# ----------------------------------------------------------------------#
# Copyright (c) 2011, Richard Lupat & Jason Li.
#
# > Source License <
# This file is part of CONTRA.
#
#    CONTRA is free software: you can redistribute it and/or modify
#    it under the terms of the GNU General Public License as published by
#    the Free Software Foundation, either version 3 of the License, or
#    (at your option) any later version.
#
#    CONTRA is distributed in the hope that it will be useful,
#    but WITHOUT ANY WARRANTY; without even the implied warranty of
#    MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
#    GNU General Public License for more details.
#
#    You should have received a copy of the GNU General Public License
#    along with CONTRA.  If not, see <http://www.gnu.org/licenses/>.
#
# 
#-----------------------------------------------------------------------#
# Last Updated : 09 Apr 2011 11:00AM

def vcf_out(inF, outF):
	import math
	f = file.readlines(open(inF))
	vcf = open(outF, "w")

	#header
	vcf.write("##fileformat=VCFv4.0\n")
	vcf.write("##reference=1000GenomesPilot-NCBI36\n")
	vcf.write('##INFO=<ID=SVTYPE,Number=1,Type=String,Description="Type of structural variant"\n')
	vcf.write('##INFO=<ID=END,Number=1,Type=Integer,Description="End position of the variant described in this record"\n')
	vcf.write('##ALT=<ID=CNV,Description="Copy number variable region"\n')
	vcf.write("#CHROM \tPOS \tID \tREF \tALT \tQUAL \tFILTER \tINFO\n")

	count = 0 
	while count < len(f):
		if (count % 2 == 0):
			region = f[count].strip(">\n")
			region = region.split(":")
			chr = region[0]

			adjPVal = float(region[2])
			if adjPVal <= 0:
				adjPVal = 0
			else:
				adjPVal = -10 * math.log(adjPVal, 10)
			adjPVal = str(round(adjPVal,3))		
			region[1] = region[1].split("-")
			start = region[1][0]
			end = region[1][1]
		else:
			ref = f[count].strip("\n")
			vcf.write(chr +"\t"+ start + "\t" + "." + "\t" + ref + "\t")
			vcf.write("<CNV>" + "\t" + adjPVal + "\t" + "PASS" + "\t")
			vcf.write("SVTYPE=CNV;END="+ end + "\n")
		count += 1		

	vcf.close()