id	name	namespace	genus	species	dataset_21368137	dataset_21368138	dataset_21368139	dataset_21368140	dataset_21368141	dataset_21368142
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.158851	0.457588	0.367933	0.0406378	0.212081	0.0528417
GO:0000023	maltose metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	14.0012	10.3973	8.3927600000000009	14.0098	14.1239	9.89496
GO:0000025	maltose catabolic process	biological_process	Escherichia	Escherichia coli	0.0251304	0	0	0	0	0
GO:0000027	ribosomal large subunit assembly	biological_process	Clostridium	Clostridium thermocellum	4.99521	34.9239	31.4675	127.056	96.2502	105.199
GO:0000027	ribosomal large subunit assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	44.0266	70.1837	60.1184	57.3553	74.0795	40.3249
GO:0000027	ribosomal large subunit assembly	biological_process	Escherichia	Escherichia coli	0.0285816	0	0	0	0	0.0653892
GO:0000030	mannosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.50346	4.38419	2.69903	22.4856	20.2827	17.4859
GO:0000030	mannosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0323487	0	0.0586834	0	0	0
GO:0000034	adenine deaminase activity	molecular_function	Escherichia	Escherichia coli	0.0149956	0	0.0278306	0	0	0
GO:0000034	adenine deaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.148644	0.127232	0.24592	0.0508594	0.103349	0.308642
GO:0000036	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	molecular_function	Clostridium	Clostridium thermocellum	26.7934	119.275	48.5853	525.102	397.776	543.996
GO:0000036	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.661	17.4161	23.2322	12.7903	10.7163	13.3766
GO:0000036	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	molecular_function	Escherichia	Escherichia coli	0	0	0.0413174	0	0	0.118199
GO:0000041	transition metal ion transport	biological_process	Clostridium	Clostridium thermocellum	2.80498	29.9683	29.3116	37.9571	37.3748	29.8371
GO:0000041	transition metal ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0964385	0	0.631534	0.890674	0.653019	1.67182
GO:0000049	tRNA binding	molecular_function	Clostridium	Clostridium thermocellum	120.077	577.193	382.252	1919.14	1656.7	1821.14
GO:0000049	tRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	514.943	404.284	333.851	458.679	525.602	378.856
GO:0000049	tRNA binding	molecular_function	Escherichia	Escherichia coli	0.979988	0	0.574971	0	0	0.0577249
GO:0000049	tRNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.76975	2.89815	6.21105	6.1176	3.16754	7.03193
GO:0000050	urea cycle	biological_process	Escherichia	Escherichia coli	0.101785	0	0.0755531	0	0	0
GO:0000053	argininosuccinate metabolic process	biological_process	Escherichia	Escherichia coli	0.101785	0	0.0755531	0	0	0
GO:0000062	fatty-acyl-CoA binding	molecular_function	Escherichia	Escherichia coli	0.065864	0	0.0611642	0	0	0
GO:0000103	sulfate assimilation	biological_process	Clostridium	Clostridium thermocellum	60.4918	642.736	558.276	836.882	834.009	1015.38
GO:0000103	sulfate assimilation	biological_process	Escherichia	Escherichia coli	0.474196	0	0	0	0	0.189053
GO:0000104	succinate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.190617	0	0	0	0	0
GO:0000104	succinate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0365776	0.0702438	0.13577	0.299411	0.260999	0.0973401
GO:0000105	histidine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	50.019	106.794	75.405	312.907	305.015	318.959
GO:0000105	histidine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.6764	15.0269	9.61789	12.342	13.9724	11.9058
GO:0000105	histidine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.316439	0	0	0	0	0.217091
GO:0000105	histidine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.32484	2.6737	1.3264	3.74954	1.61237	3.18684
GO:0000107	imidazoleglycerol-phosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	9.3861	21.7098	11.9057	58.9753	64.8784	50.9841
GO:0000107	imidazoleglycerol-phosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0775299	0	0	0	0	0.146657
GO:0000107	imidazoleglycerol-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321494	0.576652	0.67876	0.328982	0.481327	0.855364
GO:0000150	recombinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.54379	110.706	78.5557	19.1856	19.9128	16.8752
GO:0000150	recombinase activity	molecular_function	Escherichia	Escherichia coli	0.373359	0	0	0	0	0.117487
GO:0000150	recombinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.222965	0.142728	0	0.152106	0.132735	0.197785
GO:0000155	phosphorelay sensor kinase activity	molecular_function	Clostridium	Clostridium thermocellum	19.9886	84.8723	77.9795	264.234	251.512	235.083
GO:0000155	phosphorelay sensor kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	47.2634	42.6513	42.495	39.1395	45.3117	29.564
GO:0000155	phosphorelay sensor kinase activity	molecular_function	Escherichia	Escherichia coli	1.52994	0	0.964103	0	0	0.159463
GO:0000155	phosphorelay sensor kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.01421	5.38767	2.94955	2.42178	1.27238	2.52586
GO:0000156	phosphorelay response regulator activity	molecular_function	Clostridium	Clostridium thermocellum	3.25315	9.02579	9.47242	86.7788	82.4587	83.4675
GO:0000156	phosphorelay response regulator activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.162035	0.103709	0	0.138328	0.0482239	0.0359285
GO:0000156	phosphorelay response regulator activity	molecular_function	Escherichia	Escherichia coli	0.524797	0	0.447726	0	0	0.379206
GO:0000160	phosphorelay signal transduction system	biological_process	Clostridium	Clostridium thermocellum	70.2649	506.303	446.434	1488.2	1460.77	1693.63
GO:0000160	phosphorelay signal transduction system	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	100.956	79.8029	110.565	74.3182	89.4686	68.112
GO:0000160	phosphorelay signal transduction system	biological_process	Escherichia	Escherichia coli	1.47681	0	1.9532	0	0	0.727399
GO:0000160	phosphorelay signal transduction system	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.51202	4.41789	3.26994	1.32585	1.20071	2.48618
GO:0000162	tryptophan biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	25.7733	153.11	351.052	477.749	265.751	313.128
GO:0000162	tryptophan biosynthetic process	biological_process	Escherichia	Escherichia coli	0.132749	0	0.403341	0	0	0
GO:0000162	tryptophan biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.81597	0.102682	0.0724408	0.759484	0.268335	2.15878
GO:0000166	nucleotide binding	molecular_function	Clostridium	Clostridium thermocellum	25.4954	114.889	85.4685	410.422	364.29	343.28
GO:0000166	nucleotide binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	372.746	157.945	210.439	117.333	140.82	118.404
GO:0000166	nucleotide binding	molecular_function	Escherichia	Escherichia coli	0.793357	0	1.54038	0	0	0.800485
GO:0000166	nucleotide binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.14811	4.82353	3.46074	5.50809	2.69665	10.2888
GO:0000175	3'-5'-exoribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	2.72492	16.2016	15.1478	61.5467	63.3508	61.82
GO:0000175	3'-5'-exoribonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.5488	53.4827	41.7801	34.7674	39.6371	35.03
GO:0000175	3'-5'-exoribonuclease activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0000175	3'-5'-exoribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.21215	1.6291	0.62991	0.347386	0.227186	0.62081
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.480005	3.09628	2.75081	11.3416	10.0213	10.6301
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.0203	9.38784	6.66771	7.82058	9.52142	8.62006
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.108493	0.346878	0.671228	0.148027	0.0645879	0.478842
GO:0000213	tRNA-intron endonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265668	0.514297	0	0.411078	0.0597915	0
GO:0000256	allantoin catabolic process	biological_process	Escherichia	Escherichia coli	0.0191516	0	0	0	0	0.0947853
GO:0000270	peptidoglycan metabolic process	biological_process	Clostridium	Clostridium thermocellum	3.4896	22.5746	12.9726	63.0136	57.2558	69.5533
GO:0000270	peptidoglycan metabolic process	biological_process	Escherichia	Escherichia coli	0.252908	0	0	0	0	0
GO:0000271	polysaccharide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	12.436	81.8708	65.7678	187.226	171.569	234.308
GO:0000271	polysaccharide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.0404176	0.0387858	0.149934	0.0619763	0.0541271	0.0537796
GO:0000271	polysaccharide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.103876	0	0.847052	0	0	0.0420406
GO:0000271	polysaccharide biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0636037	0.154116	0.113533	0.511504	0.13972300000000001	0.150796
GO:0000272	polysaccharide catabolic process	biological_process	Clostridium	Clostridium thermocellum	274.016	450.016	409.901	1307.84	1243.32	1384.78
GO:0000286	alanine dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.111701	0.321908	0.103745	0	0.124727	0.0743471
GO:0000287	magnesium ion binding	molecular_function	Clostridium	Clostridium thermocellum	122.057	815.864	703	2240.71	2045.67	2109.07
GO:0000287	magnesium ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	657.309	681.011	699.335	647.704	720.619	549.212
GO:0000287	magnesium ion binding	molecular_function	Escherichia	Escherichia coli	7.77015	0	4.42353	0	0	1.51142
GO:0000287	magnesium ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	8.10883	14.3757	15.0581	15.1495	9.07	14.5199
GO:0000302	response to reactive oxygen species	biological_process	Clostridium	Clostridium thermocellum	16.7778	159.381	159.13	520.725	417.94	348.992
GO:0000302	response to reactive oxygen species	biological_process	Escherichia	Escherichia coli	0.0479276	0	0.0636902	0	0	0
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.235748	0.227832	0	0.109621	0.235621
GO:0000398	mRNA splicing, via spliceosome	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.939701	0.259072	1.13035	1.35099
GO:0000413	protein peptidyl-prolyl isomerization	biological_process	Escherichia	Escherichia coli	0.103098	0	0	0	0	0
GO:0000453	enzyme-directed rRNA 2'-O-methylation	biological_process	Clostridium	Clostridium thermocellum	3.29626	6.52502	3.96548	21.0496	18.4026	15.9098
GO:0000453	enzyme-directed rRNA 2'-O-methylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.04605	1.09856	0.176907	1.79801	1.31821	0.824318
GO:0000453	enzyme-directed rRNA 2'-O-methylation	biological_process	Escherichia	Escherichia coli	0	0	0.126794	0	0	0
GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.0757071	0	0	0	0	0
GO:0000724	double-strand break repair via homologous recombination	biological_process	Clostridium	Clostridium thermocellum	6.01112	21.2068	21.8854	50.7726	47.1347	58.1933
GO:0000724	double-strand break repair via homologous recombination	biological_process	Escherichia	Escherichia coli	0.123465	0	0	0	0	0
GO:0000725	recombinational repair	biological_process	Escherichia	Escherichia coli	0.00811755	0	0.0450612	0	0	0
GO:0000737	DNA catabolic process, endonucleolytic	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.345944	1.33071	1.63181	0.299909	0.261737	0.177217
GO:0000738	DNA catabolic process, exonucleolytic	biological_process	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0000738	DNA catabolic process, exonucleolytic	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.254901	0.481252	0.621024	0.380786	0.114136	0.333252
GO:0000774	adenyl-nucleotide exchange factor activity	molecular_function	Clostridium	Clostridium thermocellum	1.50831	35.3845	47.4473	28.9627	41.5985	54.1577
GO:0000774	adenyl-nucleotide exchange factor activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	27.0761	20.5796	21.4075	11.4793	16.9678	21.1717
GO:0000774	adenyl-nucleotide exchange factor activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.265116	0.231505	0.431174
GO:0000902	cell morphogenesis	biological_process	Clostridium	Clostridium thermocellum	15.8469	88.3083	72.4931	241.257	235.342	248.508
GO:0000902	cell morphogenesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	154.516	156.139	179.37	181.218	209.801	168.777
GO:0000902	cell morphogenesis	biological_process	Escherichia	Escherichia coli	0.019905	0	0.174787	0	0	0
GO:0000902	cell morphogenesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0791583	0.55719	1.51819	0.78311	0.494826	1.3323
GO:0000906	6,7-dimethyl-8-ribityllumazine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	7.9335	68.0065	34.1373	218.064	158.846	137.481
GO:0000906	6,7-dimethyl-8-ribityllumazine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.629767	0.69147	0.835325	2.11789	0	1.55272
GO:0000908	taurine dioxygenase activity	molecular_function	Escherichia	Escherichia coli	0.0692422	0	0	0	0	0
GO:0000917	barrier septum assembly	biological_process	Clostridium	Clostridium thermocellum	171.595	868.735	578.205	2874.96	2706.63	3615.61
GO:0000917	barrier septum assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	381.898	556.293	504.685	403.076	480.933	724.606
GO:0000917	barrier septum assembly	biological_process	Escherichia	Escherichia coli	0.600213	0	0.0662161	0	0	0.228895
GO:0000917	barrier septum assembly	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	8.30122	13.182	9.61681	3.9548	3.80298	7.1035
GO:0000918	barrier septum site selection	biological_process	Clostridium	Clostridium thermocellum	8.2863	55.6835	39.4115	137.04	122.542	115.444
GO:0000918	barrier septum site selection	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	62.4331	78.3751	78.5854	80.8657	99.0399	63.0687
GO:0000918	barrier septum site selection	biological_process	Escherichia	Escherichia coli	0.0366505	0	0	0	0	0
GO:0000920	cell separation after cytokinesis	biological_process	Escherichia	Escherichia coli	0.189693	0	0	0	0	0
GO:0000967	rRNA 5'-end processing	biological_process	Clostridium	Clostridium thermocellum	20.5795	48.505	31.4653	157.155	119.907	115.06
GO:0000967	rRNA 5'-end processing	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	34.2826	19.954	8.7021	28.5855	23.0759	32.0424
GO:0000986	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding	molecular_function	Escherichia	Escherichia coli	0.149834	0	0.668882	0	0	0.181971
GO:0000987	core promoter proximal region sequence-specific DNA binding	molecular_function	Escherichia	Escherichia coli	0.905059	0	0.261482	0	0	0
GO:0001046	core promoter sequence-specific DNA binding	molecular_function	Escherichia	Escherichia coli	0	0	0.261482	0	0	0
GO:0001047	core promoter binding	molecular_function	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0001071	nucleic acid binding transcription factor activity	molecular_function	Escherichia	Escherichia coli	0.175378	0	0	0	0	0
GO:0001123	transcription initiation from bacterial-type RNA polymerase promoter	biological_process	Clostridium	Clostridium thermocellum	9.93467	48.7134	28.9363	146.277	129.107	131.137
GO:0001123	transcription initiation from bacterial-type RNA polymerase promoter	biological_process	Escherichia	Escherichia coli	0.181673	0	0.107579	0	0	0.0917454
GO:0001141	transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding	molecular_function	Escherichia	Escherichia coli	0.05675	0	0.096708	0	0	0.0693346
GO:0001407	glycerophosphodiester transport	biological_process	Clostridium	Clostridium thermocellum	115.851	297.81	235.253	1285.84	1089.39	861.139
GO:0001407	glycerophosphodiester transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	188.38	65.4715	118.616	36.1918	34.5571	42.4546
GO:0001407	glycerophosphodiester transport	biological_process	Escherichia	Escherichia coli	0.0416328	0	0.0978357	0	0	0
GO:0001514	selenocysteine incorporation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	26.1395	27.937	22.6729	21.6123	26.0746	24.3582
GO:0001514	selenocysteine incorporation	biological_process	Escherichia	Escherichia coli	0.126284	0	0	0	0	0
GO:0001516	prostaglandin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.143394	0	0	0	0	0
GO:0001522	pseudouridine synthesis	biological_process	Clostridium	Clostridium thermocellum	18.7966	81.1052	74.3503	155.841	154.52	229.781
GO:0001522	pseudouridine synthesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	48.0913	36.6866	25.7054	38.5516	38.6416	31.1142
GO:0001522	pseudouridine synthesis	biological_process	Escherichia	Escherichia coli	0.159289	0	0	0	0	0
GO:0001522	pseudouridine synthesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	2.16808	4.51064	4.43357	1.44687	1.7529
GO:0001671	ATPase activator activity	molecular_function	Escherichia	Escherichia coli	0.0933276	0	0	0	0	0
GO:0001680	tRNA 3'-terminal CCA addition	biological_process	Escherichia	Escherichia coli	0.0223111	0	0	0	0	0
GO:0001680	tRNA 3'-terminal CCA addition	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0001682	tRNA 5'-leader removal	biological_process	Clostridium	Clostridium thermocellum	7.86346	63.3051	50.074	182.415	160.09	200.806
GO:0001682	tRNA 5'-leader removal	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.77181	3.4195	3.27675	5.62935	1.25308	8.58045
GO:0001727	lipid kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.300724	0	0	0
GO:0001896	autolysis	biological_process	Escherichia	Escherichia coli	0.189693	0	0	0	0	0
GO:0002084	protein depalmitoylation	biological_process	Escherichia	Escherichia coli	0.17567	0	0	0	0	0
GO:0002097	tRNA wobble base modification	biological_process	Escherichia	Escherichia coli	0.0261755	0	0	0	0	0
GO:0002098	tRNA wobble uridine modification	biological_process	Clostridium	Clostridium thermocellum	0.432053	4.25612	3.46669	11.5249	12.645	9.23874
GO:0002098	tRNA wobble uridine modification	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.7799	6.93449	5.37135	3.54892	5.13235	3.22302
GO:0002098	tRNA wobble uridine modification	biological_process	Escherichia	Escherichia coli	0.0279254	0	0.1037	0	0	0
GO:0002098	tRNA wobble uridine modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.427095	0.271734	0.529909	0.484967	0.289929	0.383604
GO:0002100	tRNA wobble adenosine to inosine editing	biological_process	Clostridium	Clostridium thermocellum	4.98695	33.4582	24.2697	95.8039	74.3148	108.515
GO:0002100	tRNA wobble adenosine to inosine editing	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	2.08128	3.25926	2.86254	0.867992	1.23995	2.77157
GO:0002100	tRNA wobble adenosine to inosine editing	biological_process	Escherichia	Escherichia coli	0.068659	0	0	0	0	0
GO:0002101	tRNA wobble cytosine modification	biological_process	Escherichia	Escherichia coli	0	0	0.096708	0	0	0
GO:0002101	tRNA wobble cytosine modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0205126	0.0787851	0	0.0419559	0.0366128	0.109176
GO:0002128	tRNA nucleoside ribose methylation	biological_process	Escherichia	Escherichia coli	0.0862065	0	0	0	0	0
GO:0002128	tRNA nucleoside ribose methylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.103709	0.400725	0.331593	0	0
GO:0002143	tRNA wobble position uridine thiolation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	589.086	181.098	207.717	182.833	172.107	155.817
GO:0002143	tRNA wobble position uridine thiolation	biological_process	Escherichia	Escherichia coli	0.176107	0	0	0	0	0
GO:0002143	tRNA wobble position uridine thiolation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.51649	0.259226	0.142929	0	0.557555
GO:0002161	aminoacyl-tRNA editing activity	molecular_function	Clostridium	Clostridium thermocellum	8.00437	54.505	41.5771	136.035	128.623	122.37
GO:0002161	aminoacyl-tRNA editing activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	158.284	105.064	94.5064	104.218	120.14	92.288
GO:0002161	aminoacyl-tRNA editing activity	molecular_function	Escherichia	Escherichia coli	0.128714	0	0.0338298	0	0	0.0265826
GO:0002161	aminoacyl-tRNA editing activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.345749	0.644983	0.393372	0.488176	0.292013	0.470369
GO:0002237	response to molecule of bacterial origin	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0002935	tRNA (adenine-C2-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.7819	11.4019	8.76191	33.2804	31.5624	33.2572
GO:0002949	tRNA threonylcarbamoyladenosine modification	biological_process	Clostridium	Clostridium thermocellum	7.44234	54.0843	40.7572	105.925	115.964	114.083
GO:0002949	tRNA threonylcarbamoyladenosine modification	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	81.1817	37.9727	56.9503	29.163	30.6186	29.4938
GO:0002949	tRNA threonylcarbamoyladenosine modification	biological_process	Escherichia	Escherichia coli	0.171173	0	0	0	0	0
GO:0003333	amino acid transmembrane transport	biological_process	Escherichia	Escherichia coli	0.936119	0	1.37101	0	0	0.476772
GO:0003676	nucleic acid binding	molecular_function	Clostridium	Clostridium thermocellum	114.184	520.483	387.506	1648.95	1309.34	1509.48
GO:0003676	nucleic acid binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	309.965	429.289	376.093	304.893	314.471	286.154
GO:0003676	nucleic acid binding	molecular_function	Escherichia	Escherichia coli	0.844274	0	0.297747	0	0	0.177929
GO:0003676	nucleic acid binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.43943	2.57666	1.88761	3.12896	0.811602	1.79743
GO:0003677	DNA binding	molecular_function	Clostridium	Clostridium thermocellum	484.481	3689.01	3085.13	8844.89	8093.32	10257.2
GO:0003677	DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2840.89	4781.45	3624.97	2278.92	2771.38	2662.95
GO:0003677	DNA binding	molecular_function	Escherichia	Escherichia coli	39.8095	0	31.1121	0	0	22.1497
GO:0003677	DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	44.6392	87.6247	69.4342	114.896	62.6553	163.013
GO:0003678	DNA helicase activity	molecular_function	Clostridium	Clostridium thermocellum	2.12709	13.591	7.47642	55.5768	47.5258	39.9705
GO:0003678	DNA helicase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.3331	9.32455	7.93813	13.0321	15.1196	9.34772
GO:0003678	DNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.139335	0	0	0	0	0
GO:0003684	damaged DNA binding	molecular_function	Clostridium	Clostridium thermocellum	19.1707	131.229	98.1761	272.212	265.241	284.135
GO:0003684	damaged DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	78.5822	94.9076	138.856	49.2771	60.6959	55.5058
GO:0003684	damaged DNA binding	molecular_function	Escherichia	Escherichia coli	0.404322	0	0.260128	0	0	0.057789600000000003
GO:0003684	damaged DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.899712	1.28665	2.63782	1.85623	0.385769	1.02181
GO:0003688	DNA replication origin binding	molecular_function	Clostridium	Clostridium thermocellum	1.62361	6.62831	5.33811	16.0679	18.1539	20.2148
GO:0003688	DNA replication origin binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.1311	22.1648	29.882	8.47126	12.8847	8.72642
GO:0003688	DNA replication origin binding	molecular_function	Escherichia	Escherichia coli	0.038765	0	0	0	0	0
GO:0003689	DNA clamp loader activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.283823	0.741224	0.305686	0.199036	0	0.179513
GO:0003690	double-stranded DNA binding	molecular_function	Clostridium	Clostridium thermocellum	10.8248	63.0403	44.6454	121.369	122.721	152.282
GO:0003690	double-stranded DNA binding	molecular_function	Escherichia	Escherichia coli	0.20131	0	0.0179072	0	0	0.0256771
GO:0003690	double-stranded DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	7.15208	6.10864	6.2807	5.78837	4.03646	10.531
GO:0003697	single-stranded DNA binding	molecular_function	Clostridium	Clostridium thermocellum	39.8208	196.064	115.522	746.779	632.797	587.862
GO:0003697	single-stranded DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	207.604	188.811	196.58	120.494	161.102	121.232
GO:0003697	single-stranded DNA binding	molecular_function	Escherichia	Escherichia coli	0.499959	0	1.08585	0	0	0.269609
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular_function	Clostridium	Clostridium thermocellum	143.228	834.154	738.52	2142.51	1981.79	2353.96
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	485.053	646.725	653.545	303.569	391.592	386.371
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular_function	Escherichia	Escherichia coli	10.9995	0	7.20276	0	0	2.61932
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	5.23905	16.7021	13.4066	11.2138	8.94321	15.445
GO:0003723	RNA binding	molecular_function	Clostridium	Clostridium thermocellum	233.015	1271.13	1038.43	3440.49	3280.13	3683.11
GO:0003723	RNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1029.51	793.117	821.333	594.596	668.05	485.255
GO:0003723	RNA binding	molecular_function	Escherichia	Escherichia coli	3.6423	0	1.39131	0	0	0.920235
GO:0003723	RNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	11.5742	17.9269	11.8193	16.9188	7.91403	22.0151
GO:0003725	double-stranded RNA binding	molecular_function	Clostridium	Clostridium thermocellum	2.84265	18.2528	13.1783	40.0871	42.5015	49.0472
GO:0003725	double-stranded RNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.56638	14.5919	8.13037	9.36121	9.15373	10.0155
GO:0003725	double-stranded RNA binding	molecular_function	Escherichia	Escherichia coli	0.11491	0	0.0214706	0	0	0
GO:0003725	double-stranded RNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.172534	0.636721	0.820485	0.335896	0.448708	0.788519
GO:0003729	mRNA binding	molecular_function	Clostridium	Clostridium thermocellum	14.2671	38.5654	16.046	202.671	181.592	134.609
GO:0003729	mRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	72.3149	29.9106	22.1704	28.929	38.3661	16.9469
GO:0003729	mRNA binding	molecular_function	Escherichia	Escherichia coli	0	0	0.16342	0	0	0
GO:0003735	structural constituent of ribosome	molecular_function	Clostridium	Clostridium thermocellum	1124.36	7772.48	4272.95	24818.1	22466.8	28765.6
GO:0003735	structural constituent of ribosome	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7076.53	8854.01	6578.44	9683.54	10960.2	8803.02
GO:0003735	structural constituent of ribosome	molecular_function	Escherichia	Escherichia coli	1.85664	0	2.01147	0	0	0.489223
GO:0003735	structural constituent of ribosome	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	26.9733	77.1491	97.7281	103.776	54.8019	85.1355
GO:0003743	translation initiation factor activity	molecular_function	Clostridium	Clostridium thermocellum	15.4948	81.3768	66.6593	335.931	327.44	433.147
GO:0003743	translation initiation factor activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	186.109	192.414	183.507	190.529	201.449	172.004
GO:0003743	translation initiation factor activity	molecular_function	Escherichia	Escherichia coli	0.189815	0	1.12852	0	0	0.0256447
GO:0003743	translation initiation factor activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.31753	11.5555	4.02295	11.0023	5.56011	10.3248
GO:0003746	translation elongation factor activity	molecular_function	Clostridium	Clostridium thermocellum	77.4869	413.359	286.347	1635.73	1440.8	1509.42
GO:0003746	translation elongation factor activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	696.696	691.209	633.687	628.917	735.034	601.474
GO:0003746	translation elongation factor activity	molecular_function	Escherichia	Escherichia coli	0.147987	0	0.0273344	0	0	0.245161
GO:0003746	translation elongation factor activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.41697	4.47698	3.78708	5.4333	2.41122	8.48663
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	20.8325	125.125	91.5941	328.974	291.897	325.195
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7.12833	14.9748	13.5304	19.2067	19.5046	16.6573
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	molecular_function	Escherichia	Escherichia coli	0.103098	0	0.0942272	0	0	0
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.176107	0.154816	1.21823	0.869957	0.330232	1.1555
GO:0003756	protein disulfide isomerase activity	molecular_function	Escherichia	Escherichia coli	0.0814186	0	0	0	0	0
GO:0003774	motor activity	molecular_function	Clostridium	Clostridium thermocellum	16.2424	61.3966	47.157	457.11	413.752	330.428
GO:0003774	motor activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0527744	0	0	0.042849
GO:0003796	lysozyme activity	molecular_function	Escherichia	Escherichia coli	0.145265	0	0	0	0	0.0966933
GO:0003824	catalytic activity	molecular_function	Clostridium	Clostridium thermocellum	137.316	831.273	713.52	2195.99	1939.11	1950.29
GO:0003824	catalytic activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	545.528	655.862	594.009	462.651	556.504	442.548
GO:0003824	catalytic activity	molecular_function	Escherichia	Escherichia coli	7.69532	0	0.546509	0	0	2.76485
GO:0003824	catalytic activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	8.65781	16.738	10.6613	9.9622	6.538	10.5079
GO:0003825	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.162546	0.139181	0	0.0741876	0	0.0482173
GO:0003839	gamma-glutamylcyclotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0	1.46588	1.69992	1.48547	0.477746	0.915255
GO:0003840	gamma-glutamyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0455458	0	0	0	0	0
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	5.997	47.2479	28.0874	116.149	110.111	121.998
GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.8536	7.17812	8.30773	2.55001	3.206	4.34188
GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.00636766	0	0	0	0	0
GO:0003844	1,4-alpha-glucan branching enzyme activity	molecular_function	Clostridium	Clostridium thermocellum	1.36577	4.09104	3.84514	25.4212	28.2393	28.5431
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.06211	9.43031	7.26794	27.1576	18.0614	20.3111
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.95863	3.78878	2.34332	5.25814	5.82665	4.74163
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265619	0.339924	0.32851	0	0.11852	0.1767
GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	4.18625	33.5688	32.7505	51.4121	45.198	55.465
GO:0003852	2-isopropylmalate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	5.38225	20.4815	17.118	50.8821	40.6564	32.9352
GO:0003852	2-isopropylmalate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.391392	0.616792	0.364008	0.549779	0.158713	0.287396
GO:0003855	3-dehydroquinate dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	1.38574	7.35655	3.7173	17.0606	15.9985	19.0732
GO:0003855	3-dehydroquinate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.376178	0.904535	0.524316	0	0.336482	0.500897
GO:0003856	3-dehydroquinate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	1.74464	17.7563	9.18415	61.5516	42.0406	30.4581
GO:0003856	3-dehydroquinate synthase activity	molecular_function	Escherichia	Escherichia coli	0.155303	0	0	0	0	0
GO:0003856	3-dehydroquinate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123051	0.425617	0.274202	0.100799	0.109795	0.294898
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.172705	0	0	0	0	0.0158461
GO:0003861	3-isopropylmalate dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	4.98129	49.7019	32.4344	154.533	108.949	61.6607
GO:0003861	3-isopropylmalate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.137391	1.1134	0.36464	0.535603	0.278926	0.291018
GO:0003862	3-isopropylmalate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	3.41508	16.4448	10.2752	56.2522	42.2691	32.7029
GO:0003862	3-isopropylmalate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0963923	0	0	0
GO:0003862	3-isopropylmalate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0287031	0.110476	0	0.118009	0.0258265	0.0764815
GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	142.466	6.9546	14.7641	3.46147	3.02157	1.69925
GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.87409	6.84534	6.93312	13.2033	14.2757	17.5755
GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	28.2373	10.6405	11.762	11.5499	14.959	11.9443
GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0376713	0	0	0	0	0
GO:0003866	3-phosphoshikimate 1-carboxyvinyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	12.7106	54.7726	52.5702	144.858	144.756	140.053
GO:0003866	3-phosphoshikimate 1-carboxyvinyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0428724	0	0	0	0	0
GO:0003866	3-phosphoshikimate 1-carboxyvinyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0875918	0.168212	0.162563	0.0672239	0.0391087	0
GO:0003867	4-aminobutyrate transaminase activity	molecular_function	Escherichia	Escherichia coli	0.0217764	0	0.079748	0	0	0
GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0114958	0	0	0	0	0.0306249
GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0312793	0.120138	0.0580519	0.0640157	0.0837516	0.208101
GO:0003872	6-phosphofructokinase activity	molecular_function	Clostridium	Clostridium thermocellum	12.712	116.88	72.6404	379.328	344.769	269.537
GO:0003872	6-phosphofructokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	233.381	310.772	242.865	253.449	310.629	177.948
GO:0003872	6-phosphofructokinase activity	molecular_function	Escherichia	Escherichia coli	0.1493	0	0.0554808	0	0	0
GO:0003879	ATP phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.26044	0.569185	0.733068	4.23322	1.01539	0.85449
GO:0003879	ATP phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.21181	0	0.339561	0.227512	0.137748	0.441652
GO:0003882	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0402961	0	0	0	0	0
GO:0003883	CTP synthase activity	molecular_function	Clostridium	Clostridium thermocellum	2.99069	17.5081	9.72511	47.0376	51.3878	47.8895
GO:0003883	CTP synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	81.7573	30.9161	34.0033	28.7358	35.2159	18.6169
GO:0003883	CTP synthase activity	molecular_function	Escherichia	Escherichia coli	0.163323	0	0	0	0	0
GO:0003883	CTP synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.133915	0.514297	0.186334	0.582359	0.0896765	0.400873
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.14213	0	0	0
GO:0003887	DNA-directed DNA polymerase activity	molecular_function	Clostridium	Clostridium thermocellum	13.8017	113.47	81.4022	272.913	252.09	280.244
GO:0003887	DNA-directed DNA polymerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	193.276	136.463	164.902	92.8841	107.422	88.0927
GO:0003887	DNA-directed DNA polymerase activity	molecular_function	Escherichia	Escherichia coli	1.29939	0	1.62008	0	0	0.107753
GO:0003887	DNA-directed DNA polymerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.562687	1.89994	1.70858	1.80634	1.05574	5.6378
GO:0003896	DNA primase activity	molecular_function	Clostridium	Clostridium thermocellum	9.35849	55.0787	43.5957	155.68	132.08	144.945
GO:0003896	DNA primase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.8509	15.819	16.563	18.5483	22.5299	17.679
GO:0003896	DNA primase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0282817	0	0	0
GO:0003896	DNA primase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.702339	0.957976	0.737489	0.738419	0.33008	1.21966
GO:0003899	DNA-directed RNA polymerase activity	molecular_function	Clostridium	Clostridium thermocellum	31.4805	122.608	89.2892	472.668	417.922	393.303
GO:0003899	DNA-directed RNA polymerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	259.178	139.541	113.496	109.676	145.053	90.425
GO:0003899	DNA-directed RNA polymerase activity	molecular_function	Escherichia	Escherichia coli	0.140842	0	0.0232749	0	0	0.0166869
GO:0003899	DNA-directed RNA polymerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	24.7246	24.1352	16.6017	37.8499	10.3458	36.8199
GO:0003904	deoxyribodipyrimidine photo-lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265935	0.196403	0.151828	0	0.0730737	0
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	Clostridium	Clostridium thermocellum	8.44359	38.6602	41.3978	94.1453	87.3801	154.826
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	35.2144	18.7453	22.4538	18.0727	28.9692	25.5127
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	Escherichia	Escherichia coli	0.100011	0	0	0	0	0
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.164322	0.045388	0.235607	0.293152
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0	1.01576	2.62726	5.81001	3.04457	5.45528
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0	0.0848896
GO:0003909	DNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.090241	0	0.33505	0	0	0
GO:0003910	DNA ligase (ATP) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110778	0.060769	0.117502	0.145714	0.0847716	0.126316
GO:0003911	DNA ligase (NAD+) activity	molecular_function	Clostridium	Clostridium thermocellum	0.923554	8.33441	5.65561	19.559	20.7214	22.148
GO:0003911	DNA ligase (NAD+) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.0687	5.62109	6.50628	5.73657	6.64734	6.81345
GO:0003911	DNA ligase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.225396	0	0.0880927	0	0	0.0421052
GO:0003917	DNA topoisomerase type I activity	molecular_function	Clostridium	Clostridium thermocellum	2.98451	17.6204	11.4183	60.2139	61.4208	56.995
GO:0003917	DNA topoisomerase type I activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.2855	14.3293	10.8965	6.45138	6.94773	5.49076
GO:0003917	DNA topoisomerase type I activity	molecular_function	Escherichia	Escherichia coli	0.0198564	0	0.114796	0	0	0
GO:0003917	DNA topoisomerase type I activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.108979	0.0232435	0.179794	0.148649	0.194523	0.112798
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	6.78066	44.6972	34.4645	123.05	113.338	115.841
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.4792	32.5295	35.4333	25.4426	27.668	20.7157
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	Escherichia	Escherichia coli	0.11909	0	0.0995948	0	0	0
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.585217	2.24855	2.45496	0.509663	0.383816	0.268186
GO:0003919	FMN adenylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.18476	13.2453	14.3414	40.3507	33.9304	35.5191
GO:0003919	FMN adenylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.502	12.0994	6.78476	11.8856	12.0771	13.8432
GO:0003919	FMN adenylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0794256	0.457588	0.588683	1.70599	0.70834	0.422734
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	3.92593	27.1335	16.1024	89.4446	80.4397	68.3222
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	51.7973	29.7592	26.6445	20.2701	25.1246	15.1858
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	Escherichia	Escherichia coli	0.03405	0	0	0	0	0
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.122249	0.46977	0.616198	0.126564	0.298849	0.890322
GO:0003924	GTPase activity	molecular_function	Clostridium	Clostridium thermocellum	91.2264	448.433	297.561	1621.13	1364.53	1261.36
GO:0003924	GTPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	414.785	372.913	315.105	395.09	474.382	398.036
GO:0003924	GTPase activity	molecular_function	Escherichia	Escherichia coli	0.619389	0	0.12711	0	0	0.410316
GO:0003924	GTPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	9.81184	12.6318	10.4115	6.31087	3.93702	7.44855
GO:0003933	GTP cyclohydrolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0602254	0	0.0558868	0.614964	0.671163	0.801358
GO:0003934	GTP cyclohydrolase I activity	molecular_function	Clostridium	Clostridium thermocellum	2.75064	26.1507	22.8737	59.1885	55.363	59.7911
GO:0003934	GTP cyclohydrolase I activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.0869	27.9668	16.4539	22.0763	24.8876	25.081
GO:0003935	GTP cyclohydrolase II activity	molecular_function	Clostridium	Clostridium thermocellum	2.5136	14.1421	9.7049	36.0382	30.5943	26.5774
GO:0003937	IMP cyclohydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	1.53247	2.87719	2.16578	36.1461	27.8234	16.8718
GO:0003937	IMP cyclohydrolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0520107	0	0	0	0	0
GO:0003937	IMP cyclohydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0337826	0	0	0	0	0
GO:0003937	IMP cyclohydrolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.158851	0	0	0.433461	0.188729	0
GO:0003938	IMP dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	4.68312	31.4181	17.7155	99.2167	100.045	89.0826
GO:0003938	IMP dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	71.534	66.568	59.0969	42.1208	59.2179	36.5093
GO:0003938	IMP dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0369179	0	0	0	0	0
GO:0003938	IMP dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0745162	0.214605	0.449349	1.08578	0.133039	0.371444
GO:0003939	L-iditol 2-dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	1.04194	14.1858	11.3134	21.2411	23.4366	38.7121
GO:0003941	L-serine ammonia-lyase activity	molecular_function	Escherichia	Escherichia coli	0.311432	0	0.127967	0	0	0
GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	molecular_function	Clostridium	Clostridium thermocellum	2.68978	9.57094	10.6172	33.7309	29.9122	30.1183
GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.274417	0.316447	0.10176	0.224826	0.637198	0.219193
GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	molecular_function	Escherichia	Escherichia coli	0.0568472	0	0	0	0	0
GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.301395	0.104409	0.756839	0.862297	0.295637	0.733446
GO:0003949	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	9.34921	15.2183	14.147	55.5637	53.1404	46.2995
GO:0003949	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.585427	0	1.31747	0.181523	0.405918
GO:0003951	NAD+ kinase activity	molecular_function	Clostridium	Clostridium thermocellum	3.27337	43.3958	38.1945	99.6322	94.2849	136.194
GO:0003951	NAD+ kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	34.3566	43.1891	33.5009	24.7099	33.9442	25.1287
GO:0003951	NAD+ kinase activity	molecular_function	Escherichia	Escherichia coli	0.233368	0	0	0	0	0
GO:0003951	NAD+ kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.207727	0.398826	0.192649	0.070855	0.15459	0
GO:0003952	NAD+ synthase (glutamine-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	2.21493	7.67324	6.91007	20.1786	15.2167	15.9144
GO:0003952	NAD+ synthase (glutamine-hydrolyzing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	106.345	63.426	60.155	37.1686	45.6683	41.5932
GO:0003952	NAD+ synthase (glutamine-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0720129	0.276494	0.801901	0.294711	0.160819	0.670579
GO:0003954	NADH dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.1208	53.0885	39.1071	15.0276	21.1058	31.5373
GO:0003954	NADH dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0211688	0	0	0	0	0
GO:0003957	NAD(P)+ transhydrogenase (B-specific) activity	molecular_function	Escherichia	Escherichia coli	0.0953691	0	0.07208	0	0	0.0517099
GO:0003960	NADPH:quinone reductase activity	molecular_function	Escherichia	Escherichia coli	0.0582811	0	0	0	0	0
GO:0003961	O-acetylhomoserine aminocarboxypropyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.46716	11.5092	9.78537	35.8223	26.6286	19.0933
GO:0003962	cystathionine gamma-synthase activity	molecular_function	Escherichia	Escherichia coli	0.0480734	0	0	0	0	0
GO:0003963	RNA-3'-phosphate cyclase activity	molecular_function	Escherichia	Escherichia coli	0.0560695	0	0	0	0	0.0371574
GO:0003963	RNA-3'-phosphate cyclase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.224934	0.216099	0.208752	0.345421	0.175555	0.0748645
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	6.26833	35.7007	27.2547	96.8199	94.1636	84.6506
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.0894	14.1176	12.1005	34.4997	35.4584	19.8786
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.019905	0	0.0738842	0	0	0
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.151609	0.166391	0.200994	0.15514	0.116067	0.172948
GO:0003978	UDP-glucose 4-epimerase activity	molecular_function	Clostridium	Clostridium thermocellum	2.6548	27.3309	23.0112	46.6437	55.0428	57.194
GO:0003978	UDP-glucose 4-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0280226	0	0	0	0	0
GO:0003978	UDP-glucose 4-epimerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.117413	0.11267	0.108932	0.420429	0.104868	0.546495
GO:0003979	UDP-glucose 6-dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	2.60525	8.90187	7.53177	29.0305	27.0512	28.6638
GO:0003979	UDP-glucose 6-dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0404176	0.0387858	0.149934	0.0619763	0.0541271	0.0537796
GO:0003979	UDP-glucose 6-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.143394	0	0	0	0	0.0636106
GO:0003979	UDP-glucose 6-dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0636037	0.0813988	0.0787106	0.260141	0	0
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.00262	16.584	8.70638	40.1594	35.961	49.9037
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0869269
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.411541	1.18523	1.3379	0.63185	0.398466	0.410963
GO:0003984	acetolactate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	12.3166	82.6134	56.7822	225.977	186.613	134.043
GO:0003984	acetolactate synthase activity	molecular_function	Escherichia	Escherichia coli	0.128107	0	0	0	0	0
GO:0003984	acetolactate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.10232	0.131013	0.205685	0.961728	0.287716	0.197397
GO:0003985	acetyl-CoA C-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	26.0275	2.18932	2.51143	2.25821	2.2474	1.51585
GO:0003985	acetyl-CoA C-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0471013	0	0	0	0	0.0626728
GO:0003987	acetate-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0624857	0	0	0	0	0
GO:0003987	acetate-CoA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321105	0.603863	0.128914	0.461639	0	0.431271
GO:0003988	acetyl-CoA C-acyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0471013	0	0.0881829	0	0	0.0626728
GO:0003989	acetyl-CoA carboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	2.82617	21.9157	7.62902	73.9833	56.342	36.5976
GO:0003989	acetyl-CoA carboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.7308	24.1489	20.9167	25.6852	28.76	20.2805
GO:0003989	acetyl-CoA carboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0405149	0	0.431307	0	0	0.0539089
GO:0003991	acetylglutamate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.540085	2.86455	2.88893	11.9237	4.87905	5.78973
GO:0003991	acetylglutamate kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.103581
GO:0003991	acetylglutamate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.331896	0.127419	0.184846	0.203761	0.237191	0.353367
GO:0003992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.22298	3.18963	1.49848	18.1541	7.37558	5.86201
GO:0003992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0217764	0	0.079748	0	0	0
GO:0003992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.118774	0.319248	0.264549	0.170087	0.212016	0.56897
GO:0003993	acid phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	20.2842	21.6924	22.903	67.0532	58.2092	73.6737
GO:0003993	acid phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.114674
GO:0003994	aconitate hydratase activity	molecular_function	Clostridium	Clostridium thermocellum	1.10559	12.6957	13.5628	26.4564	26.7358	26.7353
GO:0003994	aconitate hydratase activity	molecular_function	Escherichia	Escherichia coli	0.00991605	0	0	0	0	0
GO:0003995	acyl-CoA dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.178829	0	0.0908442	0	0	0.315563
GO:0003999	adenine phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	5.3083	25.8836	13.0491	63.7916	59.4961	59.5095
GO:0003999	adenine phosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	82.9271	58.608	43.511	37.0193	45.5653	50.1944
GO:0003999	adenine phosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.224404	0	0	0
GO:0004000	adenosine deaminase activity	molecular_function	Escherichia	Escherichia coli	0.028533	0	0	0	0	0
GO:0004003	ATP-dependent DNA helicase activity	molecular_function	Clostridium	Clostridium thermocellum	8.84993	39.5339	36.4808	92.6987	88.1387	100.731
GO:0004003	ATP-dependent DNA helicase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	12.2596	9.9679	9.19547	12.8521	13.1056	10.1141
GO:0004003	ATP-dependent DNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.170104	0	0.269691	0	0	0.0384186
GO:0004003	ATP-dependent DNA helicase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.076655	0.0736043	0	0.117685	0.0456412	0.136017
GO:0004004	ATP-dependent RNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.160625	0	0.14619	0	0	0.1496
GO:0004008	copper-exporting ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.9607	6.2729799999999996	12.8348	2.63258	3.93105	6.52706
GO:0004013	adenosylhomocysteinase activity	molecular_function	Clostridium	Clostridium thermocellum	4.23802	22.4967	18.8175	78.4721	77.705	67.3157
GO:0004013	adenosylhomocysteinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.9332	21.8965	19.3373	29.1334	37.6344	21.9112
GO:0004013	adenosylhomocysteinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.169052	0.0817327	0.315378	0.196498	0.263659
GO:0004014	adenosylmethionine decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	17.8211	150.459	93.7517	655.139	644.823	950.994
GO:0004014	adenosylmethionine decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	91.4887	110.189	143.464	72.4909	93.239	81.7297
GO:0004014	adenosylmethionine decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0699148	0	0	0.0501253
GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0595449	0.0762647	0.405281	0.710987	0.726831	0.501964
GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	molecular_function	Escherichia	Escherichia coli	0.0448653	0	0.0833114	0	0	0
GO:0004016	adenylate cyclase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0269706
GO:0004017	adenylate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	4.57971	10.556	6.43956	78.6257	34.4591	32.6999
GO:0004017	adenylate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	48.9564	13.5506	11.9735	20.7761	29.4811	23.4327
GO:0004017	adenylate kinase activity	molecular_function	Escherichia	Escherichia coli	0.147307	0	0	0	0	0
GO:0004017	adenylate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.22209	0	1.10759	0.351738	0.366345	0.880976
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	molecular_function	Clostridium	Clostridium thermocellum	2.56609	19.096	13.0901	53.6147	49.7911	53.0492
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	4.73713	3.81776	2.90485	3.76601	3.22935	2.67336
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	molecular_function	Escherichia	Escherichia coli	0.03981	0	0	0	0	0
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.121496	0.350005	0.563694	0.559503	0.14465	0.107786
GO:0004019	adenylosuccinate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	3.47798	25.0905	23.5623	91.833	104.184	82.8417
GO:0004019	adenylosuccinate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	28.881	17.4687	14.6117	19.1518	24.4513	19.9258
GO:0004019	adenylosuccinate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0634579	0	0	0	0	0
GO:0004019	adenylosuccinate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.167042	0.107163	0.774972	1.16755	0.6956	1.11123
GO:0004020	adenylylsulfate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.117826	27.1204	16.2624	73.8219	53.4032	41.2491
GO:0004020	adenylylsulfate kinase activity	molecular_function	Escherichia	Escherichia coli	0.108032	0	0	0	0	0
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0446465	0	0	0	0	0
GO:0004022	alcohol dehydrogenase (NAD) activity	molecular_function	Clostridium	Clostridium thermocellum	0.658664	16.1959	9.70495	72.5495	65.9282	34.2944
GO:0004022	alcohol dehydrogenase (NAD) activity	molecular_function	Escherichia	Escherichia coli	0.0920395	0	0.0900323	0	0	0
GO:0004029	aldehyde dehydrogenase (NAD) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.8536	7.17812	8.30773	2.55001	3.206	4.34188
GO:0004029	aldehyde dehydrogenase (NAD) activity	molecular_function	Escherichia	Escherichia coli	0.348447	0	0.200453	0	0	0
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	molecular_function	Clostridium	Clostridium thermocellum	0.229819	2.94146	1.49279	7.42607	6.99288	7.20601
GO:0004033	aldo-keto reductase (NADP) activity	molecular_function	Escherichia	Escherichia coli	0.0585242	0	0	0	0	0.114189
GO:0004034	aldose 1-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0545626	0	0	0	0	0
GO:0004038	allantoinase activity	molecular_function	Escherichia	Escherichia coli	0.0191516	0	0	0	0	0.0947853
GO:0004040	amidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.61867	0.933472	0.451064	0.0826185	0.144693	0
GO:0004040	amidase activity	molecular_function	Escherichia	Escherichia coli	0.069461	0	0.386697	0	0	0.0478939
GO:0004042	acetyl-CoA:L-glutamate N-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.01251	3.48787	2.17638	14.6388	12.8624	11.5721
GO:0004042	acetyl-CoA:L-glutamate N-acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0917964	0.661038	0.553229	0.375812	0.122947	0.427488
GO:0004044	amidophosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.51317	2.48047	0.993152	14.8184	20.047	15.0013
GO:0004044	amidophosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.168962	0.215445	0.174381	0.115397	0.268508	0.325038
GO:0004044	amidophosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0710651	0	0	0	0	0
GO:0004044	amidophosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.114351	0	0.141499	0.175533	0.0340519	0.0760934
GO:0004045	aminoacyl-tRNA hydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	1.21345	6.76945	3.54229	13.4902	13.2259	14.2407
GO:0004045	aminoacyl-tRNA hydrolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.15117	7.60504	6.4982	7.70994	8.85166	7.6867
GO:0004047	aminomethyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	124.331	83.1919	115.231	65.8005	80.3797	46.756100000000004
GO:0004048	anthranilate phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.52973	28.3747	61.0337	96.7238	64.2943	66.0053
GO:0004048	anthranilate phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.801937	0.102682	0	0.246214	0.119388	1.10276
GO:0004049	anthranilate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	1.0371	8.84292	23.4419	51.5684	39.9127	91.704
GO:0004049	anthranilate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0925498	0	0	0	0	0
GO:0004049	anthranilate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.422526	0	0.0724408	0	0.0840771	0.510275
GO:0004055	argininosuccinate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.842014	1.79147	1.39365	14.9205	6.33647	8.23416
GO:0004055	argininosuccinate synthase activity	molecular_function	Escherichia	Escherichia coli	0.101785	0	0.0755531	0	0	0
GO:0004055	argininosuccinate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.231375	0.666779	0.171855	0.378971	0.082623	0.307996
GO:0004056	argininosuccinate lyase activity	molecular_function	Clostridium	Clostridium thermocellum	1.62409	2.70049	1.06591	12.8661	7.55014	6.66527
GO:0004056	argininosuccinate lyase activity	molecular_function	Escherichia	Escherichia coli	0.0198564	0	0	0	0	0
GO:0004056	argininosuccinate lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.193217	0.185668	0.179343	0.197842	0.120864	0.0257418
GO:0004061	arylformamidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.5656	12.5449	8.71175	11.5431	10.73	8.61288
GO:0004061	arylformamidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.320352	0.531379	0.222735	0.184064	0.107169	0.319411
GO:0004065	arylsulfatase activity	molecular_function	Escherichia	Escherichia coli	0.0322758	0	0.0299506	0	0	0
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	0.0574548	0.220626	0.106631	0.26422	0.205223	0.324909
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0771897	0.074071	0.286425	0.176802	0.0344425	0.256641
GO:0004067	asparaginase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.5423	18.0342	17.5276	4.73572	8.79582	14.1388
GO:0004067	asparaginase activity	molecular_function	Escherichia	Escherichia coli	0.195113	0	0.105549	0	0	0.0360579
GO:0004067	asparaginase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.230816	0.0805587	0	0.128802	0.0562323	0.0837254
GO:0004068	aspartate 1-decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	2.52193	14.4972	11.4945	32.9542	31.4178	34.2164
GO:0004068	aspartate 1-decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.9563	26.9304	27.2579	21.9174	19.4253	18.9558
GO:0004068	aspartate 1-decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0258109	0.148609	0	0.369296	0.115025	0
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.304384	15.5106	12.4246	54.3206	58.0849	85.4305
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	50.0765	13.7323	32.6144	4.60319	5.75173	6.46044
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0466881	0	0	0	0	0
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0498233	0.0956809	0.138792	0.561145	0.133625	0.0995068
GO:0004070	aspartate carbamoyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.431203	4.66759	5.1447	9.77018	11.9337	15.5682
GO:0004070	aspartate carbamoyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.8177	1.71465	2.95952	0.522123	0.484192	0.339526
GO:0004070	aspartate carbamoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.217157	0	0	0	0	0
GO:0004070	aspartate carbamoyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123222	0.0591355	0.171494	0.0630458	0.10999	0.245873
GO:0004071	aspartate-ammonia ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.00423	11.0108	9.29827	27.4214	27.3095	32.9501
GO:0004071	aspartate-ammonia ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.43158	29.0199	18.8658	23.913	24.1686	9.43613
GO:0004071	aspartate-ammonia ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.452292
GO:0004072	aspartate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.41736	14.388	11.0114	56.7087	52.8687	48.2522
GO:0004072	aspartate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0405149	0.155563	0.225261	0.0414585	0.253186	0.134724
GO:0004072	aspartate kinase activity	molecular_function	Escherichia	Escherichia coli	0.103535	0	0.0395132	0	0	0
GO:0004072	aspartate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.113476	0.392152	0.421158	0.4643	0.121623	0.422508
GO:0004073	aspartate-semialdehyde dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	2.11693	7.52813	8.59258	20.3668	24.8744	25.0777
GO:0004073	aspartate-semialdehyde dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.274417	0.316447	0.10176	0.224826	0.637198	0.219193
GO:0004073	aspartate-semialdehyde dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.244572	0.104409	0.756839	0.862297	0.194176	0.506492
GO:0004075	biotin carboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0405149	0	0.150294	0	0	0.0539089
GO:0004075	biotin carboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.183277	0.175073	0.272127	0.262579	0.130934	0.292602
GO:0004076	biotin synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.059788	0.287043	0.219803	0.64155	0.879272	1.82951
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	114.816	175.867	339.038	76.677	89.1209	71.4393
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	molecular_function	Escherichia	Escherichia coli	0.178999	0	0	0	0	0
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.229212	0.51369	0.424992	0.70375	0.409274	0.101706
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	2.04589	9.22471	6.84268	32.5625	32.4153	26.6028
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	molecular_function	Escherichia	Escherichia coli	0.0316439	0	0.0586834	0	0	0
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.089682	0.382817	0	0.166978	0.199775	0.78784
GO:0004089	carbonate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.189401	0	0.176005	0	0	0
GO:0004089	carbonate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.229307	0.236763	0.392003	0.113919	0.848346
GO:0004096	catalase activity	molecular_function	Escherichia	Escherichia coli	0.0460319	0	0	0	0	0
GO:0004106	chorismate mutase activity	molecular_function	Escherichia	Escherichia coli	0.0721101	0	0	0	0	0
GO:0004106	chorismate mutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.16534	0	0.306859	0	0.420168	0.432759
GO:0004107	chorismate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	5.75051	25.0653	17.4271	71.0047	56.8645	73.0903
GO:0004107	chorismate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.821817	1.10047	0.647006	0.841605	0.222477	0.431142
GO:0004108	citrate (Si)-synthase activity	molecular_function	Escherichia	Escherichia coli	0.0206827	0	0	0	0	0
GO:0004109	coproporphyrinogen oxidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.562736	5.12201	2.95248	9.71208	10.8358	8.56095
GO:0004109	coproporphyrinogen oxidase activity	molecular_function	Escherichia	Escherichia coli	0.0323973	0	0.0368519	0	0	0
GO:0004112	cyclic-nucleotide phosphodiesterase activity	molecular_function	Escherichia	Escherichia coli	0.04924	0	0.049932699999999997	0	0	0
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	molecular_function	Clostridium	Clostridium thermocellum	2.05304	14.8595	15.0335	28.6236	25.8995	31.0351
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.57913	6.22052	4.92814	6.42321	4.33271	8.69916
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.718792	0.460995	0.222735	0.429706	0	0
GO:0004121	cystathionine beta-lyase activity	molecular_function	Escherichia	Escherichia coli	0.0234048	0	0.0854314	0	0	0
GO:0004124	cysteine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	7.50952	930.533	633.388	1444.67	1267.68	1095.07
GO:0004124	cysteine synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.37537	20.7263	18.0253	14.2907	15.7527	11.2618
GO:0004124	cysteine synthase activity	molecular_function	Escherichia	Escherichia coli	0.0662285	0	0.109744	0	0	0
GO:0004125	L-seryl-tRNASec selenium transferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.0747	16.9223	13.8159	13.3391	14.8082	17.0092
GO:0004125	L-seryl-tRNASec selenium transferase activity	molecular_function	Escherichia	Escherichia coli	0.0976294	0	0	0	0	0
GO:0004126	cytidine deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	5.42019	15.356	8.18067	52.5126	48.2299	47.6837
GO:0004126	cytidine deaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.32507	6.71358	4.44036	6.02628	7.87614	12.1276
GO:0004127	cytidylate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	6.82242	51.3493	27.5884	104.762	118.867	125.629
GO:0004127	cytidylate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.2649	18.5374	13.7887	25.9076	30.2487	22.0955
GO:0004127	cytidylate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0723289	0.138901	0	0.740408	0.38718	0.77083
GO:0004129	cytochrome-c oxidase activity	molecular_function	Escherichia	Escherichia coli	0.196595	0	0	0	0	0
GO:0004130	cytochrome-c peroxidase activity	molecular_function	Escherichia	Escherichia coli	0.198613	0	0.071674	0	0	0
GO:0004133	glycogen debranching enzyme activity	molecular_function	Escherichia	Escherichia coli	0.079936	0	0.148355	0	0	0
GO:0004134	4-alpha-glucanotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.08846	8.18431	6.03654	29.6421	28.7723	30.4393
GO:0004134	4-alpha-glucanotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0251304	0	0	0	0	0
GO:0004135	amylo-alpha-1,6-glucosidase activity	molecular_function	Clostridium	Clostridium thermocellum	1.08846	8.18431	6.03654	29.6421	28.7723	30.4393
GO:0004139	deoxyribose-phosphate aldolase activity	molecular_function	Clostridium	Clostridium thermocellum	2.09353	22.1003	15.1099	60.3665	37.74	60.8098
GO:0004139	deoxyribose-phosphate aldolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.2405	14.345	7.7744	13.2134	16.1646	16.8584
GO:0004139	deoxyribose-phosphate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.0771654	0	0	0	0	0
GO:0004139	deoxyribose-phosphate aldolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.370175	0.347438	0.257738	0.142033	0.0826881	0.18514
GO:0004140	dephospho-CoA kinase activity	molecular_function	Clostridium	Clostridium thermocellum	2.54852	12.0212	9.16164	26.7003	25.1749	24.24
GO:0004140	dephospho-CoA kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.53013	6.91068	3.33331	8.45888	9.64143	9.6497
GO:0004141	dethiobiotin synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0830956	0	0	0.339875	0.296787	0.663271
GO:0004141	dethiobiotin synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.11836
GO:0004146	dihydrofolate reductase activity	molecular_function	Clostridium	Clostridium thermocellum	4.66723	34.7584	21.8931	95.8256	97.9612	69.4259
GO:0004148	dihydrolipoyl dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.81986	2.76564	3.19249	2.90617	2.96503	2.71446
GO:0004148	dihydrolipoyl dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0707719	0	0	0
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	202.561	37.4275	53.072	10.7665	10.0237	12.0631
GO:0004150	dihydroneopterin aldolase activity	molecular_function	Clostridium	Clostridium thermocellum	1.92063	7.73797	5.93419	21.7524	18.4385	14.4682
GO:0004150	dihydroneopterin aldolase activity	molecular_function	Escherichia	Escherichia coli	0.221945	0	0	0	0	0
GO:0004150	dihydroneopterin aldolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.379456	1.09942	0.202194	0	0.262398
GO:0004151	dihydroorotase activity	molecular_function	Clostridium	Clostridium thermocellum	1.30386	9.1113	8.84441	22.6345	29.5918	35.1093
GO:0004151	dihydroorotase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.34572	1.02869	2.06898	0.776396	0.219221	0.0890936
GO:0004151	dihydroorotase activity	molecular_function	Escherichia	Escherichia coli	0.054198	0	0	0	0	0
GO:0004151	dihydroorotase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0200022	0.230381	0.222735	0.307022	0.0893075	0.319411
GO:0004152	dihydroorotate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	0.785021	5.36028	4.36413	21.353	15.7481	14.4096
GO:0004152	dihydroorotate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0564583	0	0	0	0	0
GO:0004152	dihydroorotate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159386	0.122518	0.118404	0.195778	0.113897	0.0848896
GO:0004156	dihydropteroate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	3.17853	10.1689	6.98535	21.5581	22.3	22.5492
GO:0004156	dihydropteroate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.40281	14.4801	9.31383	15.9327	17.7981	11.6153
GO:0004156	dihydropteroate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0695339	0	0	0	0	0
GO:0004159	dihydrouracil dehydrogenase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0414076	0	0	0.0593419
GO:0004160	dihydroxy-acid dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	2.51826	20.572	13.8411	60.3785	49.4916	39.8605
GO:0004160	dihydroxy-acid dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0267345	0	0	0	0	0
GO:0004160	dihydroxy-acid dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.147283	0.989854	0.273344	0.583702	0.164334	0.465163
GO:0004161	dimethylallyltranstransferase activity	molecular_function	Escherichia	Escherichia coli	0.129589	0	0	0	0	0
GO:0004164	diphthine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.139875	0	0	0.200404
GO:0004165	dodecenoyl-CoA delta-isomerase activity	molecular_function	Escherichia	Escherichia coli	0.0357513	0	0	0	0	0.0158461
GO:0004170	dUTP diphosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.62402	13.6576	7.89036	6.861	7.59871	11.9597
GO:0004170	dUTP diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0786479	0	0	0	0	0
GO:0004170	dUTP diphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159119	0.308093	0	0	0.143261	0
GO:0004175	endopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.203012	0	0	0	0	0.0379012
GO:0004175	endopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.488463	0.781783	0.453319	0.166505	0.217876	1.0818
GO:0004176	ATP-dependent peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	4.95467	17.5277	18.7012	53.4906	45.2308	49.6649
GO:0004176	ATP-dependent peptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.3745	14.8853	9.86895	18.6179	26.4482	29.9665
GO:0004176	ATP-dependent peptidase activity	molecular_function	Escherichia	Escherichia coli	0.585874	0	0.60456	0	0	0.0471824
GO:0004176	ATP-dependent peptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.613459	1.5799	1.39239	0.716359	0.489531	1.12297
GO:0004177	aminopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	6.52338	33.8588	27.6728	99.6169	87.4209	80.2233
GO:0004177	aminopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.3144	39.9123	41.5584	47.7174	50.0259	34.6273
GO:0004177	aminopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.194821	0	0.371315	0	0	0
GO:0004177	aminopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110195	0.105762	0.102301	0.366511	0.196759	0.733058
GO:0004180	carboxypeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0897063	0	0	0	0	0.0341175
GO:0004181	metallocarboxypeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	33.8926	23.6485	24.7139	38.9734	42.7442	26.4803
GO:0004190	aspartic-type endopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	21.8414	96.3971	62.0178	368.632	291.859	289.646
GO:0004190	aspartic-type endopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	104.23	59.6735	47.479	43.7817	52.6735	56.0565
GO:0004190	aspartic-type endopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.849645	0	0	0	0	0
GO:0004190	aspartic-type endopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.07835	1.61271	5.19237	1.59216	2.42495	1.77107
GO:0004222	metalloendopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	15.874	79.6823	65.1974	234.733	226.917	228.067
GO:0004222	metalloendopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	280.168	233.463	295.625	157.125	171.002	163.369
GO:0004222	metalloendopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.29211	0	0.248852	0	0	0.0703371
GO:0004222	metalloendopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.15421	1.34845	1.12676	3.13577	0.79921	4.04883
GO:0004252	serine-type endopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	32.0261	257.514	160.382	614.062	532.614	748.355
GO:0004252	serine-type endopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	495.191	371.733	627.56	174.649	233.427	174.943
GO:0004252	serine-type endopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.754325	0	0.272623	0	0	0.21971
GO:0004252	serine-type endopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.613459	2.02283	2.14688	0.923179	0.541379	1.27752
GO:0004298	threonine-type endopeptidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0846632
GO:0004298	threonine-type endopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.790368	1.07172	0.82689	0.629488	0.217876	1.14874
GO:0004300	enoyl-CoA hydratase activity	molecular_function	Escherichia	Escherichia coli	0.0966572	0	0	0	0	0.0158461
GO:0004309	exopolyphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0349249	0	0.0648178	0	0	0
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	4.29596	11.3359	4.24667	85.2315	53.6559	45.0018
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	Clostridium	Clostridium thermocellum	13.9962	56.5422	38.7914	236.158	186.647	180.736
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.1284	22.1086	22.0817	16.7251	18.9639	12.4709
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	Clostridium	Clostridium thermocellum	2.86256	6.83302	2.50403	67.1869	44.9456	42.0939
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	121.523	15.1214	19.827	18.5345	28.8193	18.2567
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	Escherichia	Escherichia coli	0	0	0.150204	0	0	0
GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity	molecular_function	Clostridium	Clostridium thermocellum	1.23664	9.73149	5.3981	27.9807	25.9851	38.4535
GO:0004322	ferroxidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.27587	0	0	0.197785
GO:0004324	ferredoxin-NADP+ reductase activity	molecular_function	Escherichia	Escherichia coli	0.0814186	0	0.453319	0	0	0
GO:0004325	ferrochelatase activity	molecular_function	Escherichia	Escherichia coli	0.119552	0	0	0	0	0
GO:0004326	tetrahydrofolylpolyglutamate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	1.90938	12.2046	10.0561	43.7291	32.8488	33.8704
GO:0004326	tetrahydrofolylpolyglutamate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	76.9235	54.7017	38.7805	48.2917	49.3431	42.4473
GO:0004326	tetrahydrofolylpolyglutamate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.39985	0.994475	0.936498	0.632447	0.335809	0.891616
GO:0004329	formate-tetrahydrofolate ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.90737	9.78498	7.73804	28.1126	23.9058	24.062
GO:0004329	formate-tetrahydrofolate ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	116.739	31.9796	72.7909	21.6495	34.3175	33.1361
GO:0004332	fructose-bisphosphate aldolase activity	molecular_function	Clostridium	Clostridium thermocellum	9.251	187.596	131.683	467.604	448.693	467.214
GO:0004332	fructose-bisphosphate aldolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	61.2687	66.3204	53.7575	64.3077	73.8739	48.3358
GO:0004332	fructose-bisphosphate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.0598123	0	0	0	0	0.0716306
GO:0004333	fumarate hydratase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.06784	0	0	0.042752
GO:0004337	geranyltranstransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.70006	13.6808	8.69064	41.837	38.7719	33.1491
GO:0004337	geranyltranstransferase activity	molecular_function	Escherichia	Escherichia coli	0.129589	0	0	0	0	0
GO:0004340	glucokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	31.7165	38.3485	36.1946	39.8729	59.346	47.8904
GO:0004340	glucokinase activity	molecular_function	Escherichia	Escherichia coli	0.187263	0	0.404198	0	0	0
GO:0004342	glucosamine-6-phosphate deaminase activity	molecular_function	Escherichia	Escherichia coli	0.244256	0	0	0	0	0.0564314
GO:0004345	glucose-6-phosphate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0366505	0	0.0680204	0	0	0
GO:0004347	glucose-6-phosphate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	0.933883	12.0841	9.94279	33.4172	28.8943	27.7916
GO:0004347	glucose-6-phosphate isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	103.329	36.5149	39.0852	43.9878	53.5191	43.192
GO:0004348	glucosylceramidase activity	molecular_function	Clostridium	Clostridium thermocellum	1.10134	2.62324	4.47595	5.63485	5.90085	6.5278
GO:0004349	glutamate 5-kinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.34997	13.8472	9.75601	30.13	25.187	30.716
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	9.73207	35.5493	23.6101	77.5871	69.8801	71.8028
GO:0004351	glutamate decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.27867	0	0	0	0	0.0517099
GO:0004352	glutamate dehydrogenase (NAD+) activity	molecular_function	Clostridium	Clostridium thermocellum	4.32724	174.766	121.684	499.061	586.866	816.546
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.4938	24.2408	42.0628	7.5644	12.1989	20.408
GO:0004355	glutamate synthase (NADPH) activity	molecular_function	Clostridium	Clostridium thermocellum	0.0358485	4.2676	11.7037	15.034	23.2169	30.3742
GO:0004355	glutamate synthase (NADPH) activity	molecular_function	Escherichia	Escherichia coli	0.0766064	0	0	0	0	0
GO:0004355	glutamate synthase (NADPH) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.295076	0.463002	0.367572	1.10774	0.474339	0.297194
GO:0004356	glutamate-ammonia ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.61341	25.5983	44.598	110.996	113.311	124.708
GO:0004356	glutamate-ammonia ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	89.8945	66.5803	94.2909	35.8416	41.9936	38.8995
GO:0004356	glutamate-ammonia ligase activity	molecular_function	Escherichia	Escherichia coli	0.212272	0	0	0	0	0
GO:0004356	glutamate-ammonia ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.12344	0.0791584	0.229546	0.126465	0.0368081	0.164573
GO:0004357	glutamate-cysteine ligase activity	molecular_function	Escherichia	Escherichia coli	0.0496775	0	0	0	0	0
GO:0004358	glutamate N-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.01251	3.48787	2.17638	14.6388	12.8624	11.5721
GO:0004358	glutamate N-acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0917964	0.661038	0.553229	0.375812	0.122947	0.427488
GO:0004359	glutaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.81992	2.297	3.14567	4.0931	4.72397	2.14135
GO:0004359	glutaminase activity	molecular_function	Escherichia	Escherichia coli	0.0933519	0	0	0	0	0
GO:0004359	glutaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.143807	1.02075	0.420797	1.67843	0.287976	1.1316
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	molecular_function	Clostridium	Clostridium thermocellum	2.87425	5.07356	2.99064	34.4445	23.9786	17.6544
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.418	12.2322	8.50232	16.6672	18.6474	15.7124
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	molecular_function	Escherichia	Escherichia coli	0.0289704	0	0	0	0	0
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.119795	0.431311	0.305731	0.612874	0.320878	0.91629
GO:0004362	glutathione-disulfide reductase activity	molecular_function	Escherichia	Escherichia coli	0.0403933	0	0.0750119	0	0	0
GO:0004363	glutathione synthase activity	molecular_function	Escherichia	Escherichia coli	0.0606872	0	0.338929	0	0	0
GO:0004364	glutathione transferase activity	molecular_function	Escherichia	Escherichia coli	0.197665	0	0	0	0	0
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	Clostridium	Clostridium thermocellum	17.096	273.205	178.609	832.438	876.47	711.732
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	72.3995	272.804	209.82	182.612	265.605	187.264
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	Escherichia	Escherichia coli	0.114545	0	0	0	0	0
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.280858	0.37815	0.41764	0.143899	0.226014	0.823283
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	molecular_function	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.221021	0.396106	0	0
GO:0004370	glycerol kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.673538	4.71838	7.36433	1.45279	1.78719	2.7848
GO:0004370	glycerol kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0004371	glycerone kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.0015	40.5883	39.0635	39.6642	46.5421	34.0083
GO:0004371	glycerone kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0350877
GO:0004372	glycine hydroxymethyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.54412	52.7806	35.9423	179.599	189.141	149.235
GO:0004372	glycine hydroxymethyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.6804	11.9841	12.0337	8.85192	9.73997	6.94814
GO:0004372	glycine hydroxymethyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.106889	0.164198	0.236042	0.436595	0.0381754	0.0853423
GO:0004373	glycogen (starch) synthase activity	molecular_function	Clostridium	Clostridium thermocellum	3.25983	22.9129	16.1641	176.137	163.855	141.991
GO:0004373	glycogen (starch) synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	25.1303	18.9059	16.8647	23.5169	27.9081	19.338
GO:0004373	glycogen (starch) synthase activity	molecular_function	Escherichia	Escherichia coli	0.0567743	0	0	0	0	0
GO:0004375	glycine dehydrogenase (decarboxylating) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	476.331	101.139	151.15	106.948	128.231	86.6769
GO:0004385	guanylate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	6.36256	43.2792	39.5261	90.7204	102.094	88.9995
GO:0004385	guanylate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.54212	5.69572	8.38789	2.93569	5.3372	3.63437
GO:0004386	helicase activity	molecular_function	Clostridium	Clostridium thermocellum	25.7281	56.9332	61.8204	146.024	134.366	154.195
GO:0004386	helicase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	105.601	85.1105	86.6728	103.951	114.248	58.8483
GO:0004386	helicase activity	molecular_function	Escherichia	Escherichia coli	0.155279	0	0.0812816	0	0	0
GO:0004386	helicase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.695193	1.11107	0.67001	0.69517	0.403913	0.703759
GO:0004399	histidinol dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	6.8615	3.66701	2.49149	5.92521	5.05713	9.77171
GO:0004399	histidinol dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0420946	0	0	0	0	0
GO:0004399	histidinol dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0644787	0	0.079748	0.0879905	0.0191854	0.257353
GO:0004400	histidinol-phosphate transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	4.56046	1.96286	3.3081	6.08756	5.57112	11.4018
GO:0004400	histidinol-phosphate transaminase activity	molecular_function	Escherichia	Escherichia coli	0.0263942	0	0	0	0	0
GO:0004400	histidinol-phosphate transaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0750023	0	0	0.204656	0.13395	0
GO:0004401	histidinol-phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	0.225031	10.0075	4.38492	23.3951	23.3628	20.5036
GO:0004401	histidinol-phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.5271	7.66759	4.65114	5.86783	5.8383	4.92968
GO:0004401	histidinol-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0704018
GO:0004410	homocitrate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.18198	0.0879123	0.242384	0.0846197	0
GO:0004412	homoserine dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	2.21332	13.9762	11.2052	43.3594	50.9134	49.5504
GO:0004412	homoserine dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0420217	0	0.0395132	0	0	0
GO:0004412	homoserine dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.55282	0.38025	0.620257	0.26907	0.176814	0.670288
GO:0004413	homoserine kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.115202	0	0	0
GO:0004414	homoserine O-acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.120013	0.40284	0.333381	0.368252	0	0.239502
GO:0004416	hydroxyacylglutathione hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.226611	0	0.148851	0	0	0
GO:0004417	hydroxyethylthiazole kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0366505	0.0703838	0	0.0750332	0	0
GO:0004418	hydroxymethylbilane synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.233319	3.13586	4.32944	6.23263	4.85062	5.67706
GO:0004418	hydroxymethylbilane synthase activity	molecular_function	Escherichia	Escherichia coli	0.0613677	0	0.0569693	0	0	0
GO:0004418	hydroxymethylbilane synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.129659	0	0.241738	0.241185	0.26948
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0465666	0.357427	0	0.0476512	0.12349	0.0309807
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.189037	0.259319	0	0.193415	0.192787	0.215506
GO:0004422	hypoxanthine phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.33922	13.577	10.8916	51.0264	39.3707	68.6689
GO:0004422	hypoxanthine phosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.76042	9.12357	11.0711	12.0851	15.1185	13.2017
GO:0004422	hypoxanthine phosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.125603	0	0.23311	0	0	0.309904
GO:0004422	hypoxanthine phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.634761	0.307761	0.0564054	0.0984227	0
GO:0004424	imidazoleglycerol-phosphate dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	4.49285	14.2685	9.9759	44.5942	43.9294	63.3729
GO:0004424	imidazoleglycerol-phosphate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0704018
GO:0004424	imidazoleglycerol-phosphate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.121538	0	0.452213	0	0.414617
GO:0004425	indole-3-glycerol-phosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	2.57266	24.0192	61.392	115.516	61.6443	41.812
GO:0004425	indole-3-glycerol-phosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0401989	0	0.403341	0	0	0
GO:0004425	indole-3-glycerol-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.254245	0	0	0.297397	0.0648917	0.0966933
GO:0004427	inorganic diphosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	350.8	83.2577	135.248	37.9121	46.7459	53.6946
GO:0004427	inorganic diphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.122518	0	0.19547900000000001	0.170889	0.169747
GO:0004450	isocitrate dehydrogenase (NADP+) activity	molecular_function	Clostridium	Clostridium thermocellum	2.4552	47.411	32.8214	119.773	121.21	121.8
GO:0004450	isocitrate dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.301249	0	0	0	0	0
GO:0004452	isopentenyl-diphosphate delta-isomerase activity	molecular_function	Escherichia	Escherichia coli	0.121836	0	0	0	0	0
GO:0004452	isopentenyl-diphosphate delta-isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.440599	0	0.071857
GO:0004455	ketol-acid reductoisomerase activity	molecular_function	Clostridium	Clostridium thermocellum	5.22625	45.7734	22.807	155.133	139.625	109.7
GO:0004455	ketol-acid reductoisomerase activity	molecular_function	Escherichia	Escherichia coli	0.0916506	0	0	0	0	0
GO:0004455	ketol-acid reductoisomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.256699	0.273834	0.529368	0.640953	0.433017	0.719961
GO:0004457	lactate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.048681	0	0	0	0	0
GO:0004459	L-lactate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	3.46493	69.7876	42.5249	207.81	224.645	241.768
GO:0004462	lactoylglutathione lyase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.198108
GO:0004467	long-chain fatty acid-CoA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.50654	10.064	9.61261	31.4217	29.0526	26.3609
GO:0004467	long-chain fatty acid-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0334181	0	0	0	0	0
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	Clostridium	Clostridium thermocellum	3.60944	42.0489	25.6481	168.701	165.262	118.091
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.7036	8.48671	7.60015	8.90226	8.78091	8.77558
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.0541008	0	0	0	0	0
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.0227	0	0	0	0	0
GO:0004474	malate synthase activity	molecular_function	Escherichia	Escherichia coli	0.18194	0	0	0	0	0.0160078
GO:0004476	mannose-6-phosphate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	0.206414	1.43657	1.96276	1.34644	1.35921	2.50581
GO:0004476	mannose-6-phosphate isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	103.329	36.5149	39.0852	43.9878	53.5191	43.192
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	3.36373	25.4413	20.4405	67.1305	69.6195	82.2671
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.6246	15.6943	13.5065	11.7277	13.4742	12.471
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0648918	0	0	0	0	0
GO:0004478	methionine adenosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.44273	25.2447	17.4504	80.409	108.614	87.4991
GO:0004478	methionine adenosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	27.8182	10.2815	7.51373	26.666	34.968	18.8696
GO:0004478	methionine adenosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.13462	0.215492	0.0833114	0.183691	0.320661	0.298617
GO:0004479	methionyl-tRNA formyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.67234	8.05829	3.97437	21.9495	25.1216	21.5837
GO:0004479	methionyl-tRNA formyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.0495	2.86697	1.65089	4.64895	5.52834	3.92817
GO:0004479	methionyl-tRNA formyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.030453	0	0	0	0	0
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	molecular_function	Clostridium	Clostridium thermocellum	3.36373	25.4413	20.4405	67.1305	69.6195	82.2671
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.1493	7.35935	4.96675	6.47417	8.13417	6.97611
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.0648918	0	0	0	0	0
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	molecular_function	Clostridium	Clostridium thermocellum	1.57845	10.2468	7.60732	23.8811	24.2439	32.6953
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.722657	0.346785	0.335366	0.154046	0.484084	0.24044
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	molecular_function	Escherichia	Escherichia coli	0.0654265	0	0.365136	0	0	0
GO:0004492	methylmalonyl-CoA decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0764362	0	0	0	0	0
GO:0004493	methylmalonyl-CoA epimerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.3162	8.23365	8.48653	14.4089	14.1878	7.84829
GO:0004494	methylmalonyl-CoA mutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	36.169	30.2736	36.8775	35.6744	41.2843	29.5255
GO:0004494	methylmalonyl-CoA mutase activity	molecular_function	Escherichia	Escherichia coli	0.024377	0	0	0	0	0
GO:0004496	mevalonate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0638711	0	0	0.0326296	0.0569702	0
GO:0004497	monooxygenase activity	molecular_function	Escherichia	Escherichia coli	0.0551702	0	0	0	0	0
GO:0004512	inositol-3-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.152362	0.292504	0.471046	1.14353	0.702936	2.02296
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular_function	Clostridium	Clostridium thermocellum	2.85405	9.54247	7.30985	28.0832	25.783	21.5468
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	89.3657	60.1381	85.4022	59.323	66.2923	35.4696
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular_function	Escherichia	Escherichia coli	0.111507	0	0	0	0	0.0614116
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.140891	0.270474	1.04566	0.79286	0.597525	1.31196
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.34085	20.9829	21.6321	36.9281	37.2437	53.7562
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.82436	1.08143	1.04268	1.66978	1.50679	0.969682
GO:0004516	nicotinate phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.5758	3.20363	4.54108	9.51954	9.20165	8.45937
GO:0004516	nicotinate phosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0461534	0	0	0	0	0.0614116
GO:0004518	nuclease activity	molecular_function	Clostridium	Clostridium thermocellum	21.0796	51.9369	34.9582	173.701	134.793	129.926
GO:0004518	nuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	55.8066	40.5733	20.8201	50.4157	46.4035	50.3637
GO:0004518	nuclease activity	molecular_function	Escherichia	Escherichia coli	0.098796	0	0	0	0	0.131458
GO:0004518	nuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.387917	0.820709	0.32427	0.874657	0.261824	0.506459
GO:0004519	endonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	17.8288	128.05	87.0348	232.783	205.035	246.972
GO:0004519	endonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.5659	32.7569	26.7187	28.7994	36.2562	27.7007
GO:0004519	endonuclease activity	molecular_function	Escherichia	Escherichia coli	14.215	0	19.0134	0	0	14.9181
GO:0004519	endonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.507712	4.05309	2.5444	1.32391	1.07866	1.98554
GO:0004520	endodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.117413	0	0	0	0	0
GO:0004521	endoribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	32.7334	113.255	88.1507	348.974	329.816	293.132
GO:0004521	endoribonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.6697	20.4772	24.8957	11.9362	18.021	18.0653
GO:0004521	endoribonuclease activity	molecular_function	Escherichia	Escherichia coli	1.1593	0	0.234914	0	0	0.336874
GO:0004521	endoribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.385778	0.370448	0.358009	0	0.694624	0
GO:0004523	RNA-DNA hybrid ribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	6.60254	42.4215	39.2954	125.812	115.846	91.043
GO:0004523	RNA-DNA hybrid ribonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.3696	16.8787	7.154	15.0504	17.1981	11.483
GO:0004523	RNA-DNA hybrid ribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.108736	0	0	0	0	0
GO:0004523	RNA-DNA hybrid ribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.102879	0.197149	0.286516	0.686316	0.23029	0.411803
GO:0004525	ribonuclease III activity	molecular_function	Clostridium	Clostridium thermocellum	4.14681	40.0227	24.6458	88.8496	77.3832	115.279
GO:0004526	ribonuclease P activity	molecular_function	Clostridium	Clostridium thermocellum	7.86346	63.3051	50.074	182.415	160.09	200.806
GO:0004526	ribonuclease P activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.77181	3.4195	3.27675	5.62935	1.25308	8.58045
GO:0004527	exonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	0.786552	4.32842	5.81313	17.9185	10.1795	12.5853
GO:0004527	exonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.5885	34.9914	35.9408	31.3281	39.4867	21.3861
GO:0004527	exonuclease activity	molecular_function	Escherichia	Escherichia coli	0.0798631	0	0.0179072	0	0	0.0256771
GO:0004527	exonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.40476	1.41314	0.770146	1.8231	0.971466	5.41185
GO:0004530	deoxyribonuclease I activity	molecular_function	Escherichia	Escherichia coli	0.0871057	0	0	0	0	0.0579513
GO:0004534	5'-3' exoribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	0.768105	10.3592	7.48738	30.4662	30.5283	29.2001
GO:0004534	5'-3' exoribonuclease activity	molecular_function	Escherichia	Escherichia coli	0	0	0.116555	0	0	0.0883498
GO:0004540	ribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	3.60021	22.6071	16.4999	76.4092	73.2016	75.4608
GO:0004540	ribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.109563	0	0	0	0	0.0979868
GO:0004540	ribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0	0.1767
GO:0004549	tRNA-specific ribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	3.09874	22.0906	19.5707	49.8565	44.7456	41.7264
GO:0004549	tRNA-specific ribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.171465	0	0	0	0	0
GO:0004550	nucleoside diphosphate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.86167	12.8491	11.2268	58.815	46.6577	64.3269
GO:0004550	nucleoside diphosphate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	161.758	282.441	228.356	175.603	195.079	248.125
GO:0004550	nucleoside diphosphate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.396861	0.152529	0.883498	0.485838	0.638087	0.949793
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	Clostridium	Clostridium thermocellum	243.578	426.5	408.561	1146.64	1087.85	1158.79
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.3339	38.3753	20.3505	25.8515	35.8054	29.1819
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	Escherichia	Escherichia coli	1.51076	0	2.38798	0	0	0.0514188
GO:0004555	alpha,alpha-trehalase activity	molecular_function	Escherichia	Escherichia coli	0.0972162	0	0.222825	0	0	0
GO:0004556	alpha-amylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	101.997	40.8794	52.5729	38.4827	41.8009	33.3908
GO:0004556	alpha-amylase activity	molecular_function	Escherichia	Escherichia coli	0.104191	0	0.0487149	0	0	0
GO:0004557	alpha-galactosidase activity	molecular_function	Escherichia	Escherichia coli	0.0402961	0	0	0	0	0
GO:0004558	alpha-1,4-glucosidase activity	molecular_function	Escherichia	Escherichia coli	0.016867	0	0	0	0	0
GO:0004559	alpha-mannosidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0327593
GO:0004563	beta-N-acetylhexosaminidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.287104	1.96897	0.493599	4.28	4.08377	5.26529
GO:0004563	beta-N-acetylhexosaminidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.15682	0.18156	0	0.0484221	0.16874	0
GO:0004563	beta-N-acetylhexosaminidase activity	molecular_function	Escherichia	Escherichia coli	0.0554862	0	0	0	0	0
GO:0004565	beta-galactosidase activity	molecular_function	Escherichia	Escherichia coli	2179.04	0	768.067	0	0	225.731
GO:0004568	chitinase activity	molecular_function	Clostridium	Clostridium thermocellum	5.29947	8.80582	9.09723	23.3712	19.9315	20.0054
GO:0004576	oligosaccharyl transferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.228774	0.391592	0.231305	0.153225	0.327671	0.202312
GO:0004585	ornithine carbamoyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.50707	2.58642	1.39825	7.4204	5.77356	4.76255
GO:0004585	ornithine carbamoyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	51.7953	16.3761	20.4556	20.6356	23.7289	14.788
GO:0004585	ornithine carbamoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.05675	0	0.0494366	0	0	0
GO:0004585	ornithine carbamoyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.28934	0.24695	0.715838	0.19739399999999999	0.258373	0.598884
GO:0004586	ornithine decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0726691	0	0.0220119	0	0	0
GO:0004588	orotate phosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.1579	4.68626	2.36768	1.02219	2.77335	2.067
GO:0004588	orotate phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.41646	2.8497	2.17534	1.8344	1.60022	1.31639
GO:0004589	orotate reductase (NADH) activity	molecular_function	Clostridium	Clostridium thermocellum	0.785021	5.36028	4.36413	21.353	15.7481	14.4096
GO:0004589	orotate reductase (NADH) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159386	0.122518	0.118404	0.195778	0.113897	0.0848896
GO:0004590	orotidine-5'-phosphate decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.427873	3.69296	2.61121	7.47407	12.7419	11.5439
GO:0004590	orotidine-5'-phosphate decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.65496	0.502161	1.29126	0.534832	0.505483	0.811253
GO:0004590	orotidine-5'-phosphate decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.226417	0.346785	0.0842136	0.835562	0.283353	0.512798
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	molecular_function	Escherichia	Escherichia coli	0.00916263	0	0	0	0	0
GO:0004592	pantoate-beta-alanine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	4.14834	22.4429	12.4929	47.0788	46.2156	50.0343
GO:0004592	pantoate-beta-alanine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	28.1785	13.5293	17.686	16.3655	18.0141	13.8987
GO:0004592	pantoate-beta-alanine ligase activity	molecular_function	Escherichia	Escherichia coli	0.0692422	0	0	0	0	0
GO:0004594	pantothenate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	14.6644	93.1317	77.7649	208.36	193.382	177.128
GO:0004594	pantothenate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.5659	13.794	9.32691	14.7015	16.0576	10.3332
GO:0004594	pantothenate kinase activity	molecular_function	Escherichia	Escherichia coli	0.125117	0	0	0	0	0
GO:0004595	pantetheine-phosphate adenylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.35608	26.1485	22.2304	65.138	64.5237	83.1103
GO:0004595	pantetheine-phosphate adenylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.4902	56.2534	48.499	34.4354	37.4669	34.461
GO:0004595	pantetheine-phosphate adenylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.681377	0	0	0
GO:0004595	pantetheine-phosphate adenylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.127512	0.246461	0.407348	0.0592924	0.264823
GO:0004596	peptide alpha-N-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0736413	0	0.135454	0	0	0
GO:0004601	peroxidase activity	molecular_function	Clostridium	Clostridium thermocellum	22.6348	216.426	161.484	605.149	432.637	705.98
GO:0004601	peroxidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	260.486	574.494	494.362	378.685	526.602	516.122
GO:0004601	peroxidase activity	molecular_function	Escherichia	Escherichia coli	0.313036	0	0.211143	0	0	0
GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	molecular_function	Clostridium	Clostridium thermocellum	0.170566	28.8948	17.7178	62.1958	54.7957	58.7528
GO:0004605	phosphatidate cytidylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	38.6834	30.7983	30.6151	37.2582	38.9489	27.505
GO:0004605	phosphatidate cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.323463	0	0	0	0	0
GO:0004609	phosphatidylserine decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0296752	0	0	0	0	0
GO:0004609	phosphatidylserine decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.35766	0.172802	0.19058	0.415611	0.803427
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	189.884	47.5127	106.482	7.40456	7.98654	10.4351
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	molecular_function	Escherichia	Escherichia coli	0.0745648	0	0	0	0	0.0216994
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	molecular_function	Clostridium	Clostridium thermocellum	3.81639	65.064	74.5875	230.114	193.526	182.721
GO:0004614	phosphoglucomutase activity	molecular_function	Clostridium	Clostridium thermocellum	4.60829	38.8424	31.8566	98.9275	100.38	84.5695
GO:0004615	phosphomannomutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.8829	23.3093	38.9594	16.8403	20.9545	17.0455
GO:0004615	phosphomannomutase activity	molecular_function	Escherichia	Escherichia coli	0.03981	0	0	0	0	0
GO:0004615	phosphomannomutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.219466	0.306412	0.222149	0.38785	0.213665	0.132719
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	molecular_function	Escherichia	Escherichia coli	0.128496	0	0.118855	0	0	0
GO:0004617	phosphoglycerate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0224326	0	0	0	0	0
GO:0004617	phosphoglycerate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.03405	0.326855	0.126027	0.191276	0.334051	0.724488
GO:0004618	phosphoglycerate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	3.79131	58.1847	51.2642	168.02	174.865	180.172
GO:0004618	phosphoglycerate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	111.779	217.204	256.907	182.841	228.413	77.4405
GO:0004618	phosphoglycerate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0239638	0	0	0	0	0
GO:0004618	phosphoglycerate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.604126	0.472757	0.498245	0.847126	0.139897	0.387129
GO:0004619	phosphoglycerate mutase activity	molecular_function	Escherichia	Escherichia coli	0.0757071	0	0	0	0	0
GO:0004622	lysophospholipase activity	molecular_function	Escherichia	Escherichia coli	0.0556806	0	0	0	0	0
GO:0004632	phosphopantothenate--cysteine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.40399	14.0103	9.51189	35.0685	35.422	28.2307
GO:0004632	phosphopantothenate--cysteine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.75624	4.16977	2.89714	3.77369	4.86838	3.58089
GO:0004632	phosphopantothenate--cysteine ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.144245	0.461509	0.356881	0.318537	0.0643926	0.383798
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	2.40399	14.0103	9.51189	35.0685	35.422	28.2307
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.75624	4.16977	2.89714	3.77369	4.86838	3.58089
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.144245	0.461509	0.356881	0.318537	0.0643926	0.383798
GO:0004634	phosphopyruvate hydratase activity	molecular_function	Clostridium	Clostridium thermocellum	3.85773	22.1513	21.5629	82.9536	74.2882	59.5495
GO:0004634	phosphopyruvate hydratase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	45.8416	44.4224	44.6618	63.8743	66.3513	33.0344
GO:0004634	phosphopyruvate hydratase activity	molecular_function	Escherichia	Escherichia coli	0.0423134	0	0	0	0	0
GO:0004634	phosphopyruvate hydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0882966	0.0847593	0.245785	0.20289	0.137987	0.117487
GO:0004635	phosphoribosyl-AMP cyclohydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	5.16145	12.643	7.12207	41.9038	37.3034	32.0724
GO:0004635	phosphoribosyl-AMP cyclohydrolase activity	molecular_function	Escherichia	Escherichia coli	0.105553	0	0	0	0	0
GO:0004635	phosphoribosyl-AMP cyclohydrolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.523771	0	0.744487	0.402264	0.484469
GO:0004636	phosphoribosyl-ATP diphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	5.16145	12.643	7.12207	41.9038	37.3034	32.0724
GO:0004636	phosphoribosyl-ATP diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.105553	0	0	0	0	0
GO:0004636	phosphoribosyl-ATP diphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.344729	0	0	0.176379	0	0
GO:0004637	phosphoribosylamine-glycine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.01403	3.10991	2.39668	42.2397	25.3504	20.3035
GO:0004637	phosphoribosylamine-glycine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.218907	0.0841058	0.325081	0.156781	0.136663	0.116549
GO:0004637	phosphoribosylamine-glycine ligase activity	molecular_function	Escherichia	Escherichia coli	0.149227	0	0	0	0	0
GO:0004637	phosphoribosylamine-glycine ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0992578	0.190708	0.662883	0.446991	0.265904	0.554806
GO:0004638	phosphoribosylaminoimidazole carboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0529585	0	0.0982867	0	0	0
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	molecular_function	Clostridium	Clostridium thermocellum	5.4872	26.5875	18.6503	57.3266	73.4186	83.0339
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.8198	8.56666	8.91942	10.4106	14.3067	6.56819
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	molecular_function	Escherichia	Escherichia coli	0.0430911	0	0	0	0	0
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.312713	0	0.0832403	0.0727048	0
GO:0004640	phosphoribosylanthranilate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	18.6339	91.8732	205.184	213.941	99.8994	113.607
GO:0004640	phosphoribosylanthranilate isomerase activity	molecular_function	Escherichia	Escherichia coli	0.0401989	0	0.403341	0	0	0
GO:0004640	phosphoribosylanthranilate isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.337267	0	0	0.215898	0	0.449058
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	molecular_function	Clostridium	Clostridium thermocellum	3.17338	8.07094	4.4925	73.8931	64.9073	47.4268
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.168184	0	0	0.114751	0	0.149147
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	molecular_function	Escherichia	Escherichia coli	0.0273664	0	0	0	0	0
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.0538147	0	0.172101	0	0.223785
GO:0004642	phosphoribosylformylglycinamidine synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	40.0243	24.5918	29.3687	38.3741	50.1104	39.1429
GO:0004642	phosphoribosylformylglycinamidine synthase activity	molecular_function	Escherichia	Escherichia coli	0.00651349	0	0	0	0	0
GO:0004642	phosphoribosylformylglycinamidine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.436088	2.51687	2.98446	0.386432	0.335809	0.664144
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.53247	2.87719	2.16578	36.1461	27.8234	16.8718
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0520107	0	0	0	0	0
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0337826	0	0	0	0	0
GO:0004644	phosphoribosylglycinamide formyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.68215	4.85765	2.25058	51.3108	40.3012	35.0655
GO:0004644	phosphoribosylglycinamide formyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.26297	0	0	0.124181
GO:0004645	phosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.738284	1.98489	2.77977	9.99093	9.33907	7.15631
GO:0004645	phosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	30.5868	22.757	25.5162	24.0789	31.9322	18.0353
GO:0004645	phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0414384	0	0	0	0	0
GO:0004647	phosphoserine phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.11015	0	0	0.114674
GO:0004647	phosphoserine phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.145095	0.348792	0.269691	0.260216	0.388699	0.338362
GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.83627	38.8084	29.9703	82.1011	81.3638	64.717
GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0959863	0	0	0
GO:0004652	polynucleotide adenylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0742451	0	0	0
GO:0004654	polyribonucleotide nucleotidyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.72492	16.2016	15.1478	61.5467	63.3508	61.82
GO:0004654	polyribonucleotide nucleotidyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.5488	53.4827	41.7801	34.7674	39.6371	35.03
GO:0004655	porphobilinogen synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.116975	17.2936	10.5792	18.964	18.7113	28.8204
GO:0004655	porphobilinogen synthase activity	molecular_function	Escherichia	Escherichia coli	0.0294565	0	0.109338	0	0	0
GO:0004655	porphobilinogen synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.434058	0	0.0522389	0.311359
GO:0004657	proline dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.00636766	0	0	0	0	0
GO:0004658	propionyl-CoA carboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.7308	24.1489	20.9167	25.6852	28.76	20.2805
GO:0004659	prenyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.82448	14.6845	12.1855	34.2103	30.4807	42.2707
GO:0004659	prenyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	55.5829	45.2354	39.5043	26.6307	28.8053	32.1429
GO:0004659	prenyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.507663	0.578939	0.791662	0.65687	0.990868	0.760384
GO:0004664	prephenate dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	1.98005	18.4487	13.3233	48.5815	38.0421	46.1078
GO:0004664	prephenate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0721101	0	0	0	0	0
GO:0004664	prephenate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0861822	0	0	0.176379	0	0
GO:0004665	prephenate dehydrogenase (NADP+) activity	molecular_function	Clostridium	Clostridium thermocellum	3.38371	16.3874	12.5114	61.2005	62.8299	58.0045
GO:0004665	prephenate dehydrogenase (NADP+) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.2427	0.544541	0.41349	0.496905	0.289343	0.565963
GO:0004672	protein kinase activity	molecular_function	Clostridium	Clostridium thermocellum	7.45145	125.108	181.324	120.968	133.784	130.793
GO:0004672	protein kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	75.0917	139.048	107.562	77.1771	113.396	139.174
GO:0004672	protein kinase activity	molecular_function	Escherichia	Escherichia coli	0.251012	0	0.111052	0	0	0
GO:0004672	protein kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.174041	0.243076	0	0.0485714	0.0282572	0.294187
GO:0004673	protein histidine kinase activity	molecular_function	Clostridium	Clostridium thermocellum	6.39588	71.5724	51.717	237.038	215.67	195.354
GO:0004673	protein histidine kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.7059	37.7065	30.1439	26.8137	59.6813	43.0816
GO:0004673	protein histidine kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.287237	0	0	0.103032
GO:0004674	protein serine/threonine kinase activity	molecular_function	Clostridium	Clostridium thermocellum	6.96112	35.6461	30.2686	102.969	97.4742	102.245
GO:0004674	protein serine/threonine kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.3533	25.4559	20.4179	24.5232	34.2803	29.4076
GO:0004674	protein serine/threonine kinase activity	molecular_function	Escherichia	Escherichia coli	0.356686	0	0.056834	0	0	0.0409087
GO:0004674	protein serine/threonine kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.595862	0.470283	0.297116	0.691986	0.566707	0.558299
GO:0004683	calmodulin-dependent protein kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0556077	0	0	0	0	0.0246746
GO:0004712	protein serine/threonine/tyrosine kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.116927	0.192435	0.0620212	0.136711	0.178984	0.0888996
GO:0004713	protein tyrosine kinase activity	molecular_function	Escherichia	Escherichia coli	0.0241339	0	0.0892204	0	0	0
GO:0004715	non-membrane spanning protein tyrosine kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0810054	0.0778049	0.150339	0.41451	0.434058	1.2931
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.150126	0	0	0	0	0
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0482192	0	0.714034	0.19739399999999999	0.0430586	0
GO:0004721	phosphoprotein phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	25.0964	43.7269	34.3691	34.0487	43.6273	31.819
GO:0004721	phosphoprotein phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.472714	0	0.234779	0	0	0.0409087
GO:0004722	protein serine/threonine phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	4.93647	29.9201	30.9732	87.7261	84.643	86.1459
GO:0004722	protein serine/threonine phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.3109	17.9195	22.4086	8.36427	10.611	10.9722
GO:0004725	protein tyrosine phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	19.3853	70.367	65.5947	78.3262	101.396	112.694
GO:0004725	protein tyrosine phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0208286	0	0	0	0	0
GO:0004725	protein tyrosine phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.399656	0	0	0	0	0.266149
GO:0004730	pseudouridylate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.07992	3.38192	3.26796	1.73579	2.60042	1.87404
GO:0004730	pseudouridylate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0004731	purine-nucleoside phosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	1.72022	18.1692	10.3778	43.6338	44.313	48.9259
GO:0004731	purine-nucleoside phosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	28.585	20.7275	25.3295	20.3184	29.3266	23.5188
GO:0004731	purine-nucleoside phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0852829	0	0	0	0	0
GO:0004733	pyridoxamine-phosphate oxidase activity	molecular_function	Clostridium	Clostridium thermocellum	5.39805	60.7914	55.4234	115.168	118.371	180.87
GO:0004733	pyridoxamine-phosphate oxidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.502021	0.371225	0.753639	1.08491	1.39115
GO:0004735	pyrroline-5-carboxylate reductase activity	molecular_function	Clostridium	Clostridium thermocellum	2.59103	20.7372	19.3588	49.6324	43.152	37.7646
GO:0004735	pyrroline-5-carboxylate reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0397128	0	0.147272	0.162477	0.0709251	0.158525
GO:0004736	pyruvate carboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.75758	6.23732	5.74456	5.50612	6.79375	4.79741
GO:0004736	pyruvate carboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.214483	0.324848	0.387915	0.422295	0.22851	0.521044
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.98204	0	0	0.176379	0.10259	0
GO:0004743	pyruvate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	82.4715	172.006	221.728	91.3702	114.013	90.918
GO:0004746	riboflavin synthase activity	molecular_function	Clostridium	Clostridium thermocellum	1.34139	12.9787	6.66893	25.5426	23.7845	18.0357
GO:0004746	riboflavin synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.448767	0.289132	0.637695	0.277797	0.829201
GO:0004747	ribokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.484137	1.66564	2.81522	0.0990826	0.4323	1.37424
GO:0004747	ribokinase activity	molecular_function	Escherichia	Escherichia coli	0.276264	0	0	0	0	0.0783571
GO:0004747	ribokinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.10464	0.913123	0.976913	1.40999	0.602386	1.25934
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	Clostridium	Clostridium thermocellum	4.8596	35.6615	27.4644	44.2686	37.3282	32.9128
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	43.4601	12.68	12.8797	12.3158	13.8459	8.77247
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	Escherichia	Escherichia coli	0.17861	0	0.200498	0	0	0.0329857
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0743218	0	0.137935	0	0.055299	0.0494138
GO:0004749	ribose phosphate diphosphokinase activity	molecular_function	Clostridium	Clostridium thermocellum	7.68042	47.456	38.0977	129.847	130.084	128.96
GO:0004749	ribose phosphate diphosphokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.0708	16.0209	9.62597	23.7424	27.9475	19.6547
GO:0004749	ribose phosphate diphosphokinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0685617	0.395372	0.191116	0.56194	0.0306445	0.548177
GO:0004750	ribulose-phosphate 3-epimerase activity	molecular_function	Clostridium	Clostridium thermocellum	1.37374	14.2688	7.56172	54.0517	42.5857	66.3568
GO:0004750	ribulose-phosphate 3-epimerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.83739	2.90795	0.790128	2.32528	3.97537	4.41161
GO:0004750	ribulose-phosphate 3-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.180992	0	0.0933701	0	0	0.1225
GO:0004751	ribose-5-phosphate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	22.6719	98.7472	96.9038	224.296	228.218	292.399
GO:0004751	ribose-5-phosphate isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	26.7488	25.4178	26.6931	25.5749	29.1205	24.0404
GO:0004751	ribose-5-phosphate isomerase activity	molecular_function	Escherichia	Escherichia coli	0.0953205	0	0.300724	0	0	0
GO:0004751	ribose-5-phosphate isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.366068	1.3183	1.01918	1.49649	0.69458	0.912054
GO:0004756	selenide, water dikinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.75728	11.4487	13.667	8.41754	10.591	12.1338
GO:0004760	serine-pyruvate transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	0.675045	12.1893	8.1666	8.05742	7.65503	4.29156
GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	molecular_function	Clostridium	Clostridium thermocellum	1.36543	6.36931	4.52466	37.8689	40.8847	40.2398
GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.214289	0	0	0	0	0
GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.307155	1.98349	0.569964	0.0392948	0.171431	0.306379
GO:0004765	shikimate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	7.3903	57.9144	28.3575	153.827	70.6191	273.484
GO:0004765	shikimate kinase activity	molecular_function	Escherichia	Escherichia coli	0.130659	0	0	0	0	0
GO:0004765	shikimate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0337583	0.453761	0.563829	0.379866	0.18085	0.494074
GO:0004766	spermidine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	2.75926	18.0253	17.4834	48.3895	53.496	53.4748
GO:0004766	spermidine synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	97.7919	83.4617	86.3589	70.7699	87.7041	54.3586
GO:0004766	spermidine synthase activity	molecular_function	Escherichia	Escherichia coli	0.067784	0	0.125711	0	0	0.0451128
GO:0004775	succinate-CoA ligase (ADP-forming) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.235458	0.0984813	0.0935055	0.094208	0.210171	0.0682351
GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.0781861	0	0	0	0	0
GO:0004781	sulfate adenylyltransferase (ATP) activity	molecular_function	Escherichia	Escherichia coli	0.178149	0	0	0	0	0
GO:0004783	sulfite reductase (NADPH) activity	molecular_function	Escherichia	Escherichia coli	0.119503	0	0	0	0	0
GO:0004784	superoxide dismutase activity	molecular_function	Clostridium	Clostridium thermocellum	0	0.178807	0	0	0.457259	0.12389
GO:0004784	superoxide dismutase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.242492	0	0	0
GO:0004784	superoxide dismutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	4.87415	1.09744	1.63826	1.06317	0.695709	0.552348
GO:0004788	thiamine diphosphokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.52963	3.21931	2.74946	2.52561	2.69027	2.35556
GO:0004788	thiamine diphosphokinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265619	0.339924	0.32851	0	0.11852	0.1767
GO:0004789	thiamine-phosphate diphosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.131947	2.4821	6.56239	1.72748	2.12055	2.28183
GO:0004789	thiamine-phosphate diphosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.149932	0.0960543	0.185071	0	0	0.26602
GO:0004789	thiamine-phosphate diphosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.100108	0	0	0	0	0
GO:0004789	thiamine-phosphate diphosphorylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.17251	0.551682	0	0.527918	0.205114	0.153254
GO:0004791	thioredoxin-disulfide reductase activity	molecular_function	Clostridium	Clostridium thermocellum	3.34271	26.5836	22.3044	73.621	51.4425	40.9378
GO:0004791	thioredoxin-disulfide reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	60.5844	45.6812	40.6282	27.2136	35.3746	29.7026
GO:0004791	thioredoxin-disulfide reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.127572	1.10196	0.532751	0.456765	0.427222	0.424383
GO:0004792	thiosulfate sulfurtransferase activity	molecular_function	Escherichia	Escherichia coli	0.421918	0	0	0	0	0.173886
GO:0004792	thiosulfate sulfurtransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.02534	2.16575	0	0	0	0
GO:0004794	L-threonine ammonia-lyase activity	molecular_function	Escherichia	Escherichia coli	0.231423	0	0.0536766	0	0	0
GO:0004795	threonine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	9.68106	58.6653	53.2288	130.536	125.436	141.594
GO:0004795	threonine synthase activity	molecular_function	Escherichia	Escherichia coli	0.0427508	0	0	0	0	0
GO:0004795	threonine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0907756	1.35027	0.631624	0.83581	0.648331	0.783345
GO:0004797	thymidine kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.8045	14.4913	14.601	13.952	18.8738	12.0016
GO:0004798	thymidylate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.85979	4.36492	5.40031	19.7196	19.5344	17.4885
GO:0004798	thymidylate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.01618	3.2385	4.17365	3.22284	2.45792	2.24471
GO:0004798	thymidylate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0986988	0	0	0	0	0
GO:0004798	thymidylate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.055875	0.42893	0.93298	0.457386	0.149685	1.03847
GO:0004799	thymidylate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	4.20754	24.2485	18.8704	62.4472	63.5952	70.4747
GO:0004799	thymidylate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.364099	1.92305	0.844391	0.372753	0.650436	0.54504
GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	135.437	314.936	341.745	128.573	149.254	152.303
GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	molecular_function	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0004802	transketolase activity	molecular_function	Escherichia	Escherichia coli	0.0263942	0	0	0	0	0
GO:0004803	transposase activity	molecular_function	Clostridium	Clostridium thermocellum	50.6674	207.17	179.61	328.57	308.305	326.202
GO:0004803	transposase activity	molecular_function	Escherichia	Escherichia coli	7.92575	0	2.48347	0	0	0.887541
GO:0004805	trehalose-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.159945	0	0	0	0	0
GO:0004805	trehalose-phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.217079	0.139198	0.0770476	0.0672356	0
GO:0004807	triose-phosphate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	7.97827	104.076	77.7508	385.024	369.989	319.97
GO:0004807	triose-phosphate isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	69.0326	107.358	122.921	115.124	93.868	41.6785
GO:0004807	triose-phosphate isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.179947	0.688949	0	0.0920195	0.281335	0.359091
GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0261755	0	0	0	0	0
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.129638	0	1.08255	0.150216	0.181545	0.215377
GO:0004810	tRNA adenylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.60429	7.88873	6.48377	27.1068	28.7997	21.395
GO:0004810	tRNA adenylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.83085	2.93031	0.514844	1.9865	2.52672	1.4395
GO:0004810	tRNA adenylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.122249	0.356213	0.552237	0.224105	0.257071	0.766173
GO:0004812	aminoacyl-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	5.3624	18.1744	10.1945	34.178	28.4465	43.0052
GO:0004812	aminoacyl-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.43158	29.0199	18.8658	23.913	24.1686	9.43613
GO:0004812	aminoacyl-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.346163	0.238035	0.167751	0.112264	0.131476	0.194066
GO:0004813	alanine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	5.49719	19.1865	11.5244	63.4788	64.6384	64.436
GO:0004813	alanine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	33.666	44.1163	47.612	43.4753	62.2984	46.8456
GO:0004813	alanine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0195891	0	0	0	0	0
GO:0004814	arginine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	14.0925	38.9658	49.3593	83.7525	86.937	71.8438
GO:0004814	arginine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	41.754	41.1333	32.755	51.7953	57.2362	34.3873
GO:0004814	arginine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.076655	0	0	0	0	0
GO:0004814	arginine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0792798	1.03517	0.646194	0.259569	0.184019	0.0843722
GO:0004815	aspartate-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.0965	18.8049	20.9213	20.1682	21.0927	17.8676
GO:0004815	aspartate-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0299426	0	0	0	0	0
GO:0004815	aspartate-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0417544	0.0801853	0.154985	0.213386	0.0372856	0.138863
GO:0004816	asparagine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.34199	16.3389	11.4461	45.0052	43.2546	38.7695
GO:0004816	asparagine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.2449	20.8917	17.6842	13.8413	16.2779	15.6655
GO:0004816	asparagine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0950045	0	0	0	0	0
GO:0004817	cysteine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.56572	12.2106	8.96696	28.6586	23.4713	15.921
GO:0004817	cysteine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.6957	7.68243	4.86418	7.07781	9.52005	7.78834
GO:0004817	cysteine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.039324	0	0.036491	0	0	0.0523243
GO:0004818	glutamate-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	4.28541	13.4853	13.6406	42.5905	41.3559	33.4363
GO:0004818	glutamate-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.1668	7.405	5.89757	6.48456	9.30782	6.88159
GO:0004818	glutamate-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0384004	0	0	0	0	0
GO:0004818	glutamate-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0321543	0.308746	0.0596757	0	0.0574259	0
GO:0004819	glutamine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.33414	19.5644	13.4457	57.1243	62.2455	49.6799
GO:0004820	glycine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	4.03843	22.7861	16.3044	71.33	61.2833	62.8522
GO:0004820	glycine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.6999	6.40707	6.34443	9.92818	11.3027	9.74119
GO:0004820	glycine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.334229	0	0	0	0	0
GO:0004820	glycine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.0904535	0.349394	0.176727	0.0701004	0.0835637
GO:0004821	histidine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.63978	11.8759	8.04715	27.4492	23.7777	26.3258
GO:0004821	histidine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.6129	19.4776	14.613	22.3125	23.2156	14.0687
GO:0004821	histidine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0432126	0	0	0	0	0.0287493
GO:0004821	histidine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.307325	0.866309	0.228328	0.209879	0.256377	0.327464
GO:0004822	isoleucine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	55.1984	36.1391	27.3652	30.631	32.1575	26.0457
GO:0004822	isoleucine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.00911402	0	0.0338298	0	0	0
GO:0004822	isoleucine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0977023	0.156263	0.120885	0.13308	0.0581638	0.173336
GO:0004823	leucine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	5.48015	36.422	27.236	91.0435	87.979	79.0557
GO:0004823	leucine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.2374	12.0659	12.6704	13.3937	15.282	10.5045
GO:0004823	leucine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0199779	0	0	0	0	0.0265826
GO:0004823	leucine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.209841	0.140161	0.237034	0.140044	0.105889	0.169909
GO:0004824	lysine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.45601	14.2331	9.50287	38.4728	37.9494	40.2274
GO:0004824	lysine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	37.675	31.0372	19.2826	53.2743	51.8031	42.9871
GO:0004824	lysine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.112236	0	0.0659455	0	0	0.046471
GO:0004824	lysine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0981884	0.125739	0.121517	0.100475	0.0292338	0
GO:0004825	methionine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.43692	9.97597	6.73366	33.4126	30.0803	23.122
GO:0004825	methionine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	24.9197	13.0987	14.9571	14.1977	14.6997	10.6684
GO:0004825	methionine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0386921	0	0	0	0	0
GO:0004825	methionine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.103382	0.049932699999999997	0.275362	0.120169	0.143261
GO:0004826	phenylalanine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.97312	28.3832	22.7411	42.6145	37.7424	32.7753
GO:0004826	phenylalanine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	42.5364	32.6279	31.8027	38.7024	45.6252	27.2614
GO:0004826	phenylalanine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0434313	0	0.0540825	0	0	0
GO:0004826	phenylalanine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.153869	0.502441	0.12517	0.486012	0.204919	0.40194
GO:0004827	proline-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.52422	18.083	14.3411	44.9913	40.6442	43.3146
GO:0004827	proline-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.8478	24.8163	15.5358	30.7611	38.881100000000004	29.2867
GO:0004827	proline-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0309634	0	0	0	0	0
GO:0004827	proline-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0748079	0.143708	0.138837	0.228929	0.133603	0.0993774
GO:0004828	serine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.40476	16.8858	13.3064	39.3101	43.4919	37.9766
GO:0004828	serine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7.1783	5.77516	2.36222	9.40884	9.56265	9.14085
GO:0004828	serine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0212417	0	0	0	0	0
GO:0004828	serine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.139675	0.167605	0.22675	0.303739	0.15587	0.232323
GO:0004829	threonine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	4.03547	29.0893	18.9049	72.3296	67.5599	52.1923
GO:0004829	threonine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	50.5135	73.2095	59.1197	59.8116	67.3875	40.0379
GO:0004829	threonine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0499778	0	0	0
GO:0004829	threonine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.116562	0.167885	0.162248	0.208735	0.117087	0.387776
GO:0004830	tryptophan-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.31474	19.8864	9.66349	46.4333	46.0442	41.3628
GO:0004830	tryptophan-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.7707	13.9259	10.8528	20.4638	22.8987	18.5213
GO:0004830	tryptophan-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.113597	0	0	0	0	0
GO:0004830	tryptophan-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.154209	0.395045	0.28638	0.39444	0.137792	0.0684291
GO:0004831	tyrosine-tRNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	0.924769	11.7781	8.03421	31.9374	31.988	25.6617
GO:0004831	tyrosine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.46072	1.20339	1.41855	1.02027	1.26406	0.678696
GO:0004831	tyrosine-tRNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0432126	0	0	0	0	0
GO:0004831	tyrosine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0300155	0.230474	0.111368	0.0307146	0.0535845	0.239437
GO:0004832	valine-tRNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	52.0003	32.0423	38.9351	29.4323	33.8191	26.451
GO:0004832	valine-tRNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.038206	0.348559	0.0354536	0.215052	0.12796	0.127124
GO:0004834	tryptophan synthase activity	molecular_function	Clostridium	Clostridium thermocellum	13.9437	68.4342	52.2207	236.363	182.933	178.752
GO:0004834	tryptophan synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.9345	8.31616	5.76098	13.2171	16.6092	4.21343
GO:0004834	tryptophan synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.03346	0.172599	0.233876	0.889778	0.688568	1.5761
GO:0004837	tyrosine decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0258109	0.148609	0	0.369296	0.115025	0
GO:0004844	uracil DNA N-glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.315126	0	0	0	0	0
GO:0004845	uracil phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	11.8634	81.0858	76.5841	171.093	169.026	196.382
GO:0004845	uracil phosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.1412	22.9034	23.9156	12.148	11.0766	13.6792
GO:0004845	uracil phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0975079	0	0.179027	0.149818	0.130738	0
GO:0004849	uridine kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	25.3401	45.4046	25.477	28.4036	30.6211	29.9562
GO:0004850	uridine phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0792312	0	0	0	0	0.105683
GO:0004851	uroporphyrin-III C-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0182523	12.9279	7.92212	23.4066	22.693	32.3801
GO:0004851	uroporphyrin-III C-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0471013	0	0.0874161	0	0	0
GO:0004852	uroporphyrinogen-III synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0182523	12.9279	7.92212	23.4066	22.693	32.3801
GO:0004852	uroporphyrinogen-III synthase activity	molecular_function	Escherichia	Escherichia coli	0.0819776	0	0	0	0	0
GO:0004852	uroporphyrinogen-III synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0794256	0	0.221111	0	0.0354626	0
GO:0004853	uroporphyrinogen decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.42605	155.443	166.82	60.6048	59.1935	57.2473
GO:0004854	xanthine dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.048438	0	0	0	0	0.0720834
GO:0004855	xanthine oxidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0119007
GO:0004856	xylulokinase activity	molecular_function	Escherichia	Escherichia coli	0.0744919	0	0	0	0	0.0247716
GO:0004866	endopeptidase inhibitor activity	molecular_function	Escherichia	Escherichia coli	0.00556563	0	0	0	0	0
GO:0004871	signal transducer activity	molecular_function	Clostridium	Clostridium thermocellum	24.3366	80.2366	90.3996	434.331	412.727	369.316
GO:0004871	signal transducer activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	36.5893	23.1342	24.9425	20.3801	23.6085	19.4238
GO:0004871	signal transducer activity	molecular_function	Escherichia	Escherichia coli	0.0269046	0	0.049932699999999997	0	0	0.183362
GO:0004872	receptor activity	molecular_function	Escherichia	Escherichia coli	0.102053	0	0.306498	0	0	0.148791
GO:0004984	olfactory receptor activity	molecular_function	Escherichia	Escherichia coli	0.361523	0	0.379841	0	0	0.0899345
GO:0005048	signal sequence binding	molecular_function	Escherichia	Escherichia coli	0.195599	0	0	0	0	0.13909
GO:0005198	structural molecule activity	molecular_function	Clostridium	Clostridium thermocellum	30.9275	52.5408	36.4512	711.565	684.212	559.164
GO:0005198	structural molecule activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0268317	0	0	0	0	0
GO:0005198	structural molecule activity	molecular_function	Escherichia	Escherichia coli	15.2031	0	17.7881	0	0	18.552
GO:0005215	transporter activity	molecular_function	Clostridium	Clostridium thermocellum	17.2173	69.7364	58.8712	236.604	218.35	146.78
GO:0005215	transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1170.78	677.898	915.494	494.015	594.402	583.214
GO:0005215	transporter activity	molecular_function	Escherichia	Escherichia coli	4.18127	0	2.94355	0	0	1.10715
GO:0005215	transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.99944	0.986914	3.49723	2.09404	1.91734	1.21358
GO:0005216	ion channel activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	40.5509	80.209	60.3346	57.6281	71.0274	79.7315
GO:0005216	ion channel activity	molecular_function	Escherichia	Escherichia coli	0.372484	0	0.517821	0	0	0
GO:0005247	voltage-gated chloride channel activity	molecular_function	Clostridium	Clostridium thermocellum	1.39583	11.857	9.61176	15.9613	18.6339	24.4157
GO:0005247	voltage-gated chloride channel activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.19324	4.35679	2.96448	2.99088	3.06988	3.52225
GO:0005247	voltage-gated chloride channel activity	molecular_function	Escherichia	Escherichia coli	0.0379386	0	0	0	0	0
GO:0005262	calcium channel activity	molecular_function	Escherichia	Escherichia coli	0.0880536	0	0	0	0	0
GO:0005267	potassium channel activity	molecular_function	Escherichia	Escherichia coli	0.0557049	0	0	0	0	0
GO:0005304	L-valine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.26941	0	0	0	0	0
GO:0005315	inorganic phosphate transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	1.96736	3.66458	3.21293	1.37838	1.46176	2.78587
GO:0005315	inorganic phosphate transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	121.811	23.8095	18.4492	31.11	37.3002	22.008
GO:0005315	inorganic phosphate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.161598	0	0.310332	0	0	0.0718247
GO:0005315	inorganic phosphate transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.491136	0.96423	0.873439	0.606732	0.532394	0.857013
GO:0005328	neurotransmitter:sodium symporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	107.983	27.1758	41.6894	22.6594	27.5648	25.5205
GO:0005337	nucleoside transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0446465	0	0	0	0	0
GO:0005344	oxygen transporter activity	molecular_function	Escherichia	Escherichia coli	0.0466881	0	0	0	0	0
GO:0005345	purine nucleobase transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.3584	4.17556	5.65101	7.77604	5.76994	3.99521
GO:0005345	purine nucleobase transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0379872	0	0	0	0	0
GO:0005351	sugar:proton symporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	92.4241	20.5231	28.3484	18.3597	14.3406	8.53233
GO:0005351	sugar:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.439879	0	0.346778	0	0	0.255089
GO:0005354	galactose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0354596	0	0	0	0	0
GO:0005355	glucose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0756585	0	0.140506	0	0	0
GO:0005363	maltose transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	134.045	63.4878	144.991	25.642	38.6514	48.4664
GO:0005363	maltose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.116659	0	0	0	0	0
GO:0005384	manganese ion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.489095	3.44363	0.302709	9.39949	5.19327	9.04121
GO:0005384	manganese ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.233124	0	0	0	0	0
GO:0005384	manganese ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.222735	0.184213	0.106778	0.239534
GO:0005385	zinc ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.113894	0	0	0.0774516
GO:0005388	calcium-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	1.39102	2.74772	3.00625	9.27501	10.5159	12.0989
GO:0005388	calcium-transporting ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.7153	17.3383	18.1821	15.2639	15.476	11.57
GO:0005388	calcium-transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0610275	0.195702	0.264774	0.18762	0.0910003	0.162697
GO:0005415	nucleoside:sodium symporter activity	molecular_function	Escherichia	Escherichia coli	0.0461534	0	0	0	0	0
GO:0005451	monovalent cation:proton antiporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.298211	3.37077	2.55194	7.38812	7.07064	9.19162
GO:0005451	monovalent cation:proton antiporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	172.061	32.706	52.4692	40.9061	59.7672	30.9783
GO:0005506	iron ion binding	molecular_function	Clostridium	Clostridium thermocellum	153.719	2243.4	1268.9	6534.09	4641.59	8242.74
GO:0005506	iron ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5715.6	15150.5	12874.2	5720.03	6389.76	7852.8
GO:0005506	iron ion binding	molecular_function	Escherichia	Escherichia coli	1.76977	0	1.52897	0	0	0.691244
GO:0005506	iron ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.03361	19.3303	9.12389	7.69832	4.90158	10.6172
GO:0005507	copper ion binding	molecular_function	Clostridium	Clostridium thermocellum	16.9333	234.828	152.623	532.191	394.881	686.647
GO:0005507	copper ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	50.2588	66.8372	80.2765	34.749	48.1546	40.7722
GO:0005507	copper ion binding	molecular_function	Escherichia	Escherichia coli	0.413679	0	0.128824	0	0	0
GO:0005509	calcium ion binding	molecular_function	Clostridium	Clostridium thermocellum	8.36538	31.6643	27.2588	94.0011	100.804	175.611
GO:0005509	calcium ion binding	molecular_function	Escherichia	Escherichia coli	0.447705	0	0.245379	0	0	0.040844
GO:0005509	calcium ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.06843	0.511636	0.991347	1.75981	0	2.85895
GO:0005524	ATP binding	molecular_function	Clostridium	Clostridium thermocellum	668.581	4222.52	3620.11	10383.3	9584.47	9867.57
GO:0005524	ATP binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6241.98	4663.37	4935.41	3656.83	4405.54	3431.7
GO:0005524	ATP binding	molecular_function	Escherichia	Escherichia coli	15.6811	0	11.4563	0	0	4.07425
GO:0005524	ATP binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	25.0222	52.7989	52.6346	42.7274	25.8365	46.0619
GO:0005525	GTP binding	molecular_function	Clostridium	Clostridium thermocellum	123.793	759.52	591.357	2382.52	2088.79	1951.49
GO:0005525	GTP binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	716.148	568.669	518.586	553.919	664.223	544.29
GO:0005525	GTP binding	molecular_function	Escherichia	Escherichia coli	1.19423	0	0.246416	0	0	0.607486
GO:0005525	GTP binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	12.755	18.3124	15.8513	12.7497	6.82856	13.4991
GO:0005528	FK506 binding	molecular_function	Escherichia	Escherichia coli	0.103098	0	0	0	0	0
GO:0005534	galactose binding	molecular_function	Escherichia	Escherichia coli	0.120475	0	0	0	0	0
GO:0005542	folic acid binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	38.7195	12.9166	45.4751	2.07255	4.42169	4.76219
GO:0005543	phospholipid binding	molecular_function	Escherichia	Escherichia coli	0.0500177	0	0	0	0	0
GO:0005975	carbohydrate metabolic process	biological_process	Clostridium	Clostridium thermocellum	126.47	361.161	325.987	955.177	847.176	910.707
GO:0005975	carbohydrate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	672.536	603.786	700.263	437.905	496.515	409.395
GO:0005975	carbohydrate metabolic process	biological_process	Escherichia	Escherichia coli	145.99	0	66.1159	0	0	15.6679
GO:0005975	carbohydrate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.83961	4.36361	3.36209	4.37366	2.45349	3.87423
GO:0005977	glycogen metabolic process	biological_process	Escherichia	Escherichia coli	0.0251304	0	0	0	0	0
GO:0005978	glycogen biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	6.04374	39.584	28.5428	256.93	251.996	223.186
GO:0005978	glycogen biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	169.299	136.07	138.294	110.092	135.73	115.105
GO:0005978	glycogen biosynthetic process	biological_process	Escherichia	Escherichia coli	0.596932	0	0.0787106	0	0	0
GO:0005980	glycogen catabolic process	biological_process	Clostridium	Clostridium thermocellum	1.08846	8.18431	6.03654	29.6421	28.7723	30.4393
GO:0005980	glycogen catabolic process	biological_process	Escherichia	Escherichia coli	0.144317	0	0.228779	0	0	0
GO:0005985	sucrose metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.165946	0	0	0
GO:0005988	lactose metabolic process	biological_process	Clostridium	Clostridium thermocellum	9.86686	28.7165	21.6438	133.033	107.045	143.081
GO:0005988	lactose metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	125.074	105.814	111.725	74.0842	99.1241	73.0471
GO:0005991	trehalose metabolic process	biological_process	Escherichia	Escherichia coli	0.13044	0	0.0219217	0	0	0
GO:0005992	trehalose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.159945	0	0	0	0	0
GO:0005992	trehalose biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.162546	0.35626	0.139198	0.151235	0.0672356	0.0482173
GO:0005993	trehalose catabolic process	biological_process	Escherichia	Escherichia coli	0.0972162	0	0.200904	0	0	0
GO:0005995	melibiose catabolic process	biological_process	Escherichia	Escherichia coli	0.0402961	0	0	0	0	0
GO:0005996	monosaccharide metabolic process	biological_process	Clostridium	Clostridium thermocellum	8.9723	20.5811	17.6418	48.8933	48.7887	64.0767
GO:0005996	monosaccharide metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.6022	8.82271	4.81488	8.87252	10.4749	8.15105
GO:0005998	xylulose catabolic process	biological_process	Escherichia	Escherichia coli	0.0744919	0	0	0	0	0.0247716
GO:0005999	xylulose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0006000	fructose metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.33947	0	0	0
GO:0006002	fructose 6-phosphate metabolic process	biological_process	Clostridium	Clostridium thermocellum	12.712	116.88	72.6404	379.328	344.769	269.537
GO:0006002	fructose 6-phosphate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	233.381	310.772	242.865	253.449	310.629	177.948
GO:0006002	fructose 6-phosphate metabolic process	biological_process	Escherichia	Escherichia coli	0.209744	0	0.0554808	0	0	0
GO:0006004	fucose metabolic process	biological_process	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.166448
GO:0006006	glucose metabolic process	biological_process	Clostridium	Clostridium thermocellum	28.2254	362.751	253.872	1053.85	1079.39	914.434
GO:0006006	glucose metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	75.8646	274.922	211.047	183.353	266.927	188.019
GO:0006006	glucose metabolic process	biological_process	Escherichia	Escherichia coli	0.474585	0	0.298424	0	0	0.247878
GO:0006006	glucose metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.067784	0	0.251558	0.0693628	0	0.0901932
GO:0006007	glucose catabolic process	biological_process	Clostridium	Clostridium thermocellum	4.40013	74.3333	74.8652	106.757	98.0077	79.9185
GO:0006007	glucose catabolic process	biological_process	Escherichia	Escherichia coli	0.052278	0	0	0	0	0
GO:0006011	UDP-glucose metabolic process	biological_process	Clostridium	Clostridium thermocellum	3.00262	16.584	8.70638	40.1594	35.961	49.9037
GO:0006011	UDP-glucose metabolic process	biological_process	Escherichia	Escherichia coli	0.0913346	0	0	0	0	0.0869269
GO:0006011	UDP-glucose metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.411541	1.18523	1.3379	0.63185	0.398466	0.410963
GO:0006012	galactose metabolic process	biological_process	Clostridium	Clostridium thermocellum	2.6548	27.3309	23.0112	46.6437	55.0428	57.194
GO:0006012	galactose metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.59595	13.7924	5.45755	15.3531	18.278	12.0259
GO:0006012	galactose metabolic process	biological_process	Escherichia	Escherichia coli	0.0280226	0	0	0	0	0
GO:0006012	galactose metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.117413	0.11267	0.108932	0.420429	0.104868	0.546495
GO:0006013	mannose metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0327593
GO:0006014	D-ribose metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.484137	1.66564	2.81522	0.0990826	0.4323	1.37424
GO:0006014	D-ribose metabolic process	biological_process	Escherichia	Escherichia coli	0.217351	0	0	0	0	0
GO:0006014	D-ribose metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.10464	0.913123	0.976913	1.40999	0.602386	1.25934
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	8.49303	51.9047	43.1504	140.288	142.991	139.676
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.7395	26.4632	18.8907	36.513	43.2726	31.3404
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.060215
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0685617	0.395372	0.191116	0.56194	0.0306445	0.548177
GO:0006021	inositol biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.152362	0.292504	0.471046	1.14353	0.702936	2.02296
GO:0006024	glycosaminoglycan biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0682701	0.087373	0.168878	0.0465817	0	0.121109
GO:0006032	chitin catabolic process	biological_process	Clostridium	Clostridium thermocellum	5.29947	8.80582	9.09723	23.3712	19.9315	20.0054
GO:0006044	N-acetylglucosamine metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.20035	4.47483	3.62673	11.2753	13.3918	13.4697
GO:0006044	N-acetylglucosamine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	92.503	36.1405	61.5543	21.013	24.3019	21.5417
GO:0006044	N-acetylglucosamine metabolic process	biological_process	Escherichia	Escherichia coli	0.308054	0	0	0	0	0.0988923
GO:0006047	UDP-N-acetylglucosamine metabolic process	biological_process	Clostridium	Clostridium thermocellum	2.92271	22.322	22.6089	55.7991	61.8888	59.941
GO:0006047	UDP-N-acetylglucosamine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	38.8843	38.8641	37.9197	31.6798	32.5771	32.4612
GO:0006047	UDP-N-acetylglucosamine metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.16483	0	0.767079	0.359498	0.166049	0.219937
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	6.26833	35.7007	27.2547	96.8199	94.1636	84.6506
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.0894	14.1176	12.1005	34.4997	35.4584	19.8786
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.019905	0	0.0738842	0	0	0
GO:0006062	sorbitol catabolic process	biological_process	Escherichia	Escherichia coli	0.0770925	0	0	0	0	0
GO:0006064	glucuronate catabolic process	biological_process	Escherichia	Escherichia coli	0.057309	0	0.0705914	0	0	0
GO:0006065	UDP-glucuronate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.143394	0	0	0	0	0.0636106
GO:0006066	alcohol metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.658664	16.1959	9.70495	72.5495	65.9282	34.2944
GO:0006066	alcohol metabolic process	biological_process	Escherichia	Escherichia coli	0.0192731	0	0	0	0	0
GO:0006068	ethanol catabolic process	biological_process	Escherichia	Escherichia coli	0.0328591	0	0	0	0	0
GO:0006069	ethanol oxidation	biological_process	Escherichia	Escherichia coli	0	0	0.0939565	0	0	0.0336971
GO:0006071	glycerol metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	44.0015	40.5883	39.0635	39.6642	46.5421	34.0083
GO:0006071	glycerol metabolic process	biological_process	Escherichia	Escherichia coli	0.576176	0	0.232298	0	0	0.231449
GO:0006072	glycerol-3-phosphate metabolic process	biological_process	Escherichia	Escherichia coli	0.0716727	0	0.0664868	0	0	0
GO:0006080	substituted mannan metabolic process	biological_process	Clostridium	Clostridium thermocellum	41.2293	46.4253	52.9957	128.966	117.098	135.834
GO:0006081	cellular aldehyde metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.229819	2.94146	1.49279	7.42607	6.99288	7.20601
GO:0006082	organic acid metabolic process	biological_process	Clostridium	Clostridium thermocellum	4.97497	31.7717	26.5377	74.1942	75.7388	54.5204
GO:0006082	organic acid metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.0488	43.0591	49.0291	50.1978	48.3386	32.4178
GO:0006082	organic acid metabolic process	biological_process	Escherichia	Escherichia coli	0.0923068	0	0	0	0	0.0613792
GO:0006084	acetyl-CoA metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.8095	4.95529	3.92538	3.07335	3.79558	3.06634
GO:0006084	acetyl-CoA metabolic process	biological_process	Escherichia	Escherichia coli	0.201335	0	0	0	0	0.0829169
GO:0006084	acetyl-CoA metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0834844	0	0	0.294885	0.159451	0.11144
GO:0006085	acetyl-CoA biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	8.80132	57.9387	50.6598	123.994	132.039	128.484
GO:0006085	acetyl-CoA biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.0488	43.0591	49.0291	50.1978	48.3386	32.4178
GO:0006085	acetyl-CoA biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0923068	0	0	0	0	0.0613792
GO:0006089	lactate metabolic process	biological_process	Escherichia	Escherichia coli	0.0156518	0	0	0	0	0
GO:0006090	pyruvate metabolic process	biological_process	Clostridium	Clostridium thermocellum	2.59281	11.6392	13.25	49.2864	44.0848	41.199
GO:0006090	pyruvate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	53.4174	54.7495	42.6241	62.2203	69.7192	37.1381
GO:0006090	pyruvate metabolic process	biological_process	Escherichia	Escherichia coli	0.046445	0	0	0	0	0
GO:0006090	pyruvate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0510385	0.318407	0.355077	0.495985	0.273435	0.322516
GO:0006091	generation of precursor metabolites and energy	biological_process	Clostridium	Clostridium thermocellum	0.130416	31.3103	29.1451	43.3765	37.6878	33.5279
GO:0006094	gluconeogenesis	biological_process	Clostridium	Clostridium thermocellum	12.7286	181.224	162.281	648.555	592.409	530.483
GO:0006094	gluconeogenesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	314.784	592.819	453.248	357.14	413.998	305.421
GO:0006094	gluconeogenesis	biological_process	Escherichia	Escherichia coli	0.241582	0	0.0742451	0	0	0.0216994
GO:0006094	gluconeogenesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.671837	1.77439	1.25693	1.28133	1.11416	1.56608
GO:0006096	glycolytic process	biological_process	Clostridium	Clostridium thermocellum	50.7733	801.418	588.203	2284.02	2295.85	2088.11
GO:0006096	glycolytic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	418.009	1148.82	915.105	846.277	1043.22	643.776
GO:0006096	glycolytic process	biological_process	Escherichia	Escherichia coli	0.555858	0	0.0707719	0	0	0.0716306
GO:0006096	glycolytic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.24412	1.88729	1.24516	1.95952	0.947571	1.83782
GO:0006097	glyoxylate cycle	biological_process	Clostridium	Clostridium thermocellum	2.4552	47.411	32.8214	119.773	121.21	121.8
GO:0006097	glyoxylate cycle	biological_process	Escherichia	Escherichia coli	0.575107	0	0.190484	0	0	0.0569164
GO:0006098	pentose-phosphate shunt	biological_process	Clostridium	Clostridium thermocellum	32.0239	217.092	182.216	663.372	640.793	678.726
GO:0006098	pentose-phosphate shunt	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	235.056	450.62	492.149	271.598	276.218	222.433
GO:0006098	pentose-phosphate shunt	biological_process	Escherichia	Escherichia coli	0.189086	0	0.498921	0	0	0.1225
GO:0006098	pentose-phosphate shunt	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.179947	0.688949	0	0.0920195	0.281335	0.359091
GO:0006099	tricarboxylic acid cycle	biological_process	Clostridium	Clostridium thermocellum	2.4552	47.411	32.8214	119.773	121.21	121.8
GO:0006099	tricarboxylic acid cycle	biological_process	Escherichia	Escherichia coli	0.908024	0	0.124674	0	0	0.125119
GO:0006099	tricarboxylic acid cycle	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.746353	0.712379	0.391478	0.896792	0.728958	0.325071
GO:0006102	isocitrate metabolic process	biological_process	Clostridium	Clostridium thermocellum	2.4552	47.411	32.8214	119.773	121.21	121.8
GO:0006107	oxaloacetate metabolic process	biological_process	Escherichia	Escherichia coli	0.0194432	0	0	0	0	0
GO:0006107	oxaloacetate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0342444	0.262166	0	0.262877	0.15294	0.159528
GO:0006108	malate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.7036	8.48671	7.60015	8.90226	8.78091	8.77558
GO:0006108	malate metabolic process	biological_process	Escherichia	Escherichia coli	0.211032	0	0.212947	0	0	0.0835637
GO:0006108	malate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.440074	0.281489	0.162202	0.240295	0.104847	0
GO:0006109	regulation of carbohydrate metabolic process	biological_process	Clostridium	Clostridium thermocellum	48.7367	313.415	223.445	763.953	780.967	958.252
GO:0006112	energy reserve metabolic process	biological_process	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0006119	oxidative phosphorylation	biological_process	Escherichia	Escherichia coli	0	0	0.0646374	0	0	0.023187
GO:0006139	nucleobase-containing compound metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.750728	5.25428	4.94361	11.7933	12.995	14.2713
GO:0006139	nucleobase-containing compound metabolic process	biological_process	Escherichia	Escherichia coli	0.0414384	0	0	0	0	0
GO:0006139	nucleobase-containing compound metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0605657	0.0581553	0.22481	0.108459	0.0809953	0.181324
GO:0006144	purine nucleobase metabolic process	biological_process	Escherichia	Escherichia coli	0.206025	0	0	0	0	0.34166
GO:0006146	adenine catabolic process	biological_process	Escherichia	Escherichia coli	0.0149956	0	0.0278306	0	0	0
GO:0006146	adenine catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.148644	0.127232	0.24592	0.0508594	0.103349	0.308642
GO:0006163	purine nucleotide metabolic process	biological_process	Clostridium	Clostridium thermocellum	4.42378	27.4467	20.7349	59.5457	61.5965	71.5612
GO:0006163	purine nucleotide metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	39.9694	79.6803	76.3232	58.9659	71.4159	58.7156
GO:0006163	purine nucleotide metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.235117	0.564237	1.08797	0.960733	0.471539	1.87452
GO:0006164	purine nucleotide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	8.04685	56.8594	38.1559	166.347	169.664	171.35
GO:0006164	purine nucleotide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.1493	7.35935	4.96675	6.47417	8.13417	6.97611
GO:0006164	purine nucleotide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.135957	0	0	0	0	0
GO:0006166	purine ribonucleoside salvage	biological_process	Clostridium	Clostridium thermocellum	2.33922	13.577	10.8916	51.0264	39.3707	68.6689
GO:0006166	purine ribonucleoside salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	8.76042	9.12357	11.0711	12.0851	15.1185	13.2017
GO:0006166	purine ribonucleoside salvage	biological_process	Escherichia	Escherichia coli	0.174041	0	0.23311	0	0	0.381987
GO:0006166	purine ribonucleoside salvage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.634761	0.567212	0.199956	0.160884	0.09333
GO:0006168	adenine salvage	biological_process	Clostridium	Clostridium thermocellum	5.3083	25.8836	13.0491	63.7916	59.4961	59.5095
GO:0006168	adenine salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	82.9271	58.608	43.511	37.0193	45.5653	50.1944
GO:0006168	adenine salvage	biological_process	Escherichia	Escherichia coli	0	0	0.224404	0	0	0
GO:0006171	cAMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0269706
GO:0006177	GMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.92593	27.1335	16.1024	89.4446	80.4397	68.3222
GO:0006177	GMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	123.331	96.3271	85.7414	62.3909	84.3424	51.6951
GO:0006177	GMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0709435	0	0	0	0	0
GO:0006177	GMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.196766	0.684375	1.06555	1.21234	0.43191	1.26173
GO:0006183	GTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.86167	12.8491	11.2268	58.815	46.6577	64.3269
GO:0006183	GTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	161.758	282.441	228.356	175.603	195.079	248.125
GO:0006183	GTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.396861	0.152529	0.883498	0.485838	0.638087	0.949793
GO:0006189	'de novo' IMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	19.8679	63.0196	46.6489	320.659	304.833	273.568
GO:0006189	'de novo' IMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	59.7195	38.6645	42.6321	55.2302	70.886	51.3796
GO:0006189	'de novo' IMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.42379	0	0.361257	0	0	0.124181
GO:0006189	'de novo' IMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.99954	5.6462	6.32635	3.39607	1.86248	4.00336
GO:0006206	pyrimidine nucleobase metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.738284	1.98489	2.77977	9.99093	9.33907	7.15631
GO:0006206	pyrimidine nucleobase metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	30.5868	22.757	25.5162	24.0789	31.9322	18.0353
GO:0006206	pyrimidine nucleobase metabolic process	biological_process	Escherichia	Escherichia coli	0.195016	0	0.0567438	0	0	0.040844
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.23081	20.254	17.1549	59.8246	63.6541	60.5915
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.33669	2.70082	4.38438	1.31476	1.3433	1.58195
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	Escherichia	Escherichia coli	0.305259	0	0.0439787	0	0	0
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.509024	0.911256	0.374112	1.16977	0.507241	1.27461
GO:0006208	pyrimidine nucleobase catabolic process	biological_process	Escherichia	Escherichia coli	0.0786479	0	0	0	0	0
GO:0006212	uracil catabolic process	biological_process	Escherichia	Escherichia coli	0.0551702	0	0	0	0	0.0548468
GO:0006213	pyrimidine nucleoside metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.738284	1.98489	2.77977	9.99093	9.33907	7.15631
GO:0006213	pyrimidine nucleoside metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	30.5868	22.757	25.5162	24.0789	31.9322	18.0353
GO:0006220	pyrimidine nucleotide metabolic process	biological_process	Clostridium	Clostridium thermocellum	6.82242	51.3493	27.5884	104.762	118.867	125.629
GO:0006220	pyrimidine nucleotide metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0723289	0.138901	0	0.740408	0.38718	0.77083
GO:0006221	pyrimidine nucleotide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.628551	4.09094	1.61945	11.9282	7.41667	12.4429
GO:0006221	pyrimidine nucleotide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.50019	8.84372	6.63997	6.88117	9.53507	11.2686
GO:0006222	UMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.864033	0.484005	0.13365	0.257804	0.353627	0.431174
GO:0006223	uracil salvage	biological_process	Clostridium	Clostridium thermocellum	10.1241	63.2315	62.446	131.224	128.121	141.808
GO:0006223	uracil salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	14.1117	13.8508	17.5205	7.38217	5.14641	7.25436
GO:0006223	uracil salvage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0975079	0	0.179027	0.149818	0.130738	0
GO:0006226	dUMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.44795	10.3579	10.2479	25.2983	25.9347	35.8891
GO:0006226	dUMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.83	23.6456	13.4701	22.3517	31.1397	20.7496
GO:0006226	dUMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0786479	0	0	0	0	0
GO:0006226	dUMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.266421	0.308093	0	0.219603	0.191159	0
GO:0006228	UTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.86167	12.8491	11.2268	58.815	46.6577	64.3269
GO:0006228	UTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	161.758	282.441	228.356	175.603	195.079	248.125
GO:0006228	UTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.396861	0.152529	0.883498	0.485838	0.638087	0.949793
GO:0006229	dUTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.44795	10.3579	10.2479	25.2983	25.9347	35.8891
GO:0006229	dUTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.83	23.6456	13.4701	22.3517	31.1397	20.7496
GO:0006229	dUTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.107302	0	0	0.219603	0.04792	0
GO:0006231	dTMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.20754	24.2485	18.8704	62.4472	63.5952	70.4747
GO:0006231	dTMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.4181	24.5272	22.7811	26.6489	29.5605	19.1002
GO:0006231	dTMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.364099	1.92305	0.844391	0.372753	0.650436	0.54504
GO:0006233	dTDP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.85979	4.36492	5.40031	19.7196	19.5344	17.4885
GO:0006233	dTDP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.01618	3.2385	4.17365	3.22284	2.45792	2.24471
GO:0006233	dTDP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0986988	0	0	0	0	0
GO:0006233	dTDP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.055875	0.42893	0.93298	0.457386	0.149685	1.03847
GO:0006235	dTTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.85979	4.36492	5.40031	19.7196	19.5344	17.4885
GO:0006235	dTTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.01618	3.2385	4.17365	3.22284	2.45792	2.24471
GO:0006235	dTTP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0986988	0	0	0	0	0
GO:0006235	dTTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.419974	2.35198	1.77737	0.83014	0.8001	1.58351
GO:0006241	CTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.86167	12.8491	11.2268	58.815	46.6577	64.3269
GO:0006241	CTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	161.758	282.441	228.356	175.603	195.079	248.125
GO:0006241	CTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.396861	0.152529	0.883498	0.485838	0.638087	0.949793
GO:0006259	DNA metabolic process	biological_process	Escherichia	Escherichia coli	0.200484	0	0	0	0	0
GO:0006260	DNA replication	biological_process	Clostridium	Clostridium thermocellum	55.3214	303.437	224.862	981.635	824.881	824.135
GO:0006260	DNA replication	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	526.611	310.035	334.161	221.2	284.822	225.705
GO:0006260	DNA replication	biological_process	Escherichia	Escherichia coli	2.13929	0	2.35784	0	0	0.642768
GO:0006260	DNA replication	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.4003	4.194	4.14036	3.32961	2.10542	7.68398
GO:0006261	DNA-dependent DNA replication	biological_process	Clostridium	Clostridium thermocellum	7.73596	56.6698	47.0745	134.301	126.136	128.493
GO:0006261	DNA-dependent DNA replication	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	27.2593	19.3438	23.3301	16.2397	16.4988	12.3178
GO:0006261	DNA-dependent DNA replication	biological_process	Escherichia	Escherichia coli	0.0136346	0	0	0	0	0
GO:0006261	DNA-dependent DNA replication	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.254901	0.481252	0.621024	0.380786	0.114136	0.333252
GO:0006265	DNA topological change	biological_process	Clostridium	Clostridium thermocellum	14.5788	104.151	68.6428	253.86	250.345	266.925
GO:0006265	DNA topological change	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	66.7647	46.8587	46.3297	31.894	34.6157	26.2064
GO:0006265	DNA topological change	biological_process	Escherichia	Escherichia coli	0.138946	0	0.214345	0	0	0
GO:0006265	DNA topological change	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.694197	2.27184	2.63471	0.658312	0.578339	0.380984
GO:0006266	DNA ligation	biological_process	Escherichia	Escherichia coli	0.090241	0	0.33505	0	0	0
GO:0006268	DNA unwinding involved in DNA replication	biological_process	Clostridium	Clostridium thermocellum	2.09289	11.9003	8.03141	27.8359	27.3218	33.5524
GO:0006268	DNA unwinding involved in DNA replication	biological_process	Escherichia	Escherichia coli	0.107813	0	0.223006	0	0	0
GO:0006268	DNA unwinding involved in DNA replication	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.585217	2.24855	2.45496	0.509663	0.383816	0.268186
GO:0006269	DNA replication, synthesis of RNA primer	biological_process	Clostridium	Clostridium thermocellum	3.35377	23.5808	13.8349	77.6395	69.2138	68.7263
GO:0006269	DNA replication, synthesis of RNA primer	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.3331	9.32455	7.93813	13.0321	15.1196	9.34772
GO:0006269	DNA replication, synthesis of RNA primer	biological_process	Escherichia	Escherichia coli	0.387115	0	0.27339	0	0	0
GO:0006270	DNA replication initiation	biological_process	Clostridium	Clostridium thermocellum	1.62361	6.62831	5.33811	16.0679	18.1539	20.2148
GO:0006270	DNA replication initiation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.1311	22.1648	29.882	8.47126	12.8847	8.72642
GO:0006270	DNA replication initiation	biological_process	Escherichia	Escherichia coli	0.038765	0	0	0	0	0
GO:0006275	regulation of DNA replication	biological_process	Clostridium	Clostridium thermocellum	1.62361	6.62831	5.33811	16.0679	18.1539	20.2148
GO:0006275	regulation of DNA replication	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.1311	22.1648	29.882	8.47126	12.8847	8.72642
GO:0006275	regulation of DNA replication	biological_process	Escherichia	Escherichia coli	0.038765	0	0	0	0	0
GO:0006275	regulation of DNA replication	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.166118	0.159437	0.0770868	0.595043	0.519394	1.1055
GO:0006276	plasmid maintenance	biological_process	Escherichia	Escherichia coli	0.019662	0	0	0	0	0
GO:0006281	DNA repair	biological_process	Clostridium	Clostridium thermocellum	45.906	298.9	234.96	710.443	689.692	777.07
GO:0006281	DNA repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	320.905	456.174	478.26	256.124	281.123	232.373
GO:0006281	DNA repair	biological_process	Escherichia	Escherichia coli	2.49661	0	1.30935	0	0	0.432112
GO:0006281	DNA repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.39196	3.53049	4.78845	3.00782	1.13571	2.26049
GO:0006282	regulation of DNA repair	biological_process	Clostridium	Clostridium thermocellum	0.928925	7.51585	2.96484	14.3278	13.304	20.4789
GO:0006282	regulation of DNA repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.3306	21.2501	25.7298	8.17725	8.29694	8.41684
GO:0006284	base-excision repair	biological_process	Clostridium	Clostridium thermocellum	9.10233	47.1933	46.9591	112.129	98.3745	179.749
GO:0006284	base-excision repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	35.2144	18.7453	22.4538	18.0727	28.9692	25.5127
GO:0006284	base-excision repair	biological_process	Escherichia	Escherichia coli	0.836059	0	0.324811	0	0	0
GO:0006284	base-excision repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.152529	0.164322	0.234426	0.290624	0.375099
GO:0006285	base-excision repair, AP site formation	biological_process	Escherichia	Escherichia coli	0.272497	0	0	0	0	0
GO:0006289	nucleotide-excision repair	biological_process	Clostridium	Clostridium thermocellum	10.5148	35.8935	31.0746	82.8924	74.6144	84.5537
GO:0006289	nucleotide-excision repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	23.0826	22.3576	15.9566	24.5116	23.5278	18.7787
GO:0006289	nucleotide-excision repair	biological_process	Escherichia	Escherichia coli	0.321834	0	0	0	0	0
GO:0006289	nucleotide-excision repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.230475	0.140161	0.308573	0.406079	0.22328	0.414002
GO:0006298	mismatch repair	biological_process	Clostridium	Clostridium thermocellum	2.98984	19.5161	13.0179	52.0287	52.5978	53.8572
GO:0006298	mismatch repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	34.6387	33.8197	30.2089	39.5389	47.3924	42.4149
GO:0006298	mismatch repair	biological_process	Escherichia	Escherichia coli	0.174187	0	0.221111	0	0	0
GO:0006298	mismatch repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.135471	1.14467	1.00474	0.277252	0.241922	0.342437
GO:0006302	double-strand break repair	biological_process	Clostridium	Clostridium thermocellum	1.90991	12.3852	7.99226	25.3602	28.2005	32.8534
GO:0006302	double-strand break repair	biological_process	Escherichia	Escherichia coli	0.12344	0	0	0	0	0
GO:0006302	double-strand break repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.17477	0.691003	0.0763199	0.0526003	0.109947	0.109435
GO:0006304	DNA modification	biological_process	Clostridium	Clostridium thermocellum	0.152192	0.0224967	0.0869199	0.0359373	0.0418215	0.0934594
GO:0006304	DNA modification	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.0579409	0.0445266	0.107534	0.011863	0.0827749	0.0308513
GO:0006304	DNA modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.391125	0.083988	0.277899	0	0.060215
GO:0006306	DNA methylation	biological_process	Clostridium	Clostridium thermocellum	0.114326	1.40912	0.709748	0.0874434	0.266751	0.145299
GO:0006306	DNA methylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.46258	3.89958	3.45221	6.18637	6.63148	3.68699
GO:0006306	DNA methylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0571388	0.192062	0	0.146112	0.102004	0.132978
GO:0006307	DNA dealkylation involved in DNA repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0	0.0848896
GO:0006308	DNA catabolic process	biological_process	Clostridium	Clostridium thermocellum	9.96534	32.9928	26.8289	117.871	107.577	100.856
GO:0006308	DNA catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0006310	DNA recombination	biological_process	Clostridium	Clostridium thermocellum	47.6532	242.043	175.334	593.376	560.301	580.451
GO:0006310	DNA recombination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	253.594	416.12	423.563	235.223	247.802	214.524
GO:0006310	DNA recombination	biological_process	Escherichia	Escherichia coli	3.46445	0	0.659004	0	0	0.299587
GO:0006310	DNA recombination	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.760352	0.941173	2.46962	1.61604	0.35315	1.0319
GO:0006313	transposition, DNA-mediated	biological_process	Clostridium	Clostridium thermocellum	53.4656	226.165	197.304	382.169	366.093	416.208
GO:0006313	transposition, DNA-mediated	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.2546	16.0043	18.9494	12.4801	8.90857	9.72214
GO:0006313	transposition, DNA-mediated	biological_process	Escherichia	Escherichia coli	10.6623	0	4.68705	0	0	1.63625
GO:0006313	transposition, DNA-mediated	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123683	0.356213	0.401717	0.253103	0.386681	0.493718
GO:0006351	transcription, DNA-templated	biological_process	Clostridium	Clostridium thermocellum	164.724	1325.19	1224.52	2960.81	2573.94	3008.1
GO:0006351	transcription, DNA-templated	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	963.689	1463.74	1175.16	759.157	866.563	813.038
GO:0006351	transcription, DNA-templated	biological_process	Escherichia	Escherichia coli	17.9065	0	10.8492	0	0	5.91291
GO:0006351	transcription, DNA-templated	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	32.0609	46.0881	31.7828	49.012	19.4615	56.3162
GO:0006352	DNA-templated transcription, initiation	biological_process	Clostridium	Clostridium thermocellum	54.2278	290.859	233.105	793.09	749.265	841.275
GO:0006352	DNA-templated transcription, initiation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	170.255	122.214	124.81	81.1139	113.434	92.5824
GO:0006352	DNA-templated transcription, initiation	biological_process	Escherichia	Escherichia coli	0.355301	0	0.204602	0	0	0
GO:0006352	DNA-templated transcription, initiation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.67367	7.50012	4.96851	4.06704	2.46463	4.71967
GO:0006353	DNA-templated transcription, termination	biological_process	Clostridium	Clostridium thermocellum	37.68	219.701	171.354	521.356	508.361	568.762
GO:0006353	DNA-templated transcription, termination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	121.719	157.281	136.164	149.221	188.105	134.129
GO:0006353	DNA-templated transcription, termination	biological_process	Escherichia	Escherichia coli	0.123319	0	0.0812816	0	0	0.0241572
GO:0006353	DNA-templated transcription, termination	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.172364	0.331009	0	0.881596	0.460688	0.800743
GO:0006354	DNA-templated transcription, elongation	biological_process	Clostridium	Clostridium thermocellum	11.3204	50.8585	32.9726	201.327	197.621	156.937
GO:0006354	DNA-templated transcription, elongation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	61.4545	80.1168	56.7512	84.885	109.133	88.1916
GO:0006354	DNA-templated transcription, elongation	biological_process	Escherichia	Escherichia coli	0.0613677	0	0	0	0	0
GO:0006355	regulation of transcription, DNA-templated	biological_process	Clostridium	Clostridium thermocellum	150.96	1377.26	1373.87	2729.98	2518.85	3040.49
GO:0006355	regulation of transcription, DNA-templated	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	938.636	1658.44	1172.12	751.274	813.121	749.815
GO:0006355	regulation of transcription, DNA-templated	biological_process	Escherichia	Escherichia coli	7.09773	0	3.97856	0	0	3.77544
GO:0006355	regulation of transcription, DNA-templated	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	9.55458	29.3612	16.6682	12.0298	8.20336	20.2803
GO:0006364	rRNA processing	biological_process	Clostridium	Clostridium thermocellum	21.6873	150.553	106.646	400.291	363.636	400.131
GO:0006364	rRNA processing	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	109.158	93.7532	82.9219	83.8596	105.482	68.8383
GO:0006364	rRNA processing	biological_process	Escherichia	Escherichia coli	0.261512	0	0	0	0	0.0680087
GO:0006364	rRNA processing	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.92549	2.10321	5.19553	8.02253	2.50775	6.84653
GO:0006367	transcription initiation from RNA polymerase II promoter	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.502243	3.85533	1.2821	0.642147	0.616732	1.91278
GO:0006378	mRNA polyadenylation	biological_process	Escherichia	Escherichia coli	0	0	0.0742451	0	0	0
GO:0006379	mRNA cleavage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.64781	1.76795	0.341726	3.57145	0.822085	6.1105
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	biological_process	Clostridium	Clostridium thermocellum	0.801937	6.93789	6.93591	10.7004	9.95663	15.0828
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265668	1.02598	0.991347	0.411078	0.0597915	0
GO:0006396	RNA processing	biological_process	Clostridium	Clostridium thermocellum	25.1889	100.817	77.7341	298.521	287.296	305.909
GO:0006396	RNA processing	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	135.44	105.201	98.5433	91.8139	104.844	82.173
GO:0006396	RNA processing	biological_process	Escherichia	Escherichia coli	0.363905	0	0.33505	0	0	0.135177
GO:0006396	RNA processing	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.884522	1.83147	2.64242	2.07016	1.054	2.3837
GO:0006397	mRNA processing	biological_process	Clostridium	Clostridium thermocellum	1.29891	6.48698	2.88541	28.1773	22.2648	16.6507
GO:0006400	tRNA modification	biological_process	Clostridium	Clostridium thermocellum	7.12204	59.4064	49.2044	167.6	152.573	140.148
GO:0006400	tRNA modification	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	59.3036	41.3259	25.5251	16.2168	19.669	14.5706
GO:0006400	tRNA modification	biological_process	Escherichia	Escherichia coli	0.160018	0	0.186605	0	0	0
GO:0006400	tRNA modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.414117	0.158737	0.461844	0.26335	0.147884	0.238047
GO:0006401	RNA catabolic process	biological_process	Clostridium	Clostridium thermocellum	6.60254	42.4215	39.2954	125.812	115.846	91.043
GO:0006401	RNA catabolic process	biological_process	Escherichia	Escherichia coli	0.218275	0	0.0815974	0	0	0.0966286
GO:0006401	RNA catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.13707	4.92523	4.37198	3.57137	1.55679	3.69284
GO:0006402	mRNA catabolic process	biological_process	Clostridium	Clostridium thermocellum	71.5998	419.342	309.158	1101.61	1106.11	1239.69
GO:0006402	mRNA catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	45.006100000000004	66.6318	57.0036	41.4935	47.6957	42.4064
GO:0006402	mRNA catabolic process	biological_process	Escherichia	Escherichia coli	0.157831	0	0	0	0	0
GO:0006412	translation	biological_process	Clostridium	Clostridium thermocellum	1143.89	7860.87	4330.21	25293.4	22865.7	29087
GO:0006412	translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	7168.49	8954.82	6667.55	9784.23	11084.7	8918.76
GO:0006412	translation	biological_process	Escherichia	Escherichia coli	2.16323	0	2.26208	0	0	1.02417
GO:0006412	translation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	28.3096	78.6725	98.6475	105.263	54.9794	86.1134
GO:0006414	translational elongation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.299178	0.578309	0.478277	1.11121	0.414617
GO:0006415	translational termination	biological_process	Clostridium	Clostridium thermocellum	4.57116	19.918	15.7805	60.6957	72.1577	83.0681
GO:0006415	translational termination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	29.1754	32.5188	25.8589	27.779	37.1724	34.0301
GO:0006417	regulation of translation	biological_process	Clostridium	Clostridium thermocellum	29.5781	51.7533	27.0008	262.427	196.911	154.505
GO:0006417	regulation of translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	19.8934	33.9467	29.8872	33.8104	51.1115	38.6829
GO:0006417	regulation of translation	biological_process	Escherichia	Escherichia coli	0.0640412	0	0	0	0	0.0213113
GO:0006417	regulation of translation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.54731	6.5134	2.81937	7.9523	4.54852	7.20401
GO:0006418	tRNA aminoacylation for protein translation	biological_process	Clostridium	Clostridium thermocellum	8.44719	22.8474	17.5299	64.1393	54.8431	56.0281
GO:0006418	tRNA aminoacylation for protein translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	31.5281	47.8248	39.7871	44.0812	45.2613	27.3038
GO:0006418	tRNA aminoacylation for protein translation	biological_process	Escherichia	Escherichia coli	0.0299426	0	0	0	0	0
GO:0006418	tRNA aminoacylation for protein translation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0335396	0.128866	0.0622468	0.0686415	0.02995	0.156229
GO:0006419	alanyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	5.49719	19.1865	11.5244	63.4788	64.6384	64.436
GO:0006419	alanyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.59223	6.15028	6.41724	6.8654	7.66215	7.15369
GO:0006419	alanyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0195891	0	0	0	0	0
GO:0006420	arginyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	14.0925	38.9658	49.3593	83.7525	86.937	71.8438
GO:0006420	arginyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	41.754	41.1333	32.755	51.7953	57.2362	34.3873
GO:0006420	arginyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.076655	0	0	0	0	0
GO:0006420	arginyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0792798	1.03517	0.646194	0.259569	0.184019	0.0843722
GO:0006421	asparaginyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.34199	16.3389	11.4461	45.0052	43.2546	38.7695
GO:0006421	asparaginyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.2449	20.8917	17.6842	13.8413	16.2779	15.6655
GO:0006421	asparaginyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0950045	0	0	0	0	0
GO:0006422	aspartyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0417544	0.0801853	0.154985	0.213386	0.0372856	0.138863
GO:0006423	cysteinyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	1.56572	12.2106	8.96696	28.6586	23.4713	15.921
GO:0006423	cysteinyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.6957	7.68243	4.86418	7.07781	9.52005	7.78834
GO:0006423	cysteinyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.039324	0	0.036491	0	0	0.0523243
GO:0006424	glutamyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	6.61953	33.0496	27.0863	99.7149	103.601	83.1163
GO:0006424	glutamyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1668	7.405	5.89757	6.48456	9.30782	6.88159
GO:0006424	glutamyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0384004	0	0	0	0	0
GO:0006424	glutamyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0321543	0.308746	0.0596757	0	0.0574259	0
GO:0006425	glutaminyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.33414	19.5644	13.4457	57.1243	62.2455	49.6799
GO:0006426	glycyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	4.03843	22.7861	16.3044	71.33	61.2833	62.8522
GO:0006426	glycyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	16.6999	6.40707	6.34443	9.92818	11.3027	9.74119
GO:0006426	glycyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.334229	0	0	0	0	0
GO:0006426	glycyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.0904535	0.349394	0.176727	0.0701004	0.0835637
GO:0006427	histidyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.63978	11.8759	8.04715	27.4492	23.7777	26.3258
GO:0006427	histidyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.6129	19.4776	14.613	22.3125	23.2156	14.0687
GO:0006427	histidyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0432126	0	0	0	0	0.0287493
GO:0006427	histidyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.307325	0.866309	0.228328	0.209879	0.256377	0.327464
GO:0006428	isoleucyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	55.1984	36.1391	27.3652	30.631	32.1575	26.0457
GO:0006428	isoleucyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.00911402	0	0.0338298	0	0	0
GO:0006428	isoleucyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0977023	0.156263	0.120885	0.13308	0.0581638	0.173336
GO:0006429	leucyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	5.48015	36.422	27.236	91.0435	87.979	79.0557
GO:0006429	leucyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	29.2374	12.0659	12.6704	13.3937	15.282	10.5045
GO:0006429	leucyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0199779	0	0	0	0	0.0265826
GO:0006429	leucyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.209841	0.140161	0.237034	0.140044	0.105889	0.169909
GO:0006430	lysyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	1.45601	14.2331	9.50287	38.4728	37.9494	40.2274
GO:0006430	lysyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	37.675	31.0372	19.2826	53.2743	51.8031	42.9871
GO:0006430	lysyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.112236	0	0.0659455	0	0	0.046471
GO:0006430	lysyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0981884	0.125739	0.121517	0.100475	0.0292338	0
GO:0006431	methionyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.43692	9.97597	6.73366	33.4126	30.0803	23.122
GO:0006431	methionyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	24.9197	13.0987	14.9571	14.1977	14.6997	10.6684
GO:0006431	methionyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0386921	0	0	0	0	0
GO:0006431	methionyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.103382	0.049932699999999997	0.275362	0.120169	0.143261
GO:0006432	phenylalanyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	1.97312	28.3832	22.7411	42.6145	37.7424	32.7753
GO:0006432	phenylalanyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	42.5364	32.6279	31.8027	38.7024	45.6252	27.2614
GO:0006432	phenylalanyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0434313	0	0.0540825	0	0	0
GO:0006432	phenylalanyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.153869	0.502441	0.12517	0.486012	0.204919	0.40194
GO:0006433	prolyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.52422	18.083	14.3411	44.9913	40.6442	43.3146
GO:0006433	prolyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	21.8478	24.8163	15.5358	30.7611	38.881100000000004	29.2867
GO:0006433	prolyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0309634	0	0	0	0	0
GO:0006433	prolyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0748079	0.143708	0.138837	0.228929	0.133603	0.0993774
GO:0006434	seryl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.40476	16.8858	13.3064	39.3101	43.4919	37.9766
GO:0006434	seryl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	7.1783	5.77516	2.36222	9.40884	9.56265	9.14085
GO:0006434	seryl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0212417	0	0	0	0	0
GO:0006434	seryl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.139675	0.167605	0.22675	0.303739	0.15587	0.232323
GO:0006435	threonyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	4.03547	29.0893	18.9049	72.3296	67.5599	52.1923
GO:0006435	threonyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	50.5135	73.2095	59.1197	59.8116	67.3875	40.0379
GO:0006435	threonyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0	0	0.0499778	0	0	0
GO:0006435	threonyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.116562	0.167885	0.162248	0.208735	0.117087	0.387776
GO:0006436	tryptophanyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	2.31474	19.8864	9.66349	46.4333	46.0442	41.3628
GO:0006436	tryptophanyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.7707	13.9259	10.8528	20.4638	22.8987	18.5213
GO:0006436	tryptophanyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.113597	0	0	0	0	0
GO:0006436	tryptophanyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.154209	0.395045	0.28638	0.39444	0.137792	0.0684291
GO:0006437	tyrosyl-tRNA aminoacylation	biological_process	Clostridium	Clostridium thermocellum	0.924769	11.7781	8.03421	31.9374	31.988	25.6617
GO:0006437	tyrosyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.46072	1.20339	1.41855	1.02027	1.26406	0.678696
GO:0006437	tyrosyl-tRNA aminoacylation	biological_process	Escherichia	Escherichia coli	0.0432126	0	0	0	0	0
GO:0006437	tyrosyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0300155	0.230474	0.111368	0.0307146	0.0535845	0.239437
GO:0006438	valyl-tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	52.0003	32.0423	38.9351	29.4323	33.8191	26.451
GO:0006438	valyl-tRNA aminoacylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.038206	0.348559	0.0354536	0.215052	0.12796	0.127124
GO:0006449	regulation of translational termination	biological_process	Clostridium	Clostridium thermocellum	0.853583	3.40601	1.55301	10.2901	11.8347	12.735900000000001
GO:0006449	regulation of translational termination	biological_process	Escherichia	Escherichia coli	0.033734	0	0.0626527	0	0	0.0224432
GO:0006450	regulation of translational fidelity	biological_process	Clostridium	Clostridium thermocellum	1.23156	5.96101	4.87076	16.4469	20.2092	20.5046
GO:0006450	regulation of translational fidelity	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.230816	0.0805587	0	0.128802	0.0562323	0.0837254
GO:0006452	translational frameshifting	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.299645	1.15242	0	0.920692	0.356883	1.19719
GO:0006457	protein folding	biological_process	Clostridium	Clostridium thermocellum	31.557	350.892	344.238	606.168	625.807	632.404
GO:0006457	protein folding	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	252.525	156.135	227.791	102.427	149.864	181.694
GO:0006457	protein folding	biological_process	Escherichia	Escherichia coli	0.255654	0	0.40519	0	0	0.0530681
GO:0006457	protein folding	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.22132	10.3413	10.4654	4.46938	4.56573	9.31994
GO:0006461	protein complex assembly	biological_process	Clostridium	Clostridium thermocellum	0.413995	2.15095	2.25884	18.9885	10.7841	9.65254
GO:0006461	protein complex assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.1449	13.6771	5.03229	7.06966	9.38825	10.6529
GO:0006461	protein complex assembly	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.185201	0.357829	0.788656	0.0861172	0.256674
GO:0006464	cellular protein modification process	biological_process	Clostridium	Clostridium thermocellum	0.217497	2.60971	0.706365	3.28263	1.65025	7.94968
GO:0006464	cellular protein modification process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	166.619	216.391	385.592	107.014	124.807	102.897
GO:0006464	cellular protein modification process	biological_process	Escherichia	Escherichia coli	0.717772	0	0.0994144	0	0	0
GO:0006464	cellular protein modification process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	3.51869	3.01918	5.77853	3.45685	3.36187	2.86076
GO:0006465	signal peptide processing	biological_process	Escherichia	Escherichia coli	0.0846024	0	0	0	0	0.0379012
GO:0006465	signal peptide processing	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.340816	0.979772	0.316556	0.261783	0.0761555	0.113477
GO:0006468	protein phosphorylation	biological_process	Escherichia	Escherichia coli	0.120597	0	0	0	0	0
GO:0006470	protein dephosphorylation	biological_process	Escherichia	Escherichia coli	0.242652	0	0.177945	0	0	0
GO:0006474	N-terminal protein amino acid acetylation	biological_process	Clostridium	Clostridium thermocellum	0.863936	4.81023	4.66521	16.7138	12.776	11.1884
GO:0006474	N-terminal protein amino acid acetylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	7.87636	3.88773	3.60458	1.22769	3.346	1.58729
GO:0006474	N-terminal protein amino acid acetylation	biological_process	Escherichia	Escherichia coli	0.0736413	0	0.135454	0	0	0
GO:0006474	N-terminal protein amino acid acetylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.227146	0.435745	0	0.309907	0.202835	0.20118
GO:0006479	protein methylation	biological_process	Escherichia	Escherichia coli	0.150126	0	0	0	0	0
GO:0006486	protein glycosylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.228774	0.391592	0.231305	0.153225	0.327671	0.202312
GO:0006493	protein O-linked glycosylation	biological_process	Clostridium	Clostridium thermocellum	2.50346	4.38419	2.69903	22.4856	20.2827	17.4859
GO:0006493	protein O-linked glycosylation	biological_process	Escherichia	Escherichia coli	0.0323487	0	0.0586834	0	0	0
GO:0006508	proteolysis	biological_process	Clostridium	Clostridium thermocellum	0.486081	5.91	2.38342	6.28965	5.7809	15.2818
GO:0006508	proteolysis	biological_process	Escherichia	Escherichia coli	1.45693	0	0.846285	0	0	0.170717
GO:0006511	ubiquitin-dependent protein catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.488463	0.781783	0.453319	0.166505	0.217876	1.0818
GO:0006515	misfolded or incompletely synthesized protein catabolic process	biological_process	Clostridium	Clostridium thermocellum	3.384	11.554	11.2844	33.3054	26.5787	30.8817
GO:0006515	misfolded or incompletely synthesized protein catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	14.3745	14.8853	9.86895	18.6179	26.4482	29.9665
GO:0006515	misfolded or incompletely synthesized protein catabolic process	biological_process	Escherichia	Escherichia coli	0.194675	0	0.218766	0	0	0.0530681
GO:0006520	cellular amino acid metabolic process	biological_process	Clostridium	Clostridium thermocellum	4.75844	179.434	126.828	508.831	598.8	832.114
GO:0006520	cellular amino acid metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	93.957	92.2553	107.802	72.9845	92.6523	81.1496
GO:0006520	cellular amino acid metabolic process	biological_process	Escherichia	Escherichia coli	0.51668	0	0.322285	0	0	0
GO:0006520	cellular amino acid metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.603664	0.353553	0.430044	0.305778	0.265665	0.88518
GO:0006522	alanine metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.111701	0.321908	0.103745	0	0.124727	0.0743471
GO:0006523	alanine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.52193	14.4972	11.4945	32.9542	31.4178	34.2164
GO:0006523	alanine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	29.9563	26.9304	27.2579	21.9174	19.4253	18.9558
GO:0006523	alanine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0446465	0	0	0	0	0
GO:0006525	arginine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	82.2044	17.393	23.6271	27.2268	30.7455	22.1183
GO:0006525	arginine metabolic process	biological_process	Escherichia	Escherichia coli	0.260928	0	0	0	0	0
GO:0006526	arginine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	7.94956	35.4299	30.2387	135.449	101.166	96.0519
GO:0006526	arginine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	110.225	64.4571	68.7743	37.0576	48.5997	48.8203
GO:0006526	arginine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.439563	0	0.139694	0	0	0.103581
GO:0006526	arginine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.20966	2.4042	1.89032	1.493	1.21436	3.2715
GO:0006527	arginine catabolic process	biological_process	Escherichia	Escherichia coli	0.0887584	0	0.0493915	0	0	0
GO:0006527	arginine catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.305059	0.147408	0	0	0
GO:0006528	asparagine metabolic process	biological_process	Escherichia	Escherichia coli	0.135471	0	0.0502936	0	0	0.0360579
GO:0006529	asparagine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.0574548	0.220626	0.106631	0.26422	0.205223	0.324909
GO:0006529	asparagine biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.452292
GO:0006529	asparagine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0771897	0.074071	0.286425	0.176802	0.0344425	0.256641
GO:0006531	aspartate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.274417	0.316447	0.10176	0.224826	0.637198	0.219193
GO:0006531	aspartate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.244572	0.104409	0.756839	0.862297	0.194176	0.506492
GO:0006535	cysteine biosynthetic process from serine	biological_process	Clostridium	Clostridium thermocellum	9.21889	942.806	640.11	1470.31	1286.49	1136.76
GO:0006535	cysteine biosynthetic process from serine	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.37537	20.7263	18.0253	14.2907	15.7527	11.2618
GO:0006535	cysteine biosynthetic process from serine	biological_process	Escherichia	Escherichia coli	0.0662285	0	0.109744	0	0	0
GO:0006536	glutamate metabolic process	biological_process	Escherichia	Escherichia coli	0.27867	0	0	0	0	0.0517099
GO:0006537	glutamate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.0358485	4.2676	11.7037	15.034	23.2169	30.3742
GO:0006537	glutamate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	8.8536	7.17812	8.30773	2.55001	3.206	4.34188
GO:0006537	glutamate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.133259	0	0.113894	0	0	0
GO:0006537	glutamate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.295076	0.463002	0.367572	1.10774	0.474339	0.297194
GO:0006541	glutamine metabolic process	biological_process	Clostridium	Clostridium thermocellum	18.3298	83.207	52.1163	271.671	262.208	228.773
GO:0006541	glutamine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	153.962	75.4199	72.4702	69.8816	83.9803	51.9815
GO:0006541	glutamine metabolic process	biological_process	Escherichia	Escherichia coli	0.487029	0	0.0439787	0	0	0.146657
GO:0006541	glutamine metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.04323	2.65503	2.14445	2.96146	1.79075	3.39332
GO:0006542	glutamine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.24208	10.5026	19.1823	47.285	51.3849	47.0985
GO:0006542	glutamine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	89.8945	66.5803	94.2909	35.8416	41.9936	38.8995
GO:0006542	glutamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.212272	0	0	0	0	0
GO:0006542	glutamine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.12344	0.0791584	0.229546	0.126465	0.0368081	0.164573
GO:0006543	glutamine catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.652544	0.420797	1.67843	0.202358	1.1316
GO:0006544	glycine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	33.2716	51.5545	66.8396	27.4989	35.3101	21.7446
GO:0006545	glycine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.66723	34.7584	21.8931	95.8256	97.9612	69.4259
GO:0006555	methionine metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.220584	3.75139	3.04175	10.2494	9.54049	13.2489
GO:0006555	methionine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.722657	0.346785	0.335366	0.154046	0.484084	0.24044
GO:0006556	S-adenosylmethionine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.44273	25.2447	17.4504	80.409	108.614	87.4991
GO:0006556	S-adenosylmethionine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	27.8182	10.2815	7.51373	26.666	34.968	18.8696
GO:0006556	S-adenosylmethionine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.13462	0.215492	0.0833114	0.183691	0.320661	0.298617
GO:0006557	S-adenosylmethioninamine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	17.8211	150.459	93.7517	655.139	644.823	950.994
GO:0006557	S-adenosylmethioninamine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	91.4887	110.189	143.464	72.4909	93.239	81.7297
GO:0006557	S-adenosylmethioninamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.0699148	0	0	0.0501253
GO:0006561	proline biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.540085	2.86455	2.88893	11.9237	4.87905	5.78973
GO:0006561	proline biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	40.8268	47.4838	37.6034	33.4503	33.3063	29.2921
GO:0006561	proline biosynthetic process	biological_process	Escherichia	Escherichia coli	0.00636766	0	0	0	0	0
GO:0006561	proline biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.371609	0.127419	0.332163	0.366237	0.308116	0.511892
GO:0006564	L-serine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.83627	38.8084	29.9703	82.1011	81.3638	64.717
GO:0006564	L-serine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0224326	0	0.206136	0	0	0
GO:0006564	L-serine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.179121	0.675647	0.395673	0.451492	0.722751	1.06285
GO:0006569	tryptophan catabolic process	biological_process	Escherichia	Escherichia coli	0.221993	0	0.199641	0	0	0.134886
GO:0006570	tyrosine metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0258109	0.148609	0	0.369296	0.115025	0
GO:0006571	tyrosine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.38371	16.3874	12.5114	61.2005	62.8299	58.0045
GO:0006571	tyrosine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0698499	0	0	0	0	0
GO:0006571	tyrosine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.2427	0.544541	0.41349	0.496905	0.289343	0.565963
GO:0006593	ornithine catabolic process	biological_process	Escherichia	Escherichia coli	0.0680757	0	0	0	0	0
GO:0006605	protein targeting	biological_process	Clostridium	Clostridium thermocellum	49.1403	203.27	133.526	944.343	781.244	838.359
GO:0006605	protein targeting	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	229.033	209.599	183.924	204.744	292.953	237.531
GO:0006605	protein targeting	biological_process	Escherichia	Escherichia coli	0.130464	0	0.283087	0	0	0.0273587
GO:0006605	protein targeting	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.479884	0.348138	0.905871	0.768238	0.663957	0.866585
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological_process	Clostridium	Clostridium thermocellum	5.75785	37.1508	25.7878	104.476	103.333	103.266
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.7115	17.1426	18.7198	10.9277	14.4437	12.0794
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological_process	Escherichia	Escherichia coli	0.0181551	0	0	0	0	0
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.32231	0.877791	1.02031	1.39887	1.12061	0.698649
GO:0006627	protein processing involved in protein targeting to mitochondrion	biological_process	Clostridium	Clostridium thermocellum	2.75139	29.8022	17.9531	85.0748	71.176	68.1265
GO:0006629	lipid metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	83.4374	87.955	117.991	64.8213	72.8441	53.7094
GO:0006629	lipid metabolic process	biological_process	Escherichia	Escherichia coli	0.118312	0	0	0	0	0
GO:0006629	lipid metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.359773	0.138901	0.335591	0.147927	0.0322939	0
GO:0006631	fatty acid metabolic process	biological_process	Escherichia	Escherichia coli	0.222188	0	0	0	0	0.0960142
GO:0006633	fatty acid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	37.526	210.249	125.572	805.318	642.782	578.118
GO:0006633	fatty acid biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	289.769	157.706	129.753	180.723	215.893	161.83
GO:0006633	fatty acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.172559	0	0.966629	0	0	0.0539089
GO:0006635	fatty acid beta-oxidation	biological_process	Escherichia	Escherichia coli	0.194262	0	0.0881829	0	0	0.0158461
GO:0006641	triglyceride metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0006646	phosphatidylethanolamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0296752	0	0	0	0	0
GO:0006646	phosphatidylethanolamine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.35766	0.172802	0.19058	0.415611	0.803427
GO:0006650	glycerophospholipid metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0006650	glycerophospholipid metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.14437	4.0171	3.62457	3.57142	2.38044	3.65433
GO:0006655	phosphatidylglycerol biosynthetic process	biological_process	Escherichia	Escherichia coli	0.060906	0	0.244476	0	0	0.175277
GO:0006662	glycerol ether metabolic process	biological_process	Clostridium	Clostridium thermocellum	38.8844	434.038	334.012	974.87	757.718	1469.5
GO:0006662	glycerol ether metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	66.74	167.601	230.571	124.749	143.671	96.3272
GO:0006662	glycerol ether metabolic process	biological_process	Escherichia	Escherichia coli	0.0685131	0	0	0	0	0
GO:0006662	glycerol ether metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.450087	2.58903	0.41764	0.690842	0.801966	1.19499
GO:0006665	sphingolipid metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.10134	2.62324	4.47595	5.63485	5.90085	6.5278
GO:0006725	cellular aromatic compound metabolic process	biological_process	Clostridium	Clostridium thermocellum	6.5338	41.5837	28.6976	66.6847	86.606	106.486
GO:0006725	cellular aromatic compound metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	62.4891	45.4467	49.2424	37.3337	55.9564	46.8678
GO:0006725	cellular aromatic compound metabolic process	biological_process	Escherichia	Escherichia coli	0.109417	0	0	0	0	0
GO:0006725	cellular aromatic compound metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.14213	0.272947	0.263692	1.65272	0.0317297	0
GO:0006730	one-carbon metabolic process	biological_process	Clostridium	Clostridium thermocellum	9.85743	229.335	225.962	278.674	300.875	271.853
GO:0006730	one-carbon metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	44.7513	32.178	26.851	55.7994	72.6024	40.7809
GO:0006730	one-carbon metabolic process	biological_process	Escherichia	Escherichia coli	0.0654265	0	0.365136	0	0	0
GO:0006730	one-carbon metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	40.6945	18.8299	54.8542	42.8272	37.4459	71.7083
GO:0006734	NADH metabolic process	biological_process	Escherichia	Escherichia coli	0.0330049	0	0	0	0	0
GO:0006739	NADP metabolic process	biological_process	Escherichia	Escherichia coli	0.0953691	0	0.07208	0	0	0.0517099
GO:0006740	NADPH regeneration	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.339924	0.246461	0	0.276647	0.0588891
GO:0006741	NADP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.27337	43.3958	38.1945	99.6322	94.2849	136.194
GO:0006741	NADP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	30.4671	40.6183	32.4355	23.0473	31.7517	24.0679
GO:0006741	NADP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.233368	0	0	0	0	0
GO:0006741	NADP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.207727	0.398826	0.192649	0.070855	0.15459	0
GO:0006744	ubiquinone biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	9.60649	78.6496	60.5386	280.636	190.9	185.378
GO:0006744	ubiquinone biosynthetic process	biological_process	Escherichia	Escherichia coli	0.267418	0	0.122915	0	0	0.154774
GO:0006744	ubiquinone biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.173288	0.290917	0.321247	0.177324	0.0580336	0.0576602
GO:0006747	FAD biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.18476	13.2453	14.3414	40.3507	33.9304	35.5191
GO:0006747	FAD biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.502	12.0994	6.78476	11.8856	12.0771	13.8432
GO:0006747	FAD biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0794256	0.457588	0.588683	1.70599	0.70834	0.422734
GO:0006749	glutathione metabolic process	biological_process	Escherichia	Escherichia coli	0.227364	0	0.0750119	0	0	0
GO:0006750	glutathione biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0	1.46588	1.69992	1.48547	0.477746	0.915255
GO:0006750	glutathione biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0455458	0	0	0	0	0
GO:0006772	thiamine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.52963	3.21931	2.74946	2.52561	2.69027	2.35556
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	121.76	47.0808	42.6733	35.536	42.2358	31.167
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	biological_process	Escherichia	Escherichia coli	0.272594	0	0.329637	0	0	0.0743471
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.07089	2.3671	1.79041	4.05542	1.54603	3.54971
GO:0006779	porphyrin-containing compound biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.10579	177.859	180.352	89.2808	88.7406	94.6287
GO:0006779	porphyrin-containing compound biosynthetic process	biological_process	Escherichia	Escherichia coli	0.377636	0	0.173569	0	0	0
GO:0006779	porphyrin-containing compound biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.301954	0.655951	0.0781693	0.570197	0.664196	0.752138
GO:0006782	protoporphyrinogen IX biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.52645	14.6026	15.6358	31.3887	23.3237	22.4876
GO:0006782	protoporphyrinogen IX biosynthetic process	biological_process	Escherichia	Escherichia coli	0.329223	0	0.429232	0	0	0
GO:0006782	protoporphyrinogen IX biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.509875	1.31531	2.35099	1.19889	0.689805	1.33223
GO:0006783	heme biosynthetic process	biological_process	Escherichia	Escherichia coli	0.149008	0	0.109338	0	0	0
GO:0006790	sulfur compound metabolic process	biological_process	Escherichia	Escherichia coli	0.189596	0	0	0	0	0
GO:0006793	phosphorus metabolic process	biological_process	Escherichia	Escherichia coli	0.0349249	0	0.0648178	0	0	0
GO:0006796	phosphate-containing compound metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.122518	0	0.19547900000000001	0.170889	0.169747
GO:0006805	xenobiotic metabolic process	biological_process	Escherichia	Escherichia coli	0.431008	0	0	0	0	0
GO:0006807	nitrogen compound metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.91424	18.0432	28.1874	80.3704	75.4314	96.7531
GO:0006807	nitrogen compound metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	68.7203	92.6506	77.1084	82.9228	92.4925	80.5627
GO:0006807	nitrogen compound metabolic process	biological_process	Escherichia	Escherichia coli	0.20797	0	0.141183	0	0	0.101221
GO:0006807	nitrogen compound metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.134733	0.631801	0.129762	0
GO:0006808	regulation of nitrogen utilization	biological_process	Clostridium	Clostridium thermocellum	29.5502	131.469	92.9205	281.49	268.928	416.262
GO:0006808	regulation of nitrogen utilization	biological_process	Escherichia	Escherichia coli	0.134815	0	0.0358144	0	0	0
GO:0006808	regulation of nitrogen utilization	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.642259	1.17865	0.205956	0.531599	0.464442	1.83536
GO:0006810	transport	biological_process	Clostridium	Clostridium thermocellum	126.041	523.997	464.856	1379.54	1287.84	1186.42
GO:0006810	transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1622.31	749.489	1107.24	532.472	668.228	543.656
GO:0006810	transport	biological_process	Escherichia	Escherichia coli	2.83757	0	2.04332	0	0	0.751912
GO:0006810	transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.49299	3.65851	3.28478	4.16726	2.65761	4.40695
GO:0006811	ion transport	biological_process	Escherichia	Escherichia coli	1.85792	0	1.65283	0	0	0.833373
GO:0006813	potassium ion transport	biological_process	Clostridium	Clostridium thermocellum	0.298211	3.37077	2.55194	7.38812	7.07064	9.19162
GO:0006813	potassium ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	58.6051	41.5047	41.8137	28.3159	34.0254	28.5067
GO:0006813	potassium ion transport	biological_process	Escherichia	Escherichia coli	0.626802	0	0.261166	0	0	0.120139
GO:0006813	potassium ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.692204	1.49407	0.948541	2.37574	0.798038	1.33123
GO:0006814	sodium ion transport	biological_process	Clostridium	Clostridium thermocellum	5.74186	19.6854	17.1418	81.1865	67.3804	47.0333
GO:0006814	sodium ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	45.0709	41.4527	36.131100000000004	39.6496	43.8495	39.3051
GO:0006814	sodium ion transport	biological_process	Escherichia	Escherichia coli	1.47173	0	0.0728919	0	0	0.0506427
GO:0006814	sodium ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	4.65863	2.91715	9.59719	11.576	11.255	11.281
GO:0006817	phosphate ion transport	biological_process	Clostridium	Clostridium thermocellum	2.90847	19.9349	16.6952	32.2327	38.368	43.4403
GO:0006817	phosphate ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	90.0587	23.2862	17.7497	20.0183	25.6122	19.0488
GO:0006817	phosphate ion transport	biological_process	Escherichia	Escherichia coli	0.180774	0	0.310332	0	0	0.240666
GO:0006817	phosphate ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.379945	0.730255	1.63592	1.10871	0.585046	1.07029
GO:0006820	anion transport	biological_process	Escherichia	Escherichia coli	0.0715025	0	0.484532	0	0	0
GO:0006824	cobalt ion transport	biological_process	Clostridium	Clostridium thermocellum	4.31181	28.5606	28.0658	49.5695	39.6386	32.0258
GO:0006824	cobalt ion transport	biological_process	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0.0478292
GO:0006824	cobalt ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.118691	0.390531	0.452686	0.0626346	0.561953
GO:0006825	copper ion transport	biological_process	Clostridium	Clostridium thermocellum	9.2649	157.246	73.6162	357.928	224.203	535.128
GO:0006825	copper ion transport	biological_process	Escherichia	Escherichia coli	0.00814186	0	0	0	0	0
GO:0006826	iron ion transport	biological_process	Clostridium	Clostridium thermocellum	6.25628	115.39	79.7483	294.479	169.316	373.564
GO:0006826	iron ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	62.6168	22.0141	74.5188	8.50255	16.5574	18.8664
GO:0006826	iron ion transport	biological_process	Escherichia	Escherichia coli	0.139675	0	0.660312	0	0	0.228507
GO:0006826	iron ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.398416	0	0.246461	0.203661	0	0
GO:0006829	zinc II ion transport	biological_process	Escherichia	Escherichia coli	0.708001	0	0.311144	0	0	0
GO:0006835	dicarboxylic acid transport	biological_process	Escherichia	Escherichia coli	0.10441	0	0.0387464	0	0	0
GO:0006855	drug transmembrane transport	biological_process	Escherichia	Escherichia coli	0.501247	0	0.178802	0	0	0.0780984
GO:0006858	extracellular transport	biological_process	Escherichia	Escherichia coli	0	0	0.466219	0	0	0.103646
GO:0006865	amino acid transport	biological_process	Clostridium	Clostridium thermocellum	0.86763	4.62619	3.22208	16.2786	12.353	21.5471
GO:0006865	amino acid transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	81.1355	2.4807	4.76494	2.9156	3.13553	2.95316
GO:0006865	amino acid transport	biological_process	Escherichia	Escherichia coli	1.41428	0	0.360851	0	0	0.584914
GO:0006865	amino acid transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.195469	0	0.10428	0	0.271194
GO:0006869	lipid transport	biological_process	Escherichia	Escherichia coli	0.173069	0	0	0	0	0
GO:0006874	cellular calcium ion homeostasis	biological_process	Escherichia	Escherichia coli	0.0880536	0	0	0	0	0
GO:0006879	cellular iron ion homeostasis	biological_process	Clostridium	Clostridium thermocellum	6.25628	115.39	79.7483	294.479	169.316	373.564
GO:0006879	cellular iron ion homeostasis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	236.703	159.995	199.796	179.002	193.502	146.835
GO:0006879	cellular iron ion homeostasis	biological_process	Escherichia	Escherichia coli	0.2855	0	0.660312	0	0	0.300461
GO:0006879	cellular iron ion homeostasis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.25642	0.1768	0.246461	0.297869	0.0822106	0.726687
GO:0006885	regulation of pH	biological_process	Escherichia	Escherichia coli	0.0955635	0	0.177403	0	0	0
GO:0006935	chemotaxis	biological_process	Clostridium	Clostridium thermocellum	39.9011	153.227	121.301	1091.54	990.623	840.94
GO:0006935	chemotaxis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	36.7895	23.57	28.1773	7.00877	10.335	10.4379
GO:0006935	chemotaxis	biological_process	Escherichia	Escherichia coli	0.261828	0	0.113623	0	0	0.248654
GO:0006950	response to stress	biological_process	Clostridium	Clostridium thermocellum	13.0814	162.03	293.87	116.541	163.317	222.705
GO:0006950	response to stress	biological_process	Escherichia	Escherichia coli	0.385365	0	0.425443	0	0	0.0942679
GO:0006950	response to stress	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.26432	5.3733	5.97118	5.52763	3.27925	4.85112
GO:0006970	response to osmotic stress	biological_process	Escherichia	Escherichia coli	0.398416	0	0	0	0	0
GO:0006972	hyperosmotic response	biological_process	Escherichia	Escherichia coli	0.0460319	0	0	0	0	0
GO:0006974	cellular response to DNA damage stimulus	biological_process	Escherichia	Escherichia coli	5.0368	0	2.84125	0	0	1.53086
GO:0006979	response to oxidative stress	biological_process	Clostridium	Clostridium thermocellum	16.883	200.229	148.232	506.966	347.335	664.317
GO:0006979	response to oxidative stress	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	33.573	20.5479	34.6584	24.9246	33.2927	30.7519
GO:0006979	response to oxidative stress	biological_process	Escherichia	Escherichia coli	1.7608	0	0.323773	0	0	0.506395
GO:0006979	response to oxidative stress	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.562542	0.259319	0.250611	0.162278	0	0.106039
GO:0007049	cell cycle	biological_process	Clostridium	Clostridium thermocellum	87.6465	623.172	492.517	1658.04	1523.41	1746.42
GO:0007049	cell cycle	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	297.796	313.98	266.957	271.272	297.044	221.046
GO:0007049	cell cycle	biological_process	Escherichia	Escherichia coli	1.82285	0	0.593464	0	0	0.632937
GO:0007049	cell cycle	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110778	0.060769	0.117502	0.145714	0.0847716	0.126316
GO:0007059	chromosome segregation	biological_process	Clostridium	Clostridium thermocellum	6.72379	45.7892	39.4453	121.488	116.209	186.388
GO:0007059	chromosome segregation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.2546	16.0043	18.9494	12.4801	8.90857	9.72214
GO:0007059	chromosome segregation	biological_process	Escherichia	Escherichia coli	0.279472	0	0.0112766	0	0	0
GO:0007059	chromosome segregation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123683	0.356213	0.401717	0.253103	0.386681	0.493718
GO:0007062	sister chromatid cohesion	biological_process	Escherichia	Escherichia coli	0.0836546	0	0	0	0	0
GO:0007155	cell adhesion	biological_process	Clostridium	Clostridium thermocellum	4.5617	21.9151	16.9857	121.04	115.348	113.012
GO:0007155	cell adhesion	biological_process	Escherichia	Escherichia coli	2.14184	0	1.28882	0	0	0.662333
GO:0007155	cell adhesion	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.296339	0.31612	0	0.269493	0.176445	0.131458
GO:0007165	signal transduction	biological_process	Clostridium	Clostridium thermocellum	0.354013	0.723114	0.509972	3.33183	2.72595	2.76181
GO:0007165	signal transduction	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0235751
GO:0007186	G-protein coupled receptor signaling pathway	biological_process	Escherichia	Escherichia coli	0.361523	0	0.379841	0	0	0.0899345
GO:0007446	imaginal disc growth	biological_process	Clostridium	Clostridium thermocellum	0.844128	1.36483	0.989498	14.7573	12.6659	10.6787
GO:0007446	imaginal disc growth	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0151414	0.116311	0.168608	0.123953	0.0946464	0.362616
GO:0007608	sensory perception of smell	biological_process	Escherichia	Escherichia coli	0.361523	0	0.379841	0	0	0.0899345
GO:0008026	ATP-dependent helicase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0605657	0.0581553	0.22481	0.108459	0.0809953	0.181324
GO:0008033	tRNA processing	biological_process	Clostridium	Clostridium thermocellum	8.31952	51.1094	43.9072	135.764	123.42	117.665
GO:0008033	tRNA processing	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	37.0863	31.6207	25.6656	32.4106	35.0013	24.7912
GO:0008033	tRNA processing	biological_process	Escherichia	Escherichia coli	0.480637	0	0.182185	0	0	0
GO:0008033	tRNA processing	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.579141	0.828223	1.13497	0.876174	0.548867	1.08604
GO:0008047	enzyme activator activity	molecular_function	Escherichia	Escherichia coli	0.0704575	0	0	0	0	0
GO:0008047	enzyme activator activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.15724	1.42733	6.11376	1.58348	2.86908	1.84513
GO:0008073	ornithine decarboxylase inhibitor activity	molecular_function	Escherichia	Escherichia coli	0.0983099	0	0.072937	0	0	0
GO:0008080	N-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	31.4505	94.0007	69.4138	446.086	347.924	492.377
GO:0008080	N-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.1521	21.4199	16.3102	13.8887	15.5413	13.1466
GO:0008080	N-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.484647	0	0.0994144	0	0	0
GO:0008080	N-acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.292475	1.06915	0.466806	0.760503	0.384402	0.401132
GO:0008081	phosphoric diester hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0576492	0	0	0	0	0
GO:0008094	DNA-dependent ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	16.5444	106.025	77.9981	221.871	221.813	226.413
GO:0008094	DNA-dependent ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	75.3055	93.129	134.803	48.402	58.49	53.6726
GO:0008094	DNA-dependent ATPase activity	molecular_function	Escherichia	Escherichia coli	0.139748	0	0	0	0	0.0384186
GO:0008094	DNA-dependent ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.649574	0.880404	2.35212	1.47032	0.193286	0.658258
GO:0008097	5S rRNA binding	molecular_function	Clostridium	Clostridium thermocellum	1.0118	1.38261	0	6.06257	3.34383	4.79799
GO:0008097	5S rRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	47.7832	66.6101	38.517	77.8544	102.211	85.4707
GO:0008097	5S rRNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.169837	1.30406	0.735775	0.753366	0.505895	0.975341
GO:0008106	alcohol dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.105261	0	0	0	0	0.0743148
GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.59595	13.7924	5.45755	15.3531	18.278	12.0259
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	molecular_function	Clostridium	Clostridium thermocellum	0.217497	2.60971	0.706365	3.28263	1.65025	7.94968
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.85163	2.10927	1.80651	1.83144	1.68072	1.29517
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	molecular_function	Escherichia	Escherichia coli	0.0994036	0	0	0	0	0
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.403958	0.259319	0.250611	0	0	0
GO:0008115	sarcosine oxidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	24.9721	21.0834	19.3698	18.0473	21.2332	16.4641
GO:0008121	ubiquinol-cytochrome-c reductase activity	molecular_function	Clostridium	Clostridium thermocellum	0.170857	0.787664	0.539201	1.69599	1.54104	2.41028
GO:0008131	primary amine oxidase activity	molecular_function	Escherichia	Escherichia coli	0.0686346	0	0	0	0	0
GO:0008134	transcription factor binding	molecular_function	Escherichia	Escherichia coli	0.0430911	0	0	0	0	0
GO:0008137	NADH dehydrogenase (ubiquinone) activity	molecular_function	Clostridium	Clostridium thermocellum	14.3932	138.42	72.764	533.184	488.292	520.938
GO:0008137	NADH dehydrogenase (ubiquinone) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	114.261	138.653	121.844	161.211	169.648	101.808
GO:0008137	NADH dehydrogenase (ubiquinone) activity	molecular_function	Escherichia	Escherichia coli	0.514347	0	0.0653591	0	0	0.106557
GO:0008137	NADH dehydrogenase (ubiquinone) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123853	0.409561	0.12941	1.09162	0.659269	0.401132
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0208286	0	0.177945	0	0	0
GO:0008143	poly(A) binding	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.027294
GO:0008143	poly(A) binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.759696	2.22096	1.62162	1.49129	0.460601	0.920041
GO:0008152	metabolic process	biological_process	Clostridium	Clostridium thermocellum	11.168	16.4009	29.6268	72.423	52.9498	59.8253
GO:0008152	metabolic process	biological_process	Escherichia	Escherichia coli	0.0251547	0	0	0	0	0
GO:0008152	metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.511989	1.15709	0.932213	0.64635	0.758039	1.31066
GO:0008168	methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	24.4054	333.039	291.441	657.494	589.854	592.538
GO:0008168	methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	210.994	200.193	203.621	142.107	171.568	148.81
GO:0008168	methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.296266	0	0.33523	0	0	0.256674
GO:0008168	methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.46826	3.50001	2.88031	2.92843	2.29107	2.82325
GO:0008170	N-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.114326	8.09129	5.53351	1.43152	1.85276	1.02906
GO:0008170	N-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.46258	3.89958	3.45221	6.18637	6.63148	3.68699
GO:0008170	N-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0768494	0	0.071268	0	0	0
GO:0008170	N-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0571388	0.192062	0	0.146112	0.102004	0.132978
GO:0008171	O-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.298211	2.00458	0.36897	5.43305	5.09589	4.95522
GO:0008173	RNA methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	16.5154	41.3666	32.725	101.785	92.4117	109.412
GO:0008173	RNA methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	62.1147	20.9657	24.0939	28.4997	33.7371	24.2185
GO:0008173	RNA methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0848211	0.0813054	0.0787106	0.303739	0	0
GO:0008175	tRNA methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.704259	6.47027	5.88268	16.0671	16.4713	25.6325
GO:0008175	tRNA methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.103709	0.400725	0.331593	0	0
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.19758	22.9953	17.6967	38.2731	45.5668	49.7891
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.27006	5.18488	3.72714	2.75951	2.54302	1.27764
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0426293	0	0	0	0	0
GO:0008177	succinate dehydrogenase (ubiquinone) activity	molecular_function	Escherichia	Escherichia coli	0.0830956	0	0	0	0	0
GO:0008184	glycogen phosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	2.1006	8.77968	7.46055	66.069	52.7995	53.1133
GO:0008184	glycogen phosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.0012	10.3973	8.3927600000000009	14.0098	14.1239	9.89496
GO:0008184	glycogen phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.148984	0	0.0803795	0	0	0.0281348
GO:0008186	RNA-dependent ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	10.1748	24.4047	29.7108	58.603	55.1107	60.7126
GO:0008186	RNA-dependent ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	48.4172	47.7495	49.7599	47.5107	53.7822	25.0062
GO:0008186	RNA-dependent ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0437959	0	0.0812816	0	0	0.027294
GO:0008198	ferrous iron binding	molecular_function	Clostridium	Clostridium thermocellum	3.19713	20.6728	23.0402	38.1483	43.2343	41.2012
GO:0008198	ferrous iron binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	62.4891	45.4467	49.2424	37.3337	55.9564	46.8678
GO:0008198	ferrous iron binding	molecular_function	Escherichia	Escherichia coli	0.159435	0	0	0	0	0
GO:0008198	ferrous iron binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.403204	0.861642	1.07642	0.503371	0.0707732	0.174792
GO:0008199	ferric iron binding	molecular_function	Clostridium	Clostridium thermocellum	6.25628	115.39	79.7483	294.479	169.316	373.564
GO:0008199	ferric iron binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	236.703	159.995	199.796	179.002	193.502	146.835
GO:0008199	ferric iron binding	molecular_function	Escherichia	Escherichia coli	0.350464	0	0.660312	0	0	0.197785
GO:0008199	ferric iron binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.25642	0.1768	0.246461	0.297869	0.0822106	0.726687
GO:0008216	spermidine metabolic process	biological_process	Escherichia	Escherichia coli	0.0852829	0	0	0	0	0
GO:0008233	peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	33.4122	124.989	104.637	327.936	309.368	384.097
GO:0008233	peptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	246.804	144.137	193.867	103.974	137.478	113.159
GO:0008233	peptidase activity	molecular_function	Escherichia	Escherichia coli	0.281562	0	0.387373	0	0	0.0229283
GO:0008233	peptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.64777	3.59765	4.19178	3.63892	2.71909	3.41373
GO:0008234	cysteine-type peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	7.07246	25.0548	21.4841	39.2775	35.7906	61.1063
GO:0008234	cysteine-type peptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	41.2371	71.3365	60.2322	79.0146	88.6953	67.4213
GO:0008234	cysteine-type peptidase activity	molecular_function	Escherichia	Escherichia coli	0.407871	0	0.207625	0	0	0
GO:0008235	metalloexopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.309172	1.84039	0.688639	4.5854799999999996	4.02984	5.22299
GO:0008235	metalloexopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0461291	0	0.0378893	0	0	0
GO:0008236	serine-type peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	12.2412	71.1457	51.4994	188.429	169.436	184.402
GO:0008236	serine-type peptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	196.107	125.357	126.794	93.0754	104.644	89.5583
GO:0008236	serine-type peptidase activity	molecular_function	Escherichia	Escherichia coli	0.0511843	0	0	0	0	0.0379012
GO:0008236	serine-type peptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.206293	0.395139	0.861892	0.475119	0.368624	0.137311
GO:0008237	metallopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	6.52338	33.9952	27.8926	100.731	88.4149	81.925
GO:0008237	metallopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	189.094	153.94	216.378	178.381	199.241	115.163
GO:0008237	metallopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.727834	0	0.841324	0	0	0.199531
GO:0008237	metallopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.6775	0.504355	0.942091	0.720885	0.324046	0.924407
GO:0008239	dipeptidyl-peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.309172	1.84039	0.688639	4.5854799999999996	4.02984	5.22299
GO:0008251	tRNA-specific adenosine deaminase activity	molecular_function	Escherichia	Escherichia coli	0.068659	0	0	0	0	0
GO:0008252	nucleotidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.116555	0	0	0.0883498
GO:0008253	5'-nucleotidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.467391	8.36461	6.45373	16.038	10.6595	18.6532
GO:0008253	5'-nucleotidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	312.975	70.6242	119.511	53.59	62.7981	51.8206
GO:0008253	5'-nucleotidase activity	molecular_function	Escherichia	Escherichia coli	0.177371	0	0	0	0	0
GO:0008253	5'-nucleotidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.141183	0	0.13586	0
GO:0008254	3'-nucleotidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.161661	0	0	0
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.272497	0	0	0	0	0
GO:0008270	zinc ion binding	molecular_function	Clostridium	Clostridium thermocellum	121.632	845.19	691.368	2038.04	1960.51	2121.12
GO:0008270	zinc ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	531.423	413.505	476.427	326.229	408.752	358.994
GO:0008270	zinc ion binding	molecular_function	Escherichia	Escherichia coli	4.09348	0	1.76447	0	0	1.82818
GO:0008270	zinc ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	11.9165	47.7652	52.1486	63.5636	19.6411	44.476
GO:0008271	secondary active sulfate transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.738989	113.725	100.607	227.825	204.608	207.385
GO:0008271	secondary active sulfate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.293933	0	0.904563	0	0	0
GO:0008273	calcium, potassium:sodium antiporter activity	molecular_function	Escherichia	Escherichia coli	0.0880536	0	0	0	0	0
GO:0008276	protein methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.12718	33.8063	26.6336	52.0638	60.7265	63.5674
GO:0008276	protein methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.5106	5.65722	5.81867	5.00208	6.73144	3.92394
GO:0008276	protein methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0663987	0	0.123231	0	0	0
GO:0008276	protein methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.4531	1.89542	0.896399	0.760503	0.416696	0.818271
GO:0008289	lipid binding	molecular_function	Clostridium	Clostridium thermocellum	40.434	668.937	426.393	906.92	869.677	781.444
GO:0008289	lipid binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	30.5067	19.9254	17.9561	26.1985	31.6671	27.2967
GO:0008289	lipid binding	molecular_function	Escherichia	Escherichia coli	0.0827067	0	0.535728	0	0	0.0247716
GO:0008295	spermidine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	22.3671	181.953	124.444	740.079	737.444	1042.03
GO:0008295	spermidine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	91.4887	110.189	143.464	72.4909	93.239	81.7297
GO:0008295	spermidine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.167066	0	0.267075	0	0	0.095238
GO:0008296	3'-5'-exodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.00811755	0	0.0450612	0	0	0
GO:0008299	isoprenoid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.97119	17.9604	12.1521	59.794	56.8354	54.8149
GO:0008299	isoprenoid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.215067	0	0	0	0	0.077581
GO:0008299	isoprenoid biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.235579	0.688436	0	0.872668	0.602039	0.417689
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0008312	7S RNA binding	molecular_function	Clostridium	Clostridium thermocellum	1.75473	21.6171	14.4992	36.0885	39.4842	42.3414
GO:0008312	7S RNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.3594	11.5885	11.5127	5.29587	7.73811	5.73753
GO:0008312	7S RNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.08797	0.475044	0.533924	0.674801	0.769651	0.246778
GO:0008320	protein transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.621406	0	0	0	0	0
GO:0008324	cation transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	2.51355	11.0644	11.4866	62.5828	36.163	32.0477
GO:0008324	cation transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	191.391	89.6278	118.539	97.2818	101.387	65.8208
GO:0008324	cation transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.360235	0	0.176185	0	0	0.0675236
GO:0008324	cation transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.902944	1.72487	1.54724	2.82278	1.64912	2.01235
GO:0008360	regulation of cell shape	biological_process	Clostridium	Clostridium thermocellum	66.5047	419.356	357.738	1009.31	942.865	1047.15
GO:0008360	regulation of cell shape	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	296.192	270.097	213.356	254.444	272.511	206.652
GO:0008360	regulation of cell shape	biological_process	Escherichia	Escherichia coli	1.72031	0	0.985844	0	0	0.506007
GO:0008375	acetylglucosaminyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0383855	0	0	0
GO:0008381	mechanically-gated ion channel activity	molecular_function	Escherichia	Escherichia coli	0.132797	0	0	0	0	0
GO:0008408	3'-5' exonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	9.81626	53.0587	43.1783	144.084	132.052	151.627
GO:0008408	3'-5' exonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	136.446	79.7879	109.482	47.9617	57.4811	46.6896
GO:0008408	3'-5' exonuclease activity	molecular_function	Escherichia	Escherichia coli	0.434289	0	0.223006	0	0	0.0194033
GO:0008408	3'-5' exonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.315248	0.770955	0.677046	0.442539	0.114136	0.433632
GO:0008409	5'-3' exonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	3.33376	18.9304	15.4808	44.8822	39.9729	46.566
GO:0008409	5'-3' exonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.232128	0	0.32251	0.475343	0.103718	0.0772576
GO:0008410	CoA-transferase activity	molecular_function	Escherichia	Escherichia coli	0.0227486	0	0	0	0	0
GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.100838	0	0.0623821	0	0	0
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	0.296388	0.189728	1.64873	2.62815	3.08639	2.23481
GO:0008417	fucosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.13061	0	0	0	0	0.069561
GO:0008422	beta-glucosidase activity	molecular_function	Clostridium	Clostridium thermocellum	44.539	159.011	199.836	380.011	390.901	329.343
GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.106654
GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	4.64815	30.4238	25.0534	76.7492	71.5545	67.4362
GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.060906	0	0	0	0	0
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	molecular_function	Clostridium	Clostridium thermocellum	1.20035	4.47483	3.62673	11.2753	13.3918	13.4697
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	92.503	36.1405	61.5543	21.013	24.3019	21.5417
GO:0008452	RNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	0.910041	7.48463	3.94117	18.5528	19.1552	20.1523
GO:0008452	RNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	28.137	19.8382	24.1651	17.1563	18.6719	10.7006
GO:0008452	RNA ligase activity	molecular_function	Escherichia	Escherichia coli	0.090241	0	0.33505	0	0	0
GO:0008452	RNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.184541	0.389771	0.136988	0.264345	0.23068	0.392303
GO:0008453	alanine-glyoxylate transaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	20.0107	25.3463	31.8029	33.1498	38.9397	22.471
GO:0008460	dTDP-glucose 4,6-dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	0	0	0	0.118854	0.285068	0.0772576
GO:0008460	dTDP-glucose 4,6-dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0794256	0	0.0963923	0	0	0.0691405
GO:0008460	dTDP-glucose 4,6-dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0845295	0	0.209564	0.0577733	0.20162	0.0749939
GO:0008470	isovaleryl-CoA dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.065864	0	0.0611642	0	0	0
GO:0008474	palmitoyl-(protein) hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.17567	0	0	0	0	0
GO:0008478	pyridoxal kinase activity	molecular_function	Escherichia	Escherichia coli	0.0681243	0	0	0	0	0
GO:0008479	queuine tRNA-ribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.897136	7.70357	5.64186	27.2274	27.742	24.7672
GO:0008479	queuine tRNA-ribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.0316	1.57836	2.19519	2.15738	2.01841	1.60763
GO:0008479	queuine tRNA-ribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.247999	0.158737	0.153407	0.26335	0.0738116	0.12748
GO:0008483	transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	34.6064	1503.8	1284.56	797.63	836.735	918.54
GO:0008483	transaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	249.643	136.399	206.923	106.815	124.342	88.9495
GO:0008483	transaminase activity	molecular_function	Escherichia	Escherichia coli	0.369106	0	0.207895	0	0	0
GO:0008483	transaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.517312	0.776229	0.879484	1.80773	1.4873	2.24962
GO:0008484	sulfuric ester hydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	1.70218	21.2246	14.8931	44.8457	44.6346	62.6851
GO:0008484	sulfuric ester hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.736097	0	0.334238	0	0	0.0433018
GO:0008495	protoheme IX farnesyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0657425	0	0.122238	0	0	0
GO:0008519	ammonium transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.11158	0.342864	0.248536	0.228308	0.199298	0.239211
GO:0008531	riboflavin kinase activity	molecular_function	Clostridium	Clostridium thermocellum	2.18476	13.2453	14.3414	40.3507	33.9304	35.5191
GO:0008531	riboflavin kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.502	12.0994	6.78476	11.8856	12.0771	13.8432
GO:0008531	riboflavin kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.204106	0.338159	0	0.295319
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.658737	8.53306	5.56125	17.9834	10.9944	24.9227
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.110365	0	0	0	0	0
GO:0008551	cadmium-exporting ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.8413	1.36716	1.77033	2.1443	2.67512	1.34029
GO:0008551	cadmium-exporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0008556	potassium-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.835325	0	0	0.0340529
GO:0008559	xenobiotic-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.090168	0	0	0	0	0.0396151
GO:0008565	protein transporter activity	molecular_function	Clostridium	Clostridium thermocellum	2.81725	12.3044	8.49569	126.483	156.54	148.163
GO:0008565	protein transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	12.0461	16.6253	20.4181	8.68141	8.19072	6.27339
GO:0008565	protein transporter activity	molecular_function	Escherichia	Escherichia coli	0.39132	0	0.265406	0	0	0.0639663
GO:0008565	protein transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.408308	0.58146	0.431532	1.25395	0.553511	0.26201
GO:0008609	alkylglycerone-phosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0372581	0	0	0	0	0.0495755
GO:0008610	lipid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0372581	0	0.150204	0	0	0.0495755
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.125603	0	0	0.28919	0	0.0417172
GO:0008615	pyridoxine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.64329	43.1918	35.0846	91.5843	88.7933	75.3085
GO:0008615	pyridoxine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.07375	7.12706	5.74208	2.3601	3.26514	4.11351
GO:0008615	pyridoxine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.055875	0	0.0959863	0	0	0.0555582
GO:0008616	queuosine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	7.43787	63.0593	46.9281	191.288	179.866	167.202
GO:0008616	queuosine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.62479	5.68111	3.72944	3.46988	3.9781	3.72444
GO:0008616	queuosine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.3204	0	0.311279	0	0	0.12389
GO:0008616	queuosine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.247999	0.158737	0.153407	0.26335	0.0738116	0.12748
GO:0008641	small protein activating enzyme activity	molecular_function	Clostridium	Clostridium thermocellum	1.55531	48.6527	40.5622	116.804	106.304	101.53
GO:0008641	small protein activating enzyme activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	42.592	60.7525	50.0251	65.998	73.718	62.6854
GO:0008641	small protein activating enzyme activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.240634	0.231034	0.669649	0.246239	0	0
GO:0008643	carbohydrate transport	biological_process	Clostridium	Clostridium thermocellum	59.5931	306.415	198.873	1042.01	736.089	800.478
GO:0008643	carbohydrate transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	247.088	84.209	155.228	50.5251	51.841	56.4278
GO:0008643	carbohydrate transport	biological_process	Escherichia	Escherichia coli	1.56265	0	0.920305	0	0	0.784186
GO:0008649	rRNA methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.07106	19.5737	15.6598	64.815	59.9783	50.433
GO:0008649	rRNA methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0375012	0	0	0	0	0
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.375871	0	0	0
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.099914	0	0.185252	0.307047	0	0.0665534
GO:0008652	cellular amino acid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.1678	11.7328	6.25914	43.8577	36.175	34.6783
GO:0008652	cellular amino acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0209987	0	0	0	0	0
GO:0008653	lipopolysaccharide metabolic process	biological_process	Escherichia	Escherichia coli	0.304749	0	0	0	0	0
GO:0008654	phospholipid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	23.5476	153.037	92.8648	476.971	429.473	359.52
GO:0008654	phospholipid biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	355.944	176.926	137.19	170.544	199.138	168.935
GO:0008654	phospholipid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.368887	0	0.399642	0	0	0
GO:0008654	phospholipid biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.29671	4.30961	4.19859	5.05565	3.42999	6.04643
GO:0008657	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity	molecular_function	Escherichia	Escherichia coli	0.150029	0	0	0	0	0.673716
GO:0008658	penicillin binding	molecular_function	Clostridium	Clostridium thermocellum	5.79754	27.9027	26.0004	75.947	69.6038	70.5358
GO:0008658	penicillin binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.5565	11.6189	6.88066	7.818	8.36936	10.2223
GO:0008658	penicillin binding	molecular_function	Escherichia	Escherichia coli	0.164563	0	0.121562	0	0	0
GO:0008661	1-deoxy-D-xylulose-5-phosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	11.4118	55.3911	37.2861	156.799	140.842	119.082
GO:0008661	1-deoxy-D-xylulose-5-phosphate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	58.509	41.4332	32.2915	34.7667	42.3967	30.6407
GO:0008662	1-phosphofructokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	58.606	34.7227	47.5948	14.0036	17.6034	15.7465
GO:0008663	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.36858	2.4759	1.09947	1.97859	2.67567	2.66498
GO:0008663	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.161661	0	0	0
GO:0008664	2'-5'-RNA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.05304	14.8595	15.0335	28.6236	25.8995	31.0351
GO:0008664	2'-5'-RNA ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.57913	6.22052	4.92814	6.42321	4.33271	8.69916
GO:0008664	2'-5'-RNA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.718792	0.460995	0.222735	0.429706	0	0
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0814186	0	0	0	0	0
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	molecular_function	Escherichia	Escherichia coli	0.039008	0	0.144836	0	0	0
GO:0008671	2-dehydro-3-deoxygalactonokinase activity	molecular_function	Escherichia	Escherichia coli	0.112528	0	0	0	0	0
GO:0008672	2-dehydro-3-deoxyglucarate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.0695339	0	0	0	0	0
GO:0008673	2-dehydro-3-deoxygluconokinase activity	molecular_function	Escherichia	Escherichia coli	0.0623156	0	0.567393	0	0	0
GO:0008674	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.103876	0	0	0	0	0
GO:0008675	2-dehydro-3-deoxy-phosphogluconate aldolase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.183357	0	0	0
GO:0008676	3-deoxy-8-phosphooctulonate synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0639608	0	0	0
GO:0008677	2-dehydropantoate 2-reductase activity	molecular_function	Escherichia	Escherichia coli	0.103171	0	0	0	0	0
GO:0008678	2-deoxy-D-gluconate 3-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	1.43953	0	0	0	0	0
GO:0008679	2-hydroxy-3-oxopropionate reductase activity	molecular_function	Escherichia	Escherichia coli	0.0661313	0	0	0	0	0
GO:0008684	2-oxopent-4-enoate hydratase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.205008	0	0	0
GO:0008685	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.76	21.9113	19.3042	21.3913	29.527	21.6888
GO:0008686	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	2.5136	14.1421	9.7049	36.0382	30.5943	26.5774
GO:0008686	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0900222	0.51845	0.668251	0.41451	0.321312	0.479101
GO:0008691	3-hydroxybutyryl-CoA dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0760717	0	0	0	0	0
GO:0008692	3-hydroxybutyryl-CoA epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0966572	0	0	0	0	0.0158461
GO:0008694	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity	molecular_function	Escherichia	Escherichia coli	0.0361644	0	0	0	0	0.0481203
GO:0008695	3-phenylpropionate dioxygenase activity	molecular_function	Escherichia	Escherichia coli	0.172632	0	0.0765455	0	0	0
GO:0008697	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0656748	0	0	0
GO:0008700	4-hydroxy-2-oxoglutarate aldolase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.183357	0	0	0
GO:0008703	5-amino-6-(5-phosphoribosylamino)uracil reductase activity	molecular_function	Escherichia	Escherichia coli	0.0509413	0	0	0	0	0
GO:0008704	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	37.2074	46.3509	67.3938	29.4897	30.3195	28.1634
GO:0008705	methionine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	1.02847	9.14238	5.55692	33.1248	26.5505	35.1121
GO:0008705	methionine synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.221945	0	0	0	0.24776	0
GO:0008705	methionine synthase activity	molecular_function	Escherichia	Escherichia coli	0.0137561	0	0.0127651	0	0	0.0549114
GO:0008706	6-phospho-beta-glucosidase activity	molecular_function	Escherichia	Escherichia coli	0.239638	0	0	0	0	0
GO:0008709	cholate 7-alpha-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.157247	0	0	0	0	0
GO:0008710	8-amino-7-oxononanoate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0	1.28413	0.221743	0.73342	1.19331	1.39811
GO:0008710	8-amino-7-oxononanoate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	134.433	98.7123	165.423	101.135	109.359	59.248
GO:0008712	ADP-glyceromanno-heptose 6-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.124194	0	0	0	0	0
GO:0008713	ADP-heptose-lipopolysaccharide heptosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.319452	0	0.0976553	0	0	0.0721157
GO:0008716	D-alanine-D-alanine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	5.92112	26.9703	36.235	49.0845	53.315	63.7877
GO:0008716	D-alanine-D-alanine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.6178	7.50381	4.59841	9.97003	7.99564	9.1715
GO:0008716	D-alanine-D-alanine ligase activity	molecular_function	Escherichia	Escherichia coli	0.165875	0	0.153948	0	0	0
GO:0008720	D-lactate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0311578	0	0	0	0	0
GO:0008721	D-serine ammonia-lyase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.8998	8.65483	7.6177	10.4077	13.1879	9.88361
GO:0008725	DNA-3-methyladenine glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.234826	0	0.324811	0	0	0
GO:0008728	GTP diphosphokinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.1728	7.58619	5.60298	8.45164	9.38304	7.76994
GO:0008728	GTP diphosphokinase activity	molecular_function	Escherichia	Escherichia coli	0.0785264	0	0	0	0	0
GO:0008730	L(+)-tartrate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0637981	0	0	0	0	0.0848249
GO:0008730	L(+)-tartrate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.0714767	0.186906	0.092942
GO:0008734	L-aspartate oxidase activity	molecular_function	Clostridium	Clostridium thermocellum	2.029	11.9143	6.784	25.377	25.8602	20.0365
GO:0008734	L-aspartate oxidase activity	molecular_function	Escherichia	Escherichia coli	0.0330049	0	0	0	0	0
GO:0008736	L-fucose isomerase activity	molecular_function	Escherichia	Escherichia coli	0.014947	0	0.0554808	0	0	0
GO:0008740	L-rhamnose isomerase activity	molecular_function	Escherichia	Escherichia coli	0.0437716	0	0	0	0	0
GO:0008742	L-ribulose-phosphate 4-epimerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.26478	1.75824	3.5795	2.61482	2.92358	3.20734
GO:0008743	L-threonine 3-dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	1.04194	14.1858	11.3134	21.2411	23.4366	38.7121
GO:0008743	L-threonine 3-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.377831	0	0.0900323	0	0	0
GO:0008744	L-xylulokinase activity	molecular_function	Escherichia	Escherichia coli	0.0359457	0	0.267842	0	0	0
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	Clostridium	Clostridium thermocellum	7.10339	23.5058	19.0309	126.018	116.203	118.523
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.0948	12.6157	10.4638	7.60829	8.64425	9.36065
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	Escherichia	Escherichia coli	0.0675167	0	0	0	0	0.21583
GO:0008747	N-acetylneuraminate lyase activity	molecular_function	Escherichia	Escherichia coli	0.130659	0	0	0	0	0.0434635
GO:0008748	N-ethylmaleimide reductase activity	molecular_function	Escherichia	Escherichia coli	0.165389	0	0	0	0	0
GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity	molecular_function	Escherichia	Escherichia coli	0.0392267	0	0	0	0	0.0260975
GO:0008752	FMN reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0532988	0.511776	0	0.10908	0.285567	0.0709192
GO:0008756	o-succinylbenzoate-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.114796	0	0	0
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.90585	10.6931	9.83756	42.5034	41.2786	45.8459
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.178708	0	0	0	0	0.0680087
GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	15.7121	94.3411	68.7886	207.11	180.461	207.703
GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.7477	23.8692	17.1089	21.6449	23.5611	21.4403
GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0600067	0	0.0812816	0	0	0
GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity	molecular_function	Clostridium	Clostridium thermocellum	2.92271	22.322	22.6089	55.7991	61.8888	59.941
GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	38.8843	38.8641	37.9197	31.6798	32.5771	32.4612
GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.16483	0	0.767079	0.359498	0.166049	0.219937
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	2.82282	15.6682	16.9749	45.2639	42.9255	46.6343
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.8142	45.5113	19.1255	25.9375	35.8126	29.5353
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0276094	0	0.205279	0	0	0.147174
GO:0008763	UDP-N-acetylmuramate-L-alanine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	0.443573	2.03716	1.14417	4.28102	4.49404	5.82362
GO:0008763	UDP-N-acetylmuramate-L-alanine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.38647	5.06801	2.84211	7.00932	6.40468	4.66566
GO:0008763	UDP-N-acetylmuramate-L-alanine ligase activity	molecular_function	Escherichia	Escherichia coli	0.0732767	0	0	0	0	0
GO:0008764	UDP-N-acetylmuramoylalanine-D-glutamate ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.67047	7.83337	6.48665	14.8667	16.8925	28.5573
GO:0008764	UDP-N-acetylmuramoylalanine-D-glutamate ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	69.0901	51.0666	35.3913	44.1491	44.1554	39.7252
GO:0008764	UDP-N-acetylmuramoylalanine-D-glutamate ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.110825
GO:0008765	UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.8484	6.35919	3.91428	6.04182	7.49536	6.00591
GO:0008766	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.66061	18.9106	21.8839	51.6569	46.4233	52.6138
GO:0008766	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	93.6144	85.4518	89.3883	66.6686	70.5838	51.1285
GO:0008766	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	molecular_function	Escherichia	Escherichia coli	0.0401989	0	0	0	0	0
GO:0008767	UDP-galactopyranose mutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.1574	28.828	18.8548	28.2784	39.0091	28.4669
GO:0008767	UDP-galactopyranose mutase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.189131	0	0	0
GO:0008767	UDP-galactopyranose mutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0489241	0	0	0.0250442	0.0437097	0.130196
GO:0008768	UDP-sugar diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0161622	0	0	0	0	0
GO:0008771	[citrate (pro-3S)-lyase] ligase activity	molecular_function	Escherichia	Escherichia coli	0.080252	0	0.0994144	0	0	0
GO:0008772	[isocitrate dehydrogenase (NADP+)] kinase activity	molecular_function	Escherichia	Escherichia coli	0.0919179	0	0.056834	0	0	0.0409087
GO:0008773	[protein-PII] uridylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0576492	0	0	0	0	0
GO:0008774	acetaldehyde dehydrogenase (acetylating) activity	molecular_function	Clostridium	Clostridium thermocellum	0.658664	16.1959	9.70495	72.5495	65.9282	34.2944
GO:0008774	acetaldehyde dehydrogenase (acetylating) activity	molecular_function	Escherichia	Escherichia coli	0.0192731	0	0	0	0	0
GO:0008775	acetate CoA-transferase activity	molecular_function	Escherichia	Escherichia coli	0.0336125	0	0.211098	0	0	0.24694
GO:0008776	acetate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	4.97497	31.7717	26.5377	74.1942	75.7388	54.5204
GO:0008776	acetate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.0488	43.0591	49.0291	50.1978	48.3386	32.4178
GO:0008776	acetate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0923068	0	0	0	0	0.0613792
GO:0008777	acetylornithine deacetylase activity	molecular_function	Escherichia	Escherichia coli	0.0727663	0	0	0	0	0
GO:0008779	acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0121034	0	0	0	0	0
GO:0008783	agmatinase activity	molecular_function	Clostridium	Clostridium thermocellum	1.78679	13.4693	13.2085	36.5505	39.1243	37.5637
GO:0008783	agmatinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.13654	0.328209	0.126884	0.0699597	0.304774	0.454394
GO:0008784	alanine racemase activity	molecular_function	Clostridium	Clostridium thermocellum	0.852732	8.32088	5.31565	23.5014	22.1396	20.8272
GO:0008784	alanine racemase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.03638	4.11012	2.81549	4.96229	3.96708	5.04632
GO:0008784	alanine racemase activity	molecular_function	Escherichia	Escherichia coli	0.052278	0	0	0	0	0
GO:0008785	alkyl hydroperoxide reductase activity	molecular_function	Clostridium	Clostridium thermocellum	16.7778	159.381	159.13	520.725	417.94	348.992
GO:0008785	alkyl hydroperoxide reductase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0636902	0	0	0
GO:0008786	allose 6-phosphate isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.300724	0	0	0
GO:0008787	allose kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.404198	0	0	0
GO:0008791	arginine N-succinyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0549272	0	0	0	0	0
GO:0008792	arginine decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	2.07724	22.2313	19.2719	50.6028	48.4844	63.904
GO:0008792	arginine decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	29.0916	43.415	37.4389	30.963	30.8548	24.9635
GO:0008792	arginine decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0495317	0	0.0493915	0	0	0
GO:0008792	arginine decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.305059	0.147408	0	0	0
GO:0008793	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0698499	0	0	0	0	0
GO:0008794	arsenate reductase (glutaredoxin) activity	molecular_function	Escherichia	Escherichia coli	0.231472	0	0	0	0	0
GO:0008795	NAD+ synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.32506	8.8734	6.57136	6.87448	8.45912	10.685
GO:0008795	NAD+ synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0720129	0.276494	0.801901	0.294711	0.160819	0.670579
GO:0008798	beta-aspartyl-peptidase activity	molecular_function	Clostridium	Clostridium thermocellum	0	0.136474	0.219803	1.1145	0.99395	1.70167
GO:0008798	beta-aspartyl-peptidase activity	molecular_function	Escherichia	Escherichia coli	0.0596421	0	0.0552553	0	0	0
GO:0008800	beta-lactamase activity	molecular_function	Clostridium	Clostridium thermocellum	133936	95932	83193.2	37667.8	49698.2	17083.2
GO:0008800	beta-lactamase activity	molecular_function	Escherichia	Escherichia coli	77927.8	0	34222.8	0	0	7845.05
GO:0008801	beta-phosphoglucomutase activity	molecular_function	Escherichia	Escherichia coli	0.0476602	0	0	0	0	0
GO:0008802	betaine-aldehyde dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0319598	0	0.162338	0	0	0
GO:0008803	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity	molecular_function	Escherichia	Escherichia coli	0.0695339	0	0	0	0	0
GO:0008804	carbamate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	82.2044	17.393	23.6271	27.2268	30.7455	22.1183
GO:0008804	carbamate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0008806	carboxymethylenebutenolidase activity	molecular_function	Escherichia	Escherichia coli	0.0732524	0	0	0	0	0
GO:0008808	cardiolipin synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.139359	3.14249	2.90972	4.88365	5.64617	5.83995
GO:0008808	cardiolipin synthase activity	molecular_function	Escherichia	Escherichia coli	0.0368206	0	0.0826348	0	0	0.0296224
GO:0008810	cellulase activity	molecular_function	Clostridium	Clostridium thermocellum	277.868	290.699	258.98	1025.09	852.867	885.348
GO:0008810	cellulase activity	molecular_function	Escherichia	Escherichia coli	0.0761932	0	0	0	0	0
GO:0008812	choline dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0319598	0	0.088634	0	0	0
GO:0008814	citrate CoA-transferase activity	molecular_function	Escherichia	Escherichia coli	0.0351437	0	0	0	0	0
GO:0008815	citrate (pro-3S)-lyase activity	molecular_function	Escherichia	Escherichia coli	0.0351437	0	0	0	0	0
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.65144	22.8684	15.9601	71.1048	63.2645	77.3703
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.8117	26.9325	13.3741	32.1034	34.5025	26.5592
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.330535	0	0	0	0	0
GO:0008818	cobalamin 5'-phosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.529245	6.25324	3.85109	14.4517	14.1	18.0306
GO:0008818	cobalamin 5'-phosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.151602	0	0	0
GO:0008818	cobalamin 5'-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.225532	0.165809	0.0723358	0.215506
GO:0008821	crossover junction endodeoxyribonuclease activity	molecular_function	Clostridium	Clostridium thermocellum	0.500809	2.89171	0.791977	5.86776	6.65663	10.6703
GO:0008821	crossover junction endodeoxyribonuclease activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	115.224	247.569	243.498	105.74	109.677	88.587
GO:0008821	crossover junction endodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.0633364	0	0	0	0	0
GO:0008821	crossover junction endodeoxyribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0.0750921	0.247328
GO:0008825	cyclopropane-fatty-acyl-phospholipid synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0903029	0	0	0
GO:0008827	cytochrome o ubiquinol oxidase activity	molecular_function	Escherichia	Escherichia coli	0.104532	0	0	0	0	0
GO:0008829	dCTP deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.44795	10.3579	10.2479	25.2983	25.9347	35.8891
GO:0008829	dCTP deaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.83	23.6456	13.4701	22.3517	31.1397	20.7496
GO:0008829	dCTP deaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.107302	0	0	0.219603	0.04792	0
GO:0008830	dTDP-4-dehydrorhamnose 3,5-epimerase activity	molecular_function	Clostridium	Clostridium thermocellum	2.41757	17.5311	19.2926	47.297	40.3979	54.0843
GO:0008830	dTDP-4-dehydrorhamnose 3,5-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.118993	0	0	0	0	0
GO:0008830	dTDP-4-dehydrorhamnose 3,5-epimerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0595692	0	0.330043	0	0	0.312879
GO:0008831	dTDP-4-dehydrorhamnose reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0700929	0	0	0.14355	0.187904	0.139995
GO:0008832	dGTPase activity	molecular_function	Clostridium	Clostridium thermocellum	1.23528	7.17098	4.74217	16.84	15.7692	21.3615
GO:0008832	dGTPase activity	molecular_function	Escherichia	Escherichia coli	0.0861822	0	0.159947	0	0	0
GO:0008833	deoxyribonuclease IV (phage-T4-induced) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.4279	2.54521	2.80124	1.05492	2.42825	2.98876
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	molecular_function	Escherichia	Escherichia coli	0.0797416	0	0	0	0	0
GO:0008835	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	molecular_function	Escherichia	Escherichia coli	0.0509413	0	0	0	0	0
GO:0008836	diaminopimelate decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.417568	12.3454	10.6147	52.5189	52.3375	69.821
GO:0008836	diaminopimelate decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0436744	0	0.0810561	0	0	0
GO:0008836	diaminopimelate decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0641141	0.533619	0.476052	0.459326	0.152658	0.312749
GO:0008837	diaminopimelate epimerase activity	molecular_function	Clostridium	Clostridium thermocellum	0.631128	23.7695	32.1361	39.4224	43.0437	78.4114
GO:0008837	diaminopimelate epimerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.13365	0	0	0
GO:0008837	diaminopimelate epimerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.236284	0.324102	0.560717	0.897886	0.361419	0.314399
GO:0008838	diaminopropionate ammonia-lyase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0918816	0	0	0
GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	molecular_function	Clostridium	Clostridium thermocellum	4.06544	9.76006	8.49578	22.5395	26.214	33.86
GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	molecular_function	Escherichia	Escherichia coli	0.103973	0	0.0439787	0	0	0
GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.642405	1.07298	1.22283	1.0671	0.516638	1.49693
GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	molecular_function	Clostridium	Clostridium thermocellum	1.79903	4.86288	6.05792	20.2576	20.471800000000002	16.4978
GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.6663	32.0953	53.8209	19.8541	22.3277	22.2371
GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.346211	0.332316	0.835099	0.602106	0.247326	0.690662
GO:0008847	Enterobacter ribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.0369908	0	0	0	0	0
GO:0008849	enterochelin esterase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0307219
GO:0008852	exodeoxyribonuclease I activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0008853	exodeoxyribonuclease III activity	molecular_function	Clostridium	Clostridium thermocellum	2.72687	31.9533	20.168	68.6812	56.3785	96.8593
GO:0008853	exodeoxyribonuclease III activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.194748	0.448673	1.29956	0.356762	0.347919	0.206807
GO:0008854	exodeoxyribonuclease V activity	molecular_function	Clostridium	Clostridium thermocellum	1.90991	12.3852	7.99226	25.3602	28.2005	32.8534
GO:0008854	exodeoxyribonuclease V activity	molecular_function	Escherichia	Escherichia coli	0.0591804	0	0	0	0	0
GO:0008855	exodeoxyribonuclease VII activity	molecular_function	Clostridium	Clostridium thermocellum	9.96534	32.9928	26.8289	117.871	107.577	100.856
GO:0008859	exoribonuclease II activity	molecular_function	Clostridium	Clostridium thermocellum	4.55329	15.0492	17.6433	32.604	34.212	38.5598
GO:0008859	exoribonuclease II activity	molecular_function	Escherichia	Escherichia coli	0.0211931	0	0	0	0	0
GO:0008860	ferredoxin-NAD+ reductase activity	molecular_function	Clostridium	Clostridium thermocellum	0.693711	18.2606	26.7851	56.2473	59.6931	111.807
GO:0008860	ferredoxin-NAD+ reductase activity	molecular_function	Escherichia	Escherichia coli	0.0230889	0	0	0	0	0
GO:0008861	formate C-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	6.52107	50.7032	43.4059	122.485	102.544	118.133
GO:0008861	formate C-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	12.2128	10.0403	11.7339	5.33922	5.87136	5.90738
GO:0008861	formate C-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0675653	0	0.0817327	0	0	0.206969
GO:0008863	formate dehydrogenase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.173677	0	0.122734	0	0	0.0263239
GO:0008863	formate dehydrogenase (NAD+) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.180019	0.0992815	0	0
GO:0008866	fructuronate reductase activity	molecular_function	Escherichia	Escherichia coli	0.0554375	0	0	0	0	0
GO:0008867	galactarate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0335639	0	0	0	0	0
GO:0008868	galactitol-1-phosphate 5-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.07577
GO:0008872	glucarate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0507469	0	0	0	0	0
GO:0008878	glucose-1-phosphate adenylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.41814	12.5801	8.53354	55.3722	59.9012	52.6519
GO:0008878	glucose-1-phosphate adenylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	55.6787	29.383	28.2237	27.0182	27.6617	26.7756
GO:0008878	glucose-1-phosphate adenylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0636037	0	0.0787106	0	0	0
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.26015	1.99964	4.92832	0.722029	1.58891	1.92271
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.231618	0	0.12314	0	0	0.0961435
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0667146	0.0640362	0.185613	0.102117	0	0
GO:0008880	glucuronate isomerase activity	molecular_function	Escherichia	Escherichia coli	0.057309	0	0.0705914	0	0	0
GO:0008881	glutamate racemase activity	molecular_function	Clostridium	Clostridium thermocellum	5.7221	25.3437	28.2647	44.3002	51.8337	49.9638
GO:0008881	glutamate racemase activity	molecular_function	Escherichia	Escherichia coli	0.0760717	0	0	0	0	0.101221
GO:0008883	glutamyl-tRNA reductase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0574548	5.29461	5.06386	11.608	7.87258	5.57901
GO:0008883	glutamyl-tRNA reductase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.162654	0	0	0
GO:0008883	glutamyl-tRNA reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321275	1.10178	1.5743	0.867768	0.204941	0.518942
GO:0008884	glutathionylspermidine amidase activity	molecular_function	Escherichia	Escherichia coli	0.0852829	0	0	0	0	0
GO:0008885	glutathionylspermidine synthase activity	molecular_function	Escherichia	Escherichia coli	0.0852829	0	0	0	0	0
GO:0008887	glycerate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	42.8886	9.93042	11.9993	14.1016	15.5978	11.3916
GO:0008887	glycerate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0976051	0	0	0	0	0.129873
GO:0008888	glycerol dehydrogenase [NAD+] activity	molecular_function	Escherichia	Escherichia coli	0.0508684	0	0	0	0	0
GO:0008889	glycerophosphodiester phosphodiesterase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.9157	25.4133	31.2513	18.283	20.8246	13.5499
GO:0008889	glycerophosphodiester phosphodiesterase activity	molecular_function	Escherichia	Escherichia coli	0.0262241	0	0	0	0	0
GO:0008890	glycine C-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	134.433	98.7123	165.423	101.135	109.359	59.248
GO:0008890	glycine C-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0696311	0	0	0	0	0
GO:0008891	glycolate oxidase activity	molecular_function	Escherichia	Escherichia coli	0.0359943	0	0.0668025	0	0	0
GO:0008894	guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.254877	0	0.0675693	0	0	0.0484437
GO:0008897	holo-[acyl-carrier-protein] synthase activity	molecular_function	Clostridium	Clostridium thermocellum	3.1134	23.8982	26.3249	55.7143	50.028	67.7148
GO:0008897	holo-[acyl-carrier-protein] synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7.96412	13.1862	9.17571	10.6701	11.5054	8.74583
GO:0008897	holo-[acyl-carrier-protein] synthase activity	molecular_function	Escherichia	Escherichia coli	0.278913	0	0.0729821	0	0	0.147659
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0137561	0	0.0127651	0	0	0.0549114
GO:0008899	homoserine O-succinyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.80171	18.6499	14.2566	39.4573	34.2343	40.4424
GO:0008899	homoserine O-succinyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.155789	0	0.346913	0	0	0
GO:0008901	ferredoxin hydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	7.39113	47.3819	28.6591	262.74	233.096	198.697
GO:0008901	ferredoxin hydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	72.8251	71.6263	56.2895	66.987	100.712	65.7144
GO:0008901	ferredoxin hydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0312793	0	0.0465498	0	0	0
GO:0008901	ferredoxin hydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	8.38981	7.17588	26.2628	12.3054	11.6651	29.7389
GO:0008908	isochorismatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.127425	0	0	0
GO:0008909	isochorismate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0236965	0	0	0	0	0
GO:0008911	lactaldehyde dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0389594	0	0	0	0	0
GO:0008911	lactaldehyde dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.0740646	0	0	0
GO:0008914	leucyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.704623	2.19613	0.980296	6.0269	4.87048	7.72586
GO:0008914	leucyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0872759	0	0	0	0	0
GO:0008917	lipopolysaccharide N-acetylglucosaminyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.157831	0	0.0976553	0	0	0
GO:0008918	lipopolysaccharide 3-alpha-galactosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.671715	0	0.259948	0	0	0.372512
GO:0008919	lipopolysaccharide glucosyltransferase I activity	molecular_function	Escherichia	Escherichia coli	0.591877	0	0.208121	0	0	0.22385
GO:0008921	lipopolysaccharide-1,6-galactosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.365509	0	0.407987	0	0	0.181033
GO:0008922	long-chain fatty acid [acyl-carrier-protein] ligase activity	molecular_function	Escherichia	Escherichia coli	0.0121034	0	0	0	0	0
GO:0008923	lysine decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.815595	7.43865	3.57716	26.3429	23.4271	26.2391
GO:0008923	lysine decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0486567	0	0.0225983	0	0	0
GO:0008925	maltose O-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.120913	0	0	0	0	0
GO:0008926	mannitol-1-phosphate 5-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0243284	0	0.225757	0	0	0
GO:0008929	methylglyoxal synthase activity	molecular_function	Clostridium	Clostridium thermocellum	14.5058	68.6207	67.2482	226.88	198.339	202.822
GO:0008929	methylglyoxal synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.8476	8.17008	7.28098	5.97475	7.36417	4.43159
GO:0008932	lytic endotransglycosylase activity	molecular_function	Escherichia	Escherichia coli	0.0509413	0	0	0	0	0
GO:0008933	lytic transglycosylase activity	molecular_function	Clostridium	Clostridium thermocellum	3.37987	22.2586	12.6333	61.629	55.6229	67.9723
GO:0008933	lytic transglycosylase activity	molecular_function	Escherichia	Escherichia coli	0.314033	0	0	0	0	0.0656156
GO:0008934	inositol monophosphate 1-phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	37.3761	42.5571	34.4422	32.5891	40.4493	39.8263
GO:0008934	inositol monophosphate 1-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.27587	0	0	0
GO:0008934	inositol monophosphate 1-phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.06735	0.260354	0.0717752	0.156587	0
GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.42921	3.60526	1.94088	5.81473	5.79509	6.63769
GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.052278	0	0.0484893	0	0	0
GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.13061	0.250917	0.0970238	0.080231	0.140114	0.312943
GO:0008940	nitrate reductase activity	molecular_function	Escherichia	Escherichia coli	0.176593	0	0	0	0	0
GO:0008941	nitric oxide dioxygenase activity	molecular_function	Escherichia	Escherichia coli	0.0466881	0	0	0	0	0
GO:0008942	nitrite reductase [NAD(P)H] activity	molecular_function	Escherichia	Escherichia coli	0.0812241	0	0	0	0	0
GO:0008948	oxaloacetate decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	8.12293	37.4354	30.9941	110.292	106.89	100.995
GO:0008948	oxaloacetate decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	80.9923	54.3957	54.9056	41.5088	43.4297	35.3704
GO:0008948	oxaloacetate decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0541008	0	0	0	0	0
GO:0008948	oxaloacetate decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0312307	0.149776	0.115788	0.159741	0.0975763	0.228442
GO:0008949	oxalyl-CoA decarboxylase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0418465
GO:0008955	peptidoglycan glycosyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.22279	6.72394	4.65502	17.615	16.7616	17.2018
GO:0008955	peptidoglycan glycosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0705061	0	0.0375285	0	0	0
GO:0008959	phosphate acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.82636	26.167	24.122	49.8	56.3004	73.964
GO:0008959	phosphate acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0227	0	0	0	0	0
GO:0008960	phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0907756	0	0	0	0	0
GO:0008961	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.97208	5.6224	2.38586	18.0107	13.9535	12.5643
GO:0008961	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	45.9846	64.7185	78.0134	26.6446	31.0394	36.6187
GO:0008961	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity	molecular_function	Escherichia	Escherichia coli	0.0669577	0	0	0	0	0
GO:0008962	phosphatidylglycerophosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0008962	phosphatidylglycerophosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.359773	0.138901	0.335591	0.147927	0.0322939	0
GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	molecular_function	Clostridium	Clostridium thermocellum	8.31155	50.4013	54.5091	143.257	142.31	148.974
GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	123.001	63.0804	56.0024	53.3677	45.8565	36.7708
GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	molecular_function	Escherichia	Escherichia coli	0.0765578	0	0.0472715	0	0	0
GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.16816	0.439805	0.10618	0.28924	0.0766981	0.257062
GO:0008964	phosphoenolpyruvate carboxylase activity	molecular_function	Escherichia	Escherichia coli	0.0194432	0	0	0	0	0.025483
GO:0008964	phosphoenolpyruvate carboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0342444	0.262166	0	0.262877	0.15294	0.159528
GO:0008965	phosphoenolpyruvate-protein phosphotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.6681	14.503	13.2736	20.8846	25.1986	16.0168
GO:0008965	phosphoenolpyruvate-protein phosphotransferase activity	molecular_function	Escherichia	Escherichia coli	0.251839	0	0.0430315	0	0	0.0308513
GO:0008966	phosphoglucosamine mutase activity	molecular_function	Clostridium	Clostridium thermocellum	5.04163	23.9885	14.9549	76.3643	62.9168	59.3693
GO:0008966	phosphoglucosamine mutase activity	molecular_function	Escherichia	Escherichia coli	0.0409037	0	0	0	0	0.0543617
GO:0008966	phosphoglucosamine mutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.280226	0.384217	0.372578	0.553659	0.249866	0.132719
GO:0008967	phosphoglycolate phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	0.916311	12.1999	8.4127	33.9792	34.1312	43.0966
GO:0008967	phosphoglycolate phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.188405	0.361814	0.262248	0.240991	0.0420603	0.125346
GO:0008972	phosphomethylpyrimidine kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0	0.146088	0	0	0	0
GO:0008972	phosphomethylpyrimidine kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.305059	0.147408	0.243752	0.0708166	0.105683
GO:0008973	phosphopentomutase activity	molecular_function	Clostridium	Clostridium thermocellum	0.81263	4.4486	5.05268	10.4408	12.9069	10.716
GO:0008973	phosphopentomutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.6687	10.4423	9.26466	12.7706	15.3251	11.6857
GO:0008973	phosphopentomutase activity	molecular_function	Escherichia	Escherichia coli	0.180458	0	0	0	0	0.060215
GO:0008977	prephenate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	3.38371	16.3874	12.5114	61.2005	62.8299	58.0045
GO:0008977	prephenate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.2427	0.544541	0.41349	0.496905	0.289343	0.565963
GO:0008979	prophage integrase activity	molecular_function	Escherichia	Escherichia coli	0.0479276	0	0	0	0	0
GO:0008980	propionate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0457159	0	0	0	0	0
GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1256.29	552.953	731.412	428.284	475.558	378.832
GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	Escherichia	Escherichia coli	1.17274	0	2.2513	0	0	0.339235
GO:0008983	protein-glutamate O-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.35053	3.84595	4.45073	48.6816	37.6826	26.3392
GO:0008983	protein-glutamate O-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0395184	0.151783	0	0.0403642	0.0705779	0
GO:0008984	protein-glutamate methylesterase activity	molecular_function	Clostridium	Clostridium thermocellum	3.25315	9.02579	9.47242	86.7788	82.4587	83.4675
GO:0008984	protein-glutamate methylesterase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.8894	20.1219	28.0721	10.4345	16.3788	14.0895
GO:0008986	pyruvate, water dikinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.607431	0.574832	0.355077	0.495985	0.352955	0.322516
GO:0008987	quinolinate synthetase A activity	molecular_function	Clostridium	Clostridium thermocellum	3.74812	39.4446	33.242	88.3542	86.2584	79.0776
GO:0008987	quinolinate synthetase A activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0953205	0.122005	0	0.390386	0.0567314	0
GO:0008989	rRNA (guanine-N1-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.151123	0	0	0	0	0
GO:0008993	rhamnulokinase activity	molecular_function	Escherichia	Escherichia coli	0.0552431	0	0	0	0	0
GO:0008998	ribonucleoside-triphosphate reductase activity	molecular_function	Escherichia	Escherichia coli	0.0487782	0	0	0	0	0.0325329
GO:0008998	ribonucleoside-triphosphate reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0891473	0.213999	0.268834	0.0912236	0.059683	0.0889643
GO:0008999	ribosomal-protein-alanine N-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7.87636	3.88773	3.60458	1.22769	3.346	1.58729
GO:0009001	serine O-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.70935	12.2732	6.72188	25.6384	18.8175	41.6856
GO:0009002	serine-type D-Ala-D-Ala carboxypeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	11.4678	41.1042	43.0798	77.3469	76.4782	95.1614
GO:0009002	serine-type D-Ala-D-Ala carboxypeptidase activity	molecular_function	Escherichia	Escherichia coli	0.129832	0	0.380833	0	0	0
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	Clostridium	Clostridium thermocellum	1.16504	22.054	19.0003	37.3825	34.1225	33.9458
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.791777	1.45729	1.46866	0.560821	0.434579	0.4054
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	Escherichia	Escherichia coli	0.331775	0	0.071268	0	0	0
GO:0009010	sorbitol-6-phosphate 2-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0770925	0	0	0	0	0
GO:0009011	starch synthase activity	molecular_function	Clostridium	Clostridium thermocellum	3.25983	22.9129	16.1641	176.137	163.855	141.991
GO:0009011	starch synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	25.1303	18.9059	16.8647	23.5169	27.9081	19.338
GO:0009011	starch synthase activity	molecular_function	Escherichia	Escherichia coli	0.0567743	0	0	0	0	0
GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	molecular_function	Escherichia	Escherichia coli	0.0781861	0	0	0	0	0
GO:0009014	succinyl-diaminopimelate desuccinylase activity	molecular_function	Escherichia	Escherichia coli	0.0496046	0	0	0	0	0
GO:0009017	succinylglutamate desuccinylase activity	molecular_function	Escherichia	Escherichia coli	0.118701	0	0	0	0	0
GO:0009018	sucrose phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.165946	0	0	0
GO:0009022	tRNA nucleotidyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.09874	22.0906	19.5707	49.8565	44.7456	41.7264
GO:0009022	tRNA nucleotidyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.171465	0	0	0	0	0
GO:0009024	tagatose-6-phosphate kinase activity	molecular_function	Clostridium	Clostridium thermocellum	9.86686	28.7165	21.6438	133.033	107.045	143.081
GO:0009024	tagatose-6-phosphate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	125.074	105.814	111.725	74.0842	99.1241	73.0471
GO:0009025	tagatose-bisphosphate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.103414	0	0	0	0	0
GO:0009026	tagaturonate reductase activity	molecular_function	Escherichia	Escherichia coli	0.037331	0	0	0	0	0.0489934
GO:0009027	tartrate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0963923	0	0	0
GO:0009028	tartronate-semialdehyde synthase activity	molecular_function	Escherichia	Escherichia coli	0.0297725	0	0.225667	0	0	0.0197914
GO:0009030	thiamine-phosphate kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.732208	0.75966	1.07344	1.04805	0.508174	0.872342
GO:0009032	thymidine phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0414384	0	0	0	0	0
GO:0009033	trimethylamine-N-oxide reductase activity	molecular_function	Escherichia	Escherichia coli	0.023818	0	0	0	0	0
GO:0009034	tryptophanase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	7.95642	2.92195	5.68913	0.332439	0.870287	2.26893
GO:0009034	tryptophanase activity	molecular_function	Escherichia	Escherichia coli	0.0897792	0	0.299687	0	0	0
GO:0009035	Type I site-specific deoxyribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0504309	0.145202	0.0935957	0.0687908	0.0825362	0.0671032
GO:0009036	Type II site-specific deoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0195762	0	0	0
GO:0009037	tyrosine-based site-specific recombinase activity	molecular_function	Clostridium	Clostridium thermocellum	2.79817	18.9956	17.6943	53.5995	57.7881	90.0056
GO:0009037	tyrosine-based site-specific recombinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.2546	16.0043	18.9494	12.4801	8.90857	9.72214
GO:0009037	tyrosine-based site-specific recombinase activity	molecular_function	Escherichia	Escherichia coli	0.128568	0	0	0	0	0
GO:0009037	tyrosine-based site-specific recombinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123683	0.356213	0.401717	0.253103	0.386681	0.493718
GO:0009039	urease activity	molecular_function	Clostridium	Clostridium thermocellum	0.0309634	0.628694	1.87584	1.02724	1.13578	2.2221
GO:0009045	xylose isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0769063	0	0	0
GO:0009052	pentose-phosphate shunt, non-oxidative branch	biological_process	Escherichia	Escherichia coli	0.24479	0	0.0933701	0	0	0
GO:0009052	pentose-phosphate shunt, non-oxidative branch	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.366068	1.3183	1.01918	1.49649	0.69458	0.912054
GO:0009055	electron carrier activity	molecular_function	Clostridium	Clostridium thermocellum	155.433	2025.06	1177.37	6036.32	4225.39	7111.34
GO:0009055	electron carrier activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6105.26	15041.1	12849.1	5663.86	6300.71	7716.41
GO:0009055	electron carrier activity	molecular_function	Escherichia	Escherichia coli	1.71973	0	2.40106	0	0	0.239211
GO:0009055	electron carrier activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	3.52377	21.4136	10.7144	9.17578	3.57768	9.9522
GO:0009056	catabolic process	biological_process	Escherichia	Escherichia coli	0.0648918	0	0.0618859	0	0	0
GO:0009058	biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	31.9919	1512.4	1300.19	810.889	863.893	937.324
GO:0009058	biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	161.844	67.3117	111.497	41.4137	45.1148	49.2434
GO:0009058	biosynthetic process	biological_process	Escherichia	Escherichia coli	0.196571	0	0.340192	0	0	0.0869269
GO:0009058	biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.05381	2.9143	3.05997	3.37973	2.29367	5.24294
GO:0009059	macromolecule biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.0777973	0.0373389	0.0360851	0.37815	0.277906	0.129388
GO:0009060	aerobic respiration	biological_process	Escherichia	Escherichia coli	0.19696	0	0	0	0	0.106654
GO:0009061	anaerobic respiration	biological_process	Escherichia	Escherichia coli	0.288319	0	0.605102	0	0	0.0680087
GO:0009063	cellular amino acid catabolic process	biological_process	Escherichia	Escherichia coli	0.139554	0	0.0742451	0	0	0
GO:0009073	aromatic amino acid family biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	33.1477	195.447	144.814	520.522	400.363	612.79
GO:0009073	aromatic amino acid family biosynthetic process	biological_process	Escherichia	Escherichia coli	0.543123	0	0.0854314	0	0	0
GO:0009073	aromatic amino acid family biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.89888	5.53782	3.08843	1.50516	1.32659	2.37442
GO:0009082	branched-chain amino acid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	5.75651	34.0291	23.5696	99.5964	78.3471	48.7481
GO:0009086	methionine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	6.93494	45.9129	36.2113	124.122	135.236	151.264
GO:0009086	methionine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.4237	7.6758	5.06856	6.69897	8.77134	7.19531
GO:0009086	methionine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.273737	0	0.490126	0	0	0.0708545
GO:0009086	methionine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.45451	0.689369	0.753186	0.587432	0.161122	0.562341
GO:0009088	threonine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	5.74762	35.8923	30.8092	120.435	128.656	122.88
GO:0009088	threonine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.274417	0.316447	0.10176	0.224826	0.637198	0.219193
GO:0009088	threonine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0847725	0	0.15476	0	0	0
GO:0009088	threonine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.752016	2.01327	2.17133	2.31757	1.04152	1.82708
GO:0009089	lysine biosynthetic process via diaminopimelate	biological_process	Clostridium	Clostridium thermocellum	12.8175	88.7074	87.6977	259.318	265.568	319.566
GO:0009089	lysine biosynthetic process via diaminopimelate	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.314908	0.47201	0.327066	0.26626	0.890384	0.353917
GO:0009089	lysine biosynthetic process via diaminopimelate	biological_process	Escherichia	Escherichia coli	0.310703	0	0.298198	0	0	0.0822378
GO:0009089	lysine biosynthetic process via diaminopimelate	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.64706	2.75967	4.2727	4.35302	1.59384	3.74378
GO:0009090	homoserine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0825366	0	0.0395132	0	0	0
GO:0009094	L-phenylalanine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.97178	34.7949	21.2976	90.9433	79.4176	122.027
GO:0009094	L-phenylalanine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.14196	0	0	0	0	0
GO:0009094	L-phenylalanine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0861822	0	0	0.176379	0	0
GO:0009097	isoleucine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	21.536	164.346	107.335	479.914	443.671	381.841
GO:0009097	isoleucine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.274417	0.316447	0.10176	0.224826	0.637198	0.219193
GO:0009097	isoleucine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.219757	0	0.115427	0	0	0.0414585
GO:0009097	isoleucine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.988008	2.11641	2.6657	3.91177	1.36168	2.36717
GO:0009098	leucine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	16.6799	114.54	77.5037	335.963	262.374	199.657
GO:0009098	leucine biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.115427	0	0	0.0414585
GO:0009098	leucine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.557462	2.28337	1.26343	1.79316	0.668537	0.961662
GO:0009099	valine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	17.2058	142.842	87.5369	416.188	367.883	307.213
GO:0009099	valine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.219757	0	0.115427	0	0	0.0414585
GO:0009099	valine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.403982	1.70643	1.47989	2.6718	1.09014	1.55311
GO:0009102	biotin biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.202428	2.11296	0.97538	2.63837	3.71452	4.66925
GO:0009102	biotin biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	134.433	98.7123	165.423	101.135	109.359	59.248
GO:0009102	biotin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.302124	0	0.233516	0	0	0.11836
GO:0009103	lipopolysaccharide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	10.1563	81.3977	65.9993	190.168	201.5	250.541
GO:0009103	lipopolysaccharide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.0894	14.1176	12.1005	34.4997	35.4584	19.8786
GO:0009103	lipopolysaccharide biosynthetic process	biological_process	Escherichia	Escherichia coli	1.57053	0	1.7029	0	0	0.431368
GO:0009103	lipopolysaccharide biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0845295	0	0.209564	0.0577733	0.20162	0.0749939
GO:0009107	lipoate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.341083	0	0	0	0	0
GO:0009108	coenzyme biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.771678	0.763254	0.841504	1.98225	0.998638	1.40351
GO:0009113	purine nucleobase biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.5272	5.59043	3.38983	57.058	45.3974	35.3047
GO:0009113	purine nucleobase biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.387868	0.299551	0.499508	0.272179	0.405172	0.441555
GO:0009113	purine nucleobase biosynthetic process	biological_process	Escherichia	Escherichia coli	0.220292	0	0	0	0	0
GO:0009113	purine nucleobase biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.213633	0.190708	0.804382	0.622524	0.299956	0.630899
GO:0009114	hypoxanthine catabolic process	biological_process	Escherichia	Escherichia coli	0.0226271	0	0	0	0	0.060215
GO:0009115	xanthine catabolic process	biological_process	Escherichia	Escherichia coli	0.0258109	0	0	0	0	0.0119007
GO:0009116	nucleoside metabolic process	biological_process	Clostridium	Clostridium thermocellum	8.27283	59.0624	42.3816	175.58	174.184	202.063
GO:0009116	nucleoside metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	174.28	112.929	122.558	104.879	119.324	108.393
GO:0009116	nucleoside metabolic process	biological_process	Escherichia	Escherichia coli	0.0710651	0	0	0	0	0
GO:0009116	nucleoside metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.659466	1.10458	1.90245	2.14612	0.396208	1.96278
GO:0009117	nucleotide metabolic process	biological_process	Escherichia	Escherichia coli	0.208966	0	0	0	0	0
GO:0009117	nucleotide metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321445	0.20471	0	0.656919	0.523974	0.141838
GO:0009143	nucleoside triphosphate catabolic process	biological_process	Clostridium	Clostridium thermocellum	4.42378	27.4467	20.7349	59.5457	61.5965	71.5612
GO:0009143	nucleoside triphosphate catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	39.9694	79.6803	76.3232	58.9659	71.4159	58.7156
GO:0009143	nucleoside triphosphate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.235117	0.564237	1.08797	0.960733	0.471539	1.87452
GO:0009152	purine ribonucleotide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.56609	19.096	13.0901	53.6147	49.7911	53.0492
GO:0009156	ribonucleoside monophosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	7.68042	47.456	38.0977	129.847	130.084	128.96
GO:0009156	ribonucleoside monophosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.0708	16.0209	9.62597	23.7424	27.9475	19.6547
GO:0009156	ribonucleoside monophosphate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0685617	0.395372	0.191116	0.56194	0.0306445	0.548177
GO:0009163	nucleoside biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.42921	3.60526	1.94088	5.81473	5.79509	6.63769
GO:0009163	nucleoside biosynthetic process	biological_process	Escherichia	Escherichia coli	0.052278	0	0.0484893	0	0	0
GO:0009165	nucleotide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	12.3477	82.2144	59.9908	225.673	228.045	198.386
GO:0009165	nucleotide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.0708	16.0209	9.62597	23.7424	27.9475	19.6547
GO:0009165	nucleotide biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0685617	0.395372	0.191116	0.56194	0.0306445	0.548177
GO:0009166	nucleotide catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	311.041	63.3319	114.365	50.766	59.364	46.9924
GO:0009166	nucleotide catabolic process	biological_process	Escherichia	Escherichia coli	0.0953934	0	0.161661	0	0	0.105683
GO:0009166	nucleotide catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0388622	0.111877	0	0.0397673	0	0.155097
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.028533	0	0	0	0	0
GO:0009186	deoxyribonucleoside diphosphate metabolic process	biological_process	Escherichia	Escherichia coli	0.0600067	0	0.0919719	0	0	0.0329857
GO:0009220	pyrimidine ribonucleotide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.44795	10.3579	10.2479	25.2983	25.9347	35.8891
GO:0009220	pyrimidine ribonucleotide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.83	23.6456	13.4701	22.3517	31.1397	20.7496
GO:0009220	pyrimidine ribonucleotide biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.107302	0	0	0.219603	0.04792	0
GO:0009225	nucleotide-sugar metabolic process	biological_process	Clostridium	Clostridium thermocellum	0	0	0	0.118854	0.285068	0.0772576
GO:0009225	nucleotide-sugar metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0963923	0	0	0.0691405
GO:0009228	thiamine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	6.01661	51.0999	62.497	93.3511	94.9705	85.8493
GO:0009228	thiamine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	58.6956	41.7458	32.4765	34.8417	42.3967	30.9067
GO:0009228	thiamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.100108	0	0.0458281	0	0	0
GO:0009228	thiamine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.11872	1.98694	1.88175	2.89438	1.18973	1.82805
GO:0009229	thiamine diphosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.19829	31.4616	52.9087	44.9853	47.9843	41.0127
GO:0009229	thiamine diphosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.71622	3.38575	2.93453	2.60064	2.69027	2.62158
GO:0009229	thiamine diphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.100108	0	0.0458281	0	0	0
GO:0009229	thiamine diphosphate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.652126	1.2621	1.20249	1.87076	0.781305	1.10428
GO:0009231	riboflavin biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	13.9733	108.373	64.8526	319.996	247.155	217.613
GO:0009231	riboflavin biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.502	12.0994	6.78476	11.8856	12.0771	13.8432
GO:0009231	riboflavin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.165851	0	0.131891	0	0	0
GO:0009231	riboflavin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.22342	2.71318	3.34955	4.06472	0.854639	3.84729
GO:0009234	menaquinone biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.114796	0	0	0.106654
GO:0009236	cobalamin biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	5.23905	72.1388	49.4712	181.5	165.378	210.436
GO:0009236	cobalamin biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	19.8117	26.9325	13.3741	32.1034	34.5025	26.5592
GO:0009236	cobalamin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.429914	0	0.287553	0	0	0
GO:0009236	cobalamin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.02844	3.50664	3.96489	3.89456	2.84171	5.37637
GO:0009239	enterobactin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.256505	0	0.463062	0	0	0
GO:0009242	colanic acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.504479	0	0	0	0	0
GO:0009243	O antigen biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.26015	1.99964	4.92832	0.722029	1.58891	1.92271
GO:0009243	O antigen biosynthetic process	biological_process	Escherichia	Escherichia coli	0.546404	0	0.349033	0	0	0.0691405
GO:0009243	O antigen biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.151244	0.0640362	0.395177	0.15989	0.20162	0.0749939
GO:0009244	lipopolysaccharide core region biosynthetic process	biological_process	Escherichia	Escherichia coli	3.56912	0	2.71062	0	0	0.606904
GO:0009245	lipid A biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	8.27278	53.4787	39.6463	149.361	140.346	156.965
GO:0009245	lipid A biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.0894	14.1176	12.1005	34.4997	35.4584	19.8786
GO:0009245	lipid A biosynthetic process	biological_process	Escherichia	Escherichia coli	0.51092	0	0.476594	0	0	0.0872827
GO:0009246	enterobacterial common antigen biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.60829	38.8424	31.8566	98.9275	100.38	84.5695
GO:0009246	enterobacterial common antigen biosynthetic process	biological_process	Escherichia	Escherichia coli	0.630083	0	0.729189	0	0	0.069561
GO:0009246	enterobacterial common antigen biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.411541	1.18523	1.3379	0.63185	0.398466	0.410963
GO:0009247	glycolipid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.04611	24.743	19.4994	37.4554	36.2616	38.6475
GO:0009249	protein lipoylation	biological_process	Clostridium	Clostridium thermocellum	1.97208	5.6224	2.38586	18.0107	13.9535	12.5643
GO:0009249	protein lipoylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	79.0831	107.454	114.033	57.2569	68.2734	75.6252
GO:0009249	protein lipoylation	biological_process	Escherichia	Escherichia coli	0.156275	0	0	0	0	0
GO:0009250	glucan biosynthetic process	biological_process	Escherichia	Escherichia coli	0.282267	0	0.209203	0	0	0.0477969
GO:0009252	peptidoglycan biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	51.5267	297.611	267.757	727.587	659.583	717.691
GO:0009252	peptidoglycan biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	260.398	247.371	193.464	222.784	238.3	185.998
GO:0009252	peptidoglycan biosynthetic process	biological_process	Escherichia	Escherichia coli	1.38905	0	0.960495	0	0	0.476222
GO:0009253	peptidoglycan catabolic process	biological_process	Clostridium	Clostridium thermocellum	7.10339	23.5058	19.0309	126.018	116.203	118.523
GO:0009253	peptidoglycan catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.0948	12.6157	10.4638	7.60829	8.64425	9.36065
GO:0009253	peptidoglycan catabolic process	biological_process	Escherichia	Escherichia coli	0.212782	0	0	0	0	0.312523
GO:0009254	peptidoglycan turnover	biological_process	Clostridium	Clostridium thermocellum	1.35245	3.64138	2.19357	9.87297	8.4925	11.1669
GO:0009254	peptidoglycan turnover	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	29.3339	38.3753	20.3505	25.8515	35.8054	29.1819
GO:0009254	peptidoglycan turnover	biological_process	Escherichia	Escherichia coli	0.46987	0	0.0737038	0	0	0.199693
GO:0009263	deoxyribonucleotide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0600067	0	0	0	0	0
GO:0009264	deoxyribonucleotide catabolic process	biological_process	Clostridium	Clostridium thermocellum	2.90613	26.5489	20.1626	70.8073	50.647	71.5258
GO:0009264	deoxyribonucleotide catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	33.9091	24.7874	17.0391	25.9841	31.4897	28.5441
GO:0009264	deoxyribonucleotide catabolic process	biological_process	Escherichia	Escherichia coli	0.0771654	0	0	0	0	0.060215
GO:0009264	deoxyribonucleotide catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.370175	0.347438	0.257738	0.142033	0.0826881	0.18514
GO:0009266	response to temperature stimulus	biological_process	Escherichia	Escherichia coli	0.280031	0	0.374338	0	0	0.123535
GO:0009267	cellular response to starvation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	2264.11	440.619	906.906	318.673	321.72	232.447
GO:0009267	cellular response to starvation	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.324003
GO:0009268	response to pH	biological_process	Escherichia	Escherichia coli	0.613604	0	1.6706	0	0	0.175277
GO:0009271	phage shock	biological_process	Escherichia	Escherichia coli	0.0802034	0	0	0	0	0
GO:0009273	peptidoglycan-based cell wall biogenesis	biological_process	Escherichia	Escherichia coli	0.10949	0	0	0	0	0
GO:0009290	DNA import into cell involved in transformation	biological_process	Escherichia	Escherichia coli	0.201602	0	0.187552	0	0	0
GO:0009294	DNA mediated transformation	biological_process	Clostridium	Clostridium thermocellum	0.857374	9.97961	8.14846	21.3218	22.7481	23.4977
GO:0009294	DNA mediated transformation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.5961	1.49617	2.16822	1.03557	0.590536	0.569488
GO:0009294	DNA mediated transformation	biological_process	Escherichia	Escherichia coli	0.111434	0	0	0	0	0
GO:0009297	pilus assembly	biological_process	Escherichia	Escherichia coli	0.242579	0	0.136672	0	0	0.267701
GO:0009298	GDP-mannose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.03981	0	0	0	0	0
GO:0009305	protein biotinylation	biological_process	Escherichia	Escherichia coli	0.178999	0	0	0	0	0
GO:0009306	protein secretion	biological_process	Clostridium	Clostridium thermocellum	116.884	557.649	443.588	1997.09	1670.65	2125.64
GO:0009306	protein secretion	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	759.094	460.013	447.271	370.495	410.122	328.987
GO:0009306	protein secretion	biological_process	Escherichia	Escherichia coli	1.266	0	0.393824	0	0	0.117681
GO:0009307	DNA restriction-modification system	biological_process	Escherichia	Escherichia coli	0	0	0.14213	0	0	0
GO:0009307	DNA restriction-modification system	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0504309	2.26862	0.680068	0.43274	0.435274	0.803427
GO:0009308	amine metabolic process	biological_process	Escherichia	Escherichia coli	0.0686346	0	0	0	0	0
GO:0009372	quorum sensing	biological_process	Clostridium	Clostridium thermocellum	13.8842	61.0926	57.1465	116.659	97.5631	177.173
GO:0009372	quorum sensing	biological_process	Escherichia	Escherichia coli	0.16534	0	0.492967	0	0	0
GO:0009378	four-way junction helicase activity	molecular_function	Clostridium	Clostridium thermocellum	1.22587	14.6422	11.6968	34.7141	38.6659	39.8676
GO:0009378	four-way junction helicase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.1839	32.6019	22.1902	27.65	26.8396	13.5117
GO:0009378	four-way junction helicase activity	molecular_function	Escherichia	Escherichia coli	0.112917	0	0.104737	0	0	0
GO:0009381	excinuclease ABC activity	molecular_function	Clostridium	Clostridium thermocellum	9.64752	26.388	25.182	61.711	59.6319	57.0161
GO:0009381	excinuclease ABC activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	23.0826	22.3576	15.9566	24.5116	23.5278	18.7787
GO:0009381	excinuclease ABC activity	molecular_function	Escherichia	Escherichia coli	0.111604	0	0	0	0	0
GO:0009381	excinuclease ABC activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.230475	0.140161	0.308573	0.217042	0.168263	0.332023
GO:0009389	dimethyl sulfoxide reductase activity	molecular_function	Escherichia	Escherichia coli	0.102199	0	0.252686	0	0	0
GO:0009395	phospholipid catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0009396	folic acid-containing compound biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	10.5117	54.8254	42.4318	143.959	133.887	149.189
GO:0009396	folic acid-containing compound biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	138.25	57.6078	89.4148	49.3146	66.0765	56.4692
GO:0009396	folic acid-containing compound biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0648918	0	0	0	0	0
GO:0009398	FMN biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.18476	13.2453	14.3414	40.3507	33.9304	35.5191
GO:0009398	FMN biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.502	12.0994	6.78476	11.8856	12.0771	13.8432
GO:0009398	FMN biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.204106	0.338159	0	0.295319
GO:0009399	nitrogen fixation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	89.8945	66.5803	94.2909	35.8416	41.9936	38.8995
GO:0009399	nitrogen fixation	biological_process	Escherichia	Escherichia coli	0.316439	0	0.0358144	0	0	0
GO:0009399	nitrogen fixation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.18881	1.30317	1.201	2.57595	1.33749	3.28104
GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1540.98	667.246	890.113	537.755	597.365	456.607
GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	Escherichia	Escherichia coli	2.54014	0	3.19935	0	0	0.533462
GO:0009403	toxin biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.60246	18.8217	6.64475	57.9102	57.4213	67.5969
GO:0009405	pathogenesis	biological_process	Clostridium	Clostridium thermocellum	29.8344	141.85	161.68	252.317	242.793	327.098
GO:0009405	pathogenesis	biological_process	Escherichia	Escherichia coli	1.34907	0	0.67231	0	0	0.273199
GO:0009407	toxin catabolic process	biological_process	Escherichia	Escherichia coli	0.050601	0	0	0	0	0
GO:0009408	response to heat	biological_process	Clostridium	Clostridium thermocellum	2.69197	26.4416	31.0869	38.6303	41.4569	45.3407
GO:0009408	response to heat	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	106.328	24.3363	42.4334	17.9339	28.2875	32.3251
GO:0009408	response to heat	biological_process	Escherichia	Escherichia coli	0.496532	0	0	0	0	0.267022
GO:0009408	response to heat	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.049556	0.190288	0.458416	0.202692	0.13267	0.395472
GO:0009411	response to UV	biological_process	Clostridium	Clostridium thermocellum	0.208553	0.972351	0.331306	3.19807	3.98802	2.61492
GO:0009411	response to UV	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.175277
GO:0009423	chorismate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	28.9614	161.878	112.064	469.11	355.165	557.325
GO:0009423	chorismate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.543123	0	0	0	0	0
GO:0009423	chorismate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.6265	4.61047	2.46768	1.32797	0.950349	1.73249
GO:0009432	SOS response	biological_process	Clostridium	Clostridium thermocellum	26.7801	153.199	114.421	313.661	317.219	320.542
GO:0009432	SOS response	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	116.093	153.077	177.261	105.008	112.728	92.5415
GO:0009432	SOS response	biological_process	Escherichia	Escherichia coli	2.01267	0	0.768973	0	0	0.36585
GO:0009432	SOS response	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.230475	0.140161	0.308573	0.217042	0.168263	0.332023
GO:0009435	NAD biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	12.187	89.5575	75.878	198.921	190.362	190.331
GO:0009435	NAD biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	199.535	124.645	146.6	98.1614	113.467	78.0325
GO:0009435	NAD biosynthetic process	biological_process	Escherichia	Escherichia coli	0.144488	0	0	0	0	0.0614116
GO:0009435	NAD biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.308224	0.904721	2.07534	1.47793	0.924696	2.21819
GO:0009436	glyoxylate catabolic process	biological_process	Escherichia	Escherichia coli	0.0297725	0	0.225667	0	0	0.0197914
GO:0009437	carnitine metabolic process	biological_process	Escherichia	Escherichia coli	0.988494	0	0.590893	0	0	0.130229
GO:0009438	methylglyoxal metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0997753	0	0	0.170588
GO:0009443	pyridoxal 5'-phosphate salvage	biological_process	Escherichia	Escherichia coli	0.0681243	0	0	0	0	0
GO:0009446	putrescine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0266129	0	0.0493915	0	0	0
GO:0009447	putrescine catabolic process	biological_process	Escherichia	Escherichia coli	0.0785507	0	0	0	0	0.0828522
GO:0009450	gamma-aminobutyric acid catabolic process	biological_process	Escherichia	Escherichia coli	0.099865399999999993	0	0.079748	0	0	0
GO:0009451	RNA modification	biological_process	Clostridium	Clostridium thermocellum	2.68205	21.4866	17.6564	50.7099	42.5184	45.7352
GO:0009451	RNA modification	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.5997	11.3454	7.56375	15.5999	16.5164	19.1874
GO:0009451	RNA modification	biological_process	Escherichia	Escherichia coli	0.133697	0	0	0	0	0
GO:0009451	RNA modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.124479	0.240552	0.0442191	0	0.229186
GO:0009605	response to external stimulus	biological_process	Escherichia	Escherichia coli	0.270674	0	0	0	0	0.126833
GO:0009607	response to biotic stimulus	biological_process	Escherichia	Escherichia coli	0.114108	0	0	0	0	0
GO:0009617	response to bacterium	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0009636	response to toxic substance	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5102.29	13939.3	11938.1	4792.25	5139.37	6668.11
GO:0009636	response to toxic substance	biological_process	Escherichia	Escherichia coli	0.231861	0	0	0	0	0
GO:0009637	response to blue light	biological_process	Escherichia	Escherichia coli	0.0457645	0	0	0	0	0.0304632
GO:0009658	chloroplast organization	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.7965	30.3904	25.2548	30.4867	36.1375	23.6265
GO:0009678	hydrogen-translocating pyrophosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	329.96	76.3616	128.399	27.1477	34.4745	46.8286
GO:0009735	response to cytokinin	biological_process	Clostridium	Clostridium thermocellum	4.49499	69.5112	74.5146	100.37	105.77	104.092
GO:0009735	response to cytokinin	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	50.2588	66.8372	80.2765	34.749	48.1546	40.7722
GO:0009758	carbohydrate utilization	biological_process	Escherichia	Escherichia coli	0.0941296	0	0	0	0	0
GO:0009791	post-embryonic development	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.7965	30.3904	25.2548	30.4867	36.1375	23.6265
GO:0009845	seed germination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	32.7965	30.3904	25.2548	30.4867	36.1375	23.6265
GO:0009847	spore germination	biological_process	Clostridium	Clostridium thermocellum	0.720567	4.40828	4.72669	11.3903	13.797	20.0624
GO:0009882	blue light photoreceptor activity	molecular_function	Escherichia	Escherichia coli	0.0457645	0	0	0	0	0.0304632
GO:0009927	histidine phosphotransfer kinase activity	molecular_function	Escherichia	Escherichia coli	0.0862308	0	0.0824995	0	0	0.0390654
GO:0009970	cellular response to sulfate starvation	biological_process	Escherichia	Escherichia coli	0	0	0.111097	0	0	0
GO:0009982	pseudouridine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	20.2392	92.4515	82.796	183.884	183.662	250.521
GO:0009982	pseudouridine synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	49.0558	37.5712	26.2759	39.8535	39.3993	31.4734
GO:0009982	pseudouridine synthase activity	molecular_function	Escherichia	Escherichia coli	0.292475	0	0	0	0	0
GO:0009982	pseudouridine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.752551	0.87625	0.922425	0.569526	0.745864	0.887056
GO:0009992	cellular water homeostasis	biological_process	Escherichia	Escherichia coli	0.0545626	0	0	0	0	0.0773546
GO:0010033	response to organic substance	biological_process	Escherichia	Escherichia coli	0.098796	0	0.0815072	0	0	0
GO:0010038	response to metal ion	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.444106	0	0
GO:0010041	response to iron(III) ion	biological_process	Escherichia	Escherichia coli	0	0	0.287237	0	0	0.103032
GO:0010043	response to zinc ion	biological_process	Escherichia	Escherichia coli	0.151682	0	0	0	0	0
GO:0010045	response to nickel cation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.535151	0.341931	0.68724	0.364397	1.03378	0.533074
GO:0010124	phenylacetate catabolic process	biological_process	Clostridium	Clostridium thermocellum	7.04363	28.6383	26.3849	80.0477	75.0165	65.8896
GO:0010124	phenylacetate catabolic process	biological_process	Escherichia	Escherichia coli	0.203546	0	0.112495	0	0	0
GO:0010124	phenylacetate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.294541	0.161957	0.702937	0.517149	0.187709	0.47619
GO:0010133	proline catabolic process to glutamate	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	8.8536	7.17812	8.30773	2.55001	3.206	4.34188
GO:0010133	proline catabolic process to glutamate	biological_process	Escherichia	Escherichia coli	0.00636766	0	0	0	0	0
GO:0010181	FMN binding	molecular_function	Clostridium	Clostridium thermocellum	32.9676	282.972	230.348	778.784	706.429	824.017
GO:0010181	FMN binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.39	64.6538	47.2545	48.6192	55.3004	43.0751
GO:0010181	FMN binding	molecular_function	Escherichia	Escherichia coli	0.890768	0	1.2766	0	0	0.109014
GO:0010181	FMN binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.54802	3.90453	2.76394	3.99064	1.79507	4.1756
GO:0010188	response to microbial phytotoxin	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0010212	response to ionizing radiation	biological_process	Escherichia	Escherichia coli	0.0778216	0	0	0	0	0.0845339
GO:0010285	L,L-diaminopimelate aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.112212	6.54863	14.2787	14.7861	20.8913	21.728
GO:0010285	L,L-diaminopimelate aminotransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0448896	0.129286	0.499643	0.0459351	0.0400853	0.0298488
GO:0010312	detoxification of zinc ion	biological_process	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0010340	carboxyl-O-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0	0.465523	0.128508	0.212515	0.618316	0.2764
GO:0010438	cellular response to sulfur starvation	biological_process	Escherichia	Escherichia coli	0.0481949	0	0.0452868	0	0	0.0217641
GO:0010468	regulation of gene expression	biological_process	Escherichia	Escherichia coli	0.0281198	0	0	0	0	0
GO:0010498	proteasomal protein catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.61894	3.5695	1.70137	1.70878	0.959095	2.58087
GO:0010501	RNA secondary structure unwinding	biological_process	Escherichia	Escherichia coli	0.0880779	0	0.0645923	0	0	0.0529711
GO:0010608	posttranscriptional regulation of gene expression	biological_process	Escherichia	Escherichia coli	0.108493	0	0	0	0	0
GO:0010628	positive regulation of gene expression	biological_process	Escherichia	Escherichia coli	0.0309148	0	0	0	0	0.0822378
GO:0010629	negative regulation of gene expression	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.112378
GO:0010795	regulation of ubiquinone biosynthetic process	biological_process	Escherichia	Escherichia coli	0.130416	0	0.0604876	0	0	0
GO:0010967	regulation of polyamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0983099	0	0.072937	0	0	0
GO:0010974	negative regulation of barrier septum assembly	biological_process	Escherichia	Escherichia coli	0.108615	0	0	0	0	0.144684
GO:0015020	glucuronosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0280226	0	0	0	0	0
GO:0015031	protein transport	biological_process	Clostridium	Clostridium thermocellum	5.68761	59.1771	35.7814	143.815	136.364	129.333
GO:0015031	protein transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	7.12833	14.9748	13.5304	19.2067	19.5046	16.6573
GO:0015031	protein transport	biological_process	Escherichia	Escherichia coli	0.951139	0	2.04494	0	0	0.382925
GO:0015031	protein transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.884445	1.58485	0	0
GO:0015035	protein disulfide oxidoreductase activity	molecular_function	Clostridium	Clostridium thermocellum	69.7436	705.845	554.929	1695.74	1289.88	2098.5
GO:0015035	protein disulfide oxidoreductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	74.529	175.079	237.509	129.362	148.538	101.234
GO:0015035	protein disulfide oxidoreductase activity	molecular_function	Escherichia	Escherichia coli	0.710675	0	0.532526	0	0	0
GO:0015035	protein disulfide oxidoreductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.01528	4.75987	2.86529	2.80575	0.970207	1.94706
GO:0015036	disulfide oxidoreductase activity	molecular_function	Escherichia	Escherichia coli	0.101688	0	0	0	0	0
GO:0015074	DNA integration	biological_process	Clostridium	Clostridium thermocellum	15.0104	115.421	74.3284	140.258	108.481	112.067
GO:0015074	DNA integration	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.85029	12.0532	10.9526	11.5675	15.2489	15.3099
GO:0015074	DNA integration	biological_process	Escherichia	Escherichia coli	2.53836	0	0.64448	0	0	0.316759
GO:0015075	ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	70.4932	19.0135	31.7417	17.3804	35.2874	19.0254
GO:0015075	ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0771654	0	0	0	0	0.102676
GO:0015078	hydrogen ion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	44.9564	683.11	435.448	1010.09	966.511	862.389
GO:0015078	hydrogen ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	201.028	127.136	107.719	156.35	188.081	133.627
GO:0015078	hydrogen ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.501177	0	0	0
GO:0015078	hydrogen ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.557049	0.252084	0.9268	1.05191	0.681059	0.882949
GO:0015079	potassium ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.311481	0	0.0892204	0	0	0.109694
GO:0015079	potassium ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0960739	0.73609	0.266533	0.343382	0.256746	0.766432
GO:0015081	sodium ion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	2.38104	17.75	13.8523	29.105	39.5093	53.9613
GO:0015081	sodium ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	57.6596	26.7981	29.3111	17.74	17.493	12.5063
GO:0015081	sodium ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.207557	0	0.177403	0	0	0
GO:0015087	cobalt ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.24621	1.08189	1.3757	1.00187	0.476835	0.789716
GO:0015087	cobalt ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.714855	0	0.0220119	0	0	0
GO:0015087	cobalt ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0	0.747707
GO:0015091	ferric iron transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0223597	0	0	0	0	0
GO:0015093	ferrous iron transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	0	0	0	0.0248701	0.0976414	0.048476
GO:0015093	ferrous iron transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.08462	5.46879	4.18758	3.62868	3.38264	2.09136
GO:0015093	ferrous iron transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.135349	0	0	0	0	0
GO:0015093	ferrous iron transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.120184	2.76513	1.81531	0.517871	0.273739	0.410607
GO:0015094	lead ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0015095	magnesium ion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	1.51708	7.00716	5.29025	20.5804	20.1047	21.6624
GO:0015095	magnesium ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.24621	1.08189	1.3757	1.00187	0.476835	0.789716
GO:0015095	magnesium ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.691134	0	0	0	0	0
GO:0015098	molybdate ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.436355	0.566151	0	1.2966	0.352889	0.449155
GO:0015099	nickel cation transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.120232	0	0.0220119	0	0	0.0478292
GO:0015103	inorganic anion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.241364	5.40574	5.57221	1.34403	2.56268	2.1735
GO:0015103	inorganic anion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.207727	0	0.192785	0	0	0
GO:0015103	inorganic anion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.295351	0.0951744	0.209879	0	0.136405
GO:0015105	arsenite transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0395583	0	0	0.185755
GO:0015109	chromate transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.238277	0.228794	0.110556	0.121913	0.212775	0
GO:0015112	nitrate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.15331	0	0	0	0	0
GO:0015113	nitrite transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.15331	0	0	0	0	0
GO:0015116	sulfate transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.0751824	0	0
GO:0015128	gluconate transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	210.675	295.704	262.819	84.4667	105.365	123.045
GO:0015128	gluconate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.285791	0	0.0761395	0	0	0.164637
GO:0015129	lactate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.161403	0	0.119757	0	0	0
GO:0015143	urate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0374282	0	0.0694638	0	0	0
GO:0015144	carbohydrate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.525138	0	0.245965	0	0	0.178543
GO:0015145	monosaccharide transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.4668	15.9374	18.6096	2.48895	4.0153	5.36667
GO:0015145	monosaccharide transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.366432	0	0.113984	0	0	0.174565
GO:0015153	rhamnose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0960253	0	0.119351	0	0	0
GO:0015159	polysaccharide transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.147258	0	0.186966	0	0	0
GO:0015169	glycerol-3-phosphate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0724747	0	0	0	0	0
GO:0015171	amino acid transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.37314	0	0.11042	0	0	3.23389
GO:0015173	aromatic amino acid transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.246224	0	0.199641	0	0	0.134886
GO:0015179	L-amino acid transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.460343	0	0.523098	0	0	0.179351
GO:0015181	arginine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0498962	0	0	0	0	0
GO:0015185	gamma-aminobutyric acid transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0388622	0	0	0	0	0
GO:0015188	L-isoleucine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.145411	0	0	0	0	0
GO:0015190	L-leucine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.246832	0	0	0	0	0
GO:0015197	peptide transporter activity	molecular_function	Escherichia	Escherichia coli	0.233756	0	0	0	0	0
GO:0015199	amino-acid betaine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.265619	0	0	0	0	0
GO:0015205	nucleobase transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.186874	0	0	0	0	0
GO:0015207	adenine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.123489	0	0.151873	0	0	0.054588
GO:0015208	guanine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0803249	0	0	0	0	0.0530681
GO:0015210	uracil transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0548468
GO:0015211	purine nucleoside transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.141109	0	0	0	0	0
GO:0015212	cytidine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015213	uridine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015214	pyrimidine nucleoside transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015218	pyrimidine nucleotide transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0548468
GO:0015220	choline transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.265619	0	0	0	0	0
GO:0015221	lipopolysaccharide transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.416332	0	0	0
GO:0015225	biotin transporter activity	molecular_function	Clostridium	Clostridium thermocellum	8.34706	193.014	226.224	269.89	317.035	470.798
GO:0015225	biotin transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.981519	4.00614	2.05031	1.63257	2.30155	3.91462
GO:0015225	biotin transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.150029	0.144035	0.278442	0.230049	0.0669752	0.0997978
GO:0015230	FAD transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0959524	0	0	0	0	0.0780984
GO:0015232	heme transporter activity	molecular_function	Escherichia	Escherichia coli	0.237475	0	0	0	0	0.0756407
GO:0015233	pantothenate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.111993	0	0	0	0	0
GO:0015234	thiamine transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	35.435	13.8448	25.477	9.90637	9.92735	6.56379
GO:0015235	cobalamin transporter activity	molecular_function	Escherichia	Escherichia coli	0.0914562	0	0.0530902	0	0	0.0381599
GO:0015238	drug transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	5.61193	45.0619	27.6101	112.842	109.7	124.834
GO:0015238	drug transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.32465	3.04886	2.80652	8.9609	7.80836	5.64546
GO:0015238	drug transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.824831	0	0.178802	0	0	0.267798
GO:0015238	drug transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.260612	0.0385524	0.149212	0.12343	0.125638	0.133721
GO:0015288	porin activity	molecular_function	Escherichia	Escherichia coli	1.54856	0	0.928875	0	0	0.781017
GO:0015291	secondary active transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0773355	0	0	0	0	0
GO:0015292	uniporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0807855	0	0	0
GO:0015293	symporter activity	molecular_function	Escherichia	Escherichia coli	1.78885	0	0.82071	0	0	0.350036
GO:0015294	solute:cation symporter activity	molecular_function	Escherichia	Escherichia coli	0.36388	0	0	0	0	0.0281348
GO:0015295	solute:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.0392997	0	0	0	0	0.0261298
GO:0015297	antiporter activity	molecular_function	Clostridium	Clostridium thermocellum	5.85329	50.4677	33.1823	114.186	112.263	127.008
GO:0015297	antiporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.32465	3.04886	2.80652	8.9609	7.80836	5.64546
GO:0015297	antiporter activity	molecular_function	Escherichia	Escherichia coli	1.32963	0	0.700502	0	0	0.359447
GO:0015297	antiporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.260612	0.333903	0.244386	0.333309	0.125638	0.270127
GO:0015299	solute:proton antiporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.0469554	0.45096	0.348627	1.0571	1.06906	1.84325
GO:0015299	solute:proton antiporter activity	molecular_function	Escherichia	Escherichia coli	0.239079	0	0	0	0	0.0393888
GO:0015299	solute:proton antiporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.127426	0.06721	0.0324766	0.338035	0.0413441	0.123179
GO:0015307	drug:proton antiporter activity	molecular_function	Escherichia	Escherichia coli	0.265619	0	0	0	0	0
GO:0015315	organophosphate:inorganic phosphate antiporter activity	molecular_function	Escherichia	Escherichia coli	0.0724747	0	0	0	0	0
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	10.2247	261.617	224.053	600.669	529.904	634.346
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	89.9159	78.5431	74.0493	39.0499	46.2699	45.7423
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0655723	0	0	0	0	0
GO:0015333	peptide:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.115323	0	0.253047	0	0	0
GO:0015343	siderophore transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0426293	0	0.117682	0	0	0
GO:0015385	sodium:proton antiporter activity	molecular_function	Escherichia	Escherichia coli	0.151584	0	0.0323864	0	0	0
GO:0015386	potassium:proton antiporter activity	molecular_function	Escherichia	Escherichia coli	0.151584	0	0	0	0	0
GO:0015388	potassium uptake transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0557049	0	0	0	0	0
GO:0015407	monosaccharide-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0354596	0	0	0	0	0
GO:0015412	molybdate transmembrane-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.106914	0	0	0	0	0
GO:0015412	molybdate transmembrane-transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.498786	0.0785896	0	0
GO:0015413	nickel-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0733429	0	0	0
GO:0015415	phosphate ion transmembrane-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	0.52645	0.388931	0.299596	0.331593	0.759667	1.28874
GO:0015415	phosphate ion transmembrane-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.243484	0	0	0
GO:0015415	phosphate ion transmembrane-transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.158851	0.152529	0.442223	0.0812756	0.14185	0.422831
GO:0015419	sulfate transmembrane-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	61.4377	791.322	688.592	1110.28	1083.96	1272.36
GO:0015419	sulfate transmembrane-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.229843	0	0.845654	0	0	0.189053
GO:0015420	cobalamin-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	1.74309	13.8545	11.2913	33.7485	31.6547	41.1753
GO:0015420	cobalamin-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.052278	0	0.0484893	0	0	0
GO:0015420	cobalamin-transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.507371	0.464216	0.893196	0.726431	0.447297	1.43129
GO:0015424	amino acid-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	2.21653	7.02737	4.46553	13.6725	13.1167	12.4513
GO:0015424	amino acid-transporting ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.69913	1.65803	2.58974	0.210327	0.734318	0.547109
GO:0015424	amino acid-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.420971	0	0.0740646	0	0	0.103387
GO:0015430	glycerol-3-phosphate-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0978357	0	0	0
GO:0015439	heme-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.192785	0	0	0
GO:0015444	magnesium-importing ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.101479
GO:0015446	arsenite-transmembrane transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0	0.31359
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	54.6744	346.477	215.63	1371.68	1105.27	1449.86
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	320.77	451.692	397.094	377.988	419.456	341.457
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.162011	0	0.0541727	0	0	0
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.864349	4.36814	2.48701	0.723423	1.07795
GO:0015459	potassium channel regulator activity	molecular_function	Escherichia	Escherichia coli	0.208748	0	0.176185	0	0	0.0427844
GO:0015473	fimbrial usher porin activity	molecular_function	Escherichia	Escherichia coli	0.242579	0	0.136672	0	0	0.203735
GO:0015481	maltose transporting porin activity	molecular_function	Escherichia	Escherichia coli	0.0408065	0	0	0	0	0
GO:0015487	melibiose:monovalent cation symporter activity	molecular_function	Escherichia	Escherichia coli	0.142252	0	0.0880025	0	0	0.212208
GO:0015489	putrescine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0392997	0	0	0	0	0.0261298
GO:0015496	putrescine:ornithine antiporter activity	molecular_function	Escherichia	Escherichia coli	0.103876	0	0	0	0	0
GO:0015499	formate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.139019	0	0	0	0	0
GO:0015501	glutamate:sodium symporter activity	molecular_function	Escherichia	Escherichia coli	0.23327	0	0.0854314	0	0	0.0613145
GO:0015503	glutathione-regulated potassium exporter activity	molecular_function	Escherichia	Escherichia coli	0.132068	0	0	0	0	0.0393888
GO:0015513	nitrite uptake transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.143588	0	0	0	0	0
GO:0015517	galactose:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.0554289
GO:0015518	arabinose:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.0554289
GO:0015527	glycerol-phosphate:inorganic phosphate antiporter activity	molecular_function	Escherichia	Escherichia coli	0.0724747	0	0	0	0	0
GO:0015535	fucose:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.0554289
GO:0015538	sialic acid:proton symporter activity	molecular_function	Escherichia	Escherichia coli	0.0194189	0	0	0	0	0.103387
GO:0015542	sugar efflux transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.117413	0	0	0	0	0.0624787
GO:0015546	sulfathiazole transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0266372	0	0.0494366	0	0	0
GO:0015556	C4-dicarboxylate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.167188	0	0.0759591	0	0	0
GO:0015558	p-aminobenzoyl-glutamate uptake transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0773355	0	0	0	0	0
GO:0015562	efflux transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.177055	0	0	0	0	0.0861185
GO:0015565	threonine efflux transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0443792	0	0	0	0	0
GO:0015568	L-idonate transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.145363	0	0	0	0	0.0552672
GO:0015572	N-acetylglucosamine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0270504	0	0	0	0	0
GO:0015574	trehalose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0383275	0	0	0	0	0.0431401
GO:0015577	galactitol transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.122468	0	0	0	0	0
GO:0015591	D-ribose transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.122857	0	0.0664868	0	0	0.109467
GO:0015592	methylgalactoside transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.142252	0	0.0880025	0	0	0.212208
GO:0015594	putrescine-importing ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	1.49691	24.2779	16.7169	104.586	98.4303	50.9279
GO:0015594	putrescine-importing ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0456927	0	0	0.065745
GO:0015595	spermidine-importing ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	1.49691	24.2779	16.7169	104.586	98.4303	50.9279
GO:0015595	spermidine-importing ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0456927	0	0	0
GO:0015606	spermidine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.251401	0	0	0	0	0
GO:0015612	L-arabinose-importing ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	0.899031	2.69643	3.67495	3.0391	3.53656	4.19044
GO:0015612	L-arabinose-importing ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.518649	1.61411	2.1228	0.219578	0.28739	0.499668
GO:0015612	L-arabinose-importing ATPase activity	molecular_function	Escherichia	Escherichia coli	0.26331	0	0.262158	0	0	0.109467
GO:0015614	D-xylose-importing ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0174503	0	0.0323864	0	0	0
GO:0015616	DNA translocase activity	molecular_function	Escherichia	Escherichia coli	0.0241582	0	0	0	0	0
GO:0015620	ferric-enterobactin transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.053153	0	0.0917012	0	0	0.0327593
GO:0015623	iron-chelate-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.139198	0	0	0
GO:0015628	protein secretion by the type II secretion system	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	12.0461	16.6253	20.4181	8.68141	8.19072	6.27339
GO:0015628	protein secretion by the type II secretion system	biological_process	Escherichia	Escherichia coli	0.239371	0	0.111187	0	0	0
GO:0015643	toxic substance binding	molecular_function	Escherichia	Escherichia coli	0.107934	0	0.406363	0	0	0
GO:0015648	lipid-linked peptidoglycan transporter activity	molecular_function	Escherichia	Escherichia coli	0.0443792	0	0	0	0	0
GO:0015655	alanine:sodium symporter activity	molecular_function	Escherichia	Escherichia coli	0.0759016	0	0.139018	0	0	0
GO:0015658	branched-chain amino acid transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.4622	2.06521	1.51941	1.18974	1.11601	0.516032
GO:0015661	L-lysine efflux transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.129711	0	0	0	0	0
GO:0015675	nickel cation transport	biological_process	Escherichia	Escherichia coli	0.0341229	0	0	0	0	0
GO:0015682	ferric iron transport	biological_process	Escherichia	Escherichia coli	0.0223597	0	0	0	0	0
GO:0015684	ferrous iron transport	biological_process	Escherichia	Escherichia coli	0.329004	0	0.0804246	0	0	0
GO:0015685	ferric-enterobactin transport	biological_process	Escherichia	Escherichia coli	0.053153	0	0.0917012	0	0	0.0327593
GO:0015692	lead ion transport	biological_process	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0015693	magnesium ion transport	biological_process	Clostridium	Clostridium thermocellum	1.51708	7.00716	5.29025	20.5804	20.1047	21.6624
GO:0015693	magnesium ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.24621	1.08189	1.3757	1.00187	0.476835	0.789716
GO:0015693	magnesium ion transport	biological_process	Escherichia	Escherichia coli	0.691134	0	0	0	0	0.101479
GO:0015700	arsenite transport	biological_process	Escherichia	Escherichia coli	0	0	0.0395583	0	0	0.185755
GO:0015707	nitrite transport	biological_process	Escherichia	Escherichia coli	0.143588	0	0	0	0	0
GO:0015716	organic phosphonate transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.112281
GO:0015724	formate transport	biological_process	Escherichia	Escherichia coli	0.139019	0	0	0	0	0
GO:0015726	L-idonate transport	biological_process	Escherichia	Escherichia coli	0.145363	0	0	0	0	0.0552672
GO:0015734	taurine transport	biological_process	Escherichia	Escherichia coli	0	0	0.111097	0	0	0
GO:0015739	sialic acid transport	biological_process	Escherichia	Escherichia coli	0.0194189	0	0	0	0	0.103387
GO:0015747	urate transport	biological_process	Escherichia	Escherichia coli	0.0374282	0	0.0694638	0	0	0
GO:0015749	monosaccharide transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.4668	15.9374	18.6096	2.48895	4.0153	5.36667
GO:0015749	monosaccharide transport	biological_process	Escherichia	Escherichia coli	0.245981	0	0.113984	0	0	0.174565
GO:0015751	arabinose transport	biological_process	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.0554289
GO:0015753	D-xylose transport	biological_process	Escherichia	Escherichia coli	0.115323	0	0	0	0	0
GO:0015756	fucose transport	biological_process	Escherichia	Escherichia coli	0.0410252	0	0	0	0	0.0554289
GO:0015757	galactose transport	biological_process	Escherichia	Escherichia coli	0.333597	0	0.109022	0	0	0.0554289
GO:0015765	methylgalactoside transport	biological_process	Escherichia	Escherichia coli	0.142252	0	0.0880025	0	0	0.212208
GO:0015769	melibiose transport	biological_process	Escherichia	Escherichia coli	0.142252	0	0.0880025	0	0	0.212208
GO:0015771	trehalose transport	biological_process	Escherichia	Escherichia coli	0.0383275	0	0	0	0	0.0431401
GO:0015793	glycerol transport	biological_process	Escherichia	Escherichia coli	0.0724747	0	0	0	0	0
GO:0015794	glycerol-3-phosphate transport	biological_process	Clostridium	Clostridium thermocellum	115.851	297.81	235.253	1285.84	1089.39	861.139
GO:0015794	glycerol-3-phosphate transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	188.38	65.4715	118.616	36.1918	34.5571	42.4546
GO:0015794	glycerol-3-phosphate transport	biological_process	Escherichia	Escherichia coli	0.114108	0	0	0	0	0
GO:0015803	branched-chain amino acid transport	biological_process	Escherichia	Escherichia coli	0.145411	0	0	0	0	0
GO:0015807	L-amino acid transport	biological_process	Escherichia	Escherichia coli	0.707175	0	0.523098	0	0	0.179351
GO:0015809	arginine transport	biological_process	Escherichia	Escherichia coli	0.0835087	0	0.154985	0	0	0
GO:0015814	p-aminobenzoyl-glutamate transport	biological_process	Escherichia	Escherichia coli	0.0773355	0	0	0	0	0
GO:0015818	isoleucine transport	biological_process	Escherichia	Escherichia coli	0.145411	0	0	0	0	0
GO:0015820	leucine transport	biological_process	Escherichia	Escherichia coli	0.246832	0	0	0	0	0
GO:0015823	phenylalanine transport	biological_process	Escherichia	Escherichia coli	0	0	0.0920621	0	0	0.105328
GO:0015829	valine transport	biological_process	Escherichia	Escherichia coli	0.26941	0	0	0	0	0
GO:0015833	peptide transport	biological_process	Clostridium	Clostridium thermocellum	1.79733	15.142	8.86768	34.1038	41.3	34.1558
GO:0015833	peptide transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	488.778	153.393	213.126	105.328	128.007	101.995
GO:0015833	peptide transport	biological_process	Escherichia	Escherichia coli	0.674146	0	0.659049	0	0	0.279279
GO:0015846	polyamine transport	biological_process	Clostridium	Clostridium thermocellum	2.86812	14.2759	7.34115	83.8084	72.8267	32.8495
GO:0015846	polyamine transport	biological_process	Escherichia	Escherichia coli	0	0	0.181102	0	0	0
GO:0015847	putrescine transport	biological_process	Escherichia	Escherichia coli	0.0392997	0	0	0	0	0.0918424
GO:0015851	nucleobase transport	biological_process	Escherichia	Escherichia coli	0.186874	0	0	0	0	0
GO:0015853	adenine transport	biological_process	Escherichia	Escherichia coli	0.123489	0	0.151873	0	0	0.054588
GO:0015857	uracil transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0548468
GO:0015860	purine nucleoside transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015861	cytidine transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015862	uridine transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015864	pyrimidine nucleoside transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0015871	choline transport	biological_process	Escherichia	Escherichia coli	0.265619	0	0	0	0	0
GO:0015886	heme transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0756407
GO:0015887	pantothenate transmembrane transport	biological_process	Escherichia	Escherichia coli	0.111993	0	0	0	0	0
GO:0015889	cobalamin transport	biological_process	Escherichia	Escherichia coli	0.0426293	0	0	0	0	0
GO:0015891	siderophore transport	biological_process	Escherichia	Escherichia coli	0.111726	0	0.135725	0	0	0.0669738
GO:0015906	sulfathiazole transport	biological_process	Escherichia	Escherichia coli	0.0266372	0	0.0494366	0	0	0
GO:0015914	phospholipid transport	biological_process	Escherichia	Escherichia coli	0.110462	0	0	0	0	0
GO:0015920	lipopolysaccharide transport	biological_process	Escherichia	Escherichia coli	0.098796	0	0.497839	0	0	0
GO:0015926	glucosidase activity	molecular_function	Clostridium	Clostridium thermocellum	1.0845	6.84132	6.44917	14.4016	15.454	20.6395
GO:0015926	glucosidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0204783	0	0	0
GO:0015936	coenzyme A metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0465666	0.357427	0	0.0476512	0.12349	0.0309807
GO:0015937	coenzyme A biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	21.973	145.312	118.669	335.267	318.503	312.709
GO:0015937	coenzyme A biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	47.3424	81.1278	64.0564	61.3695	68.0343	58.0248
GO:0015937	coenzyme A biosynthetic process	biological_process	Escherichia	Escherichia coli	0.125117	0	0.681377	0	0	0
GO:0015937	coenzyme A biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.144245	0.589068	0.603343	0.725884	0.123707	0.648653
GO:0015940	pantothenate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	10.5444	43.7854	30.9204	93.2364	91.9091	101.826
GO:0015940	pantothenate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	86.372	51.1001	56.7059	49.8328	52.3983	44.7988
GO:0015940	pantothenate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.210084	0	0	0	0	0
GO:0015941	pantothenate catabolic process	biological_process	Clostridium	Clostridium thermocellum	2.40399	14.0103	9.51189	35.0685	35.422	28.2307
GO:0015941	pantothenate catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.75624	4.16977	2.89714	3.77369	4.86838	3.58089
GO:0015941	pantothenate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.144245	0.461509	0.356881	0.318537	0.0643926	0.383798
GO:0015948	methanogenesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	27.9748	18.0663	28.4618	27.1532	16.1025	27.568
GO:0015949	nucleobase-containing small molecule interconversion	biological_process	Escherichia	Escherichia coli	0.153577	0	0	0	0	0
GO:0015969	guanosine tetraphosphate metabolic process	biological_process	Clostridium	Clostridium thermocellum	2.39942	12.373	7.30416	35.2623	33.6013	30.5255
GO:0015969	guanosine tetraphosphate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.1728	7.58619	5.60298	8.45164	9.38304	7.76994
GO:0015970	guanosine tetraphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.333403	0	0.0675693	0	0	0.0484437
GO:0015974	guanosine pentaphosphate catabolic process	biological_process	Escherichia	Escherichia coli	0.254877	0	0.0675693	0	0	0.0484437
GO:0015976	carbon utilization	biological_process	Clostridium	Clostridium thermocellum	0.658664	16.1959	9.70495	72.5495	65.9282	34.2944
GO:0015976	carbon utilization	biological_process	Escherichia	Escherichia coli	0.208675	0	0.176005	0	0	0.270191
GO:0015977	carbon fixation	biological_process	Escherichia	Escherichia coli	0.0194432	0	0	0	0	0.025483
GO:0015977	carbon fixation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0342444	0.262166	0	0.262877	0.15294	0.159528
GO:0015979	photosynthesis	biological_process	Clostridium	Clostridium thermocellum	4.56945	22.8185	16.9742	52.6723	45.9177	66.2287
GO:0015979	photosynthesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	54.4072	55.9203	43.4377	63.3122	70.553	37.9243
GO:0015979	photosynthesis	biological_process	Escherichia	Escherichia coli	0.585874	0	0.528331	0	0	0.0471824
GO:0015979	photosynthesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.87559	2.37592	2.75528	1.30118	0.823192	1.31645
GO:0015986	ATP synthesis coupled proton transport	biological_process	Clostridium	Clostridium thermocellum	40.434	668.937	426.393	906.92	869.677	781.444
GO:0015986	ATP synthesis coupled proton transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	85.7719	70.0725	52.4691	100.01	132.568	71.7211
GO:0015986	ATP synthesis coupled proton transport	biological_process	Escherichia	Escherichia coli	0	0	0.501177	0	0	0
GO:0015991	ATP hydrolysis coupled proton transport	biological_process	Clostridium	Clostridium thermocellum	54.7493	782.906	507.51	1241.4	1193.76	1037.99
GO:0015991	ATP hydrolysis coupled proton transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	299.031	179.331	150.513	220.231	268.282	203.938
GO:0015991	ATP hydrolysis coupled proton transport	biological_process	Escherichia	Escherichia coli	0.039421200000000003	0	0.501177	0	0	0
GO:0015991	ATP hydrolysis coupled proton transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.747471	0.443213	1.40799	1.46774	1.07041	1.40102
GO:0015992	proton transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	329.96	76.3616	128.399	27.1477	34.4745	46.8286
GO:0015992	proton transport	biological_process	Escherichia	Escherichia coli	0.410666	0	0.222374	0	0	0.190702
GO:0015995	chlorophyll biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.47512	23.5746	18.4798	53.1256	45.2639	66.1155
GO:0015995	chlorophyll biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.989807	1.17071	0.813673	1.09185	0.833826	0.786255
GO:0015995	chlorophyll biosynthetic process	biological_process	Escherichia	Escherichia coli	0.585874	0	0.528331	0	0	0.0471824
GO:0015995	chlorophyll biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.87559	2.37592	2.75528	1.30118	0.823192	1.31645
GO:0016024	CDP-diacylglycerol biosynthetic process	biological_process	Escherichia	Escherichia coli	0.323463	0	0	0	0	0
GO:0016036	cellular response to phosphate starvation	biological_process	Escherichia	Escherichia coli	0.190058	0	0	0	0	0
GO:0016048	detection of temperature stimulus	biological_process	Escherichia	Escherichia coli	0.0815887	0	0	0	0	0
GO:0016051	carbohydrate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.01823	7.02629	4.44239	48.2055	36.3285	39.9526
GO:0016051	carbohydrate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0453757	0.172926	0.0842136	0.742945	0.162121	0.332153
GO:0016052	carbohydrate catabolic process	biological_process	Clostridium	Clostridium thermocellum	2.09353	22.1003	15.1099	60.3665	37.74	60.8098
GO:0016052	carbohydrate catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	91.1103	28.1964	28.6492	23.9455	28.6974	33.1018
GO:0016052	carbohydrate catabolic process	biological_process	Escherichia	Escherichia coli	0.0771654	0	0	0	0	0
GO:0016052	carbohydrate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.370175	0.347438	0.257738	0.142033	0.0826881	0.18514
GO:0016075	rRNA catabolic process	biological_process	Clostridium	Clostridium thermocellum	1.29891	6.48698	2.88541	28.1773	22.2648	16.6507
GO:0016114	terpenoid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	9.35047	70.1949	47.9649	168.702	161.307	170.131
GO:0016114	terpenoid biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	99.108	86.8614	64.7914	79.988	93.7285	68.1825
GO:0016114	terpenoid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.219709	0	0	0	0	0
GO:0016117	carotenoid biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.298381	0.635321	0.0921974	0.101719	0.133147	0.674751
GO:0016149	translation release factor activity, codon specific	molecular_function	Clostridium	Clostridium thermocellum	8.22943	53.8034	38.0568	151.697	156.734	164.242
GO:0016149	translation release factor activity, codon specific	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	100.411	68.8617	64.911	74.1595	79.4663	52.5343
GO:0016149	translation release factor activity, codon specific	molecular_function	Escherichia	Escherichia coli	0.033734	0	0.0626527	0	0	0.0224432
GO:0016149	translation release factor activity, codon specific	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0452541	0.608344	0.251964	0.231566	0.242313	0.330859
GO:0016151	nickel cation binding	molecular_function	Clostridium	Clostridium thermocellum	1.396	40.236	36.0393	83.4331	69.5957	62.1647
GO:0016151	nickel cation binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	78.4407	69.0492	74.2359	84.4078	80.3539	50.0137
GO:0016151	nickel cation binding	molecular_function	Escherichia	Escherichia coli	0.253127	0	0	0	0	0
GO:0016151	nickel cation binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	15.4715	7.40832	19.0774	17.2368	11.5143	11.4617
GO:0016153	urocanate hydratase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	18.4303	10.6455	37.127	1.77538	2.92599	4.555
GO:0016154	pyrimidine-nucleoside phosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	0.738284	1.98489	2.77977	9.99093	9.33907	7.15631
GO:0016154	pyrimidine-nucleoside phosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	30.5868	22.757	25.5162	24.0789	31.9322	18.0353
GO:0016154	pyrimidine-nucleoside phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0414384	0	0	0	0	0
GO:0016162	cellulose 1,4-beta-cellobiosidase activity	molecular_function	Clostridium	Clostridium thermocellum	29.1765	25.9726	18.4872	104.811	91.8518	100.319
GO:0016163	nitrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.545869	1.22402	0.7655	2.16848	0.836213	1.44442
GO:0016197	endosomal transport	biological_process	Clostridium	Clostridium thermocellum	0.844128	1.36483	0.989498	14.7573	12.6659	10.6787
GO:0016197	endosomal transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0151414	0.116311	0.168608	0.123953	0.0946464	0.362616
GO:0016208	AMP binding	molecular_function	Escherichia	Escherichia coli	0.0624857	0	0	0	0	0
GO:0016208	AMP binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321105	0.603863	0.128914	0.461639	0	0.431271
GO:0016209	antioxidant activity	molecular_function	Clostridium	Clostridium thermocellum	6.81943	141.165	105.744	337.12	230.315	488.91
GO:0016209	antioxidant activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	47.8557	15.3999	95.7575	7.71615	13.4677	28.4274
GO:0016226	iron-sulfur cluster assembly	biological_process	Clostridium	Clostridium thermocellum	3.46617	67.6044	65.482	114.777	110.089	136.593
GO:0016226	iron-sulfur cluster assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	63.3322	62.2854	59.1862	6.35001	10.196	9.64194
GO:0016226	iron-sulfur cluster assembly	biological_process	Escherichia	Escherichia coli	0.360016	0	0.157827	0	0	0.0375455
GO:0016226	iron-sulfur cluster assembly	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.381501	1.37897	0.790669	0.528142	0.400766	0.537408
GO:0016259	selenocysteine metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	33.2716	51.5545	66.8396	27.4989	35.3101	21.7446
GO:0016259	selenocysteine metabolic process	biological_process	Escherichia	Escherichia coli	0.0286545	0	0	0	0	0
GO:0016260	selenocysteine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.40476	16.8858	13.3064	39.3101	43.4919	37.9766
GO:0016260	selenocysteine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.9356	17.2239	16.0292	17.8264	20.1536	21.2747
GO:0016260	selenocysteine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0212417	0	0	0	0	0
GO:0016298	lipase activity	molecular_function	Escherichia	Escherichia coli	0.0364075	0	0	0	0	0
GO:0016301	kinase activity	molecular_function	Clostridium	Clostridium thermocellum	45.5243	226.434	179.036	916.407	881.102	1045.35
GO:0016301	kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	515.008	453.921	527.034	323.433	389.687	304.637
GO:0016301	kinase activity	molecular_function	Escherichia	Escherichia coli	2.76884	0	3.57161	0	0	0.494041
GO:0016301	kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	4.29557	4.98269	2.66773	3.33859	2.01507	2.95907
GO:0016310	phosphorylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0016310	phosphorylation	biological_process	Escherichia	Escherichia coli	0.143904	0	0.567393	0	0	0
GO:0016310	phosphorylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0632878	0.187441	0.0587285	0.0645628	0.113029	0.215668
GO:0016311	dephosphorylation	biological_process	Clostridium	Clostridium thermocellum	1.23491	9.13104	5.3175	27.0817	19.7135	23.0007
GO:0016311	dephosphorylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.94741	5.0141	2.59939	7.62938	7.53182	5.54085
GO:0016311	dephosphorylation	biological_process	Escherichia	Escherichia coli	1.52656	0	0.779257	0	0	0.438612
GO:0016311	dephosphorylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.281003	0.744397	0.263782	0.502426	0.109621	0
GO:0016405	CoA-ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.294541	0.161957	0.702937	0.517149	0.187709	0.47619
GO:0016407	acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0333938	0	0.0817327	0	0	0
GO:0016407	acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.039421200000000003	0	0	0	0.0704043	0.0524537
GO:0016410	N-acyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.118215	0	0	0	0	0
GO:0016413	O-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.223276	0	0	0
GO:0016415	octanoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.341083	0	0	0	0	0
GO:0016416	O-palmitoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.118264	0	0	0	0	0
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.611927	4.37182	3.08121	10.9291	8.2845	15.2462
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.495997	0.158597	0.153407	0.169191	0	0
GO:0016430	tRNA (adenine-N6-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.140416	0	0	0
GO:0016434	rRNA (cytosine) methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.129006	0	0	0	0	0
GO:0016437	tRNA cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0223111	0	0	0	0	0
GO:0016437	tRNA cytidylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0016462	pyrophosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	3.92593	27.1335	16.1024	89.4446	80.4397	68.3222
GO:0016462	pyrophosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	51.7973	29.7592	26.6445	20.2701	25.1246	15.1858
GO:0016462	pyrophosphatase activity	molecular_function	Escherichia	Escherichia coli	0.03405	0	0	0	0	0
GO:0016462	pyrophosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.122249	0.356213	0.286922	0.126564	0.193243	0.575956
GO:0016463	zinc-exporting ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.8413	1.36716	1.77033	2.1443	2.67512	1.34029
GO:0016463	zinc-exporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0016485	protein processing	biological_process	Escherichia	Escherichia coli	0.169424	0	0	0	0	0
GO:0016491	oxidoreductase activity	molecular_function	Clostridium	Clostridium thermocellum	84.3911	839.947	654.431	2048.18	1791.14	2380.9
GO:0016491	oxidoreductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6523.31	14984.4	13383.7	5555.74	6228.2	7900.53
GO:0016491	oxidoreductase activity	molecular_function	Escherichia	Escherichia coli	2.47551	0	2.55451	0	0	1.25067
GO:0016491	oxidoreductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	5.66571	16.9487	11.6479	17.644	7.50235	15.0906
GO:0016539	intein-mediated protein splicing	biological_process	Clostridium	Clostridium thermocellum	15.9503	80.7575	104.534	135.659	145.23	149.925
GO:0016539	intein-mediated protein splicing	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.2401	0.477658	0.379705	0.351489	0.309136	0.585237
GO:0016540	protein autoprocessing	biological_process	Escherichia	Escherichia coli	0.0596421	0	0.0552553	0	0	0
GO:0016597	amino acid binding	molecular_function	Clostridium	Clostridium thermocellum	30.9154	201.901	156.513	513.895	466.456	471.19
GO:0016597	amino acid binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	64.8263	25.8324	29.2434	29.6508	33.8493	23.0321
GO:0016597	amino acid binding	molecular_function	Escherichia	Escherichia coli	0.744069	0	0.204467	0	0	0
GO:0016597	amino acid binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.46143	2.34862	2.72848	2.31188	1.65945	3.41712
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	Clostridium	Clostridium thermocellum	0.590661	6.23938	6.73266	15.5823	17.5142	24.8387
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	49.4772	24.604	18.3525	18.578	18.8433	15.6221
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	Escherichia	Escherichia coli	0.410034	0	0.246732	0	0	0.0495755
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0946886	0.363914	0.131891	0.0242484	0.042299	0.0945589
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	Clostridium	Clostridium thermocellum	12.3699	143.819	94.7709	392.804	338.032	274.143
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	111.98	113.11	90.9395	125.413	149.457	106.639
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	2.46764	0	2.04233	0	0	0.170588
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.242554	0.465803	0.540013	0.198563	0.216508	0.516129
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	0.0302342	0	0.112225	0	0	0
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	160.445	10.9993	20.7678	5.23805	5.2151	4.77089
GO:0016625	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	molecular_function	Clostridium	Clostridium thermocellum	5.21115	122.998	88.8388	212.784	207.427	225.863
GO:0016625	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	440.06	99.0689	205.948	63.8164	73.35	55.8581
GO:0016625	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	molecular_function	Escherichia	Escherichia coli	0.0653293	0	0.146596	0	0	0
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	Escherichia	Escherichia coli	0.0368206	0	0	0	0	0
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	molecular_function	Clostridium	Clostridium thermocellum	0.352822	1.59544	1.4264	9.34948	6.41586	5.38808
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	0.130999	0	0.0405055	0	0	0
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.453951	1.49108	0.952646	1.67878	1.15991	2.00246
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	0.0566527	0	0.113894	0	0	0
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123051	0.425617	0.274202	0.100799	0.109795	0.294898
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	molecular_function	Escherichia	Escherichia coli	0.0261755	0	0	0	0	0
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.309196	0.166391	0.522873	0.201	0.2735	0.238855
GO:0016651	oxidoreductase activity, acting on NAD(P)H	molecular_function	Clostridium	Clostridium thermocellum	0.783927	6.16806	3.72998	19.1628	18.519	16.1259
GO:0016651	oxidoreductase activity, acting on NAD(P)H	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	111.537	75.7659	81.9169	105.601	102.045	51.835
GO:0016651	oxidoreductase activity, acting on NAD(P)H	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123683	0.778142	0.427653	0.10331	0.320248	0.0924892
GO:0016652	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0532988	0.511776	0	0.10908	0.285567	0.0709192
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.156229
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0532988	0.511776	0	0.10908	0.285567	0.0709192
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	molecular_function	Escherichia	Escherichia coli	0.0564826	0	0	0	0	0
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	molecular_function	Escherichia	Escherichia coli	0.0206584	0	0	0	0	0
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	molecular_function	Escherichia	Escherichia coli	0.0685131	0	0	0	0	0
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	molecular_function	Escherichia	Escherichia coli	0.0920638	0	0.0646374	0	0	0.023187
GO:0016692	NADH peroxidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	56.6641	72.7031	100.891	75.3205	108.043	91.2171
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	Escherichia	Escherichia coli	0.0551702	0	0	0	0	0
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	6.22434	1.48707	6.3337	6.22444	5.29137	12.8244
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	Escherichia	Escherichia coli	0.0500177	0	0	0	0	0
GO:0016708	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor	molecular_function	Escherichia	Escherichia coli	0.0498476	0	0	0	0	0
GO:0016722	oxidoreductase activity, oxidizing metal ions	molecular_function	Escherichia	Escherichia coli	0.068659	0	0	0	0	0
GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	molecular_function	Clostridium	Clostridium thermocellum	4.06544	9.76006	8.49578	22.5395	26.214	33.86
GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	0.0723289	0	0	0	0	0
GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.361571	0.694877	0.805193	0.923204	0.290624	0.673651
GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.610117	0.416738	0.650205	0.283701	0.422055
GO:0016740	transferase activity	molecular_function	Clostridium	Clostridium thermocellum	48.9152	387.626	291.329	984.594	869.141	909.554
GO:0016740	transferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1378.86	757.897	842.507	602.021	687.286	590.54
GO:0016740	transferase activity	molecular_function	Escherichia	Escherichia coli	1.42774	0	0.600772	0	0	0.310518
GO:0016740	transferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.08045	4.35082	4.08415	6.98756	1.99817	4.74661
GO:0016741	transferase activity, transferring one-carbon groups	molecular_function	Escherichia	Escherichia coli	0.0964628	0	0	0	0	0
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	molecular_function	Escherichia	Escherichia coli	0.0265157	0	0.049211	0	0	0
GO:0016743	carboxyl- or carbamoyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.241607	3.27014	1.08914	9.48984	7.39755	8.80261
GO:0016743	carboxyl- or carbamoyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	5.79985	8.39756	4.91912	6.8849	7.22312	7.9444
GO:0016743	carboxyl- or carbamoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0214706	0	0	0
GO:0016743	carboxyl- or carbamoyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0714782	0.343191	0.442223	0.231615	0.0850971	0.110825
GO:0016744	transferase activity, transferring aldehyde or ketonic groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.149324	0.501741	0.346552	0.076401	0.266447	0.347061
GO:0016746	transferase activity, transferring acyl groups	molecular_function	Clostridium	Clostridium thermocellum	1.00884	3.38855	2.91915	17.8118	14.5481	21.1241
GO:0016746	transferase activity, transferring acyl groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	44.8414	32.6972	30.944	32.8257	38.1974	28.2954
GO:0016746	transferase activity, transferring acyl groups	molecular_function	Escherichia	Escherichia coli	0.368522	0	0	0	0	0.0961435
GO:0016746	transferase activity, transferring acyl groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.134733	0.631801	0.129762	0
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	Clostridium	Clostridium thermocellum	8.12898	55.4573	22.4483	204.23	158.909	103.123
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	80.7218	94.8999	70.5393	108.616	128.233	96.9585
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	Escherichia	Escherichia coli	0.305794	0	0	0	0	0
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.394625	1.23685	0.427383	1.03619	0.517636	1.3117
GO:0016755	transferase activity, transferring amino-acyl groups	molecular_function	Clostridium	Clostridium thermocellum	0.187093	2.10419	0.942452	5.19669	4.29486	4.19435
GO:0016755	transferase activity, transferring amino-acyl groups	molecular_function	Escherichia	Escherichia coli	0.0143151	0	0	0	0	0
GO:0016757	transferase activity, transferring glycosyl groups	molecular_function	Clostridium	Clostridium thermocellum	8.12543	85.9673	76.0786	173.097	167.105	176.538
GO:0016757	transferase activity, transferring glycosyl groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	38.861	37.6813	31.4745	33.9496	44.5723	36.2736
GO:0016757	transferase activity, transferring glycosyl groups	molecular_function	Escherichia	Escherichia coli	1.04247	0	0.476955	0	0	0.281833
GO:0016757	transferase activity, transferring glycosyl groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0867898	0.192855	0.17596	0.823002	0.352586	0.372447
GO:0016758	transferase activity, transferring hexosyl groups	molecular_function	Clostridium	Clostridium thermocellum	2.523	26.836	20.7677	45.9819	45.7431	48.9789
GO:0016758	transferase activity, transferring hexosyl groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	23.0057	10.0247	7.60845	14.6403	15.6966	16.805
GO:0016758	transferase activity, transferring hexosyl groups	molecular_function	Escherichia	Escherichia coli	0.0411225	0	0.11448	0	0	0
GO:0016758	transferase activity, transferring hexosyl groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0861093	0	0	0	0	0
GO:0016760	cellulose synthase (UDP-forming) activity	molecular_function	Escherichia	Escherichia coli	0.0393726	0	0	0	0	0
GO:0016763	transferase activity, transferring pentosyl groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.93853	1.14346	1.69027	0.728719	1.27641	0.422896
GO:0016763	transferase activity, transferring pentosyl groups	molecular_function	Escherichia	Escherichia coli	0.200095	0	0.0586834	0	0	0
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	molecular_function	Clostridium	Clostridium thermocellum	5.18554	58.2138	51.3871	116.81	117.896	126.646
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.46276	2.28943	2.91662	0.637297	0.99204	1.80244
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.391125	0.370962	0.488908	0.55622	0.130803	0.110567
GO:0016772	transferase activity, transferring phosphorus-containing groups	molecular_function	Escherichia	Escherichia coli	0	0	0.287237	0	0	0.103032
GO:0016772	transferase activity, transferring phosphorus-containing groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.187441	0	0	0	0.131458
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular_function	Clostridium	Clostridium thermocellum	3.28428	20.1069	21.7966	37.1672	36.8788	48.0418
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.1265	24.3598	14.7753	15.3747	16.4329	16.4033
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular_function	Escherichia	Escherichia coli	0.618927	0	0.645201	0	0	0.0419435
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.121071	0.350792	0.193539	0.084446	0.0419435
GO:0016774	phosphotransferase activity, carboxyl group as acceptor	molecular_function	Escherichia	Escherichia coli	0.0195648	0	0	0	0	0.0390654
GO:0016774	phosphotransferase activity, carboxyl group as acceptor	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0945671	0.120978	0.117006	0.61285	0	0.209718
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	molecular_function	Clostridium	Clostridium thermocellum	6.59697	103.14	172.408	53.3925	61.8042	46.4737
GO:0016776	phosphotransferase activity, phosphate group as acceptor	molecular_function	Escherichia	Escherichia coli	0.0975565	0	0	0	0	0
GO:0016779	nucleotidyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	14.4557	146.815	108.905	386.373	341.151	378.763
GO:0016779	nucleotidyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	106.424	100.867	102.97	72.0581	93.4425	81.5766
GO:0016779	nucleotidyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.160966	0	0.298739	0	0	0
GO:0016779	nucleotidyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.45973	2.86805	0.948767	1.18951	0.561324	2.79457
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	molecular_function	Escherichia	Escherichia coli	0.28917	0	0.14619	0	0	0
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.121071	0.45377	0.534235	0.431063	0.411124
GO:0016783	sulfurtransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.79967	38.8015	41.6555	95.6325	84.0832	62.1276
GO:0016783	sulfurtransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	47.4728	25.5698	16.3938	7.78537	10.9886	7.01621
GO:0016783	sulfurtransferase activity	molecular_function	Escherichia	Escherichia coli	0.205102	0	0	0	0	0
GO:0016783	sulfurtransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0814186	0.312713	1.0964	0.722328	0.209238	1.2736
GO:0016787	hydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	160.454	821.53	712.615	2056.03	1971.88	2453.43
GO:0016787	hydrolase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	834.065	641.316	665.284	526.99	629.442	544.747
GO:0016787	hydrolase activity	molecular_function	Escherichia	Escherichia coli	1.50445	0	0.276773	0	0	0.343051
GO:0016787	hydrolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.39004	6.54135	3.11978	3.57418	2.73298	5.2576599999999996
GO:0016788	hydrolase activity, acting on ester bonds	molecular_function	Clostridium	Clostridium thermocellum	24.1927	112.856	133.745	239.459	240.616	272.626
GO:0016788	hydrolase activity, acting on ester bonds	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.6673	15.5307	13.405	14.5746	16.6134	19.4505
GO:0016788	hydrolase activity, acting on ester bonds	molecular_function	Escherichia	Escherichia coli	0.359263	0	0.0618859	0	0	0
GO:0016788	hydrolase activity, acting on ester bonds	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.11366	2.4331	3.92376	3.21026	0.962481	1.75975
GO:0016790	thiolester hydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	0.635138	3.35602	4.71429	6.21626	8.14849	13.8948
GO:0016790	thiolester hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.381719	0	0.335681	0	0	0
GO:0016791	phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	1.85348	10.1261	8.60101	22.7806	24.3596	18.8439
GO:0016791	phosphatase activity	molecular_function	Escherichia	Escherichia coli	1.12968	0	0.270367	0	0	0.0419435
GO:0016795	phosphoric triester hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0461291	0	0.0378893	0	0	0
GO:0016798	hydrolase activity, acting on glycosyl bonds	molecular_function	Clostridium	Clostridium thermocellum	13.361	27.8183	15.0313	55.0456	56.3294	81.1271
GO:0016798	hydrolase activity, acting on glycosyl bonds	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	99.2343	61.2982	62.9423	43.6585	69.2681	59.5412
GO:0016798	hydrolase activity, acting on glycosyl bonds	molecular_function	Escherichia	Escherichia coli	0.288076	0	0.435367	0	0	0.175277
GO:0016805	dipeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	0.309172	1.84039	0.688639	4.5854799999999996	4.02984	5.22299
GO:0016805	dipeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.9339	18.7187	13.0648	22.0688	19.0866	15.9968
GO:0016805	dipeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0461291	0	0.0378893	0	0	0
GO:0016807	cysteine-type carboxypeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0143151	0	0	0	0	0
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	Clostridium	Clostridium thermocellum	41.9027	75.2149	73.5632	156.028	132.134	159.755
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	258.911	224.072	204.845	214.696	259.126	236.585
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	Escherichia	Escherichia coli	0.283312	0	0.29274	0	0	0.101221
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.212393	0.593082	0.134733	0.774232	0.441719	0.465971
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	23.564	5.88078	5.84105	6.14106	7.45656	5.88991
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0872827
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.261074	0.588694	0.812726	0.357931	0.0390435	0.174792
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular_function	Escherichia	Escherichia coli	0.0786479	0	0	0	0	0
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	31.334	20.0835	26.696	23.9334	29.1499	17.6021
GO:0016817	hydrolase activity, acting on acid anhydrides	molecular_function	Escherichia	Escherichia coli	0.123538	0	0	0	0	0
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	molecular_function	Escherichia	Escherichia coli	0.127402	0	0	0	0	0.151831
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	Escherichia	Escherichia coli	0.0180336	0	0	0	0	0
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.498476	0.104082	0.292921	0.744661	0.0469868	0.557296
GO:0016829	lyase activity	molecular_function	Clostridium	Clostridium thermocellum	43.1951	251.02	228.725	643.928	620.508	599.84
GO:0016829	lyase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	170.495	91.7257	80.737	122.151	151.113	102.012
GO:0016829	lyase activity	molecular_function	Escherichia	Escherichia coli	0.208626	0	0.0458281	0	0	0
GO:0016829	lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.7801	5.12952	3.69335	3.16062	1.6869	2.46513
GO:0016831	carboxy-lyase activity	molecular_function	Escherichia	Escherichia coli	0.113014	0	0	0	0	0
GO:0016831	carboxy-lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.173288	0.290917	0.321247	0.177324	0.0580336	0.0576602
GO:0016832	aldehyde-lyase activity	molecular_function	Clostridium	Clostridium thermocellum	4.18625	33.5688	32.7505	51.4121	45.198	55.465
GO:0016832	aldehyde-lyase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.467166	0	0	0
GO:0016833	oxo-acid-lyase activity	molecular_function	Escherichia	Escherichia coli	0.0401017	0	0.148851	0	0	0
GO:0016833	oxo-acid-lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.121538	0.352236	0.19431	0.0565144	0.252599
GO:0016835	carbon-oxygen lyase activity	molecular_function	Escherichia	Escherichia coli	0.065062	0	0	0	0	0
GO:0016836	hydro-lyase activity	molecular_function	Clostridium	Clostridium thermocellum	10.7124	94.1762	47.619	230.162	116.762	364.765
GO:0016836	hydro-lyase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.5226	16.506	11.0525	16.5646	19.4523	14.2968
GO:0016836	hydro-lyase activity	molecular_function	Escherichia	Escherichia coli	0.14981	0	0	0	0	0
GO:0016836	hydro-lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.642478	2.32827	1.93741	1.91555	1.04089	1.80335
GO:0016837	carbon-oxygen lyase activity, acting on polysaccharides	molecular_function	Escherichia	Escherichia coli	0.55124	0	0	0	0	0.0656156
GO:0016840	carbon-nitrogen lyase activity	molecular_function	Clostridium	Clostridium thermocellum	2.86788	11.0986	10.9256	39.106	36.1662	33.0985
GO:0016840	carbon-nitrogen lyase activity	molecular_function	Escherichia	Escherichia coli	0.0464694	0	0	0	0	0.12389
GO:0016840	carbon-nitrogen lyase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.127159	0.487086	0.236087	0.994084	0.198647	0.549632
GO:0016851	magnesium chelatase activity	molecular_function	Clostridium	Clostridium thermocellum	2.23945	17.4025	12.2372	39.5776	34.6634	54.8841
GO:0016851	magnesium chelatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.989807	1.17071	0.813673	1.09185	0.833826	0.786255
GO:0016851	magnesium chelatase activity	molecular_function	Escherichia	Escherichia coli	0.585874	0	0.528331	0	0	0.0471824
GO:0016851	magnesium chelatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.87559	2.37592	2.75528	1.30118	0.85733	1.36729
GO:0016852	sirohydrochlorin cobaltochelatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.196916	0.379841	0.419758	0.457866	1.36338
GO:0016853	isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	13.9559	63.2049	53.7063	163.665	157.755	206.418
GO:0016853	isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	145.812	229.964	301.385	169.261	201.171	138.079
GO:0016853	isomerase activity	molecular_function	Escherichia	Escherichia coli	0.324411	0	0.119802	0	0	0
GO:0016853	isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.41757	3.25226	2.36899	4.12133	1.97479	3.57688
GO:0016855	racemase and epimerase activity, acting on amino acids and derivatives	molecular_function	Escherichia	Escherichia coli	0.0595692	0	0	0	0	0
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	molecular_function	Clostridium	Clostridium thermocellum	5.98225	36.2569	27.1105	100.723	88.9785	89.6585
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	molecular_function	Escherichia	Escherichia coli	0.071381	0	0.0471361	0	0	0.0951734
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0682701	0.087373	0.168878	0.0465817	0	0.121109
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.6022	8.82271	4.81488	8.87252	10.4749	8.15105
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	molecular_function	Escherichia	Escherichia coli	0.336174	0	0	0	0	0
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	molecular_function	Clostridium	Clostridium thermocellum	3.3367	20.9109	5.65737	28.5364	43.3716	65.2845
GO:0016868	intramolecular transferase activity, phosphotransferases	molecular_function	Clostridium	Clostridium thermocellum	0.0630447	0.363214	0.234012	1.16099	0.787924	1.00658
GO:0016868	intramolecular transferase activity, phosphotransferases	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	23.5838	15.8669	9.26421	28.7642	30.7572	21.7891
GO:0016868	intramolecular transferase activity, phosphotransferases	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.228968	0.281535	0.153813	0	0.0373941	0
GO:0016869	intramolecular transferase activity, transferring amino groups	molecular_function	Escherichia	Escherichia coli	0.027658	0	0	0	0	0
GO:0016872	intramolecular lyase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.691985	1.13095	2.00534	0.404388	0.791896	0.524763
GO:0016872	intramolecular lyase activity	molecular_function	Escherichia	Escherichia coli	0.0900222	0	0	0	0	0
GO:0016874	ligase activity	molecular_function	Clostridium	Clostridium thermocellum	12.658	55.6299	42.6905	168.182	143.736	102.032
GO:0016874	ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	179.082	140.979	174.861	112.425	124.84	93.3947
GO:0016874	ligase activity	molecular_function	Escherichia	Escherichia coli	0.549077	0	0.627565	0	0	0.119363
GO:0016874	ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.678156	0.936366	1.15405	0.786344	0.654886	0.852453
GO:0016878	acid-thiol ligase activity	molecular_function	Escherichia	Escherichia coli	0.069704	0	0.0642766	0	0	0
GO:0016879	ligase activity, forming carbon-nitrogen bonds	molecular_function	Clostridium	Clostridium thermocellum	3.23407	21.9685	15.6691	74.2925	67.1286	68.034
GO:0016879	ligase activity, forming carbon-nitrogen bonds	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.9417	9.21365	4.19593	3.90655	4.23014	3.57849
GO:0016879	ligase activity, forming carbon-nitrogen bonds	molecular_function	Escherichia	Escherichia coli	0.178051	0	0.0787106	0	0	0
GO:0016879	ligase activity, forming carbon-nitrogen bonds	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.20631	1.89798	2.29411	0.996993	0.777333	2.23452
GO:0016881	acid-amino acid ligase activity	molecular_function	Clostridium	Clostridium thermocellum	1.57886	8.27644	7.72167	23.5333	21.6319	23.9263
GO:0016881	acid-amino acid ligase activity	molecular_function	Escherichia	Escherichia coli	0.0397128	0	0.0737038	0	0	0
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	Clostridium	Clostridium thermocellum	69.1656	494.745	265.457	1228.89	1051.44	1149.61
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	12.7622	20.7861	18.2133	17.6636	24.1738	13.057
GO:0016887	ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	120.268	683.451	505.781	1920.06	1561.26	1613.93
GO:0016887	ATPase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1114.05	637.734	789.1	515.807	630.094	456.637
GO:0016887	ATPase activity	molecular_function	Escherichia	Escherichia coli	1.60183	0	0.975019	0	0	0.786352
GO:0016887	ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.15995	6.1794	5.13297	4.15229	2.49748	4.77539
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	Clostridium	Clostridium thermocellum	1.72782	10.1905	6.13095	35.7433	29.6849	20.023
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	23.7802	10.2669	11.4827	9.10722	10.74	9.14537
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	Escherichia	Escherichia coli	0.0768008	0	0.142536	0	0	0
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.827796	0.530586	0.72531	1.20108	0.612565	0.522758
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	molecular_function	Escherichia	Escherichia coli	0.0155303	0	0	0	0	0
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	molecular_function	Clostridium	Clostridium thermocellum	12.8185	56.9574	36.3573	162.379	129.516	111.612
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.4209	4.47964	7.20398	4.03809	4.54913	2.72074
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	molecular_function	Escherichia	Escherichia coli	0.0258109	0	0	0	0	0.0119007
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.288392	0.486852	0.199596	0.0387477	0.0336829	0
GO:0016920	pyroglutamyl-peptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	40.8456	71.071	59.7194	78.6609	88.171	67.0996
GO:0016966	nitric oxide reductase activity	molecular_function	Escherichia	Escherichia coli	0.0447681	0	0.124584	0	0	0
GO:0016985	mannan endo-1,4-beta-mannosidase activity	molecular_function	Clostridium	Clostridium thermocellum	41.2293	46.4253	52.9957	128.966	117.098	135.834
GO:0016987	sigma factor activity	molecular_function	Clostridium	Clostridium thermocellum	64.1625	339.573	262.041	939.367	878.372	972.412
GO:0016987	sigma factor activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	170.255	122.214	124.81	81.1139	113.434	92.5824
GO:0016987	sigma factor activity	molecular_function	Escherichia	Escherichia coli	0.536974	0	0.215338	0	0	0.0917454
GO:0016987	sigma factor activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.342298	0.657351	1.91549	1.08847	0	0.231191
GO:0016989	sigma factor antagonist activity	molecular_function	Clostridium	Clostridium thermocellum	0	1.24413	1.65441	4.88044	4.12021	4.4064
GO:0016989	sigma factor antagonist activity	molecular_function	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0016992	lipoate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	33.0985	42.7352	36.02	30.6123	37.2339	39.0065
GO:0016992	lipoate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0893174	0	0	0	0	0
GO:0016993	precorrin-8X methylmutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.206512	0	0.0957608	0.158398	0.276473	0.0686555
GO:0016994	precorrin-6A reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.35634	0.393172	0.171605	0.340787
GO:0016998	cell wall macromolecule catabolic process	biological_process	Escherichia	Escherichia coli	0.439126	0	0	0	0	0.0966933
GO:0017001	antibiotic catabolic process	biological_process	Escherichia	Escherichia coli	0.073617	0	0	0	0	0
GO:0017004	cytochrome complex assembly	biological_process	Clostridium	Clostridium thermocellum	7.81876	83.5873	67.8413	138.875	101.384	229.216
GO:0017004	cytochrome complex assembly	biological_process	Escherichia	Escherichia coli	0.381671	0	0.192785	0	0	0
GO:0017004	cytochrome complex assembly	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0	0.147645	0
GO:0017013	protein flavinylation	biological_process	Clostridium	Clostridium thermocellum	0.670865	14.7097	11.1055	32.1483	25.356	47.2252
GO:0017038	protein import	biological_process	Clostridium	Clostridium thermocellum	1.53359	8.4545	6.70407	23.1515	21.6566	17.3492
GO:0017038	protein import	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.2381	15.0365	29.4212	14.101	18.5976	11.9837
GO:0017038	protein import	biological_process	Escherichia	Escherichia coli	0.0846267	0	0.118404	0	0	0
GO:0017057	6-phosphogluconolactonase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0532706	0	0	0
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	molecular_function	Clostridium	Clostridium thermocellum	3.18101	9.1625	8.16429	42.2096	39.3841	31.042
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	53.6806	43.6106	43.2065	48.0188	47.6454	48.9161
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.259407	0.14355	0.062461	0.09333
GO:0017103	UTP:galactose-1-phosphate uridylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.59595	13.7924	5.45755	15.3531	18.278	12.0259
GO:0017108	5'-flap endonuclease activity	molecular_function	Escherichia	Escherichia coli	0.103438	0	0	0	0	0
GO:0017108	5'-flap endonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.232128	0	0.32251	0.475343	0.103718	0.0772576
GO:0017111	nucleoside-triphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	4.42378	27.4467	20.7349	59.5457	61.5965	71.5612
GO:0017111	nucleoside-triphosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.9694	79.6803	76.3232	58.9659	71.4159	58.7156
GO:0017111	nucleoside-triphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0136346	0	0	0	0	0
GO:0017111	nucleoside-triphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.556563	0.768948	1.08797	1.61763	0.995513	2.01636
GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.110802	0	0	0	0	0.0384186
GO:0017148	negative regulation of translation	biological_process	Clostridium	Clostridium thermocellum	1.39243	22.0746	15.9619	51.3402	47.5091	73.1241
GO:0017148	negative regulation of translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.65391	2.99453	3.27865	1.59564	2.6893	3.31622
GO:0017148	negative regulation of translation	biological_process	Escherichia	Escherichia coli	0.964482	0	0	0	0	0
GO:0017150	tRNA dihydrouridine synthase activity	molecular_function	Clostridium	Clostridium thermocellum	9.76146	48.7718	59.4041	84.9538	94.6885	113.978
GO:0017150	tRNA dihydrouridine synthase activity	molecular_function	Escherichia	Escherichia coli	0.137853	0	0.42418	0	0	0.0364136
GO:0017150	tRNA dihydrouridine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.126211	0.161211	1.24633	0.128852	0.149924	0.167548
GO:0017153	sodium:dicarboxylate symporter activity	molecular_function	Escherichia	Escherichia coli	0.170153	0	0.0387464	0	0	0
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.139875	0	0	0.200404
GO:0018106	peptidyl-histidine phosphorylation	biological_process	Escherichia	Escherichia coli	0.417033	0	0.500184	0	0	0.103032
GO:0018160	peptidyl-pyrromethane cofactor linkage	biological_process	Clostridium	Clostridium thermocellum	0.233319	3.13586	4.32944	6.23263	4.85062	5.67706
GO:0018160	peptidyl-pyrromethane cofactor linkage	biological_process	Escherichia	Escherichia coli	0.0613677	0	0.0569693	0	0	0
GO:0018160	peptidyl-pyrromethane cofactor linkage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.129659	0	0.241738	0.241185	0.26948
GO:0018298	protein-chromophore linkage	biological_process	Escherichia	Escherichia coli	0.0457645	0	0	0	0	0.0304632
GO:0018298	protein-chromophore linkage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265935	0.196403	0.151828	0	0.0730737	0
GO:0018307	enzyme active site formation	biological_process	Clostridium	Clostridium thermocellum	0.0764362	0.299178	0.290079	0.637695	0.418042	0.414617
GO:0018339	peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid	biological_process	Clostridium	Clostridium thermocellum	1.48308	13.9746	12.425	28.6716	24.4524	24.9415
GO:0018339	peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid	biological_process	Escherichia	Escherichia coli	0.0978481	0	0	0	0	0
GO:0018364	peptidyl-glutamine methylation	biological_process	Clostridium	Clostridium thermocellum	1.69703	8.97286	6.41728	11.9222	13.9485	13.8792
GO:0018364	peptidyl-glutamine methylation	biological_process	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0018378	cytochrome c-heme linkage via heme-L-cysteine	biological_process	Escherichia	Escherichia coli	0.0655237	0	0.100903	0	0	0
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	molecular_function	Escherichia	Escherichia coli	0.0479276	0	0	0	0	0
GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	Clostridium	Clostridium thermocellum	0.130416	31.3103	29.1451	43.3765	37.6878	33.5279
GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0834844	0	0	0.294885	0.159451	0.11144
GO:0018493	formylmethanofuran dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.53774	3.50888	3.31902	2.70077	1.62173	2.40061
GO:0018537	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	7.03269	3.21927	8.41721	8.43702	7.34774	17.9235
GO:0018580	nitronate monooxygenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	90.8081	8.77324	9.87973	39.3985	47.2665	24.2261
GO:0018697	carbonyl sulfide nitrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.545869	1.22402	0.7655	2.14768	0.836213	1.36341
GO:0018738	S-formylglutathione hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0710651	0	0	0	0	0
GO:0018741	alkyl sulfatase activity	molecular_function	Escherichia	Escherichia coli	0.0264671	0	0	0	0	0
GO:0018759	methenyltetrahydromethanopterin cyclohydrolase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.209234	0.459268	0.166442	0.428189	0.160406	0.874961
GO:0018801	glutaconyl-CoA decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.7383	13.8552	10.5367	15.8808	17.9128	16.441
GO:0018937	nitroglycerin metabolic process	biological_process	Escherichia	Escherichia coli	0.165389	0	0	0	0	0
GO:0019003	GDP binding	molecular_function	Escherichia	Escherichia coli	0.0286545	0	0	0	0	0
GO:0019073	viral DNA genome packaging	biological_process	Escherichia	Escherichia coli	20.3105	0	23.4071	0	0	18.4157
GO:0019076	viral release from host cell	biological_process	Escherichia	Escherichia coli	0.209817	0	0.588457	0	0	0.0758994
GO:0019104	DNA N-glycosylase activity	molecular_function	Clostridium	Clostridium thermocellum	8.44359	38.6602	41.3978	94.1453	87.3801	154.826
GO:0019104	DNA N-glycosylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.8755	10.1067	11.4614	13.4119	20.5167	15.9538
GO:0019104	DNA N-glycosylase activity	molecular_function	Escherichia	Escherichia coli	0.100011	0	0	0	0	0
GO:0019104	DNA N-glycosylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.164322	0.045388	0.235607	0.293152
GO:0019107	myristoyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.029578	0	0	0	0	0
GO:0019134	glucosamine-1-phosphate N-acetyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	6.26833	35.7007	27.2547	96.8199	94.1636	84.6506
GO:0019134	glucosamine-1-phosphate N-acetyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.0894	14.1176	12.1005	34.4997	35.4584	19.8786
GO:0019134	glucosamine-1-phosphate N-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.019905	0	0.0738842	0	0	0
GO:0019134	glucosamine-1-phosphate N-acetyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.151609	0.166391	0.200994	0.15514	0.116067	0.172948
GO:0019143	3-deoxy-manno-octulosonate-8-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.21633	0	0	0
GO:0019144	ADP-sugar diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.118264	0	0	0	0	0
GO:0019146	arabinose-5-phosphate isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.107759	0	0	0.0772576
GO:0019148	D-cysteine desulfhydrase activity	molecular_function	Escherichia	Escherichia coli	0.0580624	0	0.107759	0	0	0
GO:0019159	nicotinamide-nucleotide amidase activity	molecular_function	Escherichia	Escherichia coli	0.0696311	0	0	0	0	0
GO:0019164	pyruvate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	37.7541	467.125	390.5	1143.26	1120.48	917.719
GO:0019164	pyruvate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.102	15.7809	22.2174	16.6257	21.7097	12.2023
GO:0019164	pyruvate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.082415	0	0.283448	0.430328	0.559241	0.166028
GO:0019172	glyoxalase III activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.175277
GO:0019180	dTDP-4-amino-4,6-dideoxygalactose transaminase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0459634	0	0	0
GO:0019239	deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	0	53.2952	41.7632	133.282	125.444	119.676
GO:0019242	methylglyoxal biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	8.8476	8.17008	7.28098	5.97475	7.36417	4.43159
GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	biological_process	Escherichia	Escherichia coli	0.226611	0	0.148851	0	0	0.175277
GO:0019249	lactate biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.175277
GO:0019251	anaerobic cobalamin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.196916	0.379841	0.419758	0.457866	1.36338
GO:0019253	reductive pentose-phosphate cycle	biological_process	Escherichia	Escherichia coli	0.11593	0	0	0	0	0.1225
GO:0019262	N-acetylneuraminate catabolic process	biological_process	Escherichia	Escherichia coli	0.205345	0	0	0	0	0.0434635
GO:0019264	glycine biosynthetic process from serine	biological_process	Clostridium	Clostridium thermocellum	2.54412	52.7806	35.9423	179.599	189.141	149.235
GO:0019264	glycine biosynthetic process from serine	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.6804	11.9841	12.0337	8.85192	9.73997	6.94814
GO:0019264	glycine biosynthetic process from serine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.106889	0.164198	0.236042	0.436595	0.0381754	0.0853423
GO:0019272	L-alanine biosynthetic process from pyruvate	biological_process	Escherichia	Escherichia coli	0.0446465	0	0	0	0	0
GO:0019277	UDP-N-acetylgalactosamine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	15.7121	94.3411	68.7886	205.784	178.629	204.708
GO:0019277	UDP-N-acetylgalactosamine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.7477	23.8692	17.1089	21.6449	23.5611	21.4403
GO:0019277	UDP-N-acetylgalactosamine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0600067	0	0.0812816	0	0	0
GO:0019281	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine	biological_process	Clostridium	Clostridium thermocellum	1.80171	18.6499	14.2566	39.4573	34.2343	40.4424
GO:0019281	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine	biological_process	Escherichia	Escherichia coli	0.155789	0	0.346913	0	0	0
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine	biological_process	Clostridium	Clostridium thermocellum	1.90797	8.33124	5.07952	33.3417	25.5352	24.3338
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.4369	12.727	27.7473	8.96712	12.2831	20.0084
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.525672	1.42523	1.09036	0.253054	0.414178	0.369989
GO:0019285	glycine betaine biosynthetic process from choline	biological_process	Escherichia	Escherichia coli	0.086328	0	0.162338	0	0	0.0355404
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0638711	0	0	0.0326296	0.0569702	0
GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	biological_process	Clostridium	Clostridium thermocellum	17.5654	96.757	66.0977	306.882	268.141	243.195
GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	42.2315	46.6955	32.9517	47.2494	54.0949	40.364
GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	biological_process	Escherichia	Escherichia coli	0.219709	0	0	0	0	0
GO:0019290	siderophore biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0814186	0	0	0	0	0
GO:0019294	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.0639608	0	0	0
GO:0019295	coenzyme M biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.912739	1.67978	1.961	2.31954	1.29925	1.0969
GO:0019298	coenzyme B biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.18198	0.0879123	0.242384	0.0846197	0
GO:0019299	rhamnose metabolic process	biological_process	Clostridium	Clostridium thermocellum	5.56439	29.6624	24.26	87.8646	80.5556	79.0305
GO:0019299	rhamnose metabolic process	biological_process	Escherichia	Escherichia coli	0.17375	0	0	0	0	0.232064
GO:0019301	rhamnose catabolic process	biological_process	Escherichia	Escherichia coli	0.13795	0	0	0	0	0
GO:0019303	D-ribose catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.691985	1.13095	2.00534	0.404388	0.791896	0.524763
GO:0019303	D-ribose catabolic process	biological_process	Escherichia	Escherichia coli	0.148935	0	0	0	0	0.0783571
GO:0019305	dTDP-rhamnose biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.26015	1.99964	4.92832	0.722029	1.58891	1.92271
GO:0019305	dTDP-rhamnose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.430036	0	0.12314	0	0	0
GO:0019305	dTDP-rhamnose biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.210813	0.0640362	0.72522	0.15989	0.20162	0.387873
GO:0019316	D-allose catabolic process	biological_process	Escherichia	Escherichia coli	0.0890257	0	0.704922	0	0	0
GO:0019323	pentose catabolic process	biological_process	Escherichia	Escherichia coli	0.0890257	0	0.0933701	0	0	0
GO:0019324	L-lyxose metabolic process	biological_process	Escherichia	Escherichia coli	0.0359457	0	0.267842	0	0	0
GO:0019344	cysteine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.170566	28.8948	17.7178	62.1958	54.7957	58.7528
GO:0019344	cysteine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.119503	0	0	0	0	0
GO:0019354	siroheme biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.0182523	12.9279	7.92212	23.4066	22.693	32.3801
GO:0019354	siroheme biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.08384	1.48067	1.34034	1.00281	0.829117	0.892133
GO:0019357	nicotinate nucleotide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0461534	0	0	0	0	0.0614116
GO:0019358	nicotinate nucleotide salvage	biological_process	Clostridium	Clostridium thermocellum	1.5758	3.20363	4.54108	9.51954	9.20165	8.45937
GO:0019363	pyridine nucleotide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0696311	0	0	0	0	0
GO:0019379	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)	biological_process	Clostridium	Clostridium thermocellum	0.170566	28.8948	17.7178	62.1958	54.7957	58.7528
GO:0019380	3-phenylpropionate catabolic process	biological_process	Escherichia	Escherichia coli	0.172632	0	0.281554	0	0	0
GO:0019386	methanogenesis, from carbon dioxide	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	35.4646	20.0618	50.7883	37.8944	33.1387	60.675
GO:0019402	galactitol metabolic process	biological_process	Escherichia	Escherichia coli	0.124996	0	0	0	0	0.07577
GO:0019404	galactitol catabolic process	biological_process	Escherichia	Escherichia coli	0.0436744	0	0.0810561	0	0	0
GO:0019419	sulfate reduction	biological_process	Escherichia	Escherichia coli	0.0639926	0	0	0	0	0
GO:0019427	acetyl-CoA biosynthetic process from acetate	biological_process	Escherichia	Escherichia coli	0.0624857	0	0	0	0	0
GO:0019427	acetyl-CoA biosynthetic process from acetate	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.321105	0.603863	0.128914	0.461639	0	0.431271
GO:0019430	removal of superoxide radicals	biological_process	Clostridium	Clostridium thermocellum	3.34271	26.5836	22.3044	73.621	51.4425	40.9378
GO:0019430	removal of superoxide radicals	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	60.5844	45.6812	40.6282	27.2136	35.3746	29.7026
GO:0019430	removal of superoxide radicals	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.560136	3.79685	1.7356	1.12194	1.27526	1.14176
GO:0019439	aromatic compound catabolic process	biological_process	Escherichia	Escherichia coli	0.244353	0	0.205008	0	0	0
GO:0019441	tryptophan catabolic process to kynurenine	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.5656	12.5449	8.71175	11.5431	10.73	8.61288
GO:0019441	tryptophan catabolic process to kynurenine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.320352	0.531379	0.222735	0.184064	0.107169	0.319411
GO:0019464	glycine decarboxylation via glycine cleavage system	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	706.074	325.416	401.597	307.487	371.456	244.037
GO:0019478	D-amino acid catabolic process	biological_process	Clostridium	Clostridium thermocellum	3.31886	15.3888	14.6693	64.3926	55.4333	51.6832
GO:0019478	D-amino acid catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	17.6673	15.5307	13.405	14.5746	16.6134	19.4505
GO:0019491	ectoine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.395184	0.94332	0	0	0	0.131458
GO:0019509	L-methionine biosynthetic process from methylthioadenosine	biological_process	Clostridium	Clostridium thermocellum	1.90797	8.33124	5.07952	33.3417	25.5352	24.3338
GO:0019509	L-methionine biosynthetic process from methylthioadenosine	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.4369	12.727	27.7473	8.96712	12.2831	20.0084
GO:0019516	lactate oxidation	biological_process	Escherichia	Escherichia coli	0.176836	0	0.0692383	0	0	0.0506104
GO:0019516	lactate oxidation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	6.10015	1.48707	6.2415	6.12275	5.15822	12.196
GO:0019518	L-threonine catabolic process to glycine	biological_process	Escherichia	Escherichia coli	0.374696	0	0	0	0	0
GO:0019521	D-gluconate metabolic process	biological_process	Escherichia	Escherichia coli	0.431421	0	0.288636	0	0	0.128612
GO:0019538	protein metabolic process	biological_process	Clostridium	Clostridium thermocellum	21.8133	263.562	347.214	110.844	101.05	103.011
GO:0019538	protein metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	525.539	231.02	388.516	41.1582	53.0827	48.5591
GO:0019544	arginine catabolic process to glutamate	biological_process	Escherichia	Escherichia coli	0.241704	0	0	0	0	0
GO:0019545	arginine catabolic process to succinate	biological_process	Escherichia	Escherichia coli	0.241704	0	0	0	0	0
GO:0019546	arginine deiminase pathway	biological_process	Clostridium	Clostridium thermocellum	1.50707	2.58642	1.39825	7.4204	5.77356	4.76255
GO:0019546	arginine deiminase pathway	biological_process	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0019547	arginine catabolic process to ornithine	biological_process	Clostridium	Clostridium thermocellum	1.50707	2.58642	1.39825	7.4204	5.77356	4.76255
GO:0019552	glutamate catabolic process via 2-hydroxyglutarate	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	21.7383	13.8552	10.5367	15.8808	17.9128	16.441
GO:0019556	histidine catabolic process to glutamate and formamide	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.0551	11.8131	40.4703	1.99762	3.44961	5.27732
GO:0019557	histidine catabolic process to glutamate and formate	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	22.0551	11.8131	40.4703	1.99762	3.44961	5.27732
GO:0019563	glycerol catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0019563	glycerol catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0350877
GO:0019588	anaerobic glycerol catabolic process	biological_process	Escherichia	Escherichia coli	0.0508684	0	0	0	0	0
GO:0019594	mannitol metabolic process	biological_process	Escherichia	Escherichia coli	0.0797659	0	0.225757	0	0	0
GO:0019605	butyrate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	81.3009	96.7253	101.091	83.5603	101.809	119.134
GO:0019627	urea metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.0764362	0.299178	0.290079	0.637695	0.418042	0.414617
GO:0019630	quinate metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.38574	7.35655	3.7173	17.0606	15.9985	19.0732
GO:0019632	shikimate metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.36543	6.36931	4.52466	37.8689	40.8847	40.2398
GO:0019632	shikimate metabolic process	biological_process	Escherichia	Escherichia coli	0.181527	0	0	0	0	0
GO:0019632	shikimate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.307155	1.98349	0.569964	0.0392948	0.171431	0.306379
GO:0019645	anaerobic electron transport chain	biological_process	Escherichia	Escherichia coli	0.0810054	0	0.252686	0	0	0
GO:0019646	aerobic electron transport chain	biological_process	Escherichia	Escherichia coli	0.146432	0	0.0646374	0	0	0.023187
GO:0019674	NAD metabolic process	biological_process	Clostridium	Clostridium thermocellum	3.27337	43.3958	38.1945	99.6322	94.2849	136.194
GO:0019674	NAD metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	26.7214	39.4559	31.2051	22.3689	30.5419	23.339
GO:0019674	NAD metabolic process	biological_process	Escherichia	Escherichia coli	0.233368	0	0	0	0	0
GO:0019674	NAD metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.207727	0.398826	0.192649	0.070855	0.15459	0
GO:0019693	ribose phosphate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.222333	0.573012	0.41146	0.532295	0.266599	0.446632
GO:0019698	D-galacturonate catabolic process	biological_process	Escherichia	Escherichia coli	1.43953	0	0	0	0	0
GO:0019700	organic phosphonate catabolic process	biological_process	Escherichia	Escherichia coli	0.0798145	0	0	0	0	0
GO:0019740	nitrogen utilization	biological_process	Escherichia	Escherichia coli	0.0551702	0	0	0	0	0
GO:0019752	carboxylic acid metabolic process	biological_process	Escherichia	Escherichia coli	0.298235	0	0	0	0	0
GO:0019808	polyamine binding	molecular_function	Clostridium	Clostridium thermocellum	2.86812	14.2759	7.34115	83.8084	72.8267	32.8495
GO:0019808	polyamine binding	molecular_function	Escherichia	Escherichia coli	0	0	0.181102	0	0	0
GO:0019825	oxygen binding	molecular_function	Escherichia	Escherichia coli	0.0466881	0	0	0	0	0
GO:0019829	cation-transporting ATPase activity	molecular_function	Clostridium	Clostridium thermocellum	5.28287	21.5243	18.7184	79.1633	55.1678	45.7095
GO:0019829	cation-transporting ATPase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.390031	0.365314	0.395041	0.191326	0.0816681	0.210461
GO:0019835	cytolysis	biological_process	Escherichia	Escherichia coli	0.154063	0	0.176907	0	0	0
GO:0019843	rRNA binding	molecular_function	Clostridium	Clostridium thermocellum	332.151	1592.04	935.931	6762.96	5484.78	5699.01
GO:0019843	rRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1995.01	1799.96	1399.49	1858.17	2246	1681.5
GO:0019843	rRNA binding	molecular_function	Escherichia	Escherichia coli	0.855989	0	2.05938	0	0	0.40443
GO:0019843	rRNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	7.89043	20.042	37.5021	51.1639	18.2033	27.5042
GO:0019853	L-ascorbic acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0540036	0	0	0	0	0
GO:0019854	L-ascorbic acid catabolic process	biological_process	Escherichia	Escherichia coli	0.0683187	0	0	0	0	0
GO:0019856	pyrimidine nucleobase biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.1579	4.68626	2.36768	1.02219	2.77335	2.067
GO:0019856	pyrimidine nucleobase biosynthetic process	biological_process	Escherichia	Escherichia coli	0.054198	0	0	0	0	0
GO:0019877	diaminopimelate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	10.3515	38.2045	33.9355	110.667	117.318	123.081
GO:0019877	diaminopimelate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.121933	0	0	0	0	0
GO:0019877	diaminopimelate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.952354	1.1316	2.39713	2.38761	0.732126	1.87084
GO:0019932	second-messenger-mediated signaling	biological_process	Clostridium	Clostridium thermocellum	4.19311	21.5017	17.5922	87.8474	83.4249	100.137
GO:0020037	heme binding	molecular_function	Clostridium	Clostridium thermocellum	0.268876	23.4922	17.0868	64.5776	54.314	45.8254
GO:0020037	heme binding	molecular_function	Escherichia	Escherichia coli	1.36037	0	0.422737	0	0	0.0680087
GO:0020037	heme binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.126576	0.486199	0.258414	0.155438	0.0676914	0.0673619
GO:0022611	dormancy process	biological_process	Escherichia	Escherichia coli	0.0428724	0	0	0	0	0
GO:0022820	potassium ion symporter activity	molecular_function	Clostridium	Clostridium thermocellum	1.88529	7.99094	4.77929	25.7575	26.9227	25.4754
GO:0022820	potassium ion symporter activity	molecular_function	Escherichia	Escherichia coli	0.0557049	0	0	0	0	0
GO:0022857	transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.641821	0	0.523008	0	0	0.102935
GO:0022872	protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.201845	0	0.29901	0	0	0.0426873
GO:0022877	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	92.4241	20.5231	28.3484	18.3597	14.3406	8.53233
GO:0022877	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity	molecular_function	Escherichia	Escherichia coli	0.0550244	0	0.469873	0	0	0.0209879
GO:0022885	bacteriocin transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	7.07246	25.0548	21.4841	39.2775	35.7906	61.1063
GO:0022889	serine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0443792	0	0	0	0	0
GO:0022891	substrate-specific transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.698766	0	0.306904	0	0	0.0769342
GO:0022900	electron transport chain	biological_process	Clostridium	Clostridium thermocellum	27.3023	113.233	112.84	293.625	296.322	288.779
GO:0022900	electron transport chain	biological_process	Escherichia	Escherichia coli	0.0534689	0	0.297747	0	0	0
GO:0022904	respiratory electron transport chain	biological_process	Escherichia	Escherichia coli	0.395208	0	0.108165	0	0	0.0508367
GO:0023014	signal transduction by protein phosphorylation	biological_process	Escherichia	Escherichia coli	0.571121	0	0.500184	0	0	0.103032
GO:0030001	metal ion transport	biological_process	Clostridium	Clostridium thermocellum	24.9573	165.741	102.104	716.088	559.563	560.753
GO:0030001	metal ion transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.7306	9.79903	8.87016	6.29811	7.3781	6.73538
GO:0030001	metal ion transport	biological_process	Escherichia	Escherichia coli	0.14072	0	0	0	0	0
GO:0030001	metal ion transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.296339	0.31612	0	0.269493	0.176445	0.131458
GO:0030060	L-malate dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.440074	0.281489	0.162202	0.240295	0.104847	0
GO:0030091	protein repair	biological_process	Clostridium	Clostridium thermocellum	0.217497	2.60971	0.706365	3.28263	1.65025	7.94968
GO:0030091	protein repair	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.85163	2.10927	1.80651	1.83144	1.68072	1.29517
GO:0030091	protein repair	biological_process	Escherichia	Escherichia coli	0.61742	0	0.170863	0	0	0
GO:0030091	protein repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.610761	0.259319	0.964644	0.359672	0.0430586	0.106039
GO:0030145	manganese ion binding	molecular_function	Clostridium	Clostridium thermocellum	21.8883	203.144	212.555	520.555	460.296	438.792
GO:0030145	manganese ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	30.5053	18.0302	14.1882	22.8974	23.4574	20.9737
GO:0030145	manganese ion binding	molecular_function	Escherichia	Escherichia coli	1.623	0	1.43235	0	0	0.34221
GO:0030145	manganese ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.1594	2.28439	3.22316	2.43329	1.48253	3.45237
GO:0030151	molybdenum ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	13.8821	19.0385	12.9373	17.7183	19.5629	16.2159
GO:0030151	molybdenum ion binding	molecular_function	Escherichia	Escherichia coli	0.758043	0	0	0	0	0.0514188
GO:0030151	molybdenum ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.100011	1.60431	0.342583	0.798878	0.150792	1.45312
GO:0030153	bacteriocin immunity	biological_process	Escherichia	Escherichia coli	0.424738	0	0.188139	0	0	0
GO:0030163	protein catabolic process	biological_process	Clostridium	Clostridium thermocellum	5.84393	40.4205	28.0088	109.896	98.4439	102.769
GO:0030163	protein catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.5312	28.6788	32.6612	16.4149	18.2525	20.9937
GO:0030163	protein catabolic process	biological_process	Escherichia	Escherichia coli	0.412172	0	0.100722	0	0	0.0362196
GO:0030163	protein catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.613459	1.5799	1.39239	0.716359	0.489531	1.12297
GO:0030170	pyridoxal phosphate binding	molecular_function	Clostridium	Clostridium thermocellum	61.3959	1793.24	1516.57	1656.84	1637.87	1670.83
GO:0030170	pyridoxal phosphate binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	538.617	260.019	385.875	230.782	249.884	168.924
GO:0030170	pyridoxal phosphate binding	molecular_function	Escherichia	Escherichia coli	1.77874	0	0.977725	0	0	0.136567
GO:0030170	pyridoxal phosphate binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.12535	3.27695	2.84959	4.34625	2.66794	4.28542
GO:0030234	enzyme regulator activity	molecular_function	Clostridium	Clostridium thermocellum	29.5502	131.469	92.9205	281.49	268.928	416.262
GO:0030234	enzyme regulator activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0514188
GO:0030234	enzyme regulator activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.642259	1.17865	0.205956	0.531599	0.464442	1.83536
GO:0030244	cellulose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0566041	0	0.280742	0	0	0.0229283
GO:0030245	cellulose catabolic process	biological_process	Clostridium	Clostridium thermocellum	360.113	492.19	489.415	1494.12	1317.1	1291.15
GO:0030245	cellulose catabolic process	biological_process	Escherichia	Escherichia coli	0.0761932	0	0	0	0	0
GO:0030246	carbohydrate binding	molecular_function	Clostridium	Clostridium thermocellum	236.158	332.987	319.585	866.912	764.217	811.045
GO:0030246	carbohydrate binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	246.44	87.6649	114.489	82.2803	91.0537	71.6753
GO:0030246	carbohydrate binding	molecular_function	Escherichia	Escherichia coli	4.46643	0	3.38907	0	0	1.25439
GO:0030246	carbohydrate binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.47961	2.4815	1.77877	2.41031	1.75273	3.16953
GO:0030248	cellulose binding	molecular_function	Clostridium	Clostridium thermocellum	96.9815	115.552	93.088	368.944	317.694	349.076
GO:0030254	protein secretion by the type III secretion system	biological_process	Clostridium	Clostridium thermocellum	1.77383	6.01273	5.19088	50.7058	47.3394	37.1062
GO:0030259	lipid glycosylation	biological_process	Clostridium	Clostridium thermocellum	1.58956	8.72969	6.41773	32.6025	24.0076	23.7881
GO:0030259	lipid glycosylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	23.0057	10.0247	7.60845	14.6403	15.6966	16.805
GO:0030259	lipid glycosylation	biological_process	Escherichia	Escherichia coli	0.0536877	0	0	0	0	0
GO:0030259	lipid glycosylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0861093	0	0	0	0	0
GO:0030261	chromosome condensation	biological_process	Clostridium	Clostridium thermocellum	35.245	378.631	231.085	1476.91	1305.28	1935.4
GO:0030261	chromosome condensation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	907.442	2125.74	1515.98	841.108	1142.16	1196.14
GO:0030261	chromosome condensation	biological_process	Escherichia	Escherichia coli	0.109368	0	0	0	0	0
GO:0030266	quinate 3-dehydrogenase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.0327619	0	0	0	0	0
GO:0030268	methylenetetrahydromethanopterin dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	6.52795	5.96223	21.7131	10.4726	10.4144	28.2812
GO:0030269	tetrahydromethanopterin S-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	26.7966	9.15881	23.6886	22.4062	18.9856	22.9934
GO:0030270	formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.615063	0.430891	1.07935	0.989756	0.893184	2.66469
GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	molecular_function	Clostridium	Clostridium thermocellum	4.04441	28.8063	16.8272	112.805	85.4843	97.7769
GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.199145	0	0	0.21418
GO:0030337	DNA polymerase processivity factor activity	molecular_function	Escherichia	Escherichia coli	0.0136346	0	0	0	0	0
GO:0030337	DNA polymerase processivity factor activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.166118	0.159437	0.0770868	0.595043	0.519394	1.1055
GO:0030388	fructose 1,6-bisphosphate metabolic process	biological_process	Clostridium	Clostridium thermocellum	9.251	187.596	131.683	467.604	448.693	467.214
GO:0030388	fructose 1,6-bisphosphate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	61.2687	66.3204	53.7575	64.3077	73.8739	48.3358
GO:0030393	fructoselysine metabolic process	biological_process	Escherichia	Escherichia coli	0.040928	0	0.0374834	0	0	0
GO:0030409	glutamate formimidoyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	38.7195	12.9166	45.4751	2.07255	4.42169	4.76219
GO:0030410	nicotianamine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.458381	0.165789	0.19869
GO:0030418	nicotianamine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.458381	0.165789	0.19869
GO:0030420	establishment of competence for transformation	biological_process	Clostridium	Clostridium thermocellum	26.4095	282.329	361.857	180.511	165.892	181.106
GO:0030420	establishment of competence for transformation	biological_process	Escherichia	Escherichia coli	0.201602	0	0.187552	0	0	0
GO:0030435	sporulation resulting in formation of a cellular spore	biological_process	Clostridium	Clostridium thermocellum	79.6942	328.256	169.846	1262.16	1104.35	1594.63
GO:0030435	sporulation resulting in formation of a cellular spore	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	225.31	404.169	315.996	283.672	335.978	603.333
GO:0030436	asexual sporulation	biological_process	Clostridium	Clostridium thermocellum	1.06843	21.4712	7.272	53.8536	45.1479	49.5785
GO:0030497	fatty acid elongation	biological_process	Clostridium	Clostridium thermocellum	1.23664	9.73149	5.3981	27.9807	25.9851	38.4535
GO:0030497	fatty acid elongation	biological_process	Escherichia	Escherichia coli	0	0	0.150204	0	0	0
GO:0030515	snoRNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	4.51064	3.85666	1.44687	0
GO:0030541	plasmid partitioning	biological_process	Escherichia	Escherichia coli	0.0836546	0	0	0	0	0
GO:0030573	bile acid catabolic process	biological_process	Escherichia	Escherichia coli	0.157247	0	0	0	0	0
GO:0030599	pectinesterase activity	molecular_function	Clostridium	Clostridium thermocellum	0.218955	0.150196	0.203159	0.495139	0.349135	0.332929
GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	molecular_function	Clostridium	Clostridium thermocellum	1.5856	8.00737	3.75655	20.4672	19.2295	15.9648
GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	4.67053	4.78465	2.16822	5.04796	4.35649	2.48715
GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	molecular_function	Escherichia	Escherichia coli	0.0464207	0	0	0	0	0
GO:0030632	D-alanine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.852732	8.32088	5.31565	23.5014	22.1396	20.8272
GO:0030632	D-alanine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.03638	4.11012	2.81549	4.96229	3.96708	5.04632
GO:0030632	D-alanine biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0969003	0	0	0	0	0
GO:0030643	cellular phosphate ion homeostasis	biological_process	Clostridium	Clostridium thermocellum	0.873002	8.92465	7.92108	11.9012	13.2486	11.9292
GO:0030643	cellular phosphate ion homeostasis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	134.535	172.094	104.632	117.972	146.035	117.723
GO:0030643	cellular phosphate ion homeostasis	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.112378
GO:0030643	cellular phosphate ion homeostasis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.111434	0.184127	1.56966	0.754758	0.256333	0.805659
GO:0030655	beta-lactam antibiotic catabolic process	biological_process	Clostridium	Clostridium thermocellum	133936	95932	83193.2	37667.8	49698.2	17083.2
GO:0030655	beta-lactam antibiotic catabolic process	biological_process	Escherichia	Escherichia coli	77927.6	0	34222.8	0	0	7845.05
GO:0030674	protein binding, bridging	molecular_function	Escherichia	Escherichia coli	0.0814915	0	0.0755531	0	0	0
GO:0030697	S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0511114	0	0	0	0	0
GO:0030698	5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.54783	8.23481	3.57378	33.2139	32.0653	25.7839
GO:0030698	5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.3952	25.0556	21.3114	16.3395	17.3561	16.2648
GO:0030699	glycine reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	149.417	194.567	244.91	115.624	154.387	113.778
GO:0030788	precorrin-2 C20-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.177006	0.170032	0	0.226492	0.513556	0.471145
GO:0030798	trans-aconitate 2-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0798145	0	0	0	0	0
GO:0030955	potassium ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	82.4715	172.006	221.728	91.3702	114.013	90.918
GO:0030955	potassium ion binding	molecular_function	Escherichia	Escherichia coli	0.183884	0	0	0	0	0
GO:0030961	peptidyl-arginine hydroxylation	biological_process	Escherichia	Escherichia coli	0.0500177	0	0	0	0	0
GO:0030976	thiamine pyrophosphate binding	molecular_function	Clostridium	Clostridium thermocellum	34.6043	296.207	197.136	815.991	684.099	659
GO:0030976	thiamine pyrophosphate binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	140.286	75.2662	108.498	40.4161	49.8643	52.1933
GO:0030976	thiamine pyrophosphate binding	molecular_function	Escherichia	Escherichia coli	0.213511	0	0.225667	0	0	0.0616379
GO:0030976	thiamine pyrophosphate binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.942924	1.45645	1.49627	1.39118	0.732539	0.439162
GO:0030980	alpha-glucan catabolic process	biological_process	Escherichia	Escherichia coli	0.168573	0	0.129139	0	0	0
GO:0030983	mismatched DNA binding	molecular_function	Clostridium	Clostridium thermocellum	2.98984	19.5161	13.0179	52.0287	52.5978	53.8572
GO:0030983	mismatched DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	34.6387	33.8197	30.2089	39.5389	47.3924	42.4149
GO:0030983	mismatched DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.135471	1.14467	1.00474	0.277252	0.241922	0.342437
GO:0031071	cysteine desulfurase activity	molecular_function	Clostridium	Clostridium thermocellum	3.91947	55.9324	51.6661	114.788	99.4343	130.863
GO:0031071	cysteine desulfurase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.138023	0.0884932	0.0854314	0.118083	0.0412138	0.122855
GO:0031119	tRNA pseudouridine synthesis	biological_process	Clostridium	Clostridium thermocellum	1.44257	11.3463	8.44567	28.0432	29.1417	20.7401
GO:0031119	tRNA pseudouridine synthesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.964506	0.884605	0.57055	1.30193	0.757714	0.359253
GO:0031119	tRNA pseudouridine synthesis	biological_process	Escherichia	Escherichia coli	0.133186	0	0	0	0	0
GO:0031119	tRNA pseudouridine synthesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.752551	0.87625	0.922425	0.569526	0.745864	0.887056
GO:0031154	culmination involved in sorocarp development	biological_process	Escherichia	Escherichia coli	0.0403933	0	0.0750119	0	0	0
GO:0031167	rRNA methylation	biological_process	Clostridium	Clostridium thermocellum	2.10947	15.9748	14.7093	39.1462	36.2457	56.1881
GO:0031167	rRNA methylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.26581	1.00339	2.54012	1.33674	1.74978	2.77348
GO:0031167	rRNA methylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0615379	0.236635	0.11439	0.0630458	0	0.0819791
GO:0031176	endo-1,4-beta-xylanase activity	molecular_function	Clostridium	Clostridium thermocellum	39.2754	60.4228	57.7899	127.287	102.867	96.3288
GO:0031218	arabinogalactan endo-1,4-beta-galactosidase activity	molecular_function	Clostridium	Clostridium thermocellum	1.0845	6.84132	6.44917	14.4016	15.454	20.6395
GO:0031220	maltodextrin phosphorylase activity	molecular_function	Escherichia	Escherichia coli	0.0643814	0	0.0803795	0	0	0
GO:0031222	arabinan catabolic process	biological_process	Clostridium	Clostridium thermocellum	0.249773	2.9802	2.21887	5.951	5.87756	6.05251
GO:0031280	negative regulation of cyclase activity	biological_process	Escherichia	Escherichia coli	0.108493	0	0	0	0	0
GO:0031297	replication fork processing	biological_process	Escherichia	Escherichia coli	0.0241582	0	0	0	0	0
GO:0031388	organic acid phosphorylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	42.8886	9.93042	11.9993	14.1016	15.5978	11.3916
GO:0031388	organic acid phosphorylation	biological_process	Escherichia	Escherichia coli	0.0976051	0	0	0	0	0.129873
GO:0031402	sodium ion binding	molecular_function	Escherichia	Escherichia coli	0.200047	0	0	0	0	0
GO:0031418	L-ascorbic acid binding	molecular_function	Escherichia	Escherichia coli	0.0692422	0	0	0	0	0
GO:0031419	cobalamin binding	molecular_function	Clostridium	Clostridium thermocellum	8.41394	130.346	127.939	169.82	136.309	98.5787
GO:0031419	cobalamin binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	144.278	89.4375	110.055	81.7648	101.578	70.7379
GO:0031419	cobalamin binding	molecular_function	Escherichia	Escherichia coli	0.0381088	0	0.0127651	0	0	0.0549114
GO:0031419	cobalamin binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.84983	1.92543	2.22374	1.59718	0.781131	1.3366
GO:0031460	glycine betaine transport	biological_process	Escherichia	Escherichia coli	0.328907	0	0.042851	0	0	0
GO:0031564	transcription antitermination	biological_process	Clostridium	Clostridium thermocellum	12.7564	60.6285	41.9023	224.412	224.981	181.282
GO:0031564	transcription antitermination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	73.3022	109.531	86.4041	101.71	134.323	109.123
GO:0031564	transcription antitermination	biological_process	Escherichia	Escherichia coli	0.0795229	0	0	0	0	0.0241572
GO:0031669	cellular response to nutrient levels	biological_process	Escherichia	Escherichia coli	0.25614	0	0	0	0	0
GO:0031956	medium-chain fatty acid-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0767036	0	0	0	0	0.0216994
GO:0031992	energy transducer activity	molecular_function	Escherichia	Escherichia coli	0.0426293	0	0	0	0	0
GO:0032026	response to magnesium ion	biological_process	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0032049	cardiolipin biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.139359	3.14249	2.90972	4.88365	5.64617	5.83995
GO:0032049	cardiolipin biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0368206	0	0.0826348	0	0	0.0296224
GO:0032135	DNA insertion or deletion binding	molecular_function	Escherichia	Escherichia coli	0.315175	0	0	0	0	0
GO:0032196	transposition	biological_process	Escherichia	Escherichia coli	1.22062	0	0.559229	0	0	0.106039
GO:0032238	adenosine transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0032259	methylation	biological_process	Escherichia	Escherichia coli	0.0764849	0	0	0	0	0
GO:0032264	IMP salvage	biological_process	Escherichia	Escherichia coli	0.125603	0	0.23311	0	0	0.309904
GO:0032264	IMP salvage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.634761	0.307761	0.0564054	0.0984227	0
GO:0032297	negative regulation of DNA-dependent DNA replication initiation	biological_process	Escherichia	Escherichia coli	0.12276	0	0.227832	0	0	0
GO:0032324	molybdopterin cofactor biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	85.9615	34.4384	28.4195	35.6175	36.5763	25.4597
GO:0032324	molybdopterin cofactor biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.045643	0.262912	0.253543	0.326694	0.304774	0.455429
GO:0032450	maltose alpha-glucosidase activity	molecular_function	Escherichia	Escherichia coli	0.016867	0	0	0	0	0
GO:0032467	positive regulation of cytokinesis	biological_process	Escherichia	Escherichia coli	0.0424106	0	0	0	0	0
GO:0032508	DNA duplex unwinding	biological_process	Escherichia	Escherichia coli	0.234704	0	0.0936859	0	0	0.0384186
GO:0032543	mitochondrial translation	biological_process	Escherichia	Escherichia coli	0.0469554	0	0	0	0	0
GO:0032549	ribonucleoside binding	molecular_function	Clostridium	Clostridium thermocellum	4.13446	16.721800000000002	9.551	60.1148	58.1994	51.541
GO:0032549	ribonucleoside binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	30.8268	15.7939	11.9398	13.5998	14.9322	7.92765
GO:0032549	ribonucleoside binding	molecular_function	Escherichia	Escherichia coli	0.0313279	0	0.0232749	0	0	0.0166869
GO:0032549	ribonucleoside binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0438688	0.441299	0.490441	0.833547	0.23832	0.189021
GO:0032775	DNA methylation on adenine	biological_process	Escherichia	Escherichia coli	0.0768494	0	0.071268	0	0	0
GO:0032781	positive regulation of ATPase activity	biological_process	Escherichia	Escherichia coli	0.0933276	0	0	0	0	0
GO:0032784	regulation of DNA-templated transcription, elongation	biological_process	Clostridium	Clostridium thermocellum	14.6136	76.1035	52.063	280.642	256.965	244.417
GO:0032784	regulation of DNA-templated transcription, elongation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	115.488	151.304	113.504	211.533	241.643	188.773
GO:0032784	regulation of DNA-templated transcription, elongation	biological_process	Escherichia	Escherichia coli	0.351534	0	0	0	0	0
GO:0032955	regulation of barrier septum assembly	biological_process	Clostridium	Clostridium thermocellum	15.7858	124.745	96.0914	298.916	275.98	215.301
GO:0032955	regulation of barrier septum assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	41.0953	64.2831	64.2589	61.723	73.4074	44.1752
GO:0032955	regulation of barrier septum assembly	biological_process	Escherichia	Escherichia coli	0.415453	0	0	0	0	0
GO:0032973	amino acid export	biological_process	Escherichia	Escherichia coli	0.162035	0	0	0	0	0.215603
GO:0033094	butane-1,4-diamine:2-oxoglutarate aminotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	176.201	53.7552	61.3663	40.5953	46.613	27.8041
GO:0033094	butane-1,4-diamine:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0567224
GO:0033212	iron assimilation	biological_process	Escherichia	Escherichia coli	0	0	0.198062	0	0	0
GO:0033228	cysteine export	biological_process	Escherichia	Escherichia coli	0.090168	0	0.0573753	0	0	0.0861185
GO:0033362	lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway	biological_process	Clostridium	Clostridium thermocellum	0.112212	6.54863	14.2787	14.7861	20.8913	21.728
GO:0033362	lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0448896	0.129286	0.499643	0.0459351	0.0400853	0.0298488
GO:0033384	geranyl diphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.129589	0	0	0	0	0
GO:0033387	putrescine biosynthetic process from ornithine	biological_process	Escherichia	Escherichia coli	0.0726691	0	0.0220119	0	0	0
GO:0033388	putrescine biosynthetic process from arginine	biological_process	Clostridium	Clostridium thermocellum	1.78679	13.4693	13.2085	36.5505	39.1243	37.5637
GO:0033499	galactose catabolic process via UDP-galactose	biological_process	Escherichia	Escherichia coli	0.0545626	0	0	0	0	0
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	biological_process	Escherichia	Escherichia coli	0.12327	0	0.0611642	0	0	0
GO:0033543	fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway	biological_process	Escherichia	Escherichia coli	0.039008	0	0.144836	0	0	0
GO:0033554	cellular response to stress	biological_process	Clostridium	Clostridium thermocellum	3.384	11.554	11.2844	33.3054	26.5787	30.8817
GO:0033554	cellular response to stress	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	14.3745	14.8853	9.86895	18.6179	26.4482	29.9665
GO:0033554	cellular response to stress	biological_process	Escherichia	Escherichia coli	0.509097	0	1.91711	0	0	0
GO:0033567	DNA replication, Okazaki fragment processing	biological_process	Escherichia	Escherichia coli	0.0401017	0	0	0	0	0
GO:0033592	RNA strand annealing activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.027294
GO:0033608	formyl-CoA transferase activity	molecular_function	Escherichia	Escherichia coli	0.0441605	0	0	0	0	0
GO:0033611	oxalate catabolic process	biological_process	Escherichia	Escherichia coli	0.0441605	0	0	0	0	0.0418465
GO:0033680	ATP-dependent DNA/RNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.0579166	0	0.0179072	0	0	0.0256771
GO:0033721	aldehyde dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.0479276	0	0	0	0	0
GO:0033726	aldehyde ferredoxin oxidoreductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	209.021	34.6766	39.8562	70.1212	80.2354	39.5824
GO:0033739	preQ1 synthase activity	molecular_function	Escherichia	Escherichia coli	0.0694853	0	0.129049	0	0	0
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.85163	2.10927	1.80651	1.83144	1.68072	1.29517
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	molecular_function	Escherichia	Escherichia coli	0.36789	0	0.170863	0	0	0
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.158584	0	0	0.162278	0	0.106039
GO:0033748	hydrogenase (acceptor) activity	molecular_function	Escherichia	Escherichia coli	0.0312793	0	0.0465498	0	0	0
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	1.43953	0	0	0	0	0
GO:0033785	heptose 7-phosphate kinase activity	molecular_function	Escherichia	Escherichia coli	0.0189329	0	0.0702306	0	0	0
GO:0033786	heptose-1-phosphate adenylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0189329	0	0.0702306	0	0	0
GO:0033794	sarcosine reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.2407	35.7679	37.5771	30.153	31.4085	22.4047
GO:0033795	betaine reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.2407	35.7679	37.5771	30.153	31.4085	22.4047
GO:0033817	beta-ketoacyl-acyl-carrier-protein synthase II activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	66.4879	3.17819	4.16665	18.499	28.3962	21.9105
GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	molecular_function	Clostridium	Clostridium thermocellum	4.04767	19.5069	7.83488	91.367	62.7221	37.8774
GO:0033819	lipoyl(octanoyl) transferase activity	molecular_function	Escherichia	Escherichia coli	0.341083	0	0	0	0	0
GO:0033856	pyridoxine 5'-phosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0555582
GO:0033862	UMP kinase activity	molecular_function	Clostridium	Clostridium thermocellum	11.3218	67.1234	51.461	159.51	193.93	308.74
GO:0033862	UMP kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	31.9732	40.3057	29.2957	30.9004	30.1003	24.9502
GO:0033862	UMP kinase activity	molecular_function	Escherichia	Escherichia coli	0.0843837	0	0	0	0	0
GO:0033862	UMP kinase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0925984	0	0	0.236316	0.289365	0.123082
GO:0033883	pyridoxal phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0746134	0	0.138477	0	0	0.0419435
GO:0033897	ribonuclease T2 activity	molecular_function	Escherichia	Escherichia coli	0.0369908	0	0	0	0	0
GO:0033905	xylan endo-1,3-beta-xylosidase activity	molecular_function	Clostridium	Clostridium thermocellum	16.3941	19.9949	19.8209	38.1925	25.6185	20.6253
GO:0033971	hydroxyisourate hydrolase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.246875
GO:0033990	ectoine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.395184	0.94332	0	0	0	0.131458
GO:0034015	L-ribulose-5-phosphate 3-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0683187	0	0	0	0	0
GO:0034023	5-(carboxyamino)imidazole ribonucleotide mutase activity	molecular_function	Clostridium	Clostridium thermocellum	2.61281	3.63587	3.39479	26.268	33.4033	33.0155
GO:0034023	5-(carboxyamino)imidazole ribonucleotide mutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.53017	1.38868	0.939701	2.2926	2.8344	2.40446
GO:0034023	5-(carboxyamino)imidazole ribonucleotide mutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.224229	0.322981	0.312136	0.114751	0.175186	0.223753
GO:0034028	5-(carboxyamino)imidazole ribonucleotide synthase activity	molecular_function	Escherichia	Escherichia coli	0.0529585	0	0.0982867	0	0	0
GO:0034038	deoxyhypusine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.125603	0	0	0.28919	0	0.0417172
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.189038	0.0550169	0.0819791
GO:0034040	lipid-transporting ATPase activity	molecular_function	Escherichia	Escherichia coli	0.150977	0	0	0	0	0.040456
GO:0034194	D-galactonate catabolic process	biological_process	Escherichia	Escherichia coli	0.216379	0	0	0	0	0
GO:0034198	cellular response to amino acid starvation	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0362842
GO:0034200	D,D-heptose 1,7-bisphosphate phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.114108	0	0.21227	0	0	0
GO:0034213	quinolinate catabolic process	biological_process	Escherichia	Escherichia coli	0.0653293	0	0	0	0	0
GO:0034219	carbohydrate transmembrane transport	biological_process	Escherichia	Escherichia coli	0.699835	0	0.245965	0	0	0.108206
GO:0034220	ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.466103	0	0	0	0	0.102676
GO:0034224	cellular response to zinc ion starvation	biological_process	Escherichia	Escherichia coli	0.0484137	0	0	0	0	0
GO:0034227	tRNA thio-modification	biological_process	Clostridium	Clostridium thermocellum	1.60429	7.88873	6.48377	27.1068	28.7997	21.395
GO:0034227	tRNA thio-modification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.427095	0.271734	0.79518	0.582508	0.353779	0.573821
GO:0034257	nicotinamide riboside transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	0.0875918	4.78624	2.8431	6.88935	7.03481	9.66661
GO:0034567	chromate reductase activity	molecular_function	Escherichia	Escherichia coli	0.165389	0	0	0	0	0
GO:0034599	cellular response to oxidative stress	biological_process	Escherichia	Escherichia coli	0.0685131	0	0	0	0	0
GO:0034618	arginine binding	molecular_function	Clostridium	Clostridium thermocellum	1.71324	12.8289	13.414	29.8852	32.2591	32.9507
GO:0034618	arginine binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	58.4295	48.081	48.318600000000004	16.422	24.8708	34.0323
GO:0034618	arginine binding	molecular_function	Escherichia	Escherichia coli	0.234947	0	0.154985	0	0	0
GO:0034628	'de novo' NAD biosynthetic process from aspartate	biological_process	Escherichia	Escherichia coli	0.0653293	0	0	0	0	0
GO:0034639	L-amino acid efflux transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.162035	0	0	0	0	0.215603
GO:0034661	ncRNA catabolic process	biological_process	Escherichia	Escherichia coli	0.0135617	0	0	0	0	0.0352171
GO:0034700	allulose 6-phosphate 3-epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0890257	0	0	0	0	0
GO:0034775	glutathione transmembrane transport	biological_process	Escherichia	Escherichia coli	0.090168	0	0.0573753	0	0	0
GO:0034979	NAD-dependent protein deacetylase activity	molecular_function	Clostridium	Clostridium thermocellum	6.95135	45.9196	41.1006	72.7585	83.0025	129.835
GO:0034979	NAD-dependent protein deacetylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.0074	73.6862	90.1666	38.8953	49.7602	41.129
GO:0035312	5'-3' exodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0	0	0.116555	0	0	0.0883498
GO:0035344	hypoxanthine transport	biological_process	Escherichia	Escherichia coli	0.0803249	0	0	0	0	0.0530681
GO:0035350	FAD transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0959524	0	0	0	0	0.0780984
GO:0035368	selenocysteine insertion sequence binding	molecular_function	Escherichia	Escherichia coli	0.0286545	0	0	0	0	0
GO:0035429	gluconate transmembrane transport	biological_process	Escherichia	Escherichia coli	0.285791	0	0	0	0	0.164637
GO:0035435	phosphate ion transmembrane transport	biological_process	Clostridium	Clostridium thermocellum	0.234388	1.02869	0.931852	0.376733	0.179353	0.534271
GO:0035435	phosphate ion transmembrane transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	64.3583	11.8514	9.56327	18.2278	19.6262	11.0557
GO:0035435	phosphate ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.247148	0	0.446147	0	0	0
GO:0035435	phosphate ion transmembrane transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.265573	0.128418	0.10622	0.0618316	0
GO:0035438	cyclic-di-GMP binding	molecular_function	Clostridium	Clostridium thermocellum	182.668	464.075	616.926	1359.23	1402.17	1913.17
GO:0035438	cyclic-di-GMP binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	17.7769	64.669	52.0921	28.2876	34.1113	34.4956
GO:0035438	cyclic-di-GMP binding	molecular_function	Escherichia	Escherichia coli	0.0393726	0	0	0	0	0.24639
GO:0035442	dipeptide transmembrane transport	biological_process	Escherichia	Escherichia coli	0.217035	0	0	0	0	0.0780984
GO:0035444	nickel cation transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0848698	0	0.0220119	0	0	0
GO:0035527	3-hydroxypropionate dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0	0	0.151106	0	0	0
GO:0035556	intracellular signal transduction	biological_process	Escherichia	Escherichia coli	0	0	0.442223	0	0	0
GO:0035725	sodium ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.38189	0	0.0880025	0	0	0.212208
GO:0035998	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.75064	26.1507	22.8737	59.1885	55.363	59.7911
GO:0035998	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	21.0869	27.9668	16.4539	22.0763	24.8876	25.081
GO:0035999	tetrahydrofolate interconversion	biological_process	Clostridium	Clostridium thermocellum	9.03581	91.7583	67.1625	285.092	292.207	268.813
GO:0035999	tetrahydrofolate interconversion	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	149.569	51.323	89.7913	36.9756	52.1917	47.0604
GO:0035999	tetrahydrofolate interconversion	biological_process	Escherichia	Escherichia coli	0.130318	0	0.365136	0	0	0
GO:0036009	protein-glutamine N-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.69703	8.97286	6.41728	11.9222	13.9485	13.8792
GO:0036009	protein-glutamine N-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0036094	small molecule binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.912593	1.12829	1.69573	1.86282	1.3843	2.54177
GO:0036104	Kdo2-lipid A biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0942025	0	0	0	0	0
GO:0036108	4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0872827
GO:0036131	prostaglandin D2 11-ketoreductase activity	molecular_function	Escherichia	Escherichia coli	0.143394	0	0	0	0	0
GO:0036355	2-iminoacetate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	0.235895	3.02095	6.27362	2.49507	2.07163	1.83132
GO:0036355	2-iminoacetate synthase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0458281	0	0	0
GO:0036356	cyclic 2,3-diphosphoglycerate synthetase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.156226	0.374836	0.253588	0.199235	0.174296	0.363424
GO:0036361	racemase activity, acting on amino acids and derivatives	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	53.023	40.5321	36.5296	34.0965	36.1008	39.929
GO:0036361	racemase activity, acting on amino acids and derivatives	molecular_function	Escherichia	Escherichia coli	0.0447681	0	0	0	0	0
GO:0036374	glutathione hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0455458	0	0	0	0	0
GO:0036380	UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0765578	0	0.0472715	0	0	0
GO:0036381	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.996102	1.67288	1.284	2.39159	0.79411	2.81018
GO:0036439	glycerol-3-phosphate dehydrogenase [NADP+] activity	molecular_function	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0036439	glycerol-3-phosphate dehydrogenase [NADP+] activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.221021	0.396106	0	0
GO:0040008	regulation of growth	biological_process	Escherichia	Escherichia coli	0.0489484	0	0.0452868	0	0	0
GO:0042026	protein refolding	biological_process	Clostridium	Clostridium thermocellum	4.49499	69.5112	74.5146	100.37	105.77	104.092
GO:0042026	protein refolding	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	50.2588	66.8372	80.2765	34.749	48.1546	40.7722
GO:0042026	protein refolding	biological_process	Escherichia	Escherichia coli	0.0325674	0	0	0	0	0.0432048
GO:0042126	nitrate metabolic process	biological_process	Escherichia	Escherichia coli	0.033734	0	0	0	0	0
GO:0042128	nitrate assimilation	biological_process	Escherichia	Escherichia coli	0.887876	0	0.482954	0	0	0
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0870328	0	0	0	0	0
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.06735	0.260354	0.0717752	0.156587	0
GO:0042158	lipoprotein biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.97208	5.6224	2.38586	18.0107	13.9535	12.5643
GO:0042158	lipoprotein biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	45.9846	64.7185	78.0134	26.6446	31.0394	36.6187
GO:0042158	lipoprotein biosynthetic process	biological_process	Escherichia	Escherichia coli	0.101931	0	0	0	0	0
GO:0042168	heme metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0861531	0	0	0
GO:0042173	regulation of sporulation resulting in formation of a cellular spore	biological_process	Clostridium	Clostridium thermocellum	4.93358	18.9337	16.2534	63.1571	73.0955	145.364
GO:0042182	ketone catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0350877
GO:0042242	cobyrinic acid a,c-diamide synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.14247	0.234488	0.151106	0.208287	0.127222	0.0271
GO:0042244	spore wall assembly	biological_process	Clostridium	Clostridium thermocellum	0.109733	0.31598	0.33938	1.38467	1.63286	1.58095
GO:0042245	RNA repair	biological_process	Escherichia	Escherichia coli	0.112552	0	0.33505	0	0	0
GO:0042245	RNA repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0042254	ribosome biogenesis	biological_process	Clostridium	Clostridium thermocellum	15.3837	60.1888	32.9736	405.225	311.67	206.171
GO:0042254	ribosome biogenesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	73.1743	80.7309	66.0647	89.0777	108.378	94.9032
GO:0042254	ribosome biogenesis	biological_process	Escherichia	Escherichia coli	0.0475144	0	0	0	0	0.189668
GO:0042254	ribosome biogenesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.93103	8.44153	2.0946	4.04985	1.97499	4.878
GO:0042256	mature ribosome assembly	biological_process	Clostridium	Clostridium thermocellum	1.39243	22.0746	15.9619	51.3402	47.5091	73.1241
GO:0042256	mature ribosome assembly	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.65391	2.99453	3.27865	1.59564	2.6893	3.31622
GO:0042256	mature ribosome assembly	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.260895	0.430999	0.334377	0.436058
GO:0042274	ribosomal small subunit biogenesis	biological_process	Clostridium	Clostridium thermocellum	6.82691	38.931	27.5294	102.83	100.473	77.8864
GO:0042274	ribosomal small subunit biogenesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	28.1351	46.0887	41.1475	31.0127	35.2509	32.5146
GO:0042277	peptide binding	molecular_function	Escherichia	Escherichia coli	0.066666	0	0	0	0	0
GO:0042278	purine nucleoside metabolic process	biological_process	Escherichia	Escherichia coli	0.0852829	0	0	0	0	0
GO:0042279	nitrite reductase (cytochrome, ammonia-forming) activity	molecular_function	Escherichia	Escherichia coli	0.188502	0	0.139875	0	0	0
GO:0042286	glutamate-1-semialdehyde 2,1-aminomutase activity	molecular_function	Clostridium	Clostridium thermocellum	0.235652	6.17217	6.24254	13.548	10.6005	11.2315
GO:0042286	glutamate-1-semialdehyde 2,1-aminomutase activity	molecular_function	Escherichia	Escherichia coli	0.124024	0	0.0634195	0	0	0
GO:0042286	glutamate-1-semialdehyde 2,1-aminomutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.109174	0.0838725	0.121562	0.0893584	0.155979	0.232452
GO:0042301	phosphate ion binding	molecular_function	Escherichia	Escherichia coli	0.109077	0	0.202663	0	0	0
GO:0042355	L-fucose catabolic process	biological_process	Escherichia	Escherichia coli	0.0539064	0	0.0554808	0	0	0
GO:0042398	cellular modified amino acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0496775	0	0	0	0	0
GO:0042450	arginine biosynthetic process via ornithine	biological_process	Clostridium	Clostridium thermocellum	1.62409	2.70049	1.06591	12.8661	7.55014	6.66527
GO:0042450	arginine biosynthetic process via ornithine	biological_process	Escherichia	Escherichia coli	0.0416328	0	0.079748	0	0	0
GO:0042450	arginine biosynthetic process via ornithine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.193217	0.185668	0.179343	0.197842	0.120864	0.0257418
GO:0042493	response to drug	biological_process	Escherichia	Escherichia coli	0.678982	0	0.178802	0	0	0
GO:0042542	response to hydrogen peroxide	biological_process	Escherichia	Escherichia coli	0.198613	0	0.071674	0	0	0
GO:0042545	cell wall modification	biological_process	Clostridium	Clostridium thermocellum	0.218955	0.150196	0.203159	0.495139	0.349135	0.332929
GO:0042558	pteridine-containing compound metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.21198	0.0857394	0.124268	0.0228308	0.0398466	0.0594065
GO:0042558	pteridine-containing compound metabolic process	biological_process	Escherichia	Escherichia coli	0.0137561	0	0.0127651	0	0	0.0549114
GO:0042558	pteridine-containing compound metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	7.51892	2.33312	7.68946	5.3912	4.69493	6.11001
GO:0042577	lipid phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0042586	peptide deformylase activity	molecular_function	Clostridium	Clostridium thermocellum	3.26197	24.2374	17.2553	68.291	73.0949	91.074700000000007
GO:0042586	peptide deformylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	6.56953	11.5923	8.82682	10.5893	13.7341	15.6364
GO:0042586	peptide deformylase activity	molecular_function	Escherichia	Escherichia coli	0.197835	0	0.250611	0	0	0.513671
GO:0042602	riboflavin reductase (NADPH) activity	molecular_function	Escherichia	Escherichia coli	0.086012	0	0.23753	0	0	0
GO:0042623	ATPase activity, coupled	molecular_function	Escherichia	Escherichia coli	0.0375984	0	0.0348672	0	0	0
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	molecular_function	Clostridium	Clostridium thermocellum	15.7479	83.9402	64.7572	181.149	178.438	211.38
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	73.818	66.7374	77.9893	51.3728	54.2119	47.4494
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	molecular_function	Escherichia	Escherichia coli	0.275608	0	0.112991	0	0	0
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.368182	0	0.136672	0.0751824	0	0.293993
GO:0042732	D-xylose metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0769063	0	0	0
GO:0042742	defense response to bacterium	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0042744	hydrogen peroxide catabolic process	biological_process	Escherichia	Escherichia coli	0.0460319	0	0	0	0	0
GO:0042773	ATP synthesis coupled electron transport	biological_process	Clostridium	Clostridium thermocellum	6.02553	37.0278	21.7994	232.123	203.359	171.832
GO:0042773	ATP synthesis coupled electron transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	95.862	59.029	46.6078	82.6894	92.291	53.6019
GO:0042773	ATP synthesis coupled electron transport	biological_process	Escherichia	Escherichia coli	0.169156	0	0.0653591	0	0	0.106557
GO:0042773	ATP synthesis coupled electron transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.438265	0	0	0	0
GO:0042777	plasma membrane ATP synthesis coupled proton transport	biological_process	Clostridium	Clostridium thermocellum	39.0864	407.387	328.627	946.847	865.463	694.314
GO:0042777	plasma membrane ATP synthesis coupled proton transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	167.471	117.226	92.5601	112.581	148.865	126.627
GO:0042777	plasma membrane ATP synthesis coupled proton transport	biological_process	Escherichia	Escherichia coli	0.280274	0	0.376683	0	0	0
GO:0042777	plasma membrane ATP synthesis coupled proton transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.76062	0.488906	1.63768	1.46582	1.1552	1.68208
GO:0042781	3'-tRNA processing endoribonuclease activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0942025	0.241209	0.524361	0.321024	0	0.208812
GO:0042802	identical protein binding	molecular_function	Clostridium	Clostridium thermocellum	19.4642	29.2946	29.3989	79.9306	72.7924	81.907
GO:0042802	identical protein binding	molecular_function	Escherichia	Escherichia coli	1.71166	0	1.18499	0	0	0.583846
GO:0042802	identical protein binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.112917	0.216846	0.208346	0.461987	0.478897	0.651629
GO:0042803	protein homodimerization activity	molecular_function	Escherichia	Escherichia coli	0.0323973	0	0	0	0	0.112378
GO:0042803	protein homodimerization activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0476602	0.184127	1.33312	0.689474	0.256333	0.636106
GO:0042819	vitamin B6 biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.996102	1.67288	1.284	2.39159	0.79411	2.81018
GO:0042823	pyridoxal phosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.806992	4.3834	5.1142	9.48325	7.42947	10.5914
GO:0042823	pyridoxal phosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.07375	7.12706	5.74208	2.3601	3.26514	4.11351
GO:0042823	pyridoxal phosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.055875	0	0	0	0	0
GO:0042823	pyridoxal phosphate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.996102	1.67288	1.284	2.39159	0.79411	2.81018
GO:0042834	peptidoglycan binding	molecular_function	Escherichia	Escherichia coli	0.0633607	0	0	0	0	0
GO:0042838	D-glucarate catabolic process	biological_process	Escherichia	Escherichia coli	0.217886	0	0	0	0	0.129873
GO:0042840	D-glucuronate catabolic process	biological_process	Escherichia	Escherichia coli	1.49497	0	0	0	0	0
GO:0042843	D-xylose catabolic process	biological_process	Escherichia	Escherichia coli	0.0744919	0	0	0	0	0.0247716
GO:0042867	pyruvate catabolic process	biological_process	Escherichia	Escherichia coli	0.046445	0	0	0	0	0
GO:0042882	L-arabinose transport	biological_process	Clostridium	Clostridium thermocellum	0.899031	2.69643	3.67495	3.0391	3.53656	4.19044
GO:0042882	L-arabinose transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.518649	1.61411	2.1228	0.219578	0.28739	0.499668
GO:0042882	L-arabinose transport	biological_process	Escherichia	Escherichia coli	0.26331	0	0.262158	0	0	0.109467
GO:0042884	microcin transport	biological_process	Escherichia	Escherichia coli	0.0769709	0	0.214075	0	0	0
GO:0042888	molybdenum ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.106914	0	0	0	0	0
GO:0042906	xanthine transport	biological_process	Escherichia	Escherichia coli	0.0374282	0	0.0694638	0	0	0
GO:0042907	xanthine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0374282	0	0.0694638	0	0	0
GO:0042912	colicin transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0.117682	0	0	0
GO:0042914	colicin transport	biological_process	Escherichia	Escherichia coli	0.0426293	0	0	0	0	0
GO:0042925	benzoate transporter activity	molecular_function	Escherichia	Escherichia coli	0.0475144	0	0	0	0	0
GO:0042931	enterobactin transporter activity	molecular_function	Escherichia	Escherichia coli	0.0882966	0	0.0819582	0	0	0.0587598
GO:0042936	dipeptide transporter activity	molecular_function	Escherichia	Escherichia coli	0.115323	0	0.253047	0	0	0
GO:0042937	tripeptide transporter activity	molecular_function	Escherichia	Escherichia coli	0.0781618	0	0.218585	0	0	0
GO:0042938	dipeptide transport	biological_process	Escherichia	Escherichia coli	0.0402232	0	0	0	0	0
GO:0042939	tripeptide transport	biological_process	Escherichia	Escherichia coli	0.0347305	0	0	0	0	0
GO:0042942	D-serine transport	biological_process	Escherichia	Escherichia coli	0.098796	0	0	0	0	0
GO:0042945	D-serine transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.098796	0	0	0	0	0
GO:0042953	lipoprotein transport	biological_process	Escherichia	Escherichia coli	0.600091	0	0	0	0	0
GO:0042954	lipoprotein transporter activity	molecular_function	Escherichia	Escherichia coli	0.600091	0	0	0	0	0
GO:0042958	maltodextrin transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0408065	0	0	0	0	0
GO:0042972	licheninase activity	molecular_function	Clostridium	Clostridium thermocellum	1.13682	8.18688	5.5922	7.09522	7.08042	10.4741
GO:0043022	ribosome binding	molecular_function	Clostridium	Clostridium thermocellum	27.5289	152.981	146.049	415.092	385.992	382.287
GO:0043022	ribosome binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	118.63	120.893	91.2068	117.719	108.775	96.5542
GO:0043022	ribosome binding	molecular_function	Escherichia	Escherichia coli	0.108202	0	0.681061	0	0	0
GO:0043022	ribosome binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.299645	1.15242	0.260895	1.35169	0.69126	1.63324
GO:0043023	ribosomal large subunit binding	molecular_function	Clostridium	Clostridium thermocellum	2.44149	14.764	9.49006	44.2985	44.8502	38.8289
GO:0043023	ribosomal large subunit binding	molecular_function	Escherichia	Escherichia coli	1.15634	0	0	0	0	0
GO:0043024	ribosomal small subunit binding	molecular_function	Escherichia	Escherichia coli	0.0375984	0	0.0348672	0	0	0
GO:0043039	tRNA aminoacylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	27.0738	37.966	41.1948	36.6099	54.6363	39.6919
GO:0043086	negative regulation of catalytic activity	biological_process	Escherichia	Escherichia coli	0.180142	0	0.072937	0	0	0
GO:0043093	FtsZ-dependent cytokinesis	biological_process	Clostridium	Clostridium thermocellum	84.3489	514.78	368.702	1529.03	1554.37	1943.26
GO:0043093	FtsZ-dependent cytokinesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	156.589	152.124	188.689	119.405	144.955	121.273
GO:0043093	FtsZ-dependent cytokinesis	biological_process	Escherichia	Escherichia coli	0.32689	0	0.0662161	0	0	0.0949793
GO:0043093	FtsZ-dependent cytokinesis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	7.95292	10.0726	7.46988	3.24533	2.46094	4.63953
GO:0043094	cellular metabolic compound salvage	biological_process	Clostridium	Clostridium thermocellum	0.81263	4.4486	5.05268	10.4408	12.9069	10.716
GO:0043094	cellular metabolic compound salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	14.6687	10.4423	9.26466	12.7706	15.3251	11.6857
GO:0043094	cellular metabolic compound salvage	biological_process	Escherichia	Escherichia coli	0.180458	0	0	0	0	0.060215
GO:0043103	hypoxanthine salvage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.634761	0.307761	0.0564054	0.0984227	0
GO:0043115	precorrin-2 dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0182523	12.9279	7.92212	23.4066	22.693	32.3801
GO:0043115	precorrin-2 dehydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.38579	2.13658	1.4185	1.57299	1.49333	1.6443
GO:0043136	glycerol-3-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.180065	0	0	0.193645
GO:0043137	DNA replication, removal of RNA primer	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.232128	0	0.32251	0.475343	0.103718	0.0772576
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	molecular_function	Escherichia	Escherichia coli	0.136953	0	0.0470459	0	0	0.0384186
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	molecular_function	Clostridium	Clostridium thermocellum	1.90991	12.3852	7.99226	25.3602	28.2005	32.8534
GO:0043142	single-stranded DNA-dependent ATPase activity	molecular_function	Escherichia	Escherichia coli	0.0289947	0	0	0	0	0
GO:0043150	DNA synthesis involved in double-strand break repair via homologous recombination	biological_process	Escherichia	Escherichia coli	0.0735927	0	0	0	0	0
GO:0043164	Gram-negative-bacterium-type cell wall biogenesis	biological_process	Escherichia	Escherichia coli	0.0143151	0	0	0	0	0
GO:0043165	Gram-negative-bacterium-type cell outer membrane assembly	biological_process	Escherichia	Escherichia coli	0.350149	0	0.694818	0	0	0
GO:0043169	cation binding	molecular_function	Clostridium	Clostridium thermocellum	1.36577	4.09104	3.84514	25.4212	28.2393	28.5431
GO:0043169	cation binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	71.8698	13.8513	20.8748	10.7321	12.5328	16.2434
GO:0043169	cation binding	molecular_function	Escherichia	Escherichia coli	0.144876	0	0.498696	0	0	0
GO:0043171	peptide catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.49947	3.40423	4.12114	2.4798	3.00514	1.70061
GO:0043213	bacteriocin transport	biological_process	Escherichia	Escherichia coli	0.0230889	0	0.654358	0	0	0
GO:0043215	daunorubicin transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.391685	0.32851	0.1772	0	0.225143
GO:0043266	regulation of potassium ion transport	biological_process	Escherichia	Escherichia coli	0.208748	0	0.176185	0	0	0.0427844
GO:0043295	glutathione binding	molecular_function	Escherichia	Escherichia coli	0.0403933	0	0.0750119	0	0	0
GO:0043335	protein unfolding	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0547174
GO:0043335	protein unfolding	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.828574	2.49783	0.874477	1.07929	0.741198	1.43213
GO:0043365	[formate-C-acetyltransferase]-activating enzyme activity	molecular_function	Clostridium	Clostridium thermocellum	19.3677	128.33	125.145	326.89	276.162	251.047
GO:0043365	[formate-C-acetyltransferase]-activating enzyme activity	molecular_function	Escherichia	Escherichia coli	0.1973	0	0.120299	0	0	0
GO:0043419	urea catabolic process	biological_process	Clostridium	Clostridium thermocellum	0.0309634	0.628694	1.87584	1.02724	1.13578	2.2221
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological_process	Escherichia	Escherichia coli	0.0888556	0	0.0854314	0	0	0.0304632
GO:0043462	regulation of ATPase activity	biological_process	Escherichia	Escherichia coli	0	0	0.835325	0	0	0
GO:0043470	regulation of carbohydrate catabolic process	biological_process	Escherichia	Escherichia coli	0.068659	0	0	0	0	0
GO:0043488	regulation of mRNA stability	biological_process	Escherichia	Escherichia coli	0.16534	0	0	0	0	0
GO:0043492	ATPase activity, coupled to movement of substances	molecular_function	Escherichia	Escherichia coli	0.0432126	0	0.214075	0	0	0
GO:0043531	ADP binding	molecular_function	Escherichia	Escherichia coli	0.0324945	0	0	0	0	0.0418465
GO:0043546	molybdopterin cofactor binding	molecular_function	Escherichia	Escherichia coli	0.128252	0	0	0	0	0.0230576
GO:0043565	sequence-specific DNA binding	molecular_function	Clostridium	Clostridium thermocellum	16.3948	223.15	153.314	270.899	253.281	279.903
GO:0043565	sequence-specific DNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	24.3213	16.6139	14.0454	23.2988	30.4672	32.9608
GO:0043565	sequence-specific DNA binding	molecular_function	Escherichia	Escherichia coli	4.04643	0	3.42208	0	0	0.861831
GO:0043565	sequence-specific DNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.65093	8.86467	3.05429	4.25921	1.93126	5.45939
GO:0043571	maintenance of CRISPR repeat elements	biological_process	Clostridium	Clostridium thermocellum	8.10355	3.93972	1.40096	17.8139	13.038	20.0466
GO:0043571	maintenance of CRISPR repeat elements	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.5248	2.45653	1.18021	1.52713	3.02595	2.5506
GO:0043571	maintenance of CRISPR repeat elements	biological_process	Escherichia	Escherichia coli	0.0633364	0	0.374338	0	0	0
GO:0043571	maintenance of CRISPR repeat elements	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.442625	0.479618	0.358009	0.029098	0.745387	0.151152
GO:0043621	protein self-association	molecular_function	Escherichia	Escherichia coli	0.0255679	0	0	0	0	0
GO:0043687	post-translational protein modification	biological_process	Escherichia	Escherichia coli	0.0500177	0	0	0	0	0
GO:0043708	cell adhesion involved in biofilm formation	biological_process	Escherichia	Escherichia coli	0.0270747	0	0.0635097	0	0	0.0755436
GO:0043709	cell adhesion involved in single-species biofilm formation	biological_process	Escherichia	Escherichia coli	0.237767	0	0.0414076	0	0	0.251952
GO:0043711	pilus organization	biological_process	Escherichia	Escherichia coli	0.912131	0	0.704742	0	0	0.104067
GO:0043714	(R)-citramalate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0362373	0.139181	0.0672536	0.222513	0	0.192837
GO:0043726	5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.114885	0	0.131891	0	0	0
GO:0043737	deoxyribonuclease V activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.41664	5.77819	4.71772	5.81506	8.1438	8.24891
GO:0043740	GTP cyclohydrolase IIa activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.526596	0.388931	0.751788	0.828871	0.469695	2.42383
GO:0043752	adenosylcobinamide kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.176107	3.3816	2.72149	10.0231	7.27764	13.1028
GO:0043755	alpha-ribazole phosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	0.550997	2.53531	1.5333	6.70068	5.21243	4.3977
GO:0043761	archaetidylserine synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.22575	1.77486	1.71368	1.3061	1.02104	1.75351
GO:0043765	T/G mismatch-specific endonuclease activity	molecular_function	Escherichia	Escherichia coli	0.150029	0	0	0	0	0
GO:0043766	Sep-tRNA:Cys-tRNA synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.320984	0.664072	0.412452	0.379046	0.154329	0.262915
GO:0043768	S-ribosylhomocysteine lyase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.492967	0	0	0
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.9589	11.5427	11.783	46.3819	56.3684	42.4494
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	299.256	99.4498	85.1809	76.2499	85.699	83.538
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.103876	0	0	0	0	0
GO:0043773	coenzyme F420-0 gamma-glutamyl ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159629	0.229914	0.147994	0.366486	0.14248	0.265502
GO:0043781	cobalt-factor II C20-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.177006	0.170032	0	0.226492	0.513556	0.471145
GO:0043801	hexulose-6-phosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0453757	0.172926	0.0842136	0.742945	0.162121	0.332153
GO:0043805	indolepyruvate ferredoxin oxidoreductase activity	molecular_function	Clostridium	Clostridium thermocellum	2.93977	15.4651	10.6259	35.8904	33.2201	36.3226
GO:0043805	indolepyruvate ferredoxin oxidoreductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	134.735	51.7516	89.4588	11.298400000000001	20.3181	42.559
GO:0043805	indolepyruvate ferredoxin oxidoreductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.193801	0.211665	1.02649	1.18665	0.174708	0.591543
GO:0043807	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	108.699	61.6366	47.053	58.4475	66.6334	93.9611
GO:0043807	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0541494	0.156077	0.652057	0.663609	0.313477	0
GO:0043814	phospholactate guanylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.465325	0	0.172802	0.238231	0	0
GO:0043815	phosphoribosylglycinamide formyltransferase 2 activity	molecular_function	Escherichia	Escherichia coli	0	0	0.26297	0	0	0.124181
GO:0043817	phosphosulfolactate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.232565	0.595509	0.863065	1.54662	0.415307	0.670579
GO:0043821	propionyl-CoA:succinate CoA-transferase activity	molecular_function	Escherichia	Escherichia coli	0.0623156	0	0	0	0	0.0829169
GO:0043825	succinylornithine transaminase activity	molecular_function	Escherichia	Escherichia coli	0.0680757	0	0	0	0	0
GO:0043838	phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity	molecular_function	Escherichia	Escherichia coli	0.0630447	0	0	0	0	0
GO:0043884	CO-methylating acetyl-CoA synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.039421200000000003	0	0	0	0.0704043	0.0524537
GO:0043887	melibiose:sodium symporter activity	molecular_function	Escherichia	Escherichia coli	0.142252	0	0.0880025	0	0	0.212208
GO:0043917	ribose 1,5-bisphosphate isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.222333	0.573012	0.41146	0.532295	0.266599	0.446632
GO:0043934	sporulation	biological_process	Clostridium	Clostridium thermocellum	0.109733	0.31598	0.33938	1.38467	1.63286	1.58095
GO:0043937	regulation of sporulation	biological_process	Clostridium	Clostridium thermocellum	0.816179	4.93041	4.15096	24.8279	21.9791	19.7016
GO:0043952	protein transport by the Sec complex	biological_process	Clostridium	Clostridium thermocellum	13.7304	31.2207	19.5836	185.679	124.807	93.6323
GO:0043952	protein transport by the Sec complex	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	81.4106	70.5303	67.6728	60.1239	70.9404	61.7074
GO:0043952	protein transport by the Sec complex	biological_process	Escherichia	Escherichia coli	0.111458	0	0.283087	0	0	0.0273587
GO:0043953	protein transport by the Tat complex	biological_process	Escherichia	Escherichia coli	0.621406	0	0	0	0	0
GO:0043957	acryloyl-CoA reductase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.117777	0	0.21845	0	0	0
GO:0044010	single-species biofilm formation	biological_process	Escherichia	Escherichia coli	0.214726	0	0.526166	0	0	1.27302
GO:0044036	cell wall macromolecule metabolic process	biological_process	Escherichia	Escherichia coli	0.0143151	0	0	0	0	0
GO:0044038	cell wall macromolecule biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0765578	0	0.0472715	0	0	0
GO:0044092	negative regulation of molecular function	biological_process	Escherichia	Escherichia coli	0.168767	0	0	0	0	0
GO:0044179	hemolysis in other organism	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0424286
GO:0044183	protein binding involved in protein folding	molecular_function	Escherichia	Escherichia coli	0.702582	0	0.704742	0	0	0
GO:0044205	'de novo' UMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.99385	32.0568	27.8071	93.7942	102.431	103.234
GO:0044205	'de novo' UMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.9763	7.93176	8.68739	2.85556	3.98222	3.30685
GO:0044205	'de novo' UMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.234145	0	0.0147047	0	0	0
GO:0044205	'de novo' UMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.28852	4.17673	2.82659	2.96541	2.36777	3.1826
GO:0044206	UMP salvage	biological_process	Clostridium	Clostridium thermocellum	10.1241	63.2315	62.446	131.224	128.121	141.808
GO:0044206	UMP salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	24.2382	38.2105	32.2957	22.7568	21.5793	23.6577
GO:0044206	UMP salvage	biological_process	Escherichia	Escherichia coli	0.0792312	0	0	0	0	0.105683
GO:0044206	UMP salvage	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0975079	0	0.179027	0.149818	0.130738	0
GO:0044208	'de novo' AMP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.47798	25.0905	23.5623	91.833	104.184	82.8417
GO:0044208	'de novo' AMP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	33.6181	21.2865	17.5166	22.9178	27.6806	22.5992
GO:0044208	'de novo' AMP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.103268	0	0	0	0	0
GO:0044208	'de novo' AMP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.288538	0.457168	1.33862	1.72706	0.84025	1.21901
GO:0044209	AMP salvage	biological_process	Clostridium	Clostridium thermocellum	9.88801	36.4396	19.4887	142.417	93.9552	92.2094
GO:0044209	AMP salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	82.9271	58.608	43.511	37.0193	45.5653	50.1944
GO:0044209	AMP salvage	biological_process	Escherichia	Escherichia coli	0.147307	0	0.224404	0	0	0
GO:0044210	'de novo' CTP biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	14.3125	84.6314	61.1861	206.548	245.317	356.629
GO:0044210	'de novo' CTP biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	113.73	71.2217	63.299	59.6361	65.3162	43.5671
GO:0044210	'de novo' CTP biosynthetic process	biological_process	Escherichia	Escherichia coli	0.247707	0	0	0	0	0
GO:0044210	'de novo' CTP biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.226489	0.514297	0.186334	0.818675	0.379063	0.523955
GO:0044211	CTP salvage	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	10.1265	24.3598	14.7753	15.3747	16.4329	16.4033
GO:0044212	transcription regulatory region DNA binding	molecular_function	Escherichia	Escherichia coli	0.423012	0	0.411956	0	0	0.379206
GO:0044237	cellular metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.47532	8.33493	8.53972	5.25356	5.34	5.49489
GO:0044238	primary metabolic process	biological_process	Clostridium	Clostridium thermocellum	57.9763	215.103	127.475	832.845	569.085	772.994
GO:0044238	primary metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	42.0218	42.5692	90.504	38.8777	52.7804	48.8106
GO:0044260	cellular macromolecule metabolic process	biological_process	Clostridium	Clostridium thermocellum	0	0	0.267977	0	0.0645879	0.240537
GO:0044262	cellular carbohydrate metabolic process	biological_process	Escherichia	Escherichia coli	0.0890257	0	0.0933701	0	0	0
GO:0044281	small molecule metabolic process	biological_process	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:0044283	small molecule biosynthetic process	biological_process	Escherichia	Escherichia coli	0.143856	0	0.138477	0	0	0.0419435
GO:0044318	L-aspartate:fumarate oxidoreductase activity	molecular_function	Clostridium	Clostridium thermocellum	2.029	11.9143	6.784	25.377	25.8602	20.0365
GO:0044318	L-aspartate:fumarate oxidoreductase activity	molecular_function	Escherichia	Escherichia coli	0.0330049	0	0	0	0	0
GO:0044349	DNA excision	biological_process	Escherichia	Escherichia coli	1.42047	0	0	0	0	0
GO:0044571	[2Fe-2S] cluster assembly	biological_process	Clostridium	Clostridium thermocellum	3.91947	55.9324	51.6661	114.788	99.4343	130.863
GO:0044610	FMN transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.0959524	0	0	0	0	0.0780984
GO:0044667	(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity	molecular_function	Escherichia	Escherichia coli	0.0349249	0	0	0	0	0
GO:0044689	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.120913	0.263659	0.169871	0.81472	0.656687	1.09606
GO:0044718	siderophore transmembrane transport	biological_process	Escherichia	Escherichia coli	0	0	0.117682	0	0	0
GO:0044780	bacterial-type flagellum assembly	biological_process	Clostridium	Clostridium thermocellum	33.414	88.8166	65.5319	967.809	899.021	747.531
GO:0044780	bacterial-type flagellum assembly	biological_process	Escherichia	Escherichia coli	0.190665	0	0.386697	0	0	0.0924892
GO:0044781	bacterial-type flagellum organization	biological_process	Clostridium	Clostridium thermocellum	15.7928	45.6453	37.7114	405.282	394.889	280.533
GO:0044781	bacterial-type flagellum organization	biological_process	Escherichia	Escherichia coli	0.0825852	0	0	0	0	0
GO:0044822	poly(A) RNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.45856	0.187441	1.44701	1.9968	1.30741	2.72633
GO:0045127	N-acetylglucosamine kinase activity	molecular_function	Escherichia	Escherichia coli	0.0637981	0	0	0	0	0.0424286
GO:0045148	tripeptide aminopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.49947	3.40423	4.12114	2.4798	3.00514	1.70061
GO:0045150	acetoin catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	115.779	6.00386	9.3934	2.61932	4.8924	1.93923
GO:0045226	extracellular polysaccharide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.49648	43.6705	36.7416	84.3769	98.3134	155.723
GO:0045226	extracellular polysaccharide biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.26015	1.99964	4.92832	0.722029	1.58891	1.92271
GO:0045226	extracellular polysaccharide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.599459	0	0.25873	0	0	0.134045
GO:0045226	extracellular polysaccharide biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.210813	0.0640362	0.72522	0.15989	0.20162	0.387873
GO:0045227	capsule polysaccharide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	3.00262	16.584	8.70638	40.1594	35.961	49.9037
GO:0045227	capsule polysaccharide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.349419	0	0	0	0	0
GO:0045228	slime layer polysaccharide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.232954	0	0.37745	0	0	0
GO:0045330	aspartyl esterase activity	molecular_function	Clostridium	Clostridium thermocellum	0.218955	0.150196	0.203159	0.495139	0.349135	0.332929
GO:0045333	cellular respiration	biological_process	Escherichia	Escherichia coli	0.0717456	0	0.122734	0	0	0.0111569
GO:0045337	farnesyl diphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.129589	0	0	0	0	0
GO:0045437	uridine nucleosidase activity	molecular_function	Escherichia	Escherichia coli	0.153577	0	0	0	0	0
GO:0045454	cell redox homeostasis	biological_process	Clostridium	Clostridium thermocellum	75.2534	772.464	610.22	1880.1	1429.21	2212.82
GO:0045454	cell redox homeostasis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	75.4945	173.534	241.865	130.534	149.926	105.491
GO:0045454	cell redox homeostasis	biological_process	Escherichia	Escherichia coli	0.953399	0	0.750344	0	0	0.0517099
GO:0045454	cell redox homeostasis	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	2.08901	6.07896	3.93481	3.80195	1.70492	2.5984
GO:0045471	response to ethanol	biological_process	Escherichia	Escherichia coli	0.269994	0	0.200453	0	0	0
GO:0045490	pectin catabolic process	biological_process	Clostridium	Clostridium thermocellum	0.218955	0.150196	0.203159	0.495139	0.349135	0.332929
GO:0045490	pectin catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0656748	0	0	0
GO:0045493	xylan catabolic process	biological_process	Clostridium	Clostridium thermocellum	29.2106	51.6523	53.1545	97.1435	79.9208	78.4948
GO:0045493	xylan catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.227778	0.058342	0	0	0.0135643	0
GO:0045550	geranylgeranyl reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.266154	1.40968	0.781738	1.31692	1.02676	1.37405
GO:0045717	negative regulation of fatty acid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.48606	19.529	5.98408	62.2942	58.1151	35.9727
GO:0045717	negative regulation of fatty acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.132044	0	0	0	0	0
GO:0045727	positive regulation of translation	biological_process	Clostridium	Clostridium thermocellum	1.05275	13.504	8.41166	25.5348	28.3919	30.655
GO:0045727	positive regulation of translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	3.84932	3.72544	2.99596	5.72677	5.91025	4.45378
GO:0045727	positive regulation of translation	biological_process	Escherichia	Escherichia coli	0.0817831	0	0.0622017	0	0	0
GO:0045828	positive regulation of isoprenoid metabolic process	biological_process	Escherichia	Escherichia coli	0.0932304	0	0	0	0	0
GO:0045862	positive regulation of proteolysis	biological_process	Escherichia	Escherichia coli	0.0281198	0	0	0	0	0
GO:0045892	negative regulation of transcription, DNA-templated	biological_process	Clostridium	Clostridium thermocellum	61.3857	237.87	183.623	1112.24	1159.02	1531.92
GO:0045892	negative regulation of transcription, DNA-templated	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	27.5553	51.8725	59.3377	36.2145	42.1951	41.0816
GO:0045892	negative regulation of transcription, DNA-templated	biological_process	Escherichia	Escherichia coli	1.98819	0	2.27895	0	0	0.404204
GO:0045893	positive regulation of transcription, DNA-templated	biological_process	Escherichia	Escherichia coli	2.81635	0	0.931942	0	0	1.34226
GO:0045901	positive regulation of translational elongation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.299645	1.15242	0	0.920692	0.356883	1.19719
GO:0045905	positive regulation of translational termination	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.299645	1.15242	0	0.920692	0.356883	1.19719
GO:0045910	negative regulation of DNA recombination	biological_process	Clostridium	Clostridium thermocellum	1.79646	9.59572	7.45549	24.5317	25.6271	27.6692
GO:0045910	negative regulation of DNA recombination	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	19.9673	19.013	15.8316	20.5905	25.004	19.1869
GO:0045936	negative regulation of phosphate metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.873002	8.92465	7.92108	11.9012	13.2486	11.9292
GO:0045936	negative regulation of phosphate metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	134.535	172.094	104.632	117.972	146.035	117.723
GO:0045936	negative regulation of phosphate metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.112378
GO:0045936	negative regulation of phosphate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.111434	0.184127	1.56966	0.754758	0.256333	0.805659
GO:0045947	negative regulation of translational initiation	biological_process	Escherichia	Escherichia coli	0.168767	0	0	0	0	0
GO:0045982	negative regulation of purine nucleobase metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.63228	13.8764	9.70138	49.8668	49.5821	67.5221
GO:0046026	precorrin-4 C11-methyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0830956	0.0797652	0	0.0849563	0.111293	0.0551701
GO:0046034	ATP metabolic process	biological_process	Clostridium	Clostridium thermocellum	0.844128	1.36483	0.989498	14.7573	12.6659	10.6787
GO:0046034	ATP metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0151414	0.116311	0.168608	0.123953	0.0946464	0.362616
GO:0046039	GTP metabolic process	biological_process	Clostridium	Clostridium thermocellum	1.23528	7.17098	4.74217	16.84	15.7692	21.3615
GO:0046039	GTP metabolic process	biological_process	Escherichia	Escherichia coli	0.0861822	0	0.159947	0	0	0
GO:0046080	dUTP metabolic process	biological_process	Clostridium	Clostridium thermocellum	4.346	16.0451	11.3653	45.9244	54.2822	67.5313
GO:0046080	dUTP metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.62402	13.6576	7.89036	6.861	7.59871	11.9597
GO:0046080	dUTP metabolic process	biological_process	Escherichia	Escherichia coli	0.0786479	0	0	0	0	0
GO:0046080	dUTP metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159119	0.308093	0	0	0.143261	0
GO:0046104	thymidine metabolic process	biological_process	Escherichia	Escherichia coli	0.0414384	0	0	0	0	0
GO:0046113	nucleobase catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	2.07992	3.38192	3.26796	1.73579	2.60042	1.87404
GO:0046113	nucleobase catabolic process	biological_process	Escherichia	Escherichia coli	0.0620482	0	0	0	0	0
GO:0046133	pyrimidine ribonucleoside catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.0567438	0	0	0.040844
GO:0046140	corrin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.581693	1.30481	0.516017	0.416077	0.164313	0.0683321
GO:0046167	glycerol-3-phosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0046167	glycerol-3-phosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0046167	glycerol-3-phosphate biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.221021	0.396106	0	0
GO:0046168	glycerol-3-phosphate catabolic process	biological_process	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0046168	glycerol-3-phosphate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.221021	0.396106	0	0
GO:0046176	aldonic acid catabolic process	biological_process	Escherichia	Escherichia coli	0.0899007	0	0	0	0	0
GO:0046177	D-gluconate catabolic process	biological_process	Escherichia	Escherichia coli	0.100206	0	0	0	0	0
GO:0046183	L-idonate catabolic process	biological_process	Escherichia	Escherichia coli	0.431421	0	0	0	0	0.128612
GO:0046214	enterobactin catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0307219
GO:0046256	2,4,6-trinitrotoluene catabolic process	biological_process	Escherichia	Escherichia coli	0.165389	0	0	0	0	0
GO:0046279	3,4-dihydroxybenzoate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.38574	7.35655	3.7173	17.0606	15.9985	19.0732
GO:0046294	formaldehyde catabolic process	biological_process	Escherichia	Escherichia coli	0.0710651	0	0	0	0	0
GO:0046296	glycolate catabolic process	biological_process	Escherichia	Escherichia coli	0.0297725	0	0.0829055	0	0	0.0197914
GO:0046316	gluconokinase activity	molecular_function	Escherichia	Escherichia coli	0.247318	0	0	0	0	0
GO:0046336	ethanolamine catabolic process	biological_process	Escherichia	Escherichia coli	0.0953205	0	0.27339	0	0	0.221715
GO:0046348	amino sugar catabolic process	biological_process	Escherichia	Escherichia coli	0.071381	0	0	0	0	0.0951734
GO:0046356	acetyl-CoA catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0396156	0	0.0734782	0.0405383	0	0
GO:0046365	monosaccharide catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0350877
GO:0046373	L-arabinose metabolic process	biological_process	Clostridium	Clostridium thermocellum	4.20574	10.9966	12.1554	20.5277	18.1504	28.5563
GO:0046386	deoxyribose phosphate catabolic process	biological_process	Clostridium	Clostridium thermocellum	2.09353	22.1003	15.1099	60.3665	37.74	60.8098
GO:0046386	deoxyribose phosphate catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	19.2405	14.345	7.7744	13.2134	16.1646	16.8584
GO:0046386	deoxyribose phosphate catabolic process	biological_process	Escherichia	Escherichia coli	0.0771654	0	0	0	0	0
GO:0046386	deoxyribose phosphate catabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.370175	0.347438	0.257738	0.142033	0.0826881	0.18514
GO:0046392	galactarate catabolic process	biological_process	Escherichia	Escherichia coli	0.266859	0	0	0	0	0.129873
GO:0046416	D-amino acid metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	13.8998	8.65483	7.6177	10.4077	13.1879	9.88361
GO:0046416	D-amino acid metabolic process	biological_process	Escherichia	Escherichia coli	0.0580624	0	0.107759	0	0	0
GO:0046417	chorismate metabolic process	biological_process	Escherichia	Escherichia coli	0.0721101	0	0	0	0	0
GO:0046417	chorismate metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.16534	0	0.306859	0	0.420168	0.432759
GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	4.0625	26.2796	22.4198	63.5567	64.0331	72.5068
GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.1685	18.7323	11.0275	18.782	17.4483	13.3658
GO:0046444	FMN metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0794256	0.457588	0.588683	1.70599	0.70834	0.422734
GO:0046459	short-chain fatty acid metabolic process	biological_process	Escherichia	Escherichia coli	0.0336125	0	0.211098	0	0	0.24694
GO:0046467	membrane lipid biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.266154	1.40968	0.781738	1.31692	1.02676	1.37405
GO:0046474	glycerophospholipid biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0046474	glycerophospholipid biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.162837	0	0.37763	0.291528	0.327171	0.378915
GO:0046487	glyoxylate metabolic process	biological_process	Escherichia	Escherichia coli	0.0661313	0	0	0	0	0
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	molecular_function	Clostridium	Clostridium thermocellum	1.90797	8.33124	5.07952	33.3417	25.5352	24.3338
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	22.4369	12.727	27.7473	8.96712	12.2831	20.0084
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.525672	1.42523	1.09036	0.253054	0.414178	0.369989
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	molecular_function	Clostridium	Clostridium thermocellum	13.9913	125.801	107.824	489.74	487.58	612.883
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	molecular_function	Escherichia	Escherichia coli	0.052278	0	0	0	0	0
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0908972	0.262726	0.0834919	0.673582	0.16236	0.150829
GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	55.8674	437.949	223.846	234.611	312.144	253.308
GO:0046553	D-malate dehydrogenase (decarboxylating) activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0963923	0	0	0
GO:0046555	acetylxylan esterase activity	molecular_function	Clostridium	Clostridium thermocellum	7.87794	11.7939	11.5945	20.9763	16.3192	17.9495
GO:0046556	alpha-L-arabinofuranosidase activity	molecular_function	Clostridium	Clostridium thermocellum	4.20574	10.9966	12.1554	20.5277	18.1504	28.5563
GO:0046618	drug export	biological_process	Escherichia	Escherichia coli	0.265619	0	0	0	0	0
GO:0046654	tetrahydrofolate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	4.67126	33.8886	28.8079	80.9409	73.8015	74.2593
GO:0046654	tetrahydrofolate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.397031	0	0.514032	0	0	0
GO:0046656	folic acid biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.92063	7.73797	5.93419	21.7524	18.4385	14.4682
GO:0046656	folic acid biosynthetic process	biological_process	Escherichia	Escherichia coli	0.331605	0	0.148851	0	0	0
GO:0046657	folic acid catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0557199
GO:0046677	response to antibiotic	biological_process	Clostridium	Clostridium thermocellum	133937	95941.1	83198.5	37694.8	49718	17106.2
GO:0046677	response to antibiotic	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.94741	5.0141	2.59939	7.62938	7.53182	5.54085
GO:0046677	response to antibiotic	biological_process	Escherichia	Escherichia coli	77929.1	0	34225.6	0	0	7845.75
GO:0046685	response to arsenic-containing substance	biological_process	Escherichia	Escherichia coli	0	0	0.0395583	0	0	0.185755
GO:0046685	response to arsenic-containing substance	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.295351	0.0951744	0.209879	0	0.449996
GO:0046686	response to cadmium ion	biological_process	Escherichia	Escherichia coli	0.0721344	0	0.0220119	0	0	0
GO:0046688	response to copper ion	biological_process	Escherichia	Escherichia coli	0.316682	0	0	0	0	0
GO:0046718	viral entry into host cell	biological_process	Escherichia	Escherichia coli	15.5896	0	16.7385	0	0	15.7476
GO:0046777	protein autophosphorylation	biological_process	Escherichia	Escherichia coli	0.542758	0	0.142265	0	0	0
GO:0046790	virion binding	molecular_function	Escherichia	Escherichia coli	0.0348277	0	0	0	0	0
GO:0046797	viral procapsid maturation	biological_process	Escherichia	Escherichia coli	15.7062	0	20.3094	0	0	17.5375
GO:0046820	4-amino-4-deoxychorismate synthase activity	molecular_function	Escherichia	Escherichia coli	0.0401017	0	0.148851	0	0	0
GO:0046834	lipid phosphorylation	biological_process	Escherichia	Escherichia coli	0	0	0.300724	0	0	0
GO:0046835	carbohydrate phosphorylation	biological_process	Escherichia	Escherichia coli	0.460051	0	1.23943	0	0	0.0247716
GO:0046839	phospholipid dephosphorylation	biological_process	Escherichia	Escherichia coli	0	0	0.244476	0	0	0.175277
GO:0046854	phosphatidylinositol phosphorylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	37.3761	42.5571	34.4422	32.5891	40.4493	39.8263
GO:0046854	phosphatidylinositol phosphorylation	biological_process	Escherichia	Escherichia coli	0	0	0.27587	0	0	0
GO:0046854	phosphatidylinositol phosphorylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.06735	0.260354	0.0717752	0.156587	0
GO:0046855	inositol phosphate dephosphorylation	biological_process	Escherichia	Escherichia coli	0	0	0.27587	0	0	0
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	molecular_function	Escherichia	Escherichia coli	0.234874	0	0.129049	0	0	0
GO:0046870	cadmium ion binding	molecular_function	Escherichia	Escherichia coli	0.0484137	0	0	0	0	0
GO:0046872	metal ion binding	molecular_function	Clostridium	Clostridium thermocellum	637.316	3232.35	2454.26	9667.48	8203.48	9482.64
GO:0046872	metal ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2580.65	2572.22	2601.62	1853.15	2273.33	1995.7
GO:0046872	metal ion binding	molecular_function	Escherichia	Escherichia coli	23.5591	0	27.1815	0	0	17.6502
GO:0046872	metal ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	29.4427	39.9169	36.3039	44.4933	25.18	38.1282
GO:0046873	metal ion transmembrane transporter activity	molecular_function	Clostridium	Clostridium thermocellum	10.2384	85.9525	69.6178	190.811	184.224	229.896
GO:0046873	metal ion transmembrane transporter activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.9464	21.2467	22.6546	14.1468	16.0176	13.2948
GO:0046873	metal ion transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.532599	0	0.289132	0	0	0
GO:0046873	metal ion transmembrane transporter activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.148189	0	0	0	0
GO:0046892	peptidyl-S-carbamoyl-L-cysteine dehydration	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0375455
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	molecular_function	Clostridium	Clostridium thermocellum	6.07001	49.1346	31.9077	100.8	94.2191	107.021
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0350707	0.06735	0.128598	0.427244	0.297894	0.5019
GO:0046914	transition metal ion binding	molecular_function	Clostridium	Clostridium thermocellum	8.52696	48.5364	33.3028	91.0216	90.0693	179.452
GO:0046914	transition metal ion binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.6478	11.8481	7.42383	5.30415	6.56615	7.80654
GO:0046914	transition metal ion binding	molecular_function	Escherichia	Escherichia coli	0.120767	0	0	0	0	0.0384186
GO:0046914	transition metal ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.80653	3.52302	2.83773	1.62066	1.52589	2.20179
GO:0046917	triphosphoribosyl-dephospho-CoA synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0632878	0	0.0587285	0.0645628	0.113029	0.0842105
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	Clostridium	Clostridium thermocellum	39.0864	407.387	328.627	946.847	865.463	694.314
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	183.204	126.744	100.241	127.327	168.807	136.313
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	Escherichia	Escherichia coli	0.280274	0	0.376683	0	0	0
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.76062	0.488906	1.63768	1.46582	1.1552	1.68208
GO:0046944	protein carbamoylation	biological_process	Clostridium	Clostridium thermocellum	0.241607	3.27014	1.08914	9.48984	7.39755	8.80261
GO:0046944	protein carbamoylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.79985	8.39756	4.91912	6.8849	7.22312	7.9444
GO:0046944	protein carbamoylation	biological_process	Escherichia	Escherichia coli	0	0	0.0214706	0	0	0
GO:0046944	protein carbamoylation	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0714782	0.343191	0.442223	0.231615	0.0850971	0.110825
GO:0046952	ketone body catabolic process	biological_process	Escherichia	Escherichia coli	0.0336125	0	0.0312136	0	0	0.24694
GO:0046961	proton-transporting ATPase activity, rotational mechanism	molecular_function	Clostridium	Clostridium thermocellum	15.4849	150.642	114.174	394.142	360.224	266.265
GO:0046961	proton-transporting ATPase activity, rotational mechanism	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	51.5972	34.4361	30.137	39.0334	51.421	33.217
GO:0046961	proton-transporting ATPase activity, rotational mechanism	molecular_function	Escherichia	Escherichia coli	0.0680757	0	0.252415	0	0	0
GO:0046961	proton-transporting ATPase activity, rotational mechanism	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0633607	0.162611	0.622377	0.595192	0.44823	0.779594
GO:0046982	protein heterodimerization activity	molecular_function	Escherichia	Escherichia coli	0.0735441	0	0.0675693	0	0	0.0557199
GO:0046982	protein heterodimerization activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.996102	1.02038	0.8632	0.713151	0.591752	1.67855
GO:0046983	protein dimerization activity	molecular_function	Clostridium	Clostridium thermocellum	4.03843	22.7861	16.3044	71.33	61.2833	62.8522
GO:0046983	protein dimerization activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.242554	0.556256	0.889407	0.37529	0.286609	0.599692
GO:0047001	2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	1.43953	0	0	0	0	0
GO:0047017	prostaglandin-F synthase activity	molecular_function	Escherichia	Escherichia coli	0.143394	0	0	0	0	0
GO:0047068	N5,N10-methenyltetrahydromethanopterin hydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.932547	1.73215	2.1757	2.31429	2.1895	5.72751
GO:0047111	formate dehydrogenase (cytochrome-c-553) activity	molecular_function	Escherichia	Escherichia coli	0.0717456	0	0	0	0	0.0111569
GO:0047134	protein-disulfide reductase activity	molecular_function	Escherichia	Escherichia coli	0.0314008	0	0	0	0	0
GO:0047138	aquacobalamin reductase activity	molecular_function	Escherichia	Escherichia coli	0.086012	0	0.23753	0	0	0
GO:0047151	methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity	molecular_function	Clostridium	Clostridium thermocellum	1.54783	8.23481	3.57378	33.2139	32.0653	25.7839
GO:0047151	methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	15.3952	25.0556	21.3114	16.3395	17.3561	16.2648
GO:0047154	methylmalonyl-CoA carboxytransferase activity	molecular_function	Clostridium	Clostridium thermocellum	9.46407	45.2124	18.9764	191.309	126.004	123.774
GO:0047241	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0822449	0	0	0	0	0
GO:0047244	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.405076	2.40616	2.02437	5.00743	5.81415	7.05007
GO:0047270	lipopolysaccharide glucosyltransferase II activity	molecular_function	Escherichia	Escherichia coli	0.279254	0	0.0518272	0	0	0.148694
GO:0047294	phosphoglycerol geranylgeranyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.162837	0	0.37763	0.291528	0.327171	0.378915
GO:0047295	geranylgeranylglycerol-phosphate geranylgeranyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.10719	0.187014	0.092942
GO:0047298	(S)-3-amino-2-methylpropionate transaminase activity	molecular_function	Escherichia	Escherichia coli	0.0217764	0	0.079748	0	0	0
GO:0047310	glutamine-scyllo-inositol transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	0.21441	2.05887	0.309565	6.04406	8.5926	8.3998
GO:0047324	phosphoenolpyruvate-glycerone phosphotransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0350877
GO:0047334	diphosphate-fructose-6-phosphate 1-phosphotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	7.50242	63.6197	37.5005	278.781	233.258	164.662
GO:0047355	CDP-glycerol glycerophosphotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0454972	0	0	0.0465569	0.0406062	0
GO:0047355	CDP-glycerol glycerophosphotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.8887	25.5153	10.5777	19.2544	22.5056	21.648
GO:0047360	undecaprenyl-phosphate galactose phosphotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.31325	18.5234	21.8266	35.8816	36.2974	57.8469
GO:0047372	acylglycerol lipase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	130.308	180.976	306.722	127.162	177.056	100.76
GO:0047429	nucleoside-triphosphate diphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	4.42378	27.4467	20.7349	59.5457	61.5965	71.5612
GO:0047429	nucleoside-triphosphate diphosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.9694	79.6803	76.3232	58.9659	71.4159	58.7156
GO:0047429	nucleoside-triphosphate diphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.235117	0.564237	1.08797	0.960733	0.471539	1.87452
GO:0047440	2-dehydro-3-deoxy-D-pentonate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.0899007	0	0	0	0	0
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	2.00445	17.7779	12.3916	52.541	46.1825	72.3142
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.294815	0	0	0
GO:0047475	phenylacetate-CoA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	7.14724	53.8933	41.7253	103.042	95.011	84.8779
GO:0047475	phenylacetate-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.0514031	0	0	0	0	0
GO:0047475	phenylacetate-CoA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.294541	0.161957	0.702937	0.517149	0.187709	0.47619
GO:0047480	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.66061	18.9106	21.8839	51.6569	46.4233	52.6138
GO:0047480	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	93.6144	85.4518	89.3883	66.6686	70.5838	51.1285
GO:0047480	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	molecular_function	Escherichia	Escherichia coli	0.0401989	0	0	0	0	0
GO:0047480	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0623642	0.159577	0.0385659	0.127484	0.111271	0.0552672
GO:0047484	regulation of response to osmotic stress	biological_process	Escherichia	Escherichia coli	0.0815887	0	0	0	0	0
GO:0047527	2,3-dihydroxybenzoate-serine ligase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.127425	0	0	0
GO:0047553	2-oxoglutarate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	10.2128	109.242	75.1143	275.178	259.948	203.582
GO:0047553	2-oxoglutarate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	61.2888	50.6646	77.3708	26.7822	35.8421	40.8824
GO:0047553	2-oxoglutarate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0984557	0.225854	0.251197	0.632696	0.527142	0.219355
GO:0047617	acyl-CoA hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.0976051	0	0	0	0	0
GO:0047631	ADP-ribose diphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	3.0439600000000002	23.2511	19.2002	64.0822	62.3987	82.9162
GO:0047631	ADP-ribose diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.101275	0	0	0	0	0
GO:0047693	ATP diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0150928	0	0	0	0	0
GO:0047760	butyrate-CoA ligase activity	molecular_function	Clostridium	Clostridium thermocellum	2.00474	6.15989	3.39344	23.8122	21.0374	16.1112
GO:0047760	butyrate-CoA ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.215553	0.207418	0	0	0	0
GO:0047761	butyrate kinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	99.7304	47.3327	54.2261	18.4366	26.1416	51.9546
GO:0047850	diaminopimelate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	2.37006	16.0535	10.7892	47.5035	45.7581	47.6459
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	molecular_function	Clostridium	Clostridium thermocellum	1.81461	8.36484	5.49274	33.4607	32.5297	24.5134
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.221021	0.396106	0	0
GO:0048001	erythrose-4-phosphate dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.055875	0	0	0	0	0
GO:0048029	monosaccharide binding	molecular_function	Clostridium	Clostridium thermocellum	8.9723	20.5811	17.6418	48.8933	48.7887	64.0767
GO:0048029	monosaccharide binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.691985	1.13095	2.00534	0.404388	0.791896	0.524763
GO:0048029	monosaccharide binding	molecular_function	Escherichia	Escherichia coli	0.265789	0	0	0	0	0
GO:0048034	heme O biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0657425	0	0.122238	0	0	0
GO:0048037	cofactor binding	molecular_function	Clostridium	Clostridium thermocellum	23.4304	122.456	112.408	309.517	238.34	368.942
GO:0048037	cofactor binding	molecular_function	Escherichia	Escherichia coli	0.14772	0	0	0	0	0.114674
GO:0048037	cofactor binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.132895	0	0	0.0679452	0.118585	0
GO:0048038	quinone binding	molecular_function	Clostridium	Clostridium thermocellum	0.783927	6.16806	3.72998	19.1628	18.519	16.1259
GO:0048038	quinone binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	114.64	130.538	140.443	157.122	149.942	80.4752
GO:0048038	quinone binding	molecular_function	Escherichia	Escherichia coli	0.460367	0	0.579391	0	0	0.228183
GO:0048038	quinone binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.123683	0	0.181147	0.940688	0.628191	0.251338
GO:0048040	UDP-glucuronate decarboxylase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.0923797	0	0	0.0630458	0.0274976	0.0819791
GO:0048388	endosomal lumen acidification	biological_process	Clostridium	Clostridium thermocellum	0.844128	1.36483	0.989498	14.7573	12.6659	10.6787
GO:0048388	endosomal lumen acidification	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0151414	0.116311	0.168608	0.123953	0.0946464	0.362616
GO:0048472	threonine-phosphate decarboxylase activity	molecular_function	Clostridium	Clostridium thermocellum	1.31388	10.2492	9.35046	27.9337	25.8596	34.5376
GO:0048472	threonine-phosphate decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.228701	0.0627293	0.181869	0.0668509	0.0583808	0.434602
GO:0048473	D-methionine transport	biological_process	Escherichia	Escherichia coli	0.291284	0	0.135454	0	0	0
GO:0048511	rhythmic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.62028	2.65867	0	0	0.824819	0
GO:0048870	cell motility	biological_process	Escherichia	Escherichia coli	0	0	0.142987	0	0	0
GO:0050081	maltose-6'-phosphate glucosidase activity	molecular_function	Escherichia	Escherichia coli	0.0207314	0	0.115382	0	0	0
GO:0050089	mannose isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0826348	0	0	0
GO:0050136	NADH dehydrogenase (quinone) activity	molecular_function	Clostridium	Clostridium thermocellum	0.331191	4.92771	2.86822	9.38924	10.3754	12.6874
GO:0050163	oxaloacetate tautomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.06784	0	0	0.042752
GO:0050182	phosphate butyryltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	84.1331	96.2858	106.577	80.2442	97.0631	110.934
GO:0050225	pseudouridine kinase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.112378
GO:0050242	pyruvate, phosphate dikinase activity	molecular_function	Clostridium	Clostridium thermocellum	2.59281	11.6392	13.25	49.2864	44.0848	41.199
GO:0050242	pyruvate, phosphate dikinase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	53.4174	54.7495	42.6241	62.2203	69.7192	37.1381
GO:0050263	ribosylpyrimidine nucleosidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0567438	0	0	0.040844
GO:0050270	S-adenosylhomocysteine deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.16138	9.32091	3.97432	40.4601	33.0883	28.9094
GO:0050270	S-adenosylhomocysteine deaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0428724	0	0.0795225	0	0	0.0570135
GO:0050297	stizolobate synthase activity	molecular_function	Escherichia	Escherichia coli	0.109417	0	0	0	0	0
GO:0050308	sugar-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0.549369	0	0.318541	0	0	0.235589
GO:0050355	triphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	0.295999	3.34197	2.52293	10.5247	8.16498	9.25041
GO:0050355	triphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0421918	0	0	0	0	0
GO:0050380	undecaprenyl-diphosphatase activity	molecular_function	Clostridium	Clostridium thermocellum	1.23491	9.13104	5.3175	27.0817	19.7135	23.0007
GO:0050380	undecaprenyl-diphosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	9.94741	5.0141	2.59939	7.62938	7.53182	5.54085
GO:0050380	undecaprenyl-diphosphatase activity	molecular_function	Escherichia	Escherichia coli	0.0700686	0	0	0	0	0
GO:0050380	undecaprenyl-diphosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.281003	0.744397	0.263782	0.502426	0.109621	0
GO:0050418	hydroxylamine reductase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0657425	0	0	0.672563	0.58702	0.524666
GO:0050418	hydroxylamine reductase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0600366	0	0	0
GO:0050418	hydroxylamine reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.642915	1.0699	0.954586	0.394565	0.344447	0.142582
GO:0050454	coenzyme F420 hydrogenase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	14.4802	5.58436	16.7493	14.0663	9.30224	8.95946
GO:0050462	N-acetylneuraminate synthase activity	molecular_function	Clostridium	Clostridium thermocellum	2.01823	7.02629	4.44239	48.2055	36.2254	39.8759
GO:0050480	imidazolonepropionase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.62478	1.16768	3.34324	0.222239	0.523626	0.722321
GO:0050485	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	42.2174	67.3724	100.564	54.2061	62.3147	39.6642
GO:0050492	glycerol-1-phosphate dehydrogenase [NAD(P)+] activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	26.9496	29.1195	18.9011	34.006100000000004	35.9212	26.0876
GO:0050492	glycerol-1-phosphate dehydrogenase [NAD(P)+] activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.652467	0.832564	0.908126	0.445101	0.145627	0.433826
GO:0050511	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.54379	8.55392	5.82296	31.9707	23.7419	22.9967
GO:0050511	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0536877	0	0	0	0	0
GO:0050515	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity	molecular_function	Clostridium	Clostridium thermocellum	0.848941	11.2061	6.29861	25.2185	22.7673	27.9916
GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.344656	4.62774	3.83869	11.3675	8.69026	9.27282
GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	21.76	21.9113	19.3042	21.3913	29.527	21.6888
GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.173288	0	0	0	0	0
GO:0050524	coenzyme-B sulfoethylthiotransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	13.3118	5.09979	12.4445	8.37245	5.00675	6.70278
GO:0050532	2-phosphosulfolactate phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	53.5065	48.6657	49.1516	34.1438	35.34	36.2278
GO:0050532	2-phosphosulfolactate phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.183082	0.614785	0.339786	0.655626	0.572045	0.426324
GO:0050545	sulfopyruvate decarboxylase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.497091	0.362934	0.552778	0.060509	0.212775	0
GO:0050560	aspartate-tRNA(Asn) ligase activity	molecular_function	Clostridium	Clostridium thermocellum	3.08479	10.53	7.33533	31.6193	26.3966	21.6467
GO:0050560	aspartate-tRNA(Asn) ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0417544	0.0801853	0.154985	0.213386	0.0372856	0.138863
GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	Clostridium	Clostridium thermocellum	3.12545	15.906	14.9013	46.4618	52.7237	54.1587
GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.7495	26.3112	22.9783	19.8318	22.7685	18.6935
GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.846073	0.616558	0.66604	0.462137	0.606228	0.603799
GO:0050568	protein-glutamine glutaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.16916	4.866	4.02655	38.4534	35.0295	26.73
GO:0050568	protein-glutamine glutaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.14981	0	0	0	0	0
GO:0050569	glycolaldehyde dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.0389594	0	0	0	0	0
GO:0050570	4-hydroxythreonine-4-phosphate dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	0.806992	4.3834	5.1142	9.48325	7.42947	10.5914
GO:0050570	4-hydroxythreonine-4-phosphate dehydrogenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	4.07375	7.12706	5.74208	2.3601	3.26514	4.11351
GO:0050572	L-idonate 5-dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.110219	0	0	0	0	0.0733446
GO:0050583	hydrogen dehydrogenase (NADP+) activity	molecular_function	Clostridium	Clostridium thermocellum	0.799117	5.95667	2.0352	64.6092	63.8474	70.9831
GO:0050605	superoxide reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	100.946	67.9705	80.2931	72.2024	85.5126	89.8118
GO:0050605	superoxide reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.432564	2.69489	1.20285	0.665201	0.848041	0.717374
GO:0050660	flavin adenine dinucleotide binding	molecular_function	Clostridium	Clostridium thermocellum	39.1212	295.226	284.114	849.572	733.461	667.203
GO:0050660	flavin adenine dinucleotide binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	131.205	138.242	96.7743	100.84	119.205	97.7285
GO:0050660	flavin adenine dinucleotide binding	molecular_function	Escherichia	Escherichia coli	1.62823	0	1.70994	0	0	0.642768
GO:0050660	flavin adenine dinucleotide binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	15.6636	8.30235	19.3987	15.7627	10.4154	10.2382
GO:0050661	NADP binding	molecular_function	Clostridium	Clostridium thermocellum	41.3139	386.441	261.994	1141.59	1195.07	1007.27
GO:0050661	NADP binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	72.6739	273.121	209.922	182.837	266.242	187.484
GO:0050661	NADP binding	molecular_function	Escherichia	Escherichia coli	0.938355	0	0.495403	0	0	0.0260975
GO:0050661	NADP binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.35737	5.8061	5.53067	3.35175	1.88064	4.10507
GO:0050662	coenzyme binding	molecular_function	Clostridium	Clostridium thermocellum	2.82547	21.2995	13.4876	47.656	36.4372	51.4067
GO:0050662	coenzyme binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	92.0826	136.758	127.533	110.318	134.967	120.803
GO:0050662	coenzyme binding	molecular_function	Escherichia	Escherichia coli	0.143613	0	0.274968	0	0	0.0489934
GO:0050662	coenzyme binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.117777	0.494647	0.323593	0.566069	0.380669	0.389457
GO:0050782	galactose uniporter activity	molecular_function	Escherichia	Escherichia coli	0.172097	0	0.109022	0	0	0
GO:0050797	thymidylate synthase (FAD) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	32.4181	24.5272	22.7811	26.6489	29.5605	19.1002
GO:0050821	protein stabilization	biological_process	Escherichia	Escherichia coli	1.17768	0	0	0	0	0
GO:0050897	cobalt ion binding	molecular_function	Escherichia	Escherichia coli	0.141523	0	0.180065	0	0	0.288431
GO:0050897	cobalt ion binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.06098	1.41622	6.55711	7.25927	8.9755	7.6095
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	biological_process	Escherichia	Escherichia coli	0.361523	0	0.379841	0	0	0.0899345
GO:0050919	negative chemotaxis	biological_process	Escherichia	Escherichia coli	0.0341229	0	0	0	0	0
GO:0050983	deoxyhypusine biosynthetic process from spermidine	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.125603	0	0	0.28919	0	0.0417172
GO:0050992	dimethylallyl diphosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	10.7237	46.6363	29.7841	186.272	153.421	117.459
GO:0050992	dimethylallyl diphosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.63248	1.26724	0.451695	2.02813	2.76315	2.82221
GO:0050992	dimethylallyl diphosphate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.121836	0	0	0	0	0
GO:0051060	pullulanase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	71.8698	13.8513	20.8748	10.7321	12.5328	16.2434
GO:0051073	adenosylcobinamide-GDP ribazoletransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.529245	6.25324	3.85109	14.4517	14.1	18.0306
GO:0051073	adenosylcobinamide-GDP ribazoletransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.151602	0	0	0
GO:0051073	adenosylcobinamide-GDP ribazoletransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0.225532	0.165809	0.0723358	0.215506
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	biological_process	Escherichia	Escherichia coli	0.201602	0	0.187552	0	0	0
GO:0051103	DNA ligation involved in DNA repair	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110778	0.060769	0.117502	0.145714	0.0847716	0.126316
GO:0051108	carnitine-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.069704	0	0.0642766	0	0	0
GO:0051109	crotonobetaine-CoA ligase activity	molecular_function	Escherichia	Escherichia coli	0.069704	0	0.0642766	0	0	0
GO:0051116	cobaltochelatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0293107	0.0187628	0.145017	0.0799574	0.0784994	0.12997
GO:0051156	glucose 6-phosphate metabolic process	biological_process	Escherichia	Escherichia coli	0	0	0.404198	0	0	0
GO:0051186	cofactor metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	3.1352	1.82909	1.6582	6.13782	3.74195	5.20659
GO:0051188	cofactor biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	1.61352	22.1508	20.8666	38.4793	38.9153	60.6715
GO:0051188	cofactor biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	1.46276	2.28943	2.91662	0.637297	0.99204	1.80244
GO:0051205	protein insertion into membrane	biological_process	Clostridium	Clostridium thermocellum	4.2142	27.8186	18.5678	87.6912	80.7945	71.4186
GO:0051205	protein insertion into membrane	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	11.9072	4.96719	2.44729	10.8778	13.9986	7.32919
GO:0051205	protein insertion into membrane	biological_process	Escherichia	Escherichia coli	0.300082	0	0	0	0	0
GO:0051213	dioxygenase activity	molecular_function	Clostridium	Clostridium thermocellum	0.372484	1.76534	1.72627	21.9498	17.421	12.2609
GO:0051213	dioxygenase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	89.9172	7.84009	9.02813	38.6527	46.3505	23.1125
GO:0051252	regulation of RNA metabolic process	biological_process	Escherichia	Escherichia coli	0.0135617	0	0	0	0	0.0352171
GO:0051258	protein polymerization	biological_process	Clostridium	Clostridium thermocellum	12.0632	81.9794	60.0784	204.496	182.774	233.796
GO:0051258	protein polymerization	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	43.0316	45.2198	45.1907	42.857	46.1551	35.4182
GO:0051258	protein polymerization	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	7.95292	10.0726	7.46988	3.24533	2.46094	4.63953
GO:0051259	protein oligomerization	biological_process	Clostridium	Clostridium thermocellum	1.82297	13.1449	13.7533	31.2698	33.892	34.5316
GO:0051259	protein oligomerization	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	58.4295	48.081	48.318600000000004	16.422	24.8708	34.0323
GO:0051259	protein oligomerization	biological_process	Escherichia	Escherichia coli	0.151439	0	0	0	0	0
GO:0051260	protein homooligomerization	biological_process	Escherichia	Escherichia coli	0.0977023	0	0.0675693	0	0	0
GO:0051262	protein tetramerization	biological_process	Escherichia	Escherichia coli	0	0	0.284125	0	0	0
GO:0051271	negative regulation of cellular component movement	biological_process	Escherichia	Escherichia coli	0.103414	0	0	0	0	0
GO:0051276	chromosome organization	biological_process	Escherichia	Escherichia coli	0.0836546	0	0	0	0	0
GO:0051287	NAD binding	molecular_function	Clostridium	Clostridium thermocellum	70.0845	685.082	524.908	2108.29	1994.74	1701.91
GO:0051287	NAD binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	237.47	362.961	314.02	286.644	366.902	246.262
GO:0051287	NAD binding	molecular_function	Escherichia	Escherichia coli	2.65395	0	0.577046	0	0	0.0636106
GO:0051287	NAD binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.7356	2.90945	3.58429	3.38559	1.68597	4.20761
GO:0051289	protein homotetramerization	biological_process	Clostridium	Clostridium thermocellum	1.23664	9.73149	5.3981	27.9807	25.9851	38.4535
GO:0051289	protein homotetramerization	biological_process	Escherichia	Escherichia coli	0.508951	0	0.531623	0	0	0.282998
GO:0051301	cell division	biological_process	Clostridium	Clostridium thermocellum	93.0019	642.626	533.72	1554.86	1439.93	1619.37
GO:0051301	cell division	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	377.684	382.711	328.354	314.927	346.973	273.02
GO:0051301	cell division	biological_process	Escherichia	Escherichia coli	1.81651	0	0.65968	0	0	0.727916
GO:0051301	cell division	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110778	0.060769	0.117502	0.145714	0.0847716	0.126316
GO:0051302	regulation of cell division	biological_process	Clostridium	Clostridium thermocellum	2.1843	6.72123	11.0618	36.7201	30.3302	29.292
GO:0051304	chromosome separation	biological_process	Clostridium	Clostridium thermocellum	0.598098	2.71552	4.03521	9.00478	12.1324	10.1976
GO:0051345	positive regulation of hydrolase activity	biological_process	Escherichia	Escherichia coli	0.10949	0	0	0	0	0
GO:0051391	tRNA acetylation	biological_process	Escherichia	Escherichia coli	0	0	0.096708	0	0	0
GO:0051392	tRNA N-acetyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.096708	0	0	0
GO:0051409	response to nitrosative stress	biological_process	Escherichia	Escherichia coli	0.0466881	0	0	0	0	0
GO:0051454	intracellular pH elevation	biological_process	Escherichia	Escherichia coli	0.0229187	0	0	0	0	0
GO:0051536	iron-sulfur cluster binding	molecular_function	Clostridium	Clostridium thermocellum	29.0619	366.197	283.429	750.452	678.288	667.201
GO:0051536	iron-sulfur cluster binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	846.461	519.291	520.828	308.785	377.676	285.903
GO:0051536	iron-sulfur cluster binding	molecular_function	Escherichia	Escherichia coli	0.249554	0	0.110375	0	0	0.0593419
GO:0051536	iron-sulfur cluster binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	16.4062	13.9493	19.097	16.9624	11.5156	14.0864
GO:0051537	2 iron, 2 sulfur cluster binding	molecular_function	Clostridium	Clostridium thermocellum	8.40638	157.22	119.713	352.273	335.739	391.002
GO:0051537	2 iron, 2 sulfur cluster binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	19.8887	51.5596	28.3769	26.604	56.1896	72.3144
GO:0051537	2 iron, 2 sulfur cluster binding	molecular_function	Escherichia	Escherichia coli	0.790076	0	1.50975	0	0	0.0369957
GO:0051537	2 iron, 2 sulfur cluster binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	1.03183	3.62458	3.52966	6.10746	2.67274	5.49318
GO:0051538	3 iron, 4 sulfur cluster binding	molecular_function	Clostridium	Clostridium thermocellum	10.7237	46.6363	29.7841	186.272	153.421	117.459
GO:0051538	3 iron, 4 sulfur cluster binding	molecular_function	Escherichia	Escherichia coli	0.205151	0	0.0465498	0	0	0
GO:0051539	4 iron, 4 sulfur cluster binding	molecular_function	Clostridium	Clostridium thermocellum	288.147	1830.98	1478.41	4777.71	4082.78	4764.19
GO:0051539	4 iron, 4 sulfur cluster binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	603.401	378.442	469.489	275.824	362.126	318.589
GO:0051539	4 iron, 4 sulfur cluster binding	molecular_function	Escherichia	Escherichia coli	3.06032	0	1.89352	0	0	0.607421
GO:0051539	4 iron, 4 sulfur cluster binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	10.8238	20.2126	20.4974	26.843	14.6219	21.6572
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0705914	0	0	0
GO:0051595	response to methylglyoxal	biological_process	Escherichia	Escherichia coli	0.298308	0	0.266082	0	0	0.0856334
GO:0051603	proteolysis involved in cellular protein catabolic process	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0846632
GO:0051604	protein maturation	biological_process	Escherichia	Escherichia coli	0.111629	0	0.117006	0	0	0.0375455
GO:0051606	detection of stimulus	biological_process	Clostridium	Clostridium thermocellum	4.93358	18.9337	16.2534	63.1571	73.0955	145.364
GO:0051607	defense response to virus	biological_process	Clostridium	Clostridium thermocellum	8.10355	3.93972	1.40096	17.8139	13.038	20.0466
GO:0051607	defense response to virus	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5.5248	2.45653	1.18021	1.52713	3.02595	2.5506
GO:0051607	defense response to virus	biological_process	Escherichia	Escherichia coli	0.699349	0	0.795856	0	0	0.0697873
GO:0051607	defense response to virus	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.814623	0.797092	1.12509	0.367456	1.15134	0.865938
GO:0051692	cellular oligosaccharide catabolic process	biological_process	Escherichia	Escherichia coli	0.104191	0	0.0487149	0	0	0
GO:0051726	regulation of cell cycle	biological_process	Clostridium	Clostridium thermocellum	2.1843	6.72123	11.0618	36.7201	30.3302	29.292
GO:0051745	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity	molecular_function	Clostridium	Clostridium thermocellum	10.7237	46.6363	29.7841	186.272	153.421	117.459
GO:0051745	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.63248	1.26724	0.451695	2.02813	2.76315	2.82221
GO:0051775	response to redox state	biological_process	Clostridium	Clostridium thermocellum	2.40763	14.705	10.6371	34.7976	28.0143	40.7787
GO:0051775	response to redox state	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.0234	42.4295	43.0026	32.0197	37.1684	34.5454
GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0939565	0	0	0.0336971
GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity	molecular_function	Escherichia	Escherichia coli	0.0198321	0	0	0	0	0
GO:0051912	CoB--CoM heterodisulfide reductase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	4.45484	3.66033	3.96183	9.47997	5.81855	8.38619
GO:0051920	peroxiredoxin activity	molecular_function	Clostridium	Clostridium thermocellum	16.6655	197.62	147.526	503.683	345.685	656.368
GO:0051920	peroxiredoxin activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	245.438	538.765	456.814	334.051	461.701	429.056
GO:0051920	peroxiredoxin activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.657255	2.56686	1.64981	0.267901	0.466917	0.631417
GO:0051978	lysophospholipid transporter activity	molecular_function	Escherichia	Escherichia coli	0.0231618	0	0.0432119	0	0	0.0610558
GO:0051989	coproporphyrinogen dehydrogenase activity	molecular_function	Clostridium	Clostridium thermocellum	0.562736	5.12201	2.95248	9.71208	10.8358	8.56095
GO:0051989	coproporphyrinogen dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0368519	0	0	0
GO:0051991	UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.54379	8.55392	5.82296	31.9707	23.7419	22.9967
GO:0051991	UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity	molecular_function	Escherichia	Escherichia coli	0.0536877	0	0	0	0	0
GO:0051992	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.48304	21.2983	23.8072	68.5512	55.4425	61.7905
GO:0051992	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	102.047	48.8863	42.9468	45.5351	37.9895	28.5499
GO:0051992	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0536634	0	0	0.0549132	0	0.142776
GO:0052131	positive aerotaxis	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0235751
GO:0052381	tRNA dimethylallyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.42358	5.89156	6.37795	27.6865	30.4344	39.958
GO:0052381	tRNA dimethylallyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	3.11746	2.41849	1.54029	1.40437	1.32917	1.29456
GO:0052381	tRNA dimethylallyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0606386	0	0	0	0	0
GO:0052547	regulation of peptidase activity	biological_process	Clostridium	Clostridium thermocellum	1.07971	2.46217	0.685887	10.4612	7.32033	7.00399
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	Escherichia	Escherichia coli	0.0716727	0	0.0664868	0	0	0
GO:0052618	coenzyme F420-0:L-glutamate ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159629	0.229914	0.147994	0.366486	0.14248	0.265502
GO:0052619	coenzyme F420-1:gamma-L-glutamate ligase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.159629	0.229914	0.147994	0.366486	0.14248	0.265502
GO:0052621	diguanylate cyclase activity	molecular_function	Escherichia	Escherichia coli	0.131169	0	0.0671634	0	0	0.122855
GO:0052645	F420-0 metabolic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.420703	0.818608	0.96072	0.724417	0.181523	0.440326
GO:0052653	3',5'-cyclic diguanylic acid metabolic process	biological_process	Escherichia	Escherichia coli	0.0269046	0	0.049932699999999997	0	0	0
GO:0052654	L-leucine transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.90122	27.9123	17.6762	74.296	70.4999	72.3582
GO:0052654	L-leucine transaminase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.115427	0	0	0.0414585
GO:0052654	L-leucine transaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.442746	0.534826	0.58977	0.205071	0.306767
GO:0052655	L-valine transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.90122	27.9123	17.6762	74.296	70.4999	72.3582
GO:0052655	L-valine transaminase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.115427	0	0	0.0414585
GO:0052655	L-valine transaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.442746	0.534826	0.58977	0.205071	0.306767
GO:0052656	L-isoleucine transaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.90122	27.9123	17.6762	74.296	70.4999	72.3582
GO:0052656	L-isoleucine transaminase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.115427	0	0	0.0414585
GO:0052656	L-isoleucine transaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.442746	0.534826	0.58977	0.205071	0.306767
GO:0052657	guanine phosphoribosyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	8.76042	9.12357	11.0711	12.0851	15.1185	13.2017
GO:0052657	guanine phosphoribosyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.125603	0	0.23311	0	0	0.309904
GO:0052657	guanine phosphoribosyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.634761	0.307761	0.0564054	0.0984227	0
GO:0052665	tRNA (uracil-2'-O-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0862065	0	0	0	0	0
GO:0052666	tRNA (cytosine-2'-O-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0862065	0	0	0	0	0
GO:0052689	carboxylic ester hydrolase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0806165	0.619079	0.298965	0.988637	0.827684	0.858533
GO:0052689	carboxylic ester hydrolase activity	molecular_function	Escherichia	Escherichia coli	0.52261	0	0.222735	0	0	0.0798124
GO:0052692	raffinose alpha-galactosidase activity	molecular_function	Escherichia	Escherichia coli	0.0402961	0	0	0	0	0
GO:0052693	epoxyqueuosine reductase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.182185	0	0	0
GO:0052717	tRNA-specific adenosine-34 deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	4.98695	33.4582	24.2697	95.8039	74.3148	108.515
GO:0052717	tRNA-specific adenosine-34 deaminase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.08128	3.25926	2.86254	0.867992	1.23995	2.77157
GO:0052717	tRNA-specific adenosine-34 deaminase activity	molecular_function	Escherichia	Escherichia coli	0.068659	0	0	0	0	0
GO:0052733	quinate 3-dehydrogenase (NADP+) activity	molecular_function	Escherichia	Escherichia coli	0.0327619	0	0	0	0	0
GO:0052734	shikimate 3-dehydrogenase (NAD+) activity	molecular_function	Escherichia	Escherichia coli	0.0327619	0	0	0	0	0
GO:0052737	pyruvate dehydrogenase (quinone) activity	molecular_function	Escherichia	Escherichia coli	0.046445	0	0	0	0	0
GO:0052832	inositol monophosphate 3-phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	37.3761	42.5571	34.4422	32.5891	40.4493	39.8263
GO:0052832	inositol monophosphate 3-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.27587	0	0	0
GO:0052832	inositol monophosphate 3-phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.06735	0.260354	0.0717752	0.156587	0
GO:0052833	inositol monophosphate 4-phosphatase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	37.3761	42.5571	34.4422	32.5891	40.4493	39.8263
GO:0052833	inositol monophosphate 4-phosphatase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.27587	0	0	0
GO:0052833	inositol monophosphate 4-phosphatase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0701415	0.06735	0.260354	0.0717752	0.156587	0
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	molecular_function	Clostridium	Clostridium thermocellum	2.71029	21.5149	19.8022	58.2358	63.1596	61.3673
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	41.9319	35.3397	35.2756	29.3285	37.2414	29.4029
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	molecular_function	Escherichia	Escherichia coli	0.0351437	0	0	0	0	0
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0861822	0.0661832	0.191928	0.0705068	0.0615712	0.16053
GO:0052856	NADHX epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0351437	0	0	0	0	0
GO:0052857	NADPHX epimerase activity	molecular_function	Escherichia	Escherichia coli	0.0351437	0	0	0	0	0
GO:0052865	1-deoxy-D-xylulose 5-phosphate biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.50876	20.0741	11.6512	48.092	46.587	44.3945
GO:0052865	1-deoxy-D-xylulose 5-phosphate biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	58.509	41.4332	32.2915	34.7667	42.3967	30.6407
GO:0052875	riboflavin reductase (NADH) activity	molecular_function	Escherichia	Escherichia coli	0.086012	0	0.23753	0	0	0
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	molecular_function	Escherichia	Escherichia coli	0.065864	0	0.0611642	0	0	0
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.67734	8.31579	3.26426	21.8374	22.1119	21.0588
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.937	22.5368	17.8595	24.4585	29.2359	18.1588
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0830956	0	0.43699	0	0	0
GO:0052908	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.480005	3.09628	2.75081	11.3416	10.0213	10.6301
GO:0052908	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	11.0203	9.38784	6.66771	7.82058	9.52142	8.62006
GO:0052911	23S rRNA (guanine(745)-N(1))-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.151123	0	0	0	0	0
GO:0052913	16S rRNA (guanine(966)-N(2))-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.826678	3.28045	1.94336	12.8537	9.63987	16.2693
GO:0052914	16S rRNA (guanine(1207)-N(2))-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0551216	0	0	0	0	0
GO:0052915	23S rRNA (guanine(2445)-N(2))-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0247901	0	0	0	0	0
GO:0052916	23S rRNA (guanine(1835)-N(2))-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.04924	0	0.0913855	0	0	0
GO:0052927	CTP:tRNA cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0223111	0	0	0	0	0
GO:0052927	CTP:tRNA cytidylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0052928	CTP:3'-cytidine-tRNA cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0223111	0	0	0	0	0
GO:0052928	CTP:3'-cytidine-tRNA cytidylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0223111	0	0	0	0	0
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.15365	0.0742451	0.0614043	0.0178615	0
GO:0055062	phosphate ion homeostasis	biological_process	Escherichia	Escherichia coli	0.0724747	0	0	0	0	0
GO:0055070	copper ion homeostasis	biological_process	Escherichia	Escherichia coli	0.0418759	0	0	0	0	0
GO:0055072	iron ion homeostasis	biological_process	Clostridium	Clostridium thermocellum	0	0	0	0.0248701	0.0976414	0.048476
GO:0055072	iron ion homeostasis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	6.08462	5.46879	4.18758	3.62868	3.38264	2.09136
GO:0055072	iron ion homeostasis	biological_process	Escherichia	Escherichia coli	0.488852	0	0.713447	0	0	0.115806
GO:0055085	transmembrane transport	biological_process	Clostridium	Clostridium thermocellum	10.823	32.2052	22.3919	176.205	153.093	89.4269
GO:0055085	transmembrane transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	327.662	173.635	163.847	180.746	200.23	135.771
GO:0055085	transmembrane transport	biological_process	Escherichia	Escherichia coli	4.98622	0	3.56746	0	0	1.42055
GO:0055085	transmembrane transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.37418	1.60982	2.05965	3.62462	2.23375	1.89839
GO:0055088	lipid homeostasis	biological_process	Escherichia	Escherichia coli	0.065864	0	0.0611642	0	0	0
GO:0055114	oxidation-reduction process	biological_process	Clostridium	Clostridium thermocellum	194.097	2022.24	1047.27	6376.18	4231.67	7954.78
GO:0055114	oxidation-reduction process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	25.4756	25.6189	24.403	11.5876	15.8201	15.0285
GO:0055114	oxidation-reduction process	biological_process	Escherichia	Escherichia coli	1.07891	0	2.3085	0	0	0.127642
GO:0055114	oxidation-reduction process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	1.96396	14.9282	6.80542	3.85818	1.87576	6.44889
GO:0055129	L-proline biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	13.6731	70.1336	52.7249	157.35	138.219	140.283
GO:0060698	endoribonuclease inhibitor activity	molecular_function	Escherichia	Escherichia coli	0.260807	0	0	0	0	0
GO:0061077	chaperone-mediated protein folding	biological_process	Escherichia	Escherichia coli	1.00381	0	0.704742	0	0	0.13909
GO:0061489	guanine import into cell	biological_process	Escherichia	Escherichia coli	0.0803249	0	0	0	0	0.0530681
GO:0061593	sulfoquinovose isomerase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0826348	0	0	0
GO:0061594	6-deoxy-6-sulfofructose kinase activity	molecular_function	Escherichia	Escherichia coli	0.065062	0	0	0	0	0
GO:0061595	6-deoxy-6-sulfofructose-1-phosphate aldolase activity	molecular_function	Escherichia	Escherichia coli	0.066666	0	0	0	0	0
GO:0061596	3-sulfolactaldehyde reductase activity	molecular_function	Escherichia	Escherichia coli	0.0303315	0	0	0	0	0
GO:0061597	cyclic pyranopterin monophosphate synthase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	95.0111	26.1848	26.6875	16.0023	22.5185	15.4066
GO:0061597	cyclic pyranopterin monophosphate synthase activity	molecular_function	Escherichia	Escherichia coli	0.057868	0	0	0	0	0
GO:0061597	cyclic pyranopterin monophosphate synthase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.303388	0.349632	0.225036	0.589571	0.216899	0.685681
GO:0061599	molybdopterin molybdotransferase activity	molecular_function	Escherichia	Escherichia coli	0.0447681	0	0	0	0	0
GO:0061602	molybdenum cofactor cytidylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.169958	0	0.210286	0	0	0
GO:0061603	molybdenum cofactor guanylyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0743471
GO:0061603	molybdenum cofactor guanylyltransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.372502	0	0.303291	0	0.065745
GO:0061634	alpha-D-xyloside xylohydrolase	molecular_function	Escherichia	Escherichia coli	0.0112042	0	0.109744	0	0	0
GO:0061710	L-threonylcarbamoyladenylate synthase	molecular_function	Clostridium	Clostridium thermocellum	2.60104	14.9827	12.0892	30.5973	35.1039	40.2446
GO:0061710	L-threonylcarbamoyladenylate synthase	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	2.76653	6.19433	3.21126	2.47634	1.9306	2.07118
GO:0061710	L-threonylcarbamoyladenylate synthase	molecular_function	Escherichia	Escherichia coli	0.11491	0	0	0	0	0
GO:0061711	N(6)-L-threonylcarbamoyladenine synthase	molecular_function	Clostridium	Clostridium thermocellum	1.08943	15.2844	12.2832	27.7742	29.4735	31.8847
GO:0061711	N(6)-L-threonylcarbamoyladenine synthase	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	14.8289	7.57256	9.17675	5.33897	6.41807	10.4873
GO:0061711	N(6)-L-threonylcarbamoyladenine synthase	molecular_function	Escherichia	Escherichia coli	0.0562639	0	0	0	0	0
GO:0061711	N(6)-L-threonylcarbamoyladenine synthase	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.116927	0.192435	0.0620212	0.136711	0.178984	0.0888996
GO:0061712	tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.124479	0.240552	0.0442191	0	0.229186
GO:0065002	intracellular protein transmembrane transport	biological_process	Clostridium	Clostridium thermocellum	15.2639	39.6753	26.2876	208.83	146.464	110.982
GO:0065002	intracellular protein transmembrane transport	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	103.649	85.5668	97.0939	74.2249	89.538	73.691
GO:0065002	intracellular protein transmembrane transport	biological_process	Escherichia	Escherichia coli	0.130464	0	0.283087	0	0	0.0273587
GO:0065002	intracellular protein transmembrane transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.479884	0.348138	0.905871	0.768238	0.663957	0.866585
GO:0070006	metalloaminopeptidase activity	molecular_function	Clostridium	Clostridium thermocellum	8.05568	14.5777	9.44085	114.135	72.6202	68.1519
GO:0070006	metalloaminopeptidase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	36.2657	12.3271	7.96299	13.5957	15.1914	12.7792
GO:0070006	metalloaminopeptidase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.139965	0	0	0
GO:0070006	metalloaminopeptidase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0648189	0.248864	0.420978	0.862173	0.28917	0.172463
GO:0070008	serine-type exopeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0127353	0	0	0	0	0
GO:0070011	peptidase activity, acting on L-amino acid peptides	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0547174
GO:0070038	rRNA (pseudouridine-N3-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	2.94551	26.2976	22.5284	68.8634	60.7609	81.1661
GO:0070038	rRNA (pseudouridine-N3-)-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.344	48.6971	24.3665	16.1115	22.4702	17.825
GO:0070039	rRNA (guanosine-2'-O-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.0835087	0	0	0	0	0
GO:0070040	rRNA (adenine-C2-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	1.7819	11.4019	8.76191	33.2804	31.5624	33.2572
GO:0070041	rRNA (uridine-C5-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0773123	0	0	0
GO:0070043	rRNA (guanine-N7-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.0839462	3.13698	3.18419	13.7784	10.109	6.86629
GO:0070043	rRNA (guanine-N7-)-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	10.8064	4.82642	7.18093	6.27677	8.21336	3.74494
GO:0070043	rRNA (guanine-N7-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0.127353	0	0	0	0	0
GO:0070084	protein initiator methionine removal	biological_process	Clostridium	Clostridium thermocellum	8.05568	14.5777	9.44085	114.135	72.6202	68.1519
GO:0070084	protein initiator methionine removal	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	36.2657	12.3271	7.96299	13.5957	15.1914	12.7792
GO:0070084	protein initiator methionine removal	biological_process	Escherichia	Escherichia coli	0	0	0.139965	0	0	0
GO:0070084	protein initiator methionine removal	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0648189	0.248864	0.420978	0.862173	0.28917	0.172463
GO:0070125	mitochondrial translational elongation	biological_process	Escherichia	Escherichia coli	0.0469554	0	0	0	0	0
GO:0070180	large ribosomal subunit rRNA binding	molecular_function	Clostridium	Clostridium thermocellum	42.5327	96.4747	46.0233	629.277	477.498	339.832
GO:0070180	large ribosomal subunit rRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	72.3708	84.5407	72.6907	93.2416	126.52	113.958
GO:0070180	large ribosomal subunit rRNA binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	2.82992	3.35387	5.81164	8.00151	3.70547	7.43319
GO:0070181	small ribosomal subunit rRNA binding	molecular_function	Clostridium	Clostridium thermocellum	4.53786	13.9793	13.3934	45.292	45.279	39.6576
GO:0070181	small ribosomal subunit rRNA binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	16.9989	10.1952	10.9968	12.2321	13.6259	11.1628
GO:0070301	cellular response to hydrogen peroxide	biological_process	Escherichia	Escherichia coli	0.0263456	0	0.0546689	0	0	0.070046
GO:0070402	NADPH binding	molecular_function	Clostridium	Clostridium thermocellum	1.5856	8.00737	3.75655	20.4672	19.2295	15.9648
GO:0070402	NADPH binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	4.67053	4.78465	2.16822	5.04796	4.35649	2.48715
GO:0070402	NADPH binding	molecular_function	Escherichia	Escherichia coli	0.0464207	0	0	0	0	0.24639
GO:0070402	NADPH binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0	0	0.440599	0	0.071857
GO:0070403	NAD+ binding	molecular_function	Clostridium	Clostridium thermocellum	6.95135	45.9196	41.1006	72.7585	83.0025	129.835
GO:0070403	NAD+ binding	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	39.0074	73.6862	90.1666	38.8953	49.7602	41.129
GO:0070403	NAD+ binding	molecular_function	Escherichia	Escherichia coli	0.0402961	0	0	0	0	0
GO:0070417	cellular response to cold	biological_process	Escherichia	Escherichia coli	0.0285816	0	0	0	0	0.0380952
GO:0070453	regulation of heme biosynthetic process	biological_process	Escherichia	Escherichia coli	0	0	0.0573753	0	0	0
GO:0070475	rRNA base methylation	biological_process	Clostridium	Clostridium thermocellum	35.1663	237.713	263.565	597.064	572.21	797.742
GO:0070475	rRNA base methylation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	125.45	139.18	167.218	58.9941	68.6063	50.3356
GO:0070475	rRNA base methylation	biological_process	Escherichia	Escherichia coli	0.151123	0	0	0	0	0
GO:0070481	nuclear-transcribed mRNA catabolic process, non-stop decay	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.250124	0.192875	0.0532718	0.0465311	0.138637
GO:0070491	repressing transcription factor binding	molecular_function	Escherichia	Escherichia coli	0.0457645	0	0	0	0	0.0304632
GO:0070574	cadmium ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0070581	rolling circle DNA replication	biological_process	Escherichia	Escherichia coli	0.0241582	0	0	0	0	0
GO:0070588	calcium ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0880536	0	0	0	0	0
GO:0070590	spore wall biogenesis	biological_process	Clostridium	Clostridium thermocellum	0.109733	0.31598	0.33938	1.38467	1.63286	1.58095
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	4.73713	3.81776	2.90485	3.76601	3.22935	2.67336
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	molecular_function	Escherichia	Escherichia coli	0.03981	0	0	0	0	0
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.121496	0.350005	0.563694	0.559503	0.14465	0.107786
GO:0070677	rRNA (cytosine-2'-O-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	3.29626	6.52502	3.96548	21.0496	18.4026	15.9098
GO:0070677	rRNA (cytosine-2'-O-)-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	1.04605	1.09856	0.176907	1.79801	1.31821	0.824318
GO:0070677	rRNA (cytosine-2'-O-)-methyltransferase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.126794	0	0	0
GO:0070689	L-threonine catabolic process to propionate	biological_process	Escherichia	Escherichia coli	0.387941	0	0.127967	0	0	0
GO:0070814	hydrogen sulfide biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	0.170566	28.8948	17.7178	62.1958	54.7957	58.7528
GO:0070814	hydrogen sulfide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.405683	0	0	0	0	0
GO:0070929	trans-translation	biological_process	Clostridium	Clostridium thermocellum	4.47212	48.2579	43.9077	95.8748	84.4923	122.216
GO:0070929	trans-translation	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	75.2413	70.2379	87.0147	49.5934	62.1343	41.7394
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.250124	0.192875	0.0532718	0.0465311	0.138637
GO:0070967	coenzyme F420 binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.339924	0.246461	0	0.276647	0.0588891
GO:0070981	L-asparagine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.00423	11.0108	9.29827	27.4214	27.3095	32.9501
GO:0070981	L-asparagine biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	9.43158	29.0199	18.8658	23.913	24.1686	9.43613
GO:0071025	RNA surveillance	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.250124	0.192875	0.0532718	0.0465311	0.138637
GO:0071111	cyclic-guanylate-specific phosphodiesterase activity	molecular_function	Escherichia	Escherichia coli	0.543366	0	0.395628	0	0	0.189344
GO:0071249	cellular response to nitrate	biological_process	Escherichia	Escherichia coli	0.0463478	0	0	0	0	0
GO:0071250	cellular response to nitrite	biological_process	Escherichia	Escherichia coli	0.0463478	0	0	0	0	0
GO:0071266	'de novo' L-methionine biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.11693	7.52813	8.59258	20.3668	24.8744	25.0777
GO:0071266	'de novo' L-methionine biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.244572	0.104409	0.756839	0.862297	0.194176	0.506492
GO:0071271	1-butanol biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0471013	0	0	0	0	0.0626728
GO:0071310	cellular response to organic substance	biological_process	Escherichia	Escherichia coli	0.158827	0	0.0597659	0	0	0
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	molecular_function	Clostridium	Clostridium thermocellum	33.3844	226.311	254.804	563.783	540.647	764.485
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	125.45	139.18	167.218	58.9941	68.6063	50.3356
GO:0071436	sodium ion export	biological_process	Clostridium	Clostridium thermocellum	2.38104	17.75	13.8523	29.105	39.5093	53.9613
GO:0071436	sodium ion export	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	57.6596	26.7981	29.3111	17.74	17.493	12.5063
GO:0071436	sodium ion export	biological_process	Escherichia	Escherichia coli	0.111993	0	0	0	0	0
GO:0071454	cellular response to anoxia	biological_process	Escherichia	Escherichia coli	0.0263456	0	0.0546689	0	0	0.070046
GO:0071468	cellular response to acidic pH	biological_process	Escherichia	Escherichia coli	0	0	0.246461	0	0	0
GO:0071470	cellular response to osmotic stress	biological_process	Escherichia	Escherichia coli	0.132797	0	0	0	0	0.0773546
GO:0071474	cellular hyperosmotic response	biological_process	Escherichia	Escherichia coli	0.0972162	0	0.180425	0	0	0
GO:0071555	cell wall organization	biological_process	Clostridium	Clostridium thermocellum	83.1564	304.364	272.41	761.72	699.107	771.248
GO:0071555	cell wall organization	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	260.398	247.371	193.464	222.784	238.3	185.998
GO:0071555	cell wall organization	biological_process	Escherichia	Escherichia coli	2.93117	0	1.80782	0	0	0.640666
GO:0071577	zinc II ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0237208	0	0.0220119	0	0	0
GO:0071705	nitrogen compound transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0946559
GO:0071713	para-aminobenzoyl-glutamate hydrolase activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0557199
GO:0071805	potassium ion transmembrane transport	biological_process	Escherichia	Escherichia coli	0.207289	0	0	0	0	0
GO:0071897	DNA biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	18.8045	14.4913	14.601	13.952	18.8738	12.0016
GO:0071897	DNA biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0145824	0	0	0	0	0.0194033
GO:0071897	DNA biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.110778	0.060769	0.117502	0.145714	0.0847716	0.126316
GO:0071916	dipeptide transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.217035	0	0	0	0	0.0780984
GO:0071949	FAD binding	molecular_function	Escherichia	Escherichia coli	0.250016	0	0.646329	0	0	0.0304632
GO:0071949	FAD binding	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0465666	0.894313	0.691345	1.16711	0.852447	1.11433
GO:0071963	establishment or maintenance of cell polarity regulating cell shape	biological_process	Escherichia	Escherichia coli	0.0255679	0	0	0	0	0
GO:0071972	peptidoglycan L,D-transpeptidase activity	molecular_function	Escherichia	Escherichia coli	0.0143151	0	0	0	0	0
GO:0071973	bacterial-type flagellum-dependent cell motility	biological_process	Clostridium	Clostridium thermocellum	56.1354	142.275	107.883	1459.48	1423.45	1202.2
GO:0071973	bacterial-type flagellum-dependent cell motility	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	0.0268317	0	0	0	0	0
GO:0071973	bacterial-type flagellum-dependent cell motility	biological_process	Escherichia	Escherichia coli	0.291211	0	0.439426	0	0	0.108982
GO:0071978	bacterial-type flagellum-dependent swarming motility	biological_process	Escherichia	Escherichia coli	0.687416	0	0	0	0	0
GO:0072344	rescue of stalled ribosome	biological_process	Escherichia	Escherichia coli	0.188405	0	0	0	0	0
GO:0072348	sulfur compound transport	biological_process	Escherichia	Escherichia coli	0.300422	0	0	0	0	0
GO:0072531	pyrimidine-containing compound transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0219952	0	0	0	0	0.0584364
GO:0072592	oxygen metabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	5102.29	13939.3	11938.1	4792.25	5139.37	6668.11
GO:0075713	establishment of integrated proviral latency	biological_process	Escherichia	Escherichia coli	0.380626	0	0.0852059	0	0	0.155097
GO:0080100	L-glutamine:2-oxoglutarate aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	0.21441	2.05887	0.309565	6.04406	8.5926	8.3998
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	molecular_function	Clostridium	Clostridium thermocellum	4.86485	17.4735	15.7327	60.4082	63.6561	96.8323
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	50.0765	13.7323	32.6144	4.60319	5.75173	6.46044
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	molecular_function	Escherichia	Escherichia coli	0.142932	0	0	0	0	0
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.12485	0.0956809	0.138792	0.765801	0.267575	0.0995068
GO:0080146	L-cysteine desulfhydrase activity	molecular_function	Escherichia	Escherichia coli	0	0	0.0854314	0	0	0
GO:0080167	response to karrikin	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	15.1719	14.9984	15.1648	10.3004	13.3047	12.0245
GO:0080176	xyloglucan 1,6-alpha-xylosidase activity	molecular_function	Escherichia	Escherichia coli	0.0112042	0	0.109744	0	0	0
GO:0089714	UDP-N-acetyl-D-mannosamine dehydrogenase activity	molecular_function	Escherichia	Escherichia coli	0.130999	0	0.0405055	0	0	0
GO:0090071	negative regulation of ribosome biogenesis	biological_process	Clostridium	Clostridium thermocellum	1.39243	22.0746	15.9619	51.3402	47.5091	73.1241
GO:0090071	negative regulation of ribosome biogenesis	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	4.65391	2.99453	3.27865	1.59564	2.6893	3.31622
GO:0090305	nucleic acid phosphodiester bond hydrolysis	biological_process	Escherichia	Escherichia coli	0.206973	0	0.232208	0	0	0.0883498
GO:0090313	regulation of protein targeting to membrane	biological_process	Escherichia	Escherichia coli	0.0142665	0	0	0	0	0
GO:0090501	RNA phosphodiester bond hydrolysis	biological_process	Escherichia	Escherichia coli	0.0369908	0	0	0	0	0
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	Escherichia	Escherichia coli	1.1593	0	0	0	0	0
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	biological_process	Escherichia	Escherichia coli	0	0	0.187146	0	0	0.0883498
GO:0090540	bacterial cellulose biosynthetic process	biological_process	Escherichia	Escherichia coli	1.24636	0	0	0	0	0
GO:0090582	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity	molecular_function	Escherichia	Escherichia coli	0	0	0	0	0	0.0209879
GO:0090589	protein-phosphocysteine-trehalose phosphotransferase system transporter activity	molecular_function	Escherichia	Escherichia coli	0.0383275	0	0	0	0	0.0431401
GO:0090613	5'-deoxyadenosine deaminase activity	molecular_function	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0428724	0	0.0795225	0	0	0.0570135
GO:0090614	5'-methylthioadenosine deaminase activity	molecular_function	Clostridium	Clostridium thermocellum	2.16138	9.32091	3.97432	40.4601	33.0883	28.9094
GO:0097054	L-glutamate biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0766064	0	0	0	0	0
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.40476	16.8858	13.3064	39.3101	43.4919	37.9766
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	21.253	22.6975	16.1781	22.7479	24.3709	26.15
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	biological_process	Escherichia	Escherichia coli	0.118871	0	0	0	0	0
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.139675	0.167605	0.22675	0.303739	0.15587	0.232323
GO:0097098	DNA/RNA hybrid annealing activity	molecular_function	Escherichia	Escherichia coli	0.0579166	0	0.0179072	0	0	0.0256771
GO:0097171	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	biological_process	Escherichia	Escherichia coli	0.257234	0	0.282501	0	0	0
GO:0097173	N-acetylmuramic acid catabolic process	biological_process	Escherichia	Escherichia coli	0.133721	0	0	0	0	0
GO:0097175	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process	biological_process	Escherichia	Escherichia coli	0.065062	0	0	0	0	0
GO:0097264	self proteolysis	biological_process	Clostridium	Clostridium thermocellum	3.58145	16.78	9.44676	44.9418	44.3139	57.1423
GO:0097264	self proteolysis	biological_process	Escherichia	Escherichia coli	0.292548	0	0.320255	0	0	0.0456625
GO:0097588	archaeal or bacterial-type flagellum-dependent cell motility	biological_process	Clostridium	Clostridium thermocellum	13.7278	62.6596	40.8665	354.209	319.508	260.352
GO:0098655	cation transmembrane transport	biological_process	Escherichia	Escherichia coli	0.610712	0	0	0	0	0.0281348
GO:1900190	regulation of single-species biofilm formation	biological_process	Escherichia	Escherichia coli	0.0483165	0	0	0	0	0
GO:1900191	negative regulation of single-species biofilm formation	biological_process	Escherichia	Escherichia coli	1.52821	0	0	0	0	0
GO:1900751	4-(trimethylammonio)butanoate transport	biological_process	Escherichia	Escherichia coli	0.0349249	0	0	0	0	0
GO:1900753	doxorubicin transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0	0.391685	0.32851	0.1772	0	0.225143
GO:1901137	carbohydrate derivative biosynthetic process	biological_process	Clostridium	Clostridium thermocellum	2.87425	5.07356	2.99064	34.4445	23.9786	17.6544
GO:1901137	carbohydrate derivative biosynthetic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	16.418	12.2322	8.50232	16.6672	18.6474	15.7124
GO:1901137	carbohydrate derivative biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0289704	0	0	0	0	0
GO:1901137	carbohydrate derivative biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.119795	0.431311	0.305731	0.612874	0.320878	0.91629
GO:1901264	carbohydrate derivative transport	biological_process	Escherichia	Escherichia coli	0.0959524	0	0	0	0	0.0780984
GO:1901285	5,6,7,8-tetrahydromethanopterin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.170687	0.166391	0.479796	0.177249	0.232048	0.115288
GO:1901530	response to hypochlorite	biological_process	Escherichia	Escherichia coli	0.174382	0	0	0	0	0
GO:1901652	response to peptide	biological_process	Escherichia	Escherichia coli	0.0514031	0	0	0	0	0
GO:1901682	sulfur compound transmembrane transporter activity	molecular_function	Escherichia	Escherichia coli	0.300422	0	0	0	0	0
GO:1902021	regulation of bacterial-type flagellum-dependent cell motility	biological_process	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:1902201	negative regulation of bacterial-type flagellum-dependent cell motility	biological_process	Escherichia	Escherichia coli	0.519645	0	0	0	0	0.122855
GO:1902209	negative regulation of bacterial-type flagellum assembly	biological_process	Escherichia	Escherichia coli	0.0632148	0	0	0	0	0
GO:1902475	L-alpha-amino acid transmembrane transport	biological_process	Escherichia	Escherichia coli	0.707175	0	0.523098	0	0	0.179351
GO:1902599	sulfathiazole transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0266372	0	0.0494366	0	0	0
GO:1902760	Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process	biological_process	Escherichia	Escherichia coli	0.169958	0	0.210286	0	0	0
GO:1902765	L-arginine import into cell	biological_process	Escherichia	Escherichia coli	0.0835087	0	0.154985	0	0	0
GO:1902777	6-sulfoquinovose(1-) catabolic process	biological_process	Escherichia	Escherichia coli	0.162084	0	0.0826348	0	0	0
GO:1903401	L-lysine transmembrane transport	biological_process	Escherichia	Escherichia coli	0.129711	0	0	0	0	0
GO:1903506	regulation of nucleic acid-templated transcription	biological_process	Escherichia	Escherichia coli	0.0604685	0	0	0	0	0
GO:1903658	positive regulation of type IV pilus biogenesis	biological_process	Escherichia	Escherichia coli	0.201602	0	0.187552	0	0	0
GO:1903716	guanine transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0803249	0	0	0	0	0.0530681
GO:1903785	L-valine transmembrane transport	biological_process	Escherichia	Escherichia coli	0.26941	0	0	0	0	0
GO:1903791	uracil transmembrane transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.0548468
GO:1903825	organic acid transmembrane transport	biological_process	Escherichia	Escherichia coli	0.0374282	0	0.0694638	0	0	0
GO:1903874	ferrous iron transmembrane transport	biological_process	Escherichia	Escherichia coli	0.135349	0	0	0	0	0
GO:1990663	dihydroorotate dehydrogenase (fumarate) activity	molecular_function	Coprothermobacter	Coprothermobacter proteolyticus	0.864033	0.484005	0.13365	0.257804	0.353627	0.431174
GO:2000142	regulation of DNA-templated transcription, initiation	biological_process	Escherichia	Escherichia coli	0	0	0.0968433	0	0	0
GO:2000143	negative regulation of DNA-templated transcription, initiation	biological_process	Escherichia	Escherichia coli	1.42047	0	0.406363	0	0	0
GO:2000144	positive regulation of DNA-templated transcription, initiation	biological_process	Escherichia	Escherichia coli	0.090727	0	0	0	0	0
GO:2000145	regulation of cell motility	biological_process	Escherichia	Escherichia coli	0.16534	0	0	0	0	0
GO:2000147	positive regulation of cell motility	biological_process	Escherichia	Escherichia coli	1.05166	0	0	0	0	0
GO:2000186	negative regulation of phosphate transmembrane transport	biological_process	Escherichia	Escherichia coli	0	0	0	0	0	0.112378
GO:2000186	negative regulation of phosphate transmembrane transport	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.0476602	0.184127	1.33312	0.689474	0.256333	0.636106
GO:2000678	negative regulation of transcription regulatory region DNA binding	biological_process	Escherichia	Escherichia coli	0.0430911	0	0	0	0	0
GO:2000884	glucomannan catabolic process	biological_process	Clostridium	Clostridium thermocellum	7.87794	11.7939	11.5945	20.9763	16.3192	17.9495
GO:2001059	D-tagatose 6-phosphate catabolic process	biological_process	Clostridium	Clostridium thermocellum	9.86686	28.7165	21.6438	133.033	107.045	143.081
GO:2001059	D-tagatose 6-phosphate catabolic process	biological_process	Coprothermobacter	Coprothermobacter proteolyticus	125.074	105.814	111.725	74.0842	99.1241	73.0471
GO:2001059	D-tagatose 6-phosphate catabolic process	biological_process	Escherichia	Escherichia coli	0.191467	0	0.0810561	0	0	0
GO:2001070	starch binding	molecular_function	Clostridium	Clostridium thermocellum	11.5	46.4104	40.8239	383.819	405.859	540.485
GO:2001118	tetrahydromethanopterin biosynthetic process	biological_process	Methanothermobacter	Methanothermobacter thermautotrophicus	0.265619	0.71938	1.42789	0.202194	0.11852	0.439097
GO:2001295	malonyl-CoA biosynthetic process	biological_process	Escherichia	Escherichia coli	0.0405149	0	0.150294	0	0	0.0539089