| 46 | 1 <html> | 
|  | 2 | 
|  | 3 <head> | 
|  | 4 <meta http-equiv=Content-Type content="text/html; charset=windows-1252"> | 
|  | 5 <meta name=Generator content="Microsoft Word 14 (filtered)"> | 
|  | 6 <style> | 
|  | 7 <!-- | 
|  | 8  /* Font Definitions */ | 
|  | 9  @font-face | 
|  | 10 	{font-family:Calibri; | 
|  | 11 	panose-1:2 15 5 2 2 2 4 3 2 4;} | 
|  | 12  /* Style Definitions */ | 
|  | 13  p.MsoNormal, li.MsoNormal, div.MsoNormal | 
|  | 14 	{margin-top:0in; | 
|  | 15 	margin-right:0in; | 
|  | 16 	margin-bottom:10.0pt; | 
|  | 17 	margin-left:0in; | 
|  | 18 	line-height:115%; | 
|  | 19 	font-size:11.0pt; | 
|  | 20 	font-family:"Calibri","sans-serif";} | 
|  | 21 p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing | 
|  | 22 	{margin:0in; | 
|  | 23 	margin-bottom:.0001pt; | 
|  | 24 	font-size:11.0pt; | 
|  | 25 	font-family:"Calibri","sans-serif";} | 
|  | 26 .MsoChpDefault | 
|  | 27 	{font-family:"Calibri","sans-serif";} | 
|  | 28 .MsoPapDefault | 
|  | 29 	{margin-bottom:10.0pt; | 
|  | 30 	line-height:115%;} | 
|  | 31 @page WordSection1 | 
|  | 32 	{size:8.5in 11.0in; | 
|  | 33 	margin:1.0in 1.0in 1.0in 1.0in;} | 
|  | 34 div.WordSection1 | 
|  | 35 	{page:WordSection1;} | 
|  | 36 --> | 
|  | 37 </style> | 
|  | 38 | 
|  | 39 </head> | 
|  | 40 | 
|  | 41 <body lang=EN-US> | 
|  | 42 | 
|  | 43 <div class=WordSection1> | 
|  | 44 | 
|  | 45 <p class=MsoNoSpacingCxSpFirst style='text-align:justify'><span | 
|  | 46 style='font-size:12.0pt;font-family:"Times New Roman","serif"'>For each donor a | 
|  | 47 subtab is provided containing information on the sequence overlap between | 
|  | 48 replicates of the different replicates of one donor. Dependent on the settings | 
|  | 49 of the Shared clonal types / clonality filter a clonality score is given.  The clonality | 
|  | 50 score  is calculated according to the formula described by </span><a | 
|  | 51 name="OLE_LINK13"></a><a name="OLE_LINK12"></a><a name="OLE_LINK11"><span | 
|  | 52 lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Boyd | 
|  | 53 et al, PMID: 20161664. </span></a></p> | 
|  | 54 | 
|  | 55 <p class=MsoNoSpacingCxSpLast style='text-align:justify'><span lang=EN-GB | 
|  | 56 style='font-size:12.0pt;font-family:"Times New Roman","serif"'>For each | 
|  | 57 individual replicate the number of reads is reported. In addition, the number | 
|  | 58 of coincidences between the different replicates of the same donor are reported. | 
|  | 59 </span></p> | 
|  | 60 | 
|  | 61 <p class=MsoNormal> </p> | 
|  | 62 | 
|  | 63 </div> | 
|  | 64 | 
|  | 65 </body> | 
|  | 66 | 
|  | 67 </html> |