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+Discovery of significant signatures from omics data
+===================================================
+
+A Galaxy module from the [Workflow4metabolomics](http://workflow4metabolomics.org) project
+
+Status: [![Build Status](https://travis-ci.org/workflow4metabolomics/biosigner.svg?branch=master)](https://travis-ci.org/workflow4metabolomics/biosigner).
+
+## Description
+
+**Version:** 2.2.2  
+**Date:** 2016-05-21  
+**Author:** Philippe Rinaudo and Etienne A. Thevenot (CEA, LIST, MetaboHUB, W4M Core Development Team)   
+**Email:** [etienne.thevenot(at)cea.fr](mailto:etienne.thevenot@cea.fr)  
+**Citation:** Rinaudo P., Boudah S., Junot C. and Thevenot E.A. (2015). biosigner: A new method for the discovery of restricted and stable molecular signatures from omics data. *Frontiers in Molecular Biosciences*, in review.   
+**Licence:** CeCILL
+**Reference history:** [W4M00003_diaplasma](http://galaxy.workflow4metabolomics.org/history/list_published)      
+**Funding:** Agence Nationale de la Recherche ([MetaboHUB](http://www.metabohub.fr/index.php?lang=en&Itemid=473) national infrastructure for metabolomics and fluxomics, ANR-11-INBS-0010 grant)
+
+## Installation
+
+* Configuration file: `biosigner_config.xml`.
+* Image files: 
+  + `static/images/biosigner_workflowPositionImage.png`.   
+  + `static/images/biosigner_workingExampleImage.png`.
+* Wrapper file: `biosigner_wrapper.R`.
+* R packages  
+  + **batch** from CRAN: `install.packages("batch", dep=TRUE)`.
+  + **biosigner** from Bioconductor (which itself depends on **ropls** from Bioconductor and **e1071** and **randomForest** from CRAN): `source("http://www.bioconductor.org/biocLite.R") ; biocLite("biosigner")`.
+
+## Tests
+
+The code in the wrapper can be tested by running the `tests/biosigner_tests.R` in R  
+
+## News
+
+## CHANGES IN VERSION 2.2.2
+
+ * Internal updates to biosigner package versions of 1.0.0 and above, and ropls versions of 1.4.0 and above (i.e. using S4 methods instead of S3)
+    
+## CHANGES IN VERSION 2.2.1
+
+ * Creation of the tool: with S3 versions of biosigner (< 1.0.0) and ropls (< 1.4.0)