Mercurial > repos > guerler > spring_minz
view test-data/model/ACE2_HUMAN.hhr @ 0:0fdd5f2a7a53 draft
"planemo upload commit 6158473dbced09024b0a805a7df2c93d47705d87"
| author | guerler |
|---|---|
| date | Tue, 23 Mar 2021 13:56:20 +0000 |
| parents | |
| children |
line wrap: on
line source
Query sp|Q9BYF1|ACE2_HUMAN Angiotensin-converting enzyme 2 OS=Homo sapiens (Human) OX=9606 GN=ACE2 PE=1 SV=2 Match_columns 805 No_of_seqs 1 out of 1 Neff 1 Searched_HMMs 82491 Date Sat Oct 10 23:55:36 2020 Command hhsearch -e 0.001 -i /galaxy-repl/main/files/046/047/dataset_46047478.dat -d hhdb -o /galaxy-repl/main/files/046/091/dataset_46091622.dat No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6M18_B Sodium-dependent neutra 100.0 4E-194 5E-199 1504.8 0.0 804 2-805 3-814 (814) 2 1R42_A angiotensin I convertin 100.0 3.4E-78 4.2E-83 582.0 0.0 615 1-615 1-615 (615) 3 6LZG_A Angiotensin-converting 100.0 5.4E-74 6.6E-79 545.9 0.0 597 19-615 1-597 (597) 4 3D0I_B Crystal structure of sp 100.0 1.2E-73 1.5E-78 545.2 0.0 596 20-615 2-597 (597) 5 5AMB_A ANGIOTENSIN-CONVERTING 100.0 1.2E-69 1.5E-74 524.2 0.0 595 20-625 12-614 (629) 6 6H5W_A Angiotensin-converting 100.0 4.4E-61 5.4E-66 455.7 0.0 579 22-613 5-588 (591) 7 6S1Y_A Angiotensin-converting 100.0 4.6E-59 5.5E-64 450.3 0.0 579 21-610 11-600 (621) 8 4CA5_A ANGIOTENSIN-CONVERTING 100.0 3.9E-58 4.7E-63 435.5 0.0 578 22-612 5-587 (589) 9 5A2R_A ANGIOTENSIN-CONVERTING 100.0 2.8E-56 3.4E-61 425.1 0.0 579 22-611 5-594 (598) 10 4ASR_A ANGIOTENSIN-CONVERTING 100.0 2.9E-56 3.5E-61 426.4 0.0 578 22-611 6-595 (598) 11 4CA7_A ANGIOTENSIN-CONVERTING 100.0 3.2E-56 3.9E-61 426.0 0.0 578 22-611 6-595 (598) 12 2C6F_A ANGIOTENSIN-CONVERTING 100.0 2.3E-52 2.7E-57 400.7 0.0 579 22-611 14-599 (612) 13 5GIV_E Carboxypeptidase; M32 c 100.0 4.3E-52 5.2E-57 399.6 0.0 474 19-597 3-502 (503) 14 5GIV_F Carboxypeptidase; M32 c 100.0 4.3E-52 5.2E-57 399.6 0.0 474 19-597 3-502 (503) 15 3HQ2_B Bacillus subtilis M32 c 100.0 1.1E-47 1.3E-52 361.2 0.0 473 22-597 3-500 (501) 16 1K9X_B m32 carboxypeptidase; H 100.0 1.1E-46 1.3E-51 357.8 0.0 470 20-593 4-499 (499) 17 1KA2_A M32 carboxypeptidase; H 100.0 1.1E-46 1.3E-51 357.8 0.0 470 20-593 4-499 (499) 18 5E3X_A Thermostable carboxypep 100.0 2.4E-46 2.9E-51 356.7 0.0 456 27-597 2-486 (489) 19 3HOA_A Thermostable carboxypep 100.0 1.1E-45 1.3E-50 356.9 0.0 468 22-594 3-507 (509) 20 3DWC_B Metallocarboxypeptidase 100.0 2E-44 2.4E-49 343.9 0.0 459 23-593 3-501 (505) 21 5WVU_C Thermostable carboxypep 100.0 8.4E-44 1E-48 344.0 0.0 469 22-595 3-508 (510) 22 3SKS_A Putative Oligoendopepti 100.0 1.7E-38 2.1E-43 300.7 0.0 506 22-600 36-564 (567) 23 3AHN_A Oligopeptidase; HYDROLA 100.0 2.6E-38 3.2E-43 299.3 0.0 505 22-601 33-562 (564) 24 2QR4_A Peptidase M3B, oligoend 100.0 2E-33 2.4E-38 267.6 0.0 506 23-603 34-578 (587) 25 2O36_A Thimet oligopeptidase ( 99.9 5E-30 6.1E-35 254.5 0.0 518 26-588 47-660 (674) 26 3CE2_A Crystal structure of pu 99.9 1.1E-29 1.4E-34 244.3 0.0 507 23-601 67-609 (618) 27 2O3E_A Neurolysin (E.C.3.4.24. 99.9 9.4E-29 1.1E-33 246.4 0.0 515 31-588 68-676 (678) 28 5LV0_A Neurolysin, mitochondri 99.9 6.2E-28 7.6E-33 240.2 0.0 504 41-589 83-682 (686) 29 1S4B_P Thimet oligopeptidase ( 99.9 1.6E-27 2E-32 236.8 0.0 516 26-588 47-660 (674) 30 5L44_A K-26 dipeptidyl carboxy 99.8 4.9E-23 6E-28 205.4 0.0 512 28-589 76-681 (683) 31 5L43_B K-26 dipeptidyl carboxy 99.8 4.9E-23 6E-28 205.4 0.0 512 28-589 76-681 (683) 32 1Y79_1 Peptidyl-Dipeptidase Dc 99.4 4.5E-17 5.4E-22 163.2 0.0 501 41-588 70-676 (680) 33 4KA7_A Oligopeptidase A, short 99.4 5.8E-17 7.1E-22 163.7 0.0 407 144-589 239-706 (714) 34 2KNC_B Integrin alpha-IIb, Int 92.7 0.036 4.4E-07 45.3 0.0 31 733-763 2-32 (79) 35 2L8S_A Integrin alpha-1; Integ 87.6 0.29 3.5E-06 40.2 0.0 43 736-778 4-48 (54) 36 2N2A_B Receptor tyrosine-prote 86.5 0.38 4.6E-06 38.4 0.0 30 742-771 9-38 (58) 37 2KNC_A Integrin alpha-IIb, Int 85.7 0.45 5.4E-06 38.7 0.0 40 735-774 6-47 (54) 38 2M3E_A Integrin alpha-L; integ 85.4 0.48 5.8E-06 38.2 0.0 39 736-774 7-47 (50) 39 6J8H_C Sodium channel subunit 84.3 0.6 7.2E-06 37.2 0.0 8 591-598 64-71 (215) 40 2N9Y_B Integrin alpha-IIb, Int 84.0 0.63 7.7E-06 35.0 0.0 30 737-766 5-34 (43) 41 6JXR_n T-cell surface glycopro 83.4 0.7 8.5E-06 38.0 0.0 7 591-597 154-160 (291) 42 2K9J_A Integrin alpha-IIb ligh 83.0 0.74 9E-06 35.9 0.0 39 732-770 1-41 (42) 43 2N5S_A Epidermal growth factor 82.7 0.79 9.6E-06 34.0 0.0 10 744-753 8-17 (54) 44 4UM8_D INTEGRIN ALPHA-V, INTEG 80.8 1 1.3E-05 49.0 0.0 25 738-762 705-729 (788) 45 4UM8_B INTEGRIN ALPHA-V, INTEG 78.7 1.4 1.7E-05 48.1 0.0 25 738-762 705-729 (788) 46 1AFO_A GLYCOPHORIN A; INTEGRAL 75.9 1.9 2.3E-05 35.5 0.0 37 732-771 4-40 (40) 47 6A69_B Plasma membrane calcium 75.9 1.9 2.3E-05 35.7 0.0 15 742-756 224-238 (282) 48 6AGF_B Sodium channel protein 75.3 2 2.5E-05 35.7 0.0 22 773-795 192-213 (218) 49 6J8J_B Sodium channel subunit 75.3 2 2.5E-05 35.7 0.0 22 773-795 192-213 (218) 50 6C14_A Protocadherin-15, LHFPL 74.5 2.2 2.7E-05 40.6 0.0 23 738-760 238-260 (337) 51 6UJB_B Integrin alpha-V, Integ 73.3 2.5 3E-05 45.8 0.0 25 738-762 637-661 (727) 52 6UJA_B Integrin alpha-V, Integ 73.3 2.5 3E-05 45.8 0.0 25 738-762 637-661 (727) 53 2M20_A Epidermal growth factor 72.7 2.6 3.2E-05 32.9 0.0 10 744-753 5-14 (60) 54 5OR7_C Capsid protein, CMRF35- 72.6 2.7 3.2E-05 38.5 0.0 6 592-597 52-57 (330) 55 2MFR_A Insulin receptor (E.C.2 69.0 3.6 4.4E-05 33.9 0.0 38 740-779 15-52 (57) 56 4U0Q_B Plasmodium falciparum R 67.3 4.2 5.1E-05 33.8 0.0 13 744-756 211-223 (269) 57 5A2F_A CD166 ANTIGEN; CELL ADH 63.7 5.5 6.7E-05 38.7 0.0 11 589-599 442-452 (583) 58 2KLU_A T-cell surface glycopro 59.8 7.3 8.8E-05 30.3 0.0 9 744-752 12-20 (70) 59 6ENY_C Beta-2-microglobulin, T 58.0 8.2 9.9E-05 37.8 0.0 9 539-547 248-256 (428) 60 1S7Q_A H-2 class I histocompat 57.9 8.2 0.0001 37.5 0.0 11 742-752 285-295 (348) 61 1S7S_A H-2 class I histocompat 57.9 8.2 0.0001 37.5 0.0 11 742-752 285-295 (348) 62 2WY3_A MHC CLASS I POLYPEPTIDE 57.3 8.6 0.0001 35.8 0.0 9 591-599 214-222 (319) 63 6JXR_f T-cell surface glycopro 55.1 9.8 0.00012 32.9 0.0 14 741-754 130-143 (207) 64 3LB6_C Interleukin-13, Interle 54.8 10 0.00012 33.3 0.0 18 670-687 293-310 (380) 65 3LB6_D Interleukin-13, Interle 54.8 10 0.00012 33.3 0.0 18 670-687 293-310 (380) 66 6FGB_A IgG receptor FcRn large 49.5 14 0.00017 35.5 0.0 10 776-785 311-320 (342) 67 4NKQ_B Cytokine receptor commo 46.9 16 0.0002 32.2 0.0 18 670-687 186-203 (305) 68 6JXR_g T-cell surface glycopro 43.8 20 0.00024 29.7 0.0 10 743-752 117-126 (182) 69 5EH6_A Glycophorin-A; Receptor 43.3 20 0.00025 28.5 0.0 24 741-766 4-27 (30) 70 5EH4_C Glycophorin-A; Receptor 43.3 20 0.00025 28.5 0.0 24 741-766 4-27 (30) 71 2XQ2_A SODIUM/GLUCOSE COTRANSP 39.8 25 0.0003 38.0 0.0 33 739-773 548-580 (593) 72 2RDD_B Acriflavine resistance 39.2 26 0.00031 26.1 0.0 20 756-775 12-31 (37) 73 6CPL_A HLA class II histocompa 39.1 26 0.00031 31.3 0.0 8 591-598 118-125 (229) 74 6EJ2_A Beta-secretase 1 (E.C.3 38.0 28 0.00034 35.2 0.0 15 736-750 452-466 (501) 75 6ENY_F Beta-2-microglobulin, T 37.9 28 0.00034 33.9 0.0 6 592-597 215-220 (341) 76 5XTH_0 NADH dehydrogenase [ubi 37.1 29 0.00035 33.4 0.0 32 732-763 65-96 (144) 77 5B1A_D Cytochrome c oxidase su 33.8 36 0.00044 33.1 0.0 32 732-763 68-99 (147) 78 6PY2_A HLA class II histocompa 33.3 37 0.00045 31.4 0.0 9 591-599 143-151 (254) 79 6GJE_A Protein amnionless, Cub 33.2 37 0.00045 37.8 0.0 18 783-800 399-416 (453) 80 6C13_A Protocadherin-15; PCDH1 32.9 38 0.00046 35.0 0.0 13 693-705 508-520 (660) 81 5DJQ_P Cbb3-type cytochrome c 32.8 38 0.00046 27.7 0.0 24 748-771 7-35 (36) 82 1CD1_A CD1; CD1, IMMUNOLOGY, M 32.5 39 0.00047 31.8 0.0 7 592-598 217-223 (315) 83 6AT5_A HLA class I histocompat 29.9 46 0.00056 33.0 0.0 8 591-598 238-245 (362) 84 4JIX_A Uncharacterized protein 28.2 51 0.00062 27.7 0.0 41 371-421 68-108 (112) 85 4JIX_B Projannalysin; Hydrolas 28.2 51 0.00062 27.7 0.0 41 371-421 68-108 (112) 86 6IDF_E Nicastrin, Presenilin-1 27.6 53 0.00065 31.8 0.0 16 733-748 9-24 (129) 87 6IVA_D Oxaloacetate decarboxyl 26.5 58 0.0007 29.7 0.0 27 738-764 31-57 (104) 88 6IWW_B Oxaloacetate decarboxyl 26.5 58 0.0007 29.7 0.0 27 738-764 31-57 (104) 89 6BRJ_A Epithelial discoidin do 25.3 63 0.00076 37.1 0.0 7 602-608 254-260 (876) 90 3EHB_B Cytochrome c oxidase su 25.2 63 0.00076 33.8 0.0 47 725-771 47-93 (298) 91 6PY2_B HLA class II histocompa 24.3 67 0.00082 30.1 0.0 11 745-755 235-245 (261) 92 1Q5B_C EP-cadherin, ectodomain 24.1 68 0.00082 35.0 0.0 12 155-166 149-160 (880) 93 2JO1_A Phospholemman; FXYD1, N 23.9 69 0.00084 29.3 0.0 30 747-776 20-49 (72) 94 2KV5_A Putative uncharacterize 23.5 71 0.00086 25.4 0.0 27 745-771 4-31 (33) 95 6BSD_A Epithelial discoidin do 23.3 72 0.00088 36.6 0.0 7 602-608 254-260 (876) 96 6KOE_F AA3-600 quinol oxidase 22.6 76 0.00092 33.7 0.0 40 732-771 11-50 (296) 97 6KOB_B AA3-600 quinol oxidase 22.6 76 0.00092 33.7 0.0 40 732-771 11-50 (296) 98 1Q90_G Apocytochrome f, Cytoch 22.4 78 0.00094 26.3 0.0 29 744-772 5-33 (37) 99 2GSM_B Cytochrome c oxidase su 21.9 80 0.00097 31.8 0.0 6 721-726 4-9 (262) 100 3HB3_B Cytochrome c oxidase su 21.5 83 0.001 32.9 0.0 47 725-772 47-94 (298) 101 5X5V_A GD; herpes simplex viru 20.1 93 0.0011 35.6 0.0 28 742-769 355-382 (402) No 1 >6M18_B Sodium-dependent neutral amino acid transporter; ACE2-B0AT1 complex, MEMBRANE PROTEIN; HET: 3PH, NAG; 2.9A {Homo sapiens} Probab=100.00 E-value=3.9e-194 Score=1504.77 Aligned_cols=804 Identities=100% Similarity=1.532 Sum_probs=737.6 Template_Neff=7.700 Q sp|Q9BYF1|ACE2 2 SSSSWLLLSLVAVTAA--------QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFL 73 (805) Q Consensus 2 sssswlllslvavtaa--------qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsafl 73 (805) +.+.|++++||+++++ +++.|++|++||++++.+++++.+++++|+|+|+||+|+++.+.++.+..+|++|+ T Consensus 3 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~e~~a~~~L~~~d~~~~~l~~~~~~A~w~y~tn~t~e~~~~~~ea~~~ls~f~ 82 (814) T 6M18_B 3 SSSSWLLLSLVAVTAAWSHPQFEKQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFL 82 (814) T ss_dssp ---------------------------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCSTTHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHhcCCcccCCCCCcHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHH Confidence 4678999999999999 99999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 74 KEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMA 153 (805) Q Consensus 74 keqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneima 153 (805) ++.++.++.|+++.+++-..|.||+.+++.|...|++++.++++.+++.|+++|+++.+|.+++|.+|+.++|++..+|+ T Consensus 83 ~~~~~~~~~~~~~~~~d~~~kr~L~~l~~~~~~~Ls~~~~~~l~~~~~~m~~~ys~~~v~~~~~p~~~~~L~~~l~~il~ 162 (814) T 6M18_B 83 KEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMA 162 (814) T ss_dssp HHHHHHGGGSCTTSCCCHHHHHHHHHHHCCGGGGSCTTHHHHHHHHHHHHHHHHHHCEEECSSCTTCEEECCCCCHHHHH T ss_pred HHHHHHHhhcChhhcCCHHHHHHHHHHHHcCccCCCHHHHHHHHHHHHHHHHHHHcCCcCCCCCCCcccccCHHHHHHHh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 154 NSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEI 233 (805) Q Consensus 154 nsldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeei 233 (805) ++-|+.+|.++|+.|++.+++.++|+|+++|-++|++|+.+.|+||+|||+.+|+.++.++|||++.++.+.++..+++| T Consensus 163 ~s~D~~~R~~aw~a~~~~~~~~~~~~l~~lv~lrne~Akl~Gy~sy~d~~l~~~e~~~~~~~~ys~~~~~~~Le~L~~~i 242 (814) T 6M18_B 163 NSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEI 242 (814) T ss_dssp HCCCHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHTTTCSSHHHHHGGGGCBCSSSSCCBCSSHHHHHHHHHHHHH T ss_pred cCCCHHHHHHHHHHHHhHhcHHhHHHHHHHHHHHHHHHHhCCCCCHHHHHHhhhccCCCCCCCCCHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 234 KPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEK 313 (805) Q Consensus 234 kplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaek 313 (805) +|+|+.||+|+|.++...|++.|++-+++|+|+||+|||++|+++|.+++||.+++++|+|++|+.+.|...++|+.+++ T Consensus 243 ~ply~~l~ayvr~kl~~~yg~~i~~~~~iPahllg~~~~~~w~~~y~~~~p~~~~~~~dv~~~~~~~~~t~~~~~~~a~~ 322 (814) T 6M18_B 243 KPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEK 322 (814) T ss_dssp HHHHHHHHHHHHHHHTTTSTTSSCTTBCEEGGGSSSSSSSCCGGGHHHHCSSTTSCCCCCTTHHHHTTCCTTHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHCcccCCCCCCCcHHHhHhhhHHHHHHhhcccCCCCCCCCCCCcHHHHhcCCCHHHHHHHHHH Confidence 99999999999999999888777888999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 314 FFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR 393 (805) Q Consensus 314 ffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllr 393 (805) ||.++|++.|+++||++++++.|+.-..++|||++||.+.+|+||+||++++|+||+|.||||||++|.|.|..||++.| T Consensus 323 ~f~~lgl~~~~~~fw~~s~~~r~~K~~~~~C~~~a~d~~~~d~rI~~~~~~~~~d~~tl~HE~GHa~h~~~~~~qp~~~~ 402 (814) T 6M18_B 323 FFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR 402 (814) T ss_dssp HHHHTTCCCCCSSTTTSCBCSCCCSSCCCCCSCEEEECSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHTTSTTSCGGGC T ss_pred HHHhcCCCCCCCCcccHHhccCCCCCCCCCcCchHhcCCCCCeEEEeecCCCHHHHHHHHHHHHHHHHHHHhccCCchhc Confidence 99999999999999999999999988899999999999889999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 394 NGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQW 473 (805) Q Consensus 394 nganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqw 473 (805) .|++.+||||++++|++++.+|+||+++|++.++++++.+.+||+|++++|++++++||.+++++|||.+|.|++++++| T Consensus 403 ~~a~~~f~Eavsel~el~~~~p~~L~~~~ll~~~~~~~~~~~in~ll~~aL~~l~~lp~~~~~d~~r~~~f~g~i~~~~l 482 (814) T 6M18_B 403 NGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQW 482 (814) T ss_dssp SCSSTTSHHHHHHHHHHHSSSHHHHHHHTCSCSSCCCCTTHHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHTSSCGGGH T ss_pred cCCChHHHHHHHHHHHHHhhCHHHHHHccCcCCCCCCCcHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHhcCCCCHHHH Confidence 99999999999999999999999999999999988888899999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 474 MKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQK 553 (805) Q Consensus 474 mkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqk 553 (805) ++.||++.++..|++.|+++++++|||++.+|+.+++.+++|++.++++||+.+++|+.+.|+||||+||+++++++|++ T Consensus 483 n~~w~el~~~y~Gv~~p~~~~~~~~d~~~~~Hi~~~~~Yy~Y~~s~i~a~qi~~~l~~~~~~~~pl~~c~~~~s~~ag~~ 562 (814) T 6M18_B 483 MKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQK 562 (814) T ss_dssp HHHHHHHCCCCCCEECSSCCCTTCCGGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCTTHHHH T ss_pred HHHHHHHHHHHcCCCCCCCCCccCCCHHHHhhhhcCcchHHHHHHHHHHHHHHHHHHHHcccCCCchhCCCCCCHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 554 LFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAY 633 (805) Q Consensus 554 lfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadqsikvrislksalgdkay 633 (805) |.+||+.|.|.||+-+++.+.|...+++.|+++||+||.+||+.+|++..+||.++|+||.+++||||||||+||||+|| T Consensus 563 l~~lL~~G~S~~~~ell~~~~G~~~~s~~~ll~yf~pL~~wL~~~n~~~~~gw~~~~~~~~~~~~~~~~~~~~~~~~~~~ 642 (814) T 6M18_B 563 LFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAY 642 (814) T ss_dssp HHHHHTTTTSSCHHHHHHTTTSCSSCCSHHHHHHTHHHHHHHHHHTSSSCCSCBTTCCTTSSSCEEEEECHHHHTSSSCC T ss_pred HHHHHhcCCCCCHHHHHHHHHCCCCCCcHHHHHhHHHHHHHHHHhccCCCCCCCCCCCCCCCCcceeEEEcchhcCcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 634 EWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRIND 713 (805) Q Consensus 634 ewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtevekairmsrsrind 713 (805) +||+||||||||++|||||+||.++|+|.+.|..+||.|.|.+|||||.|+||.|.|+|++||+.|||+||||||.|||+ T Consensus 643 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 722 (814) T 6M18_B 643 EWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRIND 722 (814) T ss_dssp CCCHHHHHHHHHHHHHHHHHHHHHTSCCCCCCCGGGEEEECCCTTSEEEEEEEETTEEEEECCHHHHHHHHHHTHHHHHH T ss_pred cCChhhHHHHHHHHHHHHHHHHHHHccceeecccccEEEecCCCcEEEEEEEecCCCccccCCHHHHHHHHHhchhhhhh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 714 AFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNP 793 (805) Q Consensus 714 afrlndnsleflgiqptlgppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkknkarsgenpyasidiskgennp 793 (805) ||+|+|++|||+||+|||+||.+|||.|||||||||||++||||++||++|||+||||+|+++++|||+++|+++|++|| T Consensus 723 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 802 (814) T 6M18_B 723 AFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNP 802 (814) T ss_dssp HHTCCSSSEECSSCCCCCCCCCCCSSCTHHHHHHHHHHHHHHHHHHHHTTTTTTC------------------------- T ss_pred hhhcCCCceeecccCCCCCCCCCCCcchHHHHHHHHHHHHHHHHHHHHHhChhhHHHHccccCCCCCCccccccCCccCc Confidence 99999999999999999999999999999999999999999999999999999999999999899999999999999999 Q sp|Q9BYF1|ACE2 794 GFQNTDDVQTSF 805 (805) Q Consensus 794 gfqntddvqtsf 805 (805) |||++||+|||| T Consensus 803 ~~~~~~~~~~~~ 814 (814) T 6M18_B 803 GFQNTDDVQTSF 814 (814) T ss_dssp ------------ T ss_pred ccCCCcccccCC Confidence 999999999998 No 2 >1R42_A angiotensin I converting enzyme 2; zinc metallopeptidase domain, collectrin homology; HET: NAG; 2.2A {Homo sapiens} SCOP: d.92.1.5 Probab=100.00 E-value=3.4e-78 Score=581.98 Aligned_cols=615 Identities=100% Similarity=1.557 Sum_probs=553.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 1 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLA 80 (805) Q Consensus 1 msssswlllslvavtaaqstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstla 80 (805) |++++|+|++||+++++.+..++.+.+++++++.+...+....+++.|.+.++.+++..+....+..+.+.++.+..+.. T Consensus 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~ 80 (615) T 1R42_A 1 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLA 80 (615) T ss_dssp ------------------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred ChhHHHHHHHHHHHHhcCCCcHHHHHHHHHHHHHHHHHHHhHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 78999999999999999999999999999999999999999999999999999999999988889999999999999988 Q sp|Q9BYF1|ACE2 81 QMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNE 160 (805) Q Consensus 81 qmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldyne 160 (805) ..|.+..+.+-..+-+|+.+...+...|+++..++++..++.|...|++..+|.++.|.+|+.+.|.+..+|+++-|... T Consensus 81 ~~~~~~~~~~~~~~~~l~~~~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~ 160 (615) T 1R42_A 81 QMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNE 160 (615) T ss_dssp TTSCSTTCCCHHHHHHHHHHTCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEEETTEEEEEEETTTBHHHHHHHCCCHHH T ss_pred hhCChhhcCCHHHHHHHHHHHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCcccccChhHHHHHhcCCCHHH Confidence 88887766666777788877777777888888888889999999999999999888888899888999999999999999 Q sp|Q9BYF1|ACE2 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL 240 (805) Q Consensus 161 rlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehl 240 (805) |-.+|++|+...++.+.+++.+.+-+++++|+...|++|.|||..++++++++++||+..++.+.++..++.++|+|+.+ T Consensus 161 R~~~~~~~~~~~~~~~~~~l~~lv~lr~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~y~~~~~~~~l~~l~~~v~p~~~~~ 240 (615) T 1R42_A 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL 240 (615) T ss_dssp HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTTCBCSCTTTCBCSHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhHHhHHHHHHHHHHHHHHHHHCCCCCHHHHHHHhhccCCCCCCCCChhHHHHHHHHHHHHHHHHHHHH Confidence 99999999998889999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 241 HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL 320 (805) Q Consensus 241 hayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvgl 320 (805) |+|+|.++...|+.-+++-+..|+|++|.||+..|+.+|....|+.+.+..+++..++.+.|..+++++.++++|-++|+ T Consensus 241 ~~~~~~~~~~~~~~~~~~~~l~p~d~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 320 (615) T 1R42_A 241 HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL 320 (615) T ss_dssp HHHHHHHHHHHSTTTSCTTBCEEGGGSSSSSCSCCGGGHHHHCTTTTSCCCCCTTTTGGGTCCHHHHHHHHHHHHHTTTC T ss_pred HHHHHHHHHHHCccCCCCCCCccHHHccccchhcchhhHhccCCCCCCCCCCCcHHHHHCCCCHHHHHHHHHHHHHHcCC Confidence 99999987766664445567889999999999999999999999999988999999999999999999999999999999 Q sp|Q9BYF1|ACE2 321 PNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (805) Q Consensus 321 pnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegf 400 (805) ..++..+|.++++..+|....+.|+|.+|+.+.++.||++|...+.+|+.|.+||+||..|.+.+..||++.+.+++.+| T Consensus 321 ~~~~~~~w~~~~~~r~~K~~~~~c~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~ 400 (615) T 1R42_A 321 PNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (615) T ss_dssp CCCCTTHHHHCBCSCCCTTCCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTH T ss_pred ccCCcchhhhhccCCCCCCCCCccccchhcCCCCceEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCCchHcCCCChHH Confidence 99999999999998888877899999999887789999999999999999999999999999999899999998899999 Q sp|Q9BYF1|ACE2 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (805) Q Consensus 401 heavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwem 480 (805) +|+++++|+..+.+|.+|+.++++....+...+.+++.++++++..+..+|+.++++.|+|.+|.|+++.+++-+.||+. T Consensus 401 ~E~~s~~~e~~~~~~~~l~~~~~~~~~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~~~~~~~~l 480 (615) T 1R42_A 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (615) T ss_dssp HHHHHHHHHHHHHSHHHHHHTTSSCTTSCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTCSCGGGHHHHHHHH T ss_pred HHHHHHHHHHHhcCHHHHHHcCCCCcccCCCcHHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHcCCCCHHHHHHHHHHH Confidence 99999999999999999999999876655555668889999999999999999999999999999999889999999999 Q sp|Q9BYF1|ACE2 481 KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL 560 (805) Q Consensus 481 kreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl 560 (805) .++..|+..|++.++...++++..|...+..++.|....+..+|+-+++|+...++||||.|++.++.++|+++.++|+. T Consensus 481 ~~~y~g~~~~~~~~~~~~~~~~~~H~~~~~~Yy~Y~~s~~~a~ql~~~~~~~~~~~~~l~~~~~~~~~~~g~~~~~~l~~ 560 (615) T 1R42_A 481 KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL 560 (615) T ss_dssp CCCCCCEECSSCCCTTCCGGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHTTTCCSCGGGCCCTTCHHHHHHHHHHHTT T ss_pred HHHHcCCCCCCCCCcccCChhHcccccCChhHHHHHHHHHHHHHHHHHHHHHhccCCChhhcCcCCChHHHHHHHHHHhc Confidence 99999988777777788899988898766666888899999999999999988889999999999999999999999999 Q sp|Q9BYF1|ACE2 561 GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 561 gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) |.+.||.-.++.+.|....+..+++.+|+||.+||+.+|++..+||.++|+|++| T Consensus 561 G~s~~~~ell~~~~g~d~~s~~~~~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 615 (615) T 1R42_A 561 GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (615) T ss_dssp TTSSCHHHHHHHHHSSSSCCSHHHHHHHHHHHHHHHHHTSSSCCSCBSSCCTTCC T ss_pred CCCCCHHHHHHHHHCCCCCChHHHHHhHHHHHHHHHHHhcCCCCCCCCCCCCcCC Confidence 9999999999999999889999999999999999999999999999999999985 No 3 >6LZG_A Angiotensin-converting enzyme 2 (E.C.3.4.17.23), Spike; Novel Coronavirus, Spike protein, receptor; HET: NAG; 2.5A {Homo sapiens} Probab=100.00 E-value=5.4e-74 Score=545.88 Aligned_cols=597 Identities=100% Similarity=1.567 Sum_probs=545.8 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ||.++.+..+++.++.....+-...+++.|.++++.+++..+..+.+..+.+.+..+.+.....+.+..+.+-..+-+|+ T Consensus 1 ~~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~ 80 (597) T 6LZG_A 1 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 80 (597) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCCCHHHHHHHH T ss_pred CChHHHHHHHHHHHHHHHHHHHhHHHhHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCChhhcCCHHHHHHHH Confidence 35567788999999999999999999999999999999988888888899999998888877777766666666777788 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 178 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrp 178 (805) .+...+...|+++..++++.+++.+..+|++...|.+++|.+|+.+.+.+..+|+++-|...|.-+|++|++..++.+.+ T Consensus 81 ~~~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~ 160 (597) T 6LZG_A 81 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 160 (597) T ss_dssp HHHCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEECTTCTTCEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH T ss_pred HHHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCceeccCccHHHHHhcCCCHHHHHHHHHHHHHHhcHHhHH Confidence 77777778889988888889999999999999999998889999999999999999999999999999999988889999 Q sp|Q9BYF1|ACE2 179 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 258 (805) Q Consensus 179 lyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp 258 (805) ++.+.|.+++++|+.+.|++|.|||...+++++++++||+..++.+-++..++.|+|+|+.+|+|+|.++...|..-+++ T Consensus 161 ~l~~lv~~r~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~~~~~~~~~~l~~l~~~v~p~~~~~~~~~~~~~~~~~~~~~~~ 240 (597) T 6LZG_A 161 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 240 (597) T ss_dssp HHHHHHHHHHHHHHHTTCSSHHHHHHGGGCBCSCTTTCBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSTTTCCS T ss_pred HHHHHHHHHHHHHHHCCCCCHHHHHHHhhccCCCCCCCCchhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCccCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999877766543445 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) -+..|+|++|.+|+..|+++|....|+.+.+..++++.+..+.+..+++++.++++|-++|+..+...+|+++.+..++. T Consensus 241 ~~~~p~d~~~~~~~~~~~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~k 320 (597) T 6LZG_A 241 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 320 (597) T ss_dssp SSCEETTSSSSSSCSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCS T ss_pred CCCCcHHHcccchhhhhhhhHhccCCCCCCCCCCCcHHHHHcCCCHHHHHHHHHHHHHHcCCccCCcchhhhhccCCCCC Confidence 57899999999999999999999999999888889998888899999999999999999999999999999998888888 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 418 (805) Q Consensus 339 vqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhl 418 (805) ...+.|+|.+|+...++.||++|...+.+|+.+.+||+||..|.+.+..||++++.+++.+|+|+++++|+..+.+|.+| T Consensus 321 ~~~~~c~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~L 400 (597) T 6LZG_A 321 VQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 400 (597) T ss_dssp SSCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTHHHHHHHHHHHHHHSHHHH T ss_pred CCCCccCccHhcCCCCcEEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCCchhcCCCChHHHHHHHHHHHHHhcCHHHH Confidence 78899999999876689999999999999999999999999999999999999988889999999999999999999999 Q sp|Q9BYF1|ACE2 419 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 419 ksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) +.++++....+.+.+..++.++.+++..+..+|+..+++.|+|-+|.|+++.+.+.+.||+...+..|++.|++.++... T Consensus 401 ~~~~l~~~~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~ 480 (597) T 6LZG_A 401 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 480 (597) T ss_dssp HHTTSSCTTCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTCSCGGGHHHHHHHHCCCCCCEECSSCCCTTCC T ss_pred HHcCCCCcccCCChHHHHHHHHHHHHHHHhhchhHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCCcccC Confidence 99998876554455667888999999999999999999999999999999999999999999999999988776667778 Q sp|Q9BYF1|ACE2 499 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKN 578 (805) Q Consensus 499 dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgakn 578 (805) ++++..|+..+..+..|....+..+|+.+.+|+...++||+|.|++.++.++|+++.++|+.|.+.+|.-.++.+.|... T Consensus 481 ~~~~~~H~~~~~~Yy~Y~~~~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~G~s~~~~ell~~~~g~~~ 560 (597) T 6LZG_A 481 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKN 560 (597) T ss_dssp GGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSCSS T ss_pred ChhHccccccChhHHHHHHHHHHHHHHHHHHHHHhccCCChhhCCcCCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCC Confidence 88888887655555888899999999999999988889999999999999999999999999999999999999999988 Q sp|Q9BYF1|ACE2 579 MNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 579 mnvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) .+..++++||+||..||+.+|++..+||.++|.|++| T Consensus 561 ~~~~~l~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 597 (597) T 6LZG_A 561 MNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 597 (597) T ss_dssp CCSHHHHHHHHHHHHHHHHHGGGSCCSCCSSCCTTC- T ss_pred CCcHHHHHhHHHHHHHHHHhhcCCCCCCCCCCCCCCC Confidence 8899999999999999999999999999999999985 No 4 >3D0I_B Crystal structure of spike protein; SARS coronavirus, spike protein, receptor-binding; HET: NAG, NDG; 2.9A {Paguma larvata} Probab=100.00 E-value=1.2e-73 Score=545.19 Aligned_cols=596 Identities=98% Similarity=1.548 Sum_probs=544.0 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) |-++.++.|+++++.....+-...+.+.|.++++.+++..+....+-.+.+.+.++.......|.+..+.+-..+-+|+. T Consensus 2 ~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 81 (597) T 3D0I_B 2 TTEELAKTFLETFNYEAQELSYQSSVASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 81 (597) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCGGGCCCHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHhhCChhhcCCHHHHHHHHH Confidence 33567788999999999999999999999999999999888888888899999888887777777666666667778888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 179 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrpl 179 (805) +...+...|+++...+++.+.+.+..+|++..+|.+++|.+|+.+.+.+..+|.++-|...|..+|++|+...+..+.+. T Consensus 82 l~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~ 161 (597) T 3D0I_B 82 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 161 (597) T ss_dssp HSCCTGGGSCHHHHHHHHHHHHHHHHHHHHCEEEETTEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHTHHHHHHHH T ss_pred HHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCcccccCccHHHHHhcCCCHHHHHHHHHHHHHHhcHHhHHH Confidence 88888888999888888899999999999999998888888998888999999999999999999999998888899999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPI 259 (805) Q Consensus 180 yeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispi 259 (805) +.+.+.+++++|+.+.|++|.+||-.++++++.+++||+..++.+-++..++.|+|+|+.+|+|+|.++...|..-+++- T Consensus 162 l~~lv~lr~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~~~~~~~~~~l~~l~~~i~p~~~~~~~~~~~~~~~~~~~~~~~~ 241 (597) T 3D0I_B 162 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPI 241 (597) T ss_dssp HHHHHHHHHHHHHHTTCSSHHHHHHGGGCBCSSSSSCBCHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHSTTSCCTT T ss_pred HHHHHHHHHHHHHHCCCCCHHHHHHHhcccCCCCCCCCChhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCcccCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999998776664334455 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) ...|+|++|+||+.-|+.+|....|+.+.+..+++..++.+.+...++++.++++|-++|+..+...||+++....++.. T Consensus 242 ~~~p~~~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~K~ 321 (597) T 3D0I_B 242 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 321 (597) T ss_dssp BCEEGGGSSSSSCSCCGGGGGGTCSCTTSCCSCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCSS T ss_pred CCccHHHccccchhhchhhHhhcCCCCCCCCCCCcHHHHHcCCCHHHHHHHHHHHHHHcCCccCCcchHhhhccCCCCCC Confidence 78999999999999999999999999998888999999888899999999999999999999999899999998888888 Q sp|Q9BYF1|ACE2 340 QKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 340 qkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ..+.|+|.+|++..++.||++|...+++|+.|.+||+||+.+.+.+..||++.+..++.+|.|+++++|+..+.+|.+|+ T Consensus 322 ~g~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~l~e~~~~~~~~L~ 401 (597) T 3D0I_B 322 QKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 401 (597) T ss_dssp SCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTHHHHHHHHHHHHHHSHHHHH T ss_pred CCCccCccHhhcCCCcEEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCChhHcCCCChHHHHHHHHHHHHHhcCHHHHH Confidence 88999999999877899999999999999999999999999999998999999888899999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++........+..++.++.+++..+..+|+.++++.|+|.+|.|+++.+.+.+.||+..++..|+..|++.++...+ T Consensus 402 ~~~~~~~~~~~~~~~~~~~l~~~~l~~l~~l~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~y~g~~~~~~~~~~~~~ 481 (597) T 3D0I_B 402 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 481 (597) T ss_dssp HHTSSCSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCTTTTTHHHHHHHHHTSCEECSSCCCTTCCC T ss_pred HcCCCCcccCCChHHHHHHHHHHHHHHHhcchHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCCcccCC Confidence 99988765444455677889999999999999999999999999999998899999999999999998887776667778 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) +++..|+..+..++.|....+..+|+.+.+|+...+.||+|.||+..+.++|+++.++|+.|.+.+|.-.++...|.... T Consensus 482 ~~~~~H~~~~~~Yy~Y~~s~~~a~~i~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~~G~s~~~~ell~~~~g~d~~ 561 (597) T 3D0I_B 482 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 561 (597) T ss_dssp GGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSCSSC T ss_pred hhHccccccChhHHHHHHHHHHHHHHHHHHHHHhcccCChhhcCcCCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCCC Confidence 88888887655558888899999999999999888899999999999999999999999999999999999999999888 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) ++.+++.+|+||..||+.+|++..+||.++|.|++| T Consensus 562 ~~~~~~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 597 (597) T 3D0I_B 562 NVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 597 (597) T ss_dssp CSHHHHHHHHHHHHHHHHHGGGSCCSCBTTCCSSCC T ss_pred CcHHHHHhHHHHHHHHHHhhcCCCCCCCCCCCCCCC Confidence 899999999999999999999999999999999985 No 5 >5AMB_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1), AMYLOID BETA; HYDROLASE, ANGIOTENSIN-CONVERTING ENZYME, METALLOPROTEASE, AMYLOID-BETA; HET: P6G, PG4, FUC, NAG, PEG, BMA; 1.55A {HOMO SAPIENS} Probab=100.00 E-value=1.2e-69 Score=524.17 Aligned_cols=595 Identities=42% Similarity=0.814 Sum_probs=518.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---LQEIQNLTVKLQ 96 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---lqeiqnltvklq 96 (805) .-++.+.+||+.++.+...+-...+++.|.++++.+.+..+....+..+.+.+..+.++.+.... ++.+..-..+-+ T Consensus 12 ~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~ 91 (629) T 5AMB_A 12 ADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRI 91 (629) T ss_dssp SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTGGGCSCHHHHHH T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHhcCCHHHHHH Confidence 34577889999999999999999999999999999999888888888888888887766433211 122233345556 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQL 176 (805) Q Consensus 97 lqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkql 176 (805) |+.+...+...|+++..+++..+.+.|+.+|++...|.++.+..|+.+.+.+..+|+++-|...|.-+|+.|+...+..+ T Consensus 92 l~~l~~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~ 171 (629) T 5AMB_A 92 IGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLPQKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPL 171 (629) T ss_dssp HHHHTCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEEC---CCCEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcccCCCHHHHHHHHHHHHHHHHHHhhccccCCCCCCceeecChhHHHHHHhCCCHHHHHHHHHHHHHHhCccc Confidence 66666666677888887888889999999999999998777778888888999999999999999999999999888999 Q sp|Q9BYF1|ACE2 177 RPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-Y 255 (805) Q Consensus 177 rplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-y 255 (805) ++++.+.|-+++++|+...|++|.+||..+|+. +...+.++..++.|+|+|+.+|+|+|.++...|.. . T Consensus 172 ~~~l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~~~~~l~~l~~~i~~~~~~~~~~~~~~~~~~~g~~~ 241 (629) T 5AMB_A 172 KPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNS----------PTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRY 241 (629) T ss_dssp HHHHHHHHHHHHHHHHTTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTT T ss_pred HHHHHHHHHHHHHHHHHcCCCCHHHHHHHhhCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccc Confidence 999999999999999999999999999887642 34556677888999999999999999987665542 2 Q sp|Q9BYF1|ACE2 256 ISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTD 335 (805) Q Consensus 256 ispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltd 335 (805) +++-+.+|+|++|++|+..|+++|.+++|+.+....+|++.++.+.+....+++.++++|.++|++.++..||++++... T Consensus 242 ~~~~~~ip~dll~~~~~~~~~~~~~~~~p~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~~~~~~ 321 (629) T 5AMB_A 242 INLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEK 321 (629) T ss_dssp CCTTSCEETTSSSSTTSCCCGGGHHHHCSCTTSCCCCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSC T ss_pred cCCCCCCCHHHccChhhhhhhhhhcccccCCCCCCCCCcHHHHhcCCCHHHHHHHHHHHHHhCCCCCCChhHhhcccccC Confidence 33445679999999999999999999999988888889999999888899999999999999999999999999999888 Q sp|Q9BYF1|ACE2 336 PGNVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAAT 414 (805) Q Consensus 336 pgnvqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaat 414 (805) |+.....+|||.+|++.. ++.||++|...+++|+.|.+|||||..|.+.+..||++.+.+++.+|||+++++|+..+.+ T Consensus 322 ~~k~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~ 401 (629) T 5AMB_A 322 PADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVST 401 (629) T ss_dssp CTTCCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHTS T ss_pred CCCCCccccccchhhccCCCCeEEEecCCCCHHHHHHHHHHHHHHHHHHHcCCCCHHHcCCCCHHHHHHHHHHHHHHhcC Confidence 887777899999999985 7899999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 415 PKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHD 494 (805) Q Consensus 415 pkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphd 494 (805) |.+|+.++++... +...+..++.++++++..+..+|+.++++.|+|.+|.|+++.+++.+.||+..++..|+..|.+.+ T Consensus 402 ~~~L~~~~~~~~~-~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~ 480 (629) T 5AMB_A 402 PEHLHKIGLLDRV-TNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRN 480 (629) T ss_dssp HHHHHHTTSCCCC-CCSHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHCCCCCCEECSSCCC T ss_pred HHHHHHcCCCCCC-CCCcHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHhhCCCCChhhHHHHHHHHHHHhCCCCCCCCCC Confidence 9999999987543 223345678899999999999999999999999999999999999999999999999987766667 Q sp|Q9BYF1|ACE2 495 ETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVV 574 (805) Q Consensus 495 etycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvv 574 (805) +...||++..|+..+..++.|....+.++|+-+.+|+...++||||+||+..+.++|+++.++|+.|.+.+|.-.++.+. T Consensus 481 ~~~~~~~~~~H~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~pl~~~~~~~~~~~g~~~~~~L~~G~s~~~~ell~~~~ 560 (629) T 5AMB_A 481 ETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMV 560 (629) T ss_dssp TTCCGGGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHHHTTSSCHHHHHHHHH T ss_pred cccCCcCcccccCCChhHHHHHHHHHHHHHHHHHHHHHcCCCCCcccCCccCCHHHHHHHHHHHhcCCCCcHHHHHHHHh Confidence 78889999999876556889999999999999999998889999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 575 GAKNMNVRPLLNYFEPLFTWLKDQNK--NSFVGWST-DWSPYADQSIKVRISLK 625 (805) Q Consensus 575 gaknmnvrpllnyfeplftwlkdqnk--nsfvgwst-dwspyadqsikvrislk 625 (805) |....+..+++.+|+||..||+.+|+ +.-+||.. +|.|++..+++++|++- T Consensus 561 G~d~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~~~~~~~~~~~~~~~~ 614 (629) T 5AMB_A 561 GLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLV 614 (629) T ss_dssp SCSSCCSHHHHHHHHHHHHHHHHHHHHHTCCSSCSCTTCCCCCCTTCSCC---- T ss_pred CCCCCChHHHHHHHHHHHHHHHHHHHhcCcccCCcccCCCCCCCCCCCCCCCCC Confidence 99889999999999999999999999 56699996 99999999999999983 No 6 >6H5W_A Angiotensin-converting enzyme (E.C.3.2.1.-,3.4.15.1); Angiotensin-1 converting enzyme, ACE inhibitor; HET: BO3, CSO, FUC, FT8, P6G, EDO, BMA, IMD, NAG; 1.37A {Homo sapiens} Probab=100.00 E-value=4.4e-61 Score=455.72 Aligned_cols=579 Identities=43% Similarity=0.858 Sum_probs=503.4 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +..+..||+.++.....+-...+++.|.++++++++.++....+-.+.+.+..+..+.+..|..+.+.+-.++-.++.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (591) T 6H5W_A 5 EAEASKFVEEYDRTSQVVWNEYAGANWNYNTNITTETSKILLQKNMQIAQHTLKYGTQARKFDVNQLQNTTIKRIIKKVQ 84 (591) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCCCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHhhHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcccCCCHHHHHHHHHHH Confidence 55678899999999999999999999999999999999999989999999999888877766645555555666666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYE 181 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrplye 181 (805) ..+...|+++....+..+...+..+|++.++|.++ .+|+.+.+.+..+|+++-|...|.-+|+.|+...+..++|.+. T Consensus 85 ~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~--g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l~ 162 (591) T 6H5W_A 85 DLERAALPAQELEEYNKILLDMETTYSVATVCHPQ--GSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYP 162 (591) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEECTT--SCEEECCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHTTTHH T ss_pred hhhhccCCHHHHHHHHHHHHHHHhhhccceecCCC--CceecCChhHHHHHhhCCCHHHHHHHHHHHHHHhhHHhHHHHH Confidence 66666778876667777788888999999999874 4677788899999999999999999999999887889999999 Q sp|Q9BYF1|ACE2 182 EYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPIG 260 (805) Q Consensus 182 eyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispig 260 (805) +.+-+++++|+...|++|.+||..+|+. +.+.+.++..++.++|+|+.+|+|+|.|+...+.. -+++-+ T Consensus 163 ~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 232 (591) T 6H5W_A 163 KYVELINQAARLNGYVDAGDSWRSMYET----------PSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEG 232 (591) T ss_dssp HHHHHHHHHHHHTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHCGGGCCTTS T ss_pred HHHHHHHHHHHHCCCCCHHHHHHhccCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccCCCCC Confidence 9999999999999999999999887732 34557788889999999999999999987544432 244557 Q sp|Q9BYF1|ACE2 261 CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ 340 (805) Q Consensus 261 clpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvq 340 (805) -+|+|++|.+|+.-|+++|.++.|+...+..++++++..+.+...++++.++++|.+.|+..|..+||+++....|+... T Consensus 233 ~~p~~~~~~~~~~~~~~~~~~~~p~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~~~~~~~~k~~ 312 (591) T 6H5W_A 233 PIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKSMLEKPTDGR 312 (591) T ss_dssp CEETTSSSSTTSSCCGGGHHHHCSCTTSCCCCHHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSSC T ss_pred CCcHHHchhhhhHhhHhhhhccCCCCCCCCCCcHHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHHhhccccCCCCCC Confidence 88999999999999999999999998888888888877777888999999999999999988889999998877777655 Q sp|Q9BYF1|ACE2 341 KAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 341 kavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ..+|||.++++.. ++.||++|...+.+++.|.+||+||..|.+.+..||++++.++.-+|+|+++++|+..+.+|.+|+ T Consensus 313 ~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~l~ 392 (591) T 6H5W_A 313 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLH 392 (591) T ss_dssp CCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHHH T ss_pred cceecceeeeCcCCCceEEEecCCCCHHHHHHHHHHHHHHHHHHHhcCCCHHHccCCChHHHHHHHHHHHHHhcCHHHHH Confidence 6799999999875 689999999999999999999999999999999999999888999999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++... ..+.+..++.++.+++..+..+|+.++++.|+|-++.|.++.+++-+.||+...+..|+..|.+......| T Consensus 393 ~~~~~~~~-~~~~~~~~~~l~~~~~~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~~ 471 (591) T 6H5W_A 393 SLNLLSSE-GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFD 471 (591) T ss_dssp HTTSSCCC-CSCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTSSCTTTHHHHHHHHCCCCCCEECSSCCCTTCCG T ss_pred hcCCCCCC-CCChHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHhCCCCCHHhHHHHHHHHHHHHcCCCCCCCCCcccCC Confidence 99987653 23334467788899999999999999999999999999888889999999999999898766555566778 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) |++..|......+..|....+..+|+.+.+|+...|+||+|.|++..+.++|+++-++|+.|.+.+|.-.++...|..-. T Consensus 472 ~~~~~H~~~~~y~y~Y~~~~~~a~ql~~~~~~~~~~~~~l~~~~~~~~~~~g~~~~~~l~~G~s~~~~ell~~~~g~d~~ 551 (591) T 6H5W_A 472 PGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQM 551 (591) T ss_dssp GGGSTTTTTTCCSHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSSCSC T ss_pred CcccccCCCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCcccCCccCCHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCCC Confidence 88888888666778888888999999999999888899999999998899999999999999999999999999998878 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKN--SFVGWST-DWSPY 613 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnkn--sfvgwst-dwspy 613 (805) +..+++.+|+|+..||+.+|+. --+||.. .|.|- T Consensus 552 ~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~~~~ 588 (591) T 6H5W_A 552 SASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPN 588 (591) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHHTCCCSCSSTTCCCC T ss_pred ChHHHHHhHHHHHHHHHHHHHhhCCccCCCccCCCCC Confidence 8999999999999999999875 4599987 67664 No 7 >6S1Y_A Angiotensin-converting enzyme (E.C.3.4.-.-); metalloprotease, mosquito control, insecticide design; HET: PEG, EDO, NAG, BMA, KSN; 2.2A {Anopheles gambiae} Probab=100.00 E-value=4.6e-59 Score=450.26 Aligned_cols=579 Identities=37% Similarity=0.727 Sum_probs=484.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 21 IEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQAL 100 (805) Q Consensus 21 ieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqal 100 (805) -++++.++++.++.....+-...+++.|.++++.+.+..+....+-.+.+.+..+..+...-+....+..-..+-+++.+ T Consensus 11 ~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~l~~~ 90 (621) T 6S1Y_A 11 SETEISQIVEWIEQRYQQTKAHQTLAAWEYGSNLTEFNLSKKTKAAADFAEVAKAVAEELQQFKTDQLTNATLKRRIKKL 90 (621) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCSSSCCCHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCHHHHHHHHHH Confidence 34677889999999999999999999999999999988887666777777777654432111111122233455566666 Q sp|Q9BYF1|ACE2 101 QQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNP-QECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 179 (805) Q Consensus 101 qqngssvlsedkskrlntilntmstiystgkvcnpdnp-qeclllepglneimansldynerlwaweswrsevgkqlrpl 179 (805) ...+...|+++..+++..++..++.+|++..+|.++.+ .+++.+.+.+..+|+++-|...|--+|++|++..+..+.++ T Consensus 91 ~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~ 170 (621) T 6S1Y_A 91 AKLGYAALPADQFKELLGAIASMESNYAKAKFCAYGDATKCDLSLDPELTEIFANHREPEELKYYWVQWYNATGAPVRES 170 (621) T ss_dssp TCCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCBTTBTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHH T ss_pred HHhccccCCHHHHHHHHHHHHHHHHHHHhhccccCCCCCCCcccCChHHHHHHHhCCCHHHHHHHHHHHHHhcChhHHHH Confidence 66666678888777788888899999999888765422 23455668899999999999999999999999888899999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISP 258 (805) Q Consensus 180 yeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yisp 258 (805) +.+.|-+++++|+...|.+|.+|+..++++ +.+.+-++..++.++|+++.+++|++.++...|.. -+++ T Consensus 171 l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~v~~~~~~~~~~~~~~~~~~~g~~~~~~ 240 (621) T 6S1Y_A 171 FQKYVELNRQAALRNNFSSGAAVWLNEYDD----------STFEQQVDDVIEQIRPLYEQLHAYVRYKLRQKYGDKLVSP 240 (621) T ss_dssp HHHHHHHHHHHHHHTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCS T ss_pred HHHHHHHHHHHHHHCCCCCHHHHHHhcCCc----------hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCCCCC Confidence 999999999999999999999999876642 34556677788899999999999999987554432 3456 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) -+-+|+|+||.+|+.-|..+|.+..|+.+....++++.++.+-+..+++++.++++|-++|+..++..||++++...|.. T Consensus 241 ~~~ip~~~l~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~v~~~~~~ 320 (621) T 6S1Y_A 241 TGPIPMHLLGNLWAQTWDNIADFTTPFPEKKLLDVTDEMIRQGYTPIKMFQMGDDFFTSLNMTKLPQTFWDKSILEKPTD 320 (621) T ss_dssp SSCEEGGGSSSTTCSCCGGGTTTTCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSS T ss_pred CCCCcHHHhhcchhccchhhhhhcCCCCCcccCCCcHHHHHCCCCHHHHHHHHHHHHHHCCCCCCChhHhhhhhccCCCC Confidence 78999999999999999999999999876666778888988888899999999999999999999999999999875432 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 339 vqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) -....|||..+.+.. +|.||++|+..+.+|+.|.+||+||..|.+.+..||++.+.+++.+|+|+++++|+..+.+|.+ T Consensus 321 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~~~~~~~~~p~~~~~~~~~~~~E~~s~~~e~~~~~~~~ 400 (621) T 6S1Y_A 321 GRDLVCHASAWDFFAIDDVRIKQCTRVNMREFFVVHHELGHIQYYLQYQHQPVEFRGGANPGFHEAVGDVLSLSVSTPKH 400 (621) T ss_dssp CCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCCCchhhhhccCCCCEEEEeCCCCCHHHHHHHHHHHHHHHHHHHhccCCchhcCCCChHHHHHHHHHHHHHhcCHHH Confidence 222468888888875 6999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++.. .....+..++.++++++..+..+|+..++.+|++.++.|.+..+.+-+.||+...+..|+..|.+.++.. T Consensus 401 L~~~~l~~~-~~~~~~~~~~~l~~~~l~~l~~~~~~~~~d~fe~~l~~~~~~~~~l~~~~~~l~~~y~g~~~~~~~~~~~ 479 (621) T 6S1Y_A 401 LKKVGLLKD-YEEDEQVKINQFYRAGVTKLVFLPFAYTLDKYRWGVFRGDIKPREYNCKFWEMRSRYSGVEPPVVRTEQD 479 (621) T ss_dssp HHHTTSSCC-CCCCHHHHHHHHHHHCCCCCTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHHHHHHCEECSSCEETTC T ss_pred HHHcCCCCC-CCCCHHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCChHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 999998753 3333345667888899999999999889999999999998877888999999999999976665566677 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .||+...|+.....++.|....+..+|+-+.+|+...+ ++|||.||+..+.++|.++.++|+.|.+.+|.-.++ T Consensus 480 ~~~~~~~H~~~~~~~~~Y~~~~~~a~qi~~~~~~~~~~~~~~~~~~~l~~c~~~~~~~~~~~~~~~l~~G~s~~~~ell~ 559 (621) T 6S1Y_A 480 FDPPAKYHVSADVEYLRYFVSYVIQFQFHRAACALAGEYVKGDPEKTLNNCDIYQSTAAGNQLKEMLALGSSKPWPDAME 559 (621) T ss_dssp CCGGGSHHHHTTCCSHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCTTSCCCTTCHHHHHHHHHHHHTTTSSCHHHHHH T ss_pred CCcchheeecCCchHHHHHHHHHHHHHHHHHHHHHhCCccCCCCCCCcccCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 88888888875556888999999999999999987643 579999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKN--SFVGWSTDW 610 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkn--sfvgwstdw 610 (805) ...|....+..+++.||+|+.+||+.+|++ --+||..+| T Consensus 560 ~~~G~d~~s~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~ 600 (621) T 6S1Y_A 560 VLTGERKMSADAILEYFDPLYQWLLEENKRLGAHVGWTDSQ 600 (621) T ss_dssp HHHSCCSCCTHHHHHHTHHHHHHHHHHHHHHTCCCSCCCCC T ss_pred HHHCCCCCChHHHHHHHHHHHHHHHHHHHHhCCCCCCCccc Confidence 999988889999999999999999988875 459999775 No 8 >4CA5_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.2.1.-, 3.4.15.1); HYDROLASE, ZINC METALLOPEPTIDASE, INHIBITOR BINDING; HET: FUC, 3EF, ACT, NAG; 1.85A {HOMO SAPIENS} Probab=100.00 E-value=3.9e-58 Score=435.55 Aligned_cols=578 Identities=43% Similarity=0.863 Sum_probs=497.1 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +..++.|++.++.+...+-...+++.|.++++.+++..+....+-.+.+.++.+..++...|..+.+.+-..+-+++.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (589) T 4CA5_A 5 EAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQ 84 (589) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCGGGCCCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcChhhCCCHHHHHHHHHHH Confidence 56778999999999999999999999999999999999988888888888888777766655333444445566666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYE 181 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrplye 181 (805) ..+...|+++.-+++..+...+..+|++..+|.++ .+|+.+.+.+..+|.++-|...|--+|++|+...+..+.+.+. T Consensus 85 ~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~--g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l~ 162 (589) T 4CA5_A 85 DLERAALPAQELEEYNKILLDMETTYSVATVCHPN--GSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYP 162 (589) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCEECTT--SCEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHTTTHH T ss_pred hhhhccCCHHHHHHHHHHHHHHHhhhccceecCCC--CCeecCChhHHHHHhhCCCHHHHHHHHHHHHHHhhHHHHHHHH Confidence 66667888887777788888899999998888775 3567777889999999999999999999999988889999999 Q sp|Q9BYF1|ACE2 182 EYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPIG 260 (805) Q Consensus 182 eyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispig 260 (805) +.+-+++++|+...|.+|.+||..+|+. +.+.+.++..++.++|+|+.+|+|++.++...|.. -++.-+ T Consensus 163 ~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~v~p~~~~l~~~~~~~~~~~~g~~~~~~~~ 232 (589) T 4CA5_A 163 KYVELINQAARLNGYVDAGDSWRSMYET----------PSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEG 232 (589) T ss_dssp HHHHHHHHHHHHTTCSSHHHHHHGGGCC----------TTHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHCTTTCCTTS T ss_pred HHHHHHHHHHHHcCCCCHHHHHHHccCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccCCCCC Confidence 9999999999999999999999887732 33457788889999999999999999987554431 133446 Q sp|Q9BYF1|ACE2 261 CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ 340 (805) Q Consensus 261 clpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvq 340 (805) -.|+|++|.+|+.-|+++|....||......++++.+..+.+...++++.++.+|-++|+..+...+|+++....++.-. T Consensus 233 ~~p~~~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~d~~~r~~K~~ 312 (589) T 4CA5_A 233 PIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGR 312 (589) T ss_dssp CEETTSSSSTTSSCCGGGHHHHCSCTTSCCCCHHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSSC T ss_pred CCcHHHhhhhhhhccccchhhcCCCCCCCCCCcHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHhchhhccCCCCCC Confidence 78999999999999999999999998888888888888888888999999999999999877888899998887777665 Q sp|Q9BYF1|ACE2 341 KAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 341 kavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ...|||..+++.. ++.||++|...+.+++.|.+||+||..+.+.+..+|++.+.+++-+|+|+++++|+..+.+|.+|+ T Consensus 313 ~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~l~ 392 (589) T 4CA5_A 313 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLH 392 (589) T ss_dssp CCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHSTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHHH T ss_pred CceecceeEeCcCCCcEEEEEcCCCCHHHHHHHHHHHHHHHHHHHcCCCCHHHccCCChHHHHHHHHHHHHHhcCHHHHH Confidence 6789999998864 689999999999999999999999999999988999999888999999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++... +.+.+..++.++.+++..+..+|+.++++.|.+.++.|.+..+.+-+-||+...+.-|+..|.+......| T Consensus 393 ~~~~~~~~-~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~~ 471 (589) T 4CA5_A 393 SLNLLSSE-GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFD 471 (589) T ss_dssp HTTSSCCC-CSCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTSSCTTTHHHHHHHHCCCCCCEECSSCCCTTCCG T ss_pred HcCCCCCC-CCChHHHHHHHHHHHHHHHhhchHHHHHHHHHHHHhCCCCChHhHHHHHHHHHHHHcCCCCCCCCChhhCC Confidence 99987653 22334456788999999999999999999999999999888888999999988888887655444455677 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) |++..|......+..|....+..+|+-+.+|+...+.||+|.|++..+.++|.++.++|+.|.+.||.-.++.+.|.... T Consensus 472 ~~~~~H~~~~~y~y~Y~~~~~~a~~l~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~~G~~~~~~ell~~~~g~d~~ 551 (589) T 4CA5_A 472 PGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNM 551 (589) T ss_dssp GGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHHTTTSSCHHHHHHHHHSSCSC T ss_pred ccccccCCCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCCC Confidence 77888887666778888888999999999999888889999999998899999999999999999999999999998888 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKNS--FVGWST-DWSP 612 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnkns--fvgwst-dwsp 612 (805) ++.+++.+|+||..||+.+|+.. -+||.. .|.| T Consensus 552 ~~~~~~~~~~~l~~~l~~~~~~~~~~~g~~~~~~~~ 587 (589) T 4CA5_A 552 SASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTP 587 (589) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHTTCCCSCSSTTCCC T ss_pred ChHHHHHhHHHHHHHHHHHHHhhCCccCCcccCCCC Confidence 99999999999999999998754 489988 7876 No 9 >5A2R_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1); HYDROLASE, ANGIOTENSIN CONVERTING ENZYME, DROSOPHILA; HET: NAG; 1.85A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=2.8e-56 Score=425.09 Aligned_cols=579 Identities=37% Similarity=0.721 Sum_probs=483.2 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++...++|++++.....+-.....+.|.++++.+++..+..+.+..+.+.+.++.......|.++....-..+-+|+.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (598) T 5A2R_A 5 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 84 (598) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHGGGSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhcHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhhCCCHHHHHHHHHHH Confidence 35677899999999999999999999999999999988877777888888887766655444422222233455566666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..++.+|++...|..+. ...++.+.+.+..+|+++-|...|--+|+.|+...+..+.+.+ T Consensus 85 ~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l 164 (598) T 5A2R_A 85 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 164 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCCSSCTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhcccCCCHHHHHHHHHHHHHHHHHHhccccCCCCCCCCCcccCCHHHHHHHHcCCCHHHHHHHHHHHHHHccHHHHHHH Confidence 677778888888888888889999999887776432 1245566788999999999999999999999998888999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|++|.+|+..+++ ...+.+-++..++.|+|+|+.+|+|++.++...|.. -++.- T Consensus 165 ~~l~~~r~~~A~~~Gy~s~~~~~l~~~~----------~~~v~~~l~~l~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 234 (598) T 5A2R_A 165 ERYVELNTKAAKLNNFTSGAEAWLDEYE----------DDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 234 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGGC----------CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhccC----------CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCccccCCC Confidence 9999999999999999999999976543 223345566677889999999999999987554321 12334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+.+++..++++.+....+....+++-++++|-++|+..+..++|++++...|..- T Consensus 235 ~~~p~~l~g~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~~ 314 (598) T 5A2R_A 235 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDG 314 (598) T ss_dssp SCEEGGGSSSTTCSCCGGGHHHHCSCTTSCCCCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSC T ss_pred CCCCHHHhhchhhhhhHhhhhhcCCCCCCCCCCchHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChhhhhhhhccCCCCC Confidence 56799999999999999999999999888777888888777788899999999999999999988999999987644321 Q sp|Q9BYF1|ACE2 340 QKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 418 (805) Q Consensus 340 qkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhl 418 (805) ....|||.++.+.. ++.||++|...+.+|+.|.+||+||..+.+.+..||++.+++.+.+|+|+++++|++.+.+|.+| T Consensus 315 k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~L 394 (598) T 5A2R_A 315 RDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHL 394 (598) T ss_dssp CCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHH T ss_pred CCCccccceEeCcCCCCeEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChhHccCCChHHHHHHHHHHHHHhcCHHHH Confidence 11358888888774 68999999999999999999999999999999889999999999999999999999999999999 Q sp|Q9BYF1|ACE2 419 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 419 ksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) +.++++. ....+.+..++.++.+++..+..+|+......|++-++.|++....+-+.||+...+.-|++.|.+.+...+ T Consensus 395 ~~~~~~~-~~~~~~~~~~~~l~~~~l~~l~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~ 473 (598) T 5A2R_A 395 EKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDF 473 (598) T ss_dssp HHTTSSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHHHHHHCEECSSCEETTCC T ss_pred HHcCCCC-ccCCChHHHHHHHHHHHHHHhhhcHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhhC Confidence 9999874 333444567788899999999999998888999999999988778899999999999989876655555557 Q sp|Q9BYF1|ACE2 499 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572 (805) Q Consensus 499 dpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlalen 572 (805) ++++..|+..+..++.|....+..+|+-+.+|+...+ .||+|.||...+.++|+++.++|+.|.+.||.-.++. T Consensus 474 ~~~~~~hi~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~G~s~~~~e~~~~ 553 (598) T 5A2R_A 474 DAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEA 553 (598) T ss_dssp CGGGSHHHHTTCCCHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHH T ss_pred CCccceeecCCchHHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHH Confidence 7888888775556788888889999999998886544 6799999999889999999999999999999999999 Q sp|Q9BYF1|ACE2 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNSF--VGWSTDWS 611 (805) Q Consensus 573 vvgaknmnvrpllnyfeplftwlkdqnknsf--vgwstdws 611 (805) ..|..-.+..+++.+|.|+-.||+.+|+..- +||..+|. T Consensus 554 ~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~w~~~~~ 594 (598) T 5A2R_A 554 FNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 594 (598) T ss_dssp HHSCCSCCSHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCSC T ss_pred HhCCCCCChHHHHHHHHHHHHHHHHhHHhcCCcCCccCCCc Confidence 9999878999999999999999999987665 99999873 No 10 >4ASR_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1), BRADYKININ; HYDROLASE, ZINC METALLOPROTEASE, SUBSTRATE RECOGNITION; HET: MAN, NAG, FLC, BMA; 1.9A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=2.9e-56 Score=426.35 Aligned_cols=578 Identities=37% Similarity=0.724 Sum_probs=486.1 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +.+...||..++.....+-....++.|.++++.+++..+..+.+..+.+.+..+..+.+..|.++...+-..+-+|+.+. T Consensus 6 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 85 (598) T 4ASR_A 6 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 85 (598) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHGGGSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhcCCCHHHHHHHHHHH Confidence 46678899999999999999999999999999999988888788888888888777666555533333334555666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..+..+|++...|.... ..+++.+.|.+..+|.++-|...|--+|++|++..+..+.+++ T Consensus 86 ~~~~~~L~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l 165 (598) T 4ASR_A 86 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 165 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCCSSCTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhccccCCHHHHHHHHHHHHHHHHHhhccccCCCCCCCCccccCCHHHHHHHHcCCCHHHHHHHHHHHHHHhcHHHHHHH Confidence 666678888888888888899999999887776432 1255566788999999999999999999999998888999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|.+|.+|+..++ +...+.+-++..++.++|+++.+|+|+|.++...|.. .+++- T Consensus 166 ~~lv~~r~~~A~~~Gy~s~~~~~l~~~----------~~~~v~~~l~~l~~~i~~~~~~l~~~~~~~~~~~~~~~~~~~~ 235 (598) T 4ASR_A 166 ERYVELNTKAAKLNNFTSGAEAWLDEY----------EDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 235 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGG----------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhcc----------CCccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccCCC Confidence 999999999999999999999997654 2334445666778889999999999999987554432 13334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+...+..++++.++.+.+...++|+-++++|-++|+..+..+||++++...+.. T Consensus 236 ~~~p~~l~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~- 314 (598) T 4ASR_A 236 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTD- 314 (598) T ss_dssp SCEEGGGSSSTTSSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSS- T ss_pred CCCcHHHccccchhcchhhhhhcCCCCCCCCCCccHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHhhhhhccCCCC- Confidence 6689999999999999999999999987776677777878888889999999999999999988889999998765432 Q sp|Q9BYF1|ACE2 340 QK-AVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 340 qk-avchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) .| ..|||.++++.. ++.||++|+..+.+|+.|.+||+||..+.+.+..+|++.+.+.+.+|+|+++++|++.+.+|.+ T Consensus 315 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~d~~E~~s~~~e~~~~~~~~ 394 (598) T 4ASR_A 315 GRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKH 394 (598) T ss_dssp SCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGSSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCcccchhhhccCCCCEEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChHHccCCChHHHHHHHHHHHHHhcCHHH Confidence 22 368888888875 5899999999999999999999999999999988999999889999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++. ..+...+..++.++++++..+..+|+..+...|++-++.|++..+.+.+.||+...+..|+..|.+.++.. T Consensus 395 L~~~~~~~-~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~l~~~~~g~~~~~~~~~~~ 473 (598) T 4ASR_A 395 LEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKD 473 (598) T ss_dssp HHHTTSSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHCCCCCCEECSSCEETTC T ss_pred HHHcCCCC-ccCCChHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 99999864 33334455678888999999999999888899999999998877889999999999998987665555555 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .+|.+..|+..+..+..|....+..+|+-+.+|+.+.+ +||+|.|+...+.++|.++-++|..|.+.||.-.++ T Consensus 474 ~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~l~~G~s~~~~el~~ 553 (598) T 4ASR_A 474 FDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALE 553 (598) T ss_dssp CCGGGSHHHHTTCCSHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHH T ss_pred CCCccceeecCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 56777778765555788888888999999999887554 689999999988999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWS 611 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkns--fvgwstdws 611 (805) ...|..-.+..+++.+|+|+-.||+.+|+.. -+||.++|- T Consensus 554 ~~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~ 595 (598) T 4ASR_A 554 AFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 595 (598) T ss_dssp HHHSCCSCCSHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCCS T ss_pred HHhCCCCCChHHHHHHHHHHHHHHHHhhhhcCccccccCCCc Confidence 9999988899999999999999999988755 499999884 No 11 >4CA7_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1); HYDROLASE, ZINC METALLOPEPTIDASE, INHIBITOR BINDING; HET: MAN, NAG, 3EF, BMA; 1.82A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=3.2e-56 Score=426.00 Aligned_cols=578 Identities=37% Similarity=0.724 Sum_probs=485.3 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +.+...||..++.....+-....++.|.++++.+++..+..+.+..+.+.+..+..+.+..|.++...+-..+-+|+.+. T Consensus 6 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 85 (598) T 4CA7_A 6 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 85 (598) T ss_dssp GC-CHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhcCCCHHHHHHHHHHH Confidence 46678899999999999999999999999999999988888788888888888777666555533333334555666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..+..+|++...|.... ..+++.+.|.+..+|.++-|...|--+|++|++..+..+.+++ T Consensus 86 ~~~~~~L~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~~~~~R~~~~~~~~~~~~~~~~~~l 165 (598) T 4CA7_A 86 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 165 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCEECCSSCTTCCCEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhccccCCHHHHHHHHHHHHHHHHHhhccccCCCCCCCCccccCCHHHHHHHHcCCCHHHHHHHHHHHHHHhcHHHHHHH Confidence 666678888888888888899999999887776432 1255566788999999999999999999999988778899999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|.+|.+|+..++ +...+.+-++..++.++|+++.+|+|+|.++...|.. .+++- T Consensus 166 ~~lv~~r~~~A~~~Gy~s~~~~~l~~~----------~~~~v~~~l~~l~~~i~~~~~~l~~~~~~~~~~~~~~~~~~~~ 235 (598) T 4CA7_A 166 ERYVELNTKAAKLNNFTSGAEAWLDEY----------EDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 235 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGG----------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhcc----------CCccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccCCC Confidence 999999999999999999999997654 2334445666778889999999999999987554432 13334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+...+..++++.++.+.+...++|+-++++|-++|+..+..+||++++...+.. T Consensus 236 ~~~p~~l~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~- 314 (598) T 4CA7_A 236 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTD- 314 (598) T ss_dssp SCEEGGGSSSTTCSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCS- T ss_pred CCCcHHHccccchhcchhhhhhcCCCCCCCCCCccHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHhhhhhccCCCC- Confidence 6689999999999999999999999987776677777878888889999999999999999988889999998765432 Q sp|Q9BYF1|ACE2 340 QK-AVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 340 qk-avchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) .| ..|||.++++.. ++.||++|+..+.+|+.|.+||+||..+.+.+..+|++.+.+.+.+|+|+++++|++.+.+|.+ T Consensus 315 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~d~~E~~s~~~e~~~~~~~~ 394 (598) T 4CA7_A 315 GRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKH 394 (598) T ss_dssp SCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCcccchhhhccCCCCEEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChHHccCCChHHHHHHHHHHHHHhcCHHH Confidence 22 368888888875 5899999999999999999999999999999988999999889999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++. ..+...+..++.++++++..+..+|+..+...|++-++.|++..+.+.+.||+...+..|+..|.+.++.. T Consensus 395 L~~~~~~~-~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~l~~~~~g~~~~~~~~~~~ 473 (598) T 4CA7_A 395 LEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKD 473 (598) T ss_dssp HHHTTCSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHCCCCCCEECSSCEETTC T ss_pred HHHcCCCC-ccCCChHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 99999864 33334455678888999999999999888899999999998877889999999999998987665555555 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .+|.+..|+..+..+..|....+..+|+-+.+|+.+.+ +||+|.|+...+.++|.++-++|..|.+.||.-.++ T Consensus 474 ~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~l~~G~s~~~~el~~ 553 (598) T 4CA7_A 474 FDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALE 553 (598) T ss_dssp CCGGGSHHHHTTCCCHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHH T ss_pred CCCccceeecCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 56777778765555788888888999999999887554 689999999988999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWS 611 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkns--fvgwstdws 611 (805) ...|..-.+..+++.+|+|+-.||+.+|+.. -+||.++|- T Consensus 554 ~~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~ 595 (598) T 4CA7_A 554 AFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 595 (598) T ss_dssp HHHSCCSCCTHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCCS T ss_pred HHhCCCCCChHHHHHHHHHHHHHHHHhhhhcCccccccCCCc Confidence 9999988899999999999999999988755 499999884 No 12 >2C6F_A ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM (E.C.3.4.15.1); HYDROLASE, ANGIOTENSIN-I CONVERTING ENZYME, N; HET: ACT, GOL, NAG; 3.01A {HOMO SAPIENS} Probab=100.00 E-value=2.3e-52 Score=400.71 Aligned_cols=579 Identities=43% Similarity=0.828 Sum_probs=477.2 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-P--LQEIQNLTVKLQLQ 98 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-p--lqeiqnltvklqlq 98 (805) +++...|+++++.....+--..+.+.|.++++++++..+....+..+.+.|..+.+....-. . +++...-..+-.|+ T Consensus 14 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~l~~~~~~l~~~~~~~~~~~~~~~~l~ 93 (612) T 2C6F_A 14 EAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIG 93 (612) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTSCSCHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchHhhCCCHHHHHHHH Confidence 46677899999999999999999999999999998877666666666666655444321110 0 11111112233344 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 178 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrp 178 (805) .+...+...|+++..+++..+...++.+|++-.+|..+.+.+|+.+.+.+..+|.++-|...|--+|++|+...+..+.+ T Consensus 94 ~l~~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~ 173 (612) T 2C6F_A 94 AVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKP 173 (612) T ss_dssp HHSCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEECCSSCCCCCEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhhcccCCHHHHHHHHHHHHHHHHHHHhccccCCCCCCCcccCChhHHHHHhhCCCHHHHHHHHHHHHHHhCcccHH Confidence 45455556788887777888888999999999988777666788888899999999999999999999999877788999 Q sp|Q9BYF1|ACE2 179 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YIS 257 (805) Q Consensus 179 lyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yis 257 (805) ++.+.+-+++++|+...|++|.+|+..++.. ....+-++...+.++|++..+|+|++.++...+-. .++ T Consensus 174 ~l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~g~~~~~ 243 (612) T 2C6F_A 174 LYEDFTALSNEAYKQDGFTDTGAYWRSWYNS----------PTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYIN 243 (612) T ss_dssp HHHHHHHHHHHHHHTTTCSSHHHHHHGGGCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTCC T ss_pred HHHHHHHHHHHHHHHcCCCCHHHHHHHhhCC----------CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccC Confidence 9999999999999999999999999776542 23345566777888999999999999987554321 233 Q sp|Q9BYF1|ACE2 258 PIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPG 337 (805) Q Consensus 258 pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpg 337 (805) .-+-+|.|++|++|+..|+.+|...+|+.++...++++++....+...++++.++++|-++|+..+...+|+++....|| T Consensus 244 ~~~~lp~d~~~~~~~~~~~~~~~~~~p~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~ 323 (612) T 2C6F_A 244 LRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPA 323 (612) T ss_dssp TTSCEETTSSSSTTCSCCGGGHHHHCSSCSSCCSCTHHHHHHHTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCS T ss_pred CCCCCcHHHccCcchhcchhhhhhhCCCCCCCCCCCcHHHHhCCCCHHHHHHHHHHHHHhcCCCCCChhhhccccccCCC Confidence 34456999999999999999999999998777677778877777888899999999999999998888999999877777 Q sp|Q9BYF1|ACE2 338 NVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPK 416 (805) Q Consensus 338 nvqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpk 416 (805) .-....||+.++++.. ++.||++|...+.+|+.|.+||+||..+.+.+..+|++.++.++.+|+|+++++|+..+.+|. T Consensus 324 K~~~~~~~a~~~~~~~~~~~~i~~~~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~ 403 (612) T 2C6F_A 324 DGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPE 403 (612) T ss_dssp SSCCCCCSCEEEECSSSSCEEEECCCCSCHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHHSHH T ss_pred CCCcceecchhhhCcCCCcEEEEEcCCCCHHHHHHHHHHHHHHHHHHHccCCCHHHccCCChHHHHHHHHHHHHHhcCHH Confidence 6655678888887764 689999999999999999999999999999988899998888889999999999999999999 Q sp|Q9BYF1|ACE2 417 HLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDET 496 (805) Q Consensus 417 hlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdet 496 (805) .|+.++++.. .+...+..++.++++++..+..+|+..+++.|+|.++.|.++.+.+-+.||+...+..|...|.+.+++ T Consensus 404 ~L~~~~~~~~-~~~~~~~~~~~l~~~~l~~l~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~l~~~y~g~~~~~~~~~~ 482 (612) T 2C6F_A 404 HLHKIGLLDR-VTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNET 482 (612) T ss_dssp HHHHTTSCCC-CCCSHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHHHHHHCEECSSCCCTT T ss_pred HHHHcCCCCC-CCCCcHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHhcCCCChhhHHHHHHHHHHHHcCCCCCCCCChh Confidence 9999988753 222234456788899999999999999999999999999888888999999988888887655555666 Q sp|Q9BYF1|ACE2 497 YCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGA 576 (805) Q Consensus 497 ycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvga 576 (805) ..||++..|+..+...+.|....+..+|+-+.+|+...+.+|+|+||+..+.++|+++.++|+.|.+.+|.-.++...|. T Consensus 483 ~~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~L~~G~s~~~~el~~~~~G~ 562 (612) T 2C6F_A 483 HFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGL 562 (612) T ss_dssp CCGGGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHHTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSC T ss_pred cCCcccceecCCChhhHHHHHHHHHHHHHHHHHHHHcCCCCChhhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHHHhCC Confidence 67788888876434467888888999999999999878889999999999999999999999999999999999999998 Q sp|Q9BYF1|ACE2 577 KNMNVRPLLNYFEPLFTWLKDQNKNSF--VGWSTDWS 611 (805) Q Consensus 577 knmnvrpllnyfeplftwlkdqnknsf--vgwstdws 611 (805) ...+..+++.+|+++..||+.+|++.- +||..+|- T Consensus 563 d~~~~~~~~~~~~~l~~~l~~~~~~~~~~~g~~~~~~ 599 (612) T 2C6F_A 563 DALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQW 599 (612) T ss_dssp SSCCSHHHHHHSHHHHHHHHHHHHHTTCCSSCSSTTC T ss_pred CCCCcHHHHHHHHHHHHHHHHHHHhcCCccCCCccCC Confidence 778889999999999999999988665 99997663 No 13 >5GIV_E Carboxypeptidase; M32 carboxypeptidase, Cobalt, Metallopeptidase, HYDROLASE; 2.4A {Deinococcus radiodurans str. R1} Probab=100.00 E-value=4.3e-52 Score=399.56 Aligned_cols=474 Identities=18% Similarity=0.185 Sum_probs=379.1 Template_Neff=9.400 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ++.+..+.+||.+.+.+...+-++.++++|++.|++++++.+.....- ++|++. ..+.+.+-.++-+|. T Consensus 3 ~~~~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~~~~~~----------~~l~~~-~~~~~~~~~~~~~l~ 71 (503) T 5GIV_E 3 TTRQDTQWQQLTEHWQELADFGGIEALLGWDQSTFLPAGAAEDRARQQ----------SLLAGL-RHARATDAGYGKLLD 71 (503) T ss_dssp ----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHH----------HHHHHH-HHHHHSCHHHHHHHH T ss_pred ccchHHHHHHHHHHHHHHHHHhcHHHHHHHHHHcCCCcchHHHHHHHH----------HHHHHH-HHHhhcCHHHHHHHH Confidence 567788999999999999999999999999999999998876544333 233332 133455666777777 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG-KQLR 177 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg-kqlr 177 (805) .++.. +.++++. ..++..|..+|..++ .++|.+.++|+++.+..+ ++|..||.+.+ +.++ T Consensus 72 ~l~~~--~~l~~~~----~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~ 132 (503) T 5GIV_E 72 AASSR--SDLSPEQ----ARMVQVARQDFEKAT-----------RIPAEFVREFSGHVGQSY--SAWTEARPANDFGRMV 132 (503) T ss_dssp HHHTC--SSCCHHH----HHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHH T ss_pred HHhcC--CCCCHHH----HHHHHHHHHHHHHhc-----------CCCHHHHHHHHhchhhHH--HHHHHHHHhCChhHhH Confidence 77655 2344433 344677888887765 467899999999998876 89999999977 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYE-DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhye-dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+|+++|-|+|+.|+.+.|+ ++.|||...|+- |...++++..|++|+|+|..||++||.+- T Consensus 133 ~~~~~~v~l~~~~A~~~g~~~~~yd~~l~~ye~----------~~~~~~l~~l~~~i~~~~~~l~~~v~~~~-------- 194 (503) T 5GIV_E 133 PYLEKTLDLSLQAASYFPEFGDPLDYYINESDE----------GMTAEQVGQVFAELRAALVPLADAVIAAG-------- 194 (503) T ss_dssp HHHHHHHHHHHHHHHTCTTCSSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHHHHHHHHHHHHhhCCCCCCHHHHHHHhcCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcC-------- Confidence 99999999999999999998 999999876653 44568899999999999999999999851 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ | .+..+.++..++++.+++||.++|++... +. .| T Consensus 195 ~~~---~--------------------------------~~~~~~~~~~~~~~~~~~~~~~lG~~~~~------~~-~d- 231 (503) T 5GIV_E 195 APR---T--------------------------------DFLGRGFAQERQLAFGERVIRDYGYDFRR------GR-QD- 231 (503) T ss_dssp CCC---C--------------------------------GGGGSCCCHHHHHHHHHHHHHHHTCCGGG------CC-EE- T ss_pred CCC---c--------------------------------hhhcCCCCHHHHHHHHHHHHHHhCCCccc------Cc-cc- Confidence 010 1 12334455677889999999999998621 11 11 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsa 412 (805) ..|||.+|+++.+|+||.||.+++ ++|+.+.|||+||++|.+.+..+ +..++.+++.+|||+++..|.+.. T Consensus 232 -----~~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~ 306 (503) T 5GIV_E 232 -----LTHHPFMTRLGGHDVRITTRVKEQDPTDALYSTLHEAGHALYEQGVDAAFLGTPLGGGVSAGVHESQSRLWENLV 306 (503) T ss_dssp -----ECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHTSCTTTTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred -----cCCCccccCCCCCcEEEEeecCCCChHHHHHHHHHHHHHHHHHcCCCHHHcCCCCCCccchHHHHHHHHHHHHhh Confidence 599999999988999999999999 69999999999999999988764 345578899999999999999999 Q sp|Q9BYF1|ACE2 413 AT---------PKHLKSIGLLSPDF-QEDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWW 478 (805) Q Consensus 413 at---------pkhlksigllspdf-qednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkww 478 (805) .+ |++++.+|.+-.+. .++-...+| .+++.++.-+-.+|+.++..+|+|-+|.|+++.+++.+.|| T Consensus 307 ~~~~~f~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~g~~~~~~l~~~w~ 386 (503) T 5GIV_E 307 GRSRAFWAAYFGDWRDTFPEQLAGVTEEEMYRAVNTVSRSLIRTDADELTYNLHVITRFELEREMLAGKLAVRDLADAWH 386 (503) T ss_dssp TTSHHHHHHHHHHHHHHSTTTTTTCCHHHHHHHTTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHH T ss_pred cCCHHHHHHHHHHHHHHCcHHhCCCCHHHHHHHHHhhCHHHhHHHhhhhhhcHHHHHHHHHHHHHhcCCCCHHHHHHHHH Confidence 99 99999988542222 222333444 45677777778888899999999999999999999999999 Q sp|Q9BYF1|ACE2 479 EMKREIVGVVEPVPHDETYCDPASLFHVSNDY---SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN--STEAGQK 553 (805) Q Consensus 479 emkreivgvvepvphdetycdpaslfhvsndy---sfiryytrtlyqfqfqealcqaakhegplhkcdisn--steagqk 553 (805) ++.++..|+..|. +...|+ ...|++.++ .|++|....++++|+.+++|+... .+|+| +.+ ..++|.. T Consensus 387 ~~~~~y~G~~~~~--~~~~~~--~~~h~~~~~~~~y~~~Y~~g~i~a~ql~~~~~~~~~---~~~~~-~~~~~~~~~~~~ 458 (503) T 5GIV_E 387 AAYEQNLGLRAPS--DVDGAL--QDVHWYFGPIGGSFQGYTIGNVLSAQFYAAAEAANP---GLEAD-FARKDFSRLHGW 458 (503) T ss_dssp HHHHHHHSCCCSS--STTTTT--SCSGGGSSCSSSSSHHHHHHHHHHHHHHHHHHHHST---THHHH-HHTTCCHHHHHH T ss_pred HHHHHHhCCCCCC--CCCCCc--ccccccccCcccCCHHHHHHHHHHHHHHHHHHHhCC---ChHHH-hhcCChHHHHHH Confidence 9999999987553 334454 467888765 479999999999999999998764 49999 863 4688999 Q sp|Q9BYF1|ACE2 554 LF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 554 lf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) |- ++++.|.+.||.-.++.+.|. .++..++++||+|+++||-+ T Consensus 459 l~~~il~~G~~~~~~ell~~~~g~-~ls~~~~l~y~~~~~~~~~~ 502 (503) T 5GIV_E 459 LRENVYRHGRRWTPGELIERATGQ-ALTAGPYLKYLRGKYGELYG 502 (503) T ss_dssp HCCCCCTTTTSSCHHHHHHHHHSS-SSCSHHHHHHHHHHHHHHHC T ss_pred HHHchHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 94 999999999999999999996 89999999999999999864 No 14 >5GIV_F Carboxypeptidase; M32 carboxypeptidase, Cobalt, Metallopeptidase, HYDROLASE; 2.4A {Deinococcus radiodurans str. R1} Probab=100.00 E-value=4.3e-52 Score=399.56 Aligned_cols=474 Identities=18% Similarity=0.185 Sum_probs=381.7 Template_Neff=9.400 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ++.+..+.+||.+.+.+...+-++.++++|++.|++++++.+.....- ++|++. ..+.+.+-.++-+|. T Consensus 3 ~~~~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~~~~~~----------~~l~~~-~~~~~~~~~~~~~l~ 71 (503) T 5GIV_F 3 TTRQDTQWQQLTEHWQELADFGGIEALLGWDQSTFLPAGAAEDRARQQ----------SLLAGL-RHARATDAGYGKLLD 71 (503) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHH----------HHHHHH-HHHHHTCHHHHHHHH T ss_pred ccchHHHHHHHHHHHHHHHHHhcHHHHHHHHHHcCCCcchHHHHHHHH----------HHHHHH-HHHhhcCHHHHHHHH Confidence 567788999999999999999999999999999999998876544333 233332 133455666777777 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG-KQLR 177 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg-kqlr 177 (805) .++.. +.++++. ..++..|..+|..++ .++|.+.++|+++.+..+ ++|..||.+.+ +.++ T Consensus 72 ~l~~~--~~l~~~~----~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~ 132 (503) T 5GIV_F 72 AASSR--SDLSPEQ----ARMVQVARQDFEKAT-----------RIPAEFVREFSGHVGQSY--SAWTEARPANDFGRMV 132 (503) T ss_dssp HHHHC--SCCCHHH----HHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHH T ss_pred HHhcC--CCCCHHH----HHHHHHHHHHHHHhc-----------CCCHHHHHHHHhchhhHH--HHHHHHHHhCChhHhH Confidence 77655 2344433 344677888887765 467899999999998876 89999999977 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYE-DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhye-dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+|+++|-|+|+.|+.+.|+ ++.|||...|+- |...++++..|++|+|+|..||++||.+- T Consensus 133 ~~~~~~v~l~~~~A~~~g~~~~~yd~~l~~ye~----------~~~~~~l~~l~~~i~~~~~~l~~~v~~~~-------- 194 (503) T 5GIV_F 133 PYLEKTLDLSLQAASYFPEFGDPLDYYINESDE----------GMTAEQVGQVFAELRAALVPLADAVIAAG-------- 194 (503) T ss_dssp HHHHHHHHHHHHHHHTCTTSSSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHHHHHHHHHHHHhhCCCCCCHHHHHHHhcCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcC-------- Confidence 99999999999999999998 999999876653 44568899999999999999999999851 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ | .+..+.++..++++.+++||.++|++... +. .| T Consensus 195 ~~~---~--------------------------------~~~~~~~~~~~~~~~~~~~~~~lG~~~~~------~~-~d- 231 (503) T 5GIV_F 195 APR---T--------------------------------DFLGRGFAQERQLAFGERVIRDYGYDFRR------GR-QD- 231 (503) T ss_dssp CCC---C--------------------------------GGGGSCCCHHHHHHHHHHHHHHHTCCTTS------CC-EE- T ss_pred CCC---c--------------------------------hhhcCCCCHHHHHHHHHHHHHHhCCCccc------Cc-cc- Confidence 010 1 12334455677889999999999998621 11 11 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsa 412 (805) ..|||.+|+++.+|+||.||.+++ ++|+.+.|||+||++|.+.+..+ +..++.+++.+|||+++..|.+.. T Consensus 232 -----~~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~ 306 (503) T 5GIV_F 232 -----LTHHPFMTRLGGHDVRITTRVKEQDPTDALYSTLHEAGHALYEQGVDAAFLGTPLGGGVSAGVHESQSRLWENLV 306 (503) T ss_dssp -----ECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHHSCGGGTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred -----cCCCccccCCCCCcEEEEeecCCCChHHHHHHHHHHHHHHHHHcCCCHHHcCCCCCCccchHHHHHHHHHHHHhh Confidence 599999999988999999999999 69999999999999999988764 345578899999999999999999 Q sp|Q9BYF1|ACE2 413 AT---------PKHLKSIGLLSPDF-QEDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWW 478 (805) Q Consensus 413 at---------pkhlksigllspdf-qednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkww 478 (805) .+ |++++.+|.+-.+. .++-...+| .+++.++.-+-.+|+.++..+|+|-+|.|+++.+++.+.|| T Consensus 307 ~~~~~f~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~g~~~~~~l~~~w~ 386 (503) T 5GIV_F 307 GRSRAFWAAYFGDWRDTFPEQLAGVTEEEMYRAVNTVSRSLIRTDADELTYNLHVITRFELEREMLAGKLAVRDLADAWH 386 (503) T ss_dssp TTSHHHHHHHHHHHHHHSHHHHTTCCHHHHHHHTTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHH T ss_pred cCCHHHHHHHHHHHHHHCcHHhCCCCHHHHHHHHHhhCHHHhHHHhhhhhhcHHHHHHHHHHHHHhcCCCCHHHHHHHHH Confidence 99 99999988542222 222333444 45677777778888899999999999999999999999999 Q sp|Q9BYF1|ACE2 479 EMKREIVGVVEPVPHDETYCDPASLFHVSNDY---SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN--STEAGQK 553 (805) Q Consensus 479 emkreivgvvepvphdetycdpaslfhvsndy---sfiryytrtlyqfqfqealcqaakhegplhkcdisn--steagqk 553 (805) ++.++..|+..|. +...|+ ...|++.++ .|++|....++++|+.+++|+... .+|+| +.+ ..++|.. T Consensus 387 ~~~~~y~G~~~~~--~~~~~~--~~~h~~~~~~~~y~~~Y~~g~i~a~ql~~~~~~~~~---~~~~~-~~~~~~~~~~~~ 458 (503) T 5GIV_F 387 AAYEQNLGLRAPS--DVDGAL--QDVHWYFGPIGGSFQGYTIGNVLSAQFYAAAEAANP---GLEAD-FARKDFSRLHGW 458 (503) T ss_dssp HHHHHHHSCCCSS--STTTTT--SCSGGGSSCSSSSSHHHHHHHHHHHHHHHHHHHHST---THHHH-HHTTCCHHHHHH T ss_pred HHHHHHhCCCCCC--CCCCCc--ccccccccCcccCCHHHHHHHHHHHHHHHHHHHhCC---ChHHH-hhcCChHHHHHH Confidence 9999999987553 334454 467888765 479999999999999999998764 49999 863 4688999 Q sp|Q9BYF1|ACE2 554 LF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 554 lf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) |- ++++.|.+.||.-.++.+.|. .++..++++||+|+++||-+ T Consensus 459 l~~~il~~G~~~~~~ell~~~~g~-~ls~~~~l~y~~~~~~~~~~ 502 (503) T 5GIV_F 459 LRENVYRHGRRWTPGELIERATGQ-ALTAGPYLKYLRGKYGELYG 502 (503) T ss_dssp HCCCCCTTTTSSCHHHHHHHHHSS-SCCSHHHHHHHHHHHHHHHC T ss_pred HHHchHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 94 999999999999999999996 89999999999999999864 No 15 >3HQ2_B Bacillus subtilis M32 carboxypeptidase (E.C.3.4.24.-); Hydrolase, Metal-binding, Metalloprotease, Protease; HET: PO4; 2.9A {Bacillus subtilis} Probab=100.00 E-value=1.1e-47 Score=361.19 Aligned_cols=473 Identities=16% Similarity=0.152 Sum_probs=365.7 Template_Neff=10.100 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++-|++||.+++.++.++.+.+++++|+|.||+|+++.+........ |+.. -.+.+++-.++-+|+.++ T Consensus 3 ~~~a~~~L~~~~~~~~~~~~~~~~~~Wd~~T~~p~~~~~~~~~~~~~----------l~~~-~~~~~~~~~~~r~l~~l~ 71 (501) T 3HQ2_B 3 IHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRAESIGQ----------LSTD-IFNIQTSDRMKELIDVLY 71 (501) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCCGGGHHHHHHHHHH----------HHHH-HHHHHHCHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHhHHHHHHHHHHHHHhCCCCCChHHHHHHHHH----------HHHH-HHHHhcCHHHHHHHHHHH Confidence 45689999999999999999999999999999999887654433322 2222 234667788899999998 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLRPL 179 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlrpl 179 (805) ..|. .|+++.. ..++.|..+|+.++ |- .|.+-+.++++ .++|.++|+.||.. + +.++|+ T Consensus 72 ~~~~-~l~~~~~----~~~~~~~~~~~~~~-~~----------~~~~~~~~~~~--~~~r~~~w~~~~~~-~~~~~~~~~ 132 (501) T 3HQ2_B 72 ERFD-DLSEDTK----KAVELAKKEYEENK-KI----------PEAEYKEYVIL--CSKAETAWEEAKGK-SDFSLFSPY 132 (501) T ss_dssp HTGG-GSCHHHH----HHHHHHHHHHHHHH-TS----------CHHHHHHHHHH--HHHHHHHHHHHHHH-TCHHHHHHH T ss_pred Hccc-CCCHHHH----HHHHHHHHHHHHcc-CC----------CHHHHHHHHHH--HHHHHHHHHHHHhc-CCHHHhHHH Confidence 8775 4665542 25788888898764 32 24444455544 45999999999986 6 789999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 258 (805) Q Consensus 180 yeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp 258 (805) +.++|-+++++|+.+.|++ ..|+|...|+- +.-.++++..|++|+|.|..+|+++|.|... T Consensus 133 l~~lv~l~~~~A~~~Gy~~~~~~~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~~~-------- 194 (501) T 3HQ2_B 133 LEQLIEFNKRFITYWGYQEHPYDALLDLFEP----------GVTVKVLDQLFAELKEAIIPLVKQVTASGNK-------- 194 (501) T ss_dssp HHHHHHHHHHHHHHHCCSSCTTHHHHTTTST----------TCCHHHHHHHHHHHHHHHHHHHHHHHSCSCC-------- T ss_pred HHHHHHHHHHHHHHccCCCChHHHHHHhhCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcCCC-------- Confidence 9999999999999999995 49999887762 2335789999999999999999999986310 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) | | +.+..+.+...++++.++.+|.+.|++.. .| T Consensus 195 ----p-----------~-------------------~~~~~~~~~~~~~~~~~~~~~~~~G~~~~-~~------------ 227 (501) T 3HQ2_B 195 ----P-----------D-------------------TSFITKAFPKEKQKELSLYFLQELGYDFD-GG------------ 227 (501) T ss_dssp ----C-----------C-------------------CTTTTSCCCHHHHHHHHHHHHHHHTCCGG-GC------------ T ss_pred ----C-----------C-------------------cchhcCcCCHHHHHHHHHHHHHHhCCCCC-CC------------ Confidence 1 0 11233445556678889999999998752 11 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYA-AQPF-LLRNGANEGFHEAVGEIMSLS-AA 413 (805) Q Consensus 339 vqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmaya-aqpf-llrnganegfheavgeimsls-aa 413 (805) .....|||.+|+++.+|+||.+|.. ..++|+.+.|||+||++|.+.+. .+|+ .++.+++.+|||+++..|.+. +. T Consensus 228 r~~k~~~~~~~~~~~~d~ri~~~~~~~~~~~~~~tl~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~~~ 307 (501) T 3HQ2_B 228 RLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNIDEALSGTNLSDGASMGIHESQSLFYENFIGR 307 (501) T ss_dssp CEEECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHTTSCGGGTTSTTCSCSCHHHHHHHHHHHCCCCCT T ss_pred CCCCCCCceeecCCCCceEEEEecChhhHHHHHHHHHHHHHHHHHHcCCCHHHCCCCccccccchhHHHHHHHHHHHhcC Confidence 1236899999999889999998877 56788999999999999999887 4887 789999999999999999988 66 Q sp|Q9BYF1|ACE2 414 TPKHLKSIGL-LSPDFQE--------DNETEINF----LLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (805) Q Consensus 414 tpkhlksigl-lspdfqe--------dneteinf----llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwem 480 (805) .+.+++.+.. ++..|.+ +-...+|. +.++++..+..+++......|+|-+|.|+++.+++.+.||++ T Consensus 308 ~~~~l~~~~~~~~~~~~~~l~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w~~~ 387 (501) T 3HQ2_B 308 NKHFWTPYYKKIQEASPVQFKDISLDDFVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQK 387 (501) T ss_dssp SGGGHHHHHHHHHHHSHHHHTTCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHTTTCCCGGGHHHHHHHH T ss_pred CHHHHHHHHHHHHHHCCccccCCCHHHHHHHHHhcCCCcchhHhHhhhHhHHHHHHHHHHHHHHcCCCCHhhHHHHHHHH Confidence 6666654422 2211111 11222332 333444445556666666799999999999889999999999 Q sp|Q9BYF1|ACE2 481 KREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL-FN 556 (805) Q Consensus 481 kreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl-fn 556 (805) ..+..|+..|. + ..++.+..|++.+| .+++|....++++|+.+++|+... .+|.|+. .+..++|++| -+ T Consensus 388 ~~~y~g~~~~~--~--~~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~~---~~~~~~~~~~~~~~~~~l~~~ 460 (501) T 3HQ2_B 388 YQDYLGITPQT--D--AEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLP---EFDALLERGEFHPIKQWLTEK 460 (501) T ss_dssp HHHHHSCCCCS--T--TTTGGGCSTTTTTCTTCTHHHHHHHHHHHHHHHHHHHHCT---THHHHHHTTCCHHHHHHHHHH T ss_pred HHHHhCCCCCC--C--CCcchhccccccccccCchHHHHHHHHHHHHHHHHHHhCc---cHHHHHHcCCchHHHHHHHHc Confidence 99999986553 2 26778889998764 488999999999999999998765 4899987 4566999999 49 Q sp|Q9BYF1|ACE2 557 MLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 557 mlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) +|..|.+.||.-.++.+.|. .+++++++.||+|+++|+.+ T Consensus 461 ~l~~G~s~~~~e~l~~~~G~-~l~~~~~l~~~~~~~~~~~~ 500 (501) T 3HQ2_B 461 VHIHGKRKKPLDIIKDATGE-ELNVRYLIDYLSNKYSNLYL 500 (501) T ss_dssp TGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHHHTTC T ss_pred ccccccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 99999999999999999998 89999999999999999864 No 16 >1K9X_B m32 carboxypeptidase; HEXXH motif, M32 family, metallopeptidase; 2.3A {Pyrococcus furiosus} SCOP: d.92.1.5 Probab=100.00 E-value=1.1e-46 Score=357.76 Aligned_cols=470 Identities=16% Similarity=0.193 Sum_probs=361.6 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) ..|+++.++|++++++...+.+++++++|+++||+++.+.+...++...++.++. +.+.+-.++-+|.. T Consensus 4 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~wd~~t~~~~~~~~~~~~~~~~l~~~~~-----------~~~~~~~~~~~l~~ 72 (499) T 1K9X_B 4 VFQNETIKQILAKYRRIWAIGHAQSVLGWDLEVNMPKEGILERSVAQGELSVLSH-----------ELLLHPEFVNLVEK 72 (499) T ss_dssp CCCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHH-----------HHHTCHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhHHHHHHHHHHHHHHHHH-----------HHhhCHHHHHHHHH Confidence 3578899999999999999999999999999999999998887776666655544 35567778888888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLR 177 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlr 177 (805) +++. +.+++. ...+++.|..+|..+. .+.|.+.++++++. ++|.++|+.||.. + +.++ T Consensus 73 ~~~~--~~l~~~----~~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~--~~~~~~w~~~~~~-~~~~~~~ 132 (499) T 1K9X_B 73 AKGL--ENLNEY----ERGIVRVLDRSIRIAR-----------AFPPEFIREVSETT--SLATKAWEEAKAK-DDFSKFE 132 (499) T ss_dssp HHHC--SSCCHH----HHHHHHHHHHHHHHHT-----------SSCHHHHHHHHHHH--HHHHHHHHHHHHT-TCGGGTH T ss_pred Hhcc--CCCCHH----HHHHHHHHHHHHHHHh-----------cCCHHHHHHHHHHH--HHHHHHHHHHHHc-CChHHhH Confidence 7765 344432 2346788888888764 46688999998875 6899999999984 7 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+++++|-++++.|+.+.|++ +.|||...|+- +...++++..|++|+|+|..||++++.+. . T Consensus 133 ~~l~~lv~l~~~~A~~~G~~~s~~d~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~--~----- 195 (499) T 1K9X_B 133 PWLDKIISLAKRAAEYLGYEEEPYDALLDLYEE----------GLRTRDVEKMFEVLEKKLKPLLDKILEEG--K----- 195 (499) T ss_dssp HHHHHHHHHHHHHHHHHCCSSCHHHHHHHHHST----------TCCHHHHHHHHHHCCCCCHHHHHHHHHHC--S----- T ss_pred HHHHHHHHHHHHHHHHcCCCCCHHHHHHHHhcC----------CCCHHHHHHHHHHHHHHHHHHHHHHHhcC--C----- Confidence 999999999999999999995 99999776653 34568999999999999999999999852 0 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ +.|+. .+-++..++++.+++||.++|++.++.|.. T Consensus 196 -----~~~-----------------~~p~~------------~~~~~~~~~~~~~~~~~~~lG~~~~~~~r~-------- 233 (499) T 1K9X_B 196 -----VPR-----------------EHPLE------------KEKYEREWMERVNLWILQKFGFPLGTRARL-------- 233 (499) T ss_dssp -----SCS-----------------CCGGG------------TCBCCHHHHHHHHHHHHHHHTCCBTTTEEE-------- T ss_pred -----CCC-----------------CCccc------------cccCCHHHHHHHHHHHHHHhCCCcccCCcc-------- Confidence 121 11221 122233457788999999999998853321 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAA-QPFL-LRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaa-qpfl-lrnganegfheavgeimslsa 412 (805) .-.|||.+|+++.+|+||.+|...+ ++|+.+.||||||+.|.+.+.. +|.+ ++.+++.+|||+++..|.... T Consensus 234 ----dk~~~~~~~~~~~~d~rI~~~~~~~~~~~~~~tl~HE~GHa~y~~~~~~~~~~~~~~~~~~~~~~E~~S~~~E~~~ 309 (499) T 1K9X_B 234 ----DVSAHPFTTEFGIRDVRITTRYEGYDFRRTILSTVHEFGHALYELQQDERFMFTPIAGGVSLGIHESQSRFWENII 309 (499) T ss_dssp ----EECSSCCEEEEETTEEEEEECCCSBCTHHHHHHHHHHHHHHHHHHTSCGGGTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred ----ccCCCCeeecCCcccEEEEeeecCccHHHHHHHHHHHHHHHHHHccCCccccCCcccccccchhHHHHHHHHHHHh Confidence 1589999999998999999999886 7899999999999999998875 5543 578899999999999998655 Q sp|Q9BYF1|ACE2 413 ATP----KHLKSIGLLSPDFQ-------EDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKW 477 (805) Q Consensus 413 atp----khlksigllspdfq-------ednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkw 477 (805) ..+ +++.. .++..+. ++-...++ .+++.++..+..++...+.-.|+|.+|.|+++.+++.+.| T Consensus 310 ~~~~~~~~~l~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w 387 (499) T 1K9X_B 310 GRSKEFVELIYP--VLKENLPFMSNYTPEDVYLYFNIVRPDFIRTEADVVTYNFHILLRFKLERLMVSEEIKAKDLPEMW 387 (499) T ss_dssp TTSHHHHHHHHH--HHHHHCGGGGGCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHSCCCGGGHHHHH T ss_pred cCCHHHHHHHHH--HHHHHCCCCCCCCHHHHHHHHhccCccccccccchhhHhHHHHHHHHHHHHHhcCCCCHHHhhHHH Confidence 433 33321 1222121 11112222 1222222233333334445678999999999999999999 Q sp|Q9BYF1|ACE2 478 WEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL 554 (805) Q Consensus 478 wemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl 554 (805) |++..+..|+..|. +. .+.....|++.++ .|++|....++++|+.+++|+.. |+++.|.. ....++|++| T Consensus 388 ~~~~~~y~G~~~~~--~~--~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~---~~~~~~~~~~~~~~~g~~l 460 (499) T 1K9X_B 388 NDEMERLLGIRPRK--YS--EGILQDIHWAHGSIGYFPTYTIGTLLSAQLYYHIKKDI---PDFEEKVAKAEFDPIKAWL 460 (499) T ss_dssp HHHHHHHHSCCCSS--GG--GTTTSCSHHHHTCCSCTHHHHHHHHHHHHHHHHHTTTC---TTHHHHHHHTCCHHHHHHH T ss_pred HHHHHHHhCCCCCC--CC--CcchhhccccccccccchHHHHHHHHHHHHHHHHHHHC---CcHHHHHHcCCcHHHHHHH Confidence 99999999987543 22 4667888988766 67899999999999999999875 36777744 3447899999 Q sp|Q9BYF1|ACE2 555 F-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 555 f-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) . ++++.|.+.||.-.++.+.|. .++..|+++||+|++. T Consensus 461 ~~~~l~~G~~~~~~e~l~~~~G~-~l~~~~ll~~~~~~~~ 499 (499) T 1K9X_B 461 REKIHRWGSIYPPKELLKKAIGE-DMDAEYFVRWVKEKYL 499 (499) T ss_dssp HHHTGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHC T ss_pred HHcchhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHhC Confidence 5 999999999999999999999 7999999999999873 No 17 >1KA2_A M32 carboxypeptidase; HEXXH motif, M32 family, metallopeptidase; 2.2A {Pyrococcus furiosus} SCOP: d.92.1.5 Probab=100.00 E-value=1.1e-46 Score=357.76 Aligned_cols=470 Identities=16% Similarity=0.193 Sum_probs=361.6 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) ..|+++.++|++++++...+.+++++++|+++||+++.+.+...++...++.++. +.+.+-.++-+|.. T Consensus 4 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~wd~~t~~~~~~~~~~~~~~~~l~~~~~-----------~~~~~~~~~~~l~~ 72 (499) T 1KA2_A 4 VFQNETIKQILAKYRRIWAIGHAQSVLGWDLEVNMPKEGILERSVAQGELSVLSH-----------ELLLHPEFVNLVEK 72 (499) T ss_dssp CSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHH-----------HHHTCHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhHHHHHHHHHHHHHHHHH-----------HHhhCHHHHHHHHH Confidence 3578899999999999999999999999999999999998887776666655544 35567778888888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLR 177 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlr 177 (805) +++. +.+++. ...+++.|..+|..+. .+.|.+.++++++. ++|.++|+.||.. + +.++ T Consensus 73 ~~~~--~~l~~~----~~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~--~~~~~~w~~~~~~-~~~~~~~ 132 (499) T 1KA2_A 73 AKGL--ENLNEY----ERGIVRVLDRSIRIAR-----------AFPPEFIREVSETT--SLATKAWEEAKAK-DDFSKFE 132 (499) T ss_dssp HHTC--SSCCHH----HHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHH--HHHHHHHHHHHHT-TCGGGTH T ss_pred Hhcc--CCCCHH----HHHHHHHHHHHHHHHh-----------cCCHHHHHHHHHHH--HHHHHHHHHHHHc-CChHHhH Confidence 7765 344432 2346788888888764 46688999998875 6899999999984 7 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+++++|-++++.|+.+.|++ +.|||...|+- +...++++..|++|+|+|..||++++.+. . T Consensus 133 ~~l~~lv~l~~~~A~~~G~~~s~~d~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~--~----- 195 (499) T 1KA2_A 133 PWLDKIISLAKRAAEYLGYEEEPYDALLDLYEE----------GLRTRDVEKMFEVLEKKLKPLLDKILEEG--K----- 195 (499) T ss_dssp HHHHHHHHHHHHHHHHHCCSSCHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHTT--C----- T ss_pred HHHHHHHHHHHHHHHHcCCCCCHHHHHHHHhcC----------CCCHHHHHHHHHHHHHHHHHHHHHHHhcC--C----- Confidence 999999999999999999995 99999776653 34568999999999999999999999852 0 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ +.|+. .+-++..++++.+++||.++|++.++.|.. T Consensus 196 -----~~~-----------------~~p~~------------~~~~~~~~~~~~~~~~~~~lG~~~~~~~r~-------- 233 (499) T 1KA2_A 196 -----VPR-----------------EHPLE------------KEKYEREWMERVNLWILQKFGFPLGTRARL-------- 233 (499) T ss_dssp -----SCS-----------------CCGGG------------TCBCCHHHHHHHHHHHHHHHTCCBTTTEEE-------- T ss_pred -----CCC-----------------CCccc------------cccCCHHHHHHHHHHHHHHhCCCcccCCcc-------- Confidence 121 11221 122233457788999999999998853321 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAA-QPFL-LRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaa-qpfl-lrnganegfheavgeimslsa 412 (805) .-.|||.+|+++.+|+||.+|...+ ++|+.+.||||||+.|.+.+.. +|.+ ++.+++.+|||+++..|.... T Consensus 234 ----dk~~~~~~~~~~~~d~rI~~~~~~~~~~~~~~tl~HE~GHa~y~~~~~~~~~~~~~~~~~~~~~~E~~S~~~E~~~ 309 (499) T 1KA2_A 234 ----DVSAHPFTTEFGIRDVRITTRYEGYDFRRTILSTVHEFGHALYELQQDERFMFTPIAGGVSLGIHESQSRFWENII 309 (499) T ss_dssp ----EECSSCCEEEEETTEEEEEECCCSBCTHHHHHHHHHHHHHHHHHHTCCGGGTTSTTSSCCCHHHHHHHHHCCCCCC T ss_pred ----ccCCCCeeecCCcccEEEEeeecCccHHHHHHHHHHHHHHHHHHccCCccccCCcccccccchhHHHHHHHHHHHh Confidence 1589999999998999999999886 7899999999999999998875 5543 578899999999999998655 Q sp|Q9BYF1|ACE2 413 ATP----KHLKSIGLLSPDFQ-------EDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKW 477 (805) Q Consensus 413 atp----khlksigllspdfq-------ednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkw 477 (805) ..+ +++.. .++..+. ++-...++ .+++.++..+..++...+.-.|+|.+|.|+++.+++.+.| T Consensus 310 ~~~~~~~~~l~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w 387 (499) T 1KA2_A 310 GRSKEFVELIYP--VLKENLPFMSNYTPEDVYLYFNIVRPDFIRTEADVVTYNFHILLRFKLERLMVSEEIKAKDLPEMW 387 (499) T ss_dssp TTSHHHHHHHHH--HHHHHCGGGGGCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHSCCCGGGHHHHH T ss_pred cCCHHHHHHHHH--HHHHHCCCCCCCCHHHHHHHHhccCccccccccchhhHhHHHHHHHHHHHHHhcCCCCHHHhhHHH Confidence 433 33321 1222121 11112222 1222222233333334445678999999999999999999 Q sp|Q9BYF1|ACE2 478 WEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL 554 (805) Q Consensus 478 wemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl 554 (805) |++..+..|+..|. +. .+.....|++.++ .|++|....++++|+.+++|+.. |+++.|.. ....++|++| T Consensus 388 ~~~~~~y~G~~~~~--~~--~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~---~~~~~~~~~~~~~~~g~~l 460 (499) T 1KA2_A 388 NDEMERLLGIRPRK--YS--EGILQDIHWAHGSIGYFPTYTIGTLLSAQLYYHIKKDI---PDFEEKVAKAEFDPIKAWL 460 (499) T ss_dssp HHHHHHHHSCCCSS--GG--GTTTSCSHHHHTCTTCTHHHHHHHHHHHHHHHHHHHHC---TTHHHHHHHTCCHHHHHHH T ss_pred HHHHHHHhCCCCCC--CC--CcchhhccccccccccchHHHHHHHHHHHHHHHHHHHC---CcHHHHHHcCCcHHHHHHH Confidence 99999999987543 22 4667888988766 67899999999999999999875 36777744 3447899999 Q sp|Q9BYF1|ACE2 555 F-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 555 f-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) . ++++.|.+.||.-.++.+.|. .++..|+++||+|++. T Consensus 461 ~~~~l~~G~~~~~~e~l~~~~G~-~l~~~~ll~~~~~~~~ 499 (499) T 1KA2_A 461 REKIHRWGSIYPPKELLKKAIGE-DMDAEYFVRWVKEKYL 499 (499) T ss_dssp HHHTGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHC T ss_pred HHcchhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHhC Confidence 5 999999999999999999999 7999999999999873 No 18 >5E3X_A Thermostable carboxypeptidase 1; Carboxypeptidase, Fervidobacterium, FisCP, HYDROLASE; 2.197A {Fervidobacterium islandicum} Probab=100.00 E-value=2.4e-46 Score=356.74 Aligned_cols=456 Identities=17% Similarity=0.229 Sum_probs=345.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 27 TFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSS 106 (805) Q Consensus 27 tfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalqqngss 106 (805) .||+.++.+++.+.++.++++|+|.||+++++.+.+..+...++.+ ..+.+++-+++-||+.++.. T Consensus 2 ~~l~~~~~~~~~~~~~~~~~~Wd~~t~~~~~~~~~r~~~~~~l~~~-----------~~~~~~~~~~~~~l~~~~~~--- 67 (489) T 5E3X_A 2 EELKSYYKRVAKYYSAAALLYWDMQTYMPKDAGPYRAEVLSEIGTY-----------AFKQITDDALGKLLETAQPQ--- 67 (489) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHH-----------HHHHHTSHHHHHHHHHCCCC--- T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCchHHHHHHHHHHHHH-----------HHHHhcCHHHHHHHHHhCCC--- Confidence 4889999999999999999999999999999998766665555543 33457788899999888752 Q sp|Q9BYF1|ACE2 107 VLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLRPLYEEYV 184 (805) Q Consensus 107 vlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlrplyeeyv 184 (805) +.+...++..|..+|++++++ .|.+-++++++.+..+ ++|..||.. + +.++|.|+++| T Consensus 68 ------~~~~~~~~~~~~~~~~~~~~~-----------~~~l~~~~~~~~~~~~--~~W~~~r~~-~~~~~~~~~~~~~v 127 (489) T 5E3X_A 68 ------SEIDEKLVYVGKKEYYKYKKV-----------PPELFQEIMITSTMLE--QKWEIAKPR-GDFEEVRPLLEKIV 127 (489) T ss_dssp ------SHHHHHHHHHHHHHHHHHHTS-----------CHHHHHHHHHHHHHHH--HHHHHHGGG-TCSTTTHHHHHHHH T ss_pred ------CHHHHHHHHHHHHHHHhccCC-----------CHHHHHHHHHhhhHHH--HHHHHHHhc-CCHHHHHHHHHHHH Confidence 234667788999999998763 4667788888888776 999999996 8 89999999999 Q sp|Q9BYF1|ACE2 185 VLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLP 263 (805) Q Consensus 185 vlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclp 263 (805) -+.|++|+.+.|++ .+++|...|+-. + ..++++..|++| +.+||..|.+.|+.. | T Consensus 128 ~l~~~~A~~~g~~~~~y~~~~~~y~~~----~------~~~~l~~~~~~l-------~~~v~~~l~~~~~~~-------~ 183 (489) T 5E3X_A 128 DLSRKYADILGYEGEPYNALLDLYEPG----M------KAEEVDQIFSKV-------RDFIVEVLEKIERLP-------K 183 (489) T ss_dssp HHHHHHHHTTCCSSCHHHHHHHHHSTT----C------CHHHHHHHHHHH-------HHHHHHHHHHHHHSC-------C T ss_pred HHHHHHHHHhCCCCChHHHHHHHhCCC----C------CHHHHHHHHHHH-------HHHHHHHHHHHhcCC-------C Confidence 99999999999987 568887766542 1 124455555554 556888887777431 3 Q sp|Q9BYF1|ACE2 264 AHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAV 343 (805) Q Consensus 264 ahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkav 343 (805) +| +.++.|+.. + .++.+. +.++.+.|... ++|... .. T Consensus 184 ~~-------------~~~~~~~~~----~-----------~~~~~~--~~~~~~~g~d~------------~~~~~~-~~ 220 (489) T 5E3X_A 184 SE-------------DPFNREIGV----D-----------KQKEFS--NWLLHYLKYDF------------TKGRLD-VS 220 (489) T ss_dssp CC-------------CTTCSCCCH----H-----------HHHHHH--HHHHHHTTCCT------------TSCCEE-EC T ss_pred CC-------------CcccCCCCH----H-----------HHHHHH--HHHHHHcCCCC------------CCCCee-cc Confidence 32 223333321 1 122222 45667777665 122221 38 Q sp|Q9BYF1|ACE2 344 CHPTAWDLGKGDFRILMCT--KVTMDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSAAT----- 414 (805) Q Consensus 344 chptawdlgkgdfrilmct--kvtmddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsaat----- 414 (805) |||..++++.+|+||.+|. +++++|+.+.|||+||++|.+.+..+ ...++.+++.+|||+++..|.+.... T Consensus 221 ~~~~~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~~~~l~~~ 300 (489) T 5E3X_A 221 AHPFTNPIGLNDVRITTRYIVNDIRNSIYSTIHEFGHALYALSIPTEFYGLPIGSSASYGFDESQSRFWENVVGRSLAFW 300 (489) T ss_dssp SSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHHSCGGGTTSGGGSCSCHHHHHHHHHCCCCCCTTSHHHH T ss_pred CCCccCCCCCCceEEeeeccccchhHHHHHHHHHHHHHHHHcCCChHHcCCCCccccCcccchhHHHHHHHHhhcCHHHH Confidence 9999999988999999999 99999999999999999999988752 22236789999999999999887776 Q sp|Q9BYF1|ACE2 415 ----PKHLKSIGLLSPDFQEDNETEINFLLKQALT-IVGT-------LPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKR 482 (805) Q Consensus 415 ----pkhlksigllspdfqedneteinfllkqalt-ivgt-------lpftymlekwrwmvfkgeipkdqwmkkwwemkr 482 (805) |+|++.+|++. +.. ..++...+.++.. ...+ ++...+...|+|.++.|+++.+++-+.||+... T Consensus 301 ~~~~~~~~~~l~~~~-~~~---~~~~~~~l~~~~~~~~~~~~d~l~~~~~~~~~~~~e~~~~~g~~~~~~l~~~w~~~~~ 376 (489) T 5E3X_A 301 KGIYSKFIEIVPEMR-GYS---VEELWRAVNRVQRSFIRTEADEVTYNLHIIIRFEIERELINGELSVKDVPDKWNELYK 376 (489) T ss_dssp HHHHHHHHHHCGGGT-TSC---HHHHHHHTSCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHHHHHH T ss_pred HHHHHHHHHHchhhc-CCC---HHHHHHHHHHHccccchhHhHHHHHHHHHHHHHHHHHHHHhCCCCHhhhhHHHHHHHH Confidence 77878887651 221 1122222222211 1121 244567799999999999999999999999999 Q sp|Q9BYF1|ACE2 483 EIVGVVEPVPHDETYCDPASLFHVSN-DY-SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-NS-TEAGQKLF-NM 557 (805) Q Consensus 483 eivgvvepvphdetycdpaslfhvsn-dy-sfiryytrtlyqfqfqealcqaakhegplhkcdis-ns-teagqklf-nm 557 (805) +..|+..|. + ..++....|+.. .| .+++|....++++|+.+++|+.. +++.| +. ++ .++|+.|- ++ T Consensus 377 ~y~g~~~~~--~--~~~~~~~~h~~~~~~~y~~~Y~~~~i~a~ql~~~~~~~~----~~~~~-~~~~~~~~~g~~l~~~~ 447 (489) T 5E3X_A 377 KYLGLDVPN--N--TLGCMQDPHWFGGNFGYFPTYALGNLYAAQIFEKLKEEI----NFEEV-VSAGNFEIIKNFLKEKI 447 (489) T ss_dssp HHHCCCCCS--T--TTTTTSCSGGGGTCCSCTHHHHHHHHHHHHHHHHHHHHS----CHHHH-HHHTCTHHHHHHHHHHT T ss_pred HHhCCCCCC--C--CCCCCCCCcccccccchhHHHHHHHHHHHHHHHHHHHcC----CHHHH-HhcCCHHHHHHHHHHch Confidence 999975443 2 235667788875 67 89999999999999999999865 69999 54 55 57899998 59 Q sp|Q9BYF1|ACE2 558 LRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 558 lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) +..|.+.||.-.++++.|. .+++++++.||+|++.|+.. T Consensus 448 l~~G~~~~~~e~l~~~~G~-~ls~~~~l~~~~~~~~~~~~ 486 (489) T 5E3X_A 448 HSKGKMYEPSDLIKIVTGK-PLSYESFVRYIKDKYSKVYE 486 (489) T ss_dssp GGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHHHHT T ss_pred hhcCcCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 9999999999999999998 89999999999999999974 No 19 >3HOA_A Thermostable carboxypeptidase 1 (E.C.3.4.17.19); proline-rich loop, Carboxypeptidase, Hydrolase; 2.1A {Thermus thermophilus HB27} Probab=100.00 E-value=1.1e-45 Score=356.95 Aligned_cols=468 Identities=19% Similarity=0.228 Sum_probs=373.5 Template_Neff=9.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++++..||++++.+...+-+..++++|++.|++++.+.+..... .++|+.. -.+.+.+-.++-+|..++ T Consensus 3 ~~~~~~~l~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~r~~~----------~~~l~~~-~~~~~~~~~~~~~l~~~~ 71 (509) T 3HOA_A 3 PEAAYQNLLEFQRETAYLASLGALAAWDQRTMIPKKGHEHRARQ----------MAALARL-LHQRMTDPRIGEWLEKVE 71 (509) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHH----------HHHHHHH-HHHHHTCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCCCHHhHHHHHHH----------HHHHHHH-HHHhhcCHHHHHHHHHHc Confidence 56788999999999999999999999999999998876443322 2233332 234566777888888887 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEV-GKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsev-gkqlrply 180 (805) .. ...+.+ ...+..++..|..+|...+ .++|.+.++|+++.++.+ ++|..||.+. +..++|.+ T Consensus 72 ~~-~~~~~~--~~~~~~~~~~~~~~~~~~~-----------~~~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~~~l 135 (509) T 3HOA_A 72 GS-PLVQDP--LSDAAVNVREWRQAYERAR-----------AIPERLAVELAQAESEAE--SFWEEARPRDDWRGFLPYL 135 (509) T ss_dssp TS-GGGSST--TSHHHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHHHHH T ss_pred CC-CCCCCC--CHHHHHHHHHHHHHHHHHc-----------CCCHHHHHHHHHcccHHH--HHHHHhhhhCChhhhHHHH Confidence 65 333332 4556678899999998766 678899999999999999 8999999998 89999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYE----------DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 181 eeyvvlknemaranhye----------dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +++|-++|+.|+.+.|. ++.|||...|+- |...++++..|++|+|+|..||+|||.+. T Consensus 136 ~~~v~l~~~~A~~~g~~~~~~~~~~~~~~~d~~l~~ye~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~-- 203 (509) T 3HOA_A 136 KRVYALTKEKAEVLFALPPAPGDPPYGELYDALLDGYEP----------GMRARELLPLFAELKEGLKGLLDRILGSG-- 203 (509) T ss_dssp HHHHHHHHHHHHHHHTSCCCTTSCCCCSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHTCS-- T ss_pred HHHHHHHHHHHHHhhcCCCCCCCCCCCCHHHHHHHccCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHccC-- Confidence 99999999999999997 999999988872 22358899999999999999999999964 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |. | |+|++ .+.+...+.++-++++|.+.|+.. ++ T Consensus 204 -~~----~----~~~~~-------------------------------~~~~~~~~~~~~~~~~~~~lG~~~------~~ 237 (509) T 3HOA_A 204 -KR----P----DTSIL-------------------------------HRPYPVEAQRRFALELLSACGYDL------EA 237 (509) T ss_dssp -CC----C----CGGGG-------------------------------GSCCCHHHHHHHHHHHHHHHTCCG------GG T ss_pred -CC----C----Cchhh-------------------------------cCCCCHHHHHHHHHHHHHHCCCCh------hh Confidence 21 1 44421 122233456788899999999886 12 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYAA----QPFLLRNGANEGFHEAV 404 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmayaa----qpfllrnganegfheav 404 (805) +. +. ..|||.+|+++.+|+||++|.. ..++++.+.|||+||..|.+.+.. +| ++.+++.+|||++ T Consensus 238 ~~------~d-k~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~--~~~~~~~~~~E~~ 308 (509) T 3HOA_A 238 GR------LD-PTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPKEHWGTP--RGDAVSLGVHESQ 308 (509) T ss_dssp EE------EE-ECSSCCEEEEETTEEEEEECCBTTBHHHHHHHHHHHHHHHHHHHHSCGGGTTSG--GGSCCCHHHHHHH T ss_pred CC------CC-CCCCcceeccCCCceEEEEeeccchhhHHHHHHHHHHHHHHHHhCCCHHHCCCC--CcCCCCchhHHHH Confidence 21 11 5799999999988999999998 899999999999999999998843 44 5678999999999 Q sp|Q9BYF1|ACE2 405 GEIMS----LSAATPKHLKS-----IGLLSPDFQEDNETEINF----LLKQALTIVGTLPFTYMLEKWRW--MVFKGEIP 469 (805) Q Consensus 405 geims----lsaatpkhlks-----igllspdfqedneteinf----llkqaltivgtlpftymlekwrw--mvfkgeip 469 (805) +..|. .+..+++++.. +|++++...++-...+|. ++++++..+. .|+.+++ +|+| .++.|+++ T Consensus 309 s~~~E~~~~~~~~~~~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~r~~~~~~~-~~~~~~~-~~~~E~~l~~~~~~ 386 (509) T 3HOA_A 309 SRTWENLVGRSLGFWERFFPRAREVFASLGDVSLEDFHFAVNAVEPSLIRVEADEVT-YNLHILV-RLELELALFRGELS 386 (509) T ss_dssp HHCCCCCCTTSHHHHHHHHHHHHHHCGGGTTCCHHHHHHHTTCCCCCSCGGGCCTTT-HHHHHHH-HHHHHHHHHTTSCC T ss_pred HHHHHHHhcCCHHHHHHHHHHHHHHhhccCCCCHHHHHHHHHccChhHHHHHhHHhH-hhHHHHH-HHHHHHHHHcCCCC Confidence 99998 67778877765 676544324444566666 7888887765 8998888 9999 89999999 Q sp|Q9BYF1|ACE2 470 KDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSND--YSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-- 545 (805) Q Consensus 470 kdqwmkkwwemkreivgvvepvphdetycdpaslfhvsnd--ysfiryytrtlyqfqfqealcqaakhegplhkcdis-- 545 (805) .+++-+.||+..++..|+..|. +...| ....|.+.. +.|.+|....++++|+.+++|+.. |+++.| +. T Consensus 387 ~~~l~~~w~~~~~~y~G~~~~~--~~~~~--~~~~h~~~~~~~Y~~~Y~~g~i~a~ql~~~~~~~~---~~~~~~-~~~~ 458 (509) T 3HOA_A 387 PEDLPEAWAEKYRDHLGVAPKD--YKDGV--MQDVHWAGGLFGYFPTYTLGNLYAAQFFQKAEAEL---GPLEPR-FARG 458 (509) T ss_dssp GGGHHHHHHHHHHHHHSCCCSS--STTTT--TSCSTTTTTCCSCTHHHHHHHHHHHHHHHHHHHHH---CCHHHH-HHHT T ss_pred HhHHhHHHHHHHHHHhCCCCCC--CCCCc--cccCcccCCccchhHHHHHHHHHHHHHHHHHHHHH---CChhHH-hhcC Confidence 9999999999999999987553 33333 444566543 345688899999999999999876 489999 54 Q sp|Q9BYF1|ACE2 546 NSTEAGQKLF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTW 594 (805) Q Consensus 546 nsteagqklf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftw 594 (805) +..++|..|- ++++.|.+.+|.-.++.+.|. .++..+++.||++.+.- T Consensus 459 ~~~~~g~~l~~~il~~G~s~~~~ell~~~~G~-~l~~~~~l~~~~~~~~~ 507 (509) T 3HOA_A 459 EFQPFLDWTRARIHAEGSRFRPRVLVERVTGE-APSARPFLAYLEKKYAA 507 (509) T ss_dssp CCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHhHHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHH Confidence 4579999997 899999999999999999998 89999999999987753 No 20 >3DWC_B Metallocarboxypeptidase (E.C.3.4.17.19); metallocarboxypeptidase, cowrin family of metallocarboxypeptidases; HET: GOL, SO4; 2.1A {Trypanosoma cruzi} Probab=100.00 E-value=2e-44 Score=343.88 Aligned_cols=459 Identities=16% Similarity=0.165 Sum_probs=360.6 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQE-I------QNLTVKL 95 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqe-i------qnltvkl 95 (805) ..|..||..++.+.+.+-++.++++|++.||+++.+.+.+..+..+++.++.+..+-.+++.+-+ + .+-..+. T Consensus 3 ~~~~~~l~~~~~~~~~l~~~~~~~~Wd~~t~~~~~~~~~~~~~~~~ls~~~~~~~~~~~~~~~~~~~~~~~~~ld~~~~r 82 (505) T 3DWC_B 3 MKPYKELERVFTKLYRYGHMLLLADWDSHTMMPCKGSDARGAAMAELQLHMHDTITAPKIRALIEEAEKSVGDLEKLQRA 82 (505) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHHHHHTSHHHHHHHHHHHHTGGGSCHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCCccHHHHHHHHHHHHHHHHhhhhCHHHHHHHHHHHhhcCCCCHHHHH Confidence 35778999999999999999999999999999999999999999999999999777555544211 1 1345677 Q sp|Q9BYF1|ACE2 96 QLQALQQN--GSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG 173 (805) Q Consensus 96 qlqalqqn--gssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg 173 (805) ||+.++.. ++..|+++.-++++.+.+.|+.+|++.+.||. . T Consensus 83 ~l~~l~~~~~~~~~lp~~~~~~~~~~~~~~~~~w~~~r~~~~-------------------------------------~ 125 (505) T 3DWC_B 83 NLREMRRAWELENLLPEEFVERKTVLTTKAHQVWKTCREKND-------------------------------------F 125 (505) T ss_dssp HHHHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHHHHHHHHTC-------------------------------------H T ss_pred HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHhhhcCC-------------------------------------h Confidence 78888887 88899999999999999999999999888731 1 Q sp|Q9BYF1|ACE2 174 KQLRPLYEEYVVLKNEMARANHYE---DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 174 kqlrplyeeyvvlknemaranhye---dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +.++|.++++|-++++.|+.+.|+ +..|+|...|+ .|...++++..|++|+|+|..||++||.++.. T Consensus 126 ~~~~~~~~~~v~l~~~~A~~~g~~~~~~~y~~~~~~y~----------~~~~~~~ld~l~~~i~~~~~~l~~~v~~~~~~ 195 (505) T 3DWC_B 126 AGFLPTLKELIALFREEGKLRAGNSGKHPYEALVDIYE----------PGMTLQRLDEIFGNVRSWLPELLKEVQEKQKA 195 (505) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTTSCCCHHHHHHHHHS----------TTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHcCCCCCChHHHHHHHhC----------CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 578999999999999999999986 77778866555 34455889999999999999999999998762 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |+ + +.+.+..||... ..++-++++|.++|... ++ T Consensus 196 -~~---------------~-------~~~~~~~p~~~~-----------------~~~~~~~~~~~~lg~~~------~~ 229 (505) T 3DWC_B 196 -LG---------------E-------TVLEPKGPFPVS-----------------KQEALCRFFMDVWKFDF------DG 229 (505) T ss_dssp -HC---------------C-------CCCCCCSCCCHH-----------------HHHHHHHHHHHHTTCCT------TS T ss_pred -hC---------------C-------CCCCCCCCCCHH-----------------HHHHHHHHHHHHcCCCc------cC Confidence 21 1 112334555221 23455677888888774 22 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAY-AA----QPFLLRNGANEGFHEA 403 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmay-aa----qpfllrnganegfhea 403 (805) +.+ | ..|||.+|+++ +|+||.+|.+ .+++|+.+.|||+||++|.+.+ .. ||+. .+++-+|||+ T Consensus 230 ~~~-d------~~~~~f~~~~~-~d~ri~~~~~~~~~~~~~~~l~HE~GHa~y~~~~~~~~~~~~p~~--~~~~~~~~E~ 299 (505) T 3DWC_B 230 GRL-D------VSAHPFCGNSK-EDVRITTKYTETEFVTSLLGVIHETGHAKYEQNCGPKGFETQPVC--MARSLGVHEG 299 (505) T ss_dssp EEE-E------ECSSCCEEEET-TEEEEEECCBTTBSHHHHHHHHHHHHHHHHHHTCCCTTCTTSTTS--SCSCHHHHHH T ss_pred Cce-e------ecCCCccCCCC-CceEEEecCCchHHHHHHHHHHHHHHHHHHHhcCCCccccCCchh--hhcccchhHH Confidence 222 2 38999999985 8999999999 7799999999999999999988 43 7875 6899999999 Q sp|Q9BYF1|ACE2 404 VGE----IMSLSAATPKHLKSIGLLSPDFQEDN-------ETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEI 468 (805) Q Consensus 404 vge----imslsaatpkhlksigllspdfqedn-------etein----fllkqaltivgtlpftymlekwrwmvfkgei 468 (805) ++. ++..++.+|+||..+... .|.... ..-++ .++++++..+..++...+...|+|-+|.|++ T Consensus 300 ~s~~~E~~~~~~~~~~~~l~~~~~~--~~~~~~~~~~~~l~~~l~~~~~~~~r~~~~~l~~~~~~~~~~~~e~~l~~g~~ 377 (505) T 3DWC_B 300 QSLFAEMQIGRSGAFMEFLAPRLVE--YFGDQPAFTSSNMKRVIQRVSPGLIRIDADELCYPLHVMLRYEIERDLMDGNI 377 (505) T ss_dssp HHHCCCCCCCTSHHHHHHHHHHHHH--HHCCCTTCSHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHTSS T ss_pred HHHHHHHHhhcCHHHHHHHHHHHHH--HHCCCCCCCHHHHHHHHhccCCcccHHHchhcchHHHHHHHHHHHHHHHcCCC Confidence 984 445677899999876322 222111 11122 3344444444444445566689999999999 Q sp|Q9BYF1|ACE2 469 PKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN 546 (805) Q Consensus 469 pkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdisn 546 (805) +.+++.+.||+..++..|+..|.. + .-++.+.+|++.++ .+++|....++++|+.+++|+...+ +|++.| +.+ T Consensus 378 ~~~~l~~~w~~~~~~y~g~~~~~~-~--~~~~~~~~H~~~~~~~Y~~~Y~~~~i~a~ql~~~~~~~~~~-~~~~~~-~~~ 452 (505) T 3DWC_B 378 EAEEVPRVWNEKMKSYLGLETLGN-D--KEGCLQDVHWSGGMFGYFPTYSLGAMVAAQLMSCVRRELGE-EVVDDC-IRK 452 (505) T ss_dssp CGGGHHHHHHHHHHHHHSCCCTTC-C--TTTTTSCSTTTTTCCSCTHHHHHHHHHHHHHHHHHHHHHCH-HHHHHH-HHT T ss_pred CHHHhhHHHHHHHHHHcCCCCCCC-C--cCCccccccccccccccchHHHHHHHHHHHHHHHHHHHHCc-ccHHHH-Hhc Confidence 999999999999999999876542 2 22568889988765 5789999999999999999998764 689999 543 Q sp|Q9BYF1|ACE2 547 STEAGQKL----FNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 547 steagqkl----fnmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) .++|..+ -++++.|.+.+|.-.++.+.|. +++..+++.||+|+++ T Consensus 453 -~~~~~~~~~l~~~~l~~G~s~~~~e~l~~~~G~-~l~~~~~~~~~~~~~~ 501 (505) T 3DWC_B 453 -GDLGKILAKQNEKIWQHGSSLTTDELLRQATGE-TLNPEHYRRHLERRYR 501 (505) T ss_dssp -TCCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-SCCTHHHHHHHCCCCC T ss_pred -CCHHHHHHHHHHhhhhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHh Confidence 7788876 4899999999999999999998 9999999999999885 No 21 >5WVU_C Thermostable carboxypeptidase 1 (E.C.3.4.17.19); carboxypeptidase, RIKEN Structural Genomics/Proteomics Initiative; HET: GOL; 2.6A {Thermus thermophilus HB8} Probab=100.00 E-value=8.4e-44 Score=344.00 Aligned_cols=469 Identities=20% Similarity=0.238 Sum_probs=368.7 Template_Neff=9.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++++..||++++.+...+-...++++|++.|++++.+.+.... ..++|+... .+.+.+-.++-+|..++ T Consensus 3 ~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~r~~----------~~~~l~~~~-~~~~~~~~~~~~l~~~~ 71 (510) T 5WVU_C 3 PEAAYQNLLEFQRETAYLASLGALAAWDQRTMIPKKGHEHRAR----------QMAALARLL-HQRMTDPRIGEWLEKVE 71 (510) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCGGGHHHHHH----------HHHHHHHHH-HHHHTCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCCCHhhHHHHHH----------HHHHHHHHH-HHhhcCHHHHHHHHHHc Confidence 4678899999999999999999999999999999887643322 123343332 34556677888888887 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEV-GKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsev-gkqlrply 180 (805) .. ...+.+ ......++..|..+|...+ .++|.+.++|+++.++.+ ++|+.||... +..++|.+ T Consensus 72 ~~-~~~~~~--~~~~~~~~~~~~~~~~~~~-----------~~~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~~~l 135 (510) T 5WVU_C 72 GS-PLVQDP--LSDAAVNVREWRQAYERAR-----------AIPERLAVELAQAESEAE--SFWEEARPRDDWRGFLPYL 135 (510) T ss_dssp TS-GGGSST--TSHHHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHHHHTCHHHHHHHH T ss_pred CC-CCCCCC--CHHHHHHHHHHHHHHHHHc-----------CCCHHHHHHHHHcccHHH--HHHHHHhhhCChhhhHHHH Confidence 65 333332 4455667888988888655 678999999999999998 7999999988 89999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYE----------DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 181 eeyvvlknemaranhye----------dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +++|-++|++|+.+.|. ++.|||...|+ +|...++++..|++|+|++..||+|+|.+. T Consensus 136 ~~~v~l~~~~A~~~g~~~~~~~~~~~~~~~d~~l~~y~----------~~~~~~~l~~l~~~l~~~~~~l~~~~~~~~-- 203 (510) T 5WVU_C 136 KRVYALTKEKAEVLFALPPAPGDPPYGELYDALLDGYE----------PGMRARELLPLFAELKEGLKGLLDRILGSG-- 203 (510) T ss_dssp HHHHHHHHHHHHHHHTSCCSTTSCCCCSHHHHHHHHHS----------TTCCHHHHHHHHHHHHHHHHHHHHHHHTTC-- T ss_pred HHHHHHHHHHHHHhhcCCCCCCCCCCCCHHHHHHHhcC----------CCCCHHHHHHHHHHHHHHHHHHHHHHHccC-- Confidence 99999999999999997 99999988776 223358899999999999999999999964 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |. | |+|++ .+.++..+.++-++++|.+.|+.. ++ T Consensus 204 -~~----~----~~~~~-------------------------------~~~~~~~~~~~~~~~~~~~lG~~~------~~ 237 (510) T 5WVU_C 204 -KR----P----DTSIL-------------------------------HRPYPVEAQRRFALELLSACGYDL------EA 237 (510) T ss_dssp -CC----C----CGGGG-------------------------------GSCCCHHHHHHHHHHHHHHHTCCG------GG T ss_pred -CC----C----Cchhh-------------------------------cCCCCHHHHHHHHHHHHHHCCCCc------hh Confidence 21 1 44421 122223446778889999999886 12 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYA----AQPFLLRNGANEGFHEAV 404 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmaya----aqpfllrnganegfheav 404 (805) +.+ | ..|||.+|+++.+|+||.+|.. .+++++.+.|||+||..|.+.+. -+| ++.+++.+|||+. T Consensus 238 ~~~-d------k~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~--~~~~~~~~~~E~~ 308 (510) T 5WVU_C 238 GRL-D------PTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPKEHWGTP--RGDAVSLGVHESQ 308 (510) T ss_dssp CCE-E------ECSSCCEEEEETTEEEEEECCBTTBHHHHHHHHHHHHHHHHHHHTSCGGGTTSG--GGSCSCHHHHHHH T ss_pred CCC-C------CCCCCceeecCCCceEEEEeeecchhhHHHHHHHHHHHHHHHHcCCCHHHCCCC--CccCCCchhHHHH Confidence 211 1 5799999999989999999998 89999999999999999999874 355 4578999999999 Q sp|Q9BYF1|ACE2 405 GEIMS----LSAATPKHLKS-----IGLLSPDFQEDNETEINF----LLKQALTIVGTLPFTYMLEKWRW--MVFKGEIP 469 (805) Q Consensus 405 geims----lsaatpkhlks-----igllspdfqedneteinf----llkqaltivgtlpftymlekwrw--mvfkgeip 469 (805) +..|. .+..++++|.. +|++++.-.++-...+|. ++++++..+. +|+.+++ +|+| -++.|+++ T Consensus 309 S~~~E~~~~~~~~~~~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~r~~~d~~~-~~~~~~~-~~~~e~~l~~~~~~ 386 (510) T 5WVU_C 309 SRTWENLVGRSLGFWERFFPRAREVFASLGDVSLEDFHFAVNAVEPSLIRVEADEVT-YNLHILV-RLELELALFRGELS 386 (510) T ss_dssp HHCCCCCCTTSHHHHHHHHHHHHHHCGGGTTCCHHHHHHHTTCCCCCSCSTTCCTTT-HHHHHHH-HHHHHHHHHHTSCC T ss_pred HHHHHHHhcCCHHHHHHHHHHHHHHhhccCCCCHHHHHHHHhccChhhhhHHhHHhH-hhHHHHH-HHHHHHHHhcCCCC Confidence 99998 66777777655 666544323333455666 7777777665 8998888 9999 89999999 Q sp|Q9BYF1|ACE2 470 KDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSND--YSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-- 545 (805) Q Consensus 470 kdqwmkkwwemkreivgvvepvphdetycdpaslfhvsnd--ysfiryytrtlyqfqfqealcqaakhegplhkcdis-- 545 (805) .+++-+.||++.++..|+..|. +...| ....|.+.. +.|.+|....++++|+.+++|+.. |+++.| +. T Consensus 387 ~~~l~~~w~~~~~~y~G~~~~~--~~~~~--~~~~h~~~~~~~Y~~~Y~~g~i~a~qi~~~~~~~~---~~~~~~-~~~~ 458 (510) T 5WVU_C 387 PEDLPEAWAEKYRDHLGVAPKD--YKDGV--MQDVHWAGGLFGYFPTYTLGNLYAAQFFQKAEAEL---GPLEPR-FARG 458 (510) T ss_dssp GGGHHHHHHHHHHHHHSCCCSS--STTTG--GGCSGGGGTCCSCTHHHHHHHHHHHHHHHHHHHHH---CCSHHH-HHTT T ss_pred hhhHhHHHHHHHHHHhCCCCCC--CCCCc--cccccccCCcccchHHHHHHHHHHHHHHHHHHHHH---CChhHH-hhcC Confidence 9999999999999999987553 23333 344555543 345588899999999999999876 489999 65 Q sp|Q9BYF1|ACE2 546 NSTEAGQKLF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWL 595 (805) Q Consensus 546 nsteagqklf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwl 595 (805) +..++|+.|- ++++.|.+.+|.-.++.+.|. .++..+++.||++.+.-| T Consensus 459 ~~~~~g~~l~~~~l~~G~s~~~~ell~~~~G~-~l~~~~~l~~~~~~~~~~ 508 (510) T 5WVU_C 459 EFQPFLDWTRARIHAEGSRFRPRVLVERVTGE-APSARPFLAYLEKKYAAL 508 (510) T ss_dssp CCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHhHHHcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHH Confidence 4478999987 899999999999999999998 899999999999987644 No 22 >3SKS_A Putative Oligoendopeptidase F; Structural Genomics, Center for Structural; HET: PO4; 2.05A {Bacillus anthracis} Probab=100.00 E-value=1.7e-38 Score=300.72 Aligned_cols=506 Identities=15% Similarity=0.182 Sum_probs=375.4 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQST-LA----QMYPLQEIQNLTVKLQ 96 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst-la----qmyplqeiqnltvklq 96 (805) ++++..+|..++.....+-...+.++|.|.+++|.+..+.+.......+..+..... +. +--+++++.. ..+-+ T Consensus 36 ~~~l~~~l~~~e~~~~~~~~~~~~a~~~~~~d~~d~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 114 (567) T 3SKS_A 36 VEEQKQVIHSINEIRNDFGTMGNLCYIRHSVDTTDAFYKEEQDFFDEFSPVVQGYGTKYYNALIHSPFREELEA-YYGKQ 114 (567) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhHHhHHHHHHHHHHHhcChhHHHHHH-HHHHH Confidence 456778899999888888899999999999999999877665544444433322211 11 1112222211 12335 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSVLSEDKS---KRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG 173 (805) Q Consensus 97 lqalqqngssvlsedks---krlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg 173 (805) ++.+.+.+...++++.. ..++.+.+.+..++++.++|.++ +++.+ +.+..+|++ -|...|-.+|++|+...+ T Consensus 115 l~~~~~~~~~~l~e~~e~~l~~~~~~~~~~~~~~~~~~~~~~g---~~~~~-~~~~~~l~~-~d~~~R~~~~~a~~~~~~ 189 (567) T 3SKS_A 115 LFALAECDLKTYSDEVVKDLQLENKLSSQYTQLLASAKIDFAG---EERTL-SQLIPFMQG-KERSERKAASEAYYGFLA 189 (567) T ss_pred HHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHHHhcCEEEeCC---EEEeH-HHHHHHHhC-CCHHHHHHHHHHHHHHHh Confidence 55566666666666422 23456668888999999999773 56666 889999996 899999999999998766 Q sp|Q9BYF1|ACE2 174 K---QLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 174 k---qlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) + .+++++.++|-+.+++|+.+.|.+|.+||.-.. .+.+|+...+..-++...++++|+|+.+|+++|.++-. T Consensus 190 ~~~~~~~~~l~~lv~~r~~~A~~~Gy~~~~~~~l~~~-----~~~~~~~~~~~~~l~~l~~~~~p~~~~~~~~~~~~lg~ 264 (567) T 3SKS_A 190 ENEEELDRIYDELVKVRTKIAKSLGFKNFVELGYARM-----YRTDYNAEMVANYRQQVLDYIVPVTTELRKRQQARIGV 264 (567) T ss_pred cCccchHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHh-----hhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCC Confidence 5 579999999999999999999999999997432 23455555555566666777999999999998876510 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFG-QKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLP------NM 323 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfg-qkpnidvtdamvdqawdaqrifkeaekffvsvglp------nm 323 (805) .++ +.|...+.++ .+ ..| .+....+++.++.+|-+.|.. .| T Consensus 265 -------------~~l------~~~d~~~~~~--~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 312 (567) T 3SKS_A 265 -------------EKL------AYYDENFEFP--TGNPTP-----------KGDADWIVNHGKTMYKELSAETDEFFNFM 312 (567) T ss_pred -------------CCC------CcccccCCCC--CCCCCC-----------CCCHHHHHHHHHHHHHhhCHHHHHHHHHH Confidence 011 3443333221 11 112 223457788888888888875 46 Q sp|Q9BYF1|ACE2 324 TQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHE 402 (805) Q Consensus 324 tqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaa-qpfllrnganegfhe 402 (805) ...+|-+ ....||....+.|++.. +.++++|+||...+.+|+.+.+|||||..+.+.... +|+..+. .+.+|+| T Consensus 313 ~~~~~iD-~~~r~~K~~g~~~~~~~---~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~-~~~~~~E 387 (567) T 3SKS_A 313 LDNDLLD-LVAKKGKAGGGYCTYIE---NYKAPFIFSNFNGTSGDIDVLTHEAGHAFQVYESRKFEIPEYNW-PTYEACE 387 (567) T ss_pred ccccccc-cCCCCCCCCCceeecCC---CCCCCEEEEeCCCCHHHHHHHHHHHHHHHHHHHccCCCCCCCCC-CCHHHHH Confidence 6667765 44556777778999854 457899999999999999999999999998887654 4554555 4568999 Q sp|Q9BYF1|ACE2 403 AVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFK-GEIPKDQWMKKWWEMK 481 (805) Q Consensus 403 avgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfk-geipkdqwmkkwwemk 481 (805) +++..|.+....+ |... +..+. + ..++.+++..+.++|+.+++.+|+|.++. |+++.+++-+.||+.. T Consensus 388 ~~S~~~E~l~~~~--l~~~------~~~~~--~-~~l~~~~~~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~~~~ 456 (567) T 3SKS_A 388 IHSMSMEFFTWPW--MKLF------FEEDA--D-KYYFSHLSSALLFLPYGVSVDEYQHYVYENPEASPEERKTAWRNIE 456 (567) T ss_pred HHHHHHHHHhHHH--HHHh------CCCHH--H-HHHHHHHHHHHhHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH Confidence 9999888877644 4321 11111 2 37888899999999999999999999997 8898899999999999 Q sp|Q9BYF1|ACE2 482 REIVGVVEPVPHD--ETYCDPASLFHVS-NDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNML 558 (805) Q Consensus 482 reivgvvepvphd--etycdpaslfhvs-ndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml 558 (805) ++.-|++.|.+.+ +..+++++..|+. .....+.|....+.++|+.+.+|.. +.++|.++.++| T Consensus 457 ~~y~g~~~~~~~~~~~~~~~w~~~~h~~~~~~y~~~Y~~~~~~a~~l~~~~~~~--------------~~~~~~~~~~~l 522 (567) T 3SKS_A 457 KKYLPHRDYEDNDYLERGGFWQRQGHIYSSPFYYIDYTLAQICALQFWKRARDN--------------RQEAWEDYVNLC 522 (567) T ss_pred HHHCCCCCCCCCCCccccCChhhCCccccCCchHHHHHHHHHHHHHHHHHHHHc--------------cHHHHHHHHHHH Confidence 9999987776654 5677888888887 4677889999999999999999874 246789999999 Q sp|Q9BYF1|ACE2 559 RLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK 600 (805) Q Consensus 559 rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnk 600 (805) +.|.+.||.-.++.+.|.....-..+.+++++|-.|++.+|. T Consensus 523 ~~G~s~~~~e~l~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~ 564 (567) T 3SKS_A 523 QQGGSKSFLELVEVANLTSPFAEGCVKSVITEIEAWLHAIDD 564 (567) T ss_pred HccCCCCHHHHHHHcCCCCCCChhHHHHHHHHHHHHHHHhhh Confidence 999999999999988776555566788899999999987663 No 23 >3AHN_A Oligopeptidase; HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HET: ACT, 3A1; 1.8A {Geobacillus sp. MO-1} Probab=100.00 E-value=2.6e-38 Score=299.31 Aligned_cols=505 Identities=14% Similarity=0.150 Sum_probs=360.1 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNN----AGDKWSAFLKEQ-STLAQMYPLQEIQNLTVKLQ 96 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnn----agdkwsaflkeq-stlaqmyplqeiqnltvklq 96 (805) ++++..+++.++.....+-...++++|.|.+|+|.+..+.+.. ...++...+.+. ..+.+-..++ .+. +-. T Consensus 33 ~~~~~~~l~~~e~~~~~~~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~---~~~-~~~ 108 (564) T 3AHN_A 33 AEEQNEAMKEINQLRNDFSTMAQICYIRHTIDTNDEFYKQEQDFFDEVEPIVKGLVNDYYRALVSSPFRS---QLE-GKW 108 (564) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCTTHH---HHH-HHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCchHH---HHh-hhh Confidence 4677788888888888888999999999999999988775432 222333332211 0111100011 110 011 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSV--LSEDKSKRLNTILNTMSTIYS----TGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS 170 (805) Q Consensus 97 lqalqqngssv--lsedkskrlntilntmstiys----tgkvcnpdnpqeclllepglneimansldynerlwaweswrs 170 (805) +..+.+..... ..+++-..+......++..|+ +.++|-.+ +++.+ +.+..+|. +-|...|-.+|++|+. T Consensus 109 ~~~~~~~~~~~l~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~~~g---~~~~~-~~~~~~~~-~~d~~~R~~~~~~~~~ 183 (564) T 3AHN_A 109 GKQLFALAEAELKTYSPDIVEDLQLENKLTSEYTKLVASAKIFFEG---EERTL-AQLQPFVE-SPDRDMRKRASEARFT 183 (564) T ss_dssp CTHHHHHHHHHHTTCCGGGHHHHHHHHHHHHHHHHHHHTCCEEETT---EEECT-GGGHHHHT-CSSHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhhcChhhHHHHHHHHHHHHHHHHHHhccEEEeCC---EEEeH-HHHHHHhc-CCCHHHHHHHHHHHHH Confidence 11111111111 223333444444556666666 88888542 35555 88999986 8899999999999999 Q sp|Q9BYF1|ACE2 171 EVGK---QLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAK 247 (805) Q Consensus 171 evgk---qlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvrak 247 (805) ..++ .++++|.+.|-+++++|+.+.|.+|.+||...+. ..+++...+..-++...++++|+|+.+++++|.. T Consensus 184 ~~~~~~~~~~~~~~~lv~~r~~~A~~~Gy~~~~~~~l~~~~-----~~~~~~e~~~~~~~~l~~~~~p~~~~~~~~~~~~ 258 (564) T 3AHN_A 184 FFQEHEEKFDEIYDQLVKVRTAIAQKLGFKNFVELGYARLG-----RTDYNAEMVAKFRKQVEKHIVPIAVKLRERQRER 258 (564) T ss_dssp HHHHTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHHHTT-----CCSCCHHHHHHHHHHHHHHTHHHHHHHHHHHHHH T ss_pred HHHHCHHHHHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHcc-----cCCCCHHHHHHHHHHHHHhchHHHHHHHHHHHHH Confidence 8876 6999999999999999999999999999964321 1345555555556666778899999999988864 Q sp|Q9BYF1|ACE2 248 LMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGF 327 (805) Q Consensus 248 lmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgf 327 (805) + |...-+.|... .||.....++. .++..+|+.++++|.+ ++.+...| T Consensus 259 l-------------------g~~~~~~~d~~----~~~~~~~~~~~--------~~~~~~~~~~~~~~~~--~~~~~~~~ 305 (564) T 3AHN_A 259 I-------------------GVEKLKYYDEA----FVFPTGNPMPK--------GDANWIIENGKKMYEE--LSPETGEF 305 (564) T ss_dssp H-------------------TCSSCCTTTTT----CCCTTCCCCCS--------SCHHHHHHHHHHHHHH--HCHHHHHH T ss_pred H-------------------Ccccccccccc----ccCCCCCCCCC--------CCHHHHHHHHHHHHHH--hCHHHHHH Confidence 3 32222334322 23332211111 1455677788888866 44455677 Q sp|Q9BYF1|ACE2 328 WENSM-------LTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (805) Q Consensus 328 wensm-------ltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegf 400 (805) |++.. ...||....+.|++.. ..+++||+||...+++|+.+.+||+||.++.+.+..++.+..++.+.+| T Consensus 306 ~~~~~~~~~~D~~~r~~K~~g~~~~~~~---~~~~~~i~~n~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~ 382 (564) T 3AHN_A 306 FRYMIEHELMDLVAKKGKASGGYCTYIE---NYKAPFIFSNFTGTSGDIDVLTHEAGHAFQVYESRHYEIPEYNWPTLEA 382 (564) T ss_dssp HHHHHHTTCEEEECCTTCCSSCEEEEEG---GGTEEEEEEEECSSTHHHHHHHHHHHHHHHHHHTTTCSSGGGSSCCHHH T ss_pred HHHHHHcCCcccccCCCCCCCceeeeec---CCCCcEEEEcCCCChhHHHHHHHHHHHHHHHHHccCCCCccccCCcHHH Confidence 77652 2345555568999865 3577899999999999999999999999998877666655556788999 Q sp|Q9BYF1|ACE2 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFK-GEIPKDQWMKKWWE 479 (805) Q Consensus 401 heavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfk-geipkdqwmkkwwe 479 (805) +|+.+..|.+....+ |+.. ++ +... ..++.+++.++..+|+.+++..|+|-++. |.++.+++-+.||+ T Consensus 383 ~E~~s~~~e~l~~~~--l~~~--~~-----~~~~--~~~~~~l~~~~~~l~~~~~~~~fe~~ly~~~~~~~~~~~~~~~~ 451 (564) T 3AHN_A 383 CEIHSMSMEFFTWPW--MKLF--FK-----EDAE--KYQFYHLSDALLFLPYGVAVDEFQHFVYENPNATPAERKQAWRA 451 (564) T ss_dssp HHHHHHHHHHHTGGG--HHHH--HG-----GGHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCCHHHHHHHHHH T ss_pred HHHHHHHHHHhhHHH--HHHH--cc-----chHH--HHhHHHHHHHHHHHHHHHHHHHHHHHHHhCCCCCHHHHHHHHHH Confidence 999999988877644 4431 11 1111 13445566778889999999999999999 88888999999999 Q sp|Q9BYF1|ACE2 480 MKREIVGVVEPVPHD--ETYCDPASLFHVSN-DYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFN 556 (805) Q Consensus 480 mkreivgvvepvphd--etycdpaslfhvsn-dysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfn 556 (805) +..+..|++.|.+.+ +..+++.+..|+.. ....+.|....+.++|+.+.+|+. +.++|.++.+ T Consensus 452 ~~~~y~g~~~~~~~~~~~~~~~w~~~~H~~~~~~yy~~Y~~s~~~a~~l~~~~~~~--------------~~~~~~~~~~ 517 (564) T 3AHN_A 452 IERKYMPTKDYDGNDYLERGGFWQRQSHIYTTAFYYIDYTLAQICAFQFWKRSREN--------------YKEAWNDYLT 517 (564) T ss_dssp HHHHHSTTCCCTTCHHHHTTCGGGGCHHHHHSTTTTHHHHHHHHHHHHHHHHHHHC--------------HHHHHHHHHH T ss_pred HHHHHCCCCCCCCCchhhcCCChhhccchhcCchHHHHHHHHHHHHHHHHHHHHHh--------------HHHHHHHHHH Confidence 999998876665544 56778888889875 556788999999999999988865 2568999999 Q sp|Q9BYF1|ACE2 557 MLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKN 601 (805) Q Consensus 557 mlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnkn 601 (805) +|+.|.+.||.-.++.+-|...+...+++.||+||..||+.+|+- T Consensus 518 ~l~~G~s~~~~e~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~ 562 (564) T 3AHN_A 518 LCRQGGSKPFTELVRVANLISPFEDGCVQSVVGGIEGWLNSVDDQ 562 (564) T ss_dssp HHTTTTSSCHHHHHHHTTCCCTTSTTHHHHHHHHHHHHHTTSCGG T ss_pred HHhcCCCCCHHHHHHHCCCCCCCChhHHHHHHHHHHHHHhccccc Confidence 999999999999999977767899999999999999999998864 No 24 >2QR4_A Peptidase M3B, oligoendopeptidase F; structural genomics, oligoendopeptidase F, PSI-2; 2.5A {Enterococcus faecium} Probab=99.95 E-value=2e-33 Score=267.60 Aligned_cols=506 Identities=14% Similarity=0.121 Sum_probs=318.6 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNN-AGDKWSAFLKEQSTLAQM---YPLQ---E-----IQN 90 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnn-agdkwsaflkeqstlaqm---yplq---e-----iqn 90 (805) +..+.+|+.++.....+-...+.+.|.+.++++.+..+.+.. ...+.+.+.+..+.+.+. .|.. + .+. T Consensus 34 ~~l~~~l~~~e~~~~~l~~~~~ya~~~~~~d~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~l~~~~~l 113 (587) T 2QR4_A 34 SQFLNAIEFVLRVYRQTEVIYVYAHLKNDQDTGNTDYQALYARASSLFSKVSEAVSWFEPEILQLSDDQIWQYFKEEPKL 113 (587) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHTTTHHHHHTTSCHHHHHHHHHHCGGG T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHhcchhHHHHcCCHHHHHHHHHhChhh Confidence 455666777777777788889999999999999986665443 333333333322222111 1111 1 112 Q sp|Q9BYF1|ACE2 91 LTVKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTG---KVCNPD----NPQECLLLEPGLNEIMANSLDYNE 160 (805) Q Consensus 91 ltvklqlqalqqngssvlsedkskrlnti---lntmstiystg---kvcnpd----npqeclllepglneimansldyne 160 (805) -..+-.|+.+.+.+...|+++..+.+.++ ++.++.+|++- .+|-++ +..++-+-.+.+..+|+ +-|... T Consensus 114 ~~~~~~l~~~~~~~~~~Ls~~~e~~l~~~~~~~~~~~~~y~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~~l~-~~d~~~ 192 (587) T 2QR4_A 114 EVYRHYIQQIVDNRAHVLSAEQESLLAGAGEIFDASSDTFAVLNNADLVFPTIEGENGEIVQLSHGVYGQLLE-STDRRV 192 (587) T ss_dssp GGGHHHHHHHHTTGGGCCCHHHHHHHHHTHHHHHHHHHHHHHCCCCCCCCCEEECTTSCEEECCHHHHHHHHT-CSCHHH T ss_pred HhhHHHHHHHHHcCCcCCCHHHHHHHHHHhhhhHHHHHHHHHHHhhccccCcccCCCCcEEEcCHHHHHHHhh-CCCHHH Confidence 25566777788888899999988877666 77888899884 666552 23333333456888999 899999 Q sp|Q9BYF1|ACE2 161 RLWAWESWRSEVG---KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLY 237 (805) Q Consensus 161 rlwaweswrsevg---kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikply 237 (805) |..+|++|++..+ ..+.++|.+++.+.+++|+.+.|.+|.+||..++++. -+.++..++.|++++ T Consensus 193 R~~~~~a~~~~~~~~~~~~~~~l~~lv~~~~~~A~~~Gy~~~~~~~l~~~~~~------------~~~~~~l~~~i~~~~ 260 (587) T 2QR4_A 193 REAAFKGLYSVYEQFRNTFASTLGTHIKGHNFKAKVRNYSSAREASLSNNHIP------------ESVYDTLVDVVNKHL 260 (587) T ss_dssp HHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHHTTTCC------------HHHHHHHHHHHHHTH T ss_pred HHHHHHHHHHHHHHhHHHHHHHHHHHHHhhHHHHHHcCCCCHHHHHHhhcCCC------------HHHHHHHHHHHHHhh Confidence 9999999998876 4899999999999999999999999999997765531 144557788999999 Q sp|Q9BYF1|ACE2 238 EHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQ--KPNIDVTDAMVDQAWDA-----QRIFKE 310 (805) Q Consensus 238 ehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgq--kpnidvtdamvdqawda-----qrifke 310 (805) ..+|+|+|.++.. + |. + . -+.|.. | .|+.. .+.+++ +..++....+ ..+++- T Consensus 261 ~~~~~~~~~~~~~-~-------g~-~-~------l~~~D~-~---~~~~~~~~~~~~~-~e~~~~~~~~~~~~~~~~~~~ 319 (587) T 2QR4_A 261 PLLHRYMELRKRL-L-------EV-E-K------LHMYDL-Y---TPVLGEAPITFTY-EEAKEKALEALKPMGEEYMAI 319 (587) T ss_dssp HHHHHHHHHHHHH-H-------TC-S-S------BCGGGS-S---SCSSCCCCC------CCHHHHHHHTGGGHHHHHHC T ss_pred HHHHHHHHHHHHH-h-------CC-C-C------cchhhc-C---CCCCCCCCCccCH-HHHHHHHHHHhHhhCHHHHHH Confidence 9999999876542 1 11 0 0 022322 1 22222 244554 2233332222 234444 Q sp|Q9BYF1|ACE2 311 AEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYA-AQP 389 (805) Q Consensus 311 aekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmaya-aqp 389 (805) ++++| +.| |-. +...||....+.|++.. .++++|+||...+.+|+.|.+||+||..+.+... .+| T Consensus 320 ~~~~~-~~~--------~id-~~~r~~K~~g~~~~~~~----~~~~~I~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~ 385 (587) T 2QR4_A 320 VEKAF-SER--------WID-VVENKGKRSGAYSSGSY----DTNPYILLNWHDTLDQLFTLVHEMGHSVHSYFTRSNQP 385 (587) T ss_dssp ------------------------------------------------------CHHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHH-HcC--------CeE-eecCCCCCCCceecCCC----CCCcEEEeecCCChHHHHHHHHHHHHHHHHHHhhcCCC Confidence 55544 333 211 11134555567787643 3589999999999999999999999999988776 678 Q sp|Q9BYF1|ACE2 390 FLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTI-VGTLPFTYMLEKWRWMVFKG-- 466 (805) Q Consensus 390 fllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqalti-vgtlpftymlekwrwmvfkg-- 466 (805) .+.+. .+.+|+|+++..|..-... + |+. .+ +...+++.+++++++- +++++...+...|.+-++.+ T Consensus 386 ~~~~~-~~~~~~E~~S~~~E~l~~~--~-----L~~-~~--~~~~~~~~l~~~~l~~~~~~l~~~~~~~~fe~~~~~~~~ 454 (587) T 2QR4_A 386 YVYGD-YSIFLAEIASTTNENILTE--Y-----LLE-TE--KDPRVRAYVLNHYLDGFKGTVFRQTQFAEFEHFMHTEDE 454 (587) T ss_dssp --------CHHHHHHHHHHHHHHHH--H-----HHH-HC--CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH T ss_pred hhhcc-CcHHHHHHHHHHHHHHHHH--H-----HHH-hC--CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 87775 6778888888777654322 2 321 11 1223478888888763 67888888888888888876 Q sp|Q9BYF1|ACE2 467 ---EIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCD 543 (805) Q Consensus 467 ---eipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcd 543 (805) .++.+.+.+-||+..++..|+..|.. ++..++....+|....|-...|..-.+.++|+.+.+|+. T Consensus 455 ~~~~l~~~~l~~~~~~~~~~~~g~~~~~~-~~~~~~w~~~~h~~~~~Y~~~y~~~~~~~~~l~~~~~~~----------- 522 (587) T 2QR4_A 455 KGVPLTSEYLSDSYGKLNAKYYGPAVEED-PEIKFEWSRIPHFYYNYYVFQYSTGFSAASALAKKILNQ----------- 522 (587) T ss_dssp TTCCCCHHHHHHHHHHHHHHHHCTTBCCC-GGGGGGGGGCGGGGSSSCTHHHHHHHHHHHHHHHHHHTT----------- T ss_pred cCCCCCHHHHHHHHHHHHHHHhCCCCCCC-hhhccHhHcCcchhcccccHHHHHHHHHHHHHHHHHHhc----------- Confidence 56678899999999999999876653 334556666677664444455555566677777777762 Q sp|Q9BYF1|ACE2 544 ISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSF 603 (805) Q Consensus 544 isnsteagqklfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsf 603 (805) +.++|.++..+|+.|.+.||.-.++. +|.......++..+|.|+-.||+..++..- T Consensus 523 ---~~~~~~~~~~~l~~G~s~~~~ell~~-~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~ 578 (587) T 2QR4_A 523 ---EPEALENYLAYLKAGNSDYPVEVMKK-AGVDMTQAAYIEDAMSMFEQRLNELEELID 578 (587) T ss_dssp ---CTTHHHHHHHHHHHCSCSCHHHHHHH-TTCCTTSSHHHHHHHHHHHHHHHHHHHHHH T ss_pred ---ChHHHHHHHHHHHcCCCCCHHHHHHH-cCCCCCCcHHHHHHHHHHHHHHHHHHHHHH Confidence 36789999999999999999999997 999988888999999999999998876543 No 25 >2O36_A Thimet oligopeptidase (E.C.3.4.24.15); thermolysin-like domain, substrate-binding channel, HYDROLASE; 1.95A {Homo sapiens} Probab=99.92 E-value=5e-30 Score=254.55 Aligned_cols=518 Identities=16% Similarity=0.181 Sum_probs=335.6 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 26 KTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP-------------LQEIQNLT 92 (805) Q Consensus 26 ktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp-------------lqeiqnlt 92 (805) ..++..++.....+....++++|.++++++++..+....+-.++++|..+..+-...|. +.+.+... T Consensus 47 ~~~v~~~d~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~ld~e~~r~ 126 (674) T 2O36_A 47 ESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARY 126 (674) T ss_dssp CCCCCHHHHHHHHHHHHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHSCTTCSCHHHHHH T ss_pred HHHHHHHHHhhHHHHHHHHHHhHHHHhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHHhhchhcCCHHHHHH Confidence 34566666667777888999999999999999999999999999999999877666665 23333445 Q sp|Q9BYF1|ACE2 93 VKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL 144 (805) Q Consensus 93 vklqlqalqqngssvlsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll 144 (805) ++..++.++++|.. |++++.+++..+ ++.+++.|+....|.+. .+ -++.+ T Consensus 127 l~~~l~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~-~~~~l 204 (674) T 2O36_A 127 LERLIKLGRRNGLH-LPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGK-LKVTL 204 (674) T ss_dssp HHHHHHHHHHTTTT-SCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECTTTTTTSCHHHHTTSEECTTSC-EEEES T ss_pred HHHHHHHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHccCCCccccceeHHHhcCCCHHHHHHHHhhhCCC-EEEec Confidence 66677788888865 666565666555 55578888888777643 12 13333 Q sp|Q9BYF1|ACE2 145 -EPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 -epglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) .|.+..+|+++-|...|..+|+.|+...++...+++++.+.+++++|+...|.+|.+||..+..+ .+..++. T Consensus 205 ~~~~~~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~ll~lR~~~A~llGy~s~~~~~l~~~~~-------~~~~~v~ 277 (674) T 2O36_A 205 KYPHYFPLLKKCHVPETRRKVEEAFNSRCKEENSAILKELVTLRAQKSRLLGFHTHADYVLEMNMA-------KTSQTVA 277 (674) T ss_dssp SHHHHHHHHHHCCCHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTT-------CSHHHHH T ss_pred CChhhHHHHhhCCCHHHHHHHHHHHHcCCchHHHHHHHHHHHHHHHHHHHhCCCCHHHHHhhccCC-------CCHHHHH Confidence 57789999999999999999999998877788999999999999999999999999999764332 2233444 Q sp|Q9BYF1|ACE2 224 EDVEHTFEEIKPLYEHLHAYVRAK---LMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ 300 (805) Q Consensus 224 edvehtfeeikplyehlhayvrak---lmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdq 300 (805) +-++...+.++|+|+..++.+++. ....+.. +..+.+ ..|...|-...... ...++.++.+.+ T Consensus 278 ~~l~~l~~~~~p~~~~~~~~l~~~~~~~~~~~g~--~~~~~l----------~~wD~~y~~~~~~~--~~~~~~~~~~~~ 343 (674) T 2O36_A 278 TFLDELAQKLKPLGEQERAVILELKRAECERRGL--PFDGRI----------RAWDMRYYMNQVEE--TRYCVDQNLLKE 343 (674) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC--CCCSSC----------CTTTHHHHHHHHCC--CCCCCCHHHHGG T ss_pred HHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHCCC--CCCCCC----------ChhcHHHHHHHHHH--hccCCCHHHHHh Confidence 445555678899998876655442 2222210 001111 23444444443322 234444555555 Q sp|Q9BYF1|ACE2 301 AWD----AQRIFKEAEKFFVSVGLPNM---TQGFWENSML-----------------T----DPGNVQKAVCHPTAWDLG 352 (805) Q Consensus 301 awd----aqrifkeaekffvsvglpnm---tqgfwensml-----------------t----dpgnvqkavchptawdlg 352 (805) .+. ...+++.++++| |+.-. ..-+|..+.. . .||....+.|++...+.. T Consensus 344 yf~~~~v~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~d~~~~~~lg~~ylD~~~r~~K~~~a~~~~~~~~~~ 420 (674) T 2O36_A 344 YFPVQVVTHGLLGIYQELL---GLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCL 420 (674) T ss_dssp GCBHHHHHHHHHHHHHHHH---TEEEEECTTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEEEECCEE T ss_pred hCCHHHHHHHHHHHHHHHh---CcEEEeCCCCCcccCCceEEEEEeCCCCcEEEEEEEeCCCCCCCCCCCceeeEeCCcc Confidence 443 245666666666 43221 2345665553 1 234433455554332211 Q sp|Q9BYF1|ACE2 353 K--GDF-----RI---------LMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEG--FHEAVGEIMSLSAAT 414 (805) Q Consensus 353 k--gdf-----ri---------lmctkvtmddfltahhemghiqydmayaaqpfllrnganeg--fheavgeimslsaat 414 (805) . |+. .| -.|+.++++|+.|.+||+||..+.+.+..++..+ .|.+-+ |+|+++.+|.+.+.. T Consensus 421 ~~~~~~~~P~~~i~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~-~g~~~~~d~~E~~S~~~E~~~~~ 499 (674) T 2O36_A 421 RQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVRTYFHEFGHVMHQLCSQAEFAMF-SGTHVETDFVEAPSQMLENWVWE 499 (674) T ss_dssp CTTSCEECEEEEEECCCCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCCSSGGG-STTCSCTTTTTHHHHHHHGGGGS T ss_pred cCCCCeeceEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhcCCcccc-cCCcccchhhcchhHHHHHhhcC Confidence 0 111 22 1578888999999999999999999988766554 566655 999999999999999 Q sp|Q9BYF1|ACE2 415 PKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIP---KDQWMKKWWEMKREIVGVVEPV 491 (805) Q Consensus 415 pkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeip---kdqwmkkwwemkreivgvvepv 491 (805) |++|+.++.-..+-+.-.+..++.++.. ....+..++++.+.+-.|..++- .+++.+.||++.++..|+ |+ T Consensus 500 ~~~L~~l~~~~~~~~~l~~~~~~~l~~~----~~~~~~~~~~~~~~~~~~d~~l~~~~~~~~~~~~~~l~~~~~g~--~~ 573 (674) T 2O36_A 500 QEPLLRMSRHYRTGSAVPRELLEKLIES----RQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGV--PA 573 (674) T ss_dssp HHHHHHTCCCTTTCCCCCHHHHHHHHHG----GGTTHHHHHHHHHHHHHHHHHHTTCSSCCHHHHHHHHCCCCCSS--CC T ss_pred hHHHHHHcccCCCCCCCCHHHHHHHHHH----hhHhHHHHHHHHHHHHHHHHHHhCCCCCCHHHHHHHHHHHHhCC--CC Confidence 9999988743221111112233333321 11222222333444434433332 356889999999999887 33 Q sp|Q9BYF1|ACE2 492 PHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQ-AAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLA 569 (805) Q Consensus 492 phdetycdpaslfhvsndysfiryytrtlyqfqfqealcq-aakhegplhkcdisnsteagqklf-nmlrlgksepwtla 569 (805) +. ...++.+..|+..+|.+ .|| .-++..-+...+.+ ..+..||+ +.++|.++. ++|..|.+.+|.-. T Consensus 574 ~~--~~~~~~~~~Hl~~~y~~-~yy-~Yl~s~vlA~~i~~~~f~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~e~ 642 (674) T 2O36_A 574 TP--GTNMPATFGHLAGGYDA-QYY-GYLWSEVYSMDMFHTRFKQEGVL-------NSKVGMDYRSCILRPGGSEDASAM 642 (674) T ss_dssp CT--TCCGGGGCGGGGTTCTT-CTT-HHHHHHHHHHHHCCCCCCHHCTT-------CHHHHHHHCCCCCTTGGGSCHHHH T ss_pred CC--CCCCcccHHHHHhcchH-HHH-HHHHHHHHHHHHHHHHHHhhCCC-------CHHHHHHHHHhccccCCCcCHHHH Confidence 32 24577888898766655 344 22222111111111 11223343 458899999 89999999999999 Q sp|Q9BYF1|ACE2 570 LENVVGAKNMNVRPLLNYF 588 (805) Q Consensus 570 lenvvgaknmnvrpllnyf 588 (805) ++++.|. .++..+++.++ T Consensus 643 l~~~lG~-~~~~~~~l~~~ 660 (674) T 2O36_A 643 LRRFLGR-DPKQDAFLLSK 660 (674) T ss_dssp HHHHHSS-CCCSHHHHHHT T ss_pred HHHHhCC-CCCHHHHHHHc Confidence 9999995 78888888765 No 26 >3CE2_A Crystal structure of putative peptidase; structural genomics, UNKNOWN FUNCTION, putative; 2.6A {Chlamydophila abortus} Probab=99.92 E-value=1.1e-29 Score=244.31 Aligned_cols=507 Identities=15% Similarity=0.108 Sum_probs=330.6 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGD-KWSAFLKEQSTL---AQMYPLQEI-------QNL 91 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagd-kwsaflkeqstl---aqmyplqei-------qnl 91 (805) +..+.+++.+......+-...+.+++.+.++.+.+..+.+.+... ..+.+...-+.+ .+..+-+++ +.- T Consensus 67 ~~~~~~l~~~e~~~~~l~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~l~~~~~~ 146 (618) T 3CE2_A 67 ESLLSLLTTLFSIERKLNKLYVYAHLTHDQDITNQEGIADLKSITHLHTLFAEETSWVQPALTSLSESLIAQHLSAPCLA 146 (618) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHTTTHHHHHHTSCHHHHHHHHHCSTTG T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHhhhhhHHHHhcCCHHHHHHHhcCccch Confidence 455667777777778888889999999999998876665554333 222222211111 011111111 223 Q sp|Q9BYF1|ACE2 92 TVKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYST---GKVCNPD---NPQECLLLEPG-LNEIMANSLDYNER 161 (805) Q Consensus 92 tvklqlqalqqngssvlsedkskrlnti---lntmstiyst---gkvcnpd---npqeclllepg-lneimansldyner 161 (805) ..+..|+.+...+...|++++.+++..+ +..++.+|++ ..+|-+. ...+++-+.++ ...+|. +-|...| T Consensus 147 ~~~~~l~~~~~~~~~~Ls~~~e~~l~~l~~~l~~~~~~~~~l~~~~~~~~~~~~~~g~~~~l~~~~~~~~l~-~~d~~~R 225 (618) T 3CE2_A 147 PYRFYLEKIFRLSIHTGTPGEEKILASAFTPLEVASKAFSSLSDSEIPFGQATDSEGNSHPLSHALASLYMQ-STDRELR 225 (618) T ss_dssp GGHHHHHHHHTTGGGCCCHHHHHHHHHHTTGGGHHHHHHHCCCCCCSCCCEEECSSCCEEECCHHHHHHHHT-CSCHHHH T ss_pred hhHHHHHHHHHhCCccCCHHHHHHHHHhcChhHHHHHHHHHHHcccccccceeCCCCCEEECCHHHHHHHcc-CCCHHHH Confidence 4566777766667777888877665544 4466666765 4555431 12245555655 677777 8899999 Q sp|Q9BYF1|ACE2 162 LWAWESWRSEV---GKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYE 238 (805) Q Consensus 162 lwaweswrsev---gkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplye 238 (805) --+|+.|.... .....+++.+.+-+++++|+...|.+|.+|+..+++++ -+.++..++.|++++. T Consensus 226 k~~~~a~~~~~~~~~~~~~~~l~~l~~~r~~~A~~~Gy~s~~~~~l~~~~~~------------~~~~~~l~~~v~~~~~ 293 (618) T 3CE2_A 226 KTSYLAQCERYHSYRHTFANLLNGKIQAHVFYAKNKRYNSCLQAALYHNNIP------------TTVYTNLIDIVKKNSS 293 (618) T ss_dssp HHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTTTCC------------HHHHHHHHHHHHTTHH T ss_pred HHHHHHHHHHHHhcHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHhcCCC------------HHHHHHHHHHHHHchH Confidence 99999998764 35688899999999999999999999999997654431 2566678888899999 Q sp|Q9BYF1|ACE2 239 HLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQ--KPNIDVTDAMVDQAWDAQRIFKEAEKFFV 316 (805) Q Consensus 239 hlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgq--kpnidvtdamvdqawdaqrifkeaekffv 316 (805) .+|+|++.+.... |.-+-..|...| |+.+ ++.+++.++. ..+++....++. T Consensus 294 ~~~~~~~~~~~~~----------------g~~~l~~wD~~~----~~~~~~~~~~~~~~~~-------~~v~~~l~~~~~ 346 (618) T 3CE2_A 294 LITKYFSIKQRCL----------------NLKDFHFYDVYA----PLSQSKEKKYTFQEAV-------DLIYTSLSPLGT 346 (618) T ss_dssp HHHHHHHHHHHHH----------------TCSSCBGGGTTC----CSCC--CCCCCHHHHH-------HHHHHHTGGGHH T ss_pred HHHHHHHHHHHHc----------------CCCCcchhhhcC----CCCcccCCccCHHHHH-------HHHHHHhhhcCH Confidence 9999999876531 222444554444 3332 3455554431 122222222221 Q sp|Q9BYF1|ACE2 317 SVGLPNMTQGFWENSM---LTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYA-AQPFLL 392 (805) Q Consensus 317 svglpnmtqgfwensm---ltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmaya-aqpfll 392 (805) .++- .+...|+.+.. ...||....+.|++.. .++.+|+||...+++|+.|.+||+||..+.+.+. .+|+.. T Consensus 347 ~~~~-~~~~~~~~~~~iD~~~r~~K~~ga~~~~~~----~~~~~I~~n~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~ 421 (618) T 3CE2_A 347 EYID-TLKQGLTTQGWVDKYENLNKRSGAYSSGCY----DSHPYVLLNYTGTLYDVSVIAHEGGHSMHSYFSRKHQPFHD 421 (618) T ss_dssp HHHH-HHHHHHHTSCCEECSCCTTCCCSCEEECCT----TSCCEEECCCCSSHHHHHHHHHHHHHHHHHHHHHHHSCGGG T ss_pred HHHH-HHHHHHhhcCceecccCCCCCCCccccCCC----CCCcEEEEecCCCchHHHHHHHHHHHHHHHHHHHhcCchhh Confidence 1110 01112322222 2234555667887632 2578999999999999999999999999998776 478876 Q sp|Q9BYF1|ACE2 393 RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALT-IVGTLPFTYMLEKWRWMVF----KG- 466 (805) Q Consensus 393 rnganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqalt-ivgtlpftymlekwrwmvf----kg- 466 (805) +. ...+|+|+++..|.+-...+. ++ +.. +.+..++ ++.+.+. ++.+++...+...|..-++ .| T Consensus 422 ~~-~~~~~~E~~S~~~E~l~~~~~-~~-------~~~-~~~~~~~-~l~~~l~~~~~~~~~~~~~~~fe~~l~~~~~~~~ 490 (618) T 3CE2_A 422 AQ-YPIFLAEIASTLNEMLLMDSM-LK-------ESD-SKEEKIT-ILTRCLDTIFSTLFRQVLFASFEYDIHHAAEHGV 490 (618) T ss_dssp CS-CCGGGTTHHHHHHHHHHHHHH-HH-------HCC-CHHHHHH-HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHTTC T ss_pred cC-CCHHHHHHHHHHHHHHhHHHH-Hh-------hCC-CHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCC Confidence 64 456899999888876655442 11 111 1122344 4444444 4446666655555555555 45 Q sp|Q9BYF1|ACE2 467 EIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN 546 (805) Q Consensus 467 eipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisn 546 (805) +++.+++.+.||++.++..|+..|.+ ++..+++++..|+-..|-...|..-.+..+++.+.+|. + T Consensus 491 ~l~~~~l~~~~~~~~~~~~g~~~~~~-~~~~~~w~~~~h~~~~~Y~y~y~~~~~~a~~l~~~~~~--------------~ 555 (618) T 3CE2_A 491 PLTEEYLSSTYKNLQNEFYGEIITFD-VLSNIEWARIPHFYYNFYVYQYATGIIAALCFLEKILN--------------N 555 (618) T ss_dssp CCCHHHHHHHHHHHHHHHHTTTCBCC-TTGGGGGGGSCGGGCSSCTHHHHHHHHHHHHHHHHHHT--------------T T ss_pred CCCHHHHHHHHHHHHHHHhCCCCCCc-cccccHhhccchhhcchhcHHHHHHHHHHHHHHHHHHh--------------C Confidence 67778999999999999999877665 35566777777764222222222223444555444432 3 Q sp|Q9BYF1|ACE2 547 STEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKN 601 (805) Q Consensus 547 steagqklfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnkn 601 (805) ..++|.++.++|+.|.+.||.-.++. .|.......++..+|.|+..||+..++. T Consensus 556 ~~~~~~~~~~~L~~G~s~~~~el~~~-~g~~~~~~~~~~~~~~~l~~~l~~~~~~ 609 (618) T 3CE2_A 556 EDNALNSYLNFLKSGGSDFPLEILKK-SGLDMGTVEPIQKAFCFIEKKIQELSSL 609 (618) T ss_dssp CTTHHHHHHHHHTTTTSSCHHHHHHH-TTCCTTSSHHHHHHHHHHHHHHHHHHTT T ss_pred CchHHHHHHHHHHccCCCCHHHHHHH-cCCCCCCCHHHHHHHHHHHHHHHHHHHH Confidence 46789999999999999999999984 9999888999999999999999988764 No 27 >2O3E_A Neurolysin (E.C.3.4.24.16); thermolysin-like domain, substrate-binding channel, HYDROLASE; 2.2A {Rattus norvegicus} Probab=99.90 E-value=9.4e-29 Score=246.41 Aligned_cols=515 Identities=14% Similarity=0.179 Sum_probs=346.7 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 31 KFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-------------PLQEIQNLTVKLQL 97 (805) Q Consensus 31 kfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-------------plqeiqnltvklql 97 (805) .+......+-...+.++|-+.++.+++..+..+.+..+++++..+..+-...| .+.+.+...++..+ T Consensus 68 ~ld~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~ly~~l~~~~~~~~~~~ld~e~~~~l~~~~ 147 (678) T 2O3E_A 68 VLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSI 147 (678) T ss_dssp HHHHHHHHHHHHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHCCTTSSCHHHHHHHHHHH T ss_pred HHHHhhhhhHHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHhcccHhhCCHHHHHHHHHHH Confidence 33333333556677888999999999999999999999999988875544444 35555666778888 Q sp|Q9BYF1|ACE2 98 QALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL-EPGL 148 (805) Q Consensus 98 qalqqngssvlsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll-epgl 148 (805) +.++++|.. |++++.+++..+ +..++..|+....|... .+ .++.+ .|.+ T Consensus 148 ~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~g-~~~~l~~~~~ 225 (678) T 2O3E_A 148 KMGKRNGLH-LSEHIRNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDK-YKVTLKYPHY 225 (678) T ss_dssp HHHHHTTTT-SCHHHHHHTHHHHHHHHHHHHHHHHHHHHCCCEEEEETTTTTTCCHHHHHTSCBCSSSE-EEEESSHHHH T ss_pred HHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcceeCCHHHHcCCCHHHHHHHhcCCCCC-cEEEcCCccH Confidence 899999975 777666666544 44555556666665421 12 23444 5678 Q sp|Q9BYF1|ACE2 149 NEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEH 228 (805) Q Consensus 149 neimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedveh 228 (805) ..+|+++-|...|..+|+.|....++..++++++.+.+++++|+...|++|.+||..++.+ ++..++.+-.+. T Consensus 226 ~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~ll~lr~~~A~~lGy~s~~~~~l~~~~~-------~s~~~v~~~l~~ 298 (678) T 2O3E_A 226 FPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHADFVLELNTA-------KSTSRVAAFLDD 298 (678) T ss_dssp HHHHHHCCCHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTT-------CSHHHHHHHHHH T ss_pred HHHHHhCCCHHHHHHHHHHhhcCCchhHHHHHHHHHHHHHHHHHHhCCCCHHHHHhccCCC-------CCHHHHHHHHHH Confidence 8999999999999999999998777788999999999999999999999999999876643 233445555666 Q sp|Q9BYF1|ACE2 229 TFEEIKPLYEHLHAYVRAKLMNAYPSY-ISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRI 307 (805) Q Consensus 229 tfeeikplyehlhayvraklmnaypsy-ispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqri 307 (805) ..+.++|++++++++++.......+.+ .++.+.+ ..|...|-...+. +...+++++.+.+-+....+ T Consensus 299 l~~~~~p~~~~~~~~l~~~~~~~~~~~g~~~~~~l----------~~wD~~~~~~~~~--~~~~~~~~~~~~~yf~~~~v 366 (678) T 2O3E_A 299 LSQKLKPLGEAEREFILSLKKKECEERGFEYDGKI----------NAWDLHYYMTQTE--ELKYSVDQESLKEYFPIEVV 366 (678) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCSSC----------CHHHHHHHHHHHH--HHHTCCCHHHHGGGCBHHHH T ss_pred HHHHhHHHHHHHHHHHHHHHHHHhHHcCCCcCCCC----------CcccHHHHHHHHH--HhcCCCCHHHHHhhCCHHHH Confidence 778899999999999987443322211 1111122 3455555554433 22455656666655555444 Q sp|Q9BYF1|ACE2 308 ----FKEAEKFFVSVGLPNM-TQGFWENSMLT---------------------DPGNVQKAVCHPTAWDL--GKG----D 355 (805) Q Consensus 308 ----fkeaekffvsvglpnm-tqgfwensmlt---------------------dpgnvqkavchptawdl--gkg----d 355 (805) ++-++++| .+++... ...+|..+... .||.-..+.|.+...+. ..| . T Consensus 367 ~~~l~~~~~~~f-g~~~~~~~~~~~W~~~v~~~~v~~~~~~~~~g~~ylD~~~r~~K~~~~~~~~~~~~~~~~~g~~~~p 445 (678) T 2O3E_A 367 TEGLLSIYQELL-GLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMS 445 (678) T ss_dssp HHHHHHHHHHHH-TEEEEECTTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEEEECCBBCTTSCBCCE T ss_pred HHHHHHHHHHHh-CCEEEECCCCCCccCCCeEEEEEECCCCcEEEEEEEECCCCCCCCCCcceeeecCCccCCCCCeeCe Confidence 34444444 4444332 23457665541 23332233343322211 111 3 Q sp|Q9BYF1|ACE2 356 FRILMCTKV----------TMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLL 424 (805) Q Consensus 356 frilmctkv----------tmddfltahhemghiqydmayaa-qpfllrnganegfheavgeimslsaatpkhlksigll 424 (805) +++++|... +.+|+.|.+||+||..+.+.... +|.+...+...+|+|+.+.+|...+..|.+|+.++.. T Consensus 446 ~~~i~~n~~~~~~~~~~ll~~~~~~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~l~E~~~~~~~~L~~l~~~ 525 (678) T 2O3E_A 446 VAALVVNFSQPVAGRPSLLRHDEVETYFHEFGHVMHQICAQTDFARFSGTNVERDFVEVPSQMLENWVWDVDSLRKLSKH 525 (678) T ss_dssp EEEEECCCCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCBSSGGGSTTCSCTTTTTHHHHHHHGGGGCHHHHHHHCCC T ss_pred EEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhcCCcHHHcCCcccchhhchhHHHhHHhhcCHHHHHHHhcc Confidence 567877653 89999999999999999877652 3333333467899999999999999999999999876 Q sp|Q9BYF1|ACE2 425 SPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 425 spdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) ..+-+.-.+..++.+++ +++.++..+++. .++. .++.+.. . ..-+.||++.++..|+ |++.+ .+. T Consensus 526 ~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~d~---~l~~~~~-~-~~~~~~~~~~~~~~g~--~~~~~--~~~ 595 (678) T 2O3E_A 526 YKDGHPITDELLEKLVASRLVNTGLLTLRQIVLS-KVDQ---SLHTNAT-L-DAASEYAKYCTEILGV--AATPG--TNM 595 (678) T ss_dssp SSSCCCCCHHHHHHHHHTTTTTHHHHHHHHHHHH-HHHH---HHTTCTT-S-CHHHHHHHHCCCCCSS--CCCTT--CCG T ss_pred CCCCCCCCHHHHHHHHHhhhhhHHHHHHHHHHHH-HHHH---HHhcCCC-c-cHHHHHHHHHHHHHCC--CCCCC--CCC Confidence 65544445667888888 788888888776 4454 3455542 2 2357888877777786 43322 456 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSF--IRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFN-MLRLGKSEPWTLALENVVGA 576 (805) Q Consensus 500 paslfhvsndysf--iryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfn-mlrlgksepwtlalenvvga 576 (805) +.+..|..++|.+ ..|........++-+++|+. .||+ +.++|+++.+ +|..|.+.||.-.++.+.|. T Consensus 596 ~~~~~hl~~~y~~~Yy~Yl~s~vla~~i~~~~~~~---~~~~-------~~~~g~~~~~~~l~~G~s~~~~e~l~~~~g~ 665 (678) T 2O3E_A 596 PATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKK---EGIM-------NPEVGMKYRNLILKPGGSLDGMDMLQNFLQR 665 (678) T ss_dssp GGGCTTSSSSCTTCTTHHHHHHHHHHHHCCCCCCH---HCTT-------CHHHHHHHCCCCCTTGGGSCHHHHHHHHHTS T ss_pred cccHHHHHccchHHHHHHHHHHHHHHHHHHHHHHh---cCCC-------CHHHHHHHHHHhcccCCCCCHHHHHHHHhCC Confidence 7888898776644 23333333444444443321 2333 3589999998 99999999999999999995 Q sp|Q9BYF1|ACE2 577 KNMNVRPLLNYF 588 (805) Q Consensus 577 knmnvrpllnyf 588 (805) .+++.+++.|+ T Consensus 666 -~~~~~~ll~~~ 676 (678) T 2O3E_A 666 -EPNQKAFLMSR 676 (678) T ss_dssp -CCCSHHHHHHH T ss_pred -CCCHHHHHHHc Confidence 79999988875 No 28 >5LV0_A Neurolysin, mitochondrial (E.C.3.4.24.16), GLY-VAL-VAL amyloid; PROTEASE, MITOCHONDRIA, HYDROLASE, amyloid-beta; 2.7A {Homo sapiens} Probab=99.89 E-value=6.2e-28 Score=240.22 Aligned_cols=504 Identities=15% Similarity=0.198 Sum_probs=338.6 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 41 YQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP-------------LQEIQNLTVKLQLQALQQNGSSV 107 (805) Q Consensus 41 yqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp-------------lqeiqnltvklqlqalqqngssv 107 (805) .....+.|.++++.+++..+..+.+..++++|..+..+-..+|. +.+-+...++..++.++.+|.. T Consensus 83 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~l~~e~~~~l~~~l~~~~~~G~~- 161 (686) T 5LV0_A 83 VERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLH- 161 (686) T ss_dssp HHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHSCTTTSCHHHHHHHHHHHHHHHHTTTT- T ss_pred hHHHHhhhHHhhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHhccchhcCCHHHHHHHHHHHHHHHHcCCC- Confidence 44556788899998888888888899999999888765455553 2233334456666777888876 Q sp|Q9BYF1|ACE2 108 LSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL-EPGLNEIMANSLDY 158 (805) Q Consensus 108 lsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll-epglneimansldy 158 (805) |++++.+++..+ +..+++.|+....|... ++ .++-+ .|.+..+|+++-|. T Consensus 162 L~~~~~~~~~~l~~~~~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~-~~~~l~~~~~~~~l~~~~d~ 240 (686) T 5LV0_A 162 LPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDK-YKITLKYPHYFPVMKKCCIP 240 (686) T ss_dssp SCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECTTTTTTCCHHHHHHSCBCTTSC-EEEESSHHHHHHHHHHCCCH T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHccCCCCceeeCCHHHHcCCCHHHHHHHhccCCCC-eEEEcCCccHHHHHHhCCCH Confidence 455555666665 66667777776665421 11 23333 46788899999999 Q sp|Q9BYF1|ACE2 159 NERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYE 238 (805) Q Consensus 159 nerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplye 238 (805) ..|-.+|+.|....++...+++++.+.+++++|+...|.+|.+||...+.+. +...+.+-++...+.++|+++ T Consensus 241 ~~R~~~~~a~~~~~~~~n~~~l~~ll~lR~~~A~~lG~~s~~~~~l~~~~~~-------~~~~v~~~l~~l~~~~~p~~~ 313 (686) T 5LV0_A 241 ETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAK-------STSRVTAFLDDLSQKLKPLGE 313 (686) T ss_dssp HHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTTC-------SHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCchhHHHHHHHHHHHHHHHHHHhCCCCHHHHHhhccCCC-------CHHHHHHHHHHHHHHhHHHHH Confidence 9999999999887666888999999999999999999999999998776543 233444445556678899999 Q sp|Q9BYF1|ACE2 239 HLHAYVRAKLMNAYPSYISP-IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVS 317 (805) Q Consensus 239 hlhayvraklmnaypsyisp-igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs 317 (805) .+++++++......+.+-.+ .+.+ ..|...|-+.... +..++++++.+.+.+....+++.+..++-+ T Consensus 314 ~~~~~l~~~~~~~~~~~g~~~~~~l----------~~wD~~~~~~~~~--~~~~~~~~~~~~~yf~~~~v~~~~~~~~~~ 381 (686) T 5LV0_A 314 AEREFILNLKKKECKDRGFEYDGKI----------NAWDLYYYMTQTE--ELKYSIDQEFLKEYFPIEVVTEGLLNTYQE 381 (686) T ss_dssp HHHHHHHHHHHHHHHHHTCCCCSSC----------BTTTHHHHHHHHH--HHHHCCCHHHHGGGCBHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHchhCCCCcCCCC----------ChhhHHHHHHHHH--HHhcCCCHHHHHhhCCHHHHHHHHHHHHHH Confidence 99999976444322111001 1111 2344444443332 235667777777777777777777777666 Q sp|Q9BYF1|ACE2 318 -VGLPNM---TQGFWENSML---------------------TDPGNVQKAVCHPTAWDLGKG-----DFR-----ILMC- 361 (805) Q Consensus 318 -vglpnm---tqgfwensml---------------------tdpgnvqkavchptawdlgkg-----dfr-----ilmc- 361 (805) .|+.-. ...+|.++.. ..+|.-..+.|.+ +..+ +.+ +++| T Consensus 382 lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~~lg~~~lD~~~r~~K~~~a~~~~----~~~~~~~~~~~~~~p~~~i~~n 457 (686) T 5LV0_A 382 LLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFG----LQPGCLLPDGSRMMAVAALVVN 457 (686) T ss_dssp HHTEEEEEETTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEE----EECCCBCTTSSBCCEEEEEECC T ss_pred HHCcEEEECCCCCccCCCceEEEEEECCCCcEEEEEEEECCCCCCCCCCcceee----eeCCccCCCCCeeCeEEEEEec Confidence 665433 2335665533 1234333344443 3222 122 4554 Q sp|Q9BYF1|ACE2 362 ---------TKVTMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQED 431 (805) Q Consensus 362 ---------tkvtmddfltahhemghiqydmayaa-qpfllrnganegfheavgeimslsaatpkhlksigllspdfqed 431 (805) +.++++|+.|.+||+||..+.+.+.. +|.+...+....|+|+.+.+|..-+..|++|+.++....+-+.- T Consensus 458 ~~~~~~~~~~~l~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~l~~~~~~~~~~ 537 (686) T 5LV0_A 458 FSQPVAGRPSLLRHDEVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPI 537 (686) T ss_dssp CCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCCSSSTTSTTCSCTTTTTHHHHHHHGGGGCHHHHHHHCCCTTTCCCC T ss_pred CCCCCCCCCCCCChHHHHHHHHHHHHHHHHHHhcCCcHHHcCCCccchhchHhHHHhHHhhcCHHHHHHHhhhcCCCCCC Confidence 56699999999999999999987764 56666667889999999999999999999999988665544333 Q sp|Q9BYF1|ACE2 432 NETEINFLLKQ-----ALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHV 506 (805) Q Consensus 432 neteinfllkq-----altivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycdpaslfhv 506 (805) .+..++.+++. ++.++..+++. +++. .++.+.. ....+.|+++.++..|+ |.+. ....+.+..|. T Consensus 538 ~~~~~~~l~~~~~~~~~~~~~~~l~~~-~~d~---~l~~~~~--~~~~~~~~~~~~~~~g~--~~~~--~~~~~~~~~hl 607 (686) T 5LV0_A 538 ADDLLEKLVASRLVNTGLLTLRQIVLS-KVDQ---SLHTNTS--LDAASEYAKYCSEILGV--AATP--GTNMPATFGHL 607 (686) T ss_dssp CHHHHHHHHHGGGTTHHHHHHHHHHHH-HHHH---HHTTCCS--SCHHHHHHHHCCCCCCS--BCCT--TCCSGGGCGGG T ss_pred CHHHHHHHHHhhhHhHHHHHHHHHHHH-HHHH---HHhcCCC--ccHHHHHHHHHHHHhCC--CCCC--CCCCccccHHH Confidence 45667777776 67777777655 5664 3455542 23578899987887785 3322 23567777888 Q sp|Q9BYF1|ACE2 507 SNDYSFIRYYTRTLYQFQFQEALC-QAAKHEGPLHKCDISNSTEAGQKLFN-MLRLGKSEPWTLALENVVGAKNMNVRPL 584 (805) Q Consensus 507 sndysfiryytrtlyqfqfqealc-qaakhegplhkcdisnsteagqklfn-mlrlgksepwtlalenvvgaknmnvrpl 584 (805) ..+|.. .||.. ++..-+...+. +..+..||+ +.++|.++.+ +|..|.+.+|.-.++.+.|. .++..++ T Consensus 608 ~~~y~~-~yY~Y-l~s~~~A~~i~~~~f~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~e~l~~~~G~-~~~~~~l 677 (686) T 5LV0_A 608 AGGYDG-QYYGY-LWSEVFSMDMFYSCFKKEGIM-------NPEVGMKYRNLILKPGGSLDGMDMLHNFLKR-EPNQKAF 677 (686) T ss_dssp TTTCTT-CTTHH-HHHHHHHHHHCCCCCTTSCTT-------CHHHHHHHCCCCCTTTTSSCHHHHHHHHHSS-CCCSHHH T ss_pred Hccchh-HHHHH-HHHHHHHHHHHHHHHHhcCCC-------CHHHHHHHHHHhhhcCCCCCHHHHHHHHhCC-CCCHHHH Confidence 766653 44421 22211111111 112222332 3689999999 99999999999999999994 7999999 Q sp|Q9BYF1|ACE2 585 LNYFE 589 (805) Q Consensus 585 lnyfe 589 (805) +.++. T Consensus 678 l~~~~ 682 (686) T 5LV0_A 678 LMSRG 682 (686) T ss_dssp HHHHT T ss_pred HHHcC Confidence 88864 No 29 >1S4B_P Thimet oligopeptidase (E.C.3.4.24.15); Zinc metallopeptidase domain, HYDROLASE; 2.0A {Homo sapiens} SCOP: d.92.1.5 Probab=99.88 E-value=1.6e-27 Score=236.83 Aligned_cols=516 Identities=16% Similarity=0.187 Sum_probs=326.3 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 26 KTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPL-------------QEIQNLT 92 (805) Q Consensus 26 ktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmypl-------------qeiqnlt 92 (805) +..+..+......+-...+.+.|.++++.+++..+....+-.++++|..+..+-...|.+ .+.+... T Consensus 47 ~~~i~~~d~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~ld~e~~r~ 126 (674) T 1S4B_P 47 ESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARY 126 (674) T ss_pred HHhHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHcCCHHHHHHHHHHHhCcchhhCCHHHHHH Confidence 344556666666677888899999999999999999999999999999887666666652 2222333 Q sp|Q9BYF1|ACE2 93 VKLQLQALQQNGSSVLSEDKSKRLNTIL---NTMSTIYSTGKVCNPDN------------------------PQECLLLE 145 (805) Q Consensus 93 vklqlqalqqngssvlsedkskrlntil---ntmstiystgkvcnpdn------------------------pqecllle 145 (805) ++..+..++.+|.. |++++.+++..+. ..++..|.....|.... ...++.+. T Consensus 127 l~~~l~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~~~~~l~ 205 (674) T 1S4B_P 127 LERLIKLGRRNGLH-LPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLK 205 (674) T ss_pred HHHHHHHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHhccccccccEEeHHHHcCCCHHHHHHHHHHHcCCeEEEcC Confidence 45555666777754 6666656665554 44677777777665321 11234444 Q sp|Q9BYF1|ACE2 146 -PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIE 224 (805) Q Consensus 146 -pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqlie 224 (805) |.+..+|+++-|...|-.+|+.|+...++...+++++.+.+++++|+...|.+|.+||..++.+. +..++.+ T Consensus 206 ~~~~~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~l~~lR~~~A~~lGy~s~~~~~l~~~~~~-------~~~~v~~ 278 (674) T 1S4B_P 206 YPHYFPLLKKCHVPETRRKVEEAFNSRCKEENSAILKELVTLRAQKSRLLGFHTHADYVLEMNMAK-------TSQTVAT 278 (674) T ss_pred CccHHHHHhcCCCHHHHHHHHHHHHccCCcccHHHHHHHHHHHHHHHHHhCCCCHHHHHccccCCC-------CHHHHHH Confidence 67899999999999999999999987777889999999999999999999999999998765442 2223333 Q sp|Q9BYF1|ACE2 225 DVEHTFEEIKPLYEHLHAYVRAKLM---NAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQA 301 (805) Q Consensus 225 dvehtfeeikplyehlhayvraklm---naypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqa 301 (805) -.+...+.++|+|+..+++++.... +.+.. +..+-+ ..|...|-...+... ...+..+.+... T Consensus 279 ~l~~l~~~~~p~~~~~~~~l~~~~~~~~~~~g~--~~~~~l----------~~wD~~y~~~~~~~~--~~~~~~~~i~~y 344 (674) T 1S4B_P 279 FLDELAQKLKPLGEQERAVILELKRAECERRGL--PFDGRI----------RAWDMRYYMNQVEET--RYCVDQNLLKEY 344 (674) T ss_pred HHHHHHHHhHHHHHHHHHHHHHHHHHHHHhcCC--CCCCCC----------ChhcHHHHHHHHHHh--cCCCCHHHHHhh Confidence 3445567889999999888775322 22210 001111 234444444333211 223333333332 Q sp|Q9BYF1|ACE2 302 WD----AQRIFKEAEKFFVSVGLPN---MTQGFWENSML-----------------TD----PGNVQKAVCHPTAWDL-- 351 (805) Q Consensus 302 wd----aqrifkeaekffvsvglpn---mtqgfwensml-----------------td----pgnvqkavchptawdl-- 351 (805) .. ...+++.++++| |+.. ....+|.++.. .| ||.-..+.|.+...+. T Consensus 345 f~~~~~~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~d~~~~~~lg~~~lD~~~r~~K~~~a~~~~~~~~~~~ 421 (674) T 1S4B_P 345 FPVQVVTHGLLGIYQELL---GLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLR 421 (674) T ss_pred CCHHHHHHHHHHHHHHHh---CCEEEECCCCCcccCCceEEEEEeCCCCcEEEEEEEECCCCCCCCCCcceeeEecCccC Confidence 21 245666666666 4322 24456777654 22 2222234444332211 Q sp|Q9BYF1|ACE2 352 --GKGD--FRIL----------MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGAN--EGFHEAVGEIMSLSAATP 415 (805) Q Consensus 352 --gkgd--fril----------mctkvtmddfltahhemghiqydmayaaqpfllrngan--egfheavgeimslsaatp 415 (805) |+.. ..++ .|+.++.+|+.|.+||+||..+.+.+..++. ...|++ -.|+|+.+.+|...+..| T Consensus 422 ~~~~~~~p~~~l~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~-~~~g~~~~~d~~E~~S~~~E~~~~~~ 500 (674) T 1S4B_P 422 QDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFA-MFSGTHVERDFVEAPSQMLENWVWEQ 500 (674) T ss_pred CCCCeeccEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhCCCch-hhcCCCCCCcccccchHHHHHhhcCH Confidence 1000 0122 6778889999999999999999998876544 456655 799999999999999999 Q sp|Q9BYF1|ACE2 416 KHLKSIGLLSPDFQEDNETEINFLLKQA-----LTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEP 490 (805) Q Consensus 416 khlksigllspdfqedneteinfllkqa-----ltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep 490 (805) ++|+.++.-..+-+.-.+..++.+++.. +.++..+.+ ..++.+ ++.+. ..++.+.||++..+..|+ | T Consensus 501 ~~L~~l~~~~~~~~~l~~~~~~~l~~~~~~~~~l~~~~~l~~-~~~d~~---l~~~~--~~~~~~~~~~l~~~~~g~--~ 572 (674) T 1S4B_P 501 EPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVL-AKVDQA---LHTQT--DADPAEEYARLCQEILGV--P 572 (674) T ss_pred HHHHHHhhccCCCCCCCHHHHHHHHHhhcHHHHHHHHHHHHH-HHHHHH---HhcCC--CCcHHHHHHHHHHHHcCC--C Confidence 9999887543221111233455554322 222222222 222322 23222 256788899999998887 3 Q sp|Q9BYF1|ACE2 491 VPHDETYCDPASLFHVSNDYSF--IRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWT 567 (805) Q Consensus 491 vphdetycdpaslfhvsndysf--iryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwt 567 (805) .+.+ ...+.+..|...+|.+ ..|....+..+++-.+.| +..||+ +.++|.++. ++|..|.+.+|. T Consensus 573 ~~~~--~~~~~~~~h~~~~y~~~yysYl~s~v~A~~i~~~~~---~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~ 640 (674) T 1S4B_P 573 ATPG--TNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRF---KQEGVL-------NSKVGMDYRSCILRPGGSEDAS 640 (674) T ss_pred CCCC--CCchhhhHHHHccchHHHHHHHHHHHHHHHHHHHHH---hhhCCC-------CHHHHHHHHHHhcccCCCCCHH Confidence 3222 3466778888755544 333333333444322222 223443 358899998 899999999999 Q sp|Q9BYF1|ACE2 568 LALENVVGAKNMNVRPLLNYF 588 (805) Q Consensus 568 lalenvvgaknmnvrpllnyf 588 (805) -.++++.| .+++..+++.++ T Consensus 641 e~l~~~lG-~~~~~~~~l~~~ 660 (674) T 1S4B_P 641 AMLRRFLG-RDPKQDAFLLSK 660 (674) T ss_pred HHHHHHhC-CCCCHHHHHHHc Confidence 99999988 568888887665 No 30 >5L44_A K-26 dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, metalloprotease, K-26 tripeptide; HET: K26, SO4; 1.75A {Astrosporangium hypotensionis K-26} Probab=99.77 E-value=4.9e-23 Score=205.45 Aligned_cols=512 Identities=16% Similarity=0.122 Sum_probs=318.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 28 FLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---------LQEIQNLTVKLQLQ 98 (805) Q Consensus 28 fldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---------lqeiqnltvklqlq 98 (805) ++..+..-...+..-.+++++.+.++.+++..+..+.+..+.+.+..+.......|. +.+-+...++..++ T Consensus 76 ~i~~le~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~l~~e~~~~l~~~l~ 155 (683) T 5L44_A 76 TVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHGDAIHLNRPLFARIKQISPDGLDAEQAWLLERYVT 155 (683) T ss_dssp CCCHHHHCCHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHTCCCTTCCHHHHHHHHHHHH T ss_pred HHHHHHHhhHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHcccCCCHHHHHHHHHHHH Confidence 344444444555556778888888887888888888888888888766655444443 22223445556677 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSED--KSKRLNTILNTMSTIYS----TGK----VCN---------PDN--------------PQ-ECLLL 144 (805) Q Consensus 99 alqqngssvlsed--kskrlntilntmstiys----tgk----vcn---------pdn--------------pq-eclll 144 (805) .+.++|...++++ +-..++..+..++..|+ +.+ +|- |.. +. .++-+ T Consensus 156 ~~~~~G~~l~~~~~e~~~~l~~~~~~l~~~f~~n~~~~~~~~~~~~~~~~~l~glp~~~~~~~~~~~~~~~~~G~~~i~l 235 (683) T 5L44_A 156 DFVRAGAELGAGDQERLKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAETAKSRGLPGKYVIPL 235 (683) T ss_dssp HHHHTTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCEEESCGGGGTTSCHHHHHHHHHHHHHTTCTTSEEECC T ss_pred HHHHhcccCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccceecCCHHHHCCCCHHHHHHHHHHHHHcCCCCCeEEec Confidence 7888888877765 34445666777778887 332 332 110 11 23444 Q sp|Q9BYF1|ACE2 145 E-PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 e-pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) . |....+|.++-|...|-.+|++|.....+...+++++.+-+++++|+...|++|.+||-.++.+... T Consensus 236 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~n~~~l~~lv~~R~~~A~~lGy~s~a~~~l~~~~~~~~----------- 304 (683) T 5L44_A 236 VLPTGQPGLAELTDRALRERIHRASIQRGVPDNEELIVRIATLRAERAKLLGYPTHAAYVVADQTAPTT----------- 304 (683) T ss_dssp CSSSSCGGGGTCCCHHHHHHHHHHHHTTTTTTTHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSSCCH----------- T ss_pred CCCchHHHHHhCCCHHHHHHHHHHHHhcCCcchHHHHHHHHHHHHHHHHHhCCCCHHHHHcCCCCCCCH----------- Confidence 4 6788899999999999999999997655678899999999999999999999999999877665421 Q sp|Q9BYF1|ACE2 224 EDVEHTFEE-IKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAW 302 (805) Q Consensus 224 edvehtfee-ikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqaw 302 (805) ++|.....+ +++++..+|++++.+... + |+ --..|.-.|-....... .+.+..+.+..-. T Consensus 305 ~~v~~~L~~l~~~~~p~~~~~~~~l~~~-~---------------~~-~l~~wD~~y~~~~~~~~--~~~~~~~~~~~yf 365 (683) T 5L44_A 305 EAVTEMLGKLTPPAVANAHREADELREQ-A---------------GH-DLEPWDWSFYAEKVLKE--RYAIDGRQMRPYF 365 (683) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHH-H---------------SS-CCCGGGHHHHHHHHHHH--HHCCCHHHHGGGC T ss_pred HHHHHHHHHhhHHhHHHHHHHHHHHHHH-c---------------CC-CCCccCHHHHHHHHHHH--hhCCChhHhHhhc Confidence 223222222 346666778887754321 1 11 01223332322211111 1111111111111 Q sp|Q9BYF1|ACE2 303 DAQ-----RIFKEAEKFF--------------------VSVGL-PNMTQGFWENSMLTDPGNVQKAVCHPTAWD--LGKG 354 (805) Q Consensus 303 daq-----rifkeaekff--------------------vsvgl-pnmtqgfwensmltdpgnvqkavchptawd--lgkg 354 (805) ... .+|.-++++| .-.+- ......+|-. ....+|....+.|++..-. .... T Consensus 366 ~~~~v~~~~l~~~~~~lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~lg~~~lD-~~~r~~K~~~~~~~~~~~~~~~~~~ 444 (683) T 5L44_A 366 ELDRVLRDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGD-YYARPSKRGGAWMNSLVKQSTLEGT 444 (683) T ss_dssp BHHHHCCCCCCHHHHHHHCCEEEECTTSCCSSTTCEEEEEECTTSCEEEEEEEE-EECCTTSCSSCEEEEEECCBTTTTB T ss_pred CHHHHHHHHHHHHHHHHhCCEEEECCCCCCccCCeEEEEEEcCCCCEEEEEEEe-ccCCCCCCCCccccccccccccCCC Confidence 111 1222222221 00000 0111113322 1223344444566653210 0134 Q sp|Q9BYF1|ACE2 355 DFRILMCTK-----------VTMDDFLTAHHEMGHIQYDMAYA-AQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIG 422 (805) Q Consensus 355 dfrilmctk-----------vtmddfltahhemghiqydmaya-aqpfllrnganegfheavgeimslsaatpkhlksig 422 (805) ...|.+|.. .+.+|+.|.+||+||..+.+... .+|.+.+.+....|.|+.+.+|.+-+..|.+|++++ T Consensus 445 ~p~v~l~~~~~~~~~~~~~l~~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~~~ 524 (683) T 5L44_A 445 RPVVVNNLNIAKPPAGEPTLMTFEEVNTMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLANYA 524 (683) T ss_dssp CCEEEEEEEECCCCTTCCCBCCHHHHHHHHHHHHHHHHHHTCCCSSGGGCTTCSCHHHHHHHHHHHTHHHHCHHHHHHHC T ss_pred CCEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHcCCCCccccCCCCCchhhccchHHhHhhhcCHHHHHHHh Confidence 577888887 89999999999999999988765 577777777889999999999999999999999987 Q sp|Q9BYF1|ACE2 423 LLSPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 423 llspdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) ....+-+.-.+..++.++. +++.++..+++. .++.+ ++.+..+.+.+..-||+...+. |+.-|... . . T Consensus 525 ~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~D~~---lh~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~-~ 597 (683) T 5L44_A 525 RHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAAT-LLDWS---WHTFQTPPENALTFEHEALTTA-GVDLKLVP-P-R 597 (683) T ss_dssp BCTTTCCBCCHHHHHHHHHTTSTTHHHHHHHHHHHH-HHHHH---HTSCSSCCSCHHHHHHHHHHHT-TCCBTTBC-C-S T ss_pred hccCCCCCCCHHHHHHHHHhhchhHHHHHHHHHHHH-HHHHH---HhcCCCCCccHHHHHHHHHHHh-CCCCCCCC-C-c Confidence 6643222224455666654 567777777775 66655 3444444466777788866665 76544321 1 2 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENV 573 (805) Q Consensus 498 cdpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenv 573 (805) ..+.+..|+.. +|. +..|....+..++.-+++|++ ||+ +.++|+++. .+|+.|.+.||.-.++.. T Consensus 598 ~~~~~~~hi~~~~y~~~yy~Yl~s~v~a~~i~~~f~~~----~~~-------~~~~g~~~r~~iL~~G~s~~~~e~l~~f 666 (683) T 5L44_A 598 YRSTYFAHIWSSGYSAGYYSYIWSEVLDADTVDWFHEN----GGL-------LRENGDTFRQKLLSKGGSVDPMTAFQSF 666 (683) T ss_dssp SCGGGCHHHHTSSCTTCTTHHHHHHHHHHHHHHHHHHT----TSS-------CHHHHHHHCCCCCTCTTSSCHHHHHHHH T ss_pred ccccccHhHhcCCchHHHHHHHHHHHHHHHHHHHHHHc----CCC-------cHHHHHHHHHHHHHcCCCCCHHHHHHHH Confidence 23677777654 443 335555555666666665543 444 358899999 999999999999999999 Q sp|Q9BYF1|ACE2 574 VGAKNMNVRPLLNYFE 589 (805) Q Consensus 574 vgaknmnvrpllnyfe 589 (805) .|.. .+..+++.|+. T Consensus 667 ~G~~-~s~~~~l~~~~ 681 (683) T 5L44_A 667 RGRT-PRIEPLLDRRG 681 (683) T ss_dssp HSSS-CCSHHHHHHHT T ss_pred hCCC-CChHHHHHHcC Confidence 9986 88888888764 No 31 >5L43_B K-26 dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, metalloprotease, K-26 tripeptide; HET: SO4; 1.8A {Astrosporangium hypotensionis K-26} Probab=99.77 E-value=4.9e-23 Score=205.45 Aligned_cols=512 Identities=16% Similarity=0.122 Sum_probs=318.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 28 FLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---------LQEIQNLTVKLQLQ 98 (805) Q Consensus 28 fldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---------lqeiqnltvklqlq 98 (805) ++..+..-...+..-.+++++.+.++.+++..+..+.+..+.+.+..+.......|. +.+-+...++..++ T Consensus 76 ~i~~le~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~l~~e~~~~l~~~l~ 155 (683) T 5L43_B 76 TVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHGDAIHLNRPLFARIKQISPDGLDAEQAWLLERYVT 155 (683) T ss_dssp CCCHHHHCCHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHTCCSTTCCHHHHHHHHHHHH T ss_pred HHHHHHHhhHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHcccCCCHHHHHHHHHHHH Confidence 344444444555556778888888887888888888888888888766655444443 22223445556677 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSED--KSKRLNTILNTMSTIYS----TGK----VCN---------PDN--------------PQ-ECLLL 144 (805) Q Consensus 99 alqqngssvlsed--kskrlntilntmstiys----tgk----vcn---------pdn--------------pq-eclll 144 (805) .+.++|...++++ +-..++..+..++..|+ +.+ +|- |.. +. .++-+ T Consensus 156 ~~~~~G~~l~~~~~e~~~~l~~~~~~l~~~f~~n~~~~~~~~~~~~~~~~~l~glp~~~~~~~~~~~~~~~~~G~~~i~l 235 (683) T 5L43_B 156 DFVRAGAELGAGDQERLKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAETAKSRGLPGKYVIPL 235 (683) T ss_dssp HHHHTTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCEEESCGGGGTTSCHHHHHHHHHHHHHTTCTTSEEECC T ss_pred HHHHhcccCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccceecCCHHHHCCCCHHHHHHHHHHHHHcCCCCCeEEec Confidence 7888888877765 34445666777778887 332 332 110 11 23444 Q sp|Q9BYF1|ACE2 145 E-PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 e-pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) . |....+|.++-|...|-.+|++|.....+...+++++.+-+++++|+...|++|.+||-.++.+... T Consensus 236 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~n~~~l~~lv~~R~~~A~~lGy~s~a~~~l~~~~~~~~----------- 304 (683) T 5L43_B 236 VLPTGQPGLAELTDRALRERIHRASIQRGVPDNEELIVRIATLRAERAKLLGYPTHAAYVVADQTAPTT----------- 304 (683) T ss_dssp CSSSSCGGGGTCCCHHHHHHHHHHHHTTTTTTTHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSSCCH----------- T ss_pred CCCchHHHHHhCCCHHHHHHHHHHHHhcCCcchHHHHHHHHHHHHHHHHHhCCCCHHHHHcCCCCCCCH----------- Confidence 4 6788899999999999999999997655678899999999999999999999999999877665421 Q sp|Q9BYF1|ACE2 224 EDVEHTFEE-IKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAW 302 (805) Q Consensus 224 edvehtfee-ikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqaw 302 (805) ++|.....+ +++++..+|++++.+... + |+ --..|.-.|-....... .+.+..+.+..-. T Consensus 305 ~~v~~~L~~l~~~~~p~~~~~~~~l~~~-~---------------~~-~l~~wD~~y~~~~~~~~--~~~~~~~~~~~yf 365 (683) T 5L43_B 305 EAVTEMLGKLTPPAVANAHREADELREQ-A---------------GH-DLEPWDWSFYAEKVLKE--RYAIDGRQMRPYF 365 (683) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHH-H---------------TS-CCCGGGHHHHHHHHHHH--HHCCCHHHHGGGC T ss_pred HHHHHHHHHhhHHhHHHHHHHHHHHHHH-c---------------CC-CCCccCHHHHHHHHHHH--hhCCChhHhHhhc Confidence 223222222 346666778887754321 1 11 01223332322211111 1111111111111 Q sp|Q9BYF1|ACE2 303 DAQ-----RIFKEAEKFF--------------------VSVGL-PNMTQGFWENSMLTDPGNVQKAVCHPTAWD--LGKG 354 (805) Q Consensus 303 daq-----rifkeaekff--------------------vsvgl-pnmtqgfwensmltdpgnvqkavchptawd--lgkg 354 (805) ... .+|.-++++| .-.+- ......+|-. ....+|....+.|++..-. .... T Consensus 366 ~~~~v~~~~l~~~~~~lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~lg~~~lD-~~~r~~K~~~~~~~~~~~~~~~~~~ 444 (683) T 5L43_B 366 ELDRVLRDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGD-YYARPSKRGGAWMNSLVKQSTLEGT 444 (683) T ss_dssp BHHHHCCCCCHHHHHHHHCCEEEECTTSCCSSTTCEEEEEECTTSCEEEEEEEE-EECCTTSCSSCEEEEEECCBTTTTB T ss_pred CHHHHHHHHHHHHHHHHhCCEEEECCCCCCccCCeEEEEEEcCCCCEEEEEEEe-ccCCCCCCCCccccccccccccCCC Confidence 111 1222222221 00000 0111113322 1223344444566653210 0134 Q sp|Q9BYF1|ACE2 355 DFRILMCTK-----------VTMDDFLTAHHEMGHIQYDMAYA-AQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIG 422 (805) Q Consensus 355 dfrilmctk-----------vtmddfltahhemghiqydmaya-aqpfllrnganegfheavgeimslsaatpkhlksig 422 (805) ...|.+|.. .+.+|+.|.+||+||..+.+... .+|.+.+.+....|.|+.+.+|.+-+..|.+|++++ T Consensus 445 ~p~v~l~~~~~~~~~~~~~l~~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~~~ 524 (683) T 5L43_B 445 RPVVVNNLNIAKPPAGEPTLMTFEEVNTMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLANYA 524 (683) T ss_dssp CCEEEEEEEECCCCTTCCCBCCHHHHHHHHHHHHHHHHHHTCCCSSGGGCTTCSCHHHHHHHHHHHTHHHHCHHHHHHHC T ss_pred CCEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHcCCCCccccCCCCCchhhccchHHhHhhhcCHHHHHHHh Confidence 577888887 89999999999999999988765 577777777889999999999999999999999987 Q sp|Q9BYF1|ACE2 423 LLSPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 423 llspdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) ....+-+.-.+..++.++. +++.++..+++. .++.+ ++.+..+.+.+..-||+...+. |+.-|... . . T Consensus 525 ~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~D~~---lh~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~-~ 597 (683) T 5L43_B 525 RHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAAT-LLDWS---WHTFQTPPENALTFEHEALTTA-GVDLKLVP-P-R 597 (683) T ss_dssp BCTTTCCBCCHHHHHHHHHTTSTTHHHHHHHHHHHH-HHHHH---HTTCSSCCSCHHHHHHHHHHHT-TCCBTTBC-C-S T ss_pred hccCCCCCCCHHHHHHHHHhhchhHHHHHHHHHHHH-HHHHH---HhcCCCCCccHHHHHHHHHHHh-CCCCCCCC-C-c Confidence 6643222224455666654 567777777775 66655 3444444466777788866665 76544321 1 2 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENV 573 (805) Q Consensus 498 cdpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenv 573 (805) ..+.+..|+.. +|. +..|....+..++.-+++|++ ||+ +.++|+++. .+|+.|.+.||.-.++.. T Consensus 598 ~~~~~~~hi~~~~y~~~yy~Yl~s~v~a~~i~~~f~~~----~~~-------~~~~g~~~r~~iL~~G~s~~~~e~l~~f 666 (683) T 5L43_B 598 YRSTYFAHIWSSGYSAGYYSYIWSEVLDADTVDWFHEN----GGL-------LRENGDTFRQKLLSKGGSVDPMTAFQSF 666 (683) T ss_dssp SCGGGCHHHHTSSCTTCTTHHHHHHHHHHHHHHHHHHT----TSS-------CHHHHHHHCCCCCTCTTSSCHHHHHHHH T ss_pred ccccccHhHhcCCchHHHHHHHHHHHHHHHHHHHHHHc----CCC-------cHHHHHHHHHHHHHcCCCCCHHHHHHHH Confidence 23677777654 443 335555555666666665543 444 358899999 999999999999999999 Q sp|Q9BYF1|ACE2 574 VGAKNMNVRPLLNYFE 589 (805) Q Consensus 574 vgaknmnvrpllnyfe 589 (805) .|.. .+..+++.|+. T Consensus 667 ~G~~-~s~~~~l~~~~ 681 (683) T 5L43_B 667 RGRT-PRIEPLLDRRG 681 (683) T ss_dssp HSSS-CCSHHHHHHHT T ss_pred hCCC-CChHHHHHHcC Confidence 9986 88888888764 No 32 >1Y79_1 Peptidyl-Dipeptidase Dcp (E.C.3.4.15.5); hinge bending peptidyl dipeptidase; HET: TRP; 2.0A {Escherichia coli} Probab=99.44 E-value=4.5e-17 Score=163.19 Aligned_cols=501 Identities=14% Similarity=0.139 Sum_probs=281.7 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 41 YQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-------------PLQEIQNLTVKLQLQALQQNGSSV 107 (805) Q Consensus 41 yqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-------------plqeiqnltvklqlqalqqngssv 107 (805) .-.+.+++-+.++.+++.-..-..+..+.+++..+..+=..+| .+.+-+...++..++....+|... T Consensus 70 ~~~~~~~~l~~~~~~~e~r~a~~~~~~~~~~~~~~~~~~~~ly~~l~~~~~~~~~~~l~~e~~r~l~~~l~~~~~~G~~L 149 (680) T 1Y79_1 70 RVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKL 149 (680) T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHccCHHHHHHHHHHHcCCCccCCCHHHHHHHHHHHHHHHHcCCCC Confidence 3455666667777555554445555555665544432111111 122223334555666677788765 Q sp|Q9BYF1|ACE2 108 LSEDKSKRLNTILNT---MSTIYSTGKVC---------N--------PD----------------NPQECLLLEPGLNEI 151 (805) Q Consensus 108 lsedkskrlntilnt---mstiystgkvc---------n--------pd----------------npqeclllepglnei 151 (805) .++ +.+|+..+... +++.|+..-.. . |+ .+...-+-.|.+..+ T Consensus 150 ~~~-~~~~l~~l~~~i~~l~~~f~~n~~~~~~~~~~~~~~~~~L~g~p~~~l~~~~~~a~~~~~~~~~~i~l~~~~~~~~ 228 (680) T 1Y79_1 150 AQA-DKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPA 228 (680) T ss_pred CHH-HHHHHHHHHHHHHHHHHHHHHhcccccccccccCCCHHHHcCCCHHHHHHHHHHHHHcCCCCCeEeeCCCccHHHH Confidence 444 44666655443 22223211110 0 00 111122223567888 Q sp|Q9BYF1|ACE2 152 MANSLDYNERLWAWESWRSEVG----KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVE 227 (805) Q Consensus 152 mansldynerlwaweswrsevg----kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedve 227 (805) |+++-|...|--+|..|.+... ....+++.+.+.+++++|+...|++|.+|+-.+.. ..+..++.+-.. T Consensus 229 l~~~~d~~~R~~~~~a~~~~~~~~~~~~~~~~l~~lv~~R~~~A~llGy~s~~~~~l~~~m-------~~~~~~v~~~L~ 301 (680) T 1Y79_1 229 LAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQM-------AKTPEAALNFMR 301 (680) T ss_pred HHhCCCHHHHHHHHHHHHhccccCCccccHHHHHHHHHHHHHHHHHhCCCCHHHHHhcccC-------CCCHHHHHHHHH Confidence 9999999999999999975543 46789999999999999999999999999864431 223334444455 Q sp|Q9BYF1|ACE2 228 HTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQR- 306 (805) Q Consensus 228 htfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqr- 306 (805) ...+.++|++++.++.+++.....+ |+--...|...|-...+-. ...+++++.+.+-....+ T Consensus 302 ~l~~~~~p~~~~e~~~l~~~~~~~~---------------g~~~l~~wD~~y~~~~~~~--~~~~~~~~~~~~yf~~~~v 364 (680) T 1Y79_1 302 EIVPAARQRASDELASIQAVIDKQQ---------------GGFSAQPWDWAFYAEQVRR--EKFDLDEAQLKPYFELNTV 364 (680) T ss_pred HHHHHhHHHHHHHHHHHHHHHHHhc---------------CCCCCCcccHHHHHHhHHh--hccCCCHHHHHhhCCHHHH Confidence 5567888999988888887554322 1111233433333222211 223343444433333332 Q sp|Q9BYF1|ACE2 307 ----IFKEAEKFFVSVGLPN---MTQGFWENSM----------------LTDP----GNVQKAVCHPTAWD--LGKGDFR 357 (805) Q Consensus 307 ----ifkeaekffvsvglpn---mtqgfwensm----------------ltdp----gnvqkavchptawd--lgkgdfr 357 (805) +|+.+++.| |+-- ....+|..+. .-|+ |.-..+-|.+..-. ....+.+ T Consensus 365 ~~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~~~~~~~lg~~y~D~~~r~~K~~~~~~~~~~~~~~~~~~~p~ 441 (680) T 1Y79_1 365 LNEGVFWTANQLF---GIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPV 441 (680) T ss_pred HHHhHHHHHHHHh---CCEEEEcCCCccccCCceEEEEEcCCCCEEEEEEEeCCCCCCCCCCCcccceecccCCCCCCCE Confidence 444555544 2111 0111233322 1121 22222223221000 0012344 Q sp|Q9BYF1|ACE2 358 I-----------LMCTKVTMDDFLTAHHEMGHIQYDMAYAAQ-PFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLS 425 (805) Q Consensus 358 i-----------lmctkvtmddfltahhemghiqydmayaaq-pfllrnganegfheavgeimslsaatpkhlksiglls 425 (805) | -.|+.++.+|+.|.+||+||..+.+..... +.+...+..-.|.|+.+.+|..-+..|..|+.++.-- T Consensus 442 v~~~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~l~~~~~~~ 521 (680) T 1Y79_1 442 IYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHY 521 (680) T ss_pred EEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhCCCCchhcCCCCcccccccchHhhHHHhcCHHHHHHHhhcC Confidence 4 267778899999999999999998776543 2222344678899999999999999999999876432 Q sp|Q9BYF1|ACE2 426 PDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGE--IPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 426 pdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkge--ipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) .+-+.-.+..++.|++ +++.++..+.+ ..++.+-+-...++ +..+++ .||+...+-.|+ .+.+ ..+. T Consensus 522 ~~~~~l~~~~~~~l~~~~~~~~~~~~~~~l~~-~~~D~~lh~~~~~~~~~~~~~~--~~~~~~~~~~~~-~~~~--~~~~ 595 (680) T 1Y79_1 522 QSGAAMPDELQQKMRNASLFNKGYEMSELLSA-ALLDMRWHCLEENEAMQDVDDF--ELRALVAENMDL-PAIP--PRYR 595 (680) T ss_pred CCCCCCCHHHHHHHHHHhhHHHHHHHHHHHHH-HHHHHHHhcCCCCCCCCChhHH--HHHHHHHHHHCC-CCCC--CCcc Confidence 1111112334555543 35555555544 46666555444332 333444 455544434465 2222 2333 Q sp|Q9BYF1|ACE2 499 DPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENVV 574 (805) Q Consensus 499 dpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenvv 574 (805) +.+..|+.. +|. +..|....++.+++.+.+|+ +|++ +.++|+++. .+|..|.+.++.-.++... T Consensus 596 -~~~~~hi~~~~y~~~yysY~~s~v~a~~i~~~~~~----~~~~-------~~~~g~~~r~~~L~~G~s~~~~e~~~~fl 663 (680) T 1Y79_1 596 -SSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVE----QGGL-------TRENGLRFREAILSRGNSEDLERLYRQWR 663 (680) T ss_pred -ccccHHHHcCCcchHHHHHHHHHHHHHHHHHHHHH----hCCC-------CHHHHHHHHHHhhccCCCCCHHHHHHHHh Confidence 677777753 333 23444455555565555544 3443 257899998 8999999999999999998 Q sp|Q9BYF1|ACE2 575 GAKNMNVRPLLNYF 588 (805) Q Consensus 575 gaknmnvrpllnyf 588 (805) |.. .+..+++.++ T Consensus 664 G~~-~~~~~~l~~~ 676 (680) T 1Y79_1 664 GKA-PKIMPMLQHR 676 (680) T ss_pred CCC-CCHHHHHHHc Confidence 876 7777777765 No 33 >4KA7_A Oligopeptidase A, short endogenous peptide; Protease, Mitochondria, chloroplast, HYDROLASE-HYDROLASE SUBSTRATE; HET: GOL; 1.8A {Arabidopsis thaliana} Probab=99.43 E-value=5.8e-17 Score=163.74 Aligned_cols=407 Identities=15% Similarity=0.103 Sum_probs=238.2 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 144 LEPGLNEIMANSLDYNERLWAWESWRSEVG---KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220 (805) Q Consensus 144 lepglneimansldynerlwaweswrsevg---kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrg 220 (805) -.|.+..+|.++-|...|--+|++|.+..+ ....+++.+.+.+++++|+...|++|.+|+-.+..+ +.. T Consensus 239 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~~~~~~~~l~~l~~~R~~~A~llGy~s~a~~~l~~~~~--------~~~ 310 (714) T 4KA7_A 239 DAPSYLPVMQHAKNRALREEVYRAYLSRASSGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA--------TVE 310 (714) T ss_dssp SHHHHHHHHHHCCCHHHHHHHHHHHHTTTCSGGGCCHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSC--------CHH T ss_pred CCccHHHHHHhCCCHHHHHHHHHHHHcccCCCCcChHHHHHHHHHHHHHHHHHhCCCCHHHHHHHHhcC--------CHH Confidence 346678899999899999999999987654 568899999999999999999999999998654333 222 Q sp|Q9BYF1|ACE2 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK-PNIDVTDAMVD 299 (805) Q Consensus 221 qliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqk-pnidvtdamvd 299 (805) .+.+-++...+.++|+++..++.++......+. . |.---..|...|-.. ++-+. .+++ ...+. T Consensus 311 ~v~~~L~~l~~~~~~~~~~~~~~l~~~~~~~~~--------~-----~~~~l~~wD~~y~~~-~~~~~~~~~~--~~~~~ 374 (714) T 4KA7_A 311 KAAELLEKLRSASWDAAVQDMEDLKSFAKNQGA--------A-----ESDSMTHWDTTFWSE-RLRESKYDIN--EEELR 374 (714) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC--------G-----GGGSCCTTTHHHHHH-HHHHHHHCCC--HHHHG T ss_pred HHHHHHHHHHHhcHHHHHHHHHHHHHHHHHcCC--------C-----CCCCCCcccHHHHHH-HHHHhcCCCC--HHHHH Confidence 333444445556677777666666643222111 0 000012333332222 11111 1111 11111 Q sp|Q9BYF1|ACE2 300 QAWD----AQRIFKEAEKFFVSVGLPNMT--QGFWENSM----------------LTDP----G-NVQKAVCHPTAWD-- 350 (805) Q Consensus 300 qawd----aqrifkeaekffvsvglpnmt--qgfwensm----------------ltdp----g-nvqkavchptawd-- 350 (805) .-.. ...+|+-++++|- +++.... ...|..+. .-|+ | ....+.|++..-. T Consensus 375 ~yf~~~~~~~~i~~~~~~~f~-l~~~~~~~~~~~w~~~v~~~~v~~~~~~~~g~~~lD~~~r~~kk~~g~~~~~~~~~~~ 453 (714) T 4KA7_A 375 PYFSLPKVMDGLFSLAKTLFG-IDIEPADGLAPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSEKRGGAWMDEVVSRSR 453 (714) T ss_dssp GGCBHHHHHHHHHHHHHHHHC-CEEEECTTSSCCSSTTCEEEEEECTTSCEEEEEEEEEECCTTTSCSSCEEEEEECCBS T ss_pred hcCCHHHHHHHHHHHHHHHHC-cEEEECCCCCCcccCCcEEEEEEcCCCCeEEEEEECCCCCCCCCCCCcccccccccch Confidence 1111 2345555566655 4444332 12343322 1222 2 1222334322110 Q sp|Q9BYF1|ACE2 351 -LG-----KGDFRILMC-----------TKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR--NGANEGFHEAVGEIMSLS 411 (805) Q Consensus 351 -lg-----kgdfrilmc-----------tkvtmddfltahhemghiqydmayaaqpfllr--nganegfheavgeimsls 411 (805) ++ .....|+|+ +.++.+|+.|.+||+||..+.+....+...+. .+..-.|.|+.+.+|..- T Consensus 454 ~~~~~~~~~~~p~v~~~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~~g~~~~~~d~~E~~S~~~E~~ 533 (714) T 4KA7_A 454 VMAQKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHQFGHALQHMLTKQDEGLVAGIRNIEWDAVELPSQFMENW 533 (714) T ss_dssp TTCCTTSSCBCCEEEEEEEECCCCTTSCCBCCHHHHHHHHHHHHHHHHHHSCCCCCGGGSTTTTCCGGGTTHHHHHHHGG T ss_pred hHhcCCCceeccEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHhhCCCchhhcCccccccccchhcHHHHHHH Confidence 00 123456654 44569999999999999999887765554444 256889999999999999 Q sp|Q9BYF1|ACE2 412 AATPKHLKSIGLLSPDFQEDNETEINFLLKQ-----ALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVG 486 (805) Q Consensus 412 aatpkhlksigllspdfqedneteinfllkq-----altivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivg 486 (805) +..|..|+.++.-..+-++..+..++.+++. ++.++. .++-..++.+.+-...+.-| ..+-+-|+++..+. | T Consensus 534 ~~~~~~L~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~-~~~~~~~D~~lh~~~~~~~~-~~~~~~~~~~~~~~-~ 610 (714) T 4KA7_A 534 CYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLR-QLKFASVDLELHTKYVPGGP-ESIYDVDQRVSVKT-Q 610 (714) T ss_dssp GGSHHHHHHHCBCTTTCCBCCHHHHHHHHHTTTTTHHHHHHH-HHHHHHHHHHHTTTCCTTSS-CCHHHHHHHHHHHH-C T ss_pred hcCHHHHHHHhhccCCCCCCCHHHHHHHHHHhhhchHHHHHH-HHHHHHHHHHHHhcCCCCCC-CCHHHHHHHHHHHh-C Confidence 9999999887653322222233446666654 555544 55667788877776643323 23335577664444 3 Q sp|Q9BYF1|ACE2 487 VVEPVPHDETYCDPASLFHVSN-DY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGK 562 (805) Q Consensus 487 vvepvphdetycdpaslfhvsn-dy--sfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgk 562 (805) -+.+.+ ..-.+.+..|+-. +| .+..|-...++.+++-+.+|+ +|+. +...+.++|+++. ++|..|. T Consensus 611 ~~~~~~---~~~~~~~~~hi~~~~y~a~yY~Y~~a~v~a~~i~~~f~~----~~~~---~~~~~~~~g~~~~~~~L~~G~ 680 (714) T 4KA7_A 611 VIPPLP---EDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFED----AGLD---DIKAVKETGQRFRNTILALGG 680 (714) T ss_dssp SSCCCT---TCCGGGGCHHHHSSTTTTTTTHHHHHHHHHHHHHHHHHH----HCTT---CHHHHHHHHHHHHTTTTTCTT T ss_pred CCCCCC---CCcccccchhhhccCcchHHHHHHHHHHHHHHHHHHHHH----cCCC---chHHHHHHHHHHHHHHhhcCC Confidence 232211 1124456666643 44 444554455555555554444 2321 2234678999999 9999999 Q sp|Q9BYF1|ACE2 563 SEPWTLALENVVGAKNMNVRPLLNYFE 589 (805) Q Consensus 563 sepwtlalenvvgaknmnvrpllnyfe 589 (805) +.++.-.++...|.. .+..+++.++. T Consensus 681 s~~~~e~~~~~~g~~-~~~~~~l~~~~ 706 (714) T 4KA7_A 681 GKAPLKVFVEFRGRE-PSPEPLLRHNG 706 (714) T ss_dssp SSCHHHHHHHHHSSC-CCSHHHHHHTT T ss_pred CCCHHHHHHHHhCCC-CChHHHHHHcC Confidence 999999998877764 66777777653 No 34 >2KNC_B Integrin alpha-IIb, Integrin beta-3; integrin, transmembrane signaling, protein structure; NMR {Homo sapiens} Probab=92.66 E-value=0.036 Score=45.32 Aligned_cols=31 Identities=13% Similarity=0.358 Sum_probs=11.0 Template_Neff=7.700 Q sp|Q9BYF1|ACE2 733 PPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 733 ppnqppvsiwlivfgvvmgvivvgivilift 763 (805) .+...+.+.+.|+.|++.|++++|++++++. T Consensus 2 ~~~~~~~~~~~i~g~vvggiv~l~ll~~~i~ 32 (79) T 2KNC_B 2 AMGSKGPDILVVLLSVMGAILLIGLAALLIW 32 (79) T ss_dssp CSSCS-------------SHHHHHHHHHHHH T ss_pred CCCCCcCchHHHHHHHHHHHHHHHHHHHHHH Confidence 3455677788888888888887777654433 No 35 >2L8S_A Integrin alpha-1; Integrin Alpha1, Transmembrane Region, Detergent; NMR {Homo sapiens} Probab=87.55 E-value=0.29 Score=40.19 Aligned_cols=43 Identities=26% Similarity=0.506 Sum_probs=30.9 Template_Neff=5.400 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKKKNKARSGE 778 (805) Q Consensus 736 qppvsiwlivfgvvmgvivvgivilif--tgirdrkkknkarsge 778 (805) .+++.+|.|+.+++.|++++++++++. .|.-.||++.+....| T Consensus 4 ~~~~p~wiii~svl~GlllL~iii~iL~K~GFFkRk~~~~~~~~~ 48 (54) T 2L8S_A 4 PGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEKLE 48 (54) T ss_dssp CCCCCTHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCSCCCCC-- T ss_pred CCCccHHHHHHHHHHHHHHHHHHHHHHHHcCCCCCCcchHHHHhc Confidence 467889999999999998877765554 5777777766655444 No 36 >2N2A_B Receptor tyrosine-protein kinase erbB-2; HER2, ErbB2, Tyrosine kinase, Activation; NMR {Homo sapiens} Probab=86.49 E-value=0.38 Score=38.36 Aligned_cols=30 Identities=27% Similarity=0.208 Sum_probs=13.8 Template_Neff=7.000 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 742 wlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ..|+.||+.|++++.++++++.-++.|+++ T Consensus 9 ~~I~~~Vvg~l~~~~~i~~~~~~~~Rrr~~ 38 (58) T 2N2A_B 9 TSIISAVVGILLVVVLGVVFGILIKRRQQK 38 (58) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHTTC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 345556655555444444333333434333 No 37 >2KNC_A Integrin alpha-IIb, Integrin beta-3; integrin, transmembrane signaling, protein structure; NMR {Homo sapiens} Probab=85.75 E-value=0.45 Score=38.68 Aligned_cols=40 Identities=23% Similarity=0.570 Sum_probs=29.1 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 735 NQPPVSIWLIVFGVVMGVIVVGIVILI--FTGIRDRKKKNKA 774 (805) Q Consensus 735 nqppvsiwlivfgvvmgvivvgivili--ftgirdrkkknka 774 (805) ..+++++|.|+.+++.|++++++++++ -.|...||++... T Consensus 6 ~~~~~~~wiiv~svl~GlllL~li~~iL~K~GFFkRk~~~~~ 47 (54) T 2KNC_A 6 EERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLE 47 (54) T ss_dssp TTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTCCSCC T ss_pred ccccccHHHHHHHHHHHHHHHHHHHHHHHHcCccccCCCccc Confidence 345788999999999999887766544 4577777665543 No 38 >2M3E_A Integrin alpha-L; integrin alpah L TM domain; NMR {Homo sapiens} Probab=85.42 E-value=0.48 Score=38.20 Aligned_cols=39 Identities=18% Similarity=0.400 Sum_probs=29.1 Template_Neff=5.700 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKKKNKA 774 (805) Q Consensus 736 qppvsiwlivfgvvmgvivvgivilif--tgirdrkkknka 774 (805) ..++.+|.|+.+++.|++++.+++++. .|...||++.+. T Consensus 7 ~~~~~~wiii~svi~GlllL~ii~~iL~K~GFFkRk~~~~~ 47 (50) T 2M3E_A 7 YEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKM 47 (50) T ss_dssp TTCCCHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGSCCCCC T ss_pred chhhcHHHHHHHHHHHHHHHHHHHHHHHHcCcchhhhhHHH Confidence 457889999999999998877765554 566677666543 No 39 >6J8H_C Sodium channel subunit beta-2, Sodium; voltage-gated sodium channel, MEMBRANE PROTEIN; HET: 9SL, NAG;{Homo sapiens} Probab=84.27 E-value=0.6 Score=37.23 Aligned_cols=8 Identities=13% Similarity=0.576 Sum_probs=3.9 Template_Neff=12.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -++|.++. T Consensus 64 ~v~W~~~~ 71 (215) T 6J8H_C 64 SLNWTYQE 71 (215) T ss_pred EEEEEEec Confidence 34555543 No 40 >2N9Y_B Integrin alpha-IIb, Integrin beta-3; transmembrane complex, integrin receptor, cell; NMR {Homo sapiens} Probab=83.96 E-value=0.63 Score=34.96 Aligned_cols=30 Identities=13% Similarity=0.345 Sum_probs=21.3 Template_Neff=7.200 Q sp|Q9BYF1|ACE2 737 PPVSIWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 737 ppvsiwlivfgvvmgvivvgiviliftgir 766 (805) ++.+++.|+.|++-|++++|+++++..-.+ T Consensus 5 ~~~~~~~I~ggvvggi~ligli~lli~~~~ 34 (43) T 2N9Y_B 5 KCPDILVVLLSVMGAILLIGLAPLLIWKLL 34 (43) T ss_dssp SSCCHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CCCcHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345667788899999888887766554443 No 41 >6JXR_n T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=83.38 E-value=0.7 Score=37.95 Aligned_cols=7 Identities=14% Similarity=0.700 Sum_probs=3.7 Template_Neff=12.900 Q sp|Q9BYF1|ACE2 591 LFTWLKD 597 (805) Q Consensus 591 lftwlkd 597 (805) -+.|.++ T Consensus 154 ~~~W~~~ 160 (291) T 6JXR_n 154 ELSWWVN 160 (291) T ss_pred eEEEEEC Confidence 4556553 No 42 >2K9J_A Integrin alpha-IIb light chain, Integrin; integrin, transmembrane complex, Cell adhesion; NMR {Homo sapiens} Probab=83.01 E-value=0.74 Score=35.92 Aligned_cols=39 Identities=26% Similarity=0.696 Sum_probs=28.8 Template_Neff=5.800 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKK 770 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilif--tgirdrkk 770 (805) ||+..+++.+|.|+.+++.|++++.+++++. .|.-.||+ T Consensus 1 ~~~~~~~~~~wiii~svl~GlllL~li~~iL~K~GFFkRk~ 41 (42) T 2K9J_A 1 GALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNR 41 (42) T ss_dssp CCSSCSCCHHHHHHHHHHHHHHHHHHHHHHHHTTTSSCCCC T ss_pred CchhhccccHHHHHHHHHHHHHHHHHHHHHHHHhCccccCC Confidence 5667788999999999999998887765554 34444443 No 43 >2N5S_A Epidermal growth factor receptor (E.C.2.7.10.1); transmembrane, TRANSFERASE; NMR {Homo sapiens} Probab=82.67 E-value=0.79 Score=34.05 Aligned_cols=10 Identities=30% Similarity=0.504 Sum_probs=4.2 Template_Neff=8.700 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVI 753 (805) Q Consensus 744 ivfgvvmgvi 753 (805) |+.|++.|++ T Consensus 8 i~~gvv~~~~ 17 (54) T 2N5S_A 8 IATGMVGALL 17 (54) T ss_dssp TTHHHHHHHH T ss_pred HHHHHHHHHH Confidence 3444444433 No 44 >4UM8_D INTEGRIN ALPHA-V, INTEGRIN BETA-6; IMMUNE SYSTEM, CELL SURFACE RECEPTOR; HET: CAC, SO4, NAG, CA, MAN, BMA; 2.852A {HOMO SAPIENS} Probab=80.82 E-value=1 Score=48.98 Aligned_cols=25 Identities=32% Similarity=0.786 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.|++++|+++|+. T Consensus 705 ~~~~~~i~~gvv~~ivli~l~~l~i 729 (788) T 4UM8_D 705 PPNIPMIMLGVSLAILLIGVVLLCI 729 (788) T ss_dssp ------------------------- T ss_pred CCCHHHHHHHHHHHHHHHHHHHHHH Confidence 5667788889888888888776654 No 45 >4UM8_B INTEGRIN ALPHA-V, INTEGRIN BETA-6; IMMUNE SYSTEM, CELL SURFACE RECEPTOR; HET: MAN, NAG, CA, SO4, CAC, BMA; 2.852A {HOMO SAPIENS} Probab=78.69 E-value=1.4 Score=48.08 Aligned_cols=25 Identities=32% Similarity=0.786 Sum_probs=19.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.|++++|+++|+. T Consensus 705 ~~~~~~i~~gvv~~ivll~l~~lli 729 (788) T 4UM8_B 705 PPNIPMIMLGVSLAILLIGVVLLCI 729 (788) T ss_pred CchHHHHHHHHHHHHHHHHHHHHHH Confidence 5677888888888888887766543 No 46 >1AFO_A GLYCOPHORIN A; INTEGRAL MEMBRANE PROTEIN, HUMAN GLYCOPHORIN; NMR {Homo sapiens} SCOP: j.35.1.1 Probab=75.93 E-value=1.9 Score=35.46 Aligned_cols=37 Identities=46% Similarity=0.680 Sum_probs=25.9 Template_Neff=2.500 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) .++-+.|+ |.+|+|||+.|+ +|++++|-..||.-+|| T Consensus 4 ~h~fs~p~-i~lII~~VmaGI--IG~Il~i~y~I~rl~kk 40 (40) T 1AFO_A 4 AHHFSEPE-ITLIIFGVMAGV--IGTILLISYGIRRLIKK 40 (40) T ss_dssp SCCSSCCH-HHHHHHHHHHHH--HHHHHHHHHHHHHHSCC T ss_pred ccCCChHH-HHHHHHHHHHHH--HHHHHHHHHHHHHHhcC Confidence 34445555 789999999987 46777777777765554 No 47 >6A69_B Plasma membrane calcium-transporting ATPase 1; Membrane protein, STRUCTURAL PROTEIN; HET: NAG; 4.11A {Homo sapiens} Probab=75.89 E-value=1.9 Score=35.66 Aligned_cols=15 Identities=13% Similarity=0.375 Sum_probs=6.6 Template_Neff=12.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVG 756 (805) Q Consensus 742 wlivfgvvmgvivvg 756 (805) +.+++|++++++++. T Consensus 224 ~~~~~~~~~~~~~~~ 238 (282) T 6A69_B 224 LWPFLGILAEIIILV 238 (282) T ss_pred HHHHHHHHHHHHHHH Confidence 334445444444433 No 48 >6AGF_B Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a; sodium channel, MEMBRANE PROTEIN; HET: 6OU, 9Z9, NAG, BMA; 3.2A {Homo sapiens} Probab=75.28 E-value=2 Score=35.68 Aligned_cols=22 Identities=18% Similarity=0.176 Sum_probs=0.4 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 773 KARSGENPYASIDISKGENNPGF 795 (805) Q Consensus 773 karsgenpyasidiskgennpgf 795 (805) +.+..+.+|+.+... ..+|+.. T Consensus 192 ~~~~~~~~~~~~~~~-~~~~~~~ 213 (218) T 6AGF_B 192 AAQENASEYLAITSE-SKENCTG 213 (218) T ss_dssp C---------------------- T ss_pred HHHhhHhhhcccChh-hhhcccc Confidence 344446677766533 3344433 No 49 >6J8J_B Sodium channel subunit beta-2, Sodium; voltage-gated sodium channel, MEMBRANE PROTEIN; HET: 9SR, NAG;{Homo sapiens} Probab=75.28 E-value=2 Score=35.68 Aligned_cols=22 Identities=18% Similarity=0.176 Sum_probs=11.0 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 773 KARSGENPYASIDISKGENNPGF 795 (805) Q Consensus 773 karsgenpyasidiskgennpgf 795 (805) +.+..+.+|+.+... ..+|+.. T Consensus 192 ~~~~~~~~~~~~~~~-~~~~~~~ 213 (218) T 6J8J_B 192 AAQENASEYLAITSE-SKENCTG 213 (218) T ss_pred HHHhhHhhhcccChh-hhhcccc Confidence 344446677766533 3344433 No 50 >6C14_A Protocadherin-15, LHFPL tetraspan subfamily member; PCDH15, LHFPL5, protocadherin, tip link;{Mus musculus} Probab=74.52 E-value=2.2 Score=40.59 Aligned_cols=23 Identities=4% Similarity=0.128 Sum_probs=12.6 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVIL 760 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivil 760 (805) +..+.+|+++++++++++.++++ T Consensus 238 ~~~~~li~laill~l~~lili~~ 260 (337) T 6C14_A 238 YTEGALLALAFIIILCCIPAILV 260 (337) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHH Confidence 33556677776666654433333 No 51 >6UJB_B Integrin alpha-V, Integrin beta-8, C6D4; glycoprotein, adhesion, signaling, SIGNALING PROTEIN-IMMUNE; HET: MAN, NAG, BMA; 3.51A {Homo sapiens} Probab=73.28 E-value=2.5 Score=45.78 Aligned_cols=25 Identities=16% Similarity=0.359 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.+++++++++|++ T Consensus 637 ~~~~~~i~~~v~~~illi~l~~l~i 661 (727) T 6UJB_B 637 SPSYLRIFFIIFIVTFLIGLLKVLI 661 (727) T ss_dssp ------------------------- T ss_pred CccHHHHHHHHHHHHHHHHHHHHHH Confidence 4567788888888887777665543 No 52 >6UJA_B Integrin alpha-V, Integrin beta-8, Transforming; glycoprotein, adhesion, signaling, SIGNALING PROTEIN; HET: MAN, BMA, NAG; 3.3A {Homo sapiens} Probab=73.28 E-value=2.5 Score=45.78 Aligned_cols=25 Identities=16% Similarity=0.359 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.+++++++++|++ T Consensus 637 ~~~~~~i~~~v~~~illi~l~~l~i 661 (727) T 6UJA_B 637 SPSYLRIFFIIFIVTFLIGLLKVLI 661 (727) T ss_dssp ------------------------- T ss_pred CccHHHHHHHHHHHHHHHHHHHHHH Confidence 4567788888888887777665543 No 53 >2M20_A Epidermal growth factor receptor (E.C.2.7.10.1); Transmembrane, Cell Signaling, Juxtamembrane, SIGNALING; NMR {Homo sapiens} Probab=72.68 E-value=2.6 Score=32.92 Aligned_cols=10 Identities=30% Similarity=0.511 Sum_probs=4.3 Template_Neff=7.900 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVI 753 (805) Q Consensus 744 ivfgvvmgvi 753 (805) |+.|||.|++ T Consensus 5 i~~~vvg~~~ 14 (60) T 2M20_A 5 IATGLVGALL 14 (60) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 3444444433 No 54 >5OR7_C Capsid protein, CMRF35-like molecule 1; CR10, sCD300lf, complex, VIRAL PROTEIN; 2.046A {Murine norovirus GV/CR10/2005/USA} Probab=72.61 E-value=2.7 Score=38.46 Aligned_cols=6 Identities=17% Similarity=0.506 Sum_probs=2.6 Template_Neff=11.000 Q sp|Q9BYF1|ACE2 592 FTWLKD 597 (805) Q Consensus 592 ftwlkd 597 (805) +.|.++ T Consensus 52 v~W~~~ 57 (330) T 5OR7_C 52 KYWCQG 57 (330) T ss_pred EEEEEC Confidence 344443 No 55 >2MFR_A Insulin receptor (E.C.2.7.10.1); insulin recepotr, membrane protein, detergent; NMR {Homo sapiens} Probab=69.03 E-value=3.6 Score=33.93 Aligned_cols=38 Identities=21% Similarity=0.174 Sum_probs=19.5 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 740 SIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN 779 (805) Q Consensus 740 siwlivfgvvmgvivvgiviliftgirdrkkknkarsgen 779 (805) +++++++|.+..++++.+++. ...-.+|||+..|+||. T Consensus 15 ~~~~iiI~pvi~iilii~~~~--~~~~~~kKr~~~~~~~~ 52 (57) T 2MFR_A 15 NIAKIIIGPLIFVFLFSVVIG--SIYLFLRKRQPDGPLEH 52 (57) T ss_dssp HHHHHHHHHHHHHHHHHHHHH--HHHHHHTSSCCCCSSSC T ss_pred hHHHHHHHHHHHHHHHHHHHH--HHHHHHhccCCCCCCCC Confidence 344555555544443332222 22344566777788874 No 56 >4U0Q_B Plasmodium falciparum Reticulocyte-binding protein homologue; Malaria Erythrocyte invasion, signaling protein; 3.1A {Plasmodium falciparum} Probab=67.25 E-value=4.2 Score=33.78 Aligned_cols=13 Identities=31% Similarity=0.493 Sum_probs=0.0 Template_Neff=12.500 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVIVVG 756 (805) Q Consensus 744 ivfgvvmgvivvg 756 (805) +++|++++++++. T Consensus 211 ~~~~~~~~~~~~~ 223 (269) T 4U0Q_B 211 PFLGIVAEVLVLV 223 (269) T ss_dssp ------------- T ss_pred HHHHHHHHHHHHH Confidence 3445544444443 No 57 >5A2F_A CD166 ANTIGEN; CELL ADHESION, ALCAM, ACTIVATED LEUKOCYTE; HET: EDO, NAG; 1.86A {HOMO SAPIENS} Probab=63.73 E-value=5.5 Score=38.68 Aligned_cols=11 Identities=18% Similarity=0.585 Sum_probs=0.0 Template_Neff=11.600 Q sp|Q9BYF1|ACE2 589 EPLFTWLKDQN 599 (805) Q Consensus 589 eplftwlkdqn 599 (805) .|.++|.++.. T Consensus 442 ~~~i~W~~~~~ 452 (583) T 5A2F_A 442 KPAIQWTITGS 452 (583) T ss_dssp ----------- T ss_pred CCEEEEEECCc Confidence 35566766543 No 58 >2KLU_A T-cell surface glycoprotein CD4; Protein, Cell membrane, Disulfide bond; NMR {Homo sapiens} Probab=59.80 E-value=7.3 Score=30.35 Aligned_cols=9 Identities=56% Similarity=0.881 Sum_probs=3.7 Template_Neff=8.800 Q sp|Q9BYF1|ACE2 744 IVFGVVMGV 752 (805) Q Consensus 744 ivfgvvmgv 752 (805) +++|++.++ T Consensus 12 ~~vg~~~~~ 20 (70) T 2KLU_A 12 IVLGGVAGL 20 (70) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 344444443 No 59 >6ENY_C Beta-2-microglobulin, Tapasin, Protein disulfide-isomerase A3; adaptive immunity, antigen processing, chaperone; HET: BGC, MAN, NAG; 5.8A {Homo sapiens} Probab=58.02 E-value=8.2 Score=37.78 Aligned_cols=9 Identities=11% Similarity=-0.142 Sum_probs=4.5 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 539 LHKCDISNS 547 (805) Q Consensus 539 lhkcdisns 547 (805) .+.|.+.+. T Consensus 248 ~Y~C~~~~~ 256 (428) T 6ENY_C 248 TYLATIHLP 256 (428) T ss_pred EEEEEEEcC Confidence 455555443 No 60 >1S7Q_A H-2 class I histocompatibility antigen; LCMV, MHC class I, immune; 1.99A {Mus musculus} SCOP: d.19.1.1, b.1.1.2 Probab=57.91 E-value=8.2 Score=37.47 Aligned_cols=11 Identities=27% Similarity=0.314 Sum_probs=0.0 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGV 752 (805) Q Consensus 742 wlivfgvvmgv 752 (805) +.++.+++.++ T Consensus 285 ~~~~~~~~~~~ 295 (348) T 1S7Q_A 285 ATVAVLVVLGA 295 (348) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 43333444343 No 61 >1S7S_A H-2 class I histocompatibility antigen; LCMV, MHC class I, immune; 1.99A {Mus musculus} SCOP: d.19.1.1, b.1.1.2 Probab=57.91 E-value=8.2 Score=37.47 Aligned_cols=11 Identities=27% Similarity=0.314 Sum_probs=0.0 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGV 752 (805) Q Consensus 742 wlivfgvvmgv 752 (805) +.++.+++.++ T Consensus 285 ~~~~~~~~~~~ 295 (348) T 1S7S_A 285 ATVAVLVVLGA 295 (348) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 43333444343 No 62 >2WY3_A MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE; IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX, IMMUNE; HET: PEU, NAG, ACT; 1.8A {HUMAN HERPESVIRUS 5 STRAIN AD169} Probab=57.28 E-value=8.6 Score=35.83 Aligned_cols=9 Identities=33% Similarity=0.674 Sum_probs=4.8 Template_Neff=10.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQN 599 (805) Q Consensus 591 lftwlkdqn 599 (805) .++|.++.. T Consensus 214 ~~~W~~~~~ 222 (319) T 2WY3_A 214 TLTWRQDGV 222 (319) T ss_pred EEEEEECCE Confidence 356666543 No 63 >6JXR_f T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=55.13 E-value=9.8 Score=32.92 Aligned_cols=14 Identities=14% Similarity=-0.228 Sum_probs=6.0 Template_Neff=10.700 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIV 754 (805) Q Consensus 741 iwlivfgvvmgviv 754 (805) +..|++|++.++++ T Consensus 130 i~~iv~g~~~~~l~ 143 (207) T 6JXR_f 130 VATIVIVDICITGG 143 (207) T ss_pred HHHHHHHHHHHHHH Confidence 33344554444333 No 64 >3LB6_C Interleukin-13, Interleukin-13 receptor subunit alpha-2; cytokine, receptor, decoy, decoy receptor; HET: NAG, MLY; 3.05A {Homo sapiens} Probab=54.78 E-value=10 Score=33.26 Aligned_cols=18 Identities=11% Similarity=0.165 Sum_probs=10.5 Template_Neff=12.600 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|.-.+.|-|.+ T Consensus 293 ~~~~~L~~~~~Y~~~V~a 310 (380) T 3LB6_C 293 YTLKTTNETRQLCFVVRS 310 (380) T ss_pred EEEecCCCCceEEEEEEE Confidence 445566666666665554 No 65 >3LB6_D Interleukin-13, Interleukin-13 receptor subunit alpha-2; cytokine, receptor, decoy, decoy receptor; HET: NAG; 3.05A {Homo sapiens} Probab=54.78 E-value=10 Score=33.26 Aligned_cols=18 Identities=11% Similarity=0.165 Sum_probs=7.8 Template_Neff=12.600 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|.-.+.|-|.+ T Consensus 293 ~~~~~L~~~~~Y~~~V~a 310 (380) T 3LB6_D 293 YTLKTTNETRQLCFVVRS 310 (380) T ss_dssp EEECC----CCEEEEEEE T ss_pred EEEecCCCCceEEEEEEE Confidence 445566666666665554 No 66 >6FGB_A IgG receptor FcRn large subunit; FcRn, rozanolixizumab, ECD, Fab, immune; 2.9A {Homo sapiens} Probab=49.49 E-value=14 Score=35.50 Aligned_cols=10 Identities=10% Similarity=-0.157 Sum_probs=4.5 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 776 SGENPYASID 785 (805) Q Consensus 776 sgenpyasid 785 (805) +..+++.+++ T Consensus 311 ~~~~~~~~~~ 320 (342) T 6FGB_A 311 SLRGDDTGVL 320 (342) T ss_pred cCCCCCCCCc Confidence 3344555443 No 67 >4NKQ_B Cytokine receptor common subunit beta; GM-CSF, receptor complex, dodecamer, Disease; HET: NAG; 3.301A {Homo sapiens} Probab=46.89 E-value=16 Score=32.21 Aligned_cols=18 Identities=17% Similarity=0.263 Sum_probs=10.6 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|...+.|-|.+ T Consensus 186 ~~l~~L~p~t~Y~~~V~a 203 (305) T 4NKQ_B 186 YNFPSSEPRAKHSVKIRA 203 (305) T ss_pred EEccCCCCCCcEEEEEEE Confidence 345566666666665554 No 68 >6JXR_g T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=43.82 E-value=20 Score=29.72 Aligned_cols=10 Identities=10% Similarity=0.408 Sum_probs=4.0 Template_Neff=11.300 Q sp|Q9BYF1|ACE2 743 LIVFGVVMGV 752 (805) Q Consensus 743 livfgvvmgv 752 (805) .|++|++.++ T Consensus 117 ~i~~~~~~~~ 126 (182) T 6JXR_g 117 GFLFAEIVSI 126 (182) T ss_pred HHHHHHHHHH Confidence 3444443333 No 69 >5EH6_A Glycophorin-A; Receptor, lipidic cubic phase, peptides; 1.918A {Homo sapiens} Probab=43.27 E-value=20 Score=28.46 Aligned_cols=24 Identities=58% Similarity=1.035 Sum_probs=18.2 Template_Neff=2.200 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 741 iwlivfgvvmgvivvgiviliftgir 766 (805) |.+|+|||..|| +|.++||-..|| T Consensus 4 I~lII~~vmagv--ig~ILlI~y~I~ 27 (30) T 5EH6_A 4 ITLIIFGVIAGV--IGTILLISYGIR 27 (30) T ss_dssp HHHHHHHHHHHH--HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH--HHHHHHHHHHHH Confidence 778999999987 466666666665 No 70 >5EH4_C Glycophorin-A; Receptor, lipidic cubic phase, peptides; HET: SCH, OLB; 2.81A {Homo sapiens} Probab=43.27 E-value=20 Score=28.46 Aligned_cols=24 Identities=58% Similarity=1.035 Sum_probs=18.2 Template_Neff=2.200 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 741 iwlivfgvvmgvivvgiviliftgir 766 (805) |.+|+|||..|| +|.++||-..|| T Consensus 4 I~lII~~vmagv--ig~ILlI~y~I~ 27 (30) T 5EH4_C 4 ITLIIFGVIAGV--IGTILLISYGIR 27 (30) T ss_dssp HHHHHHHHHHHH--HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH--HHHHHHHHHHHH Confidence 778999999987 466666666665 No 71 >2XQ2_A SODIUM/GLUCOSE COTRANSPORTER; TRANSPORT PROTEIN, INVERTED REPEATS, LEUT-FOLD; HET: PEG; 2.73A {VIBRIO PARAHAEMOLYTICUS} Probab=39.81 E-value=25 Score=38.03 Aligned_cols=33 Identities=45% Similarity=0.708 Sum_probs=25.2 Template_Neff=8.700 Q sp|Q9BYF1|ACE2 739 VSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNK 773 (805) Q Consensus 739 vsiwlivfgvvmgvivvgiviliftgirdrkkknk 773 (805) .-||+|+|||..||| |++.+|-.+||.-.||+. T Consensus 548 ~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 580 (593) T 2XQ2_A 548 AEITLIIFGVMAGVI--GTILLISYGIKKLIKASY 580 (593) T ss_pred HHHHHHHHHHHHHHH--HHHHHHHHHHHHHhhcCC Confidence 346999999998865 677788888887666653 No 72 >2RDD_B Acriflavine resistance protein B, UPF0092; DRUG RESISTANCE, MULTIDRUG EFFLUX, TRANSPORTER; HET: AIC; 3.5A {Escherichia coli} Probab=39.22 E-value=26 Score=26.11 Aligned_cols=20 Identities=25% Similarity=0.323 Sum_probs=11.5 Template_Neff=6.900 Q sp|Q9BYF1|ACE2 756 GIVILIFTGIRDRKKKNKAR 775 (805) Q Consensus 756 giviliftgirdrkkknkar 775 (805) .++++.|.-+|..||+.|++ T Consensus 12 ~~~~~~~~~~rpqkK~~k~~ 31 (37) T 2RDD_B 12 FGLIFYFMILRPQQKRTKEH 31 (37) T ss_dssp HHHHHHHHTHHHHHHHHHHH T ss_pred HHHHHHHHHHCHHHHHHHHH Confidence 34445555667766666554 No 73 >6CPL_A HLA class II histocompatibility antigen; IMMUNE RECEPTOR, IMMUNE SYSTEM; HET: NAG, SO4; 2.45A {Homo sapiens} Probab=39.13 E-value=26 Score=31.32 Aligned_cols=8 Identities=38% Similarity=0.904 Sum_probs=4.3 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -.+|.++. T Consensus 118 ~v~W~~~~ 125 (229) T 6CPL_A 118 NVTWLRNG 125 (229) T ss_pred EEEEEECC Confidence 45666554 No 74 >6EJ2_A Beta-secretase 1 (E.C.3.4.23.46); BACE1, protease, Alzheimer, PEPTIDE BINDING; HET: B7E; 1.46A {Homo sapiens} Probab=38.02 E-value=28 Score=35.18 Aligned_cols=15 Identities=7% Similarity=0.138 Sum_probs=0.0 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVM 750 (805) Q Consensus 736 qppvsiwlivfgvvm 750 (805) ....++..|+.++|- T Consensus 452 ~~~~~~~~ivg~~vg 466 (501) T 6EJ2_A 452 ESTLMTIAYVMAAIC 466 (501) T ss_dssp --------------- T ss_pred CCcchHHHHHHHHHH Confidence 334444444444333 No 75 >6ENY_F Beta-2-microglobulin, Tapasin, Protein disulfide-isomerase A3; adaptive immunity, antigen processing, chaperone; HET: NAG, MAN, BGC; 5.8A {Homo sapiens} Probab=37.88 E-value=28 Score=33.91 Aligned_cols=6 Identities=50% Similarity=1.359 Sum_probs=2.8 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 592 FTWLKD 597 (805) Q Consensus 592 ftwlkd 597 (805) .+|.++ T Consensus 215 v~W~~~ 220 (341) T 6ENY_F 215 LTWQRD 220 (341) T ss_dssp EEEEET T ss_pred EEEEeC Confidence 445444 No 76 >5XTH_0 NADH dehydrogenase [ubiquinone] flavoprotein 1; Homo sapiens, Oxidoreductase, Respiratory, Supercomplex; HET: PEE, CDL, HEA, HEC, FES, PLX, 8Q1, HEM, NDP, SF4, FMN; 3.9A {Homo sapiens} Probab=37.10 E-value=29 Score=33.41 Aligned_cols=32 Identities=22% Similarity=0.281 Sum_probs=22.9 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilift 763 (805) ||+-++|..-|-.|+|.++++|.+++++.++. T Consensus 65 ~~e~~~p~g~wK~v~~~v~~~~~~s~~lf~~~ 96 (144) T 5XTH_0 65 FAEMNRSTNEWKTVVGAAMFFIGFTALLLIWE 96 (144) T ss_pred cccccCCCchHHHHHHHHHHHHHHHHHHHHHH Confidence 45667888889888888887776666555543 No 77 >5B1A_D Cytochrome c oxidase subunit 1; Oxidoreductase, Proton pump, Heme, Respiratory; HET: FME, CDL, TGL, HEA, PGV, CHD, PSC, PEK, DMU, TPO, SAC; 1.5A {Bos taurus} Probab=33.75 E-value=36 Score=33.09 Aligned_cols=32 Identities=22% Similarity=0.281 Sum_probs=22.9 Template_Neff=5.700 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilift 763 (805) ||+-++|...|-.|||.+++++.+++++.++. T Consensus 68 gp~~~~p~~~~k~v~~~~~~~~~~s~~l~~~~ 99 (147) T 5B1A_D 68 FAEMNRSTNEWKTVVGAAMFFIGFTALLLIWE 99 (147) T ss_dssp HHHHTCCCSHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cccccCCCchHHHHHHHHHHHHHHHHHHHHHH Confidence 55667888889888888877776666555543 No 78 >6PY2_A HLA class II histocompatibility antigen; HLA, MHC, TCR, Gluten, IMMUNE; HET: NAG, GOL; 2.82543430029A {Homo sapiens} Probab=33.31 E-value=37 Score=31.36 Aligned_cols=9 Identities=33% Similarity=0.785 Sum_probs=5.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 591 LFTWLKDQN 599 (805) Q Consensus 591 lftwlkdqn 599 (805) -++|.++.. T Consensus 143 ~v~W~~~g~ 151 (254) T 6PY2_A 143 NITWLSNGH 151 (254) T ss_dssp EEEEEETTE T ss_pred EEEEEECCE Confidence 477777643 No 79 >6GJE_A Protein amnionless, Cubilin; receptor, vitamin B12, cubilin, amnionless; 2.3A {Homo sapiens} Probab=33.17 E-value=37 Score=37.81 Aligned_cols=18 Identities=28% Similarity=0.311 Sum_probs=0.0 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 783 SIDISKGENNPGFQNTDD 800 (805) Q Consensus 783 sidiskgennpgfqntdd 800 (805) .-...+|-.||-|....+ T Consensus 399 ~~~~~~gf~NP~fd~~~~ 416 (453) T 6GJE_A 399 PAGAPLGFRNPVFDVTAS 416 (453) T ss_dssp ------------------ T ss_pred CCCCCCCcCCccccCCCC Confidence 556778889998877644 No 80 >6C13_A Protocadherin-15; PCDH15, LHFPL5, protocadherin, tip link; HET: MAN, BMA, NAG;{Mus musculus} Probab=32.87 E-value=38 Score=34.96 Aligned_cols=13 Identities=31% Similarity=0.317 Sum_probs=6.8 Template_Neff=10.700 Q sp|Q9BYF1|ACE2 693 DIIPRTEVEKAIR 705 (805) Q Consensus 693 diiprtevekair 705 (805) .++.+.++.+.+. T Consensus 508 ~i~~~~~~~~~l~ 520 (660) T 6C13_A 508 RAIDRNELFKFLD 520 (660) T ss_dssp EECCHHHHHHHHH T ss_pred eEecHHHHHHHHh Confidence 3555555555544 No 81 >5DJQ_P Cbb3-type cytochrome c oxidase subunit; oxidoreductase, cbb3-cytochrome c oxidase, Pseudomonas_stutzeri; HET: PO4, HEC, FC6, HEM; 3.2A {Pseudomonas stutzeri} Probab=32.78 E-value=38 Score=27.68 Aligned_cols=24 Identities=42% Similarity=0.845 Sum_probs=13.0 Template_Neff=3.100 Q sp|Q9BYF1|ACE2 748 VVMGVIVVGIVILIFTGI-----RDRKKK 771 (805) Q Consensus 748 vvmgvivvgiviliftgi-----rdrkkk 771 (805) |+.|+++||..++.|.|. ||.+|| T Consensus 7 ViaGi~tVglm~~Ff~G~g~FIwkD~~k~ 35 (36) T 5DJQ_P 7 VLAGVVTVGLMVAFLAGFGYFIWRDAHKK 35 (36) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHC------ T ss_pred HHHHHHHHHHHHHHHHHHHHHHhHhhhhc Confidence 566777788877777764 555554 No 82 >1CD1_A CD1; CD1, IMMUNOLOGY, MHC, TCR, GLYCOPROTEIN; 2.67A {Mus musculus} SCOP: b.1.1.2, d.19.1.1 Probab=32.51 E-value=39 Score=31.77 Aligned_cols=7 Identities=14% Similarity=0.961 Sum_probs=3.3 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 592 FTWLKDQ 598 (805) Q Consensus 592 ftwlkdq 598 (805) .+|+++. T Consensus 217 v~W~~~g 223 (315) T 1CD1_A 217 VMWMRGD 223 (315) T ss_dssp EEEEETT T ss_pred EEEEECC Confidence 4555443 No 83 >6AT5_A HLA class I histocompatibility antigen; Human Leukocyte Antigen, Major histocompatibility; 1.5A {Homo sapiens} Probab=29.91 E-value=46 Score=33.01 Aligned_cols=8 Identities=38% Similarity=0.924 Sum_probs=4.5 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -.+|.++. T Consensus 238 ~v~W~~~g 245 (362) T 6AT5_A 238 TLTWQRDG 245 (362) T ss_dssp EEEEEETT T ss_pred EEEEEeCC Confidence 35666653 No 84 >4JIX_A Uncharacterized protein MJ0123; Hydrolase, Metallopeptidase Zymogen, Minigluzincin; HET: GOL, SO4; 2.0A {Methanocaldococcus jannaschii} Probab=28.17 E-value=51 Score=27.66 Aligned_cols=41 Identities=20% Similarity=0.211 Sum_probs=24.4 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 371 TAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSI 421 (805) Q Consensus 371 tahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksi 421 (805) +--|||+|+... ..+-+..|...+..++.-...--+.|+.. T Consensus 68 vi~HEl~H~~~~----------~~~H~~~f~~~~~~~~p~~~~~~~~l~~~ 108 (112) T 4JIX_A 68 IILHELIHFKIK----------SINHGIKFENELRNYFSKNECDEIELKII 108 (112) T ss_dssp HHHHHHHHHHHT----------CSSCSHHHHHHHTTTCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHhh----------cccccHHHHHHHHHHcccchhhHHHHHHH Confidence 557999999762 23334567777766665544444444443 No 85 >4JIX_B Projannalysin; Hydrolase, Metallopeptidase Zymogen, Minigluzincin; HET: SO4, GOL; 2.0A {Methanocaldococcus jannaschii} Probab=28.17 E-value=51 Score=27.66 Aligned_cols=41 Identities=20% Similarity=0.211 Sum_probs=24.4 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 371 TAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSI 421 (805) Q Consensus 371 tahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksi 421 (805) +--|||+|+... ..+-+..|...+..++.-...--+.|+.. T Consensus 68 vi~HEl~H~~~~----------~~~H~~~f~~~~~~~~p~~~~~~~~l~~~ 108 (112) T 4JIX_B 68 IILHELIHFKIK----------SINHGIKFENELRNYFSKNECDEIELKII 108 (112) T ss_dssp HHHHHHHHHHHT----------CSCCSHHHHHHHTTTCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHhh----------cccccHHHHHHHHHHcccchhhHHHHHHH Confidence 557999999762 23334567777766665544444444443 No 86 >6IDF_E Nicastrin, Presenilin-1 (E.C.3.4.23.-), Gamma-secretase subunit; complex, MEMBRANE PROTEIN; HET: BMA, NAG, CLR, PC1;{Homo sapiens} Probab=27.63 E-value=53 Score=31.80 Aligned_cols=16 Identities=6% Similarity=0.139 Sum_probs=7.4 Template_Neff=5.100 Q sp|Q9BYF1|ACE2 733 PPNQPPVSIWLIVFGV 748 (805) Q Consensus 733 ppnqppvsiwlivfgv 748 (805) ||..++...|+++.|+ T Consensus 9 ~~~~~~~~~~~v~i~~ 24 (129) T 6IDF_E 9 CPPPAQLHFMYVAAAA 24 (129) T ss_dssp SCCCCSSSHHHHHHTH T ss_pred CCCChhhHHHHHHHHH Confidence 3333344456555444 No 87 >6IVA_D Oxaloacetate decarboxylase beta chain (E.C.7.2.4.2); membrane protein, decarboxylase sodium pump; 4.403A {Salmonella enterica I} Probab=26.48 E-value=58 Score=29.72 Aligned_cols=27 Identities=11% Similarity=0.212 Sum_probs=12.5 Template_Neff=6.300 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIFTG 764 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgiviliftg 764 (805) .+.+-++.+|+|+.++++.++++.+.+ T Consensus 31 ~l~i~iiGm~vVF~vLilL~lvi~l~~ 57 (104) T 6IVA_D 31 GFTLMFLGMGFVLAFLFLLIFAIRGMS 57 (104) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 344445555555555444444333333 No 88 >6IWW_B Oxaloacetate decarboxylase beta chain (E.C.7.2.4.2); membrane protein, sodium pump, decarboxylase; HET: LMT; 3.9A {Salmonella enterica subsp. enterica} Probab=26.48 E-value=58 Score=29.72 Aligned_cols=27 Identities=11% Similarity=0.212 Sum_probs=12.5 Template_Neff=6.300 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIFTG 764 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgiviliftg 764 (805) .+.+-++.+|+|+.++++.++++.+.+ T Consensus 31 ~l~i~iiGm~vVF~vLilL~lvi~l~~ 57 (104) T 6IWW_B 31 GFTLMFLGMGFVLAFLFLLIFAIRGMS 57 (104) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 344445555555555444444333333 No 89 >6BRJ_A Epithelial discoidin domain-containing receptor 1; Kinase, Inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR; HET: VX6; 2.231A {Homo sapiens} Probab=25.27 E-value=63 Score=37.06 Aligned_cols=7 Identities=57% Similarity=1.545 Sum_probs=0.0 Template_Neff=8.500 Q sp|Q9BYF1|ACE2 602 SFVGWST 608 (805) Q Consensus 602 sfvgwst 608 (805) .||||+. T Consensus 254 ~~~~~~~ 260 (876) T 6BRJ_A 254 DYVGWSN 260 (876) T ss_dssp ------- T ss_pred Ceeeeec Confidence 4555543 No 90 >3EHB_B Cytochrome c oxidase subunit 1-beta; proton pumping, water chain, electron; HET: LDA, LMT, HEA; 2.32A {Paracoccus denitrificans} SCOP: f.17.2.1, b.6.1.2 Probab=25.21 E-value=63 Score=33.82 Aligned_cols=47 Identities=15% Similarity=0.255 Sum_probs=20.2 Template_Neff=6.800 Q sp|Q9BYF1|ACE2 725 LGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 725 lgiqptlgppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) +|.|+..+|..+.-...+-.++.+++.+.++..+++++.-+|-|+++ T Consensus 47 ~~~~~~as~~a~~i~~L~~~~l~i~~~I~v~V~~ll~~~i~ryr~~~ 93 (298) T 3EHB_B 47 MNFQPASSPLAHDQQWLDHFVLYIITAVTIFVCLLLLICIVRFNRRA 93 (298) T ss_pred cCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 55666665555544444433333322222222223334444555443 No 91 >6PY2_B HLA class II histocompatibility antigen; HLA, MHC, TCR, Gluten, IMMUNE; HET: NAG, GOL; 2.82543430029A {Homo sapiens} Probab=24.26 E-value=67 Score=30.09 Aligned_cols=11 Identities=36% Similarity=0.760 Sum_probs=0.0 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 745 VFGVVMGVIVV 755 (805) Q Consensus 745 vfgvvmgvivv 755 (805) ++|++++++++ T Consensus 235 ~~~~~~~l~~~ 245 (261) T 6PY2_B 235 IGGFVLGLIFL 245 (261) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 44555555444 No 92 >1Q5B_C EP-cadherin, ectodomain; CADHERIN TRANS INTERACTION ; HET: NDG, NAG, CA; 30.0A {Mus musculus} SCOP: i.20.1.1 Probab=24.14 E-value=68 Score=34.98 Aligned_cols=12 Identities=25% Similarity=0.495 Sum_probs=3.1 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 155 SLDYNERLWAWE 166 (805) Q Consensus 155 sldynerlwawe 166 (805) .+....|-|.|. T Consensus 149 ~~~r~~~~~~~~ 160 (880) T 1Q5B_C 149 GLKRKKRDWVIP 160 (880) T ss_dssp -------CCBCC T ss_pred CCccCCcceeCC Confidence 344455666654 No 93 >2JO1_A Phospholemman; FXYD1, Na,K-ATPase, Micelle, HYDROLASE REGULATOR; NMR {Homo sapiens} Probab=23.89 E-value=69 Score=29.34 Aligned_cols=30 Identities=33% Similarity=0.345 Sum_probs=11.7 Template_Neff=3.400 Q sp|Q9BYF1|ACE2 747 GVVMGVIVVGIVILIFTGIRDRKKKNKARS 776 (805) Q Consensus 747 gvvmgvivvgiviliftgirdrkkknkars 776 (805) |++++++...+.|+|.++-|-|-+.|+.++ T Consensus 20 GLi~A~vLfi~GIliils~kckC~~~q~~~ 49 (72) T 2JO1_A 20 GLVIAGILFILGILIVLSRRCRCKFNQQQR 49 (72) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCTTTS T ss_pred HHHHHHHHHHHHHHHHHhccccccCCcCCC Confidence 444333333333333334444444444333 No 94 >2KV5_A Putative uncharacterized protein RNAI; toxin-antitoxin, bacterial, toxin; NMR {N/A} Probab=23.51 E-value=71 Score=25.42 Aligned_cols=27 Identities=22% Similarity=0.514 Sum_probs=19.0 Template_Neff=4.000 Q sp|Q9BYF1|ACE2 745 VFGVVMGVIVVGIVILIFTGIRD-RKKK 771 (805) Q Consensus 745 vfgvvmgvivvgiviliftgird-rkkk 771 (805) +|-.+++-|+||+++-+|+-.-| |.+| T Consensus 4 if~~IiapiivG~vv~lf~~WL~~r~~k 31 (33) T 2KV5_A 4 LMSLVIAPIFVGLVLEMISRVLDEEDDS 31 (33) T ss_dssp THHHHHHHHHHHHHHHHHHHHTTCCCCC T ss_pred HHHHhHHHHHHHHHHHHHHHHHHhcccc Confidence 45567788889999988886544 4443 No 95 >6BSD_A Epithelial discoidin domain-containing receptor 1; Kinase, Inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR; HET: 1N1; 2.606A {Homo sapiens} Probab=23.31 E-value=72 Score=36.61 Aligned_cols=7 Identities=57% Similarity=1.545 Sum_probs=3.5 Template_Neff=8.500 Q sp|Q9BYF1|ACE2 602 SFVGWST 608 (805) Q Consensus 602 sfvgwst 608 (805) .||||+. T Consensus 254 ~~~~~~~ 260 (876) T 6BSD_A 254 DYVGWSN 260 (876) T ss_pred Ceeeeec Confidence 4555543 No 96 >6KOE_F AA3-600 quinol oxidase subunit I; Menaquinol oxidase, Complex, Proton pumping; HET: HQO, HEA; 3.75A {Bacillus subtilis} Probab=22.61 E-value=76 Score=33.75 Aligned_cols=40 Identities=20% Similarity=0.404 Sum_probs=17.8 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ||..+.-..++++.+++.+.|+++.++++++..+|-|+++ T Consensus 11 gp~a~~~~~l~~~~~~~~l~i~v~V~~l~~~~~~rYR~~~ 50 (296) T 6KOE_F 11 GPVAEQQSDLILLSIGFMLFIVGVVFVLFTIILVKYRDRK 50 (296) T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 4444333333444444444443333444444556655554 No 97 >6KOB_B AA3-600 quinol oxidase subunit I; Menaquinol oxidase, Complex, Proton pumping; HET: MQ7, HEA; 3.6A {Bacillus subtilis} Probab=22.61 E-value=76 Score=33.75 Aligned_cols=40 Identities=20% Similarity=0.404 Sum_probs=15.7 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ||..+.-..++++.+++.+.|+++.++++++..+|-|+++ T Consensus 11 gp~a~~~~~l~~~~~~~~l~i~v~V~~l~~~~~~rYR~~~ 50 (296) T 6KOB_B 11 GPVAEQQSDLILLSIGFMLFIVGVVFVLFTIILVKYRDRK 50 (296) T ss_dssp -----CTTHHHHHHHHHHHHHHHHHHHHTTTSSSSSSCCC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 4444333333444444444443333444444556655554 No 98 >1Q90_G Apocytochrome f, Cytochrome b6, Cytochrome; MEMBRANE PROTEIN COMPLEX, PHOTOSYNTHESIS, ELECTRON; HET: LFA, CLA, BCR, SQD, LMG, HEM, TDS; 3.1A {Chlamydomonas reinhardtii} SCOP: f.23.26.1 Probab=22.36 E-value=78 Score=26.34 Aligned_cols=29 Identities=24% Similarity=0.430 Sum_probs=22.3 Template_Neff=2.400 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVIVVGIVILIFTGIRDRKKKN 772 (805) Q Consensus 744 ivfgvvmgvivvgiviliftgirdrkkkn 772 (805) +.+|+|.|.|.|.++-|.++....-++.+ T Consensus 5 lL~GIVlGli~iTlaGLfv~AY~QyrRg~ 33 (37) T 1Q90_G 5 LLCGIVLGLVPVTIAGLFVTAYLQYLRGD 33 (37) T ss_pred hHHHHHHHhHHHHHHHHHHHHHHHHHhcc Confidence 57899999999998888888765544433 No 99 >2GSM_B Cytochrome c oxidase subunit 1; transmembrane protein complex, OXIDOREDUCTASE; HET: TRD, DMU, HEA; 2.0A {Rhodobacter sphaeroides} SCOP: f.17.2.1, b.6.1.2 Probab=21.90 E-value=80 Score=31.85 Aligned_cols=6 Identities=67% Similarity=1.121 Sum_probs=2.5 Template_Neff=7.600 Q sp|Q9BYF1|ACE2 721 SLEFLG 726 (805) Q Consensus 721 sleflg 726 (805) ||++.| T Consensus 4 ~~~~~~ 9 (262) T 2GSM_B 4 SLEIIG 9 (262) T ss_dssp -CCEEE T ss_pred ccccCC Confidence 455544 No 100 >3HB3_B Cytochrome c oxidase subunit 1-beta; Electron transfer, Proton transfer, Proton; HET: HEA, LDA, LMT; 2.25A {Paracoccus denitrificans} Probab=21.53 E-value=83 Score=32.92 Aligned_cols=47 Identities=15% Similarity=0.280 Sum_probs=18.3 Template_Neff=6.900 Q sp|Q9BYF1|ACE2 725 LGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIV-ILIFTGIRDRKKKN 772 (805) Q Consensus 725 lgiqptlgppnqppvsiwlivfgvvmgvivvgiv-iliftgirdrkkkn 772 (805) ++.|+..+|-.+.-...+-+++++. .+|++++. ++++.-+|-|++++ T Consensus 47 ~~~~~~aS~~a~~i~~L~~~~~~i~-~~Ifv~V~~ll~~~i~ryr~~~~ 94 (298) T 3HB3_B 47 MNFQPASSPLAHDQQWLDHFVLYII-TAVTIFVCLLLLICIVRFNRRAN 94 (298) T ss_dssp CSCSCCCSHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHSBTTTS T ss_pred CCCCCCCCHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHccccCC Confidence 3444444444443333333333332 22222222 23333355555443 No 101 >5X5V_A GD; herpes simplex virus, pseudorabies virus; 1.5A {Suid herpesvirus 1} Probab=20.11 E-value=93 Score=35.59 Aligned_cols=28 Identities=32% Similarity=0.647 Sum_probs=0.0 Template_Neff=3.400 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVGIVILIFTGIRDRK 769 (805) Q Consensus 742 wlivfgvvmgvivvgiviliftgirdrk 769 (805) ..+-.|+.||.|+||+.+.||..+|..| T Consensus 355 v~vgvg~~~~~~~~~~~~~~~~~~~~~~ 382 (402) T 5X5V_A 355 VIVGTGTAMGALLVGVCVYIFFRLRGAK 382 (402) T ss_dssp ---------------------------- T ss_pred eehhHHHHHHHHHHHHHHHHHHHccccc Confidence 3456799999999999999998877654