Mercurial > repos > davidvanzessen > shm_csr
annotate shm_transition.htm @ 95:d63eff357515 draft
planemo upload commit d96a736dcd6da34137f79861fbc6369716c332f1
| author | rhpvorderman |
|---|---|
| date | Mon, 27 Mar 2023 13:11:53 +0000 |
| parents | 6809c63d9161 |
| children |
| rev | line source |
|---|---|
| 67 | 1 <html> |
| 2 | |
| 3 <head> | |
|
90
6809c63d9161
"planemo upload commit fd64827ff6e63df008f6f50ddb8576ad2b1dbb26"
rhpvorderman
parents:
67
diff
changeset
|
4 <meta http-equiv=Content-Type content="text/html; charset=UTF-8"> |
| 67 | 5 <meta name=Generator content="Microsoft Word 14 (filtered)"> |
| 6 <style> | |
| 7 <!-- | |
| 8 /* Font Definitions */ | |
| 9 @font-face | |
| 10 {font-family:Calibri; | |
| 11 panose-1:2 15 5 2 2 2 4 3 2 4;} | |
| 12 /* Style Definitions */ | |
| 13 p.MsoNormal, li.MsoNormal, div.MsoNormal | |
| 14 {margin-top:0in; | |
| 15 margin-right:0in; | |
| 16 margin-bottom:10.0pt; | |
| 17 margin-left:0in; | |
| 18 line-height:115%; | |
| 19 font-size:11.0pt; | |
| 20 font-family:"Calibri","sans-serif";} | |
| 21 a:link, span.MsoHyperlink | |
| 22 {color:blue; | |
| 23 text-decoration:underline;} | |
| 24 a:visited, span.MsoHyperlinkFollowed | |
| 25 {color:purple; | |
| 26 text-decoration:underline;} | |
| 27 p.msochpdefault, li.msochpdefault, div.msochpdefault | |
| 28 {mso-style-name:msochpdefault; | |
| 29 margin-right:0in; | |
| 30 margin-left:0in; | |
| 31 font-size:12.0pt; | |
| 32 font-family:"Calibri","sans-serif";} | |
| 33 p.msopapdefault, li.msopapdefault, div.msopapdefault | |
| 34 {mso-style-name:msopapdefault; | |
| 35 margin-right:0in; | |
| 36 margin-bottom:10.0pt; | |
| 37 margin-left:0in; | |
| 38 line-height:115%; | |
| 39 font-size:12.0pt; | |
| 40 font-family:"Times New Roman","serif";} | |
| 41 span.apple-converted-space | |
| 42 {mso-style-name:apple-converted-space;} | |
| 43 .MsoChpDefault | |
| 44 {font-size:10.0pt; | |
| 45 font-family:"Calibri","sans-serif";} | |
| 46 .MsoPapDefault | |
| 47 {margin-bottom:10.0pt; | |
| 48 line-height:115%;} | |
| 49 @page WordSection1 | |
| 50 {size:8.5in 11.0in; | |
| 51 margin:1.0in 1.0in 1.0in 1.0in;} | |
| 52 div.WordSection1 | |
| 53 {page:WordSection1;} | |
| 54 --> | |
| 55 </style> | |
| 56 | |
| 57 </head> | |
| 58 | |
| 59 <body lang=EN-US link=blue vlink=purple> | |
| 60 | |
| 61 <div class=WordSection1> | |
| 62 | |
| 63 <p class=MsoNormalCxSpFirst style='text-align:justify'><span style='font-size: | |
| 64 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs and | |
| 65 tables give insight into the targeting and patterns of SHM. This can give | |
| 66 insight into the DNA repair pathways used to solve the U:G mismatches | |
| 67 introduced by AID. More information on the values found in healthy individuals | |
| 68 of different ages can be found in IJspeert and van Schouwenburg et al, PMID: | |
| 69 27799928.</span></p> | |
| 70 | |
| 71 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span | |
| 72 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs | |
| 73 </span></b></p> | |
| 74 | |
| 75 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK93"></a><a | |
| 76 name="OLE_LINK92"></a><a name="OLE_LINK91"><u><span style='font-size:12.0pt; | |
| 77 line-height:115%;font-family:"Times New Roman","serif"'>Heatmap transition | |
| 78 information</span></u></a></p> | |
| 79 | |
| 80 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK98"></a><a | |
| 81 name="OLE_LINK97"><span style='font-size:12.0pt;line-height:115%;font-family: | |
| 82 "Times New Roman","serif"'>Heatmaps visualizing for each subclass the frequency | |
| 83 of all possible substitutions. On the x-axes the original base is shown, while | |
| 84 the y-axes shows the new base. The darker the shade of blue, the more frequent | |
|
90
6809c63d9161
"planemo upload commit fd64827ff6e63df008f6f50ddb8576ad2b1dbb26"
rhpvorderman
parents:
67
diff
changeset
|
85 this type of substitution is occurring. </span></a></p> |
| 67 | 86 |
| 87 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span | |
| 88 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bargraph | |
| 89 transition information</span></u></p> | |
| 90 | |
| 91 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size: | |
| 92 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bar graph | |
| 93 visualizing for each original base the distribution of substitutions into the other | |
| 94 bases. A graph is included for each (sub)class. </span></p> | |
| 95 | |
| 96 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span | |
| 97 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Tables</span></b></p> | |
| 98 | |
| 99 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size: | |
| 100 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transition | |
| 101 tables are shown for each (sub)class. All the original bases are listed | |
| 102 horizontally, while the new bases are listed vertically. </span></p> | |
| 103 | |
| 104 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%; | |
| 105 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van | |
| 106 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen, | |
| 107 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span | |
| 108 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation | |
| 109 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and | |
| 110 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a | |
| 111 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span | |
| 112 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a | |
| 113 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span | |
| 114 style='color:windowtext'>Link</span></a>]</span></p> | |
| 115 | |
| 116 </div> | |
| 117 | |
| 118 </body> | |
| 119 | |
| 120 </html> |