.log 2>log.log; + + mv $basename-epibuilder.xlsx EpiBuilder_report.xlsx; + + #**# + mv ${basename}-epibuilder.txt EpiBuilder; + + + ]]> + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + use_search['search_use_bool'] is True and use_search['blast']['blast_search'] is True + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +**How to Run** + +First, you must have a file with epitopes predicted by Bepipred 2.0 or have one job submmited into bepipred's server. + +.. class:: warningmark + +Input this file (or jobID) and specify if Bepipred 2.0 was ran online or command-line based through bcell standalone suite. + +Select methods that you want to check your epitopes for validation. + +Give a threshold for each method (or use default threshold). + +Optionaly, you can search validated epitopes in proteomes datasets, as many as you wish. + +.. class:: warningmark + +If you want to search using Blastp, this software and Makeblastdb must be avaliable on your server's $PATH. + +----- + +**Outputs** + + +**Summary** : Prediction overview + +**Protein Summary** : Show proteins that have epitopes predicted + +**Fasta** : Epitopes' sequences + +**Topology** : Show epitope match in each method, aminoacid per aminoacid + +**Score** : Detailed score for aminoacids + +**Epitope Detail** : Properties of each predicted epitope + +**Parameters** : Softwares, thresholds and parameters used for prediction + +**Xls Report** : Table with epitope detail, protein summary, topology and scores + +**Collection with blast files** : All blast results for each proteome + + +----- + +.. class:: infomark + +**For more information, checkout our GitHub page**: https://github.com/bioinfo-ufsc/EpiBuilder + +----- + +Please cite methods used in your analysis, available bellow + +| Bioinformatics Lab - UFSC - 2021 + + + + 10.1093/nar/gkx346 + 10.1016/0014-5793(90)80535-q + 10.1002/9780470122921.ch2 + 10.1021/bi00367a013 + https://doi.org/10.1007/BF01195768 + doi:10.1128/jvi.55.3.836-839.1985 + 10.1371/journal.pcbi.1006791 + https://doi.org/10.1093/nar/gky379 + + + diff -r 000000000000 -r ef26009cd70a test-data/._command-epifinder-epitope-detail.tsv Binary file test-data/._command-epifinder-epitope-detail.tsv has changed diff -r 000000000000 -r ef26009cd70a test-data/._command-epifinder-epitopes-fasta.fasta Binary file test-data/._command-epifinder-epitopes-fasta.fasta has changed diff -r 000000000000 -r ef26009cd70a test-data/._command-epifinder-parameters.txt Binary file test-data/._command-epifinder-parameters.txt has changed diff -r 000000000000 -r ef26009cd70a test-data/._command-epifinder-protein-summary.tsv 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test-data/._online-test_proteom.phr Binary file test-data/._online-test_proteom.phr has changed diff -r 000000000000 -r ef26009cd70a test-data/._online-test_proteom.pin Binary file test-data/._online-test_proteom.pin has changed diff -r 000000000000 -r ef26009cd70a test-data/._online-test_proteom.psq Binary file test-data/._online-test_proteom.psq has changed diff -r 000000000000 -r ef26009cd70a test-data/._online-test_proteom_blast.csv Binary file test-data/._online-test_proteom_blast.csv has changed diff -r 000000000000 -r ef26009cd70a test-data/._proteom.fasta Binary file test-data/._proteom.fasta has changed diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-epitope-detail.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-epitope-detail.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,4 @@ +N Id Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length MW(kDa) I.P Hydropathy All Matches Cover Avg Cover BepiPred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar test_proteom_count test_proteom_acc test_proteom_count test_proteom_id +1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation PETQSSHSAW 73 83 N 0 - 10 1.13 5.25 -1.40 0.90 0.98 0.65 2.57 4.19 1.13 1.04 0.99 1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 4WFF_B(100.00,100.00) +2 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation AIFLKWHVPPELVR 149 163 N 0 - 14 1.71 8.80 0.42 0.07 0.60 0.64 0.82 -1.83 0.83 0.96 1.10 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) +3 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation LKWHVPPELVRVLSA 150 165 N 0 - 15 1.74 8.75 0.39 0.07 0.59 0.63 0.81 -1.70 0.84 0.96 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-epitopes-fasta.fasta --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-epitopes-fasta.fasta Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,6 @@ +>1-PETQSSHSAW +PETQSSHSAW +>2-AIFLKWHVPPELVR +AIFLKWHVPPELVR +>3-LKWHVPPELVRVLSA +LKWHVPPELVRVLSA diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-parameters.txt --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-parameters.txt Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,28 @@ + +---- Running Parameters ---- +BepiPred-2.0 Threshold : 0.6 +Min epitope length : 10 +Max epitope length : 30 + +---- Softwares Threshold ---- +Emini : 0.8 +Parker : 0.8 +Chou Fosman : 0.8 +Karplus Schulz : 0.8 +Kolaskar : 0.8 + +---- Proteomes ---- +Alias File +test_proteom /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta + +---- Blast ---- +Identity : 90.0 +Cover : 90.0 +Word size : 4 +Task blastp-short: blastp-short + +---- Stats ---- +Processed proteins : 6 +NGlycosylated proteins : 0 +Identified epitopes : 3 +N-glycosylated epitopes: 0 diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-protein-summary.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-protein-summary.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,7 @@ +Id Epitopes N-Glyc +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 0 0 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 0 0 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 0 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 0 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 0 0 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 0 0 diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-scores.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-scores.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,1141 @@ +Id Position Residue Bepipred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar MW IP Hydropathy +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 1 V 0.23 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 2 R 0.27 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 3 S 0.31 0.23 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 4 L 0.33 0.45 1.63 1.03 0.98 1.09 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 5 N 0.39 0.19 0.84 1.04 0.97 1.07 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 6 C 0.40 0.28 0.84 1.04 0.96 1.07 121.15 5.52 2.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 7 T 0.41 0.56 1.34 1.04 0.96 1.05 119.12 5.19 -0.70 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 8 L 0.42 0.47 3.59 1.16 0.99 1.01 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 9 R 0.44 1.50 3.44 1.08 1.03 1.05 174.20 9.75 -4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 10 D 0.45 1.80 4.10 1.05 1.07 0.99 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 11 S 0.46 4.37 4.17 1.06 1.11 0.99 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 12 Q 0.45 2.99 6.41 1.18 1.12 0.96 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 13 Q 0.45 1.48 4.50 1.13 1.12 1.01 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 14 K 0.43 0.82 2.54 0.99 1.08 1.09 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 15 S 0.43 0.47 1.01 0.87 1.03 1.06 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 16 L 0.43 0.36 1.09 0.93 0.99 1.06 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 17 V 0.42 0.18 1.04 1.02 0.97 1.04 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 18 M 0.42 0.21 0.53 1.09 0.98 1.06 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 19 S 0.41 0.39 -0.67 1.05 1.01 1.08 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 20 G 0.39 0.92 1.76 1.07 1.03 1.02 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 21 P 0.41 0.76 0.97 1.08 1.03 1.01 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 22 Y 0.42 1.14 2.39 1.14 1.01 1.02 181.19 5.52 -1.30 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 23 E 0.43 1.16 1.76 1.03 0.99 1.03 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 24 L 0.43 0.62 -0.37 0.89 0.98 1.08 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 25 K 0.43 0.54 -0.37 0.81 0.97 1.09 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 26 A 0.44 0.26 -1.41 0.73 0.96 1.10 89.09 5.57 1.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 27 L 0.46 0.54 -1.67 0.77 0.95 1.12 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 28 H 0.48 0.27 0.46 0.91 0.96 1.07 155.16 6.74 -3.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 29 L 0.52 0.46 0.50 0.90 0.99 1.08 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 30 Q 0.54 0.92 1.63 1.02 1.03 1.05 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 31 G 0.58 0.67 2.34 1.02 1.07 0.99 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 32 Q 0.59 1.41 3.16 0.99 1.08 0.96 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 33 D 0.61 1.41 5.33 1.04 1.08 0.92 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 34 M 0.60 2.47 5.33 1.04 1.06 0.92 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 35 E 0.58 1.06 3.99 0.89 1.05 1.00 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 36 Q 0.54 0.47 2.60 0.82 1.04 1.05 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 37 Q 0.51 0.41 -0.14 0.70 1.01 1.08 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 38 V 0.47 0.32 1.39 0.82 0.98 1.11 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 39 V 0.46 0.18 -0.33 0.80 0.95 1.10 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 40 F 0.44 0.14 -0.26 0.86 0.93 1.10 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 41 S 0.42 0.16 -2.43 0.81 0.92 1.11 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 42 M 0.41 0.16 -2.43 0.81 0.93 1.11 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 43 S 0.44 0.33 -1.04 0.88 0.93 1.06 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 44 F 0.46 0.24 1.09 1.01 0.95 1.03 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 45 V 0.50 0.43 1.27 0.92 0.98 1.01 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 46 Q 0.53 0.55 2.99 0.94 1.02 1.01 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 47 G 0.55 0.85 2.99 0.94 1.07 1.01 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 48 E 0.56 1.84 5.30 1.07 1.10 0.97 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 49 E 0.58 1.78 7.26 1.21 1.11 0.89 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 50 S 0.58 3.59 7.21 1.21 1.11 0.88 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 51 N 0.56 1.45 5.26 1.06 1.10 0.92 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 52 D 0.52 1.30 4.44 1.17 1.07 0.95 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 53 K 0.49 0.72 2.80 1.14 1.04 1.03 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 54 I 0.45 0.45 2.17 1.03 1.00 1.03 131.17 5.52 4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 55 P 0.42 0.22 -0.14 0.89 0.97 1.10 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 56 V 0.39 0.11 -0.76 0.90 0.94 1.10 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 57 A 0.39 0.13 -2.89 0.84 0.93 1.15 89.09 5.57 1.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 58 L 0.39 0.17 -0.93 0.92 0.94 1.12 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 59 G 0.39 0.39 -0.11 0.81 0.97 1.09 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 60 L 0.41 0.78 1.23 0.88 1.00 1.02 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 61 K 0.43 1.51 1.93 1.01 1.03 0.98 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 62 E 0.44 1.26 1.93 1.01 1.05 0.98 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 63 K 0.44 2.39 0.84 0.95 1.04 1.02 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 64 N 0.44 0.99 0.84 0.95 1.01 1.02 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 65 L 0.44 0.76 0.96 1.01 0.97 1.03 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 66 Y 0.43 0.20 0.04 1.07 0.93 1.11 181.19 5.52 -1.30 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 67 L 0.43 0.09 -1.30 1.00 0.92 1.18 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 68 S 0.43 0.09 -3.61 0.86 0.91 1.25 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 69 C 0.43 0.12 -1.49 0.92 0.92 1.20 121.15 5.52 2.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 70 V 0.43 0.24 0.21 0.97 0.95 1.16 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 71 L 0.44 0.30 2.96 1.09 0.98 1.10 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 72 K 0.45 1.14 2.84 1.03 1.01 1.09 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 73 D 0.46 2.37 2.94 1.08 1.03 1.04 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 74 D 0.45 4.14 4.21 1.14 1.05 0.97 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 75 K 0.45 1.71 4.21 1.14 1.05 0.97 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 76 P 0.44 1.77 4.26 1.14 1.04 0.99 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 77 T 0.45 0.87 1.51 1.02 1.01 1.04 119.12 5.19 -0.70 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 78 L 0.46 0.76 1.20 0.91 0.99 1.04 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 79 Q 0.48 0.66 1.31 0.97 0.98 1.05 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 80 L 0.49 0.34 0.49 0.83 0.98 1.10 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 81 E 0.50 0.68 1.17 0.90 1.00 1.09 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 82 S 0.52 0.61 2.79 1.03 1.02 1.06 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 83 V 0.55 1.48 2.74 1.04 1.04 1.05 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 84 D 0.56 1.37 5.06 1.17 1.05 0.98 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 85 P 0.59 1.61 3.67 1.23 1.05 1.03 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 86 K 0.59 3.35 3.04 1.24 1.05 1.03 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 87 N 0.59 4.01 4.39 1.32 1.04 0.97 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 88 Y 0.58 5.18 3.77 1.25 1.04 0.98 181.19 5.52 -1.30 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 89 P 0.56 5.18 4.29 1.18 1.05 0.96 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 90 K 0.55 3.19 2.87 1.12 1.06 0.95 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 91 K 0.53 3.52 2.99 1.00 1.06 0.96 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 92 K 0.52 4.56 4.07 0.99 1.06 0.92 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 93 M 0.51 4.46 4.37 0.90 1.04 0.90 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 94 E 0.49 1.93 2.24 0.85 1.03 0.92 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 95 K 0.48 0.72 0.90 0.77 1.02 0.98 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 96 R 0.46 0.63 -1.23 0.71 0.99 1.01 174.20 9.75 -4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 97 F 0.45 0.58 0.37 0.85 0.97 1.00 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 98 V 0.46 0.58 0.07 0.89 0.96 1.01 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 99 F 0.47 0.21 -1.89 0.81 0.96 1.04 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 100 N 0.49 0.42 -1.37 0.78 0.98 1.04 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 101 K 0.50 0.39 -1.20 0.76 1.00 1.05 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 102 I 0.51 0.73 0.33 0.92 1.00 0.96 131.17 5.52 4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 103 E 0.54 0.73 2.64 1.05 1.00 0.92 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 104 I 0.54 0.73 2.46 0.97 1.01 0.94 131.17 5.52 4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 105 N 0.56 0.86 0.33 0.91 1.02 0.98 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 106 N 0.54 0.86 2.59 0.95 1.03 0.94 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 107 K 0.54 1.06 0.16 0.93 1.02 0.98 146.19 8.75 -3.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 108 L 0.51 1.15 2.41 0.97 1.00 0.93 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 109 E 0.49 0.95 2.34 0.95 0.99 0.97 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 110 F 0.48 0.48 1.64 0.82 0.99 1.01 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 111 E 0.47 1.01 1.69 0.82 0.99 1.02 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 112 S 0.45 0.51 1.69 0.82 0.99 1.00 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 113 A 0.45 0.90 0.87 0.93 0.99 1.03 89.09 5.57 1.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 114 Q 0.42 0.84 3.19 1.07 0.99 0.98 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 115 F 0.42 0.66 0.64 1.10 0.98 0.99 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 116 P 0.39 1.02 -0.56 1.06 0.98 1.01 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 117 N 0.39 0.41 -2.00 1.03 0.96 1.02 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 118 W 0.38 0.64 -1.93 1.10 0.95 1.02 204.23 5.52 -0.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 119 Y 0.37 0.60 0.13 1.15 0.94 1.00 181.19 5.52 -1.30 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 120 I 0.38 0.50 0.76 1.14 0.96 0.99 131.17 5.52 4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 121 S 0.39 0.82 0.61 1.05 1.00 1.02 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 122 T 0.41 0.53 2.34 1.01 1.04 1.05 119.12 5.19 -0.70 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 123 S 0.43 1.31 3.73 0.95 1.07 1.00 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 124 Q 0.45 1.57 5.87 1.11 1.06 0.95 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 125 A 0.47 1.07 4.34 0.99 1.05 0.92 89.09 5.57 1.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 126 E 0.48 1.24 3.90 1.07 1.02 0.94 147.13 4.00 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 127 N 0.49 0.53 2.44 0.94 0.99 1.00 132.12 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 128 M 0.48 0.46 0.27 0.88 0.97 1.01 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 129 P 0.45 0.22 -1.34 0.87 0.95 1.03 115.13 5.96 -1.60 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 130 V 0.45 0.13 -1.64 0.99 0.94 1.04 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 131 F 0.45 0.13 -1.83 0.99 0.96 1.05 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 132 L 0.46 0.09 -0.41 1.13 1.00 1.06 131.17 5.52 3.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 133 G 0.47 0.11 0.10 1.13 1.04 1.03 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 134 G 0.49 0.23 1.49 1.20 1.09 0.98 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 135 G 0.51 0.46 4.23 1.32 1.12 0.95 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 136 G 0.52 0.33 4.40 1.31 1.12 0.93 75.07 5.52 -0.40 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 137 Q 0.54 0.48 4.33 1.22 1.11 0.94 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 138 D 0.54 0.80 4.94 1.21 1.09 0.94 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 139 I 0.52 0.70 2.81 1.07 1.06 0.97 131.17 5.52 4.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 140 T 0.49 0.59 2.74 0.98 1.04 0.97 119.12 5.19 -0.70 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 141 D 0.49 0.35 1.29 0.93 1.01 0.95 133.10 3.80 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 142 F 0.48 0.86 0.71 0.86 0.98 0.97 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 143 T 0.47 0.52 0.54 0.88 0.95 0.96 119.12 5.19 -0.70 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 144 M 0.47 0.23 -0.73 0.81 0.93 1.03 149.21 5.28 1.90 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 145 Q 0.47 0.35 -1.23 0.81 0.93 1.05 146.15 5.52 -3.50 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 146 F 0.41 0.33 1.01 0.93 0.00 1.04 165.19 5.52 2.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 147 V 0.38 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 148 S 0.33 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 149 S 0.29 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 1 V 0.27 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 2 E 0.33 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 3 C 0.39 0.34 0.00 0.00 0.00 0.00 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 4 D 0.45 0.71 2.13 1.06 0.96 1.10 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 5 F 0.52 0.34 1.34 1.08 0.98 1.08 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 6 S 0.53 0.52 -1.09 1.05 1.00 1.13 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 7 P 0.54 0.42 -0.36 1.09 1.01 1.08 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 8 L 0.54 0.48 -0.97 1.10 1.02 1.08 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 9 L 0.53 0.52 1.09 1.15 1.03 1.05 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 10 S 0.53 0.52 0.46 1.17 1.04 1.06 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 11 G 0.53 0.97 0.46 1.17 1.06 1.06 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 12 T 0.52 2.03 2.63 1.22 1.07 1.03 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 13 P 0.52 1.12 3.41 1.21 1.06 1.05 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 14 P 0.51 1.78 2.21 1.17 1.03 1.07 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 15 Q 0.50 1.98 2.40 1.17 1.00 1.05 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 16 V 0.50 1.11 0.34 1.12 0.97 1.08 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 17 Y 0.50 1.44 0.86 1.04 0.96 1.06 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 18 N 0.51 1.62 1.16 0.96 0.96 1.03 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 19 F 0.51 1.80 -1.01 0.91 0.97 1.07 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 20 K 0.49 0.85 -1.01 0.91 0.99 1.07 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 21 R 0.49 0.46 -2.06 0.83 0.99 1.06 174.20 9.75 -4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 22 L 0.50 0.77 -2.31 0.74 0.98 1.08 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 23 V 0.50 0.62 0.00 0.88 0.97 1.03 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 24 F 0.52 0.17 -0.61 0.91 0.97 1.10 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 25 T 0.53 0.33 -0.21 0.99 0.97 1.09 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 26 N 0.54 0.69 0.83 1.07 0.98 1.07 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 27 C 0.54 1.29 2.36 1.22 0.97 0.99 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 28 N 0.55 0.74 2.36 1.22 0.96 1.01 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 29 Y 0.57 0.66 2.36 1.22 0.96 1.01 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 30 N 0.56 2.47 2.17 1.14 0.97 1.03 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 31 L 0.56 1.27 0.66 1.06 0.99 1.01 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 32 T 0.56 0.67 -1.66 0.92 1.00 1.08 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 33 K 0.55 0.56 -0.46 0.96 1.00 1.05 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 34 L 0.55 0.56 -2.77 0.82 0.99 1.12 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 35 L 0.55 0.33 -2.77 0.82 0.97 1.10 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 36 S 0.56 0.22 -2.59 0.89 0.95 1.11 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 37 L 0.57 0.20 -3.93 0.82 0.94 1.18 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 38 F 0.57 0.39 -1.61 0.96 0.94 1.11 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 39 S 0.58 0.49 1.13 1.08 0.96 1.06 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 40 V 0.58 0.51 -1.11 0.96 0.98 1.07 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 41 N 0.57 0.85 0.94 1.02 0.99 1.02 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 42 D 0.58 0.34 2.46 1.10 0.99 1.06 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 43 F 0.57 0.62 2.46 1.10 0.98 1.06 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 44 T 0.56 0.66 3.84 1.17 0.98 1.01 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 45 C 0.57 0.28 1.70 1.01 0.99 1.07 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 46 S 0.55 0.43 1.20 1.01 1.00 1.09 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 47 Q 0.54 0.46 2.81 1.14 1.02 1.08 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 48 I 0.54 0.87 2.37 1.10 1.03 1.10 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 49 S 0.52 0.66 2.47 1.02 1.02 1.05 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 50 P 0.51 0.27 0.40 0.88 1.00 1.07 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 51 A 0.51 0.38 -0.16 0.84 0.97 1.08 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 52 A 0.51 0.38 1.91 0.98 0.95 1.06 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 53 I 0.52 0.40 1.99 0.99 0.94 1.03 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 54 A 0.53 0.21 1.89 0.95 0.95 1.08 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 55 S 0.55 0.33 1.31 1.02 0.96 1.09 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 56 N 0.55 0.63 1.94 1.13 0.97 1.08 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 57 C 0.56 0.83 4.01 1.26 0.97 1.06 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 58 Y 0.57 0.51 2.40 1.25 0.98 1.09 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 59 S 0.58 0.22 0.33 1.12 0.98 1.11 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 60 S 0.57 0.34 -1.99 0.98 0.98 1.18 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 61 L 0.56 0.37 -0.76 1.02 0.97 1.10 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 62 I 0.55 0.43 -0.76 1.02 0.95 1.10 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 63 L 0.54 0.28 -3.00 0.90 0.94 1.11 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 64 D 0.53 0.45 -3.00 0.90 0.93 1.11 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 65 Y 0.52 1.00 -1.96 0.98 0.93 1.10 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 66 F 0.52 1.88 -0.51 1.13 0.93 1.09 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 67 S 0.53 0.93 -0.51 1.13 0.93 1.09 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 68 Y 0.54 0.80 -1.01 1.12 0.94 1.11 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 69 P 0.55 0.91 -1.34 1.04 0.94 1.06 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 70 L 0.56 1.36 0.79 1.10 0.95 1.04 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 71 S 0.57 1.16 0.79 1.10 0.97 1.04 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 72 M 0.58 1.25 2.49 1.15 1.01 0.99 149.21 5.28 1.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 73 K 0.59 1.25 0.87 1.02 1.04 1.02 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 74 S 0.61 1.25 3.11 1.14 1.05 0.99 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 75 D 0.63 0.94 1.66 1.00 1.04 1.04 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 76 L 0.63 0.63 3.19 1.12 1.02 1.07 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 77 S 0.62 0.63 3.30 1.18 1.00 1.08 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 78 V 0.61 0.38 2.67 1.07 1.00 1.09 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 79 S 0.59 0.46 2.06 1.09 1.01 1.09 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 80 S 0.58 0.53 3.67 1.22 1.03 1.06 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 81 A 0.58 0.50 1.60 1.08 1.04 1.08 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 82 G 0.57 0.50 3.06 1.21 1.05 1.03 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 83 P 0.56 0.64 2.99 1.15 1.05 1.03 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 84 I 0.55 0.55 0.74 1.03 1.03 1.04 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 85 S 0.55 0.90 1.44 1.16 1.02 1.00 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 86 Q 0.56 0.91 0.36 1.10 1.00 1.04 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 87 F 0.57 2.59 0.87 1.03 0.98 1.02 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 88 N 0.58 3.35 2.87 1.10 0.99 1.00 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 89 Y 0.58 2.59 2.87 1.10 1.01 1.00 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 90 K 0.58 2.59 0.70 1.05 1.03 1.01 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 91 Q 0.58 2.16 2.94 1.16 1.05 1.00 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 92 S 0.57 2.22 2.94 1.16 1.05 1.00 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 93 F 0.57 1.71 3.51 1.22 1.04 0.99 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 94 S 0.57 1.43 3.44 1.21 1.05 0.98 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 95 N 0.56 0.57 2.79 1.24 1.04 1.04 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 96 P 0.54 0.54 0.54 1.12 1.03 1.07 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 97 T 0.53 0.28 0.71 1.10 1.00 1.08 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 98 C 0.52 0.15 -1.53 0.98 0.96 1.12 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 99 L 0.51 0.10 -2.23 0.85 0.93 1.16 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 100 I 0.50 0.10 -1.79 0.77 0.92 1.14 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 101 L 0.51 0.13 -3.06 0.71 0.92 1.20 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 102 A 0.51 0.25 -2.96 0.76 0.93 1.15 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 103 T 0.52 0.48 -1.34 0.81 0.94 1.13 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 104 V 0.51 0.94 0.80 0.96 0.95 1.08 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 105 P 0.52 0.76 0.80 0.96 0.95 1.08 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 106 H 0.53 0.76 1.24 1.01 0.96 1.06 155.16 6.74 -3.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 107 N 0.54 1.49 1.24 1.01 0.97 1.06 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 108 L 0.53 0.67 0.63 1.00 0.99 1.02 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 109 T 0.54 0.72 1.07 0.92 1.01 1.00 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 110 T 0.53 0.89 1.59 0.93 1.03 0.98 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 111 I 0.52 1.67 0.89 0.92 1.04 1.02 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 112 T 0.50 0.95 0.89 0.92 1.05 1.02 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 113 K 0.51 1.32 0.96 0.93 1.05 1.02 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 114 P 0.50 2.95 -0.06 0.96 1.04 1.06 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 115 L 0.50 2.74 2.01 1.09 1.02 1.04 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 116 K 0.51 2.15 1.00 1.12 1.00 1.07 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 117 Y 0.52 0.97 -0.96 1.04 0.97 1.10 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 118 S 0.53 1.90 -0.26 1.05 0.95 1.06 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 119 Y 0.53 1.90 1.87 1.11 0.95 1.02 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 120 I 0.53 0.65 1.26 1.13 0.96 1.09 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 121 N 0.55 0.65 2.46 1.18 0.98 1.06 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 122 K 0.55 0.81 2.13 1.11 1.00 1.05 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 123 C 0.56 1.00 1.09 1.03 1.01 1.04 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 124 S 0.56 0.51 0.91 1.05 1.01 1.05 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 125 R 0.56 0.34 0.84 1.03 1.00 1.08 174.20 9.75 -4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 126 F 0.56 1.07 1.46 1.09 0.99 1.07 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 127 L 0.56 1.34 2.69 1.13 1.00 1.00 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 128 S 0.56 1.34 2.36 1.06 1.01 0.98 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 129 D 0.56 2.23 2.50 1.06 1.02 0.98 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 130 D 0.54 4.68 4.93 1.08 1.04 0.95 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 131 R 0.53 2.59 5.71 1.07 1.04 0.97 174.20 9.75 -4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 132 T 0.53 2.40 5.09 1.08 1.04 0.97 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 133 E 0.53 2.49 4.51 1.02 1.04 0.99 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 134 V 0.53 1.05 1.77 0.89 1.03 1.05 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 135 P 0.53 0.54 0.64 0.83 1.02 1.12 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 136 Q 0.53 0.50 0.90 0.91 1.00 1.10 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 137 L 0.55 0.68 0.09 0.90 0.99 1.13 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 138 V 0.57 0.71 1.61 1.05 0.98 1.05 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 139 N 0.59 0.71 2.17 0.98 0.98 1.04 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 140 A 0.61 1.35 1.04 1.00 0.99 1.06 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 141 N 0.60 2.43 3.29 1.12 1.00 1.03 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 142 Q 0.60 2.34 4.11 1.26 1.01 0.98 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 143 Y 0.60 1.24 3.31 1.21 1.01 1.07 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 144 S 0.59 0.57 2.49 1.19 1.00 1.12 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 145 P 0.58 0.44 2.41 1.17 0.99 1.15 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 146 C 0.55 0.20 0.41 1.10 0.96 1.17 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 147 V 0.52 0.11 0.16 1.01 0.94 1.20 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 148 S 0.51 0.11 -0.47 1.02 0.93 1.21 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 149 I 0.51 0.27 0.16 1.01 0.95 1.20 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 150 V 0.51 0.53 0.70 0.97 0.99 1.13 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 151 P 0.51 0.30 0.70 0.97 1.02 1.13 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 152 S 0.51 0.44 -1.66 0.91 1.04 1.11 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 153 T 0.51 1.03 0.60 0.94 1.03 1.07 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 154 V 0.51 1.12 2.56 1.08 1.01 1.00 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 155 W 0.52 0.83 3.07 1.09 1.00 0.97 204.23 5.52 -0.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 156 E 0.52 0.95 3.57 1.09 1.02 0.95 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 157 D 0.52 2.02 2.56 1.12 1.03 0.98 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 158 G 0.51 3.00 2.81 1.21 1.04 0.95 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 159 D 0.52 3.40 4.84 1.21 1.04 0.95 133.10 3.80 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 160 Y 0.52 4.07 4.54 1.25 1.02 0.96 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 161 Y 0.52 7.12 3.97 1.18 1.01 0.98 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 162 R 0.53 3.52 1.84 1.04 1.01 1.04 174.20 9.75 -4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 163 K 0.53 3.01 1.34 1.03 1.02 1.06 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 164 Q 0.53 2.97 1.91 1.09 1.03 1.04 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 165 L 0.55 1.25 0.87 1.01 1.03 1.06 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 166 S 0.55 1.08 1.39 0.98 1.03 1.05 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 167 P 0.56 0.62 1.39 1.06 1.04 1.05 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 168 L 0.55 0.74 1.34 1.14 1.04 1.02 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 169 E 0.54 0.55 3.47 1.28 1.06 0.97 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 170 G 0.54 0.37 1.11 1.21 1.07 0.95 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 171 G 0.54 0.37 -0.50 1.08 1.06 0.98 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 172 G 0.54 0.16 0.29 1.07 1.03 1.00 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 173 W 0.56 0.16 -0.53 1.06 0.98 1.03 204.23 5.52 -0.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 174 L 0.56 0.22 -0.41 1.04 0.96 1.05 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 175 V 0.58 0.22 -0.41 1.04 0.96 1.05 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 176 A 0.58 0.28 -0.30 1.02 0.99 1.07 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 177 S 0.59 0.49 1.87 1.02 1.04 1.07 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 178 G 0.60 0.49 2.66 1.01 1.07 1.09 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 179 S 0.61 0.49 3.49 1.03 1.07 1.05 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 180 T 0.62 0.36 2.59 1.02 1.03 1.01 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 181 V 0.63 0.53 2.40 0.95 0.99 1.00 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 182 A 0.63 0.69 2.70 0.84 0.96 0.99 89.09 5.57 1.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 183 M 0.63 0.82 2.63 0.77 0.96 0.99 149.21 5.28 1.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 184 T 0.62 0.91 0.57 0.72 0.99 1.04 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 185 E 0.63 1.57 1.96 0.79 1.00 0.99 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 186 Q 0.62 1.57 1.06 0.78 1.00 0.96 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 187 L 0.61 1.07 2.47 0.92 0.98 0.96 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 188 Q 0.59 0.54 0.41 0.86 0.95 0.99 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 189 M 0.57 0.31 0.11 0.98 0.93 0.99 149.21 5.28 1.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 190 G 0.56 0.26 -1.89 0.91 0.93 1.01 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 191 F 0.55 0.22 0.17 0.96 0.94 0.96 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 192 G 0.55 0.16 -1.21 0.89 0.95 1.02 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 193 I 0.55 0.29 0.24 0.95 0.95 1.04 131.17 5.52 4.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 194 T 0.54 0.52 -0.84 0.89 0.95 1.08 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 195 V 0.55 0.52 1.29 1.02 0.95 1.05 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 196 Q 0.56 1.06 1.21 0.94 0.96 1.06 146.15 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 197 Y 0.57 1.06 3.10 1.01 0.98 1.02 181.19 5.52 -1.30 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 198 G 0.59 2.30 3.36 1.09 1.02 1.00 75.07 5.52 -0.40 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 199 T 0.59 1.78 4.81 1.23 1.05 0.95 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 200 T 0.58 0.84 3.43 1.16 1.06 1.00 119.12 5.19 -0.70 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 201 N 0.57 0.46 3.90 1.17 1.05 1.04 132.12 5.52 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 202 S 0.57 0.49 3.39 1.16 1.02 1.07 105.09 5.24 -0.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 203 V 0.56 0.68 3.46 1.17 1.00 1.07 117.15 5.49 4.20 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 204 C 0.57 0.35 1.40 1.11 0.99 1.12 121.15 5.52 2.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 205 P 0.56 0.45 1.51 1.00 1.00 1.13 115.13 5.96 -1.60 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 206 K 0.56 0.52 -0.73 0.88 1.00 1.14 146.19 8.75 -3.90 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 207 L 0.50 0.99 0.10 0.90 0.00 1.09 131.17 5.52 3.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 208 E 0.44 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 209 F 0.38 0.00 0.00 0.00 0.00 0.00 165.19 5.52 2.80 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 210 A 0.32 0.00 0.00 0.00 0.00 0.00 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 R 0.18 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 S 0.22 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 3 T 0.27 1.31 0.00 0.00 0.00 0.00 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 4 T 0.29 0.67 0.69 0.88 1.03 1.04 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 5 L 0.32 0.42 -1.23 0.83 0.99 1.09 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 6 L 0.31 0.24 -3.47 0.71 0.95 1.13 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 7 A 0.31 0.17 -3.91 0.66 0.93 1.15 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 8 L 0.30 0.17 -5.97 0.61 0.91 1.20 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 9 L 0.29 0.15 -5.19 0.60 0.91 1.22 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 10 A 0.28 0.12 -5.19 0.60 0.91 1.22 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 11 L 0.27 0.12 -6.80 0.59 0.91 1.24 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 12 V 0.25 0.23 -5.76 0.67 0.91 1.23 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 13 L 0.25 0.19 -5.76 0.67 0.91 1.23 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 14 L 0.27 0.17 -6.59 0.64 0.90 1.28 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 15 Y 0.28 0.31 -4.34 0.76 0.91 1.24 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 16 L 0.29 0.37 -3.00 0.91 0.93 1.17 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 17 V 0.31 0.45 -1.39 0.92 0.95 1.14 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 18 S 0.32 0.24 -1.39 0.92 0.97 1.14 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 19 G 0.31 0.21 -1.64 0.83 0.98 1.17 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 20 A 0.33 0.25 -1.64 0.83 0.96 1.15 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 21 L 0.35 0.37 -0.51 0.90 0.94 1.08 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 22 V 0.36 0.37 -1.14 0.79 0.93 1.09 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 23 F 0.37 0.30 -3.27 0.65 0.92 1.14 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 24 R 0.40 0.64 -2.46 0.66 0.93 1.11 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 25 A 0.43 1.49 -0.29 0.72 0.96 1.08 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 26 L 0.44 2.66 0.54 0.86 0.99 1.03 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 27 E 0.46 1.85 2.16 0.91 1.03 1.03 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 28 Q 0.51 3.17 2.67 0.88 1.06 1.03 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 29 P 0.52 6.66 3.23 0.93 1.07 1.02 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 30 H 0.53 6.66 5.40 0.98 1.06 0.99 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 31 E 0.57 3.88 4.59 0.97 1.06 1.02 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 32 Q 0.59 4.35 4.59 0.97 1.06 1.02 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 33 Q 0.59 6.26 4.89 0.89 1.05 0.99 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 34 A 0.57 6.26 5.70 0.86 1.05 0.95 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 35 Q 0.57 2.98 3.27 0.84 1.04 1.01 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 36 R 0.57 1.70 3.23 0.92 1.03 0.99 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 37 E 0.57 2.92 3.49 0.89 1.02 0.97 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 38 L 0.57 1.25 2.66 0.87 1.02 1.01 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 39 G 0.58 1.25 2.40 0.86 1.02 0.99 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 40 E 0.57 1.25 2.91 0.83 1.02 0.99 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 41 V 0.54 3.04 2.61 0.87 1.03 1.00 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 42 R 0.53 2.66 2.61 0.87 1.03 0.98 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 43 E 0.55 1.27 0.49 0.73 1.03 1.03 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 44 K 0.55 3.34 -0.03 0.76 1.01 1.04 146.19 8.75 -3.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 45 F 0.55 1.72 0.80 0.79 0.98 0.99 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 46 L 0.54 1.35 0.50 0.79 0.96 1.02 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 47 R 0.54 1.05 -0.31 0.90 0.94 1.05 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 48 A 0.54 0.65 -0.93 0.92 0.93 1.12 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 49 H 0.54 0.58 -0.14 0.91 0.93 1.16 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 50 P 0.57 0.40 2.10 1.03 0.93 1.13 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 51 C 0.57 0.66 2.93 1.10 0.94 1.13 121.15 5.52 2.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 52 V 0.58 0.84 3.49 1.15 0.97 1.12 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 53 S 0.58 0.94 4.30 1.12 1.01 1.09 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 54 D 0.58 1.45 2.69 0.98 1.03 1.11 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 55 Q 0.58 1.93 3.30 1.04 1.05 1.04 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 56 E 0.55 1.19 2.51 1.05 1.03 1.02 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 57 L 0.53 0.59 0.27 0.93 1.00 1.05 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 58 G 0.53 0.24 -2.30 0.79 0.97 1.09 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 59 L 0.51 0.27 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 60 L 0.47 0.57 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 61 I 0.44 0.43 -1.56 0.78 0.96 1.10 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 62 K 0.44 0.53 -2.07 0.65 0.98 1.13 146.19 8.75 -3.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 63 E 0.43 1.07 0.67 0.78 0.98 1.07 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 64 V 0.42 1.54 2.29 0.79 0.97 1.04 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 65 A 0.44 0.64 2.11 0.80 0.96 1.06 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 66 D 0.46 0.36 2.11 0.88 0.95 1.05 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 67 A 0.46 0.48 1.81 1.00 0.97 1.05 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 68 L 0.47 0.47 3.16 1.15 1.00 0.98 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 69 G 0.51 0.29 3.16 1.15 1.03 0.98 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 70 G 0.53 0.47 3.16 1.15 1.05 0.98 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 71 G 0.55 0.89 3.16 1.27 1.06 0.98 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 72 A 0.59 1.56 5.59 1.29 1.07 0.92 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 73 D 0.62 2.27 5.51 1.21 1.07 0.93 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 74 P 0.63 3.07 5.63 1.19 1.07 0.95 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 75 E 0.65 4.14 5.11 1.10 1.07 0.98 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 76 T 0.65 3.32 5.74 1.21 1.05 0.97 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 77 S 0.65 2.17 4.61 1.10 1.02 1.00 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 78 H 0.65 1.32 2.89 1.02 0.99 0.98 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 79 S 0.63 1.53 3.20 1.12 0.96 0.98 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 80 A 0.61 0.94 1.14 1.07 0.95 1.03 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 81 W 0.58 0.68 1.03 1.09 0.94 1.01 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 82 D 0.54 0.68 1.66 1.16 0.96 1.00 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 83 L 0.52 0.68 1.03 1.05 0.98 1.00 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 84 G 0.49 0.56 -0.59 1.04 0.99 1.01 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 85 S 0.46 0.29 -0.47 0.99 0.99 1.04 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 86 A 0.42 0.31 -3.21 0.86 0.97 1.07 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 87 F 0.40 0.41 -0.97 0.98 0.95 1.03 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 88 F 0.38 0.31 -0.97 0.98 0.96 1.03 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 89 F 0.35 0.44 -1.16 0.92 0.98 1.02 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 90 S 0.34 0.35 -2.60 0.89 1.01 1.03 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 91 G 0.34 0.29 -2.43 0.87 1.02 1.04 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 92 T 0.35 0.48 -0.37 0.92 1.01 1.01 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 93 I 0.37 0.51 1.69 0.97 0.99 0.99 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 94 I 0.39 0.36 -0.39 0.84 0.98 1.01 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 95 T 0.44 0.25 -0.39 0.84 0.99 1.01 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 96 T 0.48 0.56 -1.40 0.86 0.99 1.04 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 97 I 0.50 0.79 0.56 1.02 0.99 1.00 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 98 G 0.53 0.88 2.70 1.17 0.99 0.95 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 99 Y 0.56 0.45 1.43 1.11 0.98 1.02 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 100 G 0.57 0.65 0.99 1.06 0.98 1.04 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 101 N 0.60 0.54 0.81 1.08 0.97 1.05 132.12 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 102 V 0.58 0.68 0.60 0.99 0.96 1.05 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 103 A 0.58 0.99 1.61 0.97 0.96 1.02 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 104 L 0.57 1.03 2.23 0.95 0.98 1.02 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 105 R 0.55 1.40 1.53 0.83 1.01 1.06 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 106 T 0.54 1.37 2.87 0.98 1.04 0.99 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 107 D 0.52 3.25 3.17 1.02 1.05 0.96 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 108 A 0.49 1.37 3.17 1.02 1.05 0.96 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 109 G 0.47 0.82 1.26 0.97 1.03 0.99 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 110 R 0.42 0.26 0.71 1.00 1.00 1.06 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 111 L 0.39 0.18 -1.86 0.86 0.97 1.10 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 112 F 0.36 0.16 -3.47 0.85 0.94 1.11 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 113 C 0.32 0.13 -4.56 0.79 0.92 1.15 121.15 5.52 2.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 114 I 0.30 0.16 -4.86 0.75 0.90 1.17 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 115 F 0.28 0.15 -4.86 0.75 0.89 1.17 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 116 Y 0.26 0.21 -4.07 0.74 0.89 1.22 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 117 A 0.26 0.29 -3.46 0.79 0.89 1.14 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 118 L 0.27 0.24 -3.46 0.79 0.91 1.14 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 119 V 0.28 0.23 -1.84 0.92 0.92 1.14 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 120 G 0.29 0.19 -2.89 0.84 0.94 1.15 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 121 I 0.29 0.20 -4.50 0.83 0.95 1.15 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 122 P 0.31 0.27 -2.37 0.97 0.95 1.10 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 123 L 0.32 0.19 -2.99 0.97 0.94 1.07 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 124 F 0.32 0.22 -5.11 0.83 0.93 1.12 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 125 G 0.33 0.12 -5.29 0.85 0.92 1.13 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 126 I 0.34 0.15 -5.29 0.72 0.92 1.13 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 127 L 0.35 0.17 -3.16 0.86 0.92 1.08 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 128 L 0.37 0.12 -2.37 0.85 0.93 1.12 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 129 A 0.39 0.18 -2.37 0.85 0.94 1.12 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 130 G 0.43 0.36 0.20 0.99 0.96 1.08 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 131 V 0.44 0.85 2.11 1.04 0.98 1.03 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 132 G 0.46 0.69 2.11 1.04 1.00 1.03 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 133 D 0.47 0.69 2.63 1.17 1.01 1.00 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 134 R 0.48 1.25 2.74 1.15 1.03 1.02 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 135 L 0.49 1.69 4.20 1.28 1.04 0.97 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 136 G 0.50 0.83 2.07 1.14 1.05 1.02 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 137 S 0.51 0.83 1.24 1.07 1.05 1.02 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 138 S 0.50 1.37 0.94 1.07 1.03 1.05 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 139 L 0.50 1.37 3.07 1.21 1.00 1.00 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 140 R 0.49 0.72 1.11 1.05 0.97 1.04 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 141 H 0.50 0.53 1.00 1.07 0.96 1.02 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 142 G 0.51 0.88 0.37 1.00 0.95 1.03 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 143 I 0.52 0.31 0.54 0.99 0.95 1.02 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 144 G 0.53 0.40 1.06 0.96 0.94 1.02 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 145 H 0.53 0.41 1.06 0.92 0.94 1.01 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 146 I 0.53 0.41 -0.90 0.76 0.93 1.05 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 147 E 0.54 0.36 -1.07 0.78 0.92 1.04 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 148 A 0.55 0.22 -3.20 0.64 0.92 1.10 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 149 I 0.57 0.62 -2.69 0.65 0.93 1.07 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 150 F 0.59 0.37 -2.97 0.72 0.94 1.03 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 151 L 0.60 0.50 -3.79 0.75 0.95 1.07 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 152 K 0.61 0.53 -4.61 0.73 0.95 1.11 146.19 8.75 -3.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 153 W 0.62 0.95 -3.17 0.88 0.96 1.10 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 154 H 0.63 1.79 -1.56 1.01 0.96 1.10 155.16 6.74 -3.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 155 V 0.64 1.55 0.87 1.03 0.98 1.04 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 156 P 0.65 1.21 -1.26 0.97 1.00 1.09 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 157 P 0.66 0.66 -0.36 0.90 1.01 1.16 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 158 E 0.65 1.75 -0.06 0.90 1.00 1.12 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 159 L 0.64 0.84 -0.06 0.90 0.98 1.12 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 160 V 0.64 0.45 -1.67 0.77 0.95 1.15 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 161 R 0.63 0.35 -1.04 0.76 0.94 1.14 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 162 V 0.63 0.42 -1.86 0.75 0.93 1.17 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 163 L 0.62 0.57 -1.14 0.75 0.93 1.11 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 164 S 0.61 0.24 -1.93 0.76 0.92 1.09 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 165 A 0.60 0.28 -3.84 0.71 0.91 1.13 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 166 M 0.57 0.28 -4.63 0.72 0.90 1.11 149.21 5.28 1.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 167 L 0.56 0.17 -4.63 0.72 0.90 1.11 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 168 F 0.53 0.12 -6.70 0.59 0.90 1.13 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 169 L 0.49 0.12 -6.19 0.71 0.91 1.10 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 170 L 0.47 0.08 -5.39 0.80 0.91 1.18 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 171 I 0.43 0.07 -5.39 0.80 0.91 1.18 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 172 G 0.40 0.07 -5.39 0.80 0.91 1.21 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 173 C 0.36 0.08 -5.39 0.80 0.91 1.18 121.15 5.52 2.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 174 L 0.31 0.08 -4.60 0.79 0.91 1.20 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 175 L 0.28 0.07 -4.77 0.80 0.92 1.22 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 176 F 0.26 0.18 -4.84 0.72 0.93 1.22 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 177 V 0.26 0.34 -4.74 0.76 0.95 1.17 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 178 L 0.26 0.60 -2.69 0.82 0.98 1.12 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 179 T 0.26 0.60 -2.69 0.82 1.00 1.10 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 180 P 0.26 0.60 -1.90 0.80 1.01 1.14 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 181 T 0.27 0.63 -2.69 0.82 0.99 1.10 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 182 F 0.30 0.23 -1.17 0.90 0.97 1.12 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 183 V 0.34 0.24 -2.19 0.93 0.94 1.16 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 184 F 0.38 0.16 -3.09 0.80 0.91 1.12 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 185 C 0.42 0.33 -2.71 0.77 0.90 1.12 121.15 5.52 2.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 186 Y 0.45 0.73 0.03 0.89 0.91 1.08 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 187 M 0.48 0.89 -0.87 0.96 0.93 1.01 149.21 5.28 1.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 188 E 0.51 2.22 1.37 1.07 0.97 1.00 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 189 D 0.53 2.84 1.99 1.05 1.00 0.93 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 190 W 0.54 2.36 0.94 0.97 1.01 0.95 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 191 S 0.53 2.36 2.66 0.99 1.02 0.95 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 192 K 0.52 1.43 1.84 0.98 1.01 0.98 146.19 8.75 -3.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 193 L 0.47 0.95 -0.73 0.84 0.98 1.02 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 194 E 0.43 1.12 0.43 0.86 0.95 1.06 147.13 4.00 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 195 A 0.39 0.48 -1.81 0.74 0.93 1.07 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 196 I 0.35 0.43 -3.16 0.67 0.90 1.14 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 197 Y 0.32 0.19 -2.37 0.66 0.89 1.15 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 198 F 0.29 0.27 -2.74 0.69 0.90 1.16 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 199 V 0.26 0.31 -4.36 0.68 0.91 1.19 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 200 V 0.25 0.29 -2.47 0.75 0.93 1.16 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 201 T 0.24 0.48 -1.46 0.72 0.96 1.12 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 202 L 0.26 0.48 -0.67 0.71 0.98 1.16 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 203 T 0.28 0.64 0.67 0.86 1.00 1.09 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 204 T 0.32 0.38 -0.11 0.88 1.00 1.05 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 205 V 0.35 0.46 -0.04 0.96 0.99 1.04 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 206 G 0.37 0.53 2.70 1.09 0.98 0.99 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 207 F 0.40 0.58 1.69 1.11 0.98 1.02 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 208 G 0.43 0.58 0.41 1.05 0.99 1.09 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 209 D 0.46 0.59 1.24 1.07 0.99 1.04 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 210 Y 0.49 0.68 1.24 1.07 0.97 1.04 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 211 V 0.51 0.69 2.86 1.08 0.96 1.04 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 212 A 0.54 0.69 3.47 1.06 0.96 1.04 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 213 G 0.56 0.68 2.34 1.07 0.98 1.07 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 214 A 0.58 1.80 3.21 1.04 1.01 1.03 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 215 D 0.59 3.08 4.60 1.11 1.04 0.97 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 216 P 0.60 5.20 5.73 1.23 1.06 0.95 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 217 R 0.62 6.90 5.84 1.21 1.08 0.97 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 218 Q 0.64 6.39 5.84 1.33 1.09 0.97 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 219 D 0.64 4.17 4.71 1.22 1.09 0.99 133.10 3.80 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 220 S 0.63 3.34 4.14 1.16 1.08 1.01 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 221 P 0.61 3.34 4.40 1.17 1.05 1.03 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 222 A 0.58 3.09 3.84 1.24 1.02 1.04 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 223 Y 0.55 1.90 1.10 1.12 1.01 1.09 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 224 Q 0.52 0.91 -0.36 0.99 1.00 1.14 146.15 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 225 P 0.49 0.95 -2.09 0.91 0.98 1.12 115.13 5.96 -1.60 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 226 L 0.45 0.53 -3.70 0.90 0.96 1.12 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 227 V 0.40 0.32 -4.86 0.87 0.92 1.08 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 228 W 0.37 0.14 -6.86 0.80 0.89 1.10 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 229 F 0.33 0.14 -8.47 0.67 0.87 1.13 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 230 W 0.30 0.16 -8.47 0.67 0.87 1.13 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 231 I 0.28 0.15 -7.13 0.82 0.88 1.06 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 232 L 0.28 0.14 -7.01 0.77 0.91 1.11 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 233 L 0.29 0.14 -5.40 0.77 0.92 1.10 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 234 G 0.28 0.31 -4.24 0.80 0.92 1.14 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 235 L 0.27 0.32 -4.41 0.82 0.92 1.13 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 236 A 0.29 0.40 -2.80 0.83 0.91 1.11 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 237 Y 0.29 0.54 -0.56 0.95 0.90 1.07 181.19 5.52 -1.30 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 238 F 0.32 0.48 -1.90 0.80 0.91 1.15 165.19 5.52 2.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 239 A 0.34 0.40 -1.90 0.80 0.92 1.15 89.09 5.57 1.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 240 S 0.37 0.36 -1.46 0.84 0.93 1.12 105.09 5.24 -0.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 241 V 0.36 0.61 -0.44 0.81 0.96 1.09 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 242 L 0.35 0.42 -0.27 0.80 0.98 1.10 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 243 T 0.37 0.31 0.24 0.92 1.00 1.07 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 244 T 0.41 0.67 0.31 0.94 1.02 1.04 119.12 5.19 -0.70 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 245 I 0.40 0.86 -0.59 1.01 1.02 0.97 131.17 5.52 4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 246 G 0.43 0.49 -0.59 1.01 1.01 0.97 75.07 5.52 -0.40 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 247 N 0.44 0.67 -0.73 1.01 0.99 0.96 132.12 5.52 -3.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 248 W 0.43 0.71 -2.00 0.94 0.96 1.03 204.23 5.52 -0.90 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 249 L 0.37 0.53 -1.39 0.95 0.00 1.06 131.17 5.52 3.80 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 250 R 0.34 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 251 V 0.30 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 252 V 0.24 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 R 0.19 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 S 0.23 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 3 T 0.27 1.27 0.00 0.00 0.00 0.00 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 4 T 0.30 0.66 0.69 0.88 1.03 1.04 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 5 L 0.32 0.40 -1.23 0.83 0.99 1.09 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 6 L 0.32 0.23 -3.47 0.71 0.95 1.13 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 7 A 0.31 0.16 -3.91 0.66 0.93 1.15 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 8 L 0.30 0.16 -5.97 0.61 0.91 1.20 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 9 L 0.29 0.15 -5.19 0.60 0.91 1.22 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 10 A 0.29 0.12 -5.19 0.60 0.91 1.22 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 11 L 0.28 0.12 -6.80 0.59 0.91 1.24 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 12 V 0.26 0.23 -5.76 0.67 0.91 1.23 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 13 L 0.25 0.18 -5.76 0.67 0.91 1.23 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 14 L 0.27 0.17 -6.59 0.64 0.90 1.28 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 15 Y 0.28 0.30 -4.34 0.76 0.91 1.24 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 16 L 0.30 0.36 -3.00 0.91 0.93 1.17 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 17 V 0.32 0.44 -1.39 0.92 0.95 1.14 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 18 S 0.33 0.23 -1.39 0.92 0.97 1.14 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 19 G 0.31 0.21 -1.64 0.83 0.98 1.17 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 20 A 0.33 0.24 -1.64 0.83 0.96 1.15 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 21 L 0.36 0.36 -0.51 0.90 0.94 1.08 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 22 V 0.37 0.36 -1.14 0.79 0.93 1.09 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 23 F 0.38 0.30 -3.27 0.65 0.92 1.14 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 24 R 0.41 0.62 -2.46 0.66 0.93 1.11 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 25 A 0.44 1.45 -0.29 0.72 0.96 1.08 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 26 L 0.46 2.59 0.54 0.86 0.99 1.03 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 27 E 0.48 1.80 2.16 0.91 1.03 1.03 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 28 Q 0.53 3.09 2.67 0.88 1.06 1.03 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 29 P 0.54 6.48 3.23 0.93 1.07 1.02 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 30 H 0.55 6.48 5.40 0.98 1.06 0.99 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 31 E 0.59 3.78 4.59 0.97 1.06 1.02 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 32 Q 0.61 4.23 4.59 0.97 1.06 1.02 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 33 Q 0.61 6.09 4.89 0.89 1.05 0.99 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 34 A 0.59 6.09 5.70 0.86 1.05 0.95 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 35 Q 0.58 2.90 3.27 0.84 1.04 1.01 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 36 R 0.58 1.66 3.23 0.92 1.03 0.99 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 37 E 0.58 2.84 3.49 0.89 1.02 0.97 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 38 L 0.57 1.22 2.66 0.87 1.02 1.01 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 39 G 0.58 1.22 2.40 0.86 1.02 0.99 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 40 E 0.58 1.22 2.91 0.83 1.02 0.99 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 41 V 0.55 2.95 2.61 0.87 1.03 1.00 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 42 R 0.53 2.58 2.61 0.87 1.03 0.98 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 43 E 0.55 1.23 0.49 0.73 1.03 1.03 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 44 K 0.55 3.25 -0.03 0.76 1.01 1.04 146.19 8.75 -3.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 45 F 0.55 1.68 0.80 0.79 0.98 0.99 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 46 L 0.54 1.32 0.50 0.79 0.96 1.02 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 47 R 0.54 1.02 -0.31 0.90 0.94 1.05 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 48 A 0.53 0.63 -0.93 0.92 0.93 1.12 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 49 H 0.53 0.57 -0.14 0.91 0.93 1.16 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 50 P 0.56 0.39 2.10 1.03 0.93 1.13 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 51 C 0.57 0.64 2.93 1.10 0.94 1.13 121.15 5.52 2.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 52 V 0.58 0.82 3.49 1.15 0.97 1.12 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 53 S 0.57 0.91 4.30 1.12 1.01 1.09 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 54 D 0.58 1.41 2.69 0.98 1.03 1.11 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 55 Q 0.58 1.88 3.30 1.04 1.05 1.04 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 56 E 0.55 1.15 2.51 1.05 1.03 1.02 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 57 L 0.52 0.57 0.27 0.93 1.00 1.05 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 58 G 0.51 0.23 -2.30 0.79 0.97 1.09 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 59 L 0.49 0.27 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 60 L 0.46 0.56 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 61 I 0.43 0.42 -1.56 0.78 0.96 1.10 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 62 K 0.42 0.51 -2.07 0.65 0.98 1.13 146.19 8.75 -3.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 63 E 0.41 1.04 0.67 0.78 0.98 1.07 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 64 V 0.39 1.50 2.29 0.79 0.97 1.04 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 65 A 0.42 0.62 2.11 0.80 0.96 1.06 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 66 D 0.44 0.35 2.11 0.88 0.95 1.05 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 67 A 0.44 0.47 1.81 1.00 0.97 1.05 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 68 L 0.44 0.46 3.16 1.15 1.00 0.98 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 69 G 0.48 0.28 3.16 1.15 1.03 0.98 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 70 G 0.50 0.46 3.16 1.15 1.05 0.98 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 71 G 0.52 0.87 3.16 1.27 1.06 0.98 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 72 A 0.55 1.51 5.59 1.29 1.07 0.92 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 73 D 0.59 2.21 5.51 1.21 1.07 0.93 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 74 P 0.62 3.87 5.56 1.13 1.08 0.95 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 75 E 0.63 5.13 5.67 1.11 1.09 0.97 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 76 T 0.65 4.11 6.30 1.22 1.10 0.96 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 77 Q 0.68 3.62 5.17 1.14 1.11 1.00 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 78 S 0.68 2.80 5.80 1.13 1.09 0.99 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 79 S 0.68 1.96 4.99 1.12 1.05 1.02 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 80 H 0.67 1.19 2.81 1.12 1.01 1.02 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 81 S 0.65 1.48 3.39 1.19 0.97 0.99 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 82 A 0.63 0.91 1.14 1.07 0.95 1.03 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 83 W 0.61 0.66 1.03 1.09 0.94 1.01 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 84 D 0.59 0.66 1.66 1.16 0.96 1.00 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 85 L 0.55 0.66 1.03 1.05 0.98 1.00 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 86 G 0.54 0.55 -0.59 1.04 0.99 1.01 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 87 S 0.52 0.28 -0.47 0.99 0.99 1.04 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 88 A 0.48 0.30 -3.21 0.86 0.97 1.07 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 89 F 0.46 0.40 -0.97 0.98 0.95 1.03 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 90 F 0.43 0.30 -0.97 0.98 0.96 1.03 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 91 F 0.40 0.43 -1.16 0.92 0.98 1.02 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 92 S 0.37 0.34 -2.60 0.89 1.01 1.03 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 93 G 0.35 0.28 -2.43 0.87 1.02 1.04 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 94 T 0.36 0.46 -0.37 0.92 1.01 1.01 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 95 I 0.35 0.50 1.69 0.97 0.99 0.99 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 96 I 0.36 0.35 -0.39 0.84 0.98 1.01 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 97 T 0.38 0.24 -0.39 0.84 0.99 1.01 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 98 T 0.41 0.54 -1.40 0.86 0.99 1.04 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 99 I 0.44 0.77 0.56 1.02 0.99 1.00 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 100 G 0.48 0.85 2.70 1.17 0.99 0.95 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 101 Y 0.52 0.44 1.43 1.11 0.98 1.02 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 102 G 0.57 0.63 0.99 1.06 0.98 1.04 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 103 N 0.60 0.53 0.81 1.08 0.97 1.05 132.12 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 104 V 0.60 0.66 0.60 0.99 0.96 1.05 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 105 A 0.62 0.96 1.61 0.97 0.96 1.02 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 106 L 0.62 1.00 2.23 0.95 0.98 1.02 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 107 R 0.62 1.36 1.53 0.83 1.01 1.06 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 108 T 0.62 1.33 2.87 0.98 1.04 0.99 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 109 D 0.60 3.16 3.17 1.02 1.05 0.96 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 110 A 0.58 1.33 3.17 1.02 1.05 0.96 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 111 G 0.54 0.80 1.26 0.97 1.03 0.99 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 112 R 0.50 0.26 0.71 1.00 1.00 1.06 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 113 L 0.46 0.18 -1.86 0.86 0.97 1.10 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 114 F 0.43 0.16 -3.47 0.85 0.94 1.11 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 115 C 0.39 0.12 -4.56 0.79 0.92 1.15 121.15 5.52 2.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 116 I 0.35 0.15 -4.86 0.75 0.90 1.17 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 117 F 0.32 0.15 -4.86 0.75 0.89 1.17 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 118 Y 0.29 0.20 -4.07 0.74 0.89 1.22 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 119 A 0.28 0.28 -3.46 0.79 0.89 1.14 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 120 L 0.28 0.23 -3.46 0.79 0.91 1.14 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 121 V 0.29 0.23 -1.84 0.92 0.92 1.14 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 122 G 0.30 0.19 -2.89 0.84 0.94 1.15 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 123 I 0.30 0.19 -4.50 0.83 0.95 1.15 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 124 P 0.31 0.26 -2.37 0.97 0.95 1.10 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 125 L 0.32 0.18 -2.99 0.97 0.94 1.07 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 126 F 0.33 0.22 -5.11 0.83 0.93 1.12 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 127 G 0.34 0.12 -5.29 0.85 0.92 1.13 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 128 I 0.35 0.14 -5.29 0.72 0.92 1.13 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 129 L 0.36 0.16 -3.16 0.86 0.92 1.08 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 130 L 0.38 0.12 -2.37 0.85 0.93 1.12 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 131 A 0.40 0.17 -2.37 0.85 0.94 1.12 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 132 G 0.44 0.35 0.20 0.99 0.96 1.08 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 133 V 0.46 0.82 2.11 1.04 0.98 1.03 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 134 G 0.48 0.67 2.11 1.04 1.00 1.03 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 135 D 0.50 0.67 2.63 1.17 1.01 1.00 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 136 R 0.52 1.21 2.74 1.15 1.03 1.02 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 137 L 0.54 1.64 4.20 1.28 1.04 0.97 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 138 G 0.55 0.81 2.07 1.14 1.05 1.02 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 139 S 0.56 0.81 1.24 1.07 1.05 1.02 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 140 S 0.56 1.34 0.94 1.07 1.03 1.05 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 141 L 0.55 1.34 3.07 1.21 1.00 1.00 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 142 R 0.54 0.70 1.11 1.05 0.97 1.04 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 143 H 0.55 0.52 1.00 1.07 0.96 1.02 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 144 G 0.55 0.85 0.37 1.00 0.95 1.03 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 145 I 0.56 0.31 0.54 0.99 0.95 1.02 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 146 G 0.56 0.39 1.06 0.96 0.94 1.02 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 147 H 0.57 0.40 1.06 0.92 0.94 1.01 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 148 I 0.59 0.40 -0.90 0.76 0.93 1.05 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 149 E 0.59 0.35 -1.07 0.78 0.92 1.04 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 150 A 0.60 0.21 -3.20 0.64 0.92 1.10 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 151 I 0.62 0.60 -2.69 0.65 0.93 1.07 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 152 F 0.63 0.36 -2.97 0.72 0.94 1.03 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 153 L 0.64 0.49 -3.79 0.75 0.95 1.07 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 154 K 0.64 0.52 -4.61 0.73 0.95 1.11 146.19 8.75 -3.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 155 W 0.64 0.93 -3.17 0.88 0.96 1.10 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 156 H 0.64 1.74 -1.56 1.01 0.96 1.10 155.16 6.74 -3.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 157 V 0.64 1.51 0.87 1.03 0.98 1.04 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 158 P 0.65 1.18 -1.26 0.97 1.00 1.09 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 159 P 0.67 0.64 -0.36 0.90 1.01 1.16 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 160 E 0.65 1.70 -0.06 0.90 1.00 1.12 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 161 L 0.65 0.82 -0.06 0.90 0.98 1.12 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 162 V 0.63 0.44 -1.67 0.77 0.95 1.15 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 163 R 0.62 0.34 -1.04 0.76 0.94 1.14 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 164 V 0.60 0.41 -1.86 0.75 0.93 1.17 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 165 L 0.58 0.55 -1.14 0.75 0.93 1.11 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 166 S 0.56 0.23 -1.93 0.76 0.92 1.09 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 167 A 0.55 0.27 -3.84 0.71 0.91 1.13 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 168 M 0.52 0.27 -4.63 0.72 0.90 1.11 149.21 5.28 1.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 169 L 0.53 0.17 -4.63 0.72 0.90 1.11 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 170 F 0.53 0.12 -6.70 0.59 0.90 1.13 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 171 L 0.53 0.12 -6.19 0.71 0.91 1.10 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 172 L 0.55 0.07 -5.39 0.80 0.91 1.18 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 173 I 0.56 0.07 -5.39 0.80 0.91 1.18 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 174 G 0.56 0.07 -5.39 0.80 0.91 1.21 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 175 C 0.55 0.07 -5.39 0.80 0.91 1.18 121.15 5.52 2.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 176 L 0.52 0.08 -4.60 0.79 0.91 1.20 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 177 L 0.49 0.07 -4.77 0.80 0.92 1.22 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 178 F 0.45 0.18 -4.84 0.72 0.93 1.22 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 179 V 0.43 0.33 -4.74 0.76 0.95 1.17 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 180 L 0.41 0.58 -2.69 0.82 0.98 1.12 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 181 T 0.39 0.58 -2.69 0.82 1.00 1.10 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 182 P 0.39 0.58 -1.90 0.80 1.01 1.14 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 183 T 0.39 0.61 -2.69 0.82 0.99 1.10 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 184 F 0.41 0.23 -1.17 0.90 0.97 1.12 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 185 V 0.44 0.23 -2.19 0.93 0.94 1.16 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 186 F 0.47 0.16 -3.09 0.80 0.91 1.12 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 187 C 0.50 0.32 -2.71 0.77 0.90 1.12 121.15 5.52 2.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 188 Y 0.52 0.71 0.03 0.89 0.91 1.08 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 189 M 0.54 0.87 -0.87 0.96 0.93 1.01 149.21 5.28 1.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 190 E 0.54 2.16 1.37 1.07 0.97 1.00 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 191 D 0.53 2.76 1.99 1.05 1.00 0.93 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 192 W 0.53 2.30 0.94 0.97 1.01 0.95 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 193 S 0.51 2.30 2.66 0.99 1.02 0.95 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 194 K 0.48 1.39 1.84 0.98 1.01 0.98 146.19 8.75 -3.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 195 L 0.45 0.93 -0.73 0.84 0.98 1.02 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 196 E 0.41 1.08 0.43 0.86 0.95 1.06 147.13 4.00 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 197 A 0.37 0.47 -1.81 0.74 0.93 1.07 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 198 I 0.34 0.42 -3.16 0.67 0.90 1.14 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 199 Y 0.30 0.17 -2.99 0.65 0.89 1.12 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 200 F 0.28 0.13 -4.63 0.62 0.89 1.20 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 201 V 0.25 0.26 -4.19 0.66 0.90 1.18 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 202 I 0.26 0.14 -4.36 0.68 0.91 1.19 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 203 V 0.26 0.23 -3.34 0.65 0.93 1.15 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 204 T 0.27 0.44 -1.29 0.71 0.95 1.13 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 205 L 0.29 0.47 -1.29 0.71 0.98 1.13 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 206 T 0.32 0.62 0.67 0.86 1.00 1.09 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 207 T 0.36 0.37 -0.11 0.88 1.00 1.05 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 208 V 0.39 0.45 -0.04 0.96 0.99 1.04 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 209 G 0.42 0.52 2.70 1.09 0.98 0.99 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 210 F 0.45 0.56 1.69 1.11 0.98 1.02 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 211 G 0.46 0.56 0.41 1.05 0.99 1.09 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 212 D 0.48 0.58 1.24 1.07 0.99 1.04 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 213 Y 0.49 0.66 1.24 1.07 0.97 1.04 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 214 V 0.51 0.67 2.86 1.08 0.96 1.04 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 215 A 0.54 0.67 3.47 1.06 0.96 1.04 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 216 G 0.56 0.66 2.34 1.07 0.98 1.07 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 217 A 0.58 1.75 3.21 1.04 1.01 1.03 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 218 D 0.59 3.00 4.60 1.11 1.04 0.97 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 219 P 0.60 5.06 5.73 1.23 1.06 0.95 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 220 R 0.63 6.71 5.84 1.21 1.08 0.97 174.20 9.75 -4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 221 Q 0.64 6.21 5.84 1.33 1.09 0.97 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 222 D 0.64 4.06 4.71 1.22 1.09 0.99 133.10 3.80 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 223 S 0.63 3.25 4.14 1.16 1.08 1.01 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 224 P 0.60 3.25 4.40 1.17 1.05 1.03 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 225 A 0.57 3.01 3.84 1.24 1.02 1.04 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 226 Y 0.54 1.85 1.10 1.12 1.01 1.09 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 227 Q 0.51 0.89 -0.36 0.99 1.00 1.14 146.15 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 228 P 0.48 0.92 -2.09 0.91 0.98 1.12 115.13 5.96 -1.60 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 229 L 0.44 0.51 -3.70 0.90 0.96 1.12 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 230 V 0.40 0.31 -4.86 0.87 0.92 1.08 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 231 W 0.37 0.14 -6.86 0.80 0.89 1.10 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 232 F 0.34 0.14 -8.47 0.67 0.87 1.13 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 233 W 0.31 0.16 -8.47 0.67 0.87 1.13 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 234 I 0.29 0.15 -7.13 0.82 0.88 1.06 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 235 L 0.29 0.14 -7.01 0.77 0.91 1.11 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 236 L 0.30 0.13 -5.40 0.77 0.92 1.10 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 237 G 0.29 0.30 -4.24 0.80 0.92 1.14 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 238 L 0.28 0.32 -4.41 0.82 0.92 1.13 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 239 A 0.29 0.39 -2.80 0.83 0.91 1.11 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 240 Y 0.29 0.52 -0.56 0.95 0.90 1.07 181.19 5.52 -1.30 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 241 F 0.30 0.47 -1.90 0.80 0.91 1.15 165.19 5.52 2.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 242 A 0.33 0.38 -1.90 0.80 0.92 1.15 89.09 5.57 1.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 243 S 0.35 0.35 -1.46 0.84 0.93 1.12 105.09 5.24 -0.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 244 V 0.35 0.59 -0.44 0.81 0.96 1.09 117.15 5.49 4.20 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 245 L 0.34 0.41 -0.27 0.80 0.98 1.10 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 246 T 0.36 0.30 0.24 0.92 1.00 1.07 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 247 T 0.39 0.66 0.31 0.94 1.02 1.04 119.12 5.19 -0.70 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 248 I 0.40 0.84 -0.59 1.01 1.02 0.97 131.17 5.52 4.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 249 G 0.41 0.48 -0.59 1.01 1.01 0.97 75.07 5.52 -0.40 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 250 N 0.37 0.65 -0.73 1.01 0.00 0.96 132.12 5.52 -3.50 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 251 W 0.33 0.00 0.00 0.00 0.00 0.00 204.23 5.52 -0.90 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 252 L 0.28 0.00 0.00 0.00 0.00 0.00 131.17 5.52 3.80 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 253 R 0.24 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 1 C 0.24 0.00 0.00 0.00 0.00 0.00 121.15 5.52 2.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 2 D 0.29 0.00 0.00 0.00 0.00 0.00 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 3 A 0.34 0.12 0.00 0.00 0.00 0.00 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 4 F 0.40 0.32 1.64 0.99 0.95 1.09 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 5 V 0.45 0.20 0.01 0.96 0.96 1.01 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 6 G 0.47 0.40 -0.60 0.89 0.99 1.02 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 7 T 0.49 0.38 -2.21 0.88 1.00 1.05 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 8 W 0.50 0.38 -1.43 0.87 0.99 1.09 204.23 5.52 -0.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 9 K 0.52 0.52 0.03 1.00 1.00 1.04 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 10 L 0.53 0.48 0.14 0.98 1.00 1.06 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 11 V 0.55 0.79 0.51 0.95 1.01 1.05 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 12 S 0.56 0.64 2.94 1.04 1.04 1.03 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 13 S 0.57 0.67 0.81 0.98 1.05 1.05 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 14 E 0.58 1.51 3.56 1.10 1.05 1.00 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 15 N 0.58 1.88 5.51 1.24 1.05 0.92 132.12 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 16 F 0.55 2.20 4.31 1.20 1.03 0.95 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 17 D 0.55 1.26 2.79 1.08 1.02 0.92 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 18 D 0.55 1.56 2.49 1.12 1.01 0.93 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 19 Y 0.54 3.13 2.60 1.00 0.99 0.94 181.19 5.52 -1.30 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 20 M 0.53 1.39 3.39 0.99 0.99 0.98 149.21 5.28 1.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 21 K 0.53 0.82 2.77 1.00 0.99 0.98 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 22 E 0.52 0.39 0.81 0.86 0.99 1.06 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 23 V 0.53 0.39 1.90 0.92 0.98 1.02 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 24 G 0.54 0.17 1.19 0.92 0.97 1.06 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 25 V 0.55 0.10 0.67 0.87 0.95 1.07 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 26 G 0.55 0.19 0.30 0.91 0.95 1.08 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 27 F 0.54 0.38 1.43 0.97 0.96 1.01 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 28 A 0.54 1.02 1.43 0.89 0.98 1.02 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 29 T 0.52 0.77 1.43 0.89 1.00 1.02 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 30 R 0.53 0.89 0.91 0.76 1.01 1.04 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 31 K 0.52 0.88 3.04 0.90 1.01 1.01 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 32 V 0.51 0.60 2.14 0.89 0.98 0.98 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 33 A 0.51 0.31 1.70 0.85 0.95 1.00 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 34 G 0.51 0.31 1.91 0.86 0.94 1.01 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 35 M 0.50 0.65 1.40 0.93 0.94 1.03 149.21 5.28 1.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 36 A 0.48 1.03 2.93 1.08 0.97 0.94 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 37 K 0.47 1.03 2.03 1.07 0.99 0.91 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 38 P 0.46 0.73 0.07 0.92 0.99 0.95 115.13 5.96 -1.60 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 39 N 0.45 0.50 -0.47 0.90 0.97 0.99 132.12 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 40 M 0.45 0.34 0.16 1.01 0.94 0.99 149.21 5.28 1.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 41 I 0.45 0.16 -1.19 0.94 0.92 1.05 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 42 I 0.45 0.16 -0.49 0.94 0.92 1.01 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 43 S 0.46 0.16 -0.67 0.94 0.94 1.02 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 44 V 0.47 0.39 1.36 1.06 0.98 1.03 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 45 N 0.47 0.46 1.19 1.08 1.02 1.04 132.12 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 46 G 0.47 0.25 1.80 1.09 1.04 1.08 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 47 D 0.47 0.49 1.61 1.02 1.03 1.06 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 48 L 0.47 0.21 1.00 1.01 1.00 1.03 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 49 V 0.46 0.42 0.60 0.93 0.98 1.04 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 50 T 0.46 0.34 0.71 0.91 0.98 1.06 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 51 I 0.45 0.71 0.40 0.81 1.01 1.06 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 52 R 0.45 1.29 2.64 0.93 1.05 1.03 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 53 S 0.45 1.29 3.91 0.99 1.09 0.96 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 54 E 0.47 1.59 1.86 0.94 1.09 0.99 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 55 S 0.49 1.62 3.81 1.02 1.09 0.95 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 56 T 0.50 1.95 4.21 1.10 1.07 0.94 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 57 F 0.51 1.62 4.03 1.04 1.05 0.93 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 58 K 0.51 2.10 4.03 1.04 1.06 0.93 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 59 N 0.50 1.02 1.96 0.90 1.06 0.95 132.12 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 60 T 0.49 1.58 2.14 0.97 1.05 0.96 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 61 E 0.48 0.68 2.14 0.97 1.03 0.96 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 62 I 0.47 0.85 2.14 0.97 1.00 0.96 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 63 S 0.46 0.49 -0.17 0.83 0.98 1.03 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 64 F 0.45 0.28 -0.10 0.91 0.97 1.02 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 65 K 0.46 0.29 -1.74 0.88 0.97 1.10 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 66 L 0.46 0.38 0.51 0.92 0.97 1.06 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 67 G 0.47 0.38 -1.73 0.80 0.96 1.07 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 68 V 0.49 0.32 1.01 0.92 0.96 1.04 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 69 E 0.52 0.67 1.31 0.88 0.97 1.02 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 70 F 0.53 0.47 1.49 0.87 0.98 1.01 165.19 5.52 2.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 71 D 0.54 0.92 1.41 0.78 1.00 1.01 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 72 E 0.56 0.53 2.24 0.80 1.01 0.97 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 73 I 0.57 1.03 2.56 0.91 1.01 0.97 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 74 T 0.58 1.03 5.30 1.03 1.01 0.94 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 75 A 0.59 1.17 4.47 0.96 1.02 0.94 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 76 D 0.58 3.33 4.17 1.00 1.04 0.95 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 77 D 0.56 1.71 4.79 1.00 1.04 0.98 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 78 R 0.54 3.39 4.86 1.01 1.05 0.99 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 79 K 0.52 2.72 5.49 1.12 1.05 0.98 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 80 V 0.49 1.14 2.91 0.98 1.03 1.02 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 81 K 0.48 0.41 0.34 0.83 1.02 1.06 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 82 S 0.46 0.29 0.49 0.84 0.99 1.07 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 83 I 0.43 0.33 -1.64 0.78 0.96 1.11 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 84 I 0.42 0.27 0.31 0.91 0.95 1.04 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 85 T 0.43 0.20 0.31 0.99 0.97 1.03 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 86 L 0.43 0.28 0.20 1.01 1.00 1.01 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 87 D 0.43 0.41 1.64 1.04 1.03 1.00 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 88 G 0.44 0.23 1.47 1.05 1.04 1.01 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 89 G 0.46 0.21 0.20 0.99 1.02 1.08 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 90 A 0.46 0.22 2.37 1.04 0.99 1.05 89.09 5.57 1.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 91 L 0.47 0.16 0.41 0.91 0.96 1.12 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 92 V 0.49 0.29 0.46 0.82 0.94 1.14 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 93 Q 0.50 0.57 0.46 0.75 0.95 1.15 146.15 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 94 V 0.52 0.73 -1.27 0.79 0.97 1.12 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 95 Q 0.53 1.63 1.47 0.91 1.00 1.07 146.15 5.52 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 96 K 0.54 0.93 2.81 1.06 1.02 1.00 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 97 W 0.55 2.51 2.77 1.07 1.04 0.98 204.23 5.52 -0.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 98 D 0.55 1.94 4.23 1.20 1.07 0.93 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 99 G 0.56 1.40 4.11 1.20 1.09 0.92 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 100 K 0.55 1.93 4.04 1.19 1.10 0.91 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 101 S 0.55 0.81 4.33 1.12 1.10 0.95 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 102 T 0.54 1.63 3.71 1.06 1.09 0.96 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 103 T 0.53 1.60 3.50 0.97 1.07 0.96 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 104 I 0.52 2.39 3.50 0.97 1.06 0.96 131.17 5.52 4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 105 K 0.52 3.24 3.17 0.90 1.05 0.94 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 106 R 0.51 3.75 3.86 0.97 1.05 0.93 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 107 K 0.51 5.29 3.93 1.06 1.06 0.93 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 108 R 0.51 4.42 6.50 1.20 1.06 0.89 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 109 D 0.50 4.51 6.50 1.20 1.07 0.89 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 110 G 0.49 1.86 4.59 1.15 1.07 0.94 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 111 D 0.47 0.71 3.24 1.08 1.05 1.01 133.10 3.80 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 112 K 0.46 0.31 2.11 1.01 1.02 1.08 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 113 L 0.44 0.55 1.80 0.91 0.99 1.08 131.17 5.52 3.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 114 V 0.43 0.18 1.19 0.86 0.95 1.15 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 115 V 0.43 0.07 -0.77 0.72 0.93 1.23 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 116 E 0.43 0.08 -2.19 0.66 0.91 1.21 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 117 C 0.42 0.21 -0.06 0.72 0.91 1.17 121.15 5.52 2.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 118 V 0.41 0.28 1.29 0.87 0.93 1.09 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 119 M 0.42 0.12 1.29 0.87 0.95 1.09 149.21 5.28 1.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 120 K 0.42 0.33 0.91 0.90 0.98 1.10 146.19 8.75 -3.90 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 121 G 0.43 0.59 1.64 0.94 1.02 1.05 75.07 5.52 -0.40 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 122 V 0.45 0.86 2.91 1.00 1.04 0.98 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 123 T 0.44 0.84 4.11 1.05 1.06 0.98 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 124 S 0.44 0.63 2.77 0.98 1.06 1.05 105.09 5.24 -0.80 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 125 T 0.44 1.33 1.69 0.92 1.05 1.09 119.12 5.19 -0.70 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 126 R 0.45 1.59 3.33 0.95 1.02 1.01 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 127 V 0.45 2.33 3.19 0.95 1.00 1.01 117.15 5.49 4.20 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 128 Y 0.40 1.63 2.56 0.84 0.00 1.02 181.19 5.52 -1.30 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 129 E 0.35 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 130 R 0.31 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 131 A 0.25 0.00 0.00 0.00 0.00 0.00 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 1 L 0.26 0.00 0.00 0.00 0.00 0.00 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 2 G 0.31 0.00 0.00 0.00 0.00 0.00 75.07 5.52 -0.40 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 3 S 0.37 1.28 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 4 R 0.43 1.28 1.06 1.00 1.06 1.01 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 5 R 0.48 1.28 1.77 1.01 1.03 0.95 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 6 T 0.46 0.79 -0.36 0.87 1.00 1.00 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 7 L 0.47 0.33 -2.60 0.75 0.96 1.03 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 8 M 0.47 0.17 -2.90 0.71 0.92 1.06 149.21 5.28 1.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 9 L 0.44 0.21 -2.64 0.71 0.91 1.08 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 10 L 0.46 0.25 -3.99 0.66 0.91 1.07 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 11 A 0.47 0.49 -2.07 0.71 0.92 1.01 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 12 Q 0.48 1.18 -0.66 0.77 0.94 1.03 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 13 M 0.49 1.01 -0.49 0.75 0.97 1.02 149.21 5.28 1.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 14 R 0.51 1.33 1.76 0.87 0.99 0.98 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 15 K 0.54 0.64 0.14 0.86 1.00 1.01 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 16 I 0.55 0.56 -2.03 0.81 0.99 1.02 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 17 S 0.55 0.38 -0.50 0.93 0.97 1.05 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 18 L 0.59 0.10 -0.90 0.96 0.95 1.12 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 19 F 0.58 0.12 -3.03 0.90 0.93 1.17 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 20 S 0.57 0.18 -1.07 0.98 0.93 1.14 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 21 C 0.57 0.36 -0.57 0.98 0.95 1.12 121.15 5.52 2.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 22 L 0.58 0.82 1.34 1.03 0.97 1.06 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 23 K 0.58 0.83 2.96 1.08 1.00 1.06 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 24 D 0.56 2.59 3.46 1.09 1.01 1.04 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 25 R 0.57 2.72 1.94 1.00 1.00 1.00 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 26 H 0.57 1.35 4.07 1.14 0.98 0.94 155.16 6.74 -3.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 27 D 0.56 0.70 1.94 1.08 0.96 0.97 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 28 F 0.55 0.55 0.81 1.09 0.95 0.99 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 29 G 0.55 0.70 1.07 1.10 0.97 1.02 75.07 5.52 -0.40 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 30 F 0.54 0.73 1.89 1.07 1.00 0.98 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 31 P 0.53 1.46 1.57 0.96 1.04 0.98 115.13 5.96 -1.60 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 32 Q 0.54 1.27 1.57 0.96 1.06 0.98 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 33 E 0.55 1.46 1.57 0.96 1.06 0.98 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 34 E 0.56 1.52 3.89 1.10 1.05 0.93 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 35 F 0.58 1.52 4.44 1.02 1.04 0.92 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 36 G 0.60 0.76 2.27 0.97 1.03 0.94 75.07 5.52 -0.40 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 37 N 0.60 0.76 2.01 1.00 1.03 0.96 132.12 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 38 Q 0.61 1.75 1.71 1.04 1.03 0.97 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 39 F 0.61 1.79 3.33 1.05 1.02 0.97 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 40 Q 0.60 1.92 3.63 0.93 1.03 0.96 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 41 K 0.57 1.60 3.37 0.85 1.03 0.98 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 42 A 0.55 1.30 1.37 0.77 1.04 1.00 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 43 E 0.51 1.16 2.99 0.91 1.03 1.00 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 44 T 0.46 0.43 1.60 0.84 1.02 1.05 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 45 I 0.44 0.35 -0.53 0.78 0.99 1.10 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 46 P 0.41 0.28 -0.53 0.82 0.97 1.10 115.13 5.96 -1.60 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 47 V 0.38 0.33 -0.53 0.82 0.95 1.10 117.15 5.49 4.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 48 L 0.35 0.47 -1.87 0.77 0.93 1.09 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 49 H 0.34 0.21 -1.87 0.77 0.92 1.09 155.16 6.74 -3.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 50 E 0.35 0.49 -1.31 0.69 0.92 1.08 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 51 M 0.34 1.04 0.07 0.76 0.93 1.03 149.21 5.28 1.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 52 I 0.36 0.53 0.24 0.74 0.94 1.02 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 53 Q 0.39 0.27 -1.37 0.69 0.95 1.01 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 54 Q 0.38 0.43 -1.49 0.81 0.95 1.00 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 55 I 0.38 0.51 -2.20 0.81 0.95 1.06 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 56 F 0.41 0.26 -2.37 0.83 0.94 1.06 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 57 N 0.44 0.20 -2.30 0.89 0.94 1.06 132.12 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 58 L 0.46 0.41 -2.41 0.89 0.95 1.04 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 59 F 0.49 0.94 -0.46 0.96 0.98 1.01 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 60 S 0.54 0.98 2.29 1.09 1.01 0.98 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 61 T 0.56 1.59 2.21 1.07 1.05 1.01 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 62 K 0.58 2.46 4.46 1.19 1.07 0.98 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 63 D 0.60 1.85 6.07 1.20 1.07 0.97 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 64 S 0.62 1.30 5.44 1.09 1.06 0.98 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 65 S 0.62 0.68 3.27 1.09 1.02 0.98 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 66 A 0.63 0.68 3.89 1.15 0.99 0.97 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 67 A 0.62 0.88 3.57 1.05 0.98 0.97 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 68 W 0.59 0.95 3.39 0.98 0.99 0.95 204.23 5.52 -0.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 69 D 0.56 0.77 1.14 0.86 1.01 0.99 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 70 E 0.53 0.63 -0.47 0.85 1.03 1.01 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 71 T 0.52 1.00 0.66 0.97 1.03 0.98 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 72 L 0.48 1.20 2.90 0.97 1.03 0.99 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 73 L 0.48 0.60 0.16 0.85 1.02 1.02 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 74 D 0.47 0.65 -1.23 0.91 1.01 1.07 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 75 K 0.45 1.14 -1.23 0.91 1.01 1.07 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 76 F 0.42 2.40 1.20 0.93 1.00 1.01 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 77 Y 0.43 1.18 1.20 0.93 0.99 1.01 181.19 5.52 -1.30 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 78 T 0.44 0.93 -0.50 0.88 0.99 1.05 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 79 E 0.44 1.85 -0.46 0.88 0.99 1.06 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 80 L 0.43 2.05 1.71 0.93 0.99 1.05 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 81 Y 0.46 1.17 0.67 0.85 0.99 1.06 181.19 5.52 -1.30 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 82 Q 0.47 1.09 0.93 0.94 0.99 1.05 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 83 Q 0.46 2.20 1.24 1.04 1.00 1.05 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 84 L 0.48 1.16 1.24 1.04 1.01 1.05 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 85 N 0.51 1.16 2.63 0.99 1.01 1.00 132.12 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 86 D 0.48 0.68 2.07 0.94 1.00 1.01 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 87 L 0.48 0.44 1.41 0.97 0.98 1.07 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 88 E 0.48 0.20 2.20 0.96 0.96 1.09 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 89 A 0.50 0.09 0.06 0.80 0.94 1.14 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 90 C 0.50 0.18 -0.51 0.73 0.93 1.16 121.15 5.52 2.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 91 V 0.51 0.10 1.61 0.87 0.94 1.11 117.15 5.49 4.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 92 I 0.54 0.10 -0.10 0.85 0.95 1.10 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 93 Q 0.53 0.37 0.41 0.90 0.98 1.08 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 94 G 0.54 0.87 1.33 0.84 1.00 1.00 75.07 5.52 -0.40 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 95 M 0.56 2.08 3.29 0.97 1.02 0.93 149.21 5.28 1.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 96 K 0.57 1.61 5.36 1.11 1.04 0.91 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 97 E 0.57 1.14 3.36 1.04 1.04 0.93 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 98 D 0.56 0.95 1.23 0.90 1.02 0.98 133.10 3.80 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 99 S 0.53 0.48 2.13 0.91 1.00 1.02 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 100 I 0.52 0.21 0.79 0.84 0.96 1.08 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 101 L 0.53 0.24 0.27 0.87 0.94 1.09 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 102 A 0.51 0.36 -0.34 0.80 0.94 1.09 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 103 V 0.49 0.80 -1.54 0.76 0.96 1.12 117.15 5.49 4.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 104 R 0.48 0.84 -1.71 0.78 0.98 1.11 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 105 K 0.48 1.45 0.46 0.83 0.99 1.07 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 106 Y 0.46 3.82 0.76 0.88 0.99 1.05 181.19 5.52 -1.30 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 107 F 0.46 1.37 0.14 0.87 0.99 1.01 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 108 Q 0.49 0.99 0.29 0.87 0.99 1.02 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 109 R 0.48 0.52 -1.84 0.81 0.99 1.06 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 110 I 0.44 0.94 -1.84 0.81 0.98 1.06 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 111 T 0.44 0.45 -1.84 0.81 0.96 1.09 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 112 L 0.47 0.46 -1.89 0.82 0.95 1.08 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 113 Y 0.48 1.13 -1.37 0.79 0.95 1.07 181.19 5.52 -1.30 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 114 L 0.47 1.56 0.59 0.86 0.98 1.04 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 115 K 0.50 3.79 0.66 0.87 1.02 1.04 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 116 E 0.49 3.79 1.70 0.95 1.05 1.03 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 117 K 0.48 6.16 2.90 0.99 1.06 1.01 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 118 K 0.48 4.76 4.51 1.12 1.06 0.98 146.19 8.75 -3.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 119 Y 0.49 1.47 3.90 1.15 1.04 1.05 181.19 5.52 -1.30 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 120 S 0.48 0.74 3.09 1.14 1.01 1.08 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 121 P 0.46 0.39 0.84 1.13 0.99 1.08 115.13 5.96 -1.60 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 122 C 0.45 0.43 1.14 1.09 0.95 1.07 121.15 5.52 2.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 123 A 0.41 0.24 0.89 1.00 0.94 1.10 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 124 W 0.40 0.11 -0.57 0.87 0.92 1.15 204.23 5.52 -0.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 125 E 0.39 0.42 -0.27 0.79 0.92 1.12 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 126 V 0.38 0.42 -0.17 0.71 0.93 1.07 117.15 5.49 4.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 127 V 0.36 0.69 0.64 0.72 0.94 1.04 117.15 5.49 4.20 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 128 R 0.39 0.28 0.93 0.65 0.94 1.08 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 129 A 0.40 0.37 -0.79 0.63 0.94 1.08 89.09 5.57 1.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 130 E 0.39 0.99 0.34 0.70 0.94 1.00 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 131 I 0.37 0.67 1.80 0.83 0.94 0.95 131.17 5.52 4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 132 M 0.40 0.58 -0.11 0.78 0.95 0.98 149.21 5.28 1.90 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 133 R 0.41 0.45 0.51 0.89 0.96 0.97 174.20 9.75 -4.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 134 S 0.41 0.53 -1.91 0.87 0.97 1.03 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 135 F 0.42 0.71 0.16 1.00 0.97 1.01 165.19 5.52 2.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 136 S 0.45 0.52 1.50 1.06 0.98 1.02 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 137 L 0.43 0.63 1.90 1.14 0.99 1.01 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 138 S 0.43 0.60 -0.34 1.02 1.00 1.04 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 139 T 0.45 0.78 1.83 1.08 1.02 1.03 119.12 5.19 -0.70 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 140 N 0.47 1.63 2.01 0.98 1.02 1.01 132.12 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 141 L 0.45 1.63 4.26 1.10 1.02 0.97 131.17 5.52 3.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 142 Q 0.39 0.93 2.01 0.98 0.00 1.01 146.15 5.52 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 143 E 0.36 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 144 S 0.29 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 145 L 0.24 0.00 0.00 0.00 0.00 0.00 131.17 5.52 3.80 diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder-topology.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder-topology.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,28 @@ +N Id Method Threshold Avg Score Cover Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length kDa I.P Avg Hydropathy Avg Cover +1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.65 - PETQSSHSAW 73 83 N 0 - 10 1.13 5.25 -1.40 0.98 + Emini 0.80 2.57 0.90 EEEEEEEEE. + Parker 0.80 4.19 1.00 EEEEEEEEEE + Chou Fosman 0.80 1.13 1.00 EEEEEEEEEE + Karplus Schulz 0.80 1.04 1.00 EEEEEEEEEE + Kolaskar 0.80 0.99 1.00 EEEEEEEEEE + All matches - - 0.90 EEEEEEEEE. + N-Glyc - - - .......... + Hydropathy - -1.40 - --------+- +2 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.64 - AIFLKWHVPPELVR 149 163 N 0 - 14 1.71 8.80 0.42 0.60 + Emini 0.80 0.82 0.43 .....EEEE.EE.. + Parker 0.80 -1.83 0.07 .......E...... + Chou Fosman 0.80 0.83 0.50 .....EEEEEEE.. + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEE + Kolaskar 0.80 1.10 1.00 EEEEEEEEEEEEEE + All matches - - 0.07 .......E...... + N-Glyc - - - .............. + Hydropathy - 0.42 - ++++---+---++- +3 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.63 - LKWHVPPELVRVLSA 150 165 N 0 - 15 1.74 8.75 0.39 0.59 + Emini 0.80 0.81 0.40 ..EEEE.EE...... + Parker 0.80 -1.70 0.07 ....E.......... + Chou Fosman 0.80 0.84 0.47 ..EEEEEEE...... + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEE + All matches - - 0.07 ....E.......... + N-Glyc - - - ............... + Hydropathy - 0.39 - +---+---++-++-+ diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder.log --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder.log Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,14 @@ +makeblastdb -dbtype prot -in /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta -out ./command-test_proteom Success: + + +Building a new DB, current time: 03/20/2021 00:04:04 +New DB name: /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/command-test_proteom +New DB title: /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta +Sequence type: Protein +Keep Linkouts: T +Keep MBits: T +Maximum file size: 1000000000B +Adding sequences from FASTA; added 6 sequences in 0.00420094 seconds. +Error: +blastp -query ./command-epifinder-epitopes-fasta.fasta -db ./command-test_proteom -outfmt 6 qacc sacc pident qcovs qseq sseq qacc -task blastp-short -word_size 4 -out ./command-test_proteom_blast.csv Success: +Error: diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder.txt --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-epifinder.txt Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,80 @@ + +---- Running Parameters ---- +BepiPred-2.0 Threshold : 0.6 +Min epitope length : 10 +Max epitope length : 30 + +---- Softwares Threshold ---- +Emini : 0.8 +Parker : 0.8 +Chou Fosman : 0.8 +Karplus Schulz : 0.8 +Kolaskar : 0.8 + +---- Proteomes ---- +Alias File +test_proteom /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta + +---- Blast ---- +Identity : 90.0 +Cover : 90.0 +Word size : 4 +Task blastp-short: blastp-short + +---- Stats ---- +Processed proteins : 6 +NGlycosylated proteins : 0 +Identified epitopes : 3 +N-glycosylated epitopes: 0 + +---- Protein Summary ---- +Id Epitopes N-Glyc +5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 0 0 +4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD 0 0 +4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 0 +4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 0 +5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. 0 0 +4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 0 0 + +---- Epitopes list ---- +N Id Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length MW(kDa) I.P Hydropathy All Matches Cover Avg Cover BepiPred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar test_proteom_count test_proteom_acc test_proteom_count test_proteom_id +1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation PETQSSHSAW 73 83 N 0 - 10 1.13 5.25 -1.40 0.90 0.98 0.65 2.57 4.19 1.13 1.04 0.99 1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 1 4WFF_B(100.00,100.00) +2 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation AIFLKWHVPPELVR 149 163 N 0 - 14 1.71 8.80 0.42 0.07 0.60 0.64 0.82 -1.83 0.83 0.96 1.10 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) +3 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation LKWHVPPELVRVLSA 150 165 N 0 - 15 1.74 8.75 0.39 0.07 0.59 0.63 0.81 -1.70 0.84 0.96 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) + +---- Epitopes topology ---- +N Id Method Threshold Avg Score Cover Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length kDa I.P Avg Hydropathy Avg Cover +1 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.65 - PETQSSHSAW 73 83 N 0 - 10 1.13 5.25 -1.40 0.98 + Emini 0.80 2.57 0.90 EEEEEEEEE. + Parker 0.80 4.19 1.00 EEEEEEEEEE + Chou Fosman 0.80 1.13 1.00 EEEEEEEEEE + Karplus Schulz 0.80 1.04 1.00 EEEEEEEEEE + Kolaskar 0.80 0.99 1.00 EEEEEEEEEE + All matches - - 0.90 EEEEEEEEE. + N-Glyc - - - .......... + Hydropathy - -1.40 - --------+- +2 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.64 - AIFLKWHVPPELVR 149 163 N 0 - 14 1.71 8.80 0.42 0.60 + Emini 0.80 0.82 0.43 .....EEEE.EE.. + Parker 0.80 -1.83 0.07 .......E...... + Chou Fosman 0.80 0.83 0.50 .....EEEEEEE.. + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEE + Kolaskar 0.80 1.10 1.00 EEEEEEEEEEEEEE + All matches - - 0.07 .......E...... + N-Glyc - - - .............. + Hydropathy - 0.42 - ++++---+---++- +3 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation BepiPred-2.0 0.60 0.63 - LKWHVPPELVRVLSA 150 165 N 0 - 15 1.74 8.75 0.39 0.59 + Emini 0.80 0.81 0.40 ..EEEE.EE...... + Parker 0.80 -1.70 0.07 ....E.......... + Chou Fosman 0.80 0.84 0.47 ..EEEEEEE...... + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEE + All matches - - 0.07 ....E.......... + N-Glyc - - - ............... + Hydropathy - 0.39 - +---+---++-++-+ +Generated files: + ./command-epifinder-parameters.txt + ./command-epifinder-protein-summary.tsv + ./command-epifinder-topology.tsv + ./command-epifinder-epitope-detail.tsv + ./command-epifinder-scores.tsv + ./command-epifinder-epitopes-fasta.fasta \ No newline at end of file diff -r 000000000000 -r ef26009cd70a test-data/command-epifinder.xls Binary file test-data/command-epifinder.xls has changed diff -r 000000000000 -r ef26009cd70a test-data/command-test_proteom.phr Binary file test-data/command-test_proteom.phr has changed diff -r 000000000000 -r ef26009cd70a test-data/command-test_proteom.pin Binary file test-data/command-test_proteom.pin has changed diff -r 000000000000 -r ef26009cd70a test-data/command-test_proteom.psq Binary file test-data/command-test_proteom.psq has changed diff -r 000000000000 -r ef26009cd70a test-data/command-test_proteom_blast.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/command-test_proteom_blast.csv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,6 @@ +qacc sacc pident qcovs qseq sseq qacc +1-PETQSSHSAW 4WFF_B 100.00 100 PETQSSHSAW PETQSSHSAW +2-AIFLKWHVPPELVR 4WFF_B 100.00 100 AIFLKWHVPPELVR AIFLKWHVPPELVR +2-AIFLKWHVPPELVR 4WFF_A 100.00 100 AIFLKWHVPPELVR AIFLKWHVPPELVR +3-LKWHVPPELVRVLSA 4WFF_B 100.00 100 LKWHVPPELVRVLSA LKWHVPPELVRVLSA +3-LKWHVPPELVRVLSA 4WFF_A 100.00 100 LKWHVPPELVRVLSA LKWHVPPELVRVLSA diff -r 000000000000 -r ef26009cd70a test-data/input_bcell_command_line.txt --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/input_bcell_command_line.txt Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,1153 @@ +input: 5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. +Position Residue Score Assignment +0 C 0.243 E +1 D 0.294 E +2 A 0.340 E +3 F 0.402 E +4 V 0.452 E +5 G 0.469 E +6 T 0.488 E +7 W 0.502 E +8 K 0.522 E +9 L 0.533 E +10 V 0.554 E +11 S 0.562 E +12 S 0.573 E +13 E 0.582 E +14 N 0.576 E +15 F 0.554 E +16 D 0.546 E +17 D 0.545 E +18 Y 0.535 E +19 M 0.529 E +20 K 0.527 E +21 E 0.520 E +22 V 0.526 E +23 G 0.536 E +24 V 0.547 E +25 G 0.548 E +26 F 0.544 E +27 A 0.542 E +28 T 0.517 E +29 R 0.525 E +30 K 0.521 E +31 V 0.512 E +32 A 0.510 E +33 G 0.508 E +34 M 0.497 E +35 A 0.479 E +36 K 0.472 E +37 P 0.463 E +38 N 0.452 E +39 M 0.450 E +40 I 0.453 E +41 I 0.448 E +42 S 0.458 E +43 V 0.468 E +44 N 0.468 E +45 G 0.466 E +46 D 0.467 E +47 L 0.467 E +48 V 0.460 E +49 T 0.457 E +50 I 0.454 E +51 R 0.447 E +52 S 0.448 E +53 E 0.469 E +54 S 0.486 E +55 T 0.502 E +56 F 0.508 E +57 K 0.509 E +58 N 0.501 E +59 T 0.486 E +60 E 0.477 E +61 I 0.473 E +62 S 0.458 E +63 F 0.454 E +64 K 0.464 E +65 L 0.462 E +66 G 0.468 E +67 V 0.489 E +68 E 0.519 E +69 F 0.531 E +70 D 0.538 E +71 E 0.556 E +72 I 0.569 E +73 T 0.582 E +74 A 0.589 E +75 D 0.577 E +76 D 0.557 E +77 R 0.543 E +78 K 0.523 E +79 V 0.494 E +80 K 0.475 E +81 S 0.455 E +82 I 0.432 E +83 I 0.421 E +84 T 0.427 E +85 L 0.427 E +86 D 0.426 E +87 G 0.437 E +88 G 0.461 E +89 A 0.458 E +90 L 0.473 E +91 V 0.486 E +92 Q 0.502 E +93 V 0.515 E +94 Q 0.529 E +95 K 0.540 E +96 W 0.547 E +97 D 0.551 E +98 G 0.560 E +99 K 0.551 E +100 S 0.547 E +101 T 0.543 E +102 T 0.530 E +103 I 0.520 E +104 K 0.515 E +105 R 0.505 E +106 K 0.505 E +107 R 0.507 E +108 D 0.499 E +109 G 0.490 E +110 D 0.468 E +111 K 0.458 E +112 L 0.438 E +113 V 0.433 E +114 V 0.433 E +115 E 0.426 E +116 C 0.415 E +117 V 0.413 E +118 M 0.415 E +119 K 0.424 E +120 G 0.426 E +121 V 0.448 E +122 T 0.442 E +123 S 0.436 E +124 T 0.439 E +125 R 0.447 E +126 V 0.453 E +127 Y 0.401 E +128 E 0.353 E +129 R 0.308 E +130 A 0.251 E +input: 5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta +Position Residue Score Assignment +0 V 0.228 E +1 R 0.273 E +2 S 0.308 E +3 L 0.333 E +4 N 0.388 E +5 C 0.399 E +6 T 0.409 E +7 L 0.419 E +8 R 0.440 E +9 D 0.451 E +10 S 0.456 E +11 Q 0.449 E +12 Q 0.450 E +13 K 0.430 E +14 S 0.433 E +15 L 0.430 E +16 V 0.424 E +17 M 0.415 E +18 S 0.406 E +19 G 0.390 E +20 P 0.414 E +21 Y 0.415 E +22 E 0.427 E +23 L 0.425 E +24 K 0.425 E +25 A 0.439 E +26 L 0.456 E +27 H 0.482 E +28 L 0.523 E +29 Q 0.540 E +30 G 0.576 E +31 Q 0.591 E +32 D 0.609 E +33 M 0.600 E +34 E 0.582 E +35 Q 0.542 E +36 Q 0.512 E +37 V 0.469 E +38 V 0.456 E +39 F 0.437 E +40 S 0.421 E +41 M 0.414 E +42 S 0.436 E +43 F 0.459 E +44 V 0.502 E +45 Q 0.525 E +46 G 0.552 E +47 E 0.559 E +48 E 0.575 E +49 S 0.584 E +50 N 0.559 E +51 D 0.524 E +52 K 0.485 E +53 I 0.448 E +54 P 0.417 E +55 V 0.394 E +56 A 0.388 E +57 L 0.385 E +58 G 0.388 E +59 L 0.405 E +60 K 0.428 E +61 E 0.439 E +62 K 0.442 E +63 N 0.440 E +64 L 0.441 E +65 Y 0.434 E +66 L 0.429 E +67 S 0.426 E +68 C 0.427 E +69 V 0.428 E +70 L 0.435 E +71 K 0.448 E +72 D 0.460 E +73 D 0.453 E +74 K 0.454 E +75 P 0.439 E +76 T 0.448 E +77 L 0.459 E +78 Q 0.477 E +79 L 0.490 E +80 E 0.500 E +81 S 0.521 E +82 V 0.553 E +83 D 0.562 E +84 P 0.591 E +85 K 0.591 E +86 N 0.587 E +87 Y 0.579 E +88 P 0.559 E +89 K 0.550 E +90 K 0.534 E +91 K 0.523 E +92 M 0.513 E +93 E 0.492 E +94 K 0.475 E +95 R 0.460 E +96 F 0.446 E +97 V 0.460 E +98 F 0.471 E +99 N 0.485 E +100 K 0.499 E +101 I 0.512 E +102 E 0.538 E +103 I 0.543 E +104 N 0.559 E +105 N 0.539 E +106 K 0.536 E +107 L 0.510 E +108 E 0.490 E +109 F 0.477 E +110 E 0.469 E +111 S 0.448 E +112 A 0.447 E +113 Q 0.418 E +114 F 0.422 E +115 P 0.394 E +116 N 0.385 E +117 W 0.376 E +118 Y 0.370 E +119 I 0.383 E +120 S 0.391 E +121 T 0.406 E +122 S 0.433 E +123 Q 0.448 E +124 A 0.474 E +125 E 0.481 E +126 N 0.491 E +127 M 0.475 E +128 P 0.451 E +129 V 0.453 E +130 F 0.454 E +131 L 0.456 E +132 G 0.473 E +133 G 0.488 E +134 G 0.508 E +135 G 0.516 E +136 Q 0.540 E +137 D 0.535 E +138 I 0.521 E +139 T 0.493 E +140 D 0.485 E +141 F 0.478 E +142 T 0.468 E +143 M 0.466 E +144 Q 0.471 E +145 F 0.414 E +146 V 0.376 E +147 S 0.328 E +148 S 0.290 E +input: 4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD +Position Residue Score Assignment +0 V 0.269 E +1 E 0.332 E +2 C 0.394 E +3 D 0.452 E +4 F 0.519 E +5 S 0.526 E +6 P 0.542 E +7 L 0.539 E +8 L 0.532 E +9 S 0.525 E +10 G 0.525 E +11 T 0.519 E +12 P 0.523 E +13 P 0.513 E +14 Q 0.501 E +15 V 0.501 E +16 Y 0.503 E +17 N 0.505 E +18 F 0.505 E +19 K 0.493 E +20 R 0.489 E +21 L 0.495 E +22 V 0.501 E +23 F 0.521 E +24 T 0.531 E +25 N 0.544 E +26 C 0.542 E +27 N 0.548 E +28 Y 0.565 E +29 N 0.561 E +30 L 0.559 E +31 T 0.560 E +32 K 0.548 E +33 L 0.552 E +34 L 0.550 E +35 S 0.556 E +36 L 0.569 E +37 F 0.566 E +38 S 0.579 E +39 V 0.580 E +40 N 0.571 E +41 D 0.576 E +42 F 0.573 E +43 T 0.564 E +44 C 0.569 E +45 S 0.551 E +46 Q 0.542 E +47 I 0.538 E +48 S 0.518 E +49 P 0.512 E +50 A 0.513 E +51 A 0.511 E +52 I 0.522 E +53 A 0.530 E +54 S 0.545 E +55 N 0.554 E +56 C 0.562 E +57 Y 0.570 E +58 S 0.577 E +59 S 0.567 E +60 L 0.558 E +61 I 0.547 E +62 L 0.536 E +63 D 0.531 E +64 Y 0.519 E +65 F 0.515 E +66 S 0.525 E +67 Y 0.536 E +68 P 0.549 E +69 L 0.562 E +70 S 0.572 E +71 M 0.582 E +72 K 0.593 E +73 S 0.610 E +74 D 0.628 E +75 L 0.625 E +76 S 0.618 E +77 V 0.608 E +78 S 0.590 E +79 S 0.582 E +80 A 0.579 E +81 G 0.568 E +82 P 0.563 E +83 I 0.549 E +84 S 0.547 E +85 Q 0.555 E +86 F 0.569 E +87 N 0.581 E +88 Y 0.578 E +89 K 0.582 E +90 Q 0.582 E +91 S 0.572 E +92 F 0.568 E +93 S 0.569 E +94 N 0.561 E +95 P 0.536 E +96 T 0.525 E +97 C 0.516 E +98 L 0.507 E +99 I 0.500 E +100 L 0.505 E +101 A 0.511 E +102 T 0.520 E +103 V 0.513 E +104 P 0.523 E +105 H 0.534 E +106 N 0.538 E +107 L 0.531 E +108 T 0.539 E +109 T 0.529 E +110 I 0.518 E +111 T 0.501 E +112 K 0.510 E +113 P 0.504 E +114 L 0.499 E +115 K 0.507 E +116 Y 0.520 E +117 S 0.525 E +118 Y 0.532 E +119 I 0.534 E +120 N 0.547 E +121 K 0.545 E +122 C 0.558 E +123 S 0.556 E +124 R 0.560 E +125 F 0.559 E +126 L 0.557 E +127 S 0.559 E +128 D 0.556 E +129 D 0.539 E +130 R 0.532 E +131 T 0.532 E +132 E 0.530 E +133 V 0.527 E +134 P 0.533 E +135 Q 0.527 E +136 L 0.552 E +137 V 0.570 E +138 N 0.591 E +139 A 0.607 E +140 N 0.604 E +141 Q 0.604 E +142 Y 0.603 E +143 S 0.588 E +144 P 0.582 E +145 C 0.549 E +146 V 0.523 E +147 S 0.512 E +148 I 0.506 E +149 V 0.505 E +150 P 0.514 E +151 S 0.512 E +152 T 0.512 E +153 V 0.512 E +154 W 0.521 E +155 E 0.522 E +156 D 0.518 E +157 G 0.505 E +158 D 0.517 E +159 Y 0.520 E +160 Y 0.522 E +161 R 0.528 E +162 K 0.532 E +163 Q 0.530 E +164 L 0.545 E +165 S 0.547 E +166 P 0.558 E +167 L 0.546 E +168 E 0.539 E +169 G 0.540 E +170 G 0.540 E +171 G 0.544 E +172 W 0.562 E +173 L 0.558 E +174 V 0.580 E +175 A 0.583 E +176 S 0.589 E +177 G 0.597 E +178 S 0.610 E +179 T 0.616 E +180 V 0.628 E +181 A 0.627 E +182 M 0.626 E +183 T 0.621 E +184 E 0.627 E +185 Q 0.623 E +186 L 0.607 E +187 Q 0.589 E +188 M 0.571 E +189 G 0.556 E +190 F 0.545 E +191 G 0.551 E +192 I 0.549 E +193 T 0.542 E +194 V 0.548 E +195 Q 0.558 E +196 Y 0.572 E +197 G 0.587 E +198 T 0.587 E +199 T 0.584 E +200 N 0.574 E +201 S 0.567 E +202 V 0.564 E +203 C 0.570 E +204 P 0.564 E +205 K 0.560 E +206 L 0.495 E +207 E 0.437 E +208 F 0.378 E +209 A 0.320 E +input: 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation +Position Residue Score Assignment +0 R 0.182 E +1 S 0.223 E +2 T 0.268 E +3 T 0.291 E +4 L 0.316 E +5 L 0.313 E +6 A 0.310 E +7 L 0.295 E +8 L 0.285 E +9 A 0.279 E +10 L 0.269 E +11 V 0.252 E +12 L 0.251 E +13 L 0.266 E +14 Y 0.276 E +15 L 0.291 E +16 V 0.313 E +17 S 0.324 E +18 G 0.309 E +19 A 0.328 E +20 L 0.351 E +21 V 0.358 E +22 F 0.366 E +23 R 0.398 E +24 A 0.426 E +25 L 0.440 E +26 E 0.464 E +27 Q 0.507 E +28 P 0.524 E +29 H 0.533 E +30 E 0.572 E +31 Q 0.593 E +32 Q 0.591 E +33 A 0.574 E +34 Q 0.574 E +35 R 0.572 E +36 E 0.572 E +37 L 0.566 E +38 G 0.575 E +39 E 0.566 E +40 V 0.537 E +41 R 0.528 E +42 E 0.548 E +43 K 0.549 E +44 F 0.545 E +45 L 0.541 E +46 R 0.542 E +47 A 0.536 E +48 H 0.541 E +49 P 0.567 E +50 C 0.572 E +51 V 0.584 E +52 S 0.577 E +53 D 0.583 E +54 Q 0.577 E +55 E 0.550 E +56 L 0.533 E +57 G 0.526 E +58 L 0.507 E +59 L 0.471 E +60 I 0.444 E +61 K 0.443 E +62 E 0.432 E +63 V 0.416 E +64 A 0.443 E +65 D 0.455 E +66 A 0.463 E +67 L 0.473 E +68 G 0.514 E +69 G 0.532 E +70 G 0.553 E +71 A 0.588 E +72 D 0.623 E +73 P 0.631 E +74 E 0.647 E +75 T 0.651 E +76 S 0.653 E +77 H 0.645 E +78 S 0.627 E +79 A 0.610 E +80 W 0.577 E +81 D 0.544 E +82 L 0.519 E +83 G 0.493 E +84 S 0.457 E +85 A 0.424 E +86 F 0.395 E +87 F 0.380 E +88 F 0.353 E +89 S 0.339 E +90 G 0.338 E +91 T 0.348 E +92 I 0.365 E +93 I 0.394 E +94 T 0.435 E +95 T 0.477 E +96 I 0.501 E +97 G 0.534 E +98 Y 0.562 E +99 G 0.573 E +100 N 0.595 E +101 V 0.583 E +102 A 0.581 E +103 L 0.573 E +104 R 0.549 E +105 T 0.538 E +106 D 0.520 E +107 A 0.490 E +108 G 0.467 E +109 R 0.417 E +110 L 0.389 E +111 F 0.357 E +112 C 0.321 E +113 I 0.301 E +114 F 0.277 E +115 Y 0.263 E +116 A 0.260 E +117 L 0.270 E +118 V 0.277 E +119 G 0.286 E +120 I 0.289 E +121 P 0.310 E +122 L 0.316 E +123 F 0.322 E +124 G 0.329 E +125 I 0.339 E +126 L 0.347 E +127 L 0.366 E +128 A 0.393 E +129 G 0.430 E +130 V 0.444 E +131 G 0.458 E +132 D 0.472 E +133 R 0.484 E +134 L 0.485 E +135 G 0.504 E +136 S 0.510 E +137 S 0.500 E +138 L 0.497 E +139 R 0.493 E +140 H 0.499 E +141 G 0.505 E +142 I 0.518 E +143 G 0.529 E +144 H 0.526 E +145 I 0.528 E +146 E 0.543 E +147 A 0.550 E +148 I 0.567 E +149 F 0.585 E +150 L 0.604 E +151 K 0.606 E +152 W 0.617 E +153 H 0.628 E +154 V 0.644 E +155 P 0.648 E +156 P 0.664 E +157 E 0.648 E +158 L 0.642 E +159 V 0.638 E +160 R 0.630 E +161 V 0.627 E +162 L 0.619 E +163 S 0.607 E +164 A 0.604 E +165 M 0.569 E +166 L 0.564 E +167 F 0.532 E +168 L 0.493 E +169 L 0.466 E +170 I 0.433 E +171 G 0.401 E +172 C 0.356 E +173 L 0.305 E +174 L 0.282 E +175 F 0.261 E +176 V 0.255 E +177 L 0.261 E +178 T 0.262 E +179 P 0.263 E +180 T 0.271 E +181 F 0.304 E +182 V 0.342 E +183 F 0.379 E +184 C 0.420 E +185 Y 0.445 E +186 M 0.481 E +187 E 0.509 E +188 D 0.532 E +189 W 0.540 E +190 S 0.528 E +191 K 0.515 E +192 L 0.470 E +193 E 0.427 E +194 A 0.393 E +195 I 0.352 E +196 Y 0.320 E +197 F 0.288 E +198 V 0.262 E +199 V 0.253 E +200 T 0.243 E +201 L 0.258 E +202 T 0.280 E +203 T 0.318 E +204 V 0.345 E +205 G 0.372 E +206 F 0.404 E +207 G 0.431 E +208 D 0.459 E +209 Y 0.488 E +210 V 0.513 E +211 A 0.538 E +212 G 0.559 E +213 A 0.578 E +214 D 0.591 E +215 P 0.602 E +216 R 0.624 E +217 Q 0.639 E +218 D 0.638 E +219 S 0.631 E +220 P 0.607 E +221 A 0.579 E +222 Y 0.545 E +223 Q 0.519 E +224 P 0.487 E +225 L 0.446 E +226 V 0.400 E +227 W 0.365 E +228 F 0.329 E +229 W 0.304 E +230 I 0.282 E +231 L 0.281 E +232 L 0.288 E +233 G 0.281 E +234 L 0.274 E +235 A 0.285 E +236 Y 0.293 E +237 F 0.317 E +238 A 0.339 E +239 S 0.367 E +240 V 0.360 E +241 L 0.349 E +242 T 0.374 E +243 T 0.406 E +244 I 0.403 E +245 G 0.427 E +246 N 0.435 E +247 W 0.426 E +248 L 0.372 E +249 R 0.337 E +250 V 0.296 E +251 V 0.243 E +input: 4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation +Position Residue Score Assignment +0 R 0.185 E +1 S 0.226 E +2 T 0.274 E +3 T 0.297 E +4 L 0.323 E +5 L 0.319 E +6 A 0.314 E +7 L 0.300 E +8 L 0.291 E +9 A 0.286 E +10 L 0.275 E +11 V 0.255 E +12 L 0.253 E +13 L 0.269 E +14 Y 0.281 E +15 L 0.297 E +16 V 0.318 E +17 S 0.327 E +18 G 0.314 E +19 A 0.333 E +20 L 0.360 E +21 V 0.368 E +22 F 0.375 E +23 R 0.406 E +24 A 0.438 E +25 L 0.455 E +26 E 0.484 E +27 Q 0.526 E +28 P 0.543 E +29 H 0.551 E +30 E 0.589 E +31 Q 0.610 E +32 Q 0.609 E +33 A 0.586 E +34 Q 0.581 E +35 R 0.576 E +36 E 0.577 E +37 L 0.570 E +38 G 0.581 E +39 E 0.575 E +40 V 0.548 E +41 R 0.528 E +42 E 0.551 E +43 K 0.552 E +44 F 0.546 E +45 L 0.537 E +46 R 0.538 E +47 A 0.531 E +48 H 0.534 E +49 P 0.556 E +50 C 0.569 E +51 V 0.578 E +52 S 0.573 E +53 D 0.577 E +54 Q 0.575 E +55 E 0.546 E +56 L 0.520 E +57 G 0.509 E +58 L 0.490 E +59 L 0.456 E +60 I 0.426 E +61 K 0.424 E +62 E 0.413 E +63 V 0.393 E +64 A 0.418 E +65 D 0.436 E +66 A 0.444 E +67 L 0.442 E +68 G 0.480 E +69 G 0.503 E +70 G 0.523 E +71 A 0.552 E +72 D 0.591 E +73 P 0.618 E +74 E 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+4Z5R_A,144,S,E,0.419,0.600,0.003,0.397,0.295111111111 +4Z5R_A,145,L,E,0.541,0.053,0.005,0.942,0.243555555556 + diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-epitope-detail.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-epitope-detail.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,3 @@ +N Id Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length MW(kDa) I.P Hydropathy All Matches Cover Avg Cover BepiPred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar test_proteom_count test_proteom_acc test_proteom_count test_proteom_id +1 4WFF_A FLKWHVPPELVRVLSA 149 165 N 0 - 16 1.89 8.75 0.54 0.06 0.58 0.64 0.78 -1.78 0.83 0.96 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) +2 4WFF_B AIFLKWHVPPELVRVLSAML 149 169 N 0 - 20 2.32 8.80 1.03 0.05 0.54 0.64 0.67 -2.18 0.80 0.95 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-epitopes-fasta.fasta --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-epitopes-fasta.fasta Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,4 @@ +>1-FLKWHVPPELVRVLSA +FLKWHVPPELVRVLSA +>2-AIFLKWHVPPELVRVLSAML +AIFLKWHVPPELVRVLSAML diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-parameters.txt --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-parameters.txt Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,28 @@ + +---- Running Parameters ---- +BepiPred-2.0 Threshold : 0.6 +Min epitope length : 10 +Max epitope length : 30 + +---- Softwares Threshold ---- +Emini : 0.8 +Parker : 0.8 +Chou Fosman : 0.8 +Karplus Schulz : 0.8 +Kolaskar : 0.8 + +---- Proteomes ---- +Alias File +test_proteom /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta + +---- Blast ---- +Identity : 90.0 +Cover : 90.0 +Word size : 4 +Task blastp-short: blastp-short + +---- Stats ---- +Processed proteins : 6 +NGlycosylated proteins : 0 +Identified epitopes : 2 +N-glycosylated epitopes: 0 diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-protein-summary.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-protein-summary.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,7 @@ +Id Epitopes N-Glyc +4WFF_B 1 0 +5BVP_A 0 0 +4XAK_A 0 0 +4WFF_A 1 0 +5C0N_A 0 0 +4Z5R_A 0 0 diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-scores.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-scores.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,1141 @@ +Id Position Residue Bepipred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar MW IP Hydropathy +4WFF_B 1 R 0.18 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_B 2 S 0.22 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4WFF_B 3 T 0.26 1.27 0.00 0.00 0.00 0.00 119.12 5.19 -0.70 +4WFF_B 4 T 0.28 0.66 0.69 0.88 1.03 1.04 119.12 5.19 -0.70 +4WFF_B 5 L 0.31 0.40 -1.23 0.83 0.99 1.09 131.17 5.52 3.80 +4WFF_B 6 L 0.31 0.23 -3.47 0.71 0.95 1.13 131.17 5.52 3.80 +4WFF_B 7 A 0.31 0.16 -3.91 0.66 0.93 1.15 89.09 5.57 1.80 +4WFF_B 8 L 0.29 0.16 -5.97 0.61 0.91 1.20 131.17 5.52 3.80 +4WFF_B 9 L 0.28 0.15 -5.19 0.60 0.91 1.22 131.17 5.52 3.80 +4WFF_B 10 A 0.27 0.12 -5.19 0.60 0.91 1.22 89.09 5.57 1.80 +4WFF_B 11 L 0.26 0.12 -6.80 0.59 0.91 1.24 131.17 5.52 3.80 +4WFF_B 12 V 0.24 0.23 -5.76 0.67 0.91 1.23 117.15 5.49 4.20 +4WFF_B 13 L 0.24 0.18 -5.76 0.67 0.91 1.23 131.17 5.52 3.80 +4WFF_B 14 L 0.26 0.17 -6.59 0.64 0.90 1.28 131.17 5.52 3.80 +4WFF_B 15 Y 0.26 0.30 -4.34 0.76 0.91 1.24 181.19 5.52 -1.30 +4WFF_B 16 L 0.28 0.36 -3.00 0.91 0.93 1.17 131.17 5.52 3.80 +4WFF_B 17 V 0.30 0.44 -1.39 0.92 0.95 1.14 117.15 5.49 4.20 +4WFF_B 18 S 0.31 0.23 -1.39 0.92 0.97 1.14 105.09 5.24 -0.80 +4WFF_B 19 G 0.30 0.21 -1.64 0.83 0.98 1.17 75.07 5.52 -0.40 +4WFF_B 20 A 0.32 0.24 -1.64 0.83 0.96 1.15 89.09 5.57 1.80 +4WFF_B 21 L 0.34 0.36 -0.51 0.90 0.94 1.08 131.17 5.52 3.80 +4WFF_B 22 V 0.36 0.36 -1.14 0.79 0.93 1.09 117.15 5.49 4.20 +4WFF_B 23 F 0.38 0.30 -3.27 0.65 0.92 1.14 165.19 5.52 2.80 +4WFF_B 24 R 0.42 0.62 -2.46 0.66 0.93 1.11 174.20 9.75 -4.50 +4WFF_B 25 A 0.45 1.45 -0.29 0.72 0.96 1.08 89.09 5.57 1.80 +4WFF_B 26 L 0.47 2.59 0.54 0.86 0.99 1.03 131.17 5.52 3.80 +4WFF_B 27 E 0.50 1.80 2.16 0.91 1.03 1.03 147.13 4.00 -3.50 +4WFF_B 28 Q 0.54 3.09 2.67 0.88 1.06 1.03 146.15 5.52 -3.50 +4WFF_B 29 P 0.55 6.48 3.23 0.93 1.07 1.02 115.13 5.96 -1.60 +4WFF_B 30 H 0.57 6.48 5.40 0.98 1.06 0.99 155.16 6.74 -3.20 +4WFF_B 31 E 0.61 3.78 4.59 0.97 1.06 1.02 147.13 4.00 -3.50 +4WFF_B 32 Q 0.61 4.23 4.59 0.97 1.06 1.02 146.15 5.52 -3.50 +4WFF_B 33 Q 0.61 6.09 4.89 0.89 1.05 0.99 146.15 5.52 -3.50 +4WFF_B 34 A 0.58 6.09 5.70 0.86 1.05 0.95 89.09 5.57 1.80 +4WFF_B 35 Q 0.58 2.90 3.27 0.84 1.04 1.01 146.15 5.52 -3.50 +4WFF_B 36 R 0.57 1.66 3.23 0.92 1.03 0.99 174.20 9.75 -4.50 +4WFF_B 37 E 0.57 2.84 3.49 0.89 1.02 0.97 147.13 4.00 -3.50 +4WFF_B 38 L 0.57 1.22 2.66 0.87 1.02 1.01 131.17 5.52 3.80 +4WFF_B 39 G 0.58 1.22 2.40 0.86 1.02 0.99 75.07 5.52 -0.40 +4WFF_B 40 E 0.57 1.22 2.91 0.83 1.02 0.99 147.13 4.00 -3.50 +4WFF_B 41 V 0.54 2.95 2.61 0.87 1.03 1.00 117.15 5.49 4.20 +4WFF_B 42 R 0.51 2.58 2.61 0.87 1.03 0.98 174.20 9.75 -4.50 +4WFF_B 43 E 0.54 1.23 0.49 0.73 1.03 1.03 147.13 4.00 -3.50 +4WFF_B 44 K 0.54 3.25 -0.03 0.76 1.01 1.04 146.19 8.75 -3.90 +4WFF_B 45 F 0.53 1.68 0.80 0.79 0.98 0.99 165.19 5.52 2.80 +4WFF_B 46 L 0.52 1.32 0.50 0.79 0.96 1.02 131.17 5.52 3.80 +4WFF_B 47 R 0.52 1.02 -0.31 0.90 0.94 1.05 174.20 9.75 -4.50 +4WFF_B 48 A 0.51 0.63 -0.93 0.92 0.93 1.12 89.09 5.57 1.80 +4WFF_B 49 H 0.51 0.57 -0.14 0.91 0.93 1.16 155.16 6.74 -3.20 +4WFF_B 50 P 0.54 0.39 2.10 1.03 0.93 1.13 115.13 5.96 -1.60 +4WFF_B 51 C 0.56 0.64 2.93 1.10 0.94 1.13 121.15 5.52 2.50 +4WFF_B 52 V 0.57 0.82 3.49 1.15 0.97 1.12 117.15 5.49 4.20 +4WFF_B 53 S 0.57 0.91 4.30 1.12 1.01 1.09 105.09 5.24 -0.80 +4WFF_B 54 D 0.58 1.41 2.69 0.98 1.03 1.11 133.10 3.80 -3.50 +4WFF_B 55 Q 0.58 1.88 3.30 1.04 1.05 1.04 146.15 5.52 -3.50 +4WFF_B 56 E 0.55 1.15 2.51 1.05 1.03 1.02 147.13 4.00 -3.50 +4WFF_B 57 L 0.53 0.57 0.27 0.93 1.00 1.05 131.17 5.52 3.80 +4WFF_B 58 G 0.52 0.23 -2.30 0.79 0.97 1.09 75.07 5.52 -0.40 +4WFF_B 59 L 0.50 0.27 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_B 60 L 0.47 0.56 -2.34 0.79 0.95 1.08 131.17 5.52 3.80 +4WFF_B 61 I 0.44 0.42 -1.56 0.78 0.96 1.10 131.17 5.52 4.50 +4WFF_B 62 K 0.44 0.51 -2.07 0.65 0.98 1.13 146.19 8.75 -3.90 +4WFF_B 63 E 0.44 1.04 0.67 0.78 0.98 1.07 147.13 4.00 -3.50 +4WFF_B 64 V 0.42 1.50 2.29 0.79 0.97 1.04 117.15 5.49 4.20 +4WFF_B 65 A 0.43 0.62 2.11 0.80 0.96 1.06 89.09 5.57 1.80 +4WFF_B 66 D 0.45 0.35 2.11 0.88 0.95 1.05 133.10 3.80 -3.50 +4WFF_B 67 A 0.44 0.47 1.81 1.00 0.97 1.05 89.09 5.57 1.80 +4WFF_B 68 L 0.44 0.46 3.16 1.15 1.00 0.98 131.17 5.52 3.80 +4WFF_B 69 G 0.48 0.28 3.16 1.15 1.03 0.98 75.07 5.52 -0.40 +4WFF_B 70 G 0.50 0.46 3.16 1.15 1.05 0.98 75.07 5.52 -0.40 +4WFF_B 71 G 0.51 0.87 3.16 1.27 1.06 0.98 75.07 5.52 -0.40 +4WFF_B 72 A 0.53 1.51 5.59 1.29 1.07 0.92 89.09 5.57 1.80 +4WFF_B 73 D 0.57 2.21 5.51 1.21 1.07 0.93 133.10 3.80 -3.50 +4WFF_B 74 P 0.61 3.87 5.56 1.13 1.08 0.95 115.13 5.96 -1.60 +4WFF_B 75 E 0.62 5.13 5.67 1.11 1.09 0.97 147.13 4.00 -3.50 +4WFF_B 76 T 0.64 4.11 6.30 1.22 1.10 0.96 119.12 5.19 -0.70 +4WFF_B 77 Q 0.67 3.62 5.17 1.14 1.11 1.00 146.15 5.52 -3.50 +4WFF_B 78 S 0.68 2.80 5.80 1.13 1.09 0.99 105.09 5.24 -0.80 +4WFF_B 79 S 0.67 1.96 4.99 1.12 1.05 1.02 105.09 5.24 -0.80 +4WFF_B 80 H 0.66 1.19 2.81 1.12 1.01 1.02 155.16 6.74 -3.20 +4WFF_B 81 S 0.64 1.48 3.39 1.19 0.97 0.99 105.09 5.24 -0.80 +4WFF_B 82 A 0.61 0.91 1.14 1.07 0.95 1.03 89.09 5.57 1.80 +4WFF_B 83 W 0.57 0.66 1.03 1.09 0.94 1.01 204.23 5.52 -0.90 +4WFF_B 84 D 0.54 0.66 1.66 1.16 0.96 1.00 133.10 3.80 -3.50 +4WFF_B 85 L 0.49 0.66 1.03 1.05 0.98 1.00 131.17 5.52 3.80 +4WFF_B 86 G 0.46 0.55 -0.59 1.04 0.99 1.01 75.07 5.52 -0.40 +4WFF_B 87 S 0.42 0.28 -0.47 0.99 0.99 1.04 105.09 5.24 -0.80 +4WFF_B 88 A 0.38 0.30 -3.21 0.86 0.97 1.07 89.09 5.57 1.80 +4WFF_B 89 F 0.35 0.40 -0.97 0.98 0.95 1.03 165.19 5.52 2.80 +4WFF_B 90 F 0.32 0.30 -0.97 0.98 0.96 1.03 165.19 5.52 2.80 +4WFF_B 91 F 0.30 0.43 -1.16 0.92 0.98 1.02 165.19 5.52 2.80 +4WFF_B 92 S 0.28 0.34 -2.60 0.89 1.01 1.03 105.09 5.24 -0.80 +4WFF_B 93 G 0.26 0.28 -2.43 0.87 1.02 1.04 75.07 5.52 -0.40 +4WFF_B 94 T 0.27 0.46 -0.37 0.92 1.01 1.01 119.12 5.19 -0.70 +4WFF_B 95 I 0.29 0.50 1.69 0.97 0.99 0.99 131.17 5.52 4.50 +4WFF_B 96 I 0.31 0.35 -0.39 0.84 0.98 1.01 131.17 5.52 4.50 +4WFF_B 97 T 0.35 0.24 -0.39 0.84 0.99 1.01 119.12 5.19 -0.70 +4WFF_B 98 T 0.39 0.54 -1.40 0.86 0.99 1.04 119.12 5.19 -0.70 +4WFF_B 99 I 0.43 0.77 0.56 1.02 0.99 1.00 131.17 5.52 4.50 +4WFF_B 100 G 0.45 0.85 2.70 1.17 0.99 0.95 75.07 5.52 -0.40 +4WFF_B 101 Y 0.49 0.44 1.43 1.11 0.98 1.02 181.19 5.52 -1.30 +4WFF_B 102 G 0.52 0.63 0.99 1.06 0.98 1.04 75.07 5.52 -0.40 +4WFF_B 103 N 0.55 0.53 0.81 1.08 0.97 1.05 132.12 5.52 -3.50 +4WFF_B 104 V 0.56 0.66 0.60 0.99 0.96 1.05 117.15 5.49 4.20 +4WFF_B 105 A 0.56 0.96 1.61 0.97 0.96 1.02 89.09 5.57 1.80 +4WFF_B 106 L 0.55 1.00 2.23 0.95 0.98 1.02 131.17 5.52 3.80 +4WFF_B 107 R 0.53 1.36 1.53 0.83 1.01 1.06 174.20 9.75 -4.50 +4WFF_B 108 T 0.51 1.33 2.87 0.98 1.04 0.99 119.12 5.19 -0.70 +4WFF_B 109 D 0.50 3.16 3.17 1.02 1.05 0.96 133.10 3.80 -3.50 +4WFF_B 110 A 0.48 1.33 3.17 1.02 1.05 0.96 89.09 5.57 1.80 +4WFF_B 111 G 0.45 0.80 1.26 0.97 1.03 0.99 75.07 5.52 -0.40 +4WFF_B 112 R 0.41 0.26 0.71 1.00 1.00 1.06 174.20 9.75 -4.50 +4WFF_B 113 L 0.38 0.18 -1.86 0.86 0.97 1.10 131.17 5.52 3.80 +4WFF_B 114 F 0.35 0.16 -3.47 0.85 0.94 1.11 165.19 5.52 2.80 +4WFF_B 115 C 0.33 0.12 -4.56 0.79 0.92 1.15 121.15 5.52 2.50 +4WFF_B 116 I 0.30 0.15 -4.86 0.75 0.90 1.17 131.17 5.52 4.50 +4WFF_B 117 F 0.28 0.15 -4.86 0.75 0.89 1.17 165.19 5.52 2.80 +4WFF_B 118 Y 0.27 0.20 -4.07 0.74 0.89 1.22 181.19 5.52 -1.30 +4WFF_B 119 A 0.26 0.28 -3.46 0.79 0.89 1.14 89.09 5.57 1.80 +4WFF_B 120 L 0.27 0.23 -3.46 0.79 0.91 1.14 131.17 5.52 3.80 +4WFF_B 121 V 0.27 0.23 -1.84 0.92 0.92 1.14 117.15 5.49 4.20 +4WFF_B 122 G 0.28 0.19 -2.89 0.84 0.94 1.15 75.07 5.52 -0.40 +4WFF_B 123 I 0.27 0.19 -4.50 0.83 0.95 1.15 131.17 5.52 4.50 +4WFF_B 124 P 0.28 0.26 -2.37 0.97 0.95 1.10 115.13 5.96 -1.60 +4WFF_B 125 L 0.29 0.18 -2.99 0.97 0.94 1.07 131.17 5.52 3.80 +4WFF_B 126 F 0.30 0.22 -5.11 0.83 0.93 1.12 165.19 5.52 2.80 +4WFF_B 127 G 0.31 0.12 -5.29 0.85 0.92 1.13 75.07 5.52 -0.40 +4WFF_B 128 I 0.32 0.14 -5.29 0.72 0.92 1.13 131.17 5.52 4.50 +4WFF_B 129 L 0.33 0.16 -3.16 0.86 0.92 1.08 131.17 5.52 3.80 +4WFF_B 130 L 0.35 0.12 -2.37 0.85 0.93 1.12 131.17 5.52 3.80 +4WFF_B 131 A 0.38 0.17 -2.37 0.85 0.94 1.12 89.09 5.57 1.80 +4WFF_B 132 G 0.42 0.35 0.20 0.99 0.96 1.08 75.07 5.52 -0.40 +4WFF_B 133 V 0.44 0.82 2.11 1.04 0.98 1.03 117.15 5.49 4.20 +4WFF_B 134 G 0.45 0.67 2.11 1.04 1.00 1.03 75.07 5.52 -0.40 +4WFF_B 135 D 0.47 0.67 2.63 1.17 1.01 1.00 133.10 3.80 -3.50 +4WFF_B 136 R 0.49 1.21 2.74 1.15 1.03 1.02 174.20 9.75 -4.50 +4WFF_B 137 L 0.49 1.64 4.20 1.28 1.04 0.97 131.17 5.52 3.80 +4WFF_B 138 G 0.51 0.81 2.07 1.14 1.05 1.02 75.07 5.52 -0.40 +4WFF_B 139 S 0.51 0.81 1.24 1.07 1.05 1.02 105.09 5.24 -0.80 +4WFF_B 140 S 0.51 1.34 0.94 1.07 1.03 1.05 105.09 5.24 -0.80 +4WFF_B 141 L 0.50 1.34 3.07 1.21 1.00 1.00 131.17 5.52 3.80 +4WFF_B 142 R 0.50 0.70 1.11 1.05 0.97 1.04 174.20 9.75 -4.50 +4WFF_B 143 H 0.52 0.52 1.00 1.07 0.96 1.02 155.16 6.74 -3.20 +4WFF_B 144 G 0.53 0.85 0.37 1.00 0.95 1.03 75.07 5.52 -0.40 +4WFF_B 145 I 0.55 0.31 0.54 0.99 0.95 1.02 131.17 5.52 4.50 +4WFF_B 146 G 0.56 0.39 1.06 0.96 0.94 1.02 75.07 5.52 -0.40 +4WFF_B 147 H 0.57 0.40 1.06 0.92 0.94 1.01 155.16 6.74 -3.20 +4WFF_B 148 I 0.59 0.40 -0.90 0.76 0.93 1.05 131.17 5.52 4.50 +4WFF_B 149 E 0.60 0.35 -1.07 0.78 0.92 1.04 147.13 4.00 -3.50 +4WFF_B 150 A 0.61 0.21 -3.20 0.64 0.92 1.10 89.09 5.57 1.80 +4WFF_B 151 I 0.62 0.60 -2.69 0.65 0.93 1.07 131.17 5.52 4.50 +4WFF_B 152 F 0.63 0.36 -2.97 0.72 0.94 1.03 165.19 5.52 2.80 +4WFF_B 153 L 0.65 0.49 -3.79 0.75 0.95 1.07 131.17 5.52 3.80 +4WFF_B 154 K 0.64 0.52 -4.61 0.73 0.95 1.11 146.19 8.75 -3.90 +4WFF_B 155 W 0.64 0.93 -3.17 0.88 0.96 1.10 204.23 5.52 -0.90 +4WFF_B 156 H 0.64 1.74 -1.56 1.01 0.96 1.10 155.16 6.74 -3.20 +4WFF_B 157 V 0.64 1.51 0.87 1.03 0.98 1.04 117.15 5.49 4.20 +4WFF_B 158 P 0.64 1.18 -1.26 0.97 1.00 1.09 115.13 5.96 -1.60 +4WFF_B 159 P 0.66 0.64 -0.36 0.90 1.01 1.16 115.13 5.96 -1.60 +4WFF_B 160 E 0.65 1.70 -0.06 0.90 1.00 1.12 147.13 4.00 -3.50 +4WFF_B 161 L 0.65 0.82 -0.06 0.90 0.98 1.12 131.17 5.52 3.80 +4WFF_B 162 V 0.65 0.44 -1.67 0.77 0.95 1.15 117.15 5.49 4.20 +4WFF_B 163 R 0.65 0.34 -1.04 0.76 0.94 1.14 174.20 9.75 -4.50 +4WFF_B 164 V 0.66 0.41 -1.86 0.75 0.93 1.17 117.15 5.49 4.20 +4WFF_B 165 L 0.66 0.55 -1.14 0.75 0.93 1.11 131.17 5.52 3.80 +4WFF_B 166 S 0.65 0.23 -1.93 0.76 0.92 1.09 105.09 5.24 -0.80 +4WFF_B 167 A 0.64 0.27 -3.84 0.71 0.91 1.13 89.09 5.57 1.80 +4WFF_B 168 M 0.60 0.27 -4.63 0.72 0.90 1.11 149.21 5.28 1.90 +4WFF_B 169 L 0.60 0.17 -4.63 0.72 0.90 1.11 131.17 5.52 3.80 +4WFF_B 170 F 0.58 0.12 -6.70 0.59 0.90 1.13 165.19 5.52 2.80 +4WFF_B 171 L 0.56 0.12 -6.19 0.71 0.91 1.10 131.17 5.52 3.80 +4WFF_B 172 L 0.55 0.07 -5.39 0.80 0.91 1.18 131.17 5.52 3.80 +4WFF_B 173 I 0.55 0.07 -5.39 0.80 0.91 1.18 131.17 5.52 4.50 +4WFF_B 174 G 0.54 0.07 -5.39 0.80 0.91 1.21 75.07 5.52 -0.40 +4WFF_B 175 C 0.53 0.07 -5.39 0.80 0.91 1.18 121.15 5.52 2.50 +4WFF_B 176 L 0.53 0.08 -4.60 0.79 0.91 1.20 131.17 5.52 3.80 +4WFF_B 177 L 0.53 0.07 -4.77 0.80 0.92 1.22 131.17 5.52 3.80 +4WFF_B 178 F 0.51 0.18 -4.84 0.72 0.93 1.22 165.19 5.52 2.80 +4WFF_B 179 V 0.51 0.33 -4.74 0.76 0.95 1.17 117.15 5.49 4.20 +4WFF_B 180 L 0.51 0.58 -2.69 0.82 0.98 1.12 131.17 5.52 3.80 +4WFF_B 181 T 0.49 0.58 -2.69 0.82 1.00 1.10 119.12 5.19 -0.70 +4WFF_B 182 P 0.48 0.58 -1.90 0.80 1.01 1.14 115.13 5.96 -1.60 +4WFF_B 183 T 0.47 0.61 -2.69 0.82 0.99 1.10 119.12 5.19 -0.70 +4WFF_B 184 F 0.47 0.23 -1.17 0.90 0.97 1.12 165.19 5.52 2.80 +4WFF_B 185 V 0.47 0.23 -2.19 0.93 0.94 1.16 117.15 5.49 4.20 +4WFF_B 186 F 0.48 0.16 -3.09 0.80 0.91 1.12 165.19 5.52 2.80 +4WFF_B 187 C 0.51 0.32 -2.71 0.77 0.90 1.12 121.15 5.52 2.50 +4WFF_B 188 Y 0.52 0.71 0.03 0.89 0.91 1.08 181.19 5.52 -1.30 +4WFF_B 189 M 0.52 0.87 -0.87 0.96 0.93 1.01 149.21 5.28 1.90 +4WFF_B 190 E 0.54 2.16 1.37 1.07 0.97 1.00 147.13 4.00 -3.50 +4WFF_B 191 D 0.52 2.76 1.99 1.05 1.00 0.93 133.10 3.80 -3.50 +4WFF_B 192 W 0.52 2.30 0.94 0.97 1.01 0.95 204.23 5.52 -0.90 +4WFF_B 193 S 0.49 2.30 2.66 0.99 1.02 0.95 105.09 5.24 -0.80 +4WFF_B 194 K 0.46 1.39 1.84 0.98 1.01 0.98 146.19 8.75 -3.90 +4WFF_B 195 L 0.42 0.93 -0.73 0.84 0.98 1.02 131.17 5.52 3.80 +4WFF_B 196 E 0.38 1.08 0.43 0.86 0.95 1.06 147.13 4.00 -3.50 +4WFF_B 197 A 0.33 0.47 -1.81 0.74 0.93 1.07 89.09 5.57 1.80 +4WFF_B 198 I 0.30 0.42 -3.16 0.67 0.90 1.14 131.17 5.52 4.50 +4WFF_B 199 Y 0.26 0.17 -2.99 0.65 0.89 1.12 181.19 5.52 -1.30 +4WFF_B 200 F 0.24 0.13 -4.63 0.62 0.89 1.20 165.19 5.52 2.80 +4WFF_B 201 V 0.22 0.26 -4.19 0.66 0.90 1.18 117.15 5.49 4.20 +4WFF_B 202 I 0.22 0.14 -4.36 0.68 0.91 1.19 131.17 5.52 4.50 +4WFF_B 203 V 0.22 0.23 -3.34 0.65 0.93 1.15 117.15 5.49 4.20 +4WFF_B 204 T 0.23 0.44 -1.29 0.71 0.95 1.13 119.12 5.19 -0.70 +4WFF_B 205 L 0.25 0.47 -1.29 0.71 0.98 1.13 131.17 5.52 3.80 +4WFF_B 206 T 0.28 0.62 0.67 0.86 1.00 1.09 119.12 5.19 -0.70 +4WFF_B 207 T 0.33 0.37 -0.11 0.88 1.00 1.05 119.12 5.19 -0.70 +4WFF_B 208 V 0.37 0.45 -0.04 0.96 0.99 1.04 117.15 5.49 4.20 +4WFF_B 209 G 0.41 0.52 2.70 1.09 0.98 0.99 75.07 5.52 -0.40 +4WFF_B 210 F 0.45 0.56 1.69 1.11 0.98 1.02 165.19 5.52 2.80 +4WFF_B 211 G 0.47 0.56 0.41 1.05 0.99 1.09 75.07 5.52 -0.40 +4WFF_B 212 D 0.49 0.58 1.24 1.07 0.99 1.04 133.10 3.80 -3.50 +4WFF_B 213 Y 0.51 0.66 1.24 1.07 0.97 1.04 181.19 5.52 -1.30 +4WFF_B 214 V 0.53 0.67 2.86 1.08 0.96 1.04 117.15 5.49 4.20 +4WFF_B 215 A 0.55 0.67 3.47 1.06 0.96 1.04 89.09 5.57 1.80 +4WFF_B 216 G 0.57 0.66 2.34 1.07 0.98 1.07 75.07 5.52 -0.40 +4WFF_B 217 A 0.59 1.75 3.21 1.04 1.01 1.03 89.09 5.57 1.80 +4WFF_B 218 D 0.60 3.00 4.60 1.11 1.04 0.97 133.10 3.80 -3.50 +4WFF_B 219 P 0.62 5.06 5.73 1.23 1.06 0.95 115.13 5.96 -1.60 +4WFF_B 220 R 0.64 6.71 5.84 1.21 1.08 0.97 174.20 9.75 -4.50 +4WFF_B 221 Q 0.65 6.21 5.84 1.33 1.09 0.97 146.15 5.52 -3.50 +4WFF_B 222 D 0.65 4.06 4.71 1.22 1.09 0.99 133.10 3.80 -3.50 +4WFF_B 223 S 0.63 3.25 4.14 1.16 1.08 1.01 105.09 5.24 -0.80 +4WFF_B 224 P 0.61 3.25 4.40 1.17 1.05 1.03 115.13 5.96 -1.60 +4WFF_B 225 A 0.57 3.01 3.84 1.24 1.02 1.04 89.09 5.57 1.80 +4WFF_B 226 Y 0.53 1.85 1.10 1.12 1.01 1.09 181.19 5.52 -1.30 +4WFF_B 227 Q 0.51 0.89 -0.36 0.99 1.00 1.14 146.15 5.52 -3.50 +4WFF_B 228 P 0.47 0.92 -2.09 0.91 0.98 1.12 115.13 5.96 -1.60 +4WFF_B 229 L 0.43 0.51 -3.70 0.90 0.96 1.12 131.17 5.52 3.80 +4WFF_B 230 V 0.39 0.31 -4.86 0.87 0.92 1.08 117.15 5.49 4.20 +4WFF_B 231 W 0.37 0.14 -6.86 0.80 0.89 1.10 204.23 5.52 -0.90 +4WFF_B 232 F 0.34 0.14 -8.47 0.67 0.87 1.13 165.19 5.52 2.80 +4WFF_B 233 W 0.32 0.16 -8.47 0.67 0.87 1.13 204.23 5.52 -0.90 +4WFF_B 234 I 0.30 0.15 -7.13 0.82 0.88 1.06 131.17 5.52 4.50 +4WFF_B 235 L 0.30 0.14 -7.01 0.77 0.91 1.11 131.17 5.52 3.80 +4WFF_B 236 L 0.31 0.13 -5.40 0.77 0.92 1.10 131.17 5.52 3.80 +4WFF_B 237 G 0.30 0.30 -4.24 0.80 0.92 1.14 75.07 5.52 -0.40 +4WFF_B 238 L 0.30 0.32 -4.41 0.82 0.92 1.13 131.17 5.52 3.80 +4WFF_B 239 A 0.30 0.39 -2.80 0.83 0.91 1.11 89.09 5.57 1.80 +4WFF_B 240 Y 0.31 0.52 -0.56 0.95 0.90 1.07 181.19 5.52 -1.30 +4WFF_B 241 F 0.32 0.47 -1.90 0.80 0.91 1.15 165.19 5.52 2.80 +4WFF_B 242 A 0.33 0.38 -1.90 0.80 0.92 1.15 89.09 5.57 1.80 +4WFF_B 243 S 0.35 0.35 -1.46 0.84 0.93 1.12 105.09 5.24 -0.80 +4WFF_B 244 V 0.35 0.59 -0.44 0.81 0.96 1.09 117.15 5.49 4.20 +4WFF_B 245 L 0.34 0.41 -0.27 0.80 0.98 1.10 131.17 5.52 3.80 +4WFF_B 246 T 0.35 0.30 0.24 0.92 1.00 1.07 119.12 5.19 -0.70 +4WFF_B 247 T 0.39 0.66 0.31 0.94 1.02 1.04 119.12 5.19 -0.70 +4WFF_B 248 I 0.39 0.84 -0.59 1.01 1.02 0.97 131.17 5.52 4.50 +4WFF_B 249 G 0.41 0.48 -0.59 1.01 1.01 0.97 75.07 5.52 -0.40 +4WFF_B 250 N 0.37 0.65 -0.73 1.01 0.00 0.96 132.12 5.52 -3.50 +4WFF_B 251 W 0.32 0.00 0.00 0.00 0.00 0.00 204.23 5.52 -0.90 +4WFF_B 252 L 0.28 0.00 0.00 0.00 0.00 0.00 131.17 5.52 3.80 +4WFF_B 253 R 0.23 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5BVP_A 1 V 0.22 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +5BVP_A 2 R 0.27 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5BVP_A 3 S 0.30 0.23 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +5BVP_A 4 L 0.33 0.45 1.63 1.03 0.98 1.09 131.17 5.52 3.80 +5BVP_A 5 N 0.39 0.19 0.84 1.04 0.97 1.07 132.12 5.52 -3.50 +5BVP_A 6 C 0.41 0.28 0.84 1.04 0.96 1.07 121.15 5.52 2.50 +5BVP_A 7 T 0.42 0.56 1.34 1.04 0.96 1.05 119.12 5.19 -0.70 +5BVP_A 8 L 0.42 0.47 3.59 1.16 0.99 1.01 131.17 5.52 3.80 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91 K 0.53 3.52 2.99 1.00 1.06 0.96 146.19 8.75 -3.90 +5BVP_A 92 K 0.52 4.56 4.07 0.99 1.06 0.92 146.19 8.75 -3.90 +5BVP_A 93 M 0.51 4.46 4.37 0.90 1.04 0.90 149.21 5.28 1.90 +5BVP_A 94 E 0.49 1.93 2.24 0.85 1.03 0.92 147.13 4.00 -3.50 +5BVP_A 95 K 0.47 0.72 0.90 0.77 1.02 0.98 146.19 8.75 -3.90 +5BVP_A 96 R 0.46 0.63 -1.23 0.71 0.99 1.01 174.20 9.75 -4.50 +5BVP_A 97 F 0.45 0.58 0.37 0.85 0.97 1.00 165.19 5.52 2.80 +5BVP_A 98 V 0.46 0.58 0.07 0.89 0.96 1.01 117.15 5.49 4.20 +5BVP_A 99 F 0.48 0.21 -1.89 0.81 0.96 1.04 165.19 5.52 2.80 +5BVP_A 100 N 0.49 0.42 -1.37 0.78 0.98 1.04 132.12 5.52 -3.50 +5BVP_A 101 K 0.49 0.39 -1.20 0.76 1.00 1.05 146.19 8.75 -3.90 +5BVP_A 102 I 0.51 0.73 0.33 0.92 1.00 0.96 131.17 5.52 4.50 +5BVP_A 103 E 0.54 0.73 2.64 1.05 1.00 0.92 147.13 4.00 -3.50 +5BVP_A 104 I 0.55 0.73 2.46 0.97 1.01 0.94 131.17 5.52 4.50 +5BVP_A 105 N 0.56 0.86 0.33 0.91 1.02 0.98 132.12 5.52 -3.50 +5BVP_A 106 N 0.54 0.86 2.59 0.95 1.03 0.94 132.12 5.52 -3.50 +5BVP_A 107 K 0.54 1.06 0.16 0.93 1.02 0.98 146.19 8.75 -3.90 +5BVP_A 108 L 0.52 1.15 2.41 0.97 1.00 0.93 131.17 5.52 3.80 +5BVP_A 109 E 0.50 0.95 2.34 0.95 0.99 0.97 147.13 4.00 -3.50 +5BVP_A 110 F 0.50 0.48 1.64 0.82 0.99 1.01 165.19 5.52 2.80 +5BVP_A 111 E 0.49 1.01 1.69 0.82 0.99 1.02 147.13 4.00 -3.50 +5BVP_A 112 S 0.47 0.51 1.69 0.82 0.99 1.00 105.09 5.24 -0.80 +5BVP_A 113 A 0.47 0.90 0.87 0.93 0.99 1.03 89.09 5.57 1.80 +5BVP_A 114 Q 0.44 0.84 3.19 1.07 0.99 0.98 146.15 5.52 -3.50 +5BVP_A 115 F 0.45 0.66 0.64 1.10 0.98 0.99 165.19 5.52 2.80 +5BVP_A 116 P 0.42 1.02 -0.56 1.06 0.98 1.01 115.13 5.96 -1.60 +5BVP_A 117 N 0.40 0.41 -2.00 1.03 0.96 1.02 132.12 5.52 -3.50 +5BVP_A 118 W 0.39 0.64 -1.93 1.10 0.95 1.02 204.23 5.52 -0.90 +5BVP_A 119 Y 0.38 0.60 0.13 1.15 0.94 1.00 181.19 5.52 -1.30 +5BVP_A 120 I 0.39 0.50 0.76 1.14 0.96 0.99 131.17 5.52 4.50 +5BVP_A 121 S 0.40 0.82 0.61 1.05 1.00 1.02 105.09 5.24 -0.80 +5BVP_A 122 T 0.41 0.53 2.34 1.01 1.04 1.05 119.12 5.19 -0.70 +5BVP_A 123 S 0.43 1.31 3.73 0.95 1.07 1.00 105.09 5.24 -0.80 +5BVP_A 124 Q 0.45 1.57 5.87 1.11 1.06 0.95 146.15 5.52 -3.50 +5BVP_A 125 A 0.47 1.07 4.34 0.99 1.05 0.92 89.09 5.57 1.80 +5BVP_A 126 E 0.48 1.24 3.90 1.07 1.02 0.94 147.13 4.00 -3.50 +5BVP_A 127 N 0.49 0.53 2.44 0.94 0.99 1.00 132.12 5.52 -3.50 +5BVP_A 128 M 0.47 0.46 0.27 0.88 0.97 1.01 149.21 5.28 1.90 +5BVP_A 129 P 0.45 0.22 -1.34 0.87 0.95 1.03 115.13 5.96 -1.60 +5BVP_A 130 V 0.45 0.13 -1.64 0.99 0.94 1.04 117.15 5.49 4.20 +5BVP_A 131 F 0.45 0.13 -1.83 0.99 0.96 1.05 165.19 5.52 2.80 +5BVP_A 132 L 0.45 0.09 -0.41 1.13 1.00 1.06 131.17 5.52 3.80 +5BVP_A 133 G 0.47 0.11 0.10 1.13 1.04 1.03 75.07 5.52 -0.40 +5BVP_A 134 G 0.48 0.23 1.49 1.20 1.09 0.98 75.07 5.52 -0.40 +5BVP_A 135 G 0.51 0.46 4.23 1.32 1.12 0.95 75.07 5.52 -0.40 +5BVP_A 136 G 0.52 0.33 4.40 1.31 1.12 0.93 75.07 5.52 -0.40 +5BVP_A 137 Q 0.55 0.48 4.33 1.22 1.11 0.94 146.15 5.52 -3.50 +5BVP_A 138 D 0.55 0.80 4.94 1.21 1.09 0.94 133.10 3.80 -3.50 +5BVP_A 139 I 0.53 0.70 2.81 1.07 1.06 0.97 131.17 5.52 4.50 +5BVP_A 140 T 0.51 0.59 2.74 0.98 1.04 0.97 119.12 5.19 -0.70 +5BVP_A 141 D 0.50 0.35 1.29 0.93 1.01 0.95 133.10 3.80 -3.50 +5BVP_A 142 F 0.49 0.86 0.71 0.86 0.98 0.97 165.19 5.52 2.80 +5BVP_A 143 T 0.48 0.52 0.54 0.88 0.95 0.96 119.12 5.19 -0.70 +5BVP_A 144 M 0.48 0.23 -0.73 0.81 0.93 1.03 149.21 5.28 1.90 +5BVP_A 145 Q 0.47 0.35 -1.23 0.81 0.93 1.05 146.15 5.52 -3.50 +5BVP_A 146 F 0.41 0.33 1.01 0.93 0.00 1.04 165.19 5.52 2.80 +5BVP_A 147 V 0.37 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +5BVP_A 148 S 0.33 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +5BVP_A 149 S 0.29 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4XAK_A 1 V 0.26 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +4XAK_A 2 E 0.31 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4XAK_A 3 C 0.37 0.34 0.00 0.00 0.00 0.00 121.15 5.52 2.50 +4XAK_A 4 D 0.43 0.71 2.13 1.06 0.96 1.10 133.10 3.80 -3.50 +4XAK_A 5 F 0.49 0.34 1.34 1.08 0.98 1.08 165.19 5.52 2.80 +4XAK_A 6 S 0.50 0.52 -1.09 1.05 1.00 1.13 105.09 5.24 -0.80 +4XAK_A 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0.97 1.03 117.15 5.49 4.20 +4XAK_A 24 F 0.51 0.17 -0.61 0.91 0.97 1.10 165.19 5.52 2.80 +4XAK_A 25 T 0.51 0.33 -0.21 0.99 0.97 1.09 119.12 5.19 -0.70 +4XAK_A 26 N 0.51 0.69 0.83 1.07 0.98 1.07 132.12 5.52 -3.50 +4XAK_A 27 C 0.51 1.29 2.36 1.22 0.97 0.99 121.15 5.52 2.50 +4XAK_A 28 N 0.52 0.74 2.36 1.22 0.96 1.01 132.12 5.52 -3.50 +4XAK_A 29 Y 0.54 0.66 2.36 1.22 0.96 1.01 181.19 5.52 -1.30 +4XAK_A 30 N 0.52 2.47 2.17 1.14 0.97 1.03 132.12 5.52 -3.50 +4XAK_A 31 L 0.52 1.27 0.66 1.06 0.99 1.01 131.17 5.52 3.80 +4XAK_A 32 T 0.53 0.67 -1.66 0.92 1.00 1.08 119.12 5.19 -0.70 +4XAK_A 33 K 0.53 0.56 -0.46 0.96 1.00 1.05 146.19 8.75 -3.90 +4XAK_A 34 L 0.51 0.56 -2.77 0.82 0.99 1.12 131.17 5.52 3.80 +4XAK_A 35 L 0.52 0.33 -2.77 0.82 0.97 1.10 131.17 5.52 3.80 +4XAK_A 36 S 0.51 0.22 -2.59 0.89 0.95 1.11 105.09 5.24 -0.80 +4XAK_A 37 L 0.51 0.20 -3.93 0.82 0.94 1.18 131.17 5.52 3.80 +4XAK_A 38 F 0.51 0.39 -1.61 0.96 0.94 1.11 165.19 5.52 2.80 +4XAK_A 39 S 0.52 0.49 1.13 1.08 0.96 1.06 105.09 5.24 -0.80 +4XAK_A 40 V 0.53 0.51 -1.11 0.96 0.98 1.07 117.15 5.49 4.20 +4XAK_A 41 N 0.52 0.85 0.94 1.02 0.99 1.02 132.12 5.52 -3.50 +4XAK_A 42 D 0.51 0.34 2.46 1.10 0.99 1.06 133.10 3.80 -3.50 +4XAK_A 43 F 0.52 0.62 2.46 1.10 0.98 1.06 165.19 5.52 2.80 +4XAK_A 44 T 0.51 0.66 3.84 1.17 0.98 1.01 119.12 5.19 -0.70 +4XAK_A 45 C 0.52 0.28 1.70 1.01 0.99 1.07 121.15 5.52 2.50 +4XAK_A 46 S 0.51 0.43 1.20 1.01 1.00 1.09 105.09 5.24 -0.80 +4XAK_A 47 Q 0.50 0.46 2.81 1.14 1.02 1.08 146.15 5.52 -3.50 +4XAK_A 48 I 0.51 0.87 2.37 1.10 1.03 1.10 131.17 5.52 4.50 +4XAK_A 49 S 0.49 0.66 2.47 1.02 1.02 1.05 105.09 5.24 -0.80 +4XAK_A 50 P 0.50 0.27 0.40 0.88 1.00 1.07 115.13 5.96 -1.60 +4XAK_A 51 A 0.51 0.38 -0.16 0.84 0.97 1.08 89.09 5.57 1.80 +4XAK_A 52 A 0.50 0.38 1.91 0.98 0.95 1.06 89.09 5.57 1.80 +4XAK_A 53 I 0.50 0.40 1.99 0.99 0.94 1.03 131.17 5.52 4.50 +4XAK_A 54 A 0.48 0.21 1.89 0.95 0.95 1.08 89.09 5.57 1.80 +4XAK_A 55 S 0.47 0.33 1.31 1.02 0.96 1.09 105.09 5.24 -0.80 +4XAK_A 56 N 0.46 0.63 1.94 1.13 0.97 1.08 132.12 5.52 -3.50 +4XAK_A 57 C 0.43 0.83 4.01 1.26 0.97 1.06 121.15 5.52 2.50 +4XAK_A 58 Y 0.44 0.51 2.40 1.25 0.98 1.09 181.19 5.52 -1.30 +4XAK_A 59 S 0.42 0.22 0.33 1.12 0.98 1.11 105.09 5.24 -0.80 +4XAK_A 60 S 0.41 0.34 -1.99 0.98 0.98 1.18 105.09 5.24 -0.80 +4XAK_A 61 L 0.40 0.37 -0.76 1.02 0.97 1.10 131.17 5.52 3.80 +4XAK_A 62 I 0.40 0.43 -0.76 1.02 0.95 1.10 131.17 5.52 4.50 +4XAK_A 63 L 0.41 0.28 -3.00 0.90 0.94 1.11 131.17 5.52 3.80 +4XAK_A 64 D 0.41 0.45 -3.00 0.90 0.93 1.11 133.10 3.80 -3.50 +4XAK_A 65 Y 0.43 1.00 -1.96 0.98 0.93 1.10 181.19 5.52 -1.30 +4XAK_A 66 F 0.47 1.88 -0.51 1.13 0.93 1.09 165.19 5.52 2.80 +4XAK_A 67 S 0.49 0.93 -0.51 1.13 0.93 1.09 105.09 5.24 -0.80 +4XAK_A 68 Y 0.53 0.80 -1.01 1.12 0.94 1.11 181.19 5.52 -1.30 +4XAK_A 69 P 0.55 0.91 -1.34 1.04 0.94 1.06 115.13 5.96 -1.60 +4XAK_A 70 L 0.57 1.36 0.79 1.10 0.95 1.04 131.17 5.52 3.80 +4XAK_A 71 S 0.59 1.16 0.79 1.10 0.97 1.04 105.09 5.24 -0.80 +4XAK_A 72 M 0.58 1.25 2.49 1.15 1.01 0.99 149.21 5.28 1.90 +4XAK_A 73 K 0.61 1.25 0.87 1.02 1.04 1.02 146.19 8.75 -3.90 +4XAK_A 74 S 0.62 1.25 3.11 1.14 1.05 0.99 105.09 5.24 -0.80 +4XAK_A 75 D 0.62 0.94 1.66 1.00 1.04 1.04 133.10 3.80 -3.50 +4XAK_A 76 L 0.62 0.63 3.19 1.12 1.02 1.07 131.17 5.52 3.80 +4XAK_A 77 S 0.62 0.63 3.30 1.18 1.00 1.08 105.09 5.24 -0.80 +4XAK_A 78 V 0.61 0.38 2.67 1.07 1.00 1.09 117.15 5.49 4.20 +4XAK_A 79 S 0.60 0.46 2.06 1.09 1.01 1.09 105.09 5.24 -0.80 +4XAK_A 80 S 0.59 0.53 3.67 1.22 1.03 1.06 105.09 5.24 -0.80 +4XAK_A 81 A 0.61 0.50 1.60 1.08 1.04 1.08 89.09 5.57 1.80 +4XAK_A 82 G 0.60 0.50 3.06 1.21 1.05 1.03 75.07 5.52 -0.40 +4XAK_A 83 P 0.60 0.64 2.99 1.15 1.05 1.03 115.13 5.96 -1.60 +4XAK_A 84 I 0.60 0.55 0.74 1.03 1.03 1.04 131.17 5.52 4.50 +4XAK_A 85 S 0.58 0.90 1.44 1.16 1.02 1.00 105.09 5.24 -0.80 +4XAK_A 86 Q 0.58 0.91 0.36 1.10 1.00 1.04 146.15 5.52 -3.50 +4XAK_A 87 F 0.58 2.59 0.87 1.03 0.98 1.02 165.19 5.52 2.80 +4XAK_A 88 N 0.60 3.35 2.87 1.10 0.99 1.00 132.12 5.52 -3.50 +4XAK_A 89 Y 0.62 2.59 2.87 1.10 1.01 1.00 181.19 5.52 -1.30 +4XAK_A 90 K 0.62 2.59 0.70 1.05 1.03 1.01 146.19 8.75 -3.90 +4XAK_A 91 Q 0.60 2.16 2.94 1.16 1.05 1.00 146.15 5.52 -3.50 +4XAK_A 92 S 0.59 2.22 2.94 1.16 1.05 1.00 105.09 5.24 -0.80 +4XAK_A 93 F 0.57 1.71 3.51 1.22 1.04 0.99 165.19 5.52 2.80 +4XAK_A 94 S 0.54 1.43 3.44 1.21 1.05 0.98 105.09 5.24 -0.80 +4XAK_A 95 N 0.50 0.57 2.79 1.24 1.04 1.04 132.12 5.52 -3.50 +4XAK_A 96 P 0.46 0.54 0.54 1.12 1.03 1.07 115.13 5.96 -1.60 +4XAK_A 97 T 0.42 0.28 0.71 1.10 1.00 1.08 119.12 5.19 -0.70 +4XAK_A 98 C 0.36 0.15 -1.53 0.98 0.96 1.12 121.15 5.52 2.50 +4XAK_A 99 L 0.33 0.10 -2.23 0.85 0.93 1.16 131.17 5.52 3.80 +4XAK_A 100 I 0.31 0.10 -1.79 0.77 0.92 1.14 131.17 5.52 4.50 +4XAK_A 101 L 0.32 0.13 -3.06 0.71 0.92 1.20 131.17 5.52 3.80 +4XAK_A 102 A 0.34 0.25 -2.96 0.76 0.93 1.15 89.09 5.57 1.80 +4XAK_A 103 T 0.37 0.48 -1.34 0.81 0.94 1.13 119.12 5.19 -0.70 +4XAK_A 104 V 0.40 0.94 0.80 0.96 0.95 1.08 117.15 5.49 4.20 +4XAK_A 105 P 0.44 0.76 0.80 0.96 0.95 1.08 115.13 5.96 -1.60 +4XAK_A 106 H 0.46 0.76 1.24 1.01 0.96 1.06 155.16 6.74 -3.20 +4XAK_A 107 N 0.48 1.49 1.24 1.01 0.97 1.06 132.12 5.52 -3.50 +4XAK_A 108 L 0.50 0.67 0.63 1.00 0.99 1.02 131.17 5.52 3.80 +4XAK_A 109 T 0.53 0.72 1.07 0.92 1.01 1.00 119.12 5.19 -0.70 +4XAK_A 110 T 0.54 0.89 1.59 0.93 1.03 0.98 119.12 5.19 -0.70 +4XAK_A 111 I 0.55 1.67 0.89 0.92 1.04 1.02 131.17 5.52 4.50 +4XAK_A 112 T 0.55 0.95 0.89 0.92 1.05 1.02 119.12 5.19 -0.70 +4XAK_A 113 K 0.56 1.32 0.96 0.93 1.05 1.02 146.19 8.75 -3.90 +4XAK_A 114 P 0.56 2.95 -0.06 0.96 1.04 1.06 115.13 5.96 -1.60 +4XAK_A 115 L 0.57 2.74 2.01 1.09 1.02 1.04 131.17 5.52 3.80 +4XAK_A 116 K 0.59 2.15 1.00 1.12 1.00 1.07 146.19 8.75 -3.90 +4XAK_A 117 Y 0.60 0.97 -0.96 1.04 0.97 1.10 181.19 5.52 -1.30 +4XAK_A 118 S 0.61 1.90 -0.26 1.05 0.95 1.06 105.09 5.24 -0.80 +4XAK_A 119 Y 0.60 1.90 1.87 1.11 0.95 1.02 181.19 5.52 -1.30 +4XAK_A 120 I 0.59 0.65 1.26 1.13 0.96 1.09 131.17 5.52 4.50 +4XAK_A 121 N 0.59 0.65 2.46 1.18 0.98 1.06 132.12 5.52 -3.50 +4XAK_A 122 K 0.59 0.81 2.13 1.11 1.00 1.05 146.19 8.75 -3.90 +4XAK_A 123 C 0.60 1.00 1.09 1.03 1.01 1.04 121.15 5.52 2.50 +4XAK_A 124 S 0.60 0.51 0.91 1.05 1.01 1.05 105.09 5.24 -0.80 +4XAK_A 125 R 0.61 0.34 0.84 1.03 1.00 1.08 174.20 9.75 -4.50 +4XAK_A 126 F 0.62 1.07 1.46 1.09 0.99 1.07 165.19 5.52 2.80 +4XAK_A 127 L 0.62 1.34 2.69 1.13 1.00 1.00 131.17 5.52 3.80 +4XAK_A 128 S 0.63 1.34 2.36 1.06 1.01 0.98 105.09 5.24 -0.80 +4XAK_A 129 D 0.63 2.23 2.50 1.06 1.02 0.98 133.10 3.80 -3.50 +4XAK_A 130 D 0.62 4.68 4.93 1.08 1.04 0.95 133.10 3.80 -3.50 +4XAK_A 131 R 0.61 2.59 5.71 1.07 1.04 0.97 174.20 9.75 -4.50 +4XAK_A 132 T 0.59 2.40 5.09 1.08 1.04 0.97 119.12 5.19 -0.70 +4XAK_A 133 E 0.58 2.49 4.51 1.02 1.04 0.99 147.13 4.00 -3.50 +4XAK_A 134 V 0.56 1.05 1.77 0.89 1.03 1.05 117.15 5.49 4.20 +4XAK_A 135 P 0.53 0.54 0.64 0.83 1.02 1.12 115.13 5.96 -1.60 +4XAK_A 136 Q 0.51 0.50 0.90 0.91 1.00 1.10 146.15 5.52 -3.50 +4XAK_A 137 L 0.51 0.68 0.09 0.90 0.99 1.13 131.17 5.52 3.80 +4XAK_A 138 V 0.52 0.71 1.61 1.05 0.98 1.05 117.15 5.49 4.20 +4XAK_A 139 N 0.52 0.71 2.17 0.98 0.98 1.04 132.12 5.52 -3.50 +4XAK_A 140 A 0.52 1.35 1.04 1.00 0.99 1.06 89.09 5.57 1.80 +4XAK_A 141 N 0.52 2.43 3.29 1.12 1.00 1.03 132.12 5.52 -3.50 +4XAK_A 142 Q 0.52 2.34 4.11 1.26 1.01 0.98 146.15 5.52 -3.50 +4XAK_A 143 Y 0.53 1.24 3.31 1.21 1.01 1.07 181.19 5.52 -1.30 +4XAK_A 144 S 0.54 0.57 2.49 1.19 1.00 1.12 105.09 5.24 -0.80 +4XAK_A 145 P 0.54 0.44 2.41 1.17 0.99 1.15 115.13 5.96 -1.60 +4XAK_A 146 C 0.54 0.20 0.41 1.10 0.96 1.17 121.15 5.52 2.50 +4XAK_A 147 V 0.54 0.11 0.16 1.01 0.94 1.20 117.15 5.49 4.20 +4XAK_A 148 S 0.54 0.11 -0.47 1.02 0.93 1.21 105.09 5.24 -0.80 +4XAK_A 149 I 0.55 0.27 0.16 1.01 0.95 1.20 131.17 5.52 4.50 +4XAK_A 150 V 0.55 0.53 0.70 0.97 0.99 1.13 117.15 5.49 4.20 +4XAK_A 151 P 0.58 0.30 0.70 0.97 1.02 1.13 115.13 5.96 -1.60 +4XAK_A 152 S 0.57 0.44 -1.66 0.91 1.04 1.11 105.09 5.24 -0.80 +4XAK_A 153 T 0.58 1.03 0.60 0.94 1.03 1.07 119.12 5.19 -0.70 +4XAK_A 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0.37 1.11 1.21 1.07 0.95 75.07 5.52 -0.40 +4XAK_A 171 G 0.53 0.37 -0.50 1.08 1.06 0.98 75.07 5.52 -0.40 +4XAK_A 172 G 0.51 0.16 0.29 1.07 1.03 1.00 75.07 5.52 -0.40 +4XAK_A 173 W 0.49 0.16 -0.53 1.06 0.98 1.03 204.23 5.52 -0.90 +4XAK_A 174 L 0.47 0.22 -0.41 1.04 0.96 1.05 131.17 5.52 3.80 +4XAK_A 175 V 0.48 0.22 -0.41 1.04 0.96 1.05 117.15 5.49 4.20 +4XAK_A 176 A 0.47 0.28 -0.30 1.02 0.99 1.07 89.09 5.57 1.80 +4XAK_A 177 S 0.48 0.49 1.87 1.02 1.04 1.07 105.09 5.24 -0.80 +4XAK_A 178 G 0.48 0.49 2.66 1.01 1.07 1.09 75.07 5.52 -0.40 +4XAK_A 179 S 0.48 0.49 3.49 1.03 1.07 1.05 105.09 5.24 -0.80 +4XAK_A 180 T 0.51 0.36 2.59 1.02 1.03 1.01 119.12 5.19 -0.70 +4XAK_A 181 V 0.53 0.53 2.40 0.95 0.99 1.00 117.15 5.49 4.20 +4XAK_A 182 A 0.54 0.69 2.70 0.84 0.96 0.99 89.09 5.57 1.80 +4XAK_A 183 M 0.54 0.82 2.63 0.77 0.96 0.99 149.21 5.28 1.90 +4XAK_A 184 T 0.54 0.91 0.57 0.72 0.99 1.04 119.12 5.19 -0.70 +4XAK_A 185 E 0.54 1.57 1.96 0.79 1.00 0.99 147.13 4.00 -3.50 +4XAK_A 186 Q 0.51 1.57 1.06 0.78 1.00 0.96 146.15 5.52 -3.50 +4XAK_A 187 L 0.49 1.07 2.47 0.92 0.98 0.96 131.17 5.52 3.80 +4XAK_A 188 Q 0.46 0.54 0.41 0.86 0.95 0.99 146.15 5.52 -3.50 +4XAK_A 189 M 0.43 0.31 0.11 0.98 0.93 0.99 149.21 5.28 1.90 +4XAK_A 190 G 0.40 0.26 -1.89 0.91 0.93 1.01 75.07 5.52 -0.40 +4XAK_A 191 F 0.37 0.22 0.17 0.96 0.94 0.96 165.19 5.52 2.80 +4XAK_A 192 G 0.36 0.16 -1.21 0.89 0.95 1.02 75.07 5.52 -0.40 +4XAK_A 193 I 0.35 0.29 0.24 0.95 0.95 1.04 131.17 5.52 4.50 +4XAK_A 194 T 0.35 0.52 -0.84 0.89 0.95 1.08 119.12 5.19 -0.70 +4XAK_A 195 V 0.39 0.52 1.29 1.02 0.95 1.05 117.15 5.49 4.20 +4XAK_A 196 Q 0.43 1.06 1.21 0.94 0.96 1.06 146.15 5.52 -3.50 +4XAK_A 197 Y 0.46 1.06 3.10 1.01 0.98 1.02 181.19 5.52 -1.30 +4XAK_A 198 G 0.49 2.30 3.36 1.09 1.02 1.00 75.07 5.52 -0.40 +4XAK_A 199 T 0.51 1.78 4.81 1.23 1.05 0.95 119.12 5.19 -0.70 +4XAK_A 200 T 0.52 0.84 3.43 1.16 1.06 1.00 119.12 5.19 -0.70 +4XAK_A 201 N 0.54 0.46 3.90 1.17 1.05 1.04 132.12 5.52 -3.50 +4XAK_A 202 S 0.55 0.49 3.39 1.16 1.02 1.07 105.09 5.24 -0.80 +4XAK_A 203 V 0.56 0.68 3.46 1.17 1.00 1.07 117.15 5.49 4.20 +4XAK_A 204 C 0.56 0.35 1.40 1.11 0.99 1.12 121.15 5.52 2.50 +4XAK_A 205 P 0.54 0.45 1.51 1.00 1.00 1.13 115.13 5.96 -1.60 +4XAK_A 206 K 0.54 0.52 -0.73 0.88 1.00 1.14 146.19 8.75 -3.90 +4XAK_A 207 L 0.48 0.99 0.10 0.90 0.00 1.09 131.17 5.52 3.80 +4XAK_A 208 E 0.42 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4XAK_A 209 F 0.38 0.00 0.00 0.00 0.00 0.00 165.19 5.52 2.80 +4XAK_A 210 A 0.32 0.00 0.00 0.00 0.00 0.00 89.09 5.57 1.80 +4WFF_A 1 R 0.18 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_A 2 S 0.22 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4WFF_A 3 T 0.27 1.31 0.00 0.00 0.00 0.00 119.12 5.19 -0.70 +4WFF_A 4 T 0.29 0.67 0.69 0.88 1.03 1.04 119.12 5.19 -0.70 +4WFF_A 5 L 0.31 0.42 -1.23 0.83 0.99 1.09 131.17 5.52 3.80 +4WFF_A 6 L 0.31 0.24 -3.47 0.71 0.95 1.13 131.17 5.52 3.80 +4WFF_A 7 A 0.30 0.17 -3.91 0.66 0.93 1.15 89.09 5.57 1.80 +4WFF_A 8 L 0.29 0.17 -5.97 0.61 0.91 1.20 131.17 5.52 3.80 +4WFF_A 9 L 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0.96 133.10 3.80 -3.50 +4WFF_A 108 A 0.46 1.37 3.17 1.02 1.05 0.96 89.09 5.57 1.80 +4WFF_A 109 G 0.43 0.82 1.26 0.97 1.03 0.99 75.07 5.52 -0.40 +4WFF_A 110 R 0.39 0.26 0.71 1.00 1.00 1.06 174.20 9.75 -4.50 +4WFF_A 111 L 0.37 0.18 -1.86 0.86 0.97 1.10 131.17 5.52 3.80 +4WFF_A 112 F 0.36 0.16 -3.47 0.85 0.94 1.11 165.19 5.52 2.80 +4WFF_A 113 C 0.33 0.13 -4.56 0.79 0.92 1.15 121.15 5.52 2.50 +4WFF_A 114 I 0.32 0.16 -4.86 0.75 0.90 1.17 131.17 5.52 4.50 +4WFF_A 115 F 0.30 0.15 -4.86 0.75 0.89 1.17 165.19 5.52 2.80 +4WFF_A 116 Y 0.29 0.21 -4.07 0.74 0.89 1.22 181.19 5.52 -1.30 +4WFF_A 117 A 0.28 0.29 -3.46 0.79 0.89 1.14 89.09 5.57 1.80 +4WFF_A 118 L 0.30 0.24 -3.46 0.79 0.91 1.14 131.17 5.52 3.80 +4WFF_A 119 V 0.31 0.23 -1.84 0.92 0.92 1.14 117.15 5.49 4.20 +4WFF_A 120 G 0.32 0.19 -2.89 0.84 0.94 1.15 75.07 5.52 -0.40 +4WFF_A 121 I 0.31 0.20 -4.50 0.83 0.95 1.15 131.17 5.52 4.50 +4WFF_A 122 P 0.33 0.27 -2.37 0.97 0.95 1.10 115.13 5.96 -1.60 +4WFF_A 123 L 0.33 0.19 -2.99 0.97 0.94 1.07 131.17 5.52 3.80 +4WFF_A 124 F 0.33 0.22 -5.11 0.83 0.93 1.12 165.19 5.52 2.80 +4WFF_A 125 G 0.33 0.12 -5.29 0.85 0.92 1.13 75.07 5.52 -0.40 +4WFF_A 126 I 0.35 0.15 -5.29 0.72 0.92 1.13 131.17 5.52 4.50 +4WFF_A 127 L 0.35 0.17 -3.16 0.86 0.92 1.08 131.17 5.52 3.80 +4WFF_A 128 L 0.36 0.12 -2.37 0.85 0.93 1.12 131.17 5.52 3.80 +4WFF_A 129 A 0.39 0.18 -2.37 0.85 0.94 1.12 89.09 5.57 1.80 +4WFF_A 130 G 0.42 0.36 0.20 0.99 0.96 1.08 75.07 5.52 -0.40 +4WFF_A 131 V 0.44 0.85 2.11 1.04 0.98 1.03 117.15 5.49 4.20 +4WFF_A 132 G 0.46 0.69 2.11 1.04 1.00 1.03 75.07 5.52 -0.40 +4WFF_A 133 D 0.47 0.69 2.63 1.17 1.01 1.00 133.10 3.80 -3.50 +4WFF_A 134 R 0.49 1.25 2.74 1.15 1.03 1.02 174.20 9.75 -4.50 +4WFF_A 135 L 0.50 1.69 4.20 1.28 1.04 0.97 131.17 5.52 3.80 +4WFF_A 136 G 0.52 0.83 2.07 1.14 1.05 1.02 75.07 5.52 -0.40 +4WFF_A 137 S 0.53 0.83 1.24 1.07 1.05 1.02 105.09 5.24 -0.80 +4WFF_A 138 S 0.52 1.37 0.94 1.07 1.03 1.05 105.09 5.24 -0.80 +4WFF_A 139 L 0.52 1.37 3.07 1.21 1.00 1.00 131.17 5.52 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204 T 0.33 0.38 -0.11 0.88 1.00 1.05 119.12 5.19 -0.70 +4WFF_A 205 V 0.37 0.46 -0.04 0.96 0.99 1.04 117.15 5.49 4.20 +4WFF_A 206 G 0.40 0.53 2.70 1.09 0.98 0.99 75.07 5.52 -0.40 +4WFF_A 207 F 0.43 0.58 1.69 1.11 0.98 1.02 165.19 5.52 2.80 +4WFF_A 208 G 0.46 0.58 0.41 1.05 0.99 1.09 75.07 5.52 -0.40 +4WFF_A 209 D 0.48 0.59 1.24 1.07 0.99 1.04 133.10 3.80 -3.50 +4WFF_A 210 Y 0.50 0.68 1.24 1.07 0.97 1.04 181.19 5.52 -1.30 +4WFF_A 211 V 0.52 0.69 2.86 1.08 0.96 1.04 117.15 5.49 4.20 +4WFF_A 212 A 0.55 0.69 3.47 1.06 0.96 1.04 89.09 5.57 1.80 +4WFF_A 213 G 0.57 0.68 2.34 1.07 0.98 1.07 75.07 5.52 -0.40 +4WFF_A 214 A 0.59 1.80 3.21 1.04 1.01 1.03 89.09 5.57 1.80 +4WFF_A 215 D 0.61 3.08 4.60 1.11 1.04 0.97 133.10 3.80 -3.50 +4WFF_A 216 P 0.61 5.20 5.73 1.23 1.06 0.95 115.13 5.96 -1.60 +4WFF_A 217 R 0.63 6.90 5.84 1.21 1.08 0.97 174.20 9.75 -4.50 +4WFF_A 218 Q 0.64 6.39 5.84 1.33 1.09 0.97 146.15 5.52 -3.50 +4WFF_A 219 D 0.63 4.17 4.71 1.22 1.09 0.99 133.10 3.80 -3.50 +4WFF_A 220 S 0.62 3.34 4.14 1.16 1.08 1.01 105.09 5.24 -0.80 +4WFF_A 221 P 0.60 3.34 4.40 1.17 1.05 1.03 115.13 5.96 -1.60 +4WFF_A 222 A 0.57 3.09 3.84 1.24 1.02 1.04 89.09 5.57 1.80 +4WFF_A 223 Y 0.53 1.90 1.10 1.12 1.01 1.09 181.19 5.52 -1.30 +4WFF_A 224 Q 0.50 0.91 -0.36 0.99 1.00 1.14 146.15 5.52 -3.50 +4WFF_A 225 P 0.47 0.95 -2.09 0.91 0.98 1.12 115.13 5.96 -1.60 +4WFF_A 226 L 0.44 0.53 -3.70 0.90 0.96 1.12 131.17 5.52 3.80 +4WFF_A 227 V 0.40 0.32 -4.86 0.87 0.92 1.08 117.15 5.49 4.20 +4WFF_A 228 W 0.37 0.14 -6.86 0.80 0.89 1.10 204.23 5.52 -0.90 +4WFF_A 229 F 0.34 0.14 -8.47 0.67 0.87 1.13 165.19 5.52 2.80 +4WFF_A 230 W 0.32 0.16 -8.47 0.67 0.87 1.13 204.23 5.52 -0.90 +4WFF_A 231 I 0.30 0.15 -7.13 0.82 0.88 1.06 131.17 5.52 4.50 +4WFF_A 232 L 0.30 0.14 -7.01 0.77 0.91 1.11 131.17 5.52 3.80 +4WFF_A 233 L 0.31 0.14 -5.40 0.77 0.92 1.10 131.17 5.52 3.80 +4WFF_A 234 G 0.31 0.31 -4.24 0.80 0.92 1.14 75.07 5.52 -0.40 +4WFF_A 235 L 0.30 0.32 -4.41 0.82 0.92 1.13 131.17 5.52 3.80 +4WFF_A 236 A 0.31 0.40 -2.80 0.83 0.91 1.11 89.09 5.57 1.80 +4WFF_A 237 Y 0.31 0.54 -0.56 0.95 0.90 1.07 181.19 5.52 -1.30 +4WFF_A 238 F 0.33 0.48 -1.90 0.80 0.91 1.15 165.19 5.52 2.80 +4WFF_A 239 A 0.35 0.40 -1.90 0.80 0.92 1.15 89.09 5.57 1.80 +4WFF_A 240 S 0.37 0.36 -1.46 0.84 0.93 1.12 105.09 5.24 -0.80 +4WFF_A 241 V 0.36 0.61 -0.44 0.81 0.96 1.09 117.15 5.49 4.20 +4WFF_A 242 L 0.34 0.42 -0.27 0.80 0.98 1.10 131.17 5.52 3.80 +4WFF_A 243 T 0.37 0.31 0.24 0.92 1.00 1.07 119.12 5.19 -0.70 +4WFF_A 244 T 0.40 0.67 0.31 0.94 1.02 1.04 119.12 5.19 -0.70 +4WFF_A 245 I 0.40 0.86 -0.59 1.01 1.02 0.97 131.17 5.52 4.50 +4WFF_A 246 G 0.42 0.49 -0.59 1.01 1.01 0.97 75.07 5.52 -0.40 +4WFF_A 247 N 0.43 0.67 -0.73 1.01 0.99 0.96 132.12 5.52 -3.50 +4WFF_A 248 W 0.43 0.71 -2.00 0.94 0.96 1.03 204.23 5.52 -0.90 +4WFF_A 249 L 0.37 0.53 -1.39 0.95 0.00 1.06 131.17 5.52 3.80 +4WFF_A 250 R 0.34 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +4WFF_A 251 V 0.30 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +4WFF_A 252 V 0.25 0.00 0.00 0.00 0.00 0.00 117.15 5.49 4.20 +5C0N_A 1 C 0.25 0.00 0.00 0.00 0.00 0.00 121.15 5.52 2.50 +5C0N_A 2 D 0.31 0.00 0.00 0.00 0.00 0.00 133.10 3.80 -3.50 +5C0N_A 3 A 0.35 0.12 0.00 0.00 0.00 0.00 89.09 5.57 1.80 +5C0N_A 4 F 0.42 0.32 1.64 0.99 0.95 1.09 165.19 5.52 2.80 +5C0N_A 5 V 0.47 0.20 0.01 0.96 0.96 1.01 117.15 5.49 4.20 +5C0N_A 6 G 0.48 0.40 -0.60 0.89 0.99 1.02 75.07 5.52 -0.40 +5C0N_A 7 T 0.49 0.38 -2.21 0.88 1.00 1.05 119.12 5.19 -0.70 +5C0N_A 8 W 0.51 0.38 -1.43 0.87 0.99 1.09 204.23 5.52 -0.90 +5C0N_A 9 K 0.52 0.52 0.03 1.00 1.00 1.04 146.19 8.75 -3.90 +5C0N_A 10 L 0.52 0.48 0.14 0.98 1.00 1.06 131.17 5.52 3.80 +5C0N_A 11 V 0.54 0.79 0.51 0.95 1.01 1.05 117.15 5.49 4.20 +5C0N_A 12 S 0.55 0.64 2.94 1.04 1.04 1.03 105.09 5.24 -0.80 +5C0N_A 13 S 0.56 0.67 0.81 0.98 1.05 1.05 105.09 5.24 -0.80 +5C0N_A 14 E 0.56 1.51 3.56 1.10 1.05 1.00 147.13 4.00 -3.50 +5C0N_A 15 N 0.57 1.88 5.51 1.24 1.05 0.92 132.12 5.52 -3.50 +5C0N_A 16 F 0.56 2.20 4.31 1.20 1.03 0.95 165.19 5.52 2.80 +5C0N_A 17 D 0.55 1.26 2.79 1.08 1.02 0.92 133.10 3.80 -3.50 +5C0N_A 18 D 0.55 1.56 2.49 1.12 1.01 0.93 133.10 3.80 -3.50 +5C0N_A 19 Y 0.54 3.13 2.60 1.00 0.99 0.94 181.19 5.52 -1.30 +5C0N_A 20 M 0.54 1.39 3.39 0.99 0.99 0.98 149.21 5.28 1.90 +5C0N_A 21 K 0.53 0.82 2.77 1.00 0.99 0.98 146.19 8.75 -3.90 +5C0N_A 22 E 0.53 0.39 0.81 0.86 0.99 1.06 147.13 4.00 -3.50 +5C0N_A 23 V 0.53 0.39 1.90 0.92 0.98 1.02 117.15 5.49 4.20 +5C0N_A 24 G 0.53 0.17 1.19 0.92 0.97 1.06 75.07 5.52 -0.40 +5C0N_A 25 V 0.54 0.10 0.67 0.87 0.95 1.07 117.15 5.49 4.20 +5C0N_A 26 G 0.54 0.19 0.30 0.91 0.95 1.08 75.07 5.52 -0.40 +5C0N_A 27 F 0.54 0.38 1.43 0.97 0.96 1.01 165.19 5.52 2.80 +5C0N_A 28 A 0.53 1.02 1.43 0.89 0.98 1.02 89.09 5.57 1.80 +5C0N_A 29 T 0.51 0.77 1.43 0.89 1.00 1.02 119.12 5.19 -0.70 +5C0N_A 30 R 0.52 0.89 0.91 0.76 1.01 1.04 174.20 9.75 -4.50 +5C0N_A 31 K 0.51 0.88 3.04 0.90 1.01 1.01 146.19 8.75 -3.90 +5C0N_A 32 V 0.50 0.60 2.14 0.89 0.98 0.98 117.15 5.49 4.20 +5C0N_A 33 A 0.50 0.31 1.70 0.85 0.95 1.00 89.09 5.57 1.80 +5C0N_A 34 G 0.50 0.31 1.91 0.86 0.94 1.01 75.07 5.52 -0.40 +5C0N_A 35 M 0.49 0.65 1.40 0.93 0.94 1.03 149.21 5.28 1.90 +5C0N_A 36 A 0.47 1.03 2.93 1.08 0.97 0.94 89.09 5.57 1.80 +5C0N_A 37 K 0.46 1.03 2.03 1.07 0.99 0.91 146.19 8.75 -3.90 +5C0N_A 38 P 0.45 0.73 0.07 0.92 0.99 0.95 115.13 5.96 -1.60 +5C0N_A 39 N 0.44 0.50 -0.47 0.90 0.97 0.99 132.12 5.52 -3.50 +5C0N_A 40 M 0.43 0.34 0.16 1.01 0.94 0.99 149.21 5.28 1.90 +5C0N_A 41 I 0.44 0.16 -1.19 0.94 0.92 1.05 131.17 5.52 4.50 +5C0N_A 42 I 0.43 0.16 -0.49 0.94 0.92 1.01 131.17 5.52 4.50 +5C0N_A 43 S 0.44 0.16 -0.67 0.94 0.94 1.02 105.09 5.24 -0.80 +5C0N_A 44 V 0.45 0.39 1.36 1.06 0.98 1.03 117.15 5.49 4.20 +5C0N_A 45 N 0.46 0.46 1.19 1.08 1.02 1.04 132.12 5.52 -3.50 +5C0N_A 46 G 0.45 0.25 1.80 1.09 1.04 1.08 75.07 5.52 -0.40 +5C0N_A 47 D 0.46 0.49 1.61 1.02 1.03 1.06 133.10 3.80 -3.50 +5C0N_A 48 L 0.46 0.21 1.00 1.01 1.00 1.03 131.17 5.52 3.80 +5C0N_A 49 V 0.46 0.42 0.60 0.93 0.98 1.04 117.15 5.49 4.20 +5C0N_A 50 T 0.45 0.34 0.71 0.91 0.98 1.06 119.12 5.19 -0.70 +5C0N_A 51 I 0.45 0.71 0.40 0.81 1.01 1.06 131.17 5.52 4.50 +5C0N_A 52 R 0.44 1.29 2.64 0.93 1.05 1.03 174.20 9.75 -4.50 +5C0N_A 53 S 0.45 1.29 3.91 0.99 1.09 0.96 105.09 5.24 -0.80 +5C0N_A 54 E 0.47 1.59 1.86 0.94 1.09 0.99 147.13 4.00 -3.50 +5C0N_A 55 S 0.48 1.62 3.81 1.02 1.09 0.95 105.09 5.24 -0.80 +5C0N_A 56 T 0.50 1.95 4.21 1.10 1.07 0.94 119.12 5.19 -0.70 +5C0N_A 57 F 0.51 1.62 4.03 1.04 1.05 0.93 165.19 5.52 2.80 +5C0N_A 58 K 0.51 2.10 4.03 1.04 1.06 0.93 146.19 8.75 -3.90 +5C0N_A 59 N 0.50 1.02 1.96 0.90 1.06 0.95 132.12 5.52 -3.50 +5C0N_A 60 T 0.49 1.58 2.14 0.97 1.05 0.96 119.12 5.19 -0.70 +5C0N_A 61 E 0.48 0.68 2.14 0.97 1.03 0.96 147.13 4.00 -3.50 +5C0N_A 62 I 0.48 0.85 2.14 0.97 1.00 0.96 131.17 5.52 4.50 +5C0N_A 63 S 0.47 0.49 -0.17 0.83 0.98 1.03 105.09 5.24 -0.80 +5C0N_A 64 F 0.46 0.28 -0.10 0.91 0.97 1.02 165.19 5.52 2.80 +5C0N_A 65 K 0.47 0.29 -1.74 0.88 0.97 1.10 146.19 8.75 -3.90 +5C0N_A 66 L 0.47 0.38 0.51 0.92 0.97 1.06 131.17 5.52 3.80 +5C0N_A 67 G 0.48 0.38 -1.73 0.80 0.96 1.07 75.07 5.52 -0.40 +5C0N_A 68 V 0.49 0.32 1.01 0.92 0.96 1.04 117.15 5.49 4.20 +5C0N_A 69 E 0.52 0.67 1.31 0.88 0.97 1.02 147.13 4.00 -3.50 +5C0N_A 70 F 0.53 0.47 1.49 0.87 0.98 1.01 165.19 5.52 2.80 +5C0N_A 71 D 0.53 0.92 1.41 0.78 1.00 1.01 133.10 3.80 -3.50 +5C0N_A 72 E 0.54 0.53 2.24 0.80 1.01 0.97 147.13 4.00 -3.50 +5C0N_A 73 I 0.55 1.03 2.56 0.91 1.01 0.97 131.17 5.52 4.50 +5C0N_A 74 T 0.56 1.03 5.30 1.03 1.01 0.94 119.12 5.19 -0.70 +5C0N_A 75 A 0.56 1.17 4.47 0.96 1.02 0.94 89.09 5.57 1.80 +5C0N_A 76 D 0.55 3.33 4.17 1.00 1.04 0.95 133.10 3.80 -3.50 +5C0N_A 77 D 0.53 1.71 4.79 1.00 1.04 0.98 133.10 3.80 -3.50 +5C0N_A 78 R 0.51 3.39 4.86 1.01 1.05 0.99 174.20 9.75 -4.50 +5C0N_A 79 K 0.49 2.72 5.49 1.12 1.05 0.98 146.19 8.75 -3.90 +5C0N_A 80 V 0.46 1.14 2.91 0.98 1.03 1.02 117.15 5.49 4.20 +5C0N_A 81 K 0.44 0.41 0.34 0.83 1.02 1.06 146.19 8.75 -3.90 +5C0N_A 82 S 0.43 0.29 0.49 0.84 0.99 1.07 105.09 5.24 -0.80 +5C0N_A 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0.92 75.07 5.52 -0.40 +5C0N_A 100 K 0.54 1.93 4.04 1.19 1.10 0.91 146.19 8.75 -3.90 +5C0N_A 101 S 0.54 0.81 4.33 1.12 1.10 0.95 105.09 5.24 -0.80 +5C0N_A 102 T 0.54 1.63 3.71 1.06 1.09 0.96 119.12 5.19 -0.70 +5C0N_A 103 T 0.53 1.60 3.50 0.97 1.07 0.96 119.12 5.19 -0.70 +5C0N_A 104 I 0.52 2.39 3.50 0.97 1.06 0.96 131.17 5.52 4.50 +5C0N_A 105 K 0.51 3.24 3.17 0.90 1.05 0.94 146.19 8.75 -3.90 +5C0N_A 106 R 0.51 3.75 3.86 0.97 1.05 0.93 174.20 9.75 -4.50 +5C0N_A 107 K 0.51 5.29 3.93 1.06 1.06 0.93 146.19 8.75 -3.90 +5C0N_A 108 R 0.51 4.42 6.50 1.20 1.06 0.89 174.20 9.75 -4.50 +5C0N_A 109 D 0.50 4.51 6.50 1.20 1.07 0.89 133.10 3.80 -3.50 +5C0N_A 110 G 0.49 1.86 4.59 1.15 1.07 0.94 75.07 5.52 -0.40 +5C0N_A 111 D 0.47 0.71 3.24 1.08 1.05 1.01 133.10 3.80 -3.50 +5C0N_A 112 K 0.45 0.31 2.11 1.01 1.02 1.08 146.19 8.75 -3.90 +5C0N_A 113 L 0.43 0.55 1.80 0.91 0.99 1.08 131.17 5.52 3.80 +5C0N_A 114 V 0.43 0.18 1.19 0.86 0.95 1.15 117.15 5.49 4.20 +5C0N_A 115 V 0.42 0.07 -0.77 0.72 0.93 1.23 117.15 5.49 4.20 +5C0N_A 116 E 0.42 0.08 -2.19 0.66 0.91 1.21 147.13 4.00 -3.50 +5C0N_A 117 C 0.40 0.21 -0.06 0.72 0.91 1.17 121.15 5.52 2.50 +5C0N_A 118 V 0.40 0.28 1.29 0.87 0.93 1.09 117.15 5.49 4.20 +5C0N_A 119 M 0.40 0.12 1.29 0.87 0.95 1.09 149.21 5.28 1.90 +5C0N_A 120 K 0.42 0.33 0.91 0.90 0.98 1.10 146.19 8.75 -3.90 +5C0N_A 121 G 0.42 0.59 1.64 0.94 1.02 1.05 75.07 5.52 -0.40 +5C0N_A 122 V 0.45 0.86 2.91 1.00 1.04 0.98 117.15 5.49 4.20 +5C0N_A 123 T 0.44 0.84 4.11 1.05 1.06 0.98 119.12 5.19 -0.70 +5C0N_A 124 S 0.44 0.63 2.77 0.98 1.06 1.05 105.09 5.24 -0.80 +5C0N_A 125 T 0.44 1.33 1.69 0.92 1.05 1.09 119.12 5.19 -0.70 +5C0N_A 126 R 0.45 1.59 3.33 0.95 1.02 1.01 174.20 9.75 -4.50 +5C0N_A 127 V 0.46 2.33 3.19 0.95 1.00 1.01 117.15 5.49 4.20 +5C0N_A 128 Y 0.41 1.63 2.56 0.84 0.00 1.02 181.19 5.52 -1.30 +5C0N_A 129 E 0.36 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +5C0N_A 130 R 0.31 0.00 0.00 0.00 0.00 0.00 174.20 9.75 -4.50 +5C0N_A 131 A 0.26 0.00 0.00 0.00 0.00 0.00 89.09 5.57 1.80 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0.97 1.05 105.09 5.24 -0.80 +4Z5R_A 18 L 0.60 0.10 -0.90 0.96 0.95 1.12 131.17 5.52 3.80 +4Z5R_A 19 F 0.59 0.12 -3.03 0.90 0.93 1.17 165.19 5.52 2.80 +4Z5R_A 20 S 0.58 0.18 -1.07 0.98 0.93 1.14 105.09 5.24 -0.80 +4Z5R_A 21 C 0.58 0.36 -0.57 0.98 0.95 1.12 121.15 5.52 2.50 +4Z5R_A 22 L 0.58 0.82 1.34 1.03 0.97 1.06 131.17 5.52 3.80 +4Z5R_A 23 K 0.58 0.83 2.96 1.08 1.00 1.06 146.19 8.75 -3.90 +4Z5R_A 24 D 0.57 2.59 3.46 1.09 1.01 1.04 133.10 3.80 -3.50 +4Z5R_A 25 R 0.58 2.72 1.94 1.00 1.00 1.00 174.20 9.75 -4.50 +4Z5R_A 26 H 0.58 1.35 4.07 1.14 0.98 0.94 155.16 6.74 -3.20 +4Z5R_A 27 D 0.57 0.70 1.94 1.08 0.96 0.97 133.10 3.80 -3.50 +4Z5R_A 28 F 0.56 0.55 0.81 1.09 0.95 0.99 165.19 5.52 2.80 +4Z5R_A 29 G 0.56 0.70 1.07 1.10 0.97 1.02 75.07 5.52 -0.40 +4Z5R_A 30 F 0.55 0.73 1.89 1.07 1.00 0.98 165.19 5.52 2.80 +4Z5R_A 31 P 0.54 1.46 1.57 0.96 1.04 0.98 115.13 5.96 -1.60 +4Z5R_A 32 Q 0.55 1.27 1.57 0.96 1.06 0.98 146.15 5.52 -3.50 +4Z5R_A 33 E 0.56 1.46 1.57 0.96 1.06 0.98 147.13 4.00 -3.50 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89.09 5.57 1.80 +4Z5R_A 67 A 0.63 0.88 3.57 1.05 0.98 0.97 89.09 5.57 1.80 +4Z5R_A 68 W 0.60 0.95 3.39 0.98 0.99 0.95 204.23 5.52 -0.90 +4Z5R_A 69 D 0.56 0.77 1.14 0.86 1.01 0.99 133.10 3.80 -3.50 +4Z5R_A 70 E 0.54 0.63 -0.47 0.85 1.03 1.01 147.13 4.00 -3.50 +4Z5R_A 71 T 0.53 1.00 0.66 0.97 1.03 0.98 119.12 5.19 -0.70 +4Z5R_A 72 L 0.49 1.20 2.90 0.97 1.03 0.99 131.17 5.52 3.80 +4Z5R_A 73 L 0.48 0.60 0.16 0.85 1.02 1.02 131.17 5.52 3.80 +4Z5R_A 74 D 0.47 0.65 -1.23 0.91 1.01 1.07 133.10 3.80 -3.50 +4Z5R_A 75 K 0.45 1.14 -1.23 0.91 1.01 1.07 146.19 8.75 -3.90 +4Z5R_A 76 F 0.42 2.40 1.20 0.93 1.00 1.01 165.19 5.52 2.80 +4Z5R_A 77 Y 0.43 1.18 1.20 0.93 0.99 1.01 181.19 5.52 -1.30 +4Z5R_A 78 T 0.44 0.93 -0.50 0.88 0.99 1.05 119.12 5.19 -0.70 +4Z5R_A 79 E 0.45 1.85 -0.46 0.88 0.99 1.06 147.13 4.00 -3.50 +4Z5R_A 80 L 0.43 2.05 1.71 0.93 0.99 1.05 131.17 5.52 3.80 +4Z5R_A 81 Y 0.46 1.17 0.67 0.85 0.99 1.06 181.19 5.52 -1.30 +4Z5R_A 82 Q 0.46 1.09 0.93 0.94 0.99 1.05 146.15 5.52 -3.50 +4Z5R_A 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1.02 105.09 5.24 -0.80 +4Z5R_A 100 I 0.52 0.21 0.79 0.84 0.96 1.08 131.17 5.52 4.50 +4Z5R_A 101 L 0.52 0.24 0.27 0.87 0.94 1.09 131.17 5.52 3.80 +4Z5R_A 102 A 0.52 0.36 -0.34 0.80 0.94 1.09 89.09 5.57 1.80 +4Z5R_A 103 V 0.50 0.80 -1.54 0.76 0.96 1.12 117.15 5.49 4.20 +4Z5R_A 104 R 0.50 0.84 -1.71 0.78 0.98 1.11 174.20 9.75 -4.50 +4Z5R_A 105 K 0.51 1.45 0.46 0.83 0.99 1.07 146.19 8.75 -3.90 +4Z5R_A 106 Y 0.48 3.82 0.76 0.88 0.99 1.05 181.19 5.52 -1.30 +4Z5R_A 107 F 0.48 1.37 0.14 0.87 0.99 1.01 165.19 5.52 2.80 +4Z5R_A 108 Q 0.51 0.99 0.29 0.87 0.99 1.02 146.15 5.52 -3.50 +4Z5R_A 109 R 0.50 0.52 -1.84 0.81 0.99 1.06 174.20 9.75 -4.50 +4Z5R_A 110 I 0.47 0.94 -1.84 0.81 0.98 1.06 131.17 5.52 4.50 +4Z5R_A 111 T 0.46 0.45 -1.84 0.81 0.96 1.09 119.12 5.19 -0.70 +4Z5R_A 112 L 0.48 0.46 -1.89 0.82 0.95 1.08 131.17 5.52 3.80 +4Z5R_A 113 Y 0.49 1.13 -1.37 0.79 0.95 1.07 181.19 5.52 -1.30 +4Z5R_A 114 L 0.48 1.56 0.59 0.86 0.98 1.04 131.17 5.52 3.80 +4Z5R_A 115 K 0.50 3.79 0.66 0.87 1.02 1.04 146.19 8.75 -3.90 +4Z5R_A 116 E 0.49 3.79 1.70 0.95 1.05 1.03 147.13 4.00 -3.50 +4Z5R_A 117 K 0.48 6.16 2.90 0.99 1.06 1.01 146.19 8.75 -3.90 +4Z5R_A 118 K 0.48 4.76 4.51 1.12 1.06 0.98 146.19 8.75 -3.90 +4Z5R_A 119 Y 0.48 1.47 3.90 1.15 1.04 1.05 181.19 5.52 -1.30 +4Z5R_A 120 S 0.48 0.74 3.09 1.14 1.01 1.08 105.09 5.24 -0.80 +4Z5R_A 121 P 0.46 0.39 0.84 1.13 0.99 1.08 115.13 5.96 -1.60 +4Z5R_A 122 C 0.44 0.43 1.14 1.09 0.95 1.07 121.15 5.52 2.50 +4Z5R_A 123 A 0.41 0.24 0.89 1.00 0.94 1.10 89.09 5.57 1.80 +4Z5R_A 124 W 0.40 0.11 -0.57 0.87 0.92 1.15 204.23 5.52 -0.90 +4Z5R_A 125 E 0.39 0.42 -0.27 0.79 0.92 1.12 147.13 4.00 -3.50 +4Z5R_A 126 V 0.38 0.42 -0.17 0.71 0.93 1.07 117.15 5.49 4.20 +4Z5R_A 127 V 0.36 0.69 0.64 0.72 0.94 1.04 117.15 5.49 4.20 +4Z5R_A 128 R 0.38 0.28 0.93 0.65 0.94 1.08 174.20 9.75 -4.50 +4Z5R_A 129 A 0.39 0.37 -0.79 0.63 0.94 1.08 89.09 5.57 1.80 +4Z5R_A 130 E 0.38 0.99 0.34 0.70 0.94 1.00 147.13 4.00 -3.50 +4Z5R_A 131 I 0.36 0.67 1.80 0.83 0.94 0.95 131.17 5.52 4.50 +4Z5R_A 132 M 0.39 0.58 -0.11 0.78 0.95 0.98 149.21 5.28 1.90 +4Z5R_A 133 R 0.40 0.45 0.51 0.89 0.96 0.97 174.20 9.75 -4.50 +4Z5R_A 134 S 0.39 0.53 -1.91 0.87 0.97 1.03 105.09 5.24 -0.80 +4Z5R_A 135 F 0.41 0.71 0.16 1.00 0.97 1.01 165.19 5.52 2.80 +4Z5R_A 136 S 0.44 0.52 1.50 1.06 0.98 1.02 105.09 5.24 -0.80 +4Z5R_A 137 L 0.42 0.63 1.90 1.14 0.99 1.01 131.17 5.52 3.80 +4Z5R_A 138 S 0.42 0.60 -0.34 1.02 1.00 1.04 105.09 5.24 -0.80 +4Z5R_A 139 T 0.44 0.78 1.83 1.08 1.02 1.03 119.12 5.19 -0.70 +4Z5R_A 140 N 0.46 1.63 2.01 0.98 1.02 1.01 132.12 5.52 -3.50 +4Z5R_A 141 L 0.44 1.63 4.26 1.10 1.02 0.97 131.17 5.52 3.80 +4Z5R_A 142 Q 0.39 0.93 2.01 0.98 0.00 1.01 146.15 5.52 -3.50 +4Z5R_A 143 E 0.36 0.00 0.00 0.00 0.00 0.00 147.13 4.00 -3.50 +4Z5R_A 144 S 0.30 0.00 0.00 0.00 0.00 0.00 105.09 5.24 -0.80 +4Z5R_A 145 L 0.24 0.00 0.00 0.00 0.00 0.00 131.17 5.52 3.80 diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder-topology.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder-topology.tsv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,19 @@ +N Id Method Threshold Avg Score Cover Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length kDa I.P Avg Hydropathy Avg Cover +1 4WFF_A BepiPred-2.0 0.60 0.64 - FLKWHVPPELVRVLSA 149 165 N 0 - 16 1.89 8.75 0.54 0.58 + Emini 0.80 0.78 0.38 ...EEEE.EE...... + Parker 0.80 -1.78 0.06 .....E.......... + Chou Fosman 0.80 0.83 0.44 ...EEEEEEE...... + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEEE + All matches - - 0.06 .....E.......... + N-Glyc - - - ................ + Hydropathy - 0.54 - ++---+---++-++-+ +2 4WFF_B BepiPred-2.0 0.60 0.64 - AIFLKWHVPPELVRVLSAML 149 169 N 0 - 20 2.32 8.80 1.03 0.54 + Emini 0.80 0.67 0.30 .....EEEE.EE........ + Parker 0.80 -2.18 0.05 .......E............ + Chou Fosman 0.80 0.80 0.35 .....EEEEEEE........ + Karplus Schulz 0.80 0.95 1.00 EEEEEEEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEEEEEEE + All matches - - 0.05 .......E............ + N-Glyc - - - .................... + Hydropathy - 1.03 - ++++---+---++-++-+++ diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder.log --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder.log Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,14 @@ +makeblastdb -dbtype prot -in /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta -out ./online-test_proteom Success: + + +Building a new DB, current time: 03/20/2021 00:12:41 +New DB name: /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/online-test_proteom +New DB title: /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta +Sequence type: Protein +Keep Linkouts: T +Keep MBits: T +Maximum file size: 1000000000B +Adding sequences from FASTA; added 6 sequences in 0.00433183 seconds. +Error: +blastp -query ./online-epifinder-epitopes-fasta.fasta -db ./online-test_proteom -outfmt 6 qacc sacc pident qcovs qseq sseq qacc -task blastp-short -word_size 4 -out ./online-test_proteom_blast.csv Success: +Error: diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder.txt --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-epifinder.txt Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,70 @@ + +---- Running Parameters ---- +BepiPred-2.0 Threshold : 0.6 +Min epitope length : 10 +Max epitope length : 30 + +---- Softwares Threshold ---- +Emini : 0.8 +Parker : 0.8 +Chou Fosman : 0.8 +Karplus Schulz : 0.8 +Kolaskar : 0.8 + +---- Proteomes ---- +Alias File +test_proteom /usr/local/bioinfo/stingrayGalaxy/tools/stingray/epifinder/test-data/proteom.fasta + +---- Blast ---- +Identity : 90.0 +Cover : 90.0 +Word size : 4 +Task blastp-short: blastp-short + +---- Stats ---- +Processed proteins : 6 +NGlycosylated proteins : 0 +Identified epitopes : 2 +N-glycosylated epitopes: 0 + +---- Protein Summary ---- +Id Epitopes N-Glyc +4WFF_B 1 0 +5BVP_A 0 0 +4XAK_A 0 0 +4WFF_A 1 0 +5C0N_A 0 0 +4Z5R_A 0 0 + +---- Epitopes list ---- +N Id Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length MW(kDa) I.P Hydropathy All Matches Cover Avg Cover BepiPred2 Emini Parker Chou Fosman Karplus Schulz Kolaskar test_proteom_count test_proteom_acc test_proteom_count test_proteom_id +1 4WFF_A FLKWHVPPELVRVLSA 149 165 N 0 - 16 1.89 8.75 0.54 0.06 0.58 0.64 0.78 -1.78 0.83 0.96 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) +2 4WFF_B AIFLKWHVPPELVRVLSAML 149 169 N 0 - 20 2.32 8.80 1.03 0.05 0.54 0.64 0.67 -2.18 0.80 0.95 1.11 2 4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation,4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation 2 4WFF_B(100.00,100.00),4WFF_A(100.00,100.00) + +---- Epitopes topology ---- +N Id Method Threshold Avg Score Cover Epitope Start End N-Glyc N-Glyc-Count N-Glyc-Motifs Length kDa I.P Avg Hydropathy Avg Cover +1 4WFF_A BepiPred-2.0 0.60 0.64 - FLKWHVPPELVRVLSA 149 165 N 0 - 16 1.89 8.75 0.54 0.58 + Emini 0.80 0.78 0.38 ...EEEE.EE...... + Parker 0.80 -1.78 0.06 .....E.......... + Chou Fosman 0.80 0.83 0.44 ...EEEEEEE...... + Karplus Schulz 0.80 0.96 1.00 EEEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEEE + All matches - - 0.06 .....E.......... + N-Glyc - - - ................ + Hydropathy - 0.54 - ++---+---++-++-+ +2 4WFF_B BepiPred-2.0 0.60 0.64 - AIFLKWHVPPELVRVLSAML 149 169 N 0 - 20 2.32 8.80 1.03 0.54 + Emini 0.80 0.67 0.30 .....EEEE.EE........ + Parker 0.80 -2.18 0.05 .......E............ + Chou Fosman 0.80 0.80 0.35 .....EEEEEEE........ + Karplus Schulz 0.80 0.95 1.00 EEEEEEEEEEEEEEEEEEEE + Kolaskar 0.80 1.11 1.00 EEEEEEEEEEEEEEEEEEEE + All matches - - 0.05 .......E............ + N-Glyc - - - .................... + Hydropathy - 1.03 - ++++---+---++-++-+++ +Generated files: + ./online-epifinder-parameters.txt + ./online-epifinder-protein-summary.tsv + ./online-epifinder-topology.tsv + ./online-epifinder-epitope-detail.tsv + ./online-epifinder-scores.tsv + ./online-epifinder-epitopes-fasta.fasta \ No newline at end of file diff -r 000000000000 -r ef26009cd70a test-data/online-epifinder.xls Binary file test-data/online-epifinder.xls has changed diff -r 000000000000 -r ef26009cd70a test-data/online-test_proteom.phr Binary file test-data/online-test_proteom.phr has changed diff -r 000000000000 -r ef26009cd70a test-data/online-test_proteom.pin Binary file test-data/online-test_proteom.pin has changed diff -r 000000000000 -r ef26009cd70a test-data/online-test_proteom.psq Binary file test-data/online-test_proteom.psq has changed diff -r 000000000000 -r ef26009cd70a test-data/online-test_proteom_blast.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/online-test_proteom_blast.csv Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,5 @@ +qacc sacc pident qcovs qseq sseq qacc +1-FLKWHVPPELVRVLSA 4WFF_B 100.00 100 FLKWHVPPELVRVLSA FLKWHVPPELVRVLSA +1-FLKWHVPPELVRVLSA 4WFF_A 100.00 100 FLKWHVPPELVRVLSA FLKWHVPPELVRVLSA +2-AIFLKWHVPPELVRVLSAML 4WFF_B 100.00 100 AIFLKWHVPPELVRVLSAML AIFLKWHVPPELVRVLSAML +2-AIFLKWHVPPELVRVLSAML 4WFF_A 100.00 100 AIFLKWHVPPELVRVLSAML AIFLKWHVPPELVRVLSAML diff -r 000000000000 -r ef26009cd70a test-data/proteom.fasta --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/proteom.fasta Thu Nov 25 01:26:36 2021 +0000 @@ -0,0 +1,12 @@ +>5C0N_A Chain A of Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. +CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA +>5BVP_A Chain A of The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta +VRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGGGQDITDFTMQFVSS +>4XAK_A Chain A of Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD +VECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQYGTTNSVCPKLEFA +>4WFF_A Chain A of Human TRAAK K+ channel in a K+ bound nonconductive conformation +RSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVV +>4WFF_B Chain B of Human TRAAK K+ channel in a K+ bound nonconductive conformation +RSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETQSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLR +>4Z5R_A Chain A of Rontalizumab Fab bound to Interferon-a2 +LGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESL