Mercurial > repos > davidvanzessen > shm_csr

<html>

<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=Generator content="Microsoft Word 14 (filtered)">
<style>
<!--
 /* Font Definitions */
 @font-face
	{font-family:Calibri;
	panose-1:2 15 5 2 2 2 4 3 2 4;}
 /* Style Definitions */
 p.MsoNormal, li.MsoNormal, div.MsoNormal
	{margin-top:0in;
	margin-right:0in;
	margin-bottom:10.0pt;
	margin-left:0in;
	line-height:115%;
	font-size:11.0pt;
	font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
	{color:blue;
	text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
	{color:purple;
	text-decoration:underline;}
p.msochpdefault, li.msochpdefault, div.msochpdefault
	{mso-style-name:msochpdefault;
	margin-right:0in;
	margin-left:0in;
	font-size:12.0pt;
	font-family:"Calibri","sans-serif";}
p.msopapdefault, li.msopapdefault, div.msopapdefault
	{mso-style-name:msopapdefault;
	margin-right:0in;
	margin-bottom:10.0pt;
	margin-left:0in;
	line-height:115%;
	font-size:12.0pt;
	font-family:"Times New Roman","serif";}
span.apple-converted-space
	{mso-style-name:apple-converted-space;}
.MsoChpDefault
	{font-size:10.0pt;
	font-family:"Calibri","sans-serif";}
.MsoPapDefault
	{margin-bottom:10.0pt;
	line-height:115%;}
@page WordSection1
	{size:8.5in 11.0in;
	margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
	{page:WordSection1;}
-->
</style>

</head>

<body lang=EN-US link=blue vlink=purple>

<div class=WordSection1>

<p class=MsoNormalCxSpFirst style='text-align:justify'><span style='font-size:
12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs and
tables give insight into the targeting and patterns of SHM. This can give
insight into the DNA repair pathways used to solve the U:G mismatches
introduced by AID. More information on the values found in healthy individuals
of different ages can be found in IJspeert and van Schouwenburg et al, PMID:
27799928.</span></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs
</span></b></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK93"></a><a
name="OLE_LINK92"></a><a name="OLE_LINK91"><u><span style='font-size:12.0pt;
line-height:115%;font-family:"Times New Roman","serif"'>Heatmap transition
information</span></u></a></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK98"></a><a
name="OLE_LINK97"><span style='font-size:12.0pt;line-height:115%;font-family:
"Times New Roman","serif"'>Heatmaps visualizing for each subclass the frequency
of all possible substitutions. On the x-axes the original base is shown, while
the y-axes shows the new base. The darker the shade of blue, the more frequent
this type of substitution is occurring.  </span></a></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span
style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bargraph
transition information</span></u></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bar graph
visualizing for each original base the distribution of substitutions into the other
bases. A graph is included for each (sub)class. </span></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Tables</span></b></p>

<p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transition
tables are shown for each (sub)class. All the original bases are listed
horizontally, while the new bases are listed vertically. </span></p>

<p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
style='color:windowtext'>Link</span></a>]</span></p>

</div>

</body>

</html>
author	davidvanzessen
date	Thu, 25 Feb 2021 10:32:32 +0000
parents	a24f8c93583a
children	ba33b94637ca