comparison shm_frequency.htm @ 39:a24f8c93583a draft

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36 <p class=MsoNormalCxSpFirst style='text-align:justify'><b><u><span lang=EN-GB
37 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>SHM
38 frequency tab</span></u></b></p>
39
40 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span lang=EN-GB
41 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs</span></b></p>
42
43 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
44 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
45 graphs give insight into the level of SHM. The data represented in these graphs
46 can be downloaded in the download tab. <a name="OLE_LINK24"></a><a
47 name="OLE_LINK23"></a><a name="OLE_LINK90"></a><a name="OLE_LINK89">More
48 information on the values found in healthy individuals of different ages can be
49 found in IJspeert and van Schouwenburg et al, PMID: 27799928. </a></span></p>
50
51 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
52 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Frequency
53 scatter plot</span></u></p>
54
55 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
56 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
57 dot plot showing the percentage of SHM in each transcript divided into the
58 different (sub)classes. </span><span lang=NL style='font-size:12.0pt;
59 line-height:115%;font-family:"Times New Roman","serif"'>In the graph each dot
60 represents an individual transcript.</span></p>
61
62 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
63 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Mutation
64 frequency by class</span></u></p>
65
66 <p class=MsoNormalCxSpLast style='text-align:justify'><span lang=EN-GB
67 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
68 bar graph showing the percentage of transcripts that contain 0%, 0-2%, 2-5%,
69 5-10% 10-15%, 15-20% or more than 20% SHM for each subclass. </span></p>
70
71 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
72 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
73 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
74 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
75 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
76 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
77 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
78 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
79 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
80 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
81 style='color:windowtext'>Link</span></a>]</span></p>
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