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4 <meta http-equiv=Content-Type content="text/html; charset=windows-1252">
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5 <meta name=Generator content="Microsoft Word 14 (filtered)">
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30 </head>
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31
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32 <body lang=EN-US>
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33
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34 <div class=WordSection1>
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35
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36 <p class=MsoNormalCxSpFirst style='text-align:justify'><b><u><span lang=EN-GB
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37 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>SHM
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38 frequency tab</span></u></b></p>
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39
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40 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span lang=EN-GB
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41 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs</span></b></p>
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42
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43 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
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44 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
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45 graphs give insight into the level of SHM. The data represented in these graphs
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46 can be downloaded in the download tab. <a name="OLE_LINK24"></a><a
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47 name="OLE_LINK23"></a><a name="OLE_LINK90"></a><a name="OLE_LINK89">More
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48 information on the values found in healthy individuals of different ages can be
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49 found in IJspeert and van Schouwenburg et al, PMID: 27799928. </a></span></p>
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50
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51 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
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52 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Frequency
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53 scatter plot</span></u></p>
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54
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55 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
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56 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
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57 dot plot showing the percentage of SHM in each transcript divided into the
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58 different (sub)classes. </span><span lang=NL style='font-size:12.0pt;
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59 line-height:115%;font-family:"Times New Roman","serif"'>In the graph each dot
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60 represents an individual transcript.</span></p>
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61
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62 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
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63 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Mutation
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64 frequency by class</span></u></p>
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65
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66 <p class=MsoNormalCxSpLast style='text-align:justify'><span lang=EN-GB
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67 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
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68 bar graph showing the percentage of transcripts that contain 0%, 0-2%, 2-5%,
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69 5-10% 10-15%, 15-20% or more than 20% SHM for each subclass. </span></p>
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70
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71 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
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72 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
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73 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
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74 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
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75 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
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76 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
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77 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
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78 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
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79 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
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80 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
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81 style='color:windowtext'>Link</span></a>]</span></p>
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82
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83 </div>
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84
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85 </body>
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86
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87 </html>
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