annotate shm_frequency.htm @ 70:21d757c39525 draft

Uploaded
author davidvanzessen
date Tue, 29 Jan 2019 08:40:17 -0500
parents ba33b94637ca
children 6809c63d9161
Ignore whitespace changes - Everywhere: Within whitespace: At end of lines:
rev   line source
67
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
1 <html>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
2
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
3 <head>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
4 <meta http-equiv=Content-Type content="text/html; charset=windows-1252">
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
5 <meta name=Generator content="Microsoft Word 14 (filtered)">
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
6 <style>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
7 <!--
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
8 /* Style Definitions */
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
9 p.MsoNormal, li.MsoNormal, div.MsoNormal
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
10 {margin-top:0in;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
11 margin-right:0in;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
12 margin-bottom:10.0pt;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
13 margin-left:0in;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
14 line-height:115%;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
15 font-size:11.0pt;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
16 font-family:"Calibri","sans-serif";}
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
17 .MsoChpDefault
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
18 {font-family:"Calibri","sans-serif";}
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
19 .MsoPapDefault
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
20 {margin-bottom:10.0pt;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
21 line-height:115%;}
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
22 @page WordSection1
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
23 {size:8.5in 11.0in;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
24 margin:1.0in 1.0in 1.0in 1.0in;}
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
25 div.WordSection1
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
26 {page:WordSection1;}
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
27 -->
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
28 </style>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
29
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
30 </head>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
31
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
32 <body lang=EN-US>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
33
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
34 <div class=WordSection1>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
35
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
36 <p class=MsoNormalCxSpFirst style='text-align:justify'><b><u><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
37 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>SHM
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
38 frequency tab</span></u></b></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
39
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
40 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
41 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs</span></b></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
42
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
43 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
44 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
45 graphs give insight into the level of SHM. The data represented in these graphs
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
46 can be downloaded in the download tab. <a name="OLE_LINK24"></a><a
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
47 name="OLE_LINK23"></a><a name="OLE_LINK90"></a><a name="OLE_LINK89">More
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
48 information on the values found in healthy individuals of different ages can be
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
49 found in IJspeert and van Schouwenburg et al, PMID: 27799928. </a></span></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
50
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
51 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
52 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Frequency
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
53 scatter plot</span></u></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
54
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
55 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
56 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
57 dot plot showing the percentage of SHM in each transcript divided into the
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
58 different (sub)classes. </span><span lang=NL style='font-size:12.0pt;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
59 line-height:115%;font-family:"Times New Roman","serif"'>In the graph each dot
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
60 represents an individual transcript.</span></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
61
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
62 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
63 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Mutation
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
64 frequency by class</span></u></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
65
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
66 <p class=MsoNormalCxSpLast style='text-align:justify'><span lang=EN-GB
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
67 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
68 bar graph showing the percentage of transcripts that contain 0%, 0-2%, 2-5%,
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
69 5-10% 10-15%, 15-20% or more than 20% SHM for each subclass. </span></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
70
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
71 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
72 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
73 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
74 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
75 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
76 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
77 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
78 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
79 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
80 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
81 style='color:windowtext'>Link</span></a>]</span></p>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
82
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
83 </div>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
84
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
85 </body>
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
86
ba33b94637ca Uploaded
davidvanzessen
parents: 39
diff changeset
87 </html>