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| author | guerler |
|---|---|
| date | Thu, 08 Apr 2021 18:22:14 +0000 |
| parents | 64cb5fab9c60 |
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Query NP_000290.2 Match_columns 747 No_of_seqs 3849 out of 40250 Neff 6.23432 Searched_HMMs 998 Date Fri Jul 24 20:45:58 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000290.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000290.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 1XM9_A plakophilin 1 Plakophi 99.7 6.3E-22 7.3E-26 206.9 0.0 453 246-719 3-455 (457) 2 3L6X_A Catenin delta-1, E-cadh 99.4 1.1E-17 1.2E-21 185.5 0.0 438 245-729 48-492 (584) 3 5D5K_C Importin subunit alpha- 98.6 1.1E-11 1.4E-15 126.2 0.0 369 243-713 11-386 (466) 4 3NMZ_A APC variant protein, Rh 98.6 1.3E-11 1.4E-15 129.0 0.0 381 238-715 25-452 (458) 5 4UAF_B Importin alpha 1 import 98.5 1.3E-11 1.6E-15 125.7 0.0 369 243-713 11-386 (466) 6 4U5L_A deltaIBB-importin-alpha 98.5 1.7E-11 2E-15 123.0 0.0 360 246-712 49-425 (426) 7 6SA7_B DARPin-Armadillo fusion 98.5 2.5E-11 2.9E-15 127.0 0.0 136 244-380 172-309 (510) 8 4RV1_D Engineered Protein OR49 98.5 2.7E-11 3.2E-15 120.8 0.0 362 247-715 4-369 (420) 9 6S9O_F designed Armadillo repe 98.5 2.8E-11 3.3E-15 117.9 0.0 167 545-724 170-338 (344) 10 5MFD_C YIIIM''6AII, Capsid dec 98.5 3E-11 3.5E-15 116.2 0.0 318 246-712 5-326 (328) 11 4MZ6_E Deoxyuridine 5'-triphos 98.5 3.5E-11 4E-15 125.0 0.0 368 244-713 56-430 (509) 12 5UMZ_B Importin subunit alpha- 98.5 3.5E-11 4E-15 125.0 0.0 368 244-713 56-430 (509) 13 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 98.4 3.6E-11 4.2E-15 122.1 0.0 367 244-716 19-393 (450) 14 4E4V_A Importin subunit alpha- 98.4 3.6E-11 4.2E-15 124.3 0.0 364 246-716 76-456 (485) 15 4B18_A IMPORTIN SUBUNIT ALPHA- 98.4 4E-11 4.7E-15 121.6 0.0 368 244-717 16-391 (447) 16 4XZR_B Heh1-NLS, Kap60; karyop 98.4 4.3E-11 5E-15 119.8 0.0 363 248-717 4-375 (423) 17 5XZX_A Importin subunit alpha- 98.4 4.3E-11 5.1E-15 119.5 0.0 133 247-380 4-140 (416) 18 1JDH_A BETA-CATENIN, hTcf-4; B 98.4 4.4E-11 5.2E-15 123.9 0.0 378 245-726 101-502 (529) 19 3IFQ_A plakoglobin, E-cadherin 98.4 4.5E-11 5.3E-15 124.5 0.0 381 246-726 104-503 (553) 20 4UAD_A Importin alpha import a 98.4 6E-11 7E-15 121.8 0.0 372 246-723 68-456 (479) 21 5ZHX_D Rap1 GTPase-GDP dissoci 98.4 6.3E-11 7.5E-15 120.9 0.0 407 246-727 19-458 (487) 22 1EE4_A KARYOPHERIN ALPHA; ARM 98.4 8.2E-11 9.6E-15 117.7 0.0 364 247-717 3-375 (423) 23 1EE4_B KARYOPHERIN ALPHA; ARM 98.4 8.2E-11 9.6E-15 117.7 0.0 364 247-717 3-375 (423) 24 4EV8_A Catenin beta-1; mouse c 98.3 9.8E-11 1.2E-14 121.5 0.0 382 246-727 103-504 (538) 25 4RXH_B Importin subunit alpha, 98.3 1.1E-10 1.2E-14 121.7 0.0 365 246-716 72-457 (495) 26 4BQK_A IMPORTIN SUBUNIT ALPHA- 98.3 1.2E-10 1.3E-14 118.5 0.0 366 246-716 46-427 (456) 27 6BW9_A Importin subunit alpha- 98.3 1.3E-10 1.5E-14 118.5 0.0 366 246-717 53-428 (459) 28 1WA5_B GTP-BINDING NUCLEAR PRO 98.3 1.9E-10 2.2E-14 121.4 0.0 134 245-379 173-308 (530) 29 5XGC_A Rap1 GTPase-GDP dissoci 98.3 2E-10 2.3E-14 117.7 0.0 409 246-729 35-476 (503) 30 4BPL_A IMPORTIN SUBUNIT ALPHA- 98.2 2.4E-10 2.9E-14 115.9 0.0 367 246-717 44-426 (454) 31 4B8J_A IMPORTIN SUBUNIT ALPHA- 98.2 2.6E-10 2.9E-14 120.0 0.0 367 246-717 118-500 (528) 32 5T94_B Guanine nucleotide exch 98.2 2.9E-10 3.3E-14 120.5 0.0 364 246-716 131-513 (542) 33 4TNM_A Importin-alpha3 / MOS6; 98.2 3.2E-10 3.7E-14 119.6 0.0 369 246-719 119-504 (531) 34 5TBK_C Importin subunit alpha- 98.2 3.4E-10 3.8E-14 119.3 0.0 366 245-716 71-443 (521) 35 5TBK_D Importin subunit alpha- 98.2 3.4E-10 3.8E-14 119.3 0.0 366 245-716 71-443 (521) 36 2Z6G_A B-catenin; Full-Length, 98.1 6.4E-10 6.8E-14 126.7 0.0 381 245-725 234-634 (780) 37 1JDH_A BETA-CATENIN, hTcf-4; B 98.1 6.1E-10 7.2E-14 115.0 0.0 326 286-717 16-343 (529) 38 2Z6H_A Catenin beta-1; Beta-Ca 98.1 7.3E-10 8.1E-14 121.3 0.0 378 246-673 99-530 (644) 39 6SA8_A ring-like DARPin-Armadi 98.1 7.7E-10 8.7E-14 121.2 0.0 342 244-691 177-522 (671) 40 4RXH_B Importin subunit alpha, 98.1 1.2E-09 1.4E-13 113.4 0.0 157 545-714 196-354 (495) 41 5XJG_A Vacuolar protein 8, Nuc 98.0 1.3E-09 1.5E-13 111.8 0.0 133 246-380 159-293 (506) 42 6KBM_A Vacuolar protein 8, Aut 98.0 1.3E-09 1.5E-13 111.8 0.0 133 246-380 159-293 (506) 43 4TNM_A Importin-alpha3 / MOS6; 98.0 2E-09 2.3E-13 113.3 0.0 158 545-714 243-402 (531) 44 6KBN_A Vacuolar protein 8, Aut 98.0 2.1E-09 2.5E-13 112.9 0.0 133 246-380 153-287 (563) 45 6KBN_C Vacuolar protein 8, Aut 98.0 2.1E-09 2.5E-13 112.9 0.0 133 246-380 153-287 (563) 46 4EV8_A Catenin beta-1; mouse c 98.0 2.1E-09 2.5E-13 111.1 0.0 323 286-716 17-343 (538) 47 4BPL_A IMPORTIN SUBUNIT ALPHA- 98.0 2.2E-09 2.5E-13 108.6 0.0 158 545-714 168-327 (454) 48 4PLS_B Arm00010; PEPTIDE BINDI 98.0 2.5E-09 2.9E-13 100.1 0.0 112 247-359 3-114 (281) 49 5Z8H_A Adenomatous polyposis c 98.0 2.6E-09 3E-13 104.9 0.0 123 258-380 92-219 (339) 50 2Z6H_A Catenin beta-1; Beta-Ca 98.0 2.8E-09 3.1E-13 116.5 0.0 415 246-726 57-499 (644) 51 5AEI_B DESIGNED ARMADILLO REPE 97.9 2.9E-09 3.4E-13 99.9 0.0 114 246-360 5-118 (286) 52 4B8J_A IMPORTIN SUBUNIT ALPHA- 97.9 3.2E-09 3.7E-13 111.3 0.0 160 544-715 199-360 (528) 53 4R10_A Protein humpback-2, Cad 97.9 4.1E-09 4.8E-13 110.8 0.0 417 245-725 73-531 (572) 54 5XJG_A Vacuolar protein 8, Nuc 97.9 4.2E-09 5E-13 107.7 0.0 359 246-716 39-399 (506) 55 6KBM_A Vacuolar protein 8, Aut 97.9 4.2E-09 5E-13 107.7 0.0 359 246-716 39-399 (506) 56 5IZA_A Adenomatous polyposis c 97.9 4.5E-09 5E-13 105.1 0.0 297 236-625 23-335 (354) 57 4R0Z_A Protein humpback-2; arm 97.9 5.4E-09 6.2E-13 112.3 0.0 401 246-718 115-565 (629) 58 4R0Z_A Protein humpback-2; arm 97.9 5.5E-09 6.3E-13 112.2 0.0 418 245-726 73-532 (629) 59 1XM9_A plakophilin 1 Plakophi 97.8 6.1E-09 7E-13 106.4 0.0 350 245-671 44-450 (457) 60 4I2Z_A Protein UNC-45, Heat sh 97.8 7.3E-09 7.1E-13 122.5 0.0 69 247-316 648-716 (961) 61 6SWY_5 Vacuolar import and deg 97.8 7.4E-09 7.2E-13 121.9 0.0 402 240-720 281-784 (921) 62 5IZ8_A Adenomatous polyposis c 97.8 6.6E-09 7.4E-13 103.8 0.0 297 236-625 23-335 (354) 63 3IFQ_A plakoglobin, E-cadherin 97.8 6.4E-09 7.5E-13 107.7 0.0 374 244-725 18-399 (553) 64 4I2W_A Protein UNC-45, Heat sh 97.8 7.9E-09 7.7E-13 122.2 0.0 70 246-316 647-716 (961) 65 4R10_A Protein humpback-2, Cad 97.8 8.7E-09 1E-12 108.2 0.0 398 246-715 115-562 (572) 66 5T94_B Guanine nucleotide exch 97.8 9.3E-09 1.1E-12 108.5 0.0 159 544-715 254-414 (542) 67 6KBN_A Vacuolar protein 8, Aut 97.8 9.2E-09 1.1E-12 107.8 0.0 358 245-714 32-391 (563) 68 6KBN_C Vacuolar protein 8, Aut 97.8 9.2E-09 1.1E-12 107.8 0.0 358 245-714 32-391 (563) 69 2Z6G_A B-catenin; Full-Length, 97.8 1.2E-08 1.3E-12 115.8 0.0 373 244-724 149-529 (780) 70 5EWP_B Uncharacterized protein 97.7 1.3E-08 1.5E-12 96.8 0.0 118 263-381 60-181 (252) 71 5XGC_A Rap1 GTPase-GDP dissoci 97.7 1.3E-08 1.6E-12 103.5 0.0 358 257-715 5-373 (503) 72 6BW9_A Importin subunit alpha- 97.7 1.6E-08 1.9E-12 102.4 0.0 367 244-716 8-381 (459) 73 5D5K_C Importin subunit alpha- 97.7 2E-08 2.4E-12 101.3 0.0 364 246-716 57-437 (466) 74 4UAF_B Importin alpha 1 import 97.6 2.4E-08 2.9E-12 100.7 0.0 364 246-716 57-437 (466) 75 3L6X_A Catenin delta-1, E-cadh 97.6 2.7E-08 2.9E-12 108.4 0.0 364 263-713 26-432 (584) 76 4U5L_A deltaIBB-importin-alpha 97.6 2.9E-08 3.5E-12 98.5 0.0 367 245-713 5-378 (426) 77 4MZ6_E Deoxyuridine 5'-triphos 97.6 3.4E-08 4E-12 101.6 0.0 364 246-716 101-481 (509) 78 5UMZ_B Importin subunit alpha- 97.6 3.4E-08 4E-12 101.6 0.0 364 246-716 101-481 (509) 79 5ZHX_D Rap1 GTPase-GDP dissoci 97.6 3.6E-08 4.2E-12 99.7 0.0 332 282-715 13-357 (487) 80 3NOW_A SD10334p; Armadillo Rep 97.6 3.6E-08 4.2E-12 107.8 0.0 135 244-380 289-431 (810) 81 4EV8_A Catenin beta-1; mouse c 97.5 4.1E-08 4.9E-12 100.9 0.0 137 245-381 267-409 (538) 82 5Z8H_A Adenomatous polyposis c 97.5 4.4E-08 5E-12 95.7 0.0 161 544-716 162-332 (339) 83 3SL9_B Catenin beta-1, B-cell 97.5 4.8E-08 5.5E-12 84.8 0.0 134 245-381 13-150 (167) 84 4E4V_A Importin subunit alpha- 97.5 5E-08 5.7E-12 99.9 0.0 156 546-714 206-363 (485) 85 1WA5_B GTP-BINDING NUCLEAR PRO 97.5 5.1E-08 5.8E-12 102.1 0.0 368 242-716 84-460 (530) 86 1EE4_A KARYOPHERIN ALPHA; ARM 97.5 5.1E-08 6E-12 96.6 0.0 115 245-360 87-201 (423) 87 1EE4_B KARYOPHERIN ALPHA; ARM 97.5 5.1E-08 6E-12 96.6 0.0 115 245-360 87-201 (423) 88 4I2Z_A Protein UNC-45, Heat sh 97.5 6.2E-08 6E-12 114.3 0.0 431 248-725 443-904 (961) 89 5XZX_A Importin subunit alpha- 97.5 6.3E-08 7.4E-12 95.7 0.0 360 246-711 46-415 (416) 90 5MFO_F YIIIM3AIII; Designed ar 97.5 6.9E-08 8.1E-12 85.3 0.0 134 246-380 5-140 (202) 91 3SL9_E Catenin beta-1, B-cell 97.5 7.2E-08 8.3E-12 83.6 0.0 134 245-381 13-150 (167) 92 3NOW_A SD10334p; Armadillo Rep 97.5 7.3E-08 8.5E-12 105.4 0.0 110 247-358 8-120 (810) 93 5MFO_E YIIIM3AIII; Designed ar 97.4 7.9E-08 9.3E-12 84.9 0.0 134 246-380 5-140 (202) 94 4XZR_B Heh1-NLS, Kap60; karyop 97.4 8.1E-08 9.6E-12 95.0 0.0 115 245-360 87-201 (423) 95 3OPB_A SWI5-dependent HO expre 97.4 9.1E-08 9.6E-12 108.6 0.0 168 546-719 544-734 (778) 96 4I2W_A Protein UNC-45, Heat sh 97.4 1E-07 9.8E-12 112.5 0.0 433 247-726 442-905 (961) 97 3TT9_A Plakophilin-2; CELL ADH 97.4 9.1E-08 1E-11 88.5 0.0 221 245-487 8-232 (233) 98 2Z6H_A Catenin beta-1; Beta-Ca 97.4 9.4E-08 1E-11 103.9 0.0 378 241-726 10-395 (644) 99 4U2X_E eVP24, KPNA5C; eVP24, i 97.4 9.4E-08 1.1E-11 83.8 0.0 116 246-362 9-125 (175) 100 4RV1_D Engineered Protein OR49 97.4 9.1E-08 1.1E-11 94.3 0.0 363 246-715 45-411 (420) 101 4BQK_A IMPORTIN SUBUNIT ALPHA- 97.4 9.4E-08 1.1E-11 96.1 0.0 158 545-714 170-329 (456) 102 5TBK_C Importin subunit alpha- 97.4 1E-07 1.2E-11 99.7 0.0 160 544-715 196-357 (521) 103 5TBK_D Importin subunit alpha- 97.4 1E-07 1.2E-11 99.7 0.0 160 544-715 196-357 (521) 104 4U2X_F eVP24, KPNA5C; eVP24, i 97.4 1.2E-07 1.4E-11 83.0 0.0 116 246-362 9-125 (175) 105 4V3Q_A YIII_M4_AII; DE NOVO PR 97.4 1.2E-07 1.4E-11 87.0 0.0 113 247-360 10-122 (247) 106 3NMZ_A APC variant protein, Rh 97.3 1.5E-07 1.7E-11 97.0 0.0 136 245-380 243-389 (458) 107 3L6X_A Catenin delta-1, E-cadh 97.3 1.6E-07 1.7E-11 102.1 0.0 377 246-672 91-522 (584) 108 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 97.3 1.5E-07 1.8E-11 85.8 0.0 113 246-359 5-117 (243) 109 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 97.3 1.5E-07 1.8E-11 85.8 0.0 113 246-359 5-117 (243) 110 5VOZ_P V-type proton ATPase ca 97.3 2.1E-07 2.1E-11 101.0 0.0 134 246-382 124-281 (478) 111 5D80_H V-type proton ATPase ca 97.3 2.1E-07 2.1E-11 101.0 0.0 134 246-382 124-281 (478) 112 1JDH_A BETA-CATENIN, hTcf-4; B 97.3 1.9E-07 2.2E-11 95.6 0.0 138 245-382 266-409 (529) 113 2Z6G_A B-catenin; Full-Length, 97.3 2.2E-07 2.3E-11 105.1 0.0 353 245-671 276-664 (780) 114 1HO8_A VACUOLAR ATP SYNTHASE S 97.3 2.5E-07 2.5E-11 100.5 0.0 135 245-382 125-283 (480) 115 6S9O_F designed Armadillo repe 97.2 2.9E-07 3.4E-11 88.3 0.0 135 246-381 173-309 (344) 116 1XM9_A plakophilin 1 Plakophi 97.2 3.2E-07 3.6E-11 93.1 0.0 114 246-361 332-451 (457) 117 1XQS_B HSPBP1 protein, Heat sh 97.2 3.3E-07 3.7E-11 87.9 0.0 134 246-380 66-203 (280) 118 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 97.2 3.4E-07 4E-11 83.4 0.0 134 246-380 47-182 (243) 119 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 97.2 3.4E-07 4E-11 83.4 0.0 134 246-380 47-182 (243) 120 6SA6_A DARPin-Armadillo fusion 97.2 3.9E-07 4.4E-11 91.0 0.0 134 246-380 200-335 (397) 121 6SA8_A ring-like DARPin-Armadi 97.2 4E-07 4.5E-11 98.8 0.0 135 245-380 220-356 (671) 122 1XQR_A HspBP1 protein; armadil 97.1 4.4E-07 4.9E-11 88.9 0.0 134 246-380 82-219 (296) 123 4UAD_A Importin alpha import a 97.1 4.5E-07 5.3E-11 91.8 0.0 368 245-718 23-398 (479) 124 5MFD_C YIIIM''6AII, Capsid dec 97.1 6.1E-07 7.2E-11 84.8 0.0 114 246-360 89-202 (328) 125 6HB3_B Protein HGH1; solenoid 97.1 7E-07 7.2E-11 92.3 0.0 121 246-369 52-208 (369) 126 3OPB_A SWI5-dependent HO expre 97.1 7.2E-07 7.6E-11 100.9 0.0 156 546-711 605-776 (778) 127 4HXT_A De Novo Protein OR329; 97.0 7.7E-07 9.1E-11 80.9 0.0 113 247-360 4-116 (252) 128 3GQ2_A General vesicular trans 97.0 9.1E-07 9.4E-11 98.4 0.0 136 245-381 60-219 (651) 129 3GRL_A General vesicular trans 97.0 9.1E-07 9.4E-11 98.4 0.0 136 245-381 60-219 (651) 130 4HXT_A De Novo Protein OR329; 97.0 8.1E-07 9.6E-11 80.7 0.0 114 246-360 45-158 (252) 131 4PLS_B Arm00010; PEPTIDE BINDI 97.0 8.3E-07 9.9E-11 82.1 0.0 114 246-360 44-157 (281) 132 5IZA_A Adenomatous polyposis c 97.0 9.5E-07 1.1E-10 87.4 0.0 114 245-358 127-246 (354) 133 5IZ8_A Adenomatous polyposis c 97.0 1E-06 1.1E-10 87.2 0.0 113 246-358 128-246 (354) 134 6SA7_B DARPin-Armadillo fusion 97.0 1.1E-06 1.2E-10 90.6 0.0 135 246-381 342-478 (510) 135 4V3Q_A YIII_M4_AII; DE NOVO PR 97.0 1.1E-06 1.3E-10 80.3 0.0 135 245-380 92-228 (247) 136 5Z8H_A Adenomatous polyposis c 96.9 1.2E-06 1.4E-10 85.0 0.0 134 245-379 122-267 (339) 137 5AEI_B DESIGNED ARMADILLO REPE 96.9 1.4E-06 1.7E-10 80.6 0.0 112 246-358 173-284 (286) 138 5IZA_A Adenomatous polyposis c 96.9 1.5E-06 1.7E-10 85.8 0.0 124 258-381 97-225 (354) 139 5IZ8_A Adenomatous polyposis c 96.9 1.6E-06 1.8E-10 85.8 0.0 124 258-381 97-225 (354) 140 3NMZ_A APC variant protein, Rh 96.9 1.6E-06 1.8E-10 88.9 0.0 135 246-381 287-432 (458) 141 6SA7_B DARPin-Armadillo fusion 96.9 1.6E-06 1.9E-10 89.2 0.0 134 246-380 300-435 (510) 142 5TBK_C Importin subunit alpha- 96.9 1.7E-06 1.9E-10 90.0 0.0 367 246-718 115-491 (521) 143 5TBK_D Importin subunit alpha- 96.9 1.7E-06 1.9E-10 90.0 0.0 367 246-718 115-491 (521) 144 6HB1_A Protein HGH1; solenoid 96.9 1.8E-06 1.9E-10 89.0 0.0 169 547-723 51-256 (369) 145 6HB2_D Protein HGH1; solenoid 96.9 1.8E-06 1.9E-10 89.0 0.0 169 547-723 51-256 (369) 146 5MFD_C YIIIM''6AII, Capsid dec 96.8 1.8E-06 2.1E-10 81.5 0.0 114 246-360 47-160 (328) 147 6SA7_B DARPin-Armadillo fusion 96.8 1.8E-06 2.1E-10 88.8 0.0 115 246-361 384-498 (510) 148 6S9O_F designed Armadillo repe 96.8 2.5E-06 2.9E-10 81.5 0.0 115 245-360 46-160 (344) 149 1XM9_A plakophilin 1 Plakophi 96.8 2.5E-06 2.9E-10 86.1 0.0 167 543-716 82-316 (457) 150 4HXT_A De Novo Protein OR329; 96.8 2.5E-06 2.9E-10 77.3 0.0 114 246-360 129-242 (252) 151 6SA6_A DARPin-Armadillo fusion 96.7 3E-06 3.4E-10 84.2 0.0 132 248-380 160-293 (397) 152 3NMZ_A APC variant protein, Rh 96.7 3.3E-06 3.7E-10 86.5 0.0 135 246-380 190-340 (458) 153 6HB1_A Protein HGH1; solenoid 96.6 5.3E-06 5.5E-10 85.4 0.0 93 287-381 9-108 (369) 154 6HB2_D Protein HGH1; solenoid 96.6 5.3E-06 5.5E-10 85.4 0.0 93 287-381 9-108 (369) 155 2W3C_A GENERAL VESICULAR TRANS 96.6 5.7E-06 5.9E-10 90.0 0.0 135 246-381 71-213 (577) 156 4XZR_B Heh1-NLS, Kap60; karyop 96.6 5.2E-06 6.2E-10 81.4 0.0 114 246-360 172-285 (423) 157 3TT9_A Plakophilin-2; CELL ADH 96.6 6E-06 6.8E-10 75.6 0.0 136 246-382 53-206 (233) 158 6HB3_B Protein HGH1; solenoid 96.6 6.6E-06 6.8E-10 84.6 0.0 93 287-381 9-108 (369) 159 6SA8_A ring-like DARPin-Armadi 96.5 6.4E-06 7.1E-10 88.9 0.0 322 286-714 177-502 (671) 160 1EE4_A KARYOPHERIN ALPHA; ARM 96.5 6.8E-06 8.1E-10 80.5 0.0 114 246-360 214-327 (423) 161 1EE4_B KARYOPHERIN ALPHA; ARM 96.5 6.8E-06 8.1E-10 80.5 0.0 114 246-360 214-327 (423) 162 5KC2_B Phosphatidylinositol 3- 96.5 9.9E-06 1E-09 98.5 0.0 150 546-715 618-768 (1454) 163 4B18_A IMPORTIN SUBUNIT ALPHA- 96.4 8.9E-06 1E-09 80.7 0.0 366 245-716 61-443 (447) 164 1JDH_A BETA-CATENIN, hTcf-4; B 96.4 9E-06 1.1E-09 82.5 0.0 363 245-712 143-529 (529) 165 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 96.4 9.2E-06 1.1E-09 73.3 0.0 135 245-380 88-224 (243) 166 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 96.4 9.2E-06 1.1E-09 73.3 0.0 135 245-380 88-224 (243) 167 4MFU_A Beta-catenin-like prote 96.4 1.1E-05 1.1E-09 87.3 0.0 182 539-725 60-261 (490) 168 5AEI_B DESIGNED ARMADILLO REPE 96.4 1E-05 1.2E-09 74.6 0.0 134 246-380 89-224 (286) 169 4PLS_B Arm00010; PEPTIDE BINDI 96.4 1.1E-05 1.3E-09 74.1 0.0 111 246-357 170-280 (281) 170 4HM9_A Beta-catenin-like prote 96.4 1.4E-05 1.3E-09 88.6 0.0 181 539-725 138-339 (568) 171 3L6X_A Catenin delta-1, E-cadh 96.4 1.3E-05 1.4E-09 86.3 0.0 135 246-381 236-406 (584) 172 4U5L_A deltaIBB-importin-alpha 96.4 1.2E-05 1.4E-09 78.7 0.0 134 246-380 223-359 (426) 173 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 96.3 1.3E-05 1.5E-09 79.6 0.0 366 245-716 64-446 (450) 174 3GQ2_A General vesicular trans 96.3 1.5E-05 1.5E-09 88.2 0.0 169 543-721 204-403 (651) 175 3GRL_A General vesicular trans 96.3 1.5E-05 1.5E-09 88.2 0.0 169 543-721 204-403 (651) 176 3TT9_A Plakophilin-2; CELL ADH 96.3 1.5E-05 1.7E-09 72.9 0.0 113 246-360 95-230 (233) 177 5D5K_C Importin subunit alpha- 96.3 1.5E-05 1.8E-09 79.2 0.0 113 246-359 273-386 (466) 178 4UAF_B Importin alpha 1 import 96.3 1.6E-05 1.8E-09 79.1 0.0 113 246-359 273-386 (466) 179 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 96.2 1.8E-05 2.2E-09 78.4 0.0 134 246-380 235-371 (450) 180 3IFQ_A plakoglobin, E-cadherin 96.2 1.8E-05 2.2E-09 80.6 0.0 367 245-716 145-534 (553) 181 4BQK_A IMPORTIN SUBUNIT ALPHA- 96.2 1.9E-05 2.2E-09 78.5 0.0 116 245-360 172-287 (456) 182 4U5L_A deltaIBB-importin-alpha 96.2 2.2E-05 2.6E-09 76.7 0.0 115 245-360 180-294 (426) 183 4BPL_A IMPORTIN SUBUNIT ALPHA- 96.2 2.3E-05 2.7E-09 77.8 0.0 135 245-379 170-306 (454) 184 4MZ6_E Deoxyuridine 5'-triphos 96.1 2.6E-05 3.1E-09 79.0 0.0 113 246-359 317-430 (509) 185 5UMZ_B Importin subunit alpha- 96.1 2.6E-05 3.1E-09 79.0 0.0 113 246-359 317-430 (509) 186 4E4V_A Importin subunit alpha- 96.1 2.7E-05 3.1E-09 78.7 0.0 113 246-359 292-405 (485) 187 3GQ2_A General vesicular trans 96.1 3.4E-05 3.5E-09 85.2 0.0 176 543-726 56-255 (651) 188 3GRL_A General vesicular trans 96.1 3.4E-05 3.5E-09 85.2 0.0 176 543-726 56-255 (651) 189 4V3Q_A YIII_M4_AII; DE NOVO PR 96.0 3.4E-05 4E-09 69.7 0.0 112 246-358 135-246 (247) 190 4TNM_A Importin-alpha3 / MOS6; 96.0 3.5E-05 4E-09 79.5 0.0 136 245-380 245-382 (531) 191 4GMO_A Putative uncharacterize 95.9 5.4E-05 5.2E-09 85.2 0.0 94 245-339 34-129 (684) 192 4PLS_B Arm00010; PEPTIDE BINDI 95.9 4.9E-05 5.8E-09 69.4 0.0 134 246-380 86-221 (281) 193 5MFO_F YIIIM3AIII; Designed ar 95.9 5E-05 5.9E-09 65.8 0.0 112 246-358 89-200 (202) 194 2RU4_A Armadillo Repeat Protei 95.9 5.2E-05 6E-09 59.8 0.0 110 248-358 4-113 (115) 195 5AEI_B DESIGNED ARMADILLO REPE 95.9 5.1E-05 6.1E-09 69.5 0.0 114 246-360 47-160 (286) 196 5MFD_C YIIIM''6AII, Capsid dec 95.9 5.1E-05 6.1E-09 70.8 0.0 157 545-714 128-286 (328) 197 5MFO_E YIIIM3AIII; Designed ar 95.9 5.2E-05 6.2E-09 65.7 0.0 112 246-358 89-200 (202) 198 5D5K_C Importin subunit alpha- 95.8 5.5E-05 6.5E-09 74.9 0.0 158 544-714 138-302 (466) 199 1XQS_B HSPBP1 protein, Heat sh 95.8 5.9E-05 6.6E-09 71.4 0.0 116 246-362 109-225 (280) 200 4UAF_B Importin alpha 1 import 95.8 5.9E-05 7E-09 74.7 0.0 158 544-714 138-302 (466) 201 1XQR_A HspBP1 protein; armadil 95.8 6.4E-05 7E-09 72.7 0.0 116 246-362 125-241 (296) 202 6CRI_R Bone marrow stromal ant 95.8 6.2E-05 7.1E-09 78.2 0.0 151 547-721 414-577 (585) 203 6SA8_A ring-like DARPin-Armadi 95.8 6.8E-05 7.7E-09 80.4 0.0 136 245-381 262-399 (671) 204 5WBJ_A Regulatory-associated p 95.8 8.1E-05 7.9E-09 89.5 0.0 168 541-715 500-672 (1287) 205 5Z8H_A Adenomatous polyposis c 95.7 7.4E-05 8.5E-09 71.6 0.0 115 246-361 210-331 (339) 206 5WBK_A Regulatory-associated p 95.7 9.2E-05 9E-09 89.0 0.0 168 541-715 500-672 (1287) 207 6SA6_A DARPin-Armadillo fusion 95.7 8.4E-05 9.6E-09 73.2 0.0 135 245-380 241-377 (397) 208 2W3C_A GENERAL VESICULAR TRANS 95.6 0.00012 1.2E-08 79.1 0.0 136 246-382 9-168 (577) 209 6CRI_I Bone marrow stromal ant 95.6 0.0001 1.2E-08 74.8 0.0 106 244-360 72-177 (570) 210 1QBK_B STRUCTURE OF THE KARYOP 95.6 0.00011 1.3E-08 79.3 0.0 157 547-715 667-824 (890) 211 4P6Z_G BST2/tetherin, HIV-1 Vp 95.6 0.00012 1.3E-08 77.7 0.0 151 547-721 431-594 (627) 212 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 95.5 0.00014 1.6E-08 65.0 0.0 112 246-358 131-242 (243) 213 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 95.5 0.00014 1.6E-08 65.0 0.0 112 246-358 131-242 (243) 214 5EWP_B Uncharacterized protein 95.4 0.00015 1.7E-08 67.3 0.0 134 246-380 87-233 (252) 215 4V3Q_A YIII_M4_AII; DE NOVO PR 95.4 0.00017 2E-08 64.8 0.0 134 246-380 51-186 (247) 216 3GQ2_A General vesicular trans 95.3 0.00022 2.3E-08 78.3 0.0 135 246-381 123-265 (651) 217 3GRL_A General vesicular trans 95.3 0.00022 2.3E-08 78.3 0.0 135 246-381 123-265 (651) 218 5AFF_A SYMPORTIN 1, RIBOSOMAL 95.2 0.00026 2.6E-08 78.8 0.0 94 245-339 12-107 (654) 219 6QH5_B AP-2 complex subunit al 95.2 0.00023 2.7E-08 73.0 0.0 107 243-360 84-190 (592) 220 3C2G_A Sys-1 protein, Pop-1 8- 95.2 0.00033 2.8E-08 77.7 0.0 189 260-486 185-412 (619) 221 4FDD_A Transportin-1, RNA-bind 95.1 0.00028 3.3E-08 75.3 0.0 157 547-715 629-786 (852) 222 4P6Z_B BST2/tetherin, HIV-1 Vp 95.0 0.00031 3.6E-08 72.5 0.0 106 244-360 101-206 (600) 223 2JKT_A AP-2 COMPLEX SUBUNIT AL 95.0 0.00032 3.7E-08 73.5 0.0 144 547-714 441-590 (623) 224 5IZ8_A Adenomatous polyposis c 95.0 0.00036 4.1E-08 67.8 0.0 162 543-716 166-337 (354) 225 5IZA_A Adenomatous polyposis c 94.9 0.00036 4.1E-08 67.8 0.0 162 543-716 166-337 (354) 226 5YVI_A Transportin-1, RNA-bind 94.9 0.00036 4.3E-08 74.5 0.0 156 547-714 645-801 (868) 227 6QH7_A AP-2 complex subunit al 94.9 0.00038 4.3E-08 73.0 0.0 108 242-360 108-217 (621) 228 1B3U_A PROTEIN PHOSPHATASE PP2 94.9 0.0004 4.8E-08 70.1 0.0 146 547-712 441-586 (588) 229 4HM9_A Beta-catenin-like prote 94.8 0.00057 5.4E-08 75.0 0.0 161 543-716 241-424 (568) 230 6QH5_A AP-2 complex subunit al 94.8 0.00048 5.5E-08 72.2 0.0 144 548-715 442-591 (621) 231 5MFO_F YIIIM3AIII; Designed ar 94.7 0.00052 6.2E-08 58.9 0.0 134 246-380 47-182 (202) 232 5MFO_E YIIIM3AIII; Designed ar 94.7 0.00054 6.3E-08 58.8 0.0 134 246-380 47-182 (202) 233 4MFU_A Beta-catenin-like prote 94.6 0.00067 6.6E-08 72.8 0.0 161 543-716 163-346 (490) 234 2NYL_A Protein phosphatase 2, 94.6 0.00059 7.1E-08 68.5 0.0 145 548-712 436-580 (582) 235 4U2X_F eVP24, KPNA5C; eVP24, i 94.4 0.00082 9.5E-08 57.1 0.0 73 246-318 51-124 (175) 236 3SL9_B Catenin beta-1, B-cell 94.3 0.00082 9.5E-08 56.5 0.0 110 246-357 56-166 (167) 237 4I5L_D PP2A A alpha subunit (9 94.3 0.0008 9.6E-08 67.6 0.0 110 246-359 239-349 (584) 238 4U2X_E eVP24, KPNA5C; eVP24, i 94.3 0.00091 1E-07 56.8 0.0 73 246-318 51-124 (175) 239 4UQI_B AP-2 COMPLEX SUBUNIT AL 94.2 0.00095 1.1E-07 70.3 0.0 106 244-360 85-190 (657) 240 5KC2_B Phosphatidylinositol 3- 94.0 0.0013 1.4E-07 79.1 0.0 155 544-715 506-689 (1454) 241 3SL9_E Catenin beta-1, B-cell 94.0 0.0012 1.4E-07 55.4 0.0 110 246-357 56-166 (167) 242 3VWA_B Cytoplasmic export prot 93.8 0.0017 1.8E-07 68.9 0.0 150 546-714 379-529 (560) 243 5DFZ_B Vacuolar protein sortin 93.7 0.0018 1.8E-07 77.7 0.0 155 546-719 608-762 (1460) 244 6HWP_A A3_bGFPD; alphaRep, art 93.7 0.0016 1.9E-07 62.8 0.0 91 245-358 23-113 (409) 245 3TT9_A Plakophilin-2; CELL ADH 93.7 0.0017 1.9E-07 58.2 0.0 169 542-716 47-232 (233) 246 3VWA_A Cytoplasmic export prot 93.6 0.0019 2E-07 68.6 0.0 152 545-715 378-530 (560) 247 1XQR_A HspBP1 protein; armadil 93.6 0.0019 2.1E-07 61.7 0.0 122 257-380 52-177 (296) 248 1XQS_B HSPBP1 protein, Heat sh 93.4 0.0023 2.6E-07 59.7 0.0 123 257-380 36-161 (280) 249 5VOZ_P V-type proton ATPase ca 93.3 0.0027 2.7E-07 67.5 0.0 330 290-714 78-475 (478) 250 5D80_H V-type proton ATPase ca 93.3 0.0027 2.7E-07 67.5 0.0 330 290-714 78-475 (478) 251 1F59_B IMPORTIN BETA-1/FXFG NU 93.3 0.0024 2.8E-07 62.2 0.0 154 549-713 261-437 (442) 252 6XTE_A Importin-5, antipain; h 93.2 0.0025 2.9E-07 70.4 0.0 153 548-714 358-521 (1096) 253 4HXT_A De Novo Protein OR329; 93.2 0.0025 3E-07 56.2 0.0 134 246-380 87-222 (252) 254 5IFE_C Splicing factor 3B subu 93.2 0.0029 3E-07 75.0 0.0 153 548-714 932-1087(1304) 255 6AHD_1 Pre-mRNA-processing-spl 93.2 0.0029 3E-07 75.0 0.0 153 548-714 932-1087(1304) 256 6QH5_B AP-2 complex subunit al 93.1 0.0027 3.1E-07 64.6 0.0 146 548-714 428-573 (592) 257 6EN4_C Splicing factor 3B subu 92.9 0.0031 3.6E-07 67.4 0.0 154 548-714 480-635 (852) 258 6SA6_A DARPin-Armadillo fusion 92.9 0.0032 3.7E-07 61.0 0.0 112 246-358 284-395 (397) 259 6FT5_A A3_A3; alphaRep, artifi 92.9 0.0032 3.7E-07 60.7 0.0 91 245-358 23-113 (409) 260 3C5W_A PP2A A subunit, PP2A C; 92.9 0.0032 3.8E-07 54.7 0.0 146 548-713 86-231 (232) 261 4LAC_A Serine/threonine-protei 92.9 0.0033 3.8E-07 56.3 0.0 110 545-670 31-140 (258) 262 4FDD_A Transportin-1, RNA-bind 92.6 0.0039 4.6E-07 65.8 0.0 150 548-712 360-511 (852) 263 5NR4_A CLIP-associating protei 92.6 0.004 4.6E-07 54.4 0.0 148 548-715 53-200 (230) 264 3C5W_A PP2A A subunit, PP2A C; 92.5 0.0041 4.8E-07 53.9 0.0 107 548-670 8-114 (232) 265 6XU2_A Importin-5, antipain; h 92.5 0.0042 4.9E-07 68.8 0.0 152 548-713 377-539 (1115) 266 4LAC_A Serine/threonine-protei 92.5 0.0043 5E-07 55.5 0.0 146 548-713 112-257 (258) 267 6EN4_C Splicing factor 3B subu 92.5 0.0043 5E-07 66.2 0.0 147 547-714 675-823 (852) 268 1QBK_B STRUCTURE OF THE KARYOP 92.4 0.0043 5.1E-07 66.1 0.0 151 548-713 398-550 (890) 269 6CRI_I Bone marrow stromal ant 92.4 0.0043 5.1E-07 62.1 0.0 145 548-714 415-560 (570) 270 2RU4_B Armadillo Repeat Protei 92.4 0.0045 5.2E-07 45.3 0.0 71 287-358 12-82 (84) 271 4L7M_A Putative uncharacterize 92.3 0.0047 5.5E-07 55.6 0.0 75 545-625 35-109 (269) 272 5WBJ_A Regulatory-associated p 92.2 0.0059 5.8E-07 72.7 0.0 100 561-671 612-725 (1287) 273 5WBK_A Regulatory-associated p 92.2 0.0059 5.8E-07 72.7 0.0 101 560-671 611-725 (1287) 274 2QK2_A LP04448p; Mini spindles 92.2 0.005 5.8E-07 54.5 0.0 145 548-714 16-163 (242) 275 3W3U_A Importin subunit beta-3 92.2 0.005 5.8E-07 67.5 0.0 115 245-360 397-512 (1078) 276 2IW3_B ELONGATION FACTOR 3A; A 92.0 0.0058 6.5E-07 68.1 0.0 148 548-713 176-324 (986) 277 4G3A_B CLIP-associating protei 91.9 0.0059 6.8E-07 54.0 0.0 150 547-714 7-158 (237) 278 5EWP_B Uncharacterized protein 91.9 0.0062 6.9E-07 55.7 0.0 176 528-716 7-209 (252) 279 4QMI_B Cytoskeleton-associated 91.9 0.006 6.9E-07 54.1 0.0 147 548-715 60-208 (240) 280 4QMJ_A Cytoskeleton-associated 91.9 0.006 6.9E-07 54.1 0.0 147 548-715 60-208 (240) 281 5XAH_A Importin-4; Histone, Ch 91.8 0.0062 7.2E-07 58.5 0.0 153 548-714 235-389 (416) 282 5XAH_C Importin-4; Histone, Ch 91.8 0.0062 7.2E-07 58.5 0.0 153 548-714 235-389 (416) 283 2QK1_A Protein STU2; stu2, Stu 91.8 0.0063 7.3E-07 53.8 0.0 152 548-714 17-176 (249) 284 5H2V_A Importin subunit beta-3 91.8 0.0063 7.4E-07 66.7 0.0 114 246-360 398-512 (1078) 285 6OWT_A AP-2 complex subunit al 91.7 0.0072 7.8E-07 67.7 0.0 142 548-713 442-589 (939) 286 2P8Q_A Importin beta-1 subunit 91.7 0.0066 7.8E-07 64.5 0.0 160 548-715 650-829 (876) 287 5MFO_F YIIIM3AIII; Designed ar 91.6 0.0068 8E-07 51.3 0.0 157 546-715 3-161 (202) 288 5MFO_E YIIIM3AIII; Designed ar 91.6 0.007 8.3E-07 51.2 0.0 157 546-715 3-161 (202) 289 2QNA_A Importin subunit beta-1 91.5 0.0073 8.6E-07 62.8 0.0 159 548-714 525-703 (762) 290 6G4J_B Probable serine/threoni 91.5 0.008 8.8E-07 50.6 0.0 132 548-723 15-146 (148) 291 3W3W_A Importin subunit beta-3 91.3 0.0081 9.5E-07 65.7 0.0 98 609-715 821-920 (1078) 292 3ND2_A Importin subunit beta-1 91.2 0.0083 9.8E-07 63.2 0.0 152 548-713 598-763 (861) 293 5OWU_A Importin subunit beta-1 91.2 0.0083 9.8E-07 63.2 0.0 152 548-713 598-763 (861) 294 5DFZ_B Vacuolar protein sortin 91.0 0.011 1.1E-06 70.6 0.0 159 546-714 463-639 (1460) 295 3W3U_A Importin subunit beta-3 90.7 0.011 1.3E-06 64.7 0.0 157 548-713 440-600 (1078) 296 1QGR_A IMPORTIN BETA SUBUNIT, 90.6 0.011 1.3E-06 62.8 0.0 113 246-360 367-480 (876) 297 4QMH_A LP04448p; PROTEIN BINDI 90.4 0.012 1.4E-06 51.8 0.0 149 548-715 58-209 (241) 298 5A1V_E ADP-RIBOSYLATION FACTOR 90.4 0.013 1.4E-06 64.9 0.0 102 244-359 67-168 (874) 299 5NZR_G Coatomer subunit alpha, 90.4 0.013 1.4E-06 64.9 0.0 102 244-359 67-168 (874) 300 3W3W_A Importin subunit beta-3 90.3 0.013 1.5E-06 64.1 0.0 157 547-714 439-601 (1078) 301 5H2V_A Importin subunit beta-3 90.2 0.013 1.5E-06 64.0 0.0 158 547-714 439-601 (1078) 302 4NEE_G AP-2 complex subunit si 90.1 0.014 1.6E-06 56.7 0.0 141 548-714 77-219 (398) 303 6MQ5_A CLIP-associating protei 90.0 0.015 1.7E-06 52.9 0.0 111 548-670 4-120 (257) 304 4UQI_B AP-2 COMPLEX SUBUNIT AL 90.0 0.015 1.7E-06 60.6 0.0 109 245-359 160-268 (657) 305 4XRI_A Importin Beta; Transpor 89.9 0.014 1.7E-06 61.5 0.0 159 548-715 651-826 (882) 306 4NEE_B AP-2 complex subunit si 89.8 0.016 1.8E-06 56.6 0.0 141 548-714 77-219 (398) 307 6EN4_C Splicing factor 3B subu 89.8 0.015 1.8E-06 61.6 0.0 153 548-714 397-551 (852) 308 5A1V_E ADP-RIBOSYLATION FACTOR 89.6 0.018 1.9E-06 63.8 0.0 141 548-714 397-538 (874) 309 5NZR_G Coatomer subunit alpha, 89.6 0.018 1.9E-06 63.8 0.0 141 548-714 397-538 (874) 310 6OWT_A AP-2 complex subunit al 89.5 0.018 2E-06 64.2 0.0 98 250-360 79-178 (939) 311 5KC2_B Phosphatidylinositol 3- 89.3 0.021 2.1E-06 68.3 0.0 151 548-714 424-610 (1454) 312 2P8Q_A Importin beta-1 subunit 89.3 0.018 2.1E-06 60.9 0.0 154 548-714 367-538 (876) 313 2QNA_A Importin subunit beta-1 89.1 0.019 2.3E-06 59.4 0.0 115 245-360 3-122 (762) 314 1IBR_B RAN IMPORTIN BETA SUBU 89.1 0.019 2.3E-06 55.6 0.0 154 548-714 129-289 (462) 315 1QGR_A IMPORTIN BETA SUBUNIT, 88.9 0.021 2.4E-06 60.6 0.0 154 548-714 367-538 (876) 316 2DB0_A 253aa long hypothetical 88.9 0.021 2.4E-06 50.5 0.0 141 548-715 108-248 (253) 317 2DB0_B 253aa long hypothetical 88.9 0.021 2.4E-06 50.5 0.0 141 548-715 108-248 (253) 318 4K92_B CLIP-associating protei 88.8 0.022 2.5E-06 52.5 0.0 148 548-714 90-237 (273) 319 6MQ7_B CLIP-associating protei 88.8 0.022 2.5E-06 52.5 0.0 148 548-714 90-237 (273) 320 1GCJ_B IMPORTIN-BETA; HEAT REP 88.7 0.022 2.5E-06 55.4 0.0 154 548-714 135-295 (460) 321 1F59_B IMPORTIN BETA-1/FXFG NU 88.7 0.022 2.6E-06 54.8 0.0 154 548-714 129-289 (442) 322 1UKL_A Importin beta-1 subunit 88.6 0.022 2.6E-06 60.2 0.0 113 246-360 367-480 (876) 323 1U6G_C Cullin homolog 1, RING- 88.2 0.025 2.9E-06 62.9 0.0 146 548-714 891-1036(1230) 324 4MFU_A Beta-catenin-like prote 88.1 0.031 3.1E-06 59.1 0.0 135 246-381 69-222 (490) 325 6CRI_I Bone marrow stromal ant 87.6 0.03 3.5E-06 55.5 0.0 141 548-714 37-177 (570) 326 3QML_D 78 kDa glucose-regulate 87.5 0.038 3.6E-06 55.4 0.0 165 534-712 56-246 (315) 327 5IFE_C Splicing factor 3B subu 87.4 0.036 3.7E-06 65.2 0.0 154 547-714 848-1003(1304) 328 6AHD_1 Pre-mRNA-processing-spl 87.4 0.036 3.7E-06 65.2 0.0 154 547-714 848-1003(1304) 329 5MU7_A Coatomer subunit beta, 87.4 0.031 3.7E-06 52.4 0.0 141 549-716 190-331 (373) 330 5VE8_B Kap123, Histone H3; Bid 87.4 0.031 3.7E-06 61.1 0.0 154 549-714 868-1034(1116) 331 2IX8_A ELONGATION FACTOR 3A; N 87.3 0.034 3.8E-06 61.3 0.0 150 547-713 48-198 (976) 332 3WOY_A CLIP-associating protei 87.3 0.034 3.8E-06 50.1 0.0 147 548-714 78-225 (251) 333 5DN7_A Protein FAM179B; TOG do 87.2 0.035 3.9E-06 52.0 0.0 146 548-714 67-212 (293) 334 4HM9_A Beta-catenin-like prote 87.2 0.04 3.9E-06 59.6 0.0 135 246-381 147-300 (568) 335 6S47_Bi 60S ribosomal protein 87.2 0.035 3.9E-06 61.2 0.0 155 546-713 42-198 (972) 336 6QH5_B AP-2 complex subunit al 87.1 0.034 4E-06 55.8 0.0 142 548-715 50-191 (592) 337 5A1V_G ADP-RIBOSYLATION FACTOR 87.1 0.037 4E-06 61.9 0.0 105 547-670 259-364 (968) 338 3TJZ_B ADP-ribosylation factor 87.0 0.036 4.1E-06 52.5 0.0 16 697-712 225-240 (355) 339 2IW3_B ELONGATION FACTOR 3A; A 86.9 0.037 4.1E-06 61.1 0.0 151 547-714 54-205 (986) 340 5NZR_B Coatomer subunit alpha, 86.8 0.04 4.3E-06 61.6 0.0 105 547-670 259-364 (968) 341 4P6Z_B BST2/tetherin, HIV-1 Vp 86.8 0.037 4.3E-06 55.9 0.0 142 548-715 66-207 (600) 342 5VCH_A Kap123; Bidding yeast k 86.7 0.038 4.4E-06 60.5 0.0 153 550-714 869-1034(1116) 343 6BCU_A mTOR, Target of rapamyc 86.7 0.04 4.4E-06 67.9 0.0 131 549-694 952-1084(2549) 344 6BCX_B mTOR, Target of rapamyc 86.7 0.04 4.4E-06 67.9 0.0 131 549-694 952-1084(2549) 345 5IFE_C Splicing factor 3B subu 86.4 0.045 4.7E-06 64.2 0.0 110 249-359 935-1044(1304) 346 6AHD_1 Pre-mRNA-processing-spl 86.4 0.045 4.7E-06 64.2 0.0 110 249-359 935-1044(1304) 347 6LTJ_L Histone H3.2, Histone H 86.4 0.056 4.7E-06 63.5 0.0 152 563-723 1065-1263(1295) 348 6CRI_R Bone marrow stromal ant 86.2 0.043 4.9E-06 55.5 0.0 139 548-714 63-201 (585) 349 5DFZ_B Vacuolar protein sortin 85.9 0.051 5.3E-06 64.4 0.0 292 245-645 464-781 (1460) 350 2QNA_A Importin subunit beta-1 85.8 0.046 5.4E-06 56.3 0.0 154 548-714 4-164 (762) 351 3WOZ_C CLIP-associating protei 85.7 0.049 5.4E-06 48.6 0.0 154 547-716 5-159 (232) 352 3WOZ_D CLIP-associating protei 85.7 0.049 5.4E-06 48.6 0.0 154 547-716 5-159 (232) 353 5DCQ_C artificial repeat prote 85.5 0.051 5.7E-06 45.4 0.0 47 654-712 120-166 (170) 354 4L7M_A Putative uncharacterize 85.3 0.051 6E-06 48.1 0.0 143 548-713 120-265 (269) 355 4P6Z_B BST2/tetherin, HIV-1 Vp 85.1 0.053 6.2E-06 54.6 0.0 109 245-359 176-284 (600) 356 5MU7_A Coatomer subunit beta, 85.1 0.053 6.2E-06 50.7 0.0 101 598-714 191-292 (373) 357 4UQI_B AP-2 COMPLEX SUBUNIT AL 85.0 0.056 6.3E-06 55.9 0.0 142 548-715 50-191 (657) 358 6MZE_Z Tubulin alpha-1A chain, 84.9 0.055 6.4E-06 53.4 0.0 149 548-715 340-496 (536) 359 4MFU_A Beta-catenin-like prote 84.8 0.067 6.5E-06 56.4 0.0 117 610-733 42-175 (490) 360 5N3U_B Phycocyanobilin lyase s 84.6 0.06 6.9E-06 46.1 0.0 135 547-714 32-167 (208) 361 6QH5_B AP-2 complex subunit al 84.4 0.06 7E-06 53.8 0.0 145 548-713 122-268 (592) 362 2DB0_A 253aa long hypothetical 84.4 0.062 7.1E-06 47.2 0.0 104 547-670 32-136 (253) 363 2DB0_B 253aa long hypothetical 84.4 0.062 7.1E-06 47.2 0.0 104 547-670 32-136 (253) 364 2JKT_A AP-2 COMPLEX SUBUNIT AL 84.2 0.064 7.3E-06 54.8 0.0 140 548-713 75-216 (623) 365 3LTJ_A AlphaRep-4; protein eng 84.1 0.065 7.5E-06 45.7 0.0 28 685-713 140-167 (201) 366 4P6Z_B BST2/tetherin, HIV-1 Vp 84.1 0.065 7.5E-06 54.0 0.0 145 548-713 138-284 (600) 367 6QH7_A AP-2 complex subunit al 84.0 0.067 7.6E-06 54.8 0.0 140 548-713 75-216 (621) 368 6CRI_R Bone marrow stromal ant 83.9 0.067 7.7E-06 53.9 0.0 67 548-625 135-201 (585) 369 4UQI_B AP-2 COMPLEX SUBUNIT AL 83.9 0.069 7.8E-06 55.2 0.0 145 548-713 122-268 (657) 370 5XAH_A Importin-4; Histone, Ch 83.5 0.071 8.2E-06 50.5 0.0 142 561-715 163-307 (416) 371 5XAH_C Importin-4; Histone, Ch 83.5 0.071 8.2E-06 50.5 0.0 142 561-715 163-307 (416) 372 5FRS_A SISTER CHROMATID COHESI 83.5 0.08 8.3E-06 57.5 0.0 149 548-715 282-431 (703) 373 4HM9_A Beta-catenin-like prote 83.5 0.087 8.3E-06 56.8 0.0 136 246-381 198-350 (568) 374 5FRP_A SISTER CHROMATID COHESI 83.4 0.082 8.4E-06 57.5 0.0 149 548-715 282-431 (703) 375 5GM6_G Prp8, Brr2, Snu114, Rse 83.4 0.077 8.4E-06 58.7 0.0 69 248-316 603-671 (971) 376 5ZWM_1 Pre-mRNA-splicing facto 83.4 0.077 8.4E-06 58.7 0.0 69 248-316 603-671 (971) 377 3TJZ_B ADP-ribosylation factor 83.4 0.075 8.5E-06 50.1 0.0 102 596-712 251-352 (355) 378 6CRI_R Bone marrow stromal ant 83.3 0.075 8.6E-06 53.5 0.0 101 246-359 100-200 (585) 379 6U62_A Regulatory-associated p 83.0 0.095 9E-06 62.5 0.0 159 544-715 468-630 (1392) 380 6BCX_W mTOR, Target of rapamyc 82.8 0.098 9.3E-06 62.1 0.0 159 544-715 476-638 (1343) 381 4QMH_A LP04448p; PROTEIN BINDI 82.8 0.081 9.4E-06 46.0 0.0 114 595-716 17-130 (241) 382 6QH5_A AP-2 complex subunit al 82.8 0.083 9.4E-06 54.0 0.0 140 548-713 75-216 (621) 383 6EMK_C Serine/threonine-protei 82.8 0.086 9.4E-06 64.9 0.0 71 548-625 922-993 (2474) 384 5MU7_A Coatomer subunit beta, 82.7 0.082 9.5E-06 49.3 0.0 71 548-624 39-110 (373) 385 6CRI_I Bone marrow stromal ant 82.7 0.081 9.6E-06 52.1 0.0 145 548-713 109-255 (570) 386 4QMI_B Cytoskeleton-associated 82.6 0.084 9.7E-06 46.0 0.0 112 595-715 19-131 (240) 387 4QMJ_A Cytoskeleton-associated 82.6 0.084 9.7E-06 46.0 0.0 112 595-715 19-131 (240) 388 6MZG_E Tubulin alpha-1A chain, 82.5 0.084 9.8E-06 52.4 0.0 147 549-715 315-466 (554) 389 1B3U_A PROTEIN PHOSPHATASE PP2 82.3 0.085 1E-05 51.8 0.0 147 547-713 164-310 (588) 390 2OF3_A ZYG-9; Multifunctional 82.0 0.098 1.1E-05 48.1 0.0 150 548-714 88-237 (266) 391 4I5L_D PP2A A alpha subunit (9 81.8 0.092 1.1E-05 51.5 0.0 147 547-713 160-306 (584) 392 4Y5J_A Mini spindles TOG3; XMA 81.7 0.097 1.1E-05 46.2 0.0 71 548-625 15-89 (248) 393 4P6Z_G BST2/tetherin, HIV-1 Vp 81.6 0.1 1.1E-05 53.7 0.0 137 549-713 81-217 (627) 394 5KC2_B Phosphatidylinositol 3- 81.5 0.11 1.2E-05 61.5 0.0 126 247-379 621-746 (1454) 395 6MZG_E Tubulin alpha-1A chain, 81.1 0.1 1.2E-05 51.7 0.0 151 550-714 57-211 (554) 396 6MZE_Z Tubulin alpha-1A chain, 81.1 0.1 1.2E-05 51.2 0.0 108 600-714 300-412 (536) 397 6RXU_UJ Periodic tryptophan pr 80.9 0.12 1.2E-05 62.5 0.0 152 548-713 1625-1791(1802) 398 5FVM_B SERINE/THREONINE-PROTEI 80.8 0.12 1.3E-05 63.5 0.0 147 548-714 1008-1155(2471) 399 6GWC_C Tubulin alpha chain, Tu 80.7 0.11 1.3E-05 45.3 0.0 49 654-714 120-168 (232) 400 1OYZ_A X-RAY STRUCTURE OF YB61 80.6 0.11 1.3E-05 46.1 0.0 64 549-623 92-156 (280) 401 6GX7_F Tubulin alpha chain, Tu 80.5 0.12 1.3E-05 44.1 0.0 122 548-713 46-167 (201) 402 2NYL_A Protein phosphatase 2, 80.4 0.11 1.3E-05 50.7 0.0 147 547-713 158-304 (582) 403 5VJC_B Protein mini spindles; 80.3 0.12 1.4E-05 47.2 0.0 72 547-625 50-121 (271) 404 6RXV_UJ Periodic tryptophan pr 80.3 0.13 1.4E-05 62.1 0.0 152 548-713 1625-1791(1802) 405 4I5L_D PP2A A alpha subunit (9 80.2 0.11 1.4E-05 50.8 0.0 109 547-670 238-349 (584) 406 1IBR_B RAN IMPORTIN BETA SUBU 80.2 0.12 1.4E-05 49.6 0.0 156 549-716 261-440 (462) 407 1B3U_A PROTEIN PHOSPHATASE PP2 80.1 0.12 1.4E-05 50.8 0.0 109 547-670 242-353 (588) 408 4P6Z_G BST2/tetherin, HIV-1 Vp 80.0 0.13 1.4E-05 52.9 0.0 67 548-625 152-218 (627) 409 5NR4_A CLIP-associating protei 80.0 0.12 1.4E-05 44.1 0.0 109 244-360 51-159 (230) 410 2P8Q_A Importin beta-1 subunit 79.9 0.12 1.4E-05 54.0 0.0 154 548-714 129-289 (876) 411 4I5L_D PP2A A alpha subunit (9 79.9 0.12 1.4E-05 50.6 0.0 147 547-713 320-466 (584) 412 1QGR_A IMPORTIN BETA SUBUNIT, 79.8 0.12 1.4E-05 54.2 0.0 154 548-714 129-289 (876) 413 1B3U_A PROTEIN PHOSPHATASE PP2 79.8 0.12 1.5E-05 50.6 0.0 146 547-712 324-469 (588) 414 6MZE_Z Tubulin alpha-1A chain, 79.7 0.13 1.5E-05 50.5 0.0 152 550-715 57-212 (536) 415 5F0N_A cohesin subunit Pds5, K 79.1 0.17 1.6E-05 59.2 0.0 150 547-714 271-420 (1175) 416 4NEE_G AP-2 complex subunit si 78.8 0.15 1.7E-05 48.9 0.0 115 548-671 149-273 (398) 417 3W3U_A Importin subunit beta-3 78.8 0.14 1.7E-05 55.2 0.0 158 548-714 849-1007(1078) 418 4NEE_B AP-2 complex subunit si 78.7 0.15 1.7E-05 49.0 0.0 115 548-671 149-273 (398) 419 3DAD_A FH1/FH2 domain-containi 78.5 0.18 1.7E-05 50.5 0.0 154 565-729 135-309 (339) 420 5VJC_A Protein mini spindles; 78.4 0.16 1.7E-05 46.5 0.0 73 546-625 49-121 (271) 421 5WBJ_A Regulatory-associated p 78.3 0.18 1.8E-05 59.3 0.0 156 548-716 467-631 (1287) 422 5WBK_A Regulatory-associated p 78.3 0.18 1.8E-05 59.3 0.0 156 548-716 467-631 (1287) 423 6EN4_C Splicing factor 3B subu 78.2 0.15 1.8E-05 53.3 0.0 154 548-715 192-347 (852) 424 5F0O_A cohesin subunit Pds5, K 78.2 0.18 1.8E-05 58.5 0.0 150 547-714 280-429 (1133) 425 2NYL_A Protein phosphatase 2, 77.8 0.16 1.9E-05 49.5 0.0 109 547-670 236-347 (582) 426 3W3W_A Importin subunit beta-3 77.6 0.16 1.9E-05 54.7 0.0 157 548-714 849-1007(1078) 427 4LAC_A Serine/threonine-protei 77.5 0.17 1.9E-05 44.2 0.0 115 239-360 27-141 (258) 428 6FT5_A A3_A3; alphaRep, artifi 77.5 0.17 1.9E-05 47.7 0.0 60 547-623 54-113 (409) 429 1F59_B IMPORTIN BETA-1/FXFG NU 77.4 0.17 2E-05 48.1 0.0 158 547-714 35-204 (442) 430 2NYL_A Protein phosphatase 2, 77.3 0.16 2E-05 49.4 0.0 70 547-625 318-387 (582) 431 5FVM_B SERINE/THREONINE-PROTEI 77.2 0.18 2E-05 61.6 0.0 71 548-625 925-996 (2471) 432 3LTJ_A AlphaRep-4; protein eng 77.2 0.18 2E-05 42.7 0.0 121 548-712 77-197 (201) 433 5JO8_A CEP104; centriolar prot 77.2 0.18 2E-05 46.5 0.0 155 548-714 87-245 (279) 434 4P6Z_G BST2/tetherin, HIV-1 Vp 77.2 0.18 2E-05 51.7 0.0 101 246-359 117-217 (627) 435 1GCJ_B IMPORTIN-BETA; HEAT REP 77.2 0.17 2E-05 48.4 0.0 154 549-714 267-444 (460) 436 6GWC_C Tubulin alpha chain, Tu 76.9 0.18 2.1E-05 43.9 0.0 121 548-712 108-228 (232) 437 3QML_D 78 kDa glucose-regulate 76.8 0.22 2.1E-05 49.4 0.0 104 609-717 42-154 (315) 438 4G3A_B CLIP-associating protei 76.8 0.18 2.1E-05 43.5 0.0 113 244-358 6-118 (237) 439 6IDX_A Engulfment and cell mot 76.8 0.22 2.1E-05 52.8 0.0 157 563-731 102-272 (524) 440 6IE1_A Engulfment and cell mot 76.8 0.22 2.1E-05 52.8 0.0 157 563-731 102-272 (524) 441 5H2V_A Importin subunit beta-3 76.6 0.18 2.1E-05 54.2 0.0 157 548-714 849-1007(1078) 442 1TE4_A conserved protein MTH18 76.5 0.19 2.2E-05 39.5 0.0 118 548-710 13-130 (131) 443 6S47_Bi 60S ribosomal protein 76.5 0.2 2.2E-05 54.8 0.0 155 548-714 127-321 (972) 444 1OYZ_A X-RAY STRUCTURE OF YB61 76.4 0.19 2.2E-05 44.5 0.0 96 596-712 91-187 (280) 445 5NR4_A CLIP-associating protei 76.2 0.19 2.2E-05 42.7 0.0 111 595-713 6-122 (230) 446 5A1V_E ADP-RIBOSYLATION FACTOR 75.9 0.22 2.3E-05 54.5 0.0 137 548-713 69-205 (874) 447 5NZR_G Coatomer subunit alpha, 75.9 0.22 2.3E-05 54.5 0.0 137 548-713 69-205 (874) 448 6HWP_A A3_bGFPD; alphaRep, art 75.5 0.21 2.4E-05 46.8 0.0 49 654-714 129-177 (409) 449 3W3U_A Importin subunit beta-3 75.5 0.21 2.4E-05 53.8 0.0 152 549-714 358-512 (1078) 450 4QMI_B Cytoskeleton-associated 75.5 0.21 2.4E-05 43.2 0.0 107 245-360 59-167 (240) 451 4QMJ_A Cytoskeleton-associated 75.5 0.21 2.4E-05 43.2 0.0 107 245-360 59-167 (240) 452 2IX8_A ELONGATION FACTOR 3A; N 75.4 0.22 2.4E-05 54.3 0.0 153 548-713 128-318 (976) 453 5XAH_A Importin-4; Histone, Ch 75.4 0.21 2.4E-05 46.9 0.0 162 548-713 33-222 (416) 454 5XAH_C Importin-4; Histone, Ch 75.4 0.21 2.4E-05 46.9 0.0 162 548-713 33-222 (416) 455 5H2V_A Importin subunit beta-3 75.1 0.22 2.5E-05 53.6 0.0 154 548-714 357-512 (1078) 456 6OWT_A AP-2 complex subunit al 75.0 0.24 2.6E-05 54.6 0.0 140 548-713 75-216 (939) 457 4G3A_B CLIP-associating protei 74.9 0.22 2.6E-05 42.9 0.0 107 548-671 91-198 (237) 458 4XL5_C Green fluorescent prote 74.6 0.23 2.7E-05 43.8 0.0 121 548-712 139-259 (263) 459 4FDD_A Transportin-1, RNA-bind 74.5 0.23 2.7E-05 51.3 0.0 155 548-714 129-286 (852) 460 4D4Z_A DEOXYHYPUSINE HYDROXYLA 74.4 0.23 2.7E-05 44.2 0.0 124 546-711 9-134 (294) 461 4D50_A DEOXYHYPUSINE HYDROXYLA 74.4 0.23 2.7E-05 44.2 0.0 124 546-711 9-134 (294) 462 6QH5_A AP-2 complex subunit al 74.2 0.24 2.8E-05 50.3 0.0 69 548-625 147-217 (621) 463 5LPH_B Centrosomal protein of 74.0 0.26 2.8E-05 45.9 0.0 155 549-714 94-251 (288) 464 1QBK_B STRUCTURE OF THE KARYOP 73.9 0.24 2.8E-05 51.6 0.0 156 548-715 129-287 (890) 465 3W3W_A Importin subunit beta-3 73.9 0.24 2.9E-05 53.2 0.0 153 548-714 357-512 (1078) 466 1IBR_B RAN IMPORTIN BETA SUBU 73.6 0.25 2.9E-05 47.1 0.0 158 547-714 35-204 (462) 467 5VCH_A Kap123; Bidding yeast k 73.4 0.26 3E-05 53.4 0.0 153 548-714 361-516 (1116) 468 6QH7_A AP-2 complex subunit al 73.4 0.26 3E-05 50.0 0.0 69 548-625 147-217 (621) 469 2JKT_A AP-2 COMPLEX SUBUNIT AL 73.3 0.27 3E-05 49.9 0.0 69 548-625 147-217 (623) 470 1GCJ_B IMPORTIN-BETA; HEAT REP 73.0 0.27 3.1E-05 47.0 0.0 158 547-714 41-210 (460) 471 1OYZ_A X-RAY STRUCTURE OF YB61 73.0 0.27 3.1E-05 43.4 0.0 121 547-710 159-279 (280) 472 2JKT_A AP-2 COMPLEX SUBUNIT AL 72.8 0.28 3.2E-05 49.7 0.0 67 548-623 330-397 (623) 473 5VE8_B Kap123, Histone H3; Bid 72.7 0.27 3.2E-05 53.1 0.0 153 548-714 361-516 (1116) 474 4ZV6_A AlphaRep-7, Octarellin 71.7 0.3 3.5E-05 43.7 0.0 29 685-714 140-168 (294) 475 6BZX_A alpha-Rep, Octarellin V 71.4 0.31 3.6E-05 43.6 0.0 29 685-714 140-168 (294) 476 5IFE_C Splicing factor 3B subu 70.4 0.38 3.9E-05 55.8 0.0 154 548-715 644-799 (1304) 477 6AHD_1 Pre-mRNA-processing-spl 70.4 0.38 3.9E-05 55.8 0.0 154 548-715 644-799 (1304) 478 2QK2_A LP04448p; Mini spindles 70.3 0.34 4E-05 41.6 0.0 113 243-358 13-126 (242) 479 6MZG_E Tubulin alpha-1A chain, 70.0 0.35 4.1E-05 47.5 0.0 71 549-625 138-211 (554) 480 6QH7_A AP-2 complex subunit al 69.9 0.36 4.1E-05 48.9 0.0 100 247-359 76-177 (621) 481 1UKL_A Importin beta-1 subunit 69.9 0.35 4.1E-05 50.3 0.0 154 548-714 129-289 (876) 482 6EMK_C Serine/threonine-protei 69.9 0.38 4.1E-05 58.8 0.0 136 562-714 1016-1152(2474) 483 4XL5_C Green fluorescent prote 69.9 0.36 4.1E-05 42.4 0.0 49 654-714 120-168 (263) 484 4D4Z_A DEOXYHYPUSINE HYDROXYLA 69.8 0.36 4.1E-05 42.9 0.0 127 547-715 161-289 (294) 485 4D50_A DEOXYHYPUSINE HYDROXYLA 69.8 0.36 4.1E-05 42.9 0.0 127 547-715 161-289 (294) 486 6QH5_A AP-2 complex subunit al 69.7 0.37 4.2E-05 48.8 0.0 67 548-623 330-397 (621) 487 4XL5_C Green fluorescent prote 69.5 0.37 4.2E-05 42.3 0.0 88 600-714 143-230 (263) 488 6LTJ_L Histone H3.2, Histone H 69.2 0.52 4.4E-05 55.1 0.0 106 609-716 1064-1189(1295) 489 5WLC_LM rpS18_uS13, rpS4_eS4, 69.1 0.44 4.4E-05 57.4 0.0 153 548-713 1597-1758(1769) 490 5YVI_A Transportin-1, RNA-bind 69.1 0.37 4.4E-05 49.7 0.0 155 548-714 131-288 (868) 491 3VWA_A Cytoplasmic export prot 68.9 0.42 4.5E-05 49.3 0.0 111 594-715 340-450 (560) 492 3VWA_B Cytoplasmic export prot 68.9 0.42 4.5E-05 49.2 0.0 111 594-715 340-450 (560) 493 3C5W_A PP2A A subunit, PP2A C; 68.8 0.38 4.5E-05 40.3 0.0 109 245-360 7-115 (232) 494 4K92_B CLIP-associating protei 68.6 0.41 4.6E-05 43.1 0.0 109 244-360 129-237 (273) 495 6MQ7_B CLIP-associating protei 68.6 0.41 4.6E-05 43.1 0.0 109 244-360 129-237 (273) 496 4LAC_A Serine/threonine-protei 68.3 0.41 4.7E-05 41.4 0.0 109 245-360 111-219 (258) 497 6MQ5_A CLIP-associating protei 68.0 0.43 4.8E-05 42.3 0.0 108 245-360 49-157 (257) 498 2QK1_A Protein STU2; stu2, Stu 67.9 0.42 4.9E-05 40.9 0.0 116 244-360 103-221 (249) 499 4D4Z_A DEOXYHYPUSINE HYDROXYLA 67.6 0.43 5E-05 42.3 0.0 60 547-623 74-135 (294) 500 4D50_A DEOXYHYPUSINE HYDROXYLA 67.6 0.43 5E-05 42.3 0.0 60 547-623 74-135 (294) No 1 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=99.69 E-value=6.3e-22 Score=206.93 Aligned_cols=453 Identities=100% Similarity=1.422 Sum_probs=304.9 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) .++.+..++.+.++.++..++.+|..++...+.....+...++++.+..++.+.+..++..++.++.+++.........+ T Consensus 3 ~l~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~ 82 (457) T 1XM9_A 3 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 82 (457) T ss_dssp CHHHHHHHHHSSCTHHHHHHHHHHHHHTSSCSSHHHHHHHTTHHHHHHHHTTSSCHHHHHHHHHHHHHHHSSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHH Confidence 45566777777778889999999999885444444445555778888888888788899999999999886544333444 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFN 405 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~ 405 (747) ...+.++.++.++....+..++..++.+|.+++........+..++++.|+.++..+.++|+.+.+.+.....++++... T Consensus 83 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~ 162 (457) T 1XM9_A 83 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFN 162 (457) T ss_dssp HHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSSSTHHHHHHHHHHHCCCCCCHHHHTCC---------CCCHHHHHH T ss_pred HhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCHHHHHHHHcchHHHHHHHhccccCCCCCCCCCcccccCCHHHHHH Confidence 44567777777775344677888899999999875444333335788999999999999999988887777777777766 Q NP_000290.2 406 ATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYR 485 (747) Q Consensus 406 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 485 (747) +..+|.. +...+..++.+....|+++.|+.+++.+......+..-.+.+..+|.|++.. T Consensus 163 a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~l~~l~~~ 221 (457) T 1XM9_A 163 ATGCLRN---------------------LSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYR 221 (457) T ss_dssp HHHHHHH---------------------HTTSHHHHHHHTTSTTHHHHHHHHHHHHHHHTCTTCTTHHHHHHHHHHHTTT T ss_pred HHHHHHH---------------------HccChHHHHHHHhcccHHHHHHHHHHHhhhcCcCCHHHHHHHHHHHHHHhcc Confidence 6665543 2222223444555567788888887765555556777888999999999999 Q NP_000290.2 486 LDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATL 565 (747) Q Consensus 486 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr 565 (747) .+.+.+..+..+++.++..+..+...+|+.+...+++....+|.++....+......+.+.++++.++.++....+..++ T Consensus 222 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~ 301 (457) T 1XM9_A 222 LDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATL 301 (457) T ss_dssp HHHHSCCHHHHHHHTC----------------------------CCCCCSSCCGGGGGGSHHHHHHHHHHHHHCCCHHHH T ss_pred cccCCCcchhhhhhcccccccccccccccCcccchhccccccCCCCcccCCCchhHHhhchhHHHHHHHHhccCCCHHHH Confidence 99999999999999999999999999999999999999999999998888888888888999999999999733556777 Q NP_000290.2 566 EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLT 645 (747) Q Consensus 566 ~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~ 645 (747) ..++.+|.+++..............+...++++.|+.++.+.++.++..++.+|.+++..+.....+..++++.++.++. T Consensus 302 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~l~~~l~ 381 (457) T 1XM9_A 302 EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLT 381 (457) T ss_dssp HHHHHHHHHHTTCSSSHHHHHHHCCCCCSCCHHHHHHHTTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHHTHHHHHHTTT T ss_pred HHHHHHHHHHHhccccccCCcchhhhhhcchHHHHHHHHhcCCHHHHHHHHHHHHHHhcCHHHHHHHHcccHHHHHHHHh Confidence 78999999998753200000002233456788999999988888999999999999996644432233347777777776 Q NP_000290.2 646 SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQG 719 (747) Q Consensus 646 s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~~~ 719 (747) ........++.++..++.+|.+|+...+.....+.+.++++.|..++....++.++..++.+|.+++.+.+.+. T Consensus 382 ~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~ll~~~~~~~v~~~a~~~L~~l~~~~~~~~ 455 (457) T 1XM9_A 382 SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQG 455 (457) T ss_dssp SCCSCSTTHHHHHHHHHHHHHHHHTTCTHHHHHHCCHHHHHHHHHHHHCTTCHHHHHHHHHHHHTTSSSTTCSS T ss_pred cCCCCCCCCHHHHHHHHHHHHHHHhcCHHHHHHHHhccHHHHHHHHHhCCCCHHHHHHHHHHHHHHhhcHhHhc Confidence 52000000567888999999999865566666777778889999988862278899999999999998877654 No 2 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=99.41 E-value=1.1e-17 Score=185.51 Aligned_cols=438 Identities=32% Similarity=0.540 Sum_probs=299.3 Template_Neff=11.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~ 323 (747) ..++.++.++...++.++..++.+|.+++.........+...++++.|+.++.+.+..++..++.+|.+++.. ...... T Consensus 48 ~~l~~li~~L~~~~~~v~~~a~~~L~~L~~~~~~~~~~~~~~g~i~~Lv~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 127 (584) T 3L6X_A 48 PELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKI 127 (584) T ss_dssp CCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHGGGCSSHHHHHHHHHHHHHHTSSSCHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCCHHHHH Confidence 4566677777777788899999999998854444444455567888888888887788999999999999864 333444 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMS--REVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~--~~~~~~~ 401 (747) .+...+.++.++.++....+..++..++.+|.+++........++..++..|+.++..+.++|........ ....+++ T Consensus 128 ~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~L~~~~~~~~~l~~~~l~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 207 (584) T 3L6X_A 128 AIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWES 207 (584) T ss_dssp HHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHTTSGGGHHHHHHHTHHHCCCCCCHHHHCCC----------CCCCHH T ss_pred HHHcCChHHHHHHHHHHcCCHHHHHHHHHHHHHHhcCHHHHHHHHHHHHHHHHHhccccCCCCCCCCCcCCCCcccChHH Confidence 44555778888888863346678889999999998765544444445778888888888877754332211 1223455 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD-AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) +..++.++|+. ++..+ ..++.++...|+++.|+..++.++....-+.+.+++|.++|. T Consensus 208 v~~~a~~~L~~---------------------l~~~~~~~~~~l~~~~g~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~ 266 (584) T 3L6X_A 208 VLTNTAGCLRN---------------------VSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLR 266 (584) T ss_dssp HHHHHHHHHHH---------------------HTSSCHHHHHHHHHSTTHHHHHHHHHHHHHHTTCCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHH---------------------HhcCCHHHHHHHHhCCCHHHHHHHHHHHHhcCCCCChHHHHHHHHHHH Confidence 66666665543 22222 245556666789999999888765544557788999999999 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ||++..+.++|...+..+.... ..+ +-...+......+.+.++++.|+.++.... T Consensus 267 ~L~~~~~~~~~~~~~~~~~~~~-----------~~~--------------~~~~~~~~~~~~l~~~~~~~~l~~ll~~~~ 321 (584) T 3L6X_A 267 NLSYQVHREIPQAERYQEAAPN-----------VAN--------------NTGTSPARGYELLFQPEVVRIYISLLKESK 321 (584) T ss_dssp HHHTTHHHHSTTCCC---------------------------------------CCCCGGGGGGSHHHHHHHHHHHHHCC T ss_pred HHHhhhhccChhHHHHHHhcCc-----------CCC--------------CCCCCChhhhhHhhChhHHHHHHHHHHcCC Confidence 9999998888765554432110 000 111222233344567889999999998423 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEV 640 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~L 640 (747) ++.++..++.+|.+++......... ....+.+.++++.|+.++.+.++.++..++++|.+|+........+..++++.| T Consensus 322 ~~~~~~~a~~~L~~L~~~~~~~~~~-~~~~~~~~~~l~~L~~ll~~~~~~v~~~a~~~L~~L~~~~~~~~~l~~~~l~~L 400 (584) T 3L6X_A 322 TPAILEASAGAIQNLCAGRWTYGRY-IRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNL 400 (584) T ss_dssp CHHHHHHHHHHHHHHHSSCSHHHHH-HHHHHTSHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHhCCCccCCHH-HHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcChHHHHHHHcchHHHH Confidence 7788899999999998742100000 233445678899999999988889999999999999877444333334677888 Q NP_000290.2 641 TRLLTSHTGNT--SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS-ASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~--~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~~~~ 717 (747) +.++....... ..+..++..++.+|.+++...+.....+.+.++++.|+.++... .+..++..|+.+|.+++...+. T Consensus 401 ~~~L~~~~~~~~~~~~~~~~~~~l~~L~~l~~~~~~~~~~l~~~~~l~~L~~ll~~~~~~~~v~~~a~~~L~~l~~~~~~ 480 (584) T 3L6X_A 401 VKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKEL 480 (584) T ss_dssp HHTSSSSSCSGGGTCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHTCSSSCHHHHHHHHHHHHHHHTSHHH T ss_pred HHcCCCCCCCCCcCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHHH Confidence 88776521000 00344577889999998876666777777888899999988653 1478899999999999999999 Q NP_000290.2 718 QGVLRQQGFDRN 729 (747) Q Consensus 718 ~~~~~~~~~~~~ 729 (747) ...+.+.|+-.. T Consensus 481 ~~~l~~~g~~~~ 492 (584) T 3L6X_A 481 RKPLEKEGWKKS 492 (584) T ss_dssp HHHHHTTTCCGG T ss_pred HHHHHHcCCchh Confidence 999998888766 No 3 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=98.56 E-value=1.1e-11 Score=126.19 Aligned_cols=369 Identities=14% Similarity=0.172 Sum_probs=230.1 Template_Neff=13.100 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~ 320 (747) ....++.+...+.+.++.++..++.++..+....... ...+...++++.++..+. ..++.++..++.++..++..... T Consensus 11 ~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 90 (466) T 5D5K_C 11 VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSE 90 (466) T ss_dssp CSCCHHHHHHHHTSSCHHHHHHHHHHHHHHHTCSSCCCHHHHHHTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHH T ss_pred cCcCHHHHHHHHccCCHHHHHHHHHHHHHHHhcCCCCCHHHHHHcCcHHHHHHHhhCCCChHHHHHHHHHHHHHcCCChH Confidence 4456667777777778888999999998887643221 122333456777777776 34567888899999888764443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++..+. .+.. T Consensus 91 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~-----------~~~~ 158 (466) T 5D5K_C 91 QTKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPD-----------LSTL 158 (466) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHTTCSSC-----------GGGS T ss_pred HHHHHhccchHHHHHHHhc-CCCCcHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCC-----------cccc Confidence 3333444457777888876 56778888999999998875432 222333 67777777776421 1112 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-. .............+++..+...++. -+..-...+... T Consensus 159 ~~~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 211 (466) T 5D5K_C 159 ACGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWA 211 (466) T ss_dssp CHHHHHHHHHHHHHHS---------------------CCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHH---------------------cCCCCCCChHHHHHHHHHHHHHHcC------CCHHHHHHHHHH Confidence 3334444433332211 1011111111123444444443321 112222223333 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 212 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 240 (466) T 5D5K_C 212 ISYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG- 240 (466) T ss_dssp HHHHTSSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT- T ss_pred HHHHhcCC--------------------------------------------------chHHHHHHHCChHHHHHHHhc- Confidence 33332110 001111234567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++ T Consensus 241 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~ 315 (466) T 5D5K_C 241 ATELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 315 (466) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTC T ss_pred CCCchHHHHHHHHHHHHhcCCHH-----HHHHHHccChhHhHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCH Confidence 46778888999999999875332 233334567888999999888889999999999999876 322 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+..++.+ .++.++..++.+|.+++.. .......+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 316 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~ 386 (466) T 5D5K_C 316 VPFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 386 (466) T ss_dssp HHHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHH Confidence 8888888876 3678889999999999874 233344455556788888888866 78899999999999987 No 4 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=98.55 E-value=1.3e-11 Score=128.97 Aligned_cols=381 Identities=18% Similarity=0.200 Sum_probs=233.7 Template_Neff=12.000 Q NP_000290.2 238 EDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQN------------VQQ 305 (747) Q Consensus 238 ~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~e------------Vr~ 305 (747) .+..+...+++.++.++...+... ++.+|..++.. ......+...+.++.+..++...+.. ++. T Consensus 25 ~~~~~~~~~i~~l~~~l~~~~~~~---a~~~L~~l~~~-~~~~~~~~~~g~i~~L~~ll~~~~~~~~~~~~~~~~~~v~~ 100 (458) T 3NMZ_A 25 SHLGTKVEMVYSLLSMLGTHDKDD---MSRTLLAMSSS-QDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARA 100 (458) T ss_pred HHhHhccchHHHHHHHhCCCCHHH---HHHHHHHHhCC-chHHHHHHHcCcHHHHHHHhcCCChhhcCCCCcccCHHHHH Confidence 344445556677777776554443 77778777643 23333444556778888888765555 888 Q NP_000290.2 306 AAAGALRNLVFRST---TNKLETRRQNGIREAVSLLR--------------------RTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 306 ~AL~aLs~La~~~~---~~~~~ll~~~IL~~Ll~lL~--------------------ss~d~eVr~~AL~aLsnLas~~~ 362 (747) .++.+|.+++...+ .....+...+.++.+...+. ...+..++..++.++.+++.... T Consensus 101 ~a~~~L~~l~~~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~L~~l~~~~~ 180 (458) T 3NMZ_A 101 RASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEE 180 (458) T ss_pred HHHHHHHHHHcCCCCCHHHHHHHHHCCcHHHHHHHHHhhhhcccchhhHHHHHHhcCCCChHHHHHHHHHHHHHHcCChH Confidence 99999999885432 22222222334444444421 01234455667778887776554 Q NP_000290.2 363 LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAG 440 (747) Q Consensus 363 ~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~ 440 (747) ....+.. ++++.|+.++....... .... ...++++...+..+|.. +... +.. T Consensus 181 ~~~~~~~~~~~~~l~~~l~~~~~~~----~~~~-~~~~~~~~~~a~~~L~~---------------------l~~~~~~~ 234 (458) T 3NMZ_A 181 HRHAMNELGGLQAIAELLQVDCEMY----GLTN-DHYSITLRRYAGMALTN---------------------LTFGDVAN 234 (458) T ss_pred HHHHHHHCChHHHHHHHHhccccCC----CCCC-CCCCHHHHHHHHHHHHH---------------------HHcCCHHH Confidence 4444444 77888888877532211 1110 11244554444444432 1111 111 Q NP_000290.2 441 RQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDK 520 (747) Q Consensus 441 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 520 (747) ++.+....|+++.|...++. .+..-.+.+..+|.|++..-+. T Consensus 235 ~~~~~~~~~~i~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~-------------------------------- 276 (458) T 3NMZ_A 235 KATLCSMKGCMRALVAQLKS------ESEDLQQVIASVLRNLSWRADV-------------------------------- 276 (458) T ss_pred HHHHHHhCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHCCCCh-------------------------------- Confidence 22233445667777666542 2334445555566665431100 Q NP_000290.2 521 MMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQ 599 (747) Q Consensus 521 ~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~ 599 (747) .....+.+.++++.|+.++....+..++..++++|.+++...+. ....+.. .++++. T Consensus 277 -----------------~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~ 334 (458) T 3NMZ_A 277 -----------------NSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAF 334 (458) T ss_pred -----------------hHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCch-----hHHHHHHhcChHHH Confidence 01122356678888888887325667888999999999874332 2233344 778888 Q NP_000290.2 600 IARLLQS----GNSDVVRSGASLLSNMSR---H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 600 Ll~LL~s----~d~eVr~~AL~aLsnLa~---~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) |+.++.. .+..++..++.+|.+++. . ... ..+...++++.|+.++.. .++.++..++++|.+++. T Consensus 335 l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~ 408 (458) T 3NMZ_A 335 LVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSA 408 (458) T ss_pred HHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhCC------CCHHHHHHHHHHHHHHHC Confidence 8888872 346778889999988863 2 222 233456788888888876 367889999999999998 Q NP_000290.2 671 SQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 671 ~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ..+.....+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 409 ~~~~~~~~l~~~~~~~~L~~ll~~~-~~~v~~~a~~~L~~l~~~~ 452 (458) T 3NMZ_A 409 RNPKDQEALWDMGAVSMLKNLIHSK-HKMIAMGSAAALRNLMANR 452 (458) T ss_pred CCHHHHHHHHHCCcHHHHHHHHhCC-CHHHHHHHHHHHHHHHcCC Confidence 5566677777778899999988876 6778999999999998654 No 5 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=98.54 E-value=1.3e-11 Score=125.71 Aligned_cols=369 Identities=14% Similarity=0.172 Sum_probs=229.2 Template_Neff=13.100 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~ 320 (747) ....++.+...+.+.++.++..++.++..+....... ...+...++++.++..+. ..++.++..++.++..++..... T Consensus 11 ~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 90 (466) T 4UAF_B 11 VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSE 90 (466) T ss_pred cCcCHHHHHHHHccCCHHHHHHHHHHHHHHHhcCCCCCHHHHHHcCcHHHHHHHhhCCCChHHHHHHHHHHHHHhcCChH Confidence 4456667777777778888999999998887643221 122333456777777776 34567888899999888764443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++..+. .+.. T Consensus 91 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~-----------~~~~ 158 (466) T 4UAF_B 91 QTKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPD-----------LSTL 158 (466) T ss_pred HHHHHHccChHHHHHHHhc-CCCCCHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCC-----------cccc Confidence 3333444457777888876 56778888999999998875432 222233 67777777775421 1112 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-. .............+++..+...+.. -+..-...+... T Consensus 159 ~~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 211 (466) T 4UAF_B 159 ACGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWA 211 (466) T ss_pred cHHHHHHHHHHHHHHH---------------------cCCCCCCChhHHHHHHHHHHHHHcC------CCHHHHHHHHHH Confidence 3334333333332211 0001111111113344444433321 111222222333 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 212 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 240 (466) T 4UAF_B 212 ISYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG- 240 (466) T ss_pred HHHHhcCC--------------------------------------------------cHHHHHHHHCChHHHHHHHhc- Confidence 33332110 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++ T Consensus 241 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~ 315 (466) T 4UAF_B 241 ATELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 315 (466) T ss_pred CCChhHHHHHHHHHHHHhcCCHH-----HHHHHhccCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCH Confidence 46778888999999999875332 233334567888899999888889999999999999876 322 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 316 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~ 386 (466) T 4UAF_B 316 VPFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 386 (466) T ss_pred HHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHH Confidence 8888888876 3678889999999999874 233344455556788888888876 78899999999999987 No 6 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=98.52 E-value=1.7e-11 Score=122.96 Aligned_cols=360 Identities=16% Similarity=0.184 Sum_probs=217.1 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 49 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 128 (426) T 4U5L_A 49 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 128 (426) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhccCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcCcHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 445678888899998887654433334444567778888888778888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 129 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 191 (426) T 4U5L_A 129 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 191 (426) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHTCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHhh-CCCCchhhHHHHHHHHHHHHHHHcCCCCCCCccHHHHHHHHHHHHHhC---------------- Confidence 334456677777765 32222 67778888888776433222221 2555666665542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-.... + .....+. -.+++..|...+.. .+..-...+.. T Consensus 192 ~~~~~~~~a~~~l~~l~~~~------~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~ 244 (426) T 4U5L_A 192 NDPEVLADSCWAISYLTDGP------N--------------ERIEMVV-KKGVVPQLVKLLGA------TELPIVTPALR 244 (426) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHHH-TTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhhCC------c--------------HHHHHHh-hcChHHHHHHHhcC------CCccHHHHHHH Confidence 13444444444443211100 0 0000000 12233333333221 11122222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++...- ......+.+.++++.+..++. T Consensus 245 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 274 (426) T 4U5L_A 245 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 274 (426) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHhccchHHHHHHHhc Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 275 -~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 348 (426) T 4U5L_A 275 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 348 (426) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHT T ss_pred -CCChHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899998888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.++ T Consensus 349 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~ll~~~-~~~v~~~a~~~l 421 (426) T 4U5L_A 349 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 421 (426) T ss_dssp TCHHHHHHGGGS------CCHHHHHHHHHHHHHHHHHHHTTTCHHHHHHHHHHTTHHHHHHGGGGSS-CHHHHHHHHHHH T ss_pred CcHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHhcCchHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 678888888876 3678899999999999763 123333444556788888888776 788898888888 Q NP_000290.2 709 SDMW 712 (747) Q Consensus 709 snL~ 712 (747) .++. T Consensus 422 ~~~~ 425 (426) T 4U5L_A 422 EKYF 425 (426) T ss_dssp HHHC T ss_pred HHHc Confidence 7764 No 7 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=98.48 E-value=2.5e-11 Score=127.02 Aligned_cols=136 Identities=24% Similarity=0.253 Sum_probs=93.8 Template_Neff=12.500 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.+|..++.........+...++++.+...+.+.++.++..++.++..++........ T Consensus 172 ~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~ 251 (510) T 6SA7_B 172 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQ 251 (510) T ss_dssp HHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHTCHHHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHH T ss_pred HHHHHHHHHHhcCCChHHHHHHHHHHHHHhcCChHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 45666777777777788889999999998765544444444556788888888887888999999999998765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .+...++++.+...+. +.++.++..++.++..++..... ...+.. ++++.|+.++. T Consensus 252 ~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 309 (510) T 6SA7_B 252 AVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 309 (510) T ss_dssp HHHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHHcCcHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCChHHHHHHHHcChHHHHHHHhc Confidence 3444567777777775 55677888888888888754322 222222 56666666664 No 8 >4RV1_D Engineered Protein OR497; STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE; 2.573A {SYNTHETIC CONSTRUCT} Probab=98.47 E-value=2.7e-11 Score=120.80 Aligned_cols=362 Identities=20% Similarity=0.254 Sum_probs=220.3 Template_Neff=13.300 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++........... T Consensus 4 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 83 (420) T 4RV1_D 4 VEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIV 83 (420) T ss_dssp HHHHHHHHHCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHTTSCSCSSSHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHHHCCHHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHH Confidence 44556666677788888999999888765433333333446677777888777788899999999888765433323333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ..++++.+...+. +.++.++..++.++..+..... ....+.. ++++.+..++.. .++++.. T Consensus 84 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~~ 146 (420) T 4RV1_D 84 DAGGVEVLVKLLT-STDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTS----------------TDSEVQK 146 (420) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTC----------------SCHHHHH T ss_pred HcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCChHHHHHHHHcCHHHHHHHHHhC----------------CCHHHHH Confidence 3456677777776 5567788889999988876432 2222222 566666666542 1344444 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.... + .....+. ..+++..+...++. .+..-...+..+|.++.. T Consensus 147 ~a~~~l~~l~~~~------~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 199 (420) T 4RV1_D 147 EAARALANIASGP------D--------------EAIKAIV-DAGGVEVLVKLLTS------TDSEVQKEAARALANIAS 199 (420) T ss_dssp HHHHHHHHHHTSC------H--------------HHHHHHH-HTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHhcCC------H--------------HHHHHHH-HCCHHHHHHHHhcC------CCHHHHHHHHHHHHHHhC Confidence 4443332211000 0 0000000 01333333333221 111111222222222211 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) .. ......+.+.++++.+...+. +.++.+ T Consensus 200 ~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~~ 228 (420) T 4RV1_D 200 GP--------------------------------------------------TSAIKAIVDAGGVEVLVKLLT-STDSEV 228 (420) T ss_dssp SC--------------------------------------------------HHHHHHHHTTTHHHHHHHHTT-CSCHHH T ss_pred CC--------------------------------------------------HHHHHHHHHCCHHHHHHHHhh-CCCHHH Confidence 00 000111234456777888887 467788 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPEVTR 642 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~Ll~ 642 (747) +..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.... . ..+...++++.+.. T Consensus 229 ~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~ 303 (420) T 4RV1_D 229 QKEAARALANIASGPDE-----AIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVK 303 (420) T ss_dssp HHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHH T ss_pred HHHHHHHHHHHhCCCHH-----HHHHHhhccHHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHH Confidence 88999999998864332 12233456788888888888888899999999999987632 2 23344467777888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+ .++.++..++.+|.+++...+.....+...+.++.+..++.+. ++.++..++.+|.+++... T Consensus 304 ~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~ 369 (420) T 4RV1_D 304 LLTS------TDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTST-DSEVQKEAARALANIASGP 369 (420) T ss_dssp HTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHHTSC T ss_pred HccC------CCHHHHHHHHHHHHHHHcChHHHHHHHHHCCHHHHHHHHhCCC-CHHHHHHHHHHHHHHHcCC Confidence 7776 3678899999999999876444444455556788888888766 7889999999999998764 No 9 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=98.47 E-value=2.8e-11 Score=117.85 Aligned_cols=167 Identities=20% Similarity=0.267 Sum_probs=122.0 Template_Neff=13.100 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 170 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~ 243 (344) T 6S9O_F 170 DAGALPALVQLLS-SPNEQILQLALWALSNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIAS 243 (344) T ss_dssp HTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred hCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHhcChHHHHHHHccCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46777888899999998864332 12333445788888888888888899999999999986 Q NP_000290.2 625 H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) . ... ......++++.+..++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++. T Consensus 244 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 316 (344) T 6S9O_F 244 GGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSHE-NEKIQK 316 (344) T ss_dssp SCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHH T ss_pred CcHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhhCC-CHHHHH Confidence 5 222 233445677778887766 3678889999999999876555555555556788888888766 788999 Q NP_000290.2 703 AARLLLSDMWSSKELQGVLRQQ 724 (747) Q Consensus 703 aAL~aLsnL~~~~~~~~~~~~~ 724 (747) .++.+|.+++...+.....+.. T Consensus 317 ~a~~~l~~l~~~~~~~~~~~~~ 338 (344) T 6S9O_F 317 EAQEALEKLQSHGSGGSGKRKR 338 (344) T ss_dssp HHHHHHHHHHHCSCCCCCCCBC T ss_pred HHHHHHHHHHhcccCCCchhcc Confidence 9999999998776654444333 No 10 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=98.46 E-value=3e-11 Score=116.21 Aligned_cols=318 Identities=20% Similarity=0.263 Sum_probs=178.1 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..+..........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 84 (328) T 5MFD_C 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 84 (328) T ss_dssp CHHHHHHHHHSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHH Confidence 45556666666777888889999988876544333334445677788888877778888889998888875433322223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++.. .++++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~ 147 (328) T 5MFD_C 85 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSS----------------PNEQIL 147 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC----------------SCHHHH T ss_pred hhcCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcC----------------CCHHHH Confidence 33345666666665 4455666777777777665321 1111111 334444433321 011111 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) .. ++..|.++. T Consensus 148 ~~---------------------------------------------------------------------a~~~l~~l~ 158 (328) T 5MFD_C 148 QE---------------------------------------------------------------------ALWTLGNIA 158 (328) T ss_dssp HH---------------------------------------------------------------------HHHHHHHHT T ss_pred HH---------------------------------------------------------------------HHHHHHHHH Confidence 11 111222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ .....+.+.++++.++.++. +.++. T Consensus 159 ~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~~~~ 187 (328) T 5MFD_C 159 SGGN--------------------------------------------------EQIQAVIDAGALPALVQLLS-SPNEQ 187 (328) T ss_dssp TSCH--------------------------------------------------HHHHHHHHTTHHHHHHHGGG-CSCHH T ss_pred cCCH--------------------------------------------------HHHHHHHHCCcHHHHHHHhc-CCCHH Confidence 0000 00000122345556666665 35556 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.++.+++.. +.. ......++++.+. T Consensus 188 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 262 (328) T 5MFD_C 188 ILQEALWTLGNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALV 262 (328) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHH Confidence 666777777777654221 122223445667777777666667777777777777654 222 2223345666666 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) .++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++..++.+|.+++ T Consensus 263 ~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~ 326 (328) T 5MFD_C 263 QLLSS------PNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQSHE-NEKIQKEAQEALEKLQ 326 (328) T ss_dssp HGGGC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHHHHH T ss_pred HHhcC------CCHHHHHHHHHHHHHHhCCcHHHHHHHHHCCHHHHHHHHhhCC-CHHHHHHHHHHHHHHh Confidence 66655 2566777777777777765444444444445667777777655 6677777777777665 No 11 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=98.45 E-value=3.5e-11 Score=125.01 Aligned_cols=368 Identities=14% Similarity=0.178 Sum_probs=227.8 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAK-QQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~-~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~ 321 (747) ..+++.+...+.+.++.++..++.++..+........ ..+...++++.+...+...+ +.++..++.++..++...... T Consensus 56 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~ 135 (509) T 4MZ6_E 56 NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQ 135 (509) T ss_dssp TCCHHHHHHHHTTCCHHHHHHHHHHHHHHHTCSSCCCHHHHHHTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHH T ss_pred hhhHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHH Confidence 4456667777777788889999999988876433211 22333456777777776543 678888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|+.++..... +..+ T Consensus 136 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~ 203 (509) T 4MZ6_E 136 TKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLA 203 (509) T ss_dssp HHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTCSSCG-----------GGSC T ss_pred HHHHHhcChHHHHHHHhc-CCChhHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhCCCh-----------hhhh Confidence 333444467777888886 56778889999999998875432 222223 677777777764211 1122 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++...+..+|..-. .............+++..+...+.. -+......+...| T Consensus 204 ~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 256 (509) T 4MZ6_E 204 CGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAI 256 (509) T ss_dssp HHHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh---------------------cCCCCCCCHHHHHHHHHHHHHHHhC------CCHHHHHHHHHHH Confidence 333333333332211 0000011111112334444333321 1111222222223 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.|+.++. + T Consensus 257 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 285 (509) T 4MZ6_E 257 SYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG-A 285 (509) T ss_dssp HHHTSSS--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT-C T ss_pred HHHhcCC--------------------------------------------------hHHHHHHhhCChHHHHHHHhc-C Confidence 3222100 001112244567888888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...+++ T Consensus 286 ~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 360 (509) T 4MZ6_E 286 TELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLV 360 (509) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHH T ss_pred CCcchHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHH Confidence 6778888999999999875332 233334567888899999888889999999999999876 322 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.++.++.+ .++.++..++.+|.+++.. .+.....+.+.++++.|..++.+. ++.++..++.+|.+++. T Consensus 361 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 430 (509) T 4MZ6_E 361 PFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCCHHHHHHHHhCC-CHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999874 234444555556788888888876 78899999999999987 No 12 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=98.45 E-value=3.5e-11 Score=125.01 Aligned_cols=368 Identities=14% Similarity=0.178 Sum_probs=227.8 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAK-QQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~-~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~ 321 (747) ..+++.+...+.+.++.++..++.++..+........ ..+...++++.+...+...+ +.++..++.++..++...... T Consensus 56 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~ 135 (509) T 5UMZ_B 56 NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQ 135 (509) T ss_dssp SCCHHHHHHHHTSSCHHHHHHHHHHHHHHHTSSSCCCHHHHHHTTCHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHH T ss_pred hhhHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHH Confidence 4456667777777788889999999988876433211 22333456777777776543 678888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|+.++..... +..+ T Consensus 136 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~ 203 (509) T 5UMZ_B 136 TKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLA 203 (509) T ss_dssp HHHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHTCHHHHHHHHHTTCHHHHHHHTCSSCG-----------GGSC T ss_pred HHHHHhcChHHHHHHHhc-CCChhHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhCCCh-----------hhhh Confidence 333444467777888886 56778889999999998875432 222223 677777777764211 1122 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++...+..+|..-. .............+++..+...+.. -+......+...| T Consensus 204 ~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 256 (509) T 5UMZ_B 204 CGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAI 256 (509) T ss_dssp HHHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh---------------------cCCCCCCCHHHHHHHHHHHHHHHhC------CCHHHHHHHHHHH Confidence 333333333332211 0000011111112334444333321 1111222222223 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.|+.++. + T Consensus 257 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 285 (509) T 5UMZ_B 257 SYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG-A 285 (509) T ss_dssp HHHTSSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT-C T ss_pred HHHhcCC--------------------------------------------------hHHHHHHhhCChHHHHHHHhc-C Confidence 3222100 001112244567888888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...+++ T Consensus 286 ~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 360 (509) T 5UMZ_B 286 TELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLV 360 (509) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHH T ss_pred CCcchHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHH Confidence 6778888999999999875332 233334567888899999888889999999999999876 322 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.++.++.+ .++.++..++.+|.+++.. .+.....+.+.++++.|..++.+. ++.++..++.+|.+++. T Consensus 361 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 430 (509) T 5UMZ_B 361 PFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCCHHHHHHHHhCC-CHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999874 234444555556788888888876 78899999999999987 No 13 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=98.45 E-value=3.6e-11 Score=122.13 Aligned_cols=367 Identities=14% Similarity=0.163 Sum_probs=226.8 Template_Neff=13.000 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA--KQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~--~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~ 320 (747) +.+++.+...+.+.++.++..++.+|..+....... ...+...++++.+...+.. .++.++..++.++..++..... T Consensus 19 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 98 (450) T 2JDQ_A 19 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL 98 (450) T ss_dssp ---CHHHHHHHHSSCHHHHHHHHHHHHHHHHSSSSCCHHHHHTSTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHSSCHH T ss_pred CcccHHHHHHHhcCCHHHHHHHHHHHHHHHccCCCCCHhHHhcCcchHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCcH Confidence 445567777788788889999999999887532211 1222224667777777765 5677888899999888765443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.++.++... . T Consensus 99 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~ 162 (450) T 2JDQ_A 99 QTRIVIQAGAVPIFIELLS-SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ---------------N 162 (450) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC---------------C T ss_pred HHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHHHHHHHCCCHHHHHHHHhhc---------------c Confidence 3333333467777888876 5567888899999998887543 2223333 6777777776431 1 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-.. ............+++..+...+.. -+..-...+... T Consensus 163 ~~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 215 (450) T 2JDQ_A 163 RLTMTRNAVWALSNLCR---------------------GKSPPPEFAKVSPCLNVLSWLLFV------SDTDVLADACWA 215 (450) T ss_dssp CHHHHHHHHHHHHHHHC---------------------CSSSCCCGGGTGGGHHHHHHHTTC------CCHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHhc---------------------CCCCCchhhhhhhHHHHHHHHhcC------CCHHHHHHHHHH Confidence 23443344333322110 000111111222333333332221 111122222223 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 216 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 244 (450) T 2JDQ_A 216 LSYLSDGP--------------------------------------------------NDKIQAVIDAGVCRRLVELLM- 244 (450) T ss_dssp HHHHTSSS--------------------------------------------------HHHHHHHHHTTTHHHHHHHTT- T ss_pred HHHHhcCC--------------------------------------------------HHHHHHHHHCCHHHHHHHHHc- Confidence 33222110 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+.+.++++.+..++.+.++.++..++.+|.+++... .. ......++ T Consensus 245 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 319 (450) T 2JDQ_A 245 HNDYKVVSPALRAVGNIVTGDDI-----QTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANI 319 (450) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTH T ss_pred CCCHHHHHHHHHHHHHHhhCChH-----HHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCH Confidence 46778888999999999875332 2233345578888999998888889999999999998762 22 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ-PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++... T Consensus 320 ~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 392 (450) T 2JDQ_A 320 FPALISILQT------AEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVM-DSKIVQVALNGLENILRLG 392 (450) T ss_dssp HHHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc------CCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHHHh Confidence 8888888876 36788899999999998752 34445555556788888888876 7889999999999998765 Q NP_000290.2 716 E 716 (747) Q Consensus 716 ~ 716 (747) + T Consensus 393 ~ 393 (450) T 2JDQ_A 393 E 393 (450) T ss_dssp H T ss_pred H Confidence 4 No 14 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=98.45 E-value=3.6e-11 Score=124.32 Aligned_cols=364 Identities=17% Similarity=0.189 Sum_probs=218.6 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 76 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 155 (485) T 4E4V_A 76 LIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 155 (485) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhcCChHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665443 678888889988887654433334444567778888888777888999999999888654432333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNA-----EIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~-----eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. .... .++..++.++..++.......... .++++.+..++.. T Consensus 156 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 218 (485) T 4E4V_A 156 VIKYGAVDPLLALLA-VPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHH---------------- 218 (485) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHTCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHHh-CCCcccchHHHHHHHHHHHHHHHhCCCCCCCHHHHhcHHHHHHHHhcC---------------- Confidence 333456666776665 2222 567778888888876443222222 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..+|..-.. .+......---.+++..|...+.. .+..-...+.. T Consensus 219 ~~~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~ 271 (485) T 4E4V_A 219 DDPEVLADTCWAISYLTD---------------------GPNERIGMVVKTGVVPQLVKLLGA------SELPIVTPALR 271 (485) T ss_dssp CCHHHHHHHHHHHHHHTS---------------------SCHHHHHHHHTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhc---------------------CChHHhhHHhhCChHHHHHHHhcC------CChHHHHHHHH Confidence 134444444444432110 000000000012233333333221 11222223333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++...- ......+.+.++++.|+.++. T Consensus 272 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 301 (485) T 4E4V_A 272 AIGNIVTGT--------------------------------------------------DEQTQVVIDAGALAVFPSLLT 301 (485) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHHT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhc Confidence 333332100 001112234567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 302 -~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 375 (485) T 4E4V_A 302 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHC 375 (485) T ss_dssp -CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHcCCCHH-----HHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899999888888999999999999875 2 12 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ------PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s------~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++... +.....+.+.++++.|..++.+. ++.++..++.+| T Consensus 376 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 448 (485) T 4E4V_A 376 GIIEPLMNLLTA------KDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE-NESVYRASLSLI 448 (485) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHTTHHHHHHTTCCTT-SHHHHHHHHHHH T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCChhHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 677888888776 36788999999999998731 22333344456788888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 449 ~~l~~~~~ 456 (485) T 4E4V_A 449 EKYFSVEE 456 (485) T ss_dssp HHHCC--- T ss_pred HHHcCccc Confidence 99986543 No 15 >4B18_A IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE; TRANSPORT PROTEIN - PEPTIDE COMPLEX; 2.52A {HOMO SAPIENS} Probab=98.44 E-value=4e-11 Score=121.64 Aligned_cols=368 Identities=14% Similarity=0.162 Sum_probs=227.4 Template_Neff=13.000 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES--AKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~--~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~ 320 (747) +.+++.+...+.+.++.++..++.+|..+...... ....+...++++.+...+.. .++.++..++.++..++..... T Consensus 16 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 95 (447) T 4B18_A 16 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL 95 (447) T ss_dssp CSSCHHHHHHHTSSCHHHHHHHHHHHHHHHHCSSCCCHHHHHTSTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTSSCHH T ss_pred CCCcHHHHHHHhcCCHHHHHHHHHHHHHHhCCCCCCCHhHHhcCccHHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCcH Confidence 44556677777777888899999999888753221 11222224667777777765 5677888899999888765433 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... . T Consensus 96 ~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~ 159 (447) T 4B18_A 96 QTRIVIQAGAVPIFIELLS-SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ---------------N 159 (447) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGCT---------------T T ss_pred HHHHHHHcChHHHHHHHhh-CCCHHHHHHHHHHHHHHHccChhHHHHHHHCCcHHHHHHHhhcC---------------C Confidence 3223333467777888776 5567888899999998887543 2223333 6677777766431 1 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..+|..-. .............+++..+...++. -+......+... T Consensus 160 ~~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 212 (447) T 4B18_A 160 RLTMTRNAVWALSNLC---------------------RGKSPPPEFAKVSPCLNVLSWLLFV------SDTDVLADACWA 212 (447) T ss_dssp CHHHHHHHHHHHHHHH---------------------CCSSSCCCHHHHGGGHHHHHHHTTS------CCHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHh---------------------cCCCCCCcccccccHHHHHHHHhhC------CCHHHHHHHHHH Confidence 2344333333332211 0000111111122333333322211 111112222222 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 213 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 241 (447) T 4B18_A 213 LSYLSDGP--------------------------------------------------NDKIQAVIDAGVCRRLVELLM- 241 (447) T ss_dssp HHHHTSSS--------------------------------------------------HHHHHHHHHTTCHHHHHHHTT- T ss_pred HHHHhcCC--------------------------------------------------HHHHHHHHHCCHHHHHHHHHc- Confidence 32222100 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+.+.++++.|..++.+.++.++..++.+|.+++... .. ......++ T Consensus 242 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 316 (447) T 4B18_A 242 HNDYKVVSPALRAVGNIVTGDDI-----QTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANI 316 (447) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTH T ss_pred CCCHHHHHHHHHHHHHHhcCChH-----HHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCh Confidence 46778888999999999875332 2233345578888999998888889999999999998762 22 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++... T Consensus 317 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 389 (447) T 4B18_A 317 FPALISILQT------AEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVM-DSKIVQVALNGLENILRLG 389 (447) T ss_dssp HHHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc------CCHHHHHHHHHHHHHHhccCCHHHHHHHHHCCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHHHh Confidence 8888888876 3678899999999999875 234445555556788888888876 7889999999999998765 Q NP_000290.2 716 EL 717 (747) Q Consensus 716 ~~ 717 (747) +. T Consensus 390 ~~ 391 (447) T 4B18_A 390 EQ 391 (447) T ss_dssp HH T ss_pred HH Confidence 43 No 16 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.43 E-value=4.3e-11 Score=119.82 Aligned_cols=363 Identities=16% Similarity=0.214 Sum_probs=223.0 Template_Neff=13.200 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +.+...+.+.++.++..++..+..++..... ........++++.+...+...+ +.++..++.++..++.........+ T Consensus 4 ~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 83 (423) T 4XZR_B 4 PQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVV 83 (423) T ss_dssp SSSSTTTSSSCHHHHHHHHHHHHHHHSCSSSCCHHHHHTTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hhHhhhcChHhHHHHHHHHHHHHHHHcCCCCCchHHHHhCCcHHHHHHHhhCCCCHHHHHHHHHHHHHHhCCCchhhhHH Confidence 4455566667777888888888877654321 1222333466777777776543 6778889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. +.++.++..++.++..++... .....+.. ++++.|..++... ++++. T Consensus 84 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 146 (423) T 4XZR_B 84 VDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSLI 146 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC----------------CHHHH T ss_pred cccchHHHHHHHHh-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHHH Confidence 33467777777776 567788899999999988753 22233333 6677777766521 34444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. .........-..+.++.|...++. .+......+...|.++. T Consensus 147 ~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~ 199 (423) T 4XZR_B 147 RTATWTLSNLCR---------------------GKKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYLS 199 (423) T ss_dssp HHHHHHHHHHHC---------------------CCTTCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc---------------------CCCCCCChHHhccHHHHHHHHhhC------CCHHHHHHHHHHHHHHh Confidence 444444432111 000001111122334444333321 11112222222333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) .. +......+.+.++++.++.++. +.++. T Consensus 200 ~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~~ 228 (423) T 4XZR_B 200 DG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HESTL 228 (423) T ss_dssp SS--------------------------------------------------SHHHHHHHHHTTHHHHHHHHTT-CSCHH T ss_pred cC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCHH Confidence 11 0011122345567888888887 46778 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++... .. ..+...++++.+. T Consensus 229 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 303 (423) T 4XZR_B 229 VQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLV 303 (423) T ss_dssp HHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHH Confidence 888999999999865332 2223334578888888888888889999999999998762 22 3334556778888 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQP---QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) .++.+ .++.++..++.+|.+++.... .....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 304 ~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~~ 375 (423) T 4XZR_B 304 KLLEV------AEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHH------SCHHHHHHHHHHHHHHHHGGGTCHHHHHHHHHTTCHHHHHHHTTTS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHh------CCchHHHHHHHHHHHHHhCCCCCHHHHHHHHHCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 88866 367889999999999987532 2234445556788888888876 788899999999999876554 No 17 >5XZX_A Importin subunit alpha-3, Ran-binding protein; nuclear import, TRANSPORT PROTEIN; 3.0A {Homo sapiens} Probab=98.43 E-value=4.3e-11 Score=119.52 Aligned_cols=133 Identities=19% Similarity=0.169 Sum_probs=87.0 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++.+|..+...... ....+...++++.+...+. ..++.++..++.++..++......... T Consensus 4 ~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 83 (416) T 5XZX_A 4 LEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQA 83 (416) T ss_dssp HHHHHHHTTCSSHHHHHHHHHHHHHTTSSSSSCCHHHHHTTTCHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred HHHHHHHHhcCCHHHHHHHHHHHHHHHhCCCCCCHHHHHHcCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCChHHHHH Confidence 44566666677778888999999888764321 1122333456777777776 456778888899998887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+...+. +.++.++..++.++..++... .....+.. ++++.|..++. T Consensus 84 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (416) T 5XZX_A 84 VVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFIS 140 (416) T ss_dssp HHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHHTCHHHHTTSCS T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCccHHHHHHhcC Confidence 334457777777776 567788899999999988652 22222333 66677776664 No 18 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=98.42 E-value=4.4e-11 Score=123.86 Aligned_cols=378 Identities=19% Similarity=0.226 Sum_probs=227.0 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 180 (529) T 1JDH_A 101 GGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLI 180 (529) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCTTHHHHHHHHTHHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred CCHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcchHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666667788888999998887654333333334567777888887777888899999999888544433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++. T Consensus 181 ~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 244 (529) T 1JDH_A 181 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLV 244 (529) T ss_dssp HHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHTTTTSS----------------CHHHH T ss_pred HHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCccHHHHHHCCHHHHHHHHccCC----------------CHHHH Confidence 444457777777776333567888888888888875443333333 6667776666432 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. ........+ .+++..+...++. -+..-...+...|.++. T Consensus 245 ~~~~~~l~~l~---------------------~~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 294 (529) T 1JDH_A 245 QNCLWTLRNLS---------------------DAATKQEGM---EGLLGTLVQLLGS------DDINVVTCAAGILSNLT 294 (529) T ss_dssp HHHHHHHHHHH---------------------TTCTTCSCC---HHHHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHc---------------------chhhhHHHH---chHHHHHHHHhCC------CCHHHHHHHHHHHHHHh Confidence 33333332110 000000001 2334444333321 11111222223333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKD 562 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~ 562 (747) ... ......+.+.++++.++..+.. ..++ T Consensus 295 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 324 (529) T 1JDH_A 295 CNN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRE 324 (529) T ss_dssp TTC--------------------------------------------------HHHHHHHHHTTHHHHHHHHHHHHTTCH T ss_pred cCC--------------------------------------------------HHHHHHHHHcCHHHHHHHHHHhcCCCh Confidence 110 0001112345667777776641 2456 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++..... .......+...++++.+..++.+. ++.++..++.+|.+++..... ..+...++++.+ T Consensus 325 ~~~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l 402 (529) T 1JDH_A 325 DITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRL 402 (529) T ss_dssp HHHHHHHHHHHHHTSSSTT--HHHHHHHHHHTTCHHHHHHTTSTTCCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHH T ss_pred HhHHHHHHHHHHHhcCccc--HHHHHHHHHhcccHHHHHHHHCCCCCHHHHHHHHHHHHHHhcChhhhHHHHhcCHHHHH Confidence 7788899999998865331 000012222456788888888765 678899999999999876433 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNS--------------------EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 641 l~LL~s~s~~~~~d--------------------~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..++.... .+ +.++..++.+|.+++.. ......+...++++.++.++.+. ++.+ T Consensus 403 ~~~l~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~~ 476 (529) T 1JDH_A 403 VQLLVRAH----QDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD-VHNRIVIRGLNTIPLFVQLLYSP-IENI 476 (529) T ss_dssp HHHHHHHH----HHHC-----------CBTTBCHHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHGGGCS-CHHH T ss_pred HHHHHhcC----hhHHHHHhccCcchhHhccCCHHHHHHHHHHHHHHHhcC-ccchHHHHhcCcHHHHHHHhcCC-CHHH Confidence 88876520 01 67888999999999875 34444455556788888888876 7889 Q NP_000290.2 701 AEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 701 r~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) +..++.+|.+++...+....+...|+ T Consensus 477 ~~~a~~~l~~l~~~~~~~~~~~~~~~ 502 (529) T 1JDH_A 477 QRVAAGVLCELAQDKEAAEAIEAEGA 502 (529) T ss_dssp HHHHHHHHHHHTTSHHHHHHHHHTTC T ss_pred HHHHHHHHHHHhcCHHHHHHHHHcCc Confidence 99999999999987765544444443 No 19 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=98.42 E-value=4.5e-11 Score=124.53 Aligned_cols=381 Identities=19% Similarity=0.234 Sum_probs=227.1 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 104 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 183 (553) T 3IFQ_A 104 GIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLII 183 (553) T ss_dssp HHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTGGGGTGGGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHhcCChHHHHHHHhcCHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677888889999988876543333333335677788888877778888999999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++.. T Consensus 184 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 247 (553) T 3IFQ_A 184 LANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSN----------------SPRLVQ 247 (553) T ss_dssp HHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHGGGGSS----------------CHHHHH T ss_pred HHCCHHHHHHHHHhcCCcHHHHHHHHHHHHHHhCCcchHHHHHHCchHHHHHHHHhcC----------------CHHHHH Confidence 34456777777776333567888888888888775444333443 6667777666531 233333 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.. ...... ...++++.+...++. .+..-...+...|.++.. T Consensus 248 ~a~~~l~~l~~---------------------~~~~~~---~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 297 (553) T 3IFQ_A 248 NCLWTLRNLSD---------------------VATKQE---GLESVLKILVNQLSV------DDVNVLTCATGTLSNLTC 297 (553) T ss_dssp HHHHHHHHHHT---------------------TCTTCS---CCHHHHHHHHTTTTC------CCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhCC---------------------hhHHHH---HHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHc Confidence 33333322110 000011 112344444433321 111222233333333321 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKDA 563 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~e 563 (747) ... .....+.+.++++.++..+.. ..++. T Consensus 298 ~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~~ 327 (553) T 3IFQ_A 298 NNS--------------------------------------------------KNKTLVTQNSGVEALIHAILRAGDKDD 327 (553) T ss_dssp TCH--------------------------------------------------HHHHHHTTTTHHHHHHHHHHHHTTCHH T ss_pred CCH--------------------------------------------------HHHHHHHHccHHHHHHHHHHHcCCChH Confidence 100 001122345677777776652 14566 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN-SDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d-~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++..... ... ....+...++++.+..++.+.+ +.++..++.+|.+++..... ......++++.+. T Consensus 328 ~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~ 405 (553) T 3IFQ_A 328 ITEPAVCALRHLTSRHPE-AEM-AQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 405 (553) T ss_dssp HHHHHHHHHHHHTSSSTT-HHH-HHHHHHTTTHHHHHHHGGGCTTCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHHH T ss_pred hHHHHHHHHHHHhcCCCh-HHH-HHHHHHHcchHHHHHHHHcCCCChHHHHHHHHHHHHHhcCcccHHHHHHccHHHHHH Confidence 788889999998865321 000 0112234567888888887654 78889999999999876433 2334456778888 Q NP_000290.2 642 RLLTSHTGN---------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 642 ~LL~s~s~~---------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .++...... ......++..++.+|.+++.. +.....+...++++.++.++.+. ++.++..++. T Consensus 406 ~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~ 483 (553) T 3IFQ_A 406 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARD-PMNRMEIFRLNTIPLFVQLLYSS-VENIQRVAAG 483 (553) T ss_dssp HHHHHHHHHHHHHHHTTCCCTTCSSCCHHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHHTTCS-CHHHHHHHHH T ss_pred HHHHHcCcchhHHHhhcccCccccCCCHHHHHHHHHHHHHHHhcC-hhhHHHHHHcCChHHHHHHHhCC-CHHHHHHHHH Confidence 877652100 000027788899999999874 44445555667888888888866 7889999999 Q NP_000290.2 707 LLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 707 aLsnL~~~~~~~~~~~~~~~ 726 (747) +|.+++...+....+.+.|. T Consensus 484 ~l~~l~~~~~~~~~~~~~~~ 503 (553) T 3IFQ_A 484 VLCELAQDKEAADAIDAEGA 503 (553) T ss_dssp HHHHHTTSHHHHHHHHHTTT T ss_pred HHHHHHcCHHHHHHHHHCCc Confidence 99999987766555554443 No 20 >4UAD_A Importin alpha import adaptor, Influenza; importin karyopherin complex NLS, PROTEIN; 2.42A {Homo sapiens} Probab=98.39 E-value=6e-11 Score=121.78 Aligned_cols=372 Identities=17% Similarity=0.175 Sum_probs=218.3 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+ .++.++..++.++..++.........+...++++.+..++.+.+..++..++.++..++......... T Consensus 68 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 147 (479) T 4UAD_A 68 VVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 147 (479) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred hHHHHHHHhhcCCCHHHHHHHHHHHHHHhCCCchHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHH Confidence 45556666654 56778888899998887654333333333567777888887777888899999999887654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI-A-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv-e-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....++.++..++.++..++.......... . ++++.++.++... ++++ T Consensus 148 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 211 (479) T 4UAD_A 148 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSS----------------DSDL 211 (479) T ss_dssp HHHTTCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCSSCCCGGGTGGGHHHHHHHTTCC----------------CHHH T ss_pred HHhCCcHHHHHHHhhcCCchHHHHHHHHHHHHHHcCCCCCchhhcccchHHHHHHHhcCC----------------CHHH Confidence 33345666677766533456788888888888876542222222 1 5666666666431 2333 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... .+ ...+.+ .-.+.+..|...++. .+..-...+...|.++ T Consensus 212 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 264 (479) T 4UAD_A 212 LADACWALSYLSDG------PN--------------EKIQAV-IDSGVCRRLVELLMH------NDYKVASPALRAVGNI 264 (479) T ss_dssp HHHHHHHHHHHTSS------SH--------------HHHHHH-HHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcC------ch--------------HHHHHH-HhCCHHHHHHHHhcC------CCHHhHHHHHHHHHHH Confidence 33333333221100 00 000000 012333333333221 0111111222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) .... ......+.+.++++.|+.++. +.++ T Consensus 265 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 293 (479) T 4UAD_A 265 VTGD--------------------------------------------------DIQTQVILNCSALPCLLHLLS-SPKE 293 (479) T ss_dssp TTSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHTT-CSSH T ss_pred hcCC--------------------------------------------------HHHHHHHHhcChHHHHHHHhh-CCCH Confidence 2100 000112234567888888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+.+.++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++. T Consensus 294 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 368 (479) T 4UAD_A 294 SIRKEACWTISNITAGNRA-----QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKP 368 (479) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHHhccCHHHHHHHHHHHHHHHcCCCHHHHHHHHHcCcHHH Confidence 8888999999999865332 223334557888999999888889999999999999874 222 23344567788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQ-----------YFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~-----------Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) +..++.+ .++.++..++.+|.+++...+..... +.+.+.++.+..++.+. ++.++..++.+| T Consensus 369 l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~-~~~v~~~a~~~l 441 (479) T 4UAD_A 369 LCDLLTV------MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHE-NQEIYQKAFDLI 441 (479) T ss_dssp HHGGGGC------SCHHHHHHHHHHHHHHHHHHHHHTTTTSCCCCTTHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHH T ss_pred HHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhcccCCCCcCHHHHHHHHhchHHHHHHHHhCC-cHHHHHHHHHHH Confidence 8888776 36788889999999998753322111 34445677888888766 788999999999 Q NP_000290.2 709 SDMWSSKELQGVLRQ 723 (747) Q Consensus 709 snL~~~~~~~~~~~~ 723 (747) .+++...+....+.+ T Consensus 442 ~~l~~~~~~~~~~~~ 456 (479) T 4UAD_A 442 EHYFGVEDDDSSLAP 456 (479) T ss_dssp HHHSCC--------- T ss_pred HHhhCCCCCchhccc Confidence 999977665554443 No 21 >5ZHX_D Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF chaperone, ONCOPROTEIN; HET: FAR; 3.5A {Homo sapiens} Probab=98.39 E-value=6.3e-11 Score=120.93 Aligned_cols=407 Identities=17% Similarity=0.217 Sum_probs=228.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP--NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~--d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+..++... ++.++..++.++..++.... ... T Consensus 19 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~v~~~a~~~l~~l~~~~~-~~~ 97 (487) T 5ZHX_D 19 LISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELES-SKE 97 (487) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHTTSTTCHHHHHHHHHTTCHHHHHHHHHHTSSCSHHHHHHHHHHHHHTTSSH-HHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHcccCCCHHHHHHHHHHHHHHHcchh-HHH Confidence 556677777777888999999999998875544444444556778888888765 77888899999998876532 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) .+...++++.+...+....++.++..++.++..++........+.. ++++.|..++....... .....+. T Consensus 98 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~---------~~~~~~~ 168 (487) T 5ZHX_D 98 QFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD---------KEDDITE 168 (487) T ss_dssp HHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSHHHHHHHHHHTHHHHHHHHHHHTSSCC---------CHHHHHH T ss_pred HHhhCCHHHHHHHHHHhccChHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHHHhcCCCC---------CHHHHHH Confidence 3334467777888776222677888899999998876444444444 67777777776432100 0000000 Q NP_000290.2 403 FFNATGCLR----------KRL------GMRELLALVPQ-------RATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 403 ~~~~~~~~~----------~~~------~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 459 (747) +..+...+. +-+ -+..++.+... .+...-.+++..+..+..+.. .+.++.+...+. T Consensus 169 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~ 247 (487) T 5ZHX_D 169 LKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVD-NGIVEKLMDLLD 247 (487) T ss_dssp HHHHHHHHHHHTTSHHHHHHHSSSSSSSHHHHHHTTTTSSCHHHHHHHHHHHHHHCCSHHHHHHHHT-TTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHhhCCCchHHHHHHHHccCCCHHHHHHHHHHHHHHHcCchHHHHHHh-cCHHHHHHHHHH Confidence 000000000 000 00111111100 000000011111111111000 011222211111 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) .... .-+..-...+..+|.|+. .. . .. T Consensus 248 ~~~~--~~~~~~~~~a~~~l~~l~-----------------------------------~~---------------~-~~ 274 (487) T 5ZHX_D 248 RHVE--DGNVTVQHAALSALRNLA-----------------------------------IP---------------V-IN 274 (487) T ss_dssp HTSS--SSCHHHHHHHHHHHHHHT-----------------------------------CS---------------H-HH T ss_pred hccc--CCCHHHHHHHHHHHHHhc-----------------------------------CC---------------h-hh Confidence 0000 000000111111111111 00 0 01 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASL 618 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-eVr~~AL~a 618 (747) ...+.+.++++.++.++. +.++.++..++++|.+++...+. . ........++++.++.++.+.+. .++..++++ T Consensus 275 ~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~ 349 (487) T 5ZHX_D 275 KAKMLSAGVTEAVLKFLK-SEMPPVQFKLLGTLRMLIDAQAE---A-AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRL 349 (487) T ss_dssp HHHHHHHTHHHHHHTTSS-CCCHHHHHHHHHHHHHHTSSCHH---H-HHHHHHCHHHHHHHHHHHTCCSCCHHHHHHHHH T ss_pred HHHHHHcChHHHHHHHHh-CCCHHHHHHHHHHHHHHHhhcHH---H-HHHhccccCHHHHHHHHHHhcCchhhHHHHHHH Confidence 122345678888888888 46788888999999999875332 1 11221224678888888887665 888999999 Q NP_000290.2 619 LSNMSRHPL---L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~~~e---~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++.... . ..+...++++.+..++.. .++.++..++.+|.+++...+ .....+.+.++++.++.++. T Consensus 350 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 423 (487) T 5ZHX_D 350 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATS------EHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLA 423 (487) T ss_dssp HHHHHHHHCCHHHHHHHHHHTCHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHTS T ss_pred HHHHHHHhcchhHHHHHHHcchHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCCCchHHHHhhhhHHHHHHHHHh Confidence 999986522 2 233445677888888776 367889999999999987542 23333444457888888887 Q NP_000290.2 694 SS-ASPKAAEAARLLLSDMWSSKELQGVLRQQGFD 727 (747) Q Consensus 694 s~-~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~~ 727 (747) .. .++.++..++.+|.+++...+....+...|+- T Consensus 424 ~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~ 458 (487) T 5ZHX_D 424 DERSAPEIKYNSMVLICALMGSECLHKEVQDLAFL 458 (487) T ss_dssp SSCCSTTCTHHHHHHHHTSCSSSCCSTTTTTHHHH T ss_pred cccCcHHHHHHHHHHHHHHhCcHHHHHHHHHhchH Confidence 32 15788999999999999887766666555543 No 22 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=98.36 E-value=8.2e-11 Score=117.69 Aligned_cols=364 Identities=16% Similarity=0.224 Sum_probs=221.8 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.++..++......... T Consensus 3 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 82 (423) T 1EE4_A 3 LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKV 82 (423) T ss_dssp HHHHHHHHTCSCHHHHHHHHHHHHHHHCCSSSCSHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred hHHHHHHhccccHHHHHHHHHHHHHHHhCCCCCchHHHHhcChHHHHHHHhhcCCcHHHHHHHHHHHHHHhCCCHHHHHH Confidence 44566666777788888888888888754321 2222333456777777776543 667888899998887644333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++... ++++ T Consensus 83 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 145 (423) T 1EE4_A 83 VVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSL 145 (423) T ss_dssp HHHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC----------------CHHH T ss_pred HHhCChHHHHHHHHh-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHH Confidence 333456777777776 5677888899999998886532 2223333 6667776666421 2344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... ...........+++..|...+.. .+......+...|.++ T Consensus 146 ~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l 198 (423) T 1EE4_A 146 IRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYL 198 (423) T ss_dssp HHHHHHHHHHHHCC---------------------STTCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHcC---------------------CCCCCChHHHhhHHHHHHHHHHc------CCHHHHHHHHHHHHHH Confidence 44444443321100 00000111122334433333221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ... +......+.+.++++.+..++. +.++ T Consensus 199 ~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~ 227 (423) T 1EE4_A 199 SDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HEST 227 (423) T ss_dssp TSS--------------------------------------------------CHHHHHHHHHTTHHHHHHHHTT-CSCH T ss_pred hcC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCc Confidence 110 0001112234567778888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++.+ T Consensus 228 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l 302 (423) T 1EE4_A 228 LVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL 302 (423) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHH T ss_pred chhHHHHHHHHHHHhCChH-----HHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHH Confidence 8888999999998865332 122333457888888888888888999999999999875 222 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ---PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s---~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 303 ~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~~ 375 (423) T 1EE4_A 303 VKLLEV------AEDKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHHH------SCHHHHHHHHHHHHHHHGGGGTCHHHHHHHHHTTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhc------CCHHHHHHHHHHHHHHHcCCCCcHHHHHHHHHCCCHHHHHHHHhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 888766 36788999999999998753 23334444456788888888876 788999999999999876554 No 23 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=98.36 E-value=8.2e-11 Score=117.69 Aligned_cols=364 Identities=16% Similarity=0.224 Sum_probs=221.8 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.++..++......... T Consensus 3 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 82 (423) T 1EE4_B 3 LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKV 82 (423) T ss_dssp HHHHHHHHTSSCHHHHHHHHHHHHHHHCCSSSCCHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred hHHHHHHhccccHHHHHHHHHHHHHHHhCCCCCchHHHHhcChHHHHHHHhhcCCcHHHHHHHHHHHHHHhCCCHHHHHH Confidence 44566666777788888888888888754321 2222333456777777776543 667888899998887644333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++... ++++ T Consensus 83 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 145 (423) T 1EE4_B 83 VVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSL 145 (423) T ss_dssp HHHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSC----------------CHHH T ss_pred HHhCChHHHHHHHHh-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHH Confidence 333456777777776 5677888899999998886532 2223333 6667776666421 2344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... ...........+++..|...+.. .+......+...|.++ T Consensus 146 ~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l 198 (423) T 1EE4_B 146 IRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYL 198 (423) T ss_dssp HHHHHHHHHHHHCC---------------------SSSCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHcC---------------------CCCCCChHHHhhHHHHHHHHHHc------CCHHHHHHHHHHHHHH Confidence 44444443321100 00000111122334433333221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ... +......+.+.++++.+..++. +.++ T Consensus 199 ~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~ 227 (423) T 1EE4_B 199 SDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HEST 227 (423) T ss_dssp HSS--------------------------------------------------CHHHHHHHHHTTHHHHHHHHTT-CSCH T ss_pred hcC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCc Confidence 110 0001112234567778888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++.+ T Consensus 228 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l 302 (423) T 1EE4_B 228 LVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL 302 (423) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHH T ss_pred chhHHHHHHHHHHHhCChH-----HHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHH Confidence 8888999999998865332 122333457888888888888888999999999999875 222 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ---PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s---~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 303 ~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~~ 375 (423) T 1EE4_B 303 VKLLEV------AEDKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHHH------SCHHHHHHHHHHHHHHHGGGGTCTHHHHHHHHTTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhc------CCHHHHHHHHHHHHHHHcCCCCcHHHHHHHHHCCCHHHHHHHHhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 888766 36788999999999998753 23334444456788888888876 788999999999999876554 No 24 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=98.34 E-value=9.8e-11 Score=121.45 Aligned_cols=382 Identities=19% Similarity=0.227 Sum_probs=226.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 103 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 182 (538) T 4EV8_A 103 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLII 182 (538) T ss_pred cHHHHHHHhCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45556666666677888889999988876543333333345677788888877778888999999998886444333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++.. T Consensus 183 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 246 (538) T 4EV8_A 183 LASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLVQ 246 (538) T ss_pred HHCChHHHHHHHHcCCCCHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhcCC----------------CHHHHH Confidence 44457777777776333567788888888888765444333433 6667777666432 233333 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.. .......+ .+.+..+...+.. .+..-...+...|.++.. T Consensus 247 ~a~~~l~~l~~---------------------~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 296 (538) T 4EV8_A 247 NCLWTLRNLSD---------------------AATKQEGM---EGLLGTLVQLLGS------DDINVVTCAAGILSNLTC 296 (538) T ss_pred HHHHHHHHHHc---------------------CCCchHHH---cCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHc Confidence 33333322110 00000001 2333333333321 111112222222333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKDA 563 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~e 563 (747) .- ......+.+.++++.++..+.. ..++. T Consensus 297 ~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~~ 326 (538) T 4EV8_A 297 NN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRED 326 (538) T ss_pred CC--------------------------------------------------HHHHHHHHHCCcHHHHHHHHhcCCCCHH Confidence 00 0011122455677777776652 14566 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++..... .......+...++++.|..++.+. +..++..++.+|.+++..... ..+...++++.+. T Consensus 327 ~~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~ 404 (538) T 4EV8_A 327 ITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLV 404 (538) T ss_pred HHHHHHHHHHHHHcCCCC--hHHHHHHHHHCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHH Confidence 778899999998865331 000012223457788888888765 678889999999999876433 3344556778888 Q NP_000290.2 642 RLLTSHTGNT----------------SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 642 ~LL~s~s~~~----------------~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .++....... ...+.++..++.+|.+++.. ......+...++++.++.++.+. ++.++..++ T Consensus 405 ~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~ 482 (538) T 4EV8_A 405 QLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD-VHNRIVIRGLNTIPLFVQLLYSP-IENIQRVAA 482 (538) T ss_pred HHHcCCCcchhhhhccCchHHHHHhcCCCHHHHHHHHHHHHHHhCC-cchhHHHHHcChHHHHHHHhcCC-CHHHHHHHH Confidence 7776521000 00156677899999999875 33344445556788888888876 788999999 Q NP_000290.2 706 LLLSDMWSSKELQGVLRQQGFD 727 (747) Q Consensus 706 ~aLsnL~~~~~~~~~~~~~~~~ 727 (747) .+|.+++...+....+.+.|+- T Consensus 483 ~~l~~l~~~~~~~~~~~~~~~~ 504 (538) T 4EV8_A 483 GVLCELAQDKEAAEAIEAEGAT 504 (538) T ss_pred HHHHHHHcCHHHHHHHHHCCcH Confidence 9999999877665555544443 No 25 >4RXH_B Importin subunit alpha, Large T; ARM repeat, NLS, nuclear import; 1.7553A {Neurospora crassa} Probab=98.34 E-value=1.1e-10 Score=121.65 Aligned_cols=365 Identities=17% Similarity=0.175 Sum_probs=215.9 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.......... T Consensus 72 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~ 151 (495) T 4RXH_B 72 VVGRFVEFLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPDVREQAVWALGNIAGDSPQCRDYV 151 (495) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhCCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHHH Confidence 45566666666777888889999988876543333333345677788888887778889999999998886533333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+....++.++..++.++..++........ ... ++++.+..++..+ ++++- T Consensus 152 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 215 (495) T 4RXH_B 152 LSCGALRPLLTLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLVYSL----------------DDEVL 215 (495) T ss_dssp HHTTCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCTTCCCHHHHTTHHHHHHHHTTCS----------------SHHHH T ss_pred HhCCcHHHHHHHhccccCHHHHHHHHHHHHHHhCCCCCCCcHHhhcCHHHHHHHHhhCC----------------CHHHH Confidence 33456777777775333567888889999988875422211 112 5666666666431 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .........---.+++..|...++. .+..-...+...|.++. T Consensus 216 ~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 268 (495) T 4RXH_B 216 IDACWAISYLS---------------------DGSNDKIQAVIEAGIPRRLVELLMH------ASTSVQTPALRSVGNIV 268 (495) T ss_dssp HHHHHHHHHHT---------------------SSCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------cCCHHHHHHHHHCChHHHHHHHHhc------CCccHHHHHHHHHHHHh Confidence 33333332110 0000000000011344444443321 01111122222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.++.++. +.++. T Consensus 269 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~ 297 (495) T 4RXH_B 269 TGD--------------------------------------------------DVQTQVIINCGALPCLLSLLS-SNKDG 297 (495) T ss_dssp TSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSCHH T ss_pred cCC--------------------------------------------------HHHHHHHHhCCHHHHHHHHHh-CCCHH Confidence 100 001112234567778888887 46778 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP----LL-HRVMGNQVFP 638 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~----e~-~~ll~~giI~ 638 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++... .. ..+...++++ T Consensus 298 v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~ 372 (495) T 4RXH_B 298 IRKEACWTISNITAGNSA-----QIQSVIDANIIPPLIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIK 372 (495) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHTTTTTTTCTHHHHHHHHTTCHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCCCHHHHHHHHHCCCHH Confidence 888899999998764332 1223344578888888888778888889999999988752 11 2233446777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL--------------AKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~--------------~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) .+..++.+ .++.++..++.+|.+++...... ...+.+.++++.|..++.+. ++.++..+ T Consensus 373 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a 445 (495) T 4RXH_B 373 PLCDLLAC------PDNKIIQVALDGLENILKVGELDKNAAGDGPDSINRYALFIEECGGMEKIHDCQTNA-NEEIYMKA 445 (495) T ss_dssp HHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHHHTC-----CCCHHHHHHHHTTHHHHHHHGGGCC-SSTTHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhhHccccCCCCCchHHHHHHHHHHccchHHHHHhhhcC-CHHHHHHH Confidence 77777766 36778888999999888753211 22333455677788888766 78899999 Q NP_000290.2 705 RLLLSDMWSSKE 716 (747) Q Consensus 705 L~aLsnL~~~~~ 716 (747) +.+|.+++...+ T Consensus 446 ~~~l~~l~~~~~ 457 (495) T 4RXH_B 446 YNIIEKYFSDED 457 (495) T ss_dssp HHHHHHHCC--- T ss_pred HHHHHHhcCccc Confidence 999999886544 No 26 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=98.32 E-value=1.2e-10 Score=118.46 Aligned_cols=366 Identities=17% Similarity=0.164 Sum_probs=217.0 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.+..++..++.++..++......... T Consensus 46 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 125 (456) T 4BQK_A 46 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 125 (456) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhccCcCHHHHHHHHHHHHHHhcCCHhHHHHHHhccHHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 4455566665543 778888899998887554443333444567778888887777888899999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+.+..++..+....++.++..++.++..++........... ++++.|..++... ++++- T Consensus 126 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 189 (456) T 4BQK_A 126 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHSN----------------DEEVL 189 (456) T ss_dssp HHHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTCC----------------CHHHH T ss_pred HHHCCcHHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHhcCC----------------CHHHH Confidence 333455666666665334567888888888888775433222222 5666666666431 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ..+ ..++.. .-.+++..|...+.. .+..-...+...|.++. T Consensus 190 ~~a~~~l~~l~~------~~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 242 (456) T 4BQK_A 190 TDACWALSYLSD------GTN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 242 (456) T ss_dssp HHHHHHHHHHTS------SSH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhc------CCh--------------HHHHHH-HHCChHHHHHHHHhC------CCHHHHHHHHHHHHHHH Confidence 333333322110 000 000000 012334444333321 11111222222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.++.++....++. T Consensus 243 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 272 (456) T 4BQK_A 243 TGD--------------------------------------------------DAQTQCIIDHQALPCLLSLLTQNLKKS 272 (456) T ss_dssp TSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHHHSCCCHH T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHHcCCCHH Confidence 100 000112244567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++.+ T Consensus 273 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 347 (456) T 4BQK_A 273 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 347 (456) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHHTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHhcCCHH-----HHHHHHHCCcHHHHHHHhhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888899999888888999999999999875 222 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-----------AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-----------~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++...+.. ...+.+.+.++.+..++.+. ++.++..++.+|. T Consensus 348 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l~ 420 (456) T 4BQK_A 348 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 420 (456) T ss_dssp HHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHTTCSCCHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHH T ss_pred HHHhhC------CChHHHHHHHHHHHHHHHHhhhchhccCCCCCHHHHHHHHcchHHHHHHHHcCC-CHHHHHHHHHHHH Confidence 888776 36788899999999998753321 11122245677788888766 7889999999999 Q NP_000290.2 710 DMWSSKE 716 (747) Q Consensus 710 nL~~~~~ 716 (747) +++...+ T Consensus 421 ~l~~~~~ 427 (456) T 4BQK_A 421 AYWMDEE 427 (456) T ss_dssp HHCC--- T ss_pred HHhcCcc Confidence 9887544 No 27 >6BW9_A Importin subunit alpha-3, Protein W; Complex, Hendra virus, Importin, Karyopherin; 1.6A {Homo sapiens} Probab=98.31 E-value=1.3e-10 Score=118.46 Aligned_cols=366 Identities=17% Similarity=0.199 Sum_probs=218.4 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++......... T Consensus 53 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 132 (459) T 6BW9_A 53 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 132 (459) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHhhCCHHHHHHHHhcCCChHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665 456778888899998887654433333344567778888887777888999999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEEL-I-ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~L-v-egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++......... . .++++.+..++.. .++++ T Consensus 133 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~v 196 (459) T 6BW9_A 133 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHH----------------TDVNI 196 (459) T ss_dssp HHHTTCHHHHHHTCSTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTC----------------CCHHH T ss_pred HHHCCcHHHHHhccCCCCCHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhc----------------CCHHH Confidence 3334566777777653345567888888888887643321111 1 1566666666543 13344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-... .+ ...... -..+++..|...++. .+..-...++..|.++ T Consensus 197 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 249 (459) T 6BW9_A 197 LVDTVWALSYLTDA------GN--------------EQIQMV-IDSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 249 (459) T ss_dssp HHHHHHHHHHHHTS------CH--------------HHHHHH-HHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhc------Ch--------------HHHHHH-HhCChHHHHHHHcCC------CCHHHHHHHHHHHHHH Confidence 44444333221100 00 000000 012334444333321 1111122223333333 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ....+ .....+.+.++++.++.++. +.++ T Consensus 250 ~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~~~ 278 (459) T 6BW9_A 250 VTGTD--------------------------------------------------EQTQVVLNCDALSHFPALLT-HPKE 278 (459) T ss_dssp TTSCH--------------------------------------------------HHHHHHHTTTGGGGCHHHHT-CSCH T ss_pred HcCCH--------------------------------------------------HHHHHHhcccchhcHHHHhh-CCCH Confidence 21100 00111234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ......++++. T Consensus 279 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 353 (459) T 6BW9_A 279 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 353 (459) T ss_dssp HHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHcCCCHH-----HHHHHHHCCHHHHHHHHHHhCCHHHHHHHHHHHHHHHHhCCHHHHHHHHHCCcHHH Confidence 8888999999999865332 223334557888888888888888999999999999864 2 21 23334467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) +..++.+ .++.++..++.+|.+++...+... ..+...++++.+..++.+. ++.++..++.+|.+++... T Consensus 354 l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 426 (459) T 6BW9_A 354 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 426 (459) T ss_dssp HHGGGGC------SCHHHHHHHHHHHHHHHHHCTTTHHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHSCC- T ss_pred HHHhcCC------CCHHHHHHHHHHHHHHHHHhHhhHHHHHHHHHHcCHHHHHHHHhcCC-CHHHHHHHHHHHHHHcCCC Confidence 8888776 367888999999999987533221 1233346778888888766 7889999999999998766 Q NP_000290.2 716 EL 717 (747) Q Consensus 716 ~~ 717 (747) +. T Consensus 427 ~~ 428 (459) T 6BW9_A 427 DI 428 (459) T ss_dssp -- T ss_pred CC Confidence 54 No 28 >1WA5_B GTP-BINDING NUCLEAR PROTEIN RAN, IMPORTIN; NUCLEAR TRANSPORT-COMPLEX, NUCLEAR TRANSPORT, EXPORTIN; HET: GTP; 2.0A {CANIS FAMILIARIS} SCOP: a.118.1.1 Probab=98.27 E-value=1.9e-10 Score=121.37 Aligned_cols=134 Identities=13% Similarity=0.098 Sum_probs=85.4 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...++++.+..++.+.+..++..++.++..++......... T Consensus 173 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 252 (530) T 1WA5_B 173 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 252 (530) T ss_dssp TCHHHHHHHHHHCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSCCHHHHHHHHHHHHHHHCCSSSCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCCCCCCH Confidence 34556666676777888899999999988654433334444567778888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRV 379 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL 379 (747) ....++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|+.++ T Consensus 253 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l 308 (530) T 1WA5_B 253 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELL 308 (530) T ss_dssp HHHGGGHHHHHHHTT-CCCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTCHHHHHHGG T ss_pred HHHhhHHHHHHHHHh-cCCHHHHHHHHHHHHHHcCCCHHHHHHHHhCCHHHHHHHHh Confidence 223456666777765 4566777778888887776422 2222222 4455555544 No 29 >5XGC_A Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF, ONCOPROTEIN; 2.1A {Homo sapiens} Probab=98.27 E-value=2e-10 Score=117.66 Aligned_cols=409 Identities=17% Similarity=0.214 Sum_probs=224.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS--PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s--~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.. .++.++..++.++..++.... ... T Consensus 35 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~-~~~ 113 (503) T 5XGC_A 35 LISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELES-SKE 113 (503) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHSCCCSHHHHHHHHHTTHHHHHHHHHHHTTTCHHHHHHHHHHHHHHTTSHH-HHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCchHHHHHHHCChHHHHHHHHhccCCCHHHHHHHHHHHHHHHccHH-HHH Confidence 55666777777778889999999999887543333344445677788888776 467888889999988876532 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) .+...++++.+...+....++.++..++.++..++........+.. ++++.++.++....... + ....+. T Consensus 114 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~--------~-~~~~~~ 184 (503) T 5XGC_A 114 QFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD--------K-EDDITE 184 (503) T ss_dssp HHTTTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSHHHHHHHHHTTHHHHHHHHHHHHTTCC--------C-HHHHHH T ss_pred HHhcCCHHHHHHHHHHhcCChhHHHHHHHHHHHHHcCHHHHHHHHHCCHHHHHHHHHHhcCCCC--------C-HHHHHH Confidence 2334466777777776222677888899999998876444444444 67777777776432100 0 000000 Q NP_000290.2 403 FFNATGCLRKRL----------------GMRELLALVPQR-------ATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 403 ~~~~~~~~~~~~----------------~~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 459 (747) +..+...+..-. -+..++.+.... +...-.+++..+..+..+.. .|.++.|+..+. T Consensus 185 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~-~~~~~~l~~~l~ 263 (503) T 5XGC_A 185 LKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVD-NGIVEKLMDLLD 263 (503) T ss_dssp HHHHHHHHHHHTTSHHHHHHHHGGGTCHHHHHHHHHTTSSCHHHHHHHHHHHHHHCSSHHHHHHHHH-TTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhCCchHHHHHhcCcccHHHHHHHHccCCCHHHHHHHHHHHHHHHCChhHHHHHHH-CCHHHHHHHHHH Confidence 000000000000 000111110000 00000011111111110000 011222221111 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) .... .-+..-...++.+|.++. .. . .. T Consensus 264 ~~~~--~~~~~~~~~a~~~l~~l~-----------------------------------~~---------------~-~~ 290 (503) T 5XGC_A 264 RHVE--DGNVTVQHAALSALRNLA-----------------------------------IP---------------V-IN 290 (503) T ss_dssp TTTT--TCCHHHHHHHHHHHHHHT-----------------------------------CS---------------H-HH T ss_pred hccc--cCCHHHHHHHHHHHHHhc-----------------------------------CC---------------H-HH Confidence 1000 000000011111111111 00 0 01 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASL 618 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-eVr~~AL~a 618 (747) ...+.+.++++.|..++. +.++.++..++.+|.+++...+. . ........++++.+..++.+.+. .++..++++ T Consensus 291 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~---~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~ 365 (503) T 5XGC_A 291 KAKMLSAGVTEAVLKFLK-SEMPPVQFKLLGTLRMLIDAQAE---A-AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRL 365 (503) T ss_dssp HHHHHHHTHHHHHHTTTT-CCCHHHHHHHHHHHHHHTTTCHH---H-HHHHHTCHHHHHHHHHHHTCTTCHHHHHHHHHH T ss_pred HHHHHHcCHHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH---H-HHHHccccchHHHHHHHHccCCccchHHHHHHH Confidence 122345678888888888 46778888999999999875332 0 11221235678888888877665 888999999 Q NP_000290.2 619 LSNMSRHPL---L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~~~e---~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+ .....+...++++.+...+. T Consensus 366 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 439 (503) T 5XGC_A 366 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATS------EHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLA 439 (503) T ss_dssp HHHHHHHHCCHHHHHHHHHHTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHC-- T ss_pred HHHHHHHccChhHHHHHHhcChHHHHHHHhcC------CCHHHHHHHHHHHHHHHhCCCCcHHHHHHhccHHHHHHHHHh Confidence 999976522 2 233455677888888876 367889999999999987542 22333444457888888887 Q NP_000290.2 694 SS-ASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRN 729 (747) Q Consensus 694 s~-~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~~~~ 729 (747) .. .++.++..++.+|.+++...+....+...|+..- T Consensus 440 ~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 476 (503) T 5XGC_A 440 DERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDV 476 (503) T ss_dssp -----CGGGGHHHHHHHHHTTCSSCCCSGGGTHHHHH T ss_pred CCCCcHHHHHHHHHHHHHHhCCHHHHHHHHHhcHHHH Confidence 32 1578899999999999988776666655555443 No 30 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=98.24 E-value=2.4e-10 Score=115.88 Aligned_cols=367 Identities=17% Similarity=0.164 Sum_probs=216.2 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+...+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 44 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 123 (454) T 4BPL_A 44 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 123 (454) T ss_dssp CHHHHHHHHSCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred cHHHHHHHhccCcCHHHHHHHHHHHHHHhcCChhhhHHHhhccHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4455566665543 778888889998887544433333444567778888887777888999999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+.+..++..+....++.++..++.++..++........... ++++.|..++.. -++++. T Consensus 124 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~ 187 (454) T 4BPL_A 124 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHS----------------NDEEVL 187 (454) T ss_dssp HHHTTCHHHHHHTCSTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTC----------------CCHHHH T ss_pred HHHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHhC----------------CCHHHH Confidence 333455666666665334567888888888888765433222222 566666666542 123444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-... .+ ..++.. -..+++..|...++. .+..-...+...|.++. T Consensus 188 ~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 240 (454) T 4BPL_A 188 TDACWALSYLSDG------TN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 240 (454) T ss_dssp HHHHHHHHHHTSS------CH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhcC------Ch--------------HHHHHH-HHCCcHHHHHHHhhC------CChHHHHHHHHHHHHHh Confidence 4444333221100 00 000000 012334444333321 01111122222222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) .. +......+.+.++++.++.++....++. T Consensus 241 ~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~~~~~~~ 270 (454) T 4BPL_A 241 TG--------------------------------------------------DDAQTQCIIDHQALPCLLSLLTQNLKKS 270 (454) T ss_dssp TS--------------------------------------------------CHHHHHHHHTTTHHHHHHHHHHSSCCHH T ss_pred cC--------------------------------------------------CHHHHHHHHHCChHHHHHHHHHhcCCHH Confidence 10 0001112234567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++.+ T Consensus 271 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 345 (454) T 4BPL_A 271 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 345 (454) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHHTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHhcCCHH-----HHHHHHhCCcHHHHHHHhhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888899999888888999999999999875 222 233444677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-----------KQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-----------~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++....... ..+.+.+.++.+..++.+. ++.++..++.+|. T Consensus 346 ~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~ 418 (454) T 4BPL_A 346 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 418 (454) T ss_dssp HHTTTC------SCHHHHHHHHHHHHHHHHHHHHHHHHHTCSSCHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHH T ss_pred HHHhcC------CChHHHHHHHHHHHHHHHHhhhchhcccCCCCHHHHHHHHcccHHHHHHHHcCC-CHHHHHHHHHHHH Confidence 888776 367888899999999987532211 1112245677788888766 7889999999999 Q NP_000290.2 710 DMWSSKEL 717 (747) Q Consensus 710 nL~~~~~~ 717 (747) .+....+. T Consensus 419 ~l~~~~~~ 426 (454) T 4BPL_A 419 AYWMDEED 426 (454) T ss_dssp HHCC---- T ss_pred HHhcCccc Confidence 99876544 No 31 >4B8J_A IMPORTIN SUBUNIT ALPHA-1A; TRANSPORT PROTEIN, NUCLEAR LOCALIZATION SIGNAL; 2.001A {ORYZA SATIVA JAPONICA GROUP} Probab=98.24 E-value=2.6e-10 Score=119.98 Aligned_cols=367 Identities=17% Similarity=0.160 Sum_probs=217.7 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.+|..++.........+...++++.+..++.+.+..++..++.+|..++......... T Consensus 118 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 197 (528) T 4B8J_A 118 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 197 (528) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665544 778888999998887544433333444557778888887777888899999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..++..+....++.++..++.++..++........... ++++.|..++.. .++++. T Consensus 198 ~~~~~~l~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~v~ 261 (528) T 4B8J_A 198 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHS----------------NDEEVL 261 (528) T ss_dssp HHHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTC----------------CCHHHH T ss_pred HHHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCCCCCHHHHhhHHHHHHHHhcC----------------CCHHHH Confidence 333455666666664334567888888999888875433222222 566666666643 133444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-.. ..+ ...+.+ ...++++.|+..++. .+..-...+...|.++. T Consensus 262 ~~a~~~l~~l~~------~~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 314 (528) T 4B8J_A 262 TDACWALSYLSD------GTN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 314 (528) T ss_dssp HHHHHHHHHHTS------SCH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhc------CCh--------------HHHHHH-HHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 444443322110 000 000000 012344444433321 01111122222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.|+.++....++. T Consensus 315 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 344 (528) T 4B8J_A 315 TGD--------------------------------------------------DAQTQCIIDHQALPCLLSLLTQNLKKS 344 (528) T ss_dssp TSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHHHSCCCHH T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHhcCCCHH Confidence 100 001112245567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++.| T Consensus 345 v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 419 (528) T 4B8J_A 345 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 419 (528) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCchHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888999999888888999999999999875 2 22 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-----------AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-----------~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++...... ...+.+.++++.|..++.+. ++.++..|+.+|. T Consensus 420 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l~ 492 (528) T 4B8J_A 420 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 492 (528) T ss_dssp HHGGGC------SCHHHHHHHHHHHHHHHHHHHHHHHHHTCSCCHHHHHHHHTTHHHHHHHGGGCS-SHHHHHHHHHHHH T ss_pred HHHccC------CCHHHHHHHHHHHHHHHHHhHHcHhhcCCCCcHHHHHHHHcCHHHHHHHHhcCC-CHHHHHHHHHHHH Confidence 888776 36788899999999998753221 11122345677788888766 7889999999999 Q NP_000290.2 710 DMWSSKEL 717 (747) Q Consensus 710 nL~~~~~~ 717 (747) +++...+. T Consensus 493 ~l~~~~~~ 500 (528) T 4B8J_A 493 AYWMDEED 500 (528) T ss_dssp HHCC---- T ss_pred Hhcccccc Confidence 98875544 No 32 >5T94_B Guanine nucleotide exchange factor SRM1; Nuclear Import, Importin alpha, RCC1; 2.631A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.23 E-value=2.9e-10 Score=120.53 Aligned_cols=364 Identities=15% Similarity=0.171 Sum_probs=219.0 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+.+.+ +.++..++.+|..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 131 ~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 210 (542) T 5T94_B 131 VVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDY 210 (542) T ss_dssp CHHHHHHTTSSSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred hHHHHHHHhhcCCCHHHHHHHHHHHHHHHcCChHHHHHHhcCChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 4555666665443 677888899998887654333333334567777888887777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+..++. ..++.++..++.+|..++.... ....... ++++.|+.++.. .++++ T Consensus 211 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~ 273 (542) T 5T94_B 211 VLQCNAMEPILGLFN-SNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYS----------------MDTET 273 (542) T ss_dssp HHHTTCHHHHHHGGG-CCCHHHHHHHHHHHHHHSCCSTTCCCHHHHGGGHHHHHHHTTC----------------CCHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCCCCCCHHHHhcHHHHHHHHHhc----------------CCHHH Confidence 344467777777776 5567788889999998887542 2222222 566777766642 12334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... -+ ...+.+. -.+++..|...++. .+..-...+...|.++ T Consensus 274 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l 326 (542) T 5T94_B 274 LVDACWAISYLSDG------PQ--------------EAIQAVI-DVRIPKRLVELLSH------ESTLVQTPALRAVGNI 326 (542) T ss_dssp HHHHHHHHHHHSSS------SH--------------HHHHHHH-HTTCHHHHHHTTSC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHcCC------CH--------------HHHHHHH-hCCHHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33333333221100 00 0000000 01233333322221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|+.++. +.++ T Consensus 327 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 355 (542) T 5T94_B 327 VTGN--------------------------------------------------DLQTQVVINAGVLPALRLLLS-SPKE 355 (542) T ss_dssp TTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSSH T ss_pred HcCC--------------------------------------------------HHHHHHHHHCChHHHHHHHhh-CCCH Confidence 2100 001111234567888888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL----L-HRVMGNQVF 637 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e----~-~~ll~~giI 637 (747) .++..++++|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++.... . ..+...+++ T Consensus 356 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 430 (542) T 5T94_B 356 NIKKEACWTISNITAGNTE-----QIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCI 430 (542) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHGGGTTCTHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCchHHHHHHHHcCCHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCH Confidence 8888999999999875332 23333456788888888888888899999999999987621 1 223345678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-----------LAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-----------~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) +.|..++.+ .++.++..++.+|.+++...+. ....+.+.++++.|..++.+. ++.++..|+. T Consensus 431 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ll~~~-~~~v~~~a~~ 503 (542) T 5T94_B 431 KPLCDLLEI------ADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNE-NDKIYEKAYK 503 (542) T ss_dssp HHHHHHHHH------CCHHHHHHHHHHHHHHHHHHHHHTTTTTCSSCTTTHHHHHTTCHHHHHTTSSSC-CHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHcCCCccHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHH Confidence 888888876 3677888999999999875332 123344456788888888766 7889999999 Q NP_000290.2 707 LLSDMWSSKE 716 (747) Q Consensus 707 aLsnL~~~~~ 716 (747) +|.+++...+ T Consensus 504 ~l~~l~~~~~ 513 (542) T 5T94_B 504 IIETYFGEEE 513 (542) T ss_dssp HHHHHC---- T ss_pred HHHHHhCcCc Confidence 9999987543 No 33 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=98.21 E-value=3.2e-10 Score=119.57 Aligned_cols=369 Identities=17% Similarity=0.184 Sum_probs=220.4 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 119 ~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 198 (531) T 4TNM_A 119 VVPRVVKFLSRDDFPKLQFEAAWALTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKCRDL 198 (531) T ss_pred CHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCCHHHHHHHccCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665544 778888889998887644333333444567778888887777888999999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..+...+....+..++..++.++..++........... ++++.|..++... ++++. T Consensus 199 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 262 (531) T 4TNM_A 199 VLSYGAMTPLLSQFNENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPALPVLERLVQSM----------------DEEVL 262 (531) T ss_pred HHHCCCHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCCCCcchhhhcchHHHHHHHhcCC----------------CHHHH Confidence 333456666666664334567888888898888765433222222 5666666665431 33444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-.. .+......-.-.+++..|...+.. .+..-...+...|.++. T Consensus 263 ~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~ 315 (531) T 4TNM_A 263 TDACWALSYLSD---------------------NSNDKIQAVIEAGVVPRLIQLLGH------SSPSVLIPALRTIGNIV 315 (531) T ss_pred HHHHHHHHHHhC---------------------CCHHHHHHHHHCChHHHHHHHHhC------CCHHHHHHHHHHHHHHH Confidence 444433322110 000000000012334444333321 11112222233333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ .....+.+.++++.|+.++....++. T Consensus 316 ~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~ 345 (531) T 4TNM_A 316 TGDD--------------------------------------------------LQTQMVLDQQALPCLLNLLKNNYKKS 345 (531) T ss_pred CCCH--------------------------------------------------HHHHHHHHCCcHHHHHHHhcCCCCHH Confidence 1100 00111234467788888887323567 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PL-L-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e-~-~~ll~~giI~~L 640 (747) ++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++.. .. . ..+...++++.| T Consensus 346 v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 420 (531) T 4TNM_A 346 IKKEACWTISNITAGNAD-----QIQAVIDAGIIQSLVWVLQSAEFEVKKEAAWGISNATSGGTHDQIKFMVSQGCIKPL 420 (531) T ss_pred HHHHHHHHHHHHHCCCHH-----HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCcHHHH Confidence 888999999999875332 233334566888888888887888999999999999875 21 2 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ------------PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s------------~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ..++.+ .++.++..++.+|.+++... ......+.+.++++.|..++.+. ++.++..|+.+| T Consensus 421 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l 493 (531) T 4TNM_A 421 CDLLTC------PDLKVVTVCLEALENILVVGEAEKNLGHTGEDNLYAQMIDEAEGLEKIENLQSHD-NNDIYDKAVKIL 493 (531) T ss_pred HHHccC------CCHHHHHHHHHHHHHHHhhCccchhhcCCCCcHHHHHHHHHCCcHHHHHHHhcCC-CHHHHHHHHHHH Confidence 888776 36788899999999998531 11223334446788888888776 788999999999 Q NP_000290.2 709 SDMWSSKELQG 719 (747) Q Consensus 709 snL~~~~~~~~ 719 (747) .+++...+... T Consensus 494 ~~l~~~~~~~~ 504 (531) T 4TNM_A 494 ETFWTEDNEEE 504 (531) T ss_pred HHHhcCCCCcc Confidence 99987655443 No 34 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=98.21 E-value=3.4e-10 Score=119.34 Aligned_cols=366 Identities=16% Similarity=0.161 Sum_probs=222.2 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.+|..++...... ...+...++++.+...+... +..++..++.++..++....... T Consensus 71 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 150 (521) T 5TBK_C 71 TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQT 150 (521) T ss_dssp CCSSTHHHHTTSSCHHHHHHHHHHHHHHHHTTTCCCTTSCTTTTHHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHH T ss_pred hcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHH Confidence 35566677777777788888999998887643221 12233346677777777643 67788888999988876543333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... .++ T Consensus 151 ~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~ 214 (521) T 5TBK_C 151 QAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IPI 214 (521) T ss_dssp HHHHTTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHHHCHHHHHHHHHTTCHHHHHTTCCTT---------------SCH T ss_pred HHHHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCC---------------CCH Confidence 33334457777777776 5567888899999999886432 2222333 6677777766532 123 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-. .............+++..|...+.. .+..-...+..+|. T Consensus 215 ~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~ 267 (521) T 5TBK_C 215 TFLRNVTWVMVNLC---------------------RHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWALS 267 (521) T ss_dssp HHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------cCCCCCCCHHHHHHHHHHHHHHhhC------CCHHHHHHHHHHHH Confidence 33333433332211 0000001111122333333333221 11222223333333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-+ .....+.+.++++.++.++. +. T Consensus 268 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 296 (521) T 5TBK_C 268 YLTDAGN--------------------------------------------------EQIQMVIDSGIVPHLVPLLS-HQ 296 (521) T ss_dssp HHHHHCH--------------------------------------------------HHHHHHHHTTCHHHHGGGGG-CS T ss_pred HHhccCh--------------------------------------------------HHHHHHHHCChHHHHHHHhc-CC Confidence 3321100 01112234567788888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...++++ T Consensus 297 ~~~v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 371 (521) T 5TBK_C 297 EVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371 (521) T ss_dssp SHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCGGGHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTCHH T ss_pred CHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCCHHHhHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHH Confidence 677888899999998875332 2233344578888888888888889999999999998762 22 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 372 ~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 443 (521) T 5TBK_C 372 MIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 443 (521) T ss_dssp HHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHHHHGGGGSS-CHHHHHHHHHHHHHHHHHCS T ss_pred HHHHHHHh------CCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 88888776 367788999999999985322 2233344456788888888766 77888999999999887543 No 35 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=98.21 E-value=3.4e-10 Score=119.34 Aligned_cols=366 Identities=16% Similarity=0.161 Sum_probs=221.8 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.+|..++...... ...+...++++.+...+... +..++..++.++..++....... T Consensus 71 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 150 (521) T 5TBK_D 71 TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQT 150 (521) T ss_dssp -CCSHHHHHTTSSCHHHHHHHHHHHHTHHHHHHSSCSHHHHHHTHHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHH T ss_pred hcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHH Confidence 35566677777777788888999998887643221 12233346677777777643 67788888999988876543333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... .++ T Consensus 151 ~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~ 214 (521) T 5TBK_D 151 QAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IPI 214 (521) T ss_dssp HHHHTTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHHHCHHHHHHHHHTCCHHHHHTTCCTT---------------SCH T ss_pred HHHHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCC---------------CCH Confidence 33334457777777776 5567888899999999886432 2222333 6677777766532 123 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-. .............+++..|...+.. .+..-...+..+|. T Consensus 215 ~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~ 267 (521) T 5TBK_D 215 TFLRNVTWVMVNLC---------------------RHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWALS 267 (521) T ss_dssp HHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------cCCCCCCCHHHHHHHHHHHHHHhhC------CCHHHHHHHHHHHH Confidence 33333433332211 0000001111122333333333221 11222223333333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-+ .....+.+.++++.++.++. +. T Consensus 268 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 296 (521) T 5TBK_D 268 YLTDAGN--------------------------------------------------EQIQMVIDSGIVPHLVPLLS-HQ 296 (521) T ss_dssp HHHHHCH--------------------------------------------------HHHHHHHHTTCHHHHGGGGG-CS T ss_pred HHhccCh--------------------------------------------------HHHHHHHHCChHHHHHHHhc-CC Confidence 3321100 01112234567788888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...++++ T Consensus 297 ~~~v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 371 (521) T 5TBK_D 297 EVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371 (521) T ss_dssp SHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCGGGHHHHHHCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTCHH T ss_pred CHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCCHHHhHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHH Confidence 677888899999998875332 2233344578888888888888889999999999998762 22 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 372 ~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 443 (521) T 5TBK_D 372 MIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 443 (521) T ss_dssp HHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHHHHGGGGSS-CHHHHHHHHHHHHHHHHHCS T ss_pred HHHHHHHh------CCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 88888776 367788999999999985322 2233344456788888888766 77888999999999887543 No 36 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=98.14 E-value=6.4e-10 Score=126.67 Aligned_cols=381 Identities=19% Similarity=0.217 Sum_probs=223.9 Template_Neff=10.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+..++.+.+..++..++.+|.+++.........+...++++.+..++...+..++..++.+|..++......... T Consensus 234 ~~i~~L~~lL~~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~~~~L~~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 313 (780) T 2Z6G_A 234 GGIPALVNMLGSPVDSVLFHAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLI 313 (780) T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34566666776667788888999998887654333333333567777888887777888889999999888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..++.++....+..++..++.+|..++........+.. ++++.|..++... ++++. T Consensus 314 ~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~l~~L~~~l~~~----------------~~~v~ 377 (780) T 2Z6G_A 314 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLV 377 (780) T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHhCCHHHHHHHHHCCHHHHHHHHccCC----------------CHHHH Confidence 333456777777776223567788888888888765443333333 6677777666531 23343 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|+.-.. ...... ...+++..|...+.. .+..-...+..+|.++. T Consensus 378 ~~al~~L~~l~~---------------------~~~~~~---~~~~~l~~L~~~l~~------~~~~v~~~a~~~L~~l~ 427 (780) T 2Z6G_A 378 QNCLWTLRNLSD---------------------AATKQE---GMEGLLGTLVQLLGS------DDINVVTCAAGILSNLT 427 (780) T ss_pred HHHHHHHHHHhc---------------------CCCCHH---HHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 344433332110 000000 012333333333221 01111222222333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKD 562 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~ 562 (747) ... ......+...++++.|+..+.. ..++ T Consensus 428 ~~~--------------------------------------------------~~~~~~~~~~~~l~~L~~~l~~~~~~~ 457 (780) T 2Z6G_A 428 CNN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRE 457 (780) T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHhcCCCCH Confidence 110 0001112345667777776652 1456 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++..... .......+...++++.|+.++... ++.++..++.+|.+++..... ..+...++++.| T Consensus 458 ~v~~~a~~~L~~l~~~~~~--~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~l~~L 535 (780) T 2Z6G_A 458 DITEPAICALRHLTSRHQD--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRL 535 (780) T ss_pred HHHHHHHHHHHHHHcCCcc--HHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHhCChHHHH Confidence 7788899999998865321 000112223456788888888765 577889999999999876333 233455677788 Q NP_000290.2 641 TRLLTSHTGN----------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 641 l~LL~s~s~~----------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) +.++...... ...+..++..++.+|.+|+.. ......+...++++.|+.++.+. ++.++..+ T Consensus 536 ~~ll~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~aL~~L~~~-~~~~~~~~~~~~l~~L~~~l~~~-~~~v~~~a 613 (780) T 2Z6G_A 536 VQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEACTGALHILARD-IHNRIVIRGLNTIPLFVQLLYSP-IENIQRVA 613 (780) T ss_pred HHHhcCCCHHHHHHHHhhhhhhhhhcCCChHHHHHHHHHHHHHHhCC-hhHHHHHHhCCcHHHHHHHhcCC-CHHHHHHH Confidence 8777652000 000234888999999999864 44444455556788888888776 78899999 Q NP_000290.2 705 RLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 705 L~aLsnL~~~~~~~~~~~~~~ 725 (747) +.+|.+++...+....+...| T Consensus 614 ~~~L~~l~~~~~~~~~~~~~~ 634 (780) T 2Z6G_A 614 AGVLCELAQDKEAAEAIEAEG 634 (780) T ss_pred HHHHHHHhcCHHHHHHHHHCC Confidence 999999997766554444433 No 37 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=98.13 E-value=6.1e-10 Score=114.95 Aligned_cols=326 Identities=17% Similarity=0.189 Sum_probs=198.8 Template_Neff=13.100 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKE 365 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~ 365 (747) .++++.+...+.+.+..++..++.++..++.............++++.+...+....++.++..++.++..+........ T Consensus 16 ~~~i~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~ 95 (529) T 1JDH_A 16 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLL 95 (529) T ss_dssp -CHHHHHHHHHTCSCHHHHHHHHHHHHHHHTSHHHHHHHHTCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSHHHHH T ss_pred HhhHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHHhCcchHHHHHHHhhCCCCHHHHHHHHHHHHHHhcCHHHHH Confidence 45677777778777788888999999888765322211111134667777777533567788899999998876544443 Q NP_000290.2 366 ELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTM 444 (747) Q Consensus 366 ~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 444 (747) .+.. ++++.|+.++..+ ++++-..+..++..-.... +..+... T Consensus 96 ~~~~~~~~~~l~~~l~~~----------------~~~~~~~a~~~l~~l~~~~--------------------~~~~~~~ 139 (529) T 1JDH_A 96 AIFKSGGIPALVKMLGSP----------------VDSVLFYAITTLHNLLLHQ--------------------EGAKMAV 139 (529) T ss_dssp HHHHTTHHHHHHHHTTCS----------------CHHHHHHHHHHHHHHHHHC--------------------TTHHHHH T ss_pred HHHHcCCHHHHHHHhcCC----------------CHHHHHHHHHHHHHHHcCC--------------------cchHHHH Confidence 4444 6777777776532 3444444444433211100 0000100 Q NP_000290.2 445 RNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNN 524 (747) Q Consensus 445 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 524 (747) .-.++++.|...++. -+..-...+...|.++...- T Consensus 140 -~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~-------------------------------------- 174 (529) T 1JDH_A 140 -RLAGGLQKMVALLNK------TNVKFLAITTDCLQILAYGN-------------------------------------- 174 (529) T ss_dssp -HHHTHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTC-------------------------------------- T ss_pred -HHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcCC-------------------------------------- Confidence 012444544444332 12222233333333332100 Q NP_000290.2 525 NYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL 604 (747) Q Consensus 525 ~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL 604 (747) ......+.+.++++.++.++....++.++..++.+|.+++.... ....+...++++.+..++ T Consensus 175 ------------~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l 236 (529) T 1JDH_A 175 ------------QESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS------NKPAIVEAGGMQALGLHL 236 (529) T ss_dssp ------------HHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT------HHHHHHHTTHHHHHHTTT T ss_pred ------------HHHHHHHHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCc------cHHHHHHCCHHHHHHHHc Confidence 01112234566788888888742366788889999999887532 133334567888899988 Q NP_000290.2 605 QSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSM 684 (747) Q Consensus 605 ~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~gi 684 (747) .+.++.++..++++|.+++......... .++++.+..++.+ .++.++..++.+|.+++...+.....+...+. T Consensus 237 ~~~~~~~~~~~~~~l~~l~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 309 (529) T 1JDH_A 237 TDPSQRLVQNCLWTLRNLSDAATKQEGM-EGLLGTLVQLLGS------DDINVVTCAAGILSNLTCNNYKNKMMVCQVGG 309 (529) T ss_dssp TSSCHHHHHHHHHHHHHHHTTCTTCSCC-HHHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTH T ss_pred cCCCHHHHHHHHHHHHHHcchhhhHHHH-chHHHHHHHHhCC------CCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCH Confidence 8888889999999999998763221111 4566777777765 36788899999999998765555555666677 Q NP_000290.2 685 LNNIINLCRS-SASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 685 L~~Ll~LL~s-~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ++.++..+.. ..++.++..++.+|.+++..... T Consensus 310 ~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~ 343 (529) T 1JDH_A 310 IEALVRTVLRAGDREDITEPAICALRHLTSRHQE 343 (529) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHHHHHHTSSSTT T ss_pred HHHHHHHHHhcCCChHhHHHHHHHHHHHhcCccc Confidence 8888876652 12577888999999998866553 No 38 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=98.12 E-value=7.3e-10 Score=121.28 Aligned_cols=378 Identities=20% Similarity=0.248 Sum_probs=205.2 Template_Neff=11.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+...+..++..++.++..++.........+ T Consensus 99 ~i~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~ 178 (644) T 2Z6H_A 99 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLII 178 (644) T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666766777888899999998876543333333345677778888877778888899999998886444333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...+++..+...+....+..++..++.++..++........+.. ++++.|..++... ++++.. T Consensus 179 ~~~~~~~~L~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~l~~l~~~l~~~----------------~~~~~~ 242 (644) T 2Z6H_A 179 LASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLVQ 242 (644) T ss_pred HHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHccChHHHHHHHHCCHHHHHHHHhcCC----------------CHHHHH Confidence 44457777777776333567788888888888765443333333 6666676666532 111222 Q NP_000290.2 405 NATGCLRKRL-----------GMRELLALVPQ-------RATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASR 466 (747) Q Consensus 405 ~~~~~~~~~~-----------~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 466 (747) .+..+|..-. .+..++.++.. .+...-.++...+......-.-.+.++.|...+.. .. T Consensus 243 ~a~~~L~~l~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~~L~~~l~~----~~ 318 (644) T 2Z6H_A 243 NCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLR----AG 318 (644) T ss_pred HHHHHHHHHhcCCCCHHHHCchHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCHHHHHHHHHhc----CC Confidence 2222221100 01111111110 00000111111111000000112334444333221 01 Q NP_000290.2 467 CDDKSVENCMCVLHNLSYRLDAEV------------PTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEE 534 (747) Q Consensus 467 ~~~~~~~~~~~~~~~~~~~~~~~~------------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 534 (747) -+..-.+.+...|.++........ +.-.+.+... .+....+....++.+-. T Consensus 319 ~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~v~~~a~~~L~~l~---------------- 381 (644) T 2Z6H_A 319 DREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP-SHWPLIKATVGLIRNLA---------------- 381 (644) T ss_pred CCHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHCCcHHHHHHHhcCC-CCHHHHHHHHHHHHHHh---------------- Confidence 123345666777777765433210 0000000000 00000011111111111 Q NP_000290.2 535 TNPKGSGWLYHSDAIRTYLNLMGKSKK----------------------DATLEACAGALQNLTASKGLMSSGMSQLIGL 592 (747) Q Consensus 535 ~ni~~~~~lve~G~I~~LL~LL~ss~d----------------------~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli 592 (747) ........+.+.++++.|+.++.. .. ..++..++.+|.+++..... ...+. T Consensus 382 ~~~~~~~~l~~~~~~~~L~~~l~~-~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~~~------~~~~~ 454 (644) T 2Z6H_A 382 LCPANHAPLREQGAIPRLVQLLVR-AHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHN------RIVIR 454 (644) T ss_pred cCHHHHHHHHHCCcHHHHHHHHcc-CCHHHHHHHhcCCchhhhhcCCCCHHHHHHHHHHHHHHhcCcch------HHHHH Confidence 001112234566788888888863 32 23777888899988865321 22334 Q NP_000290.2 593 KEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 593 e~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..++++.|+.++.+.++.++..++.+|.+++..... ..+...++++.|..++.+ .++.++..++.+|.+++.. T Consensus 455 ~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~ 528 (644) T 2Z6H_A 455 GLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHS------RNEGVATYAAAVLFRMSED 528 (644) T ss_pred HCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhCC Confidence 457888899989888889999999999999876433 233445778888888876 3678999999999999875 Q NP_000290.2 672 QP 673 (747) Q Consensus 672 s~ 673 (747) .+ T Consensus 529 ~~ 530 (644) T 2Z6H_A 529 KP 530 (644) T ss_pred Cc Confidence 43 No 39 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=98.11 E-value=7.7e-10 Score=121.20 Aligned_cols=342 Identities=20% Similarity=0.251 Sum_probs=215.3 Template_Neff=11.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.+..++..++..|..++.........+...++++.+..++.+.++.++..++.++..++........ T Consensus 177 ~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~ 256 (671) T 6SA8_A 177 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQ 256 (671) T ss_dssp HHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHH T ss_pred HHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHH Confidence 44566677777777778888899999888765433333444456778888888877888899999999988764443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...+.++.+...+. +.++.++..++.++..++... .....+.. ++++.|+.++... +++ T Consensus 257 ~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~----------------~~~ 319 (671) T 6SA8_A 257 AVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP----------------NEQ 319 (671) T ss_dssp HHHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS----------------CHH T ss_pred HHHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcHHHHHHHHhChHHHHHHHhcCC----------------cHH Confidence 3444567778888876 566788889999999888643 22233333 6777777776531 344 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +-..+..+|..-.. ..+ ..+..+. -.++++.|+..++.. +....+.++..|.+ T Consensus 320 v~~~a~~~L~~l~~------~~~--------------~~~~~~~-~~~~l~~l~~~l~~~------~~~~~~~a~~~L~~ 372 (671) T 6SA8_A 320 ILQEALWALSNIAS------GGN--------------EQIQAVI-DAGALPALVQLLSSP------NEQILQEALWALSN 372 (671) T ss_dssp HHHHHHHHHHHHTT------SCH--------------HHHHHHH-HTTHHHHHHHHTTCS------CHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhc------CCc--------------HHHHHHH-hcChHHHHHHHhcCC------CHHHHHHHHHHHHH Confidence 44444433322110 000 0011111 123444554444321 22333344444444 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +...- ......+.+.++++.|+.++. ..+ T Consensus 373 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 401 (671) T 6SA8_A 373 IASGG--------------------------------------------------NEQIQAVIDAGALPALVQLLS-SPN 401 (671) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHGGG-CSC T ss_pred HHcCC--------------------------------------------------cHHHHHHHHcCcHHHHHHHhc-CCC Confidence 43200 001112245567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPE 639 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~ 639 (747) +.++..++.+|.+++..... ....+.+.++++.|+.++.+.++.++..++.+|.+++.... . ..+...++++. T Consensus 402 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~ 476 (671) T 6SA8_A 402 EQILQEALWALSNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPA 476 (671) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHH T ss_pred HHHHHHHHHHHHhhcCCCHH-----HHHHHHhcCcHHHHHHHcCCCCHHHHHHHHHHHHHHHcCChHHHHHHHhcCcHHH Confidence 78888999999999875332 23333456788899999988888999999999999996632 2 23345667888 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINL 691 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~L 691 (747) |..++.+ .++.++..++.+|.+|+...+.....+...+.++.++.. T Consensus 477 l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ll~~ 522 (671) T 6SA8_A 477 LVQLLSS------PNEQIQDEAEKTLLNIANGSEEQQKAVYDAGALKYLLII 522 (671) T ss_dssp HHHHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHH T ss_pred HHHHhhC------CCHHHHHHHHHHHHHHHcCCHHHHHHHhcccHHHHHHHH Confidence 8888876 367889999999999987655555555555555555544 No 40 >4RXH_B Importin subunit alpha, Large T; ARM repeat, NLS, nuclear import; 1.7553A {Neurospora crassa} Probab=98.05 E-value=1.2e-09 Score=113.39 Aligned_cols=157 Identities=18% Similarity=0.227 Sum_probs=116.8 Template_Neff=12.500 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++.++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 196 ~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 269 (495) T 4RXH_B 196 IAPALPVLAKLVY-SLDDEVLIDACWAISYLSDGSND-----KIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVT 269 (495) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred hcCHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCChHHHHHHHHhcCCccHHHHHHHHHHHHhc Confidence 3456777888887 46778888999999998864332 22333455788888888888888899999999999987 Q NP_000290.2 625 HP-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) .. .. ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 270 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~ 342 (495) T 4RXH_B 270 GDDVQTQVIINCGALPCLLSLLSS------NKDGIRKEACWTISNITAGNSAQIQSVIDANIIPPLIHLLSHA-DLKTRK 342 (495) T ss_dssp SCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHSS-CHHHHH T ss_pred CCHHHHHHHHhCCHHHHHHHHHhC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHHhcC-CHHHHH Confidence 63 22 233445677888888876 3678899999999999876554444555556788888888766 778899 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 343 ~a~~~l~~l~~~ 354 (495) T 4RXH_B 343 EACWAISNATSG 354 (495) T ss_dssp HHHHHHHHTTTT T ss_pred HHHHHHHHHHhc Confidence 999999998876 No 41 >5XJG_A Vacuolar protein 8, Nucleus-vacuole junction; Vac8p, Nvj1p, Membrane contact site; HET: B3P, PE5; 2.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.04 E-value=1.3e-09 Score=111.79 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=82.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 159 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 237 (506) T 5XJG_A 159 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 237 (506) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTCSSH-HHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHcCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 4555666666667788888899988887542 222233334567777777777777888888998888875433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 238 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 293 (506) T 5XJG_A 238 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 293 (506) T ss_dssp HHCTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSHHHHHHHHHTTHHHHHHHHHT T ss_pred hhChhHHHHHHHHcc-CCCHHHHHHHHHHHHHHhCCChhHHHHHHcCcHHHHHHHHh Confidence 11235666677775 45667788888888888765433333332 45555555554 No 42 >6KBM_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 2.902A {Saccharomyces cerevisiae} Probab=98.04 E-value=1.3e-09 Score=111.79 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=82.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 159 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 237 (506) T 6KBM_A 159 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 237 (506) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTCSSH-HHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHcCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 4555666666667788888899988887542 222233334567777777777777888888998888875433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 238 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 293 (506) T 6KBM_A 238 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 293 (506) T ss_dssp HHCTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSHHHHHHHHHTTCHHHHHHHHT T ss_pred hhChhHHHHHHHHcc-CCCHHHHHHHHHHHHHHhCCChhHHHHHHcCcHHHHHHHHh Confidence 11235666677775 45667788888888888765433333332 45555555554 No 43 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=97.99 E-value=2e-09 Score=113.28 Aligned_cols=158 Identities=18% Similarity=0.255 Sum_probs=115.7 Template_Neff=12.300 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++. T Consensus 243 ~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~ 316 (531) T 4TNM_A 243 TQPALPVLERLVQ-SMDEEVLTDACWALSYLSDNSND-----KIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVT 316 (531) T ss_pred hcchHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHH-----HHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHC Confidence 3456777777777 46777888999999998865332 22333456788889999988888899999999999987 Q NP_000290.2 625 HPLL--HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e~--~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) .... ......++++.+..++... .++.++..++.+|.+++...+.....+...++++.|+.++.+. ++.++. T Consensus 317 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 390 (531) T 4TNM_A 317 GDDLQTQMVLDQQALPCLLNLLKNN-----YKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQSA-EFEVKK 390 (531) T ss_pred CCHHHHHHHHHCCcHHHHHHHhcCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhcCC-CHHHHH Confidence 6322 2333446777888877652 2567888999999999876545555555666788888888765 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 391 ~a~~~l~~l~~~ 402 (531) T 4TNM_A 391 EAAWGISNATSG 402 (531) T ss_pred HHHHHHHHHHcC Confidence 899999888864 No 44 >6KBN_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.98 E-value=2.1e-09 Score=112.87 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=86.0 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 153 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 231 (563) T 6KBN_A 153 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 231 (563) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTTSSH-HHHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHhCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHH Confidence 4555666666667788888999998887542 222233334577777777777777888899999988876433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 232 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 287 (563) T 6KBN_A 232 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 287 (563) T ss_dssp HHCSSHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSHHHHHHHHHTTCHHHHHHHHT T ss_pred hhchhHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCChhHHHHHHHCCcHHHHHHHHh Confidence 11236667777775 55677888899999988875443333333 56677776664 No 45 >6KBN_C Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.98 E-value=2.1e-09 Score=112.87 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=86.0 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 153 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 231 (563) T 6KBN_C 153 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 231 (563) T ss_dssp CHHHHHHHTTSSSHHHHHHHHHHHHHHTSSH-HHHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHhCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHH Confidence 4555666666667788888999998887542 222233334577777777777777888899999988876433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 232 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 287 (563) T 6KBN_C 232 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 287 (563) T ss_dssp HSSTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSHHHHHHHHHTTCHHHHHHHTT T ss_pred hhchhHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCChhHHHHHHHCCcHHHHHHHHh Confidence 11236667777775 55677888899999988875443333333 56677776664 No 46 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=97.98 E-value=2.1e-09 Score=111.06 Aligned_cols=323 Identities=18% Similarity=0.194 Sum_probs=192.8 Template_Neff=13.100 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK 364 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~ 364 (747) .++++.+...+.+.++.++..++.++..+....... ..+.. .+++..+...+....++.++..++.++..++...... T Consensus 17 ~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~-~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 95 (538) T 4EV8_A 17 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASR-HAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGL 95 (538) T ss_pred cCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCChhhH-HHHHhCCChHHHHHHHhcCCCCHHHHHHHHHHHHHHcCCHHHH Confidence 356677777777777888888999998887643322 12222 2466677776653446678888999999887654433 Q NP_000290.2 365 EELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQT 443 (747) Q Consensus 365 ~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 443 (747) ..+.. ++++.|+.++..+ ++++...+..+|..-... . +..++. T Consensus 96 ~~~~~~~~~~~l~~~l~~~----------------~~~~~~~a~~~l~~l~~~------~--------------~~~~~~ 139 (538) T 4EV8_A 96 LAIFKSGGIPALVKMLGSP----------------VDSVLFYAITTLHNLLLH------Q--------------EGAKMA 139 (538) T ss_pred HHHHHCCcHHHHHHHhCCC----------------CHHHHHHHHHHHHHHhCC------C--------------HHHHHH Confidence 33333 6777777776532 344444444333221100 0 000000 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 523 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 523 (747) . .-.+++..|...++. -+..-...+...|.++... T Consensus 140 ~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~-------------------------------------- 174 (538) T 4EV8_A 140 V-RLAGGLQKMVALLNK------TNVKFLAITTDCLQILAYG-------------------------------------- 174 (538) T ss_pred H-HHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-------------------------------------- Confidence 0 012444444444332 0112222222233332210 Q NP_000290.2 524 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARL 603 (747) Q Consensus 524 ~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~L 603 (747) +......+.+.++++.|+.++....+..++..++.+|.+++..... ...+...++++.+..+ T Consensus 175 ------------~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~ 236 (538) T 4EV8_A 175 ------------NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSN------KPAIVEAGGMQALGLH 236 (538) T ss_pred ------------CHHHHHHHHHCChHHHHHHHHcCCCCHHHHHHHHHHHHHHcCCHHH------HHHHHHCCcHHHHHHH Confidence 0011112245667888888887423667788899999988865321 2333456788889999 Q NP_000290.2 604 LQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSS 683 (747) Q Consensus 604 L~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~g 683 (747) +.+.++.++..++.+|.+++......... .++++.+..++.+ .++.++..++.+|.+++...+.....+...+ T Consensus 237 l~~~~~~~~~~a~~~l~~l~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 309 (538) T 4EV8_A 237 LTDPSQRLVQNCLWTLRNLSDAATKQEGM-EGLLGTLVQLLGS------DDINVVTCAAGILSNLTCNNYKNKMMVCQVG 309 (538) T ss_pred hcCCCHHHHHHHHHHHHHHHcCCCchHHH-cCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCC Confidence 98888889999999999998763221111 3466777777765 3678888999999999765555555555666 Q NP_000290.2 684 MLNNIINLCR--SSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 684 iL~~Ll~LL~--s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .++.++..+. .. ++.++..++.+|.+++...+ T Consensus 310 ~~~~l~~~l~~~~~-~~~~~~~a~~~l~~l~~~~~ 343 (538) T 4EV8_A 310 GIEALVRTVLRAGD-REDITEPAICALRHLTSRHQ 343 (538) T ss_pred cHHHHHHHHhcCCC-CHHHHHHHHHHHHHHHcCCC Confidence 7777777665 23 56677788888888876554 No 47 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=97.98 E-value=2.2e-09 Score=108.63 Aligned_cols=158 Identities=18% Similarity=0.251 Sum_probs=116.0 Template_Neff=13.000 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 168 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 241 (454) T 4BPL_A 168 TRPALPALARLIH-SNDEEVLTDACWALSYLSDGTND-----KIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVT 241 (454) T ss_dssp HTTHHHHHHHHTT-CCCHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHhcCChH-----HHHHHHHCCcHHHHHHHhhCCChHHHHHHHHHHHHHhc Confidence 3456777777777 46777888899999998865332 22333455788888898888888899999999999987 Q NP_000290.2 625 HPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) ... . ..+...++++.+..++... .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 242 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 315 (454) T 4BPL_A 242 GDDAQTQCIIDHQALPCLLSLLTQN-----LKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTA-EFDIKK 315 (454) T ss_dssp SCHHHHHHHHTTTHHHHHHHHHHSS-----CCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHHHHS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHHHhc-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHH Confidence 632 2 2334456777888887652 2577889999999999876555555555666788888888766 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 316 ~a~~~l~~l~~~ 327 (454) T 4BPL_A 316 EAAWAISNATSG 327 (454) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHcC Confidence 899999888863 No 48 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=97.96 E-value=2.5e-09 Score=100.09 Aligned_cols=112 Identities=25% Similarity=0.272 Sum_probs=72.2 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++.........+. T Consensus 3 i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 82 (281) T 4PLS_B 3 LPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVI 82 (281) T ss_dssp HHHHHHTTTCSCHHHHHHHHHHHHHHHTCSHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHH Confidence 34556666667778888899999888765444333444455777777877777778888888888888754333222333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..++++.+...+. +.++.++..++.++..++. T Consensus 83 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 114 (281) T 4PLS_B 83 DAGALPALVQLLS-SPNEQILQEALWTLGNIAS 114 (281) T ss_dssp HTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHTT T ss_pred hCCcHHHHHHHcC-CCCHHHHHHHHHHHHHHhc Confidence 3345566666665 4455666666666666654 No 49 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=97.95 E-value=2.6e-09 Score=104.87 Aligned_cols=123 Identities=24% Similarity=0.347 Sum_probs=80.3 Template_Neff=12.500 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) ++.++..++.++.+++...+.....+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 92 ~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 171 (339) T 5Z8H_A 92 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 171 (339) T ss_pred CHHHHHHHHHHHHHHcCCCHHHHHHHHHhcChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCCHHHHHHHHHCCcHHHHH Confidence 6778888999999887644443333444 46778888888777788889999999998864 222223333456777777 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSS-TDELKEELIA--DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas-~~~~~~~Lve--giLe~Lv~LL~ 380 (747) ..+....++.++..++.++.+++. .......+.. ++++.++.++. T Consensus 172 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 219 (339) T 5Z8H_A 172 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLT 219 (339) T ss_pred HHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhcChHHHHHHHhc Confidence 777622466778888888888876 3333323322 45555555554 No 50 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=97.95 E-value=2.8e-09 Score=116.50 Aligned_cols=415 Identities=18% Similarity=0.223 Sum_probs=234.1 Template_Neff=11.700 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++..+...+. ..+..++..++.+|..++.... ....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~i~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~-~~~~~~~~~~i~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 135 (644) T 2Z6H_A 57 MVSAIVRTMQNTNDVETARCTAGTLHNLSHHRE-GLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 135 (644) T ss_pred hHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCHH-HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4455555555 4566778888888888865432 2223334567778888887777888899999999888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..+..++..++.++..++.... ....+.. ++++.|+.++... .++++ T Consensus 136 ~~~~~~~~~L~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~---------------~~~~~ 199 (644) T 2Z6H_A 136 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---------------TYEKL 199 (644) T ss_pred HHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCC---------------CCHHH Confidence 333467777877776 5567888889999999886432 2223333 6777777777642 12233 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-.. .+..+..+ ...+.++.|...+.. .+....++++..|.++ T Consensus 200 ~~~a~~~L~~l~~---------------------~~~~~~~~-~~~~~l~~l~~~l~~------~~~~~~~~a~~~L~~l 251 (644) T 2Z6H_A 200 LWTTSRVLKVLSV---------------------CSSNKPAI-VEAGGMQALGLHLTD------PSQRLVQNCLWTLRNL 251 (644) T ss_pred HHHHHHHHHHHcc---------------------ChHHHHHH-HHCCHHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 3333333321100 00000000 012334444333321 1334445566666666 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) ....... ++.-...+.. .+.-.......++.+ ....+......+.+.++++.|+..+ T Consensus 252 ~~~~~~~~~~~~~~~~l~~~l~~--~~~~v~~~a~~~L~~---------------l~~~~~~~~~~~~~~~~l~~L~~~l 314 (644) T 2Z6H_A 252 SDAATKQEGMEGLLGTLVQLLGS--DDINVVTCAAGILSN---------------LTCNNYKNKMMVCQVGGIEALVRTV 314 (644) T ss_pred hcCCCCHHHHCchHHHHHHHhcC--CCHHHHHHHHHHHHH---------------HhCCCHHHHHHHHhCCHHHHHHHHH Confidence 5432210 0000000000 000000001111111 0011112223345667888888877 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMG 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~ 633 (747) .. ..++.++..++.+|.+++..... .......+...++++.|+.++.+. +..++..++.+|.+++..... ..+.. T Consensus 315 ~~~~~~~~v~~~a~~~L~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~l~~ 392 (644) T 2Z6H_A 315 LRAGDREDITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLRE 392 (644) T ss_pred hcCCCCHHHHHHHHHHHHHHHcCCCC--HHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHH Confidence 52 14567788899999999875331 000012223457788888888765 678889999999999876433 23344 Q NP_000290.2 634 NQVFPEVTRLLTSHTGN----------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSAS 697 (747) Q Consensus 634 ~giI~~Ll~LL~s~s~~----------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d 697 (747) .++++.|+.++...... ......++..++.+|.+++... .....+...++++.|+.++.+. + T Consensus 393 ~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~-~~~~~~~~~~~i~~l~~~l~~~-~ 470 (644) T 2Z6H_A 393 QGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDV-HNRIVIRGLNTIPLFVQLLYSP-I 470 (644) T ss_pred CCcHHHHHHHHccCCHHHHHHHhcCCchhhhhcCCCCHHHHHHHHHHHHHHhcCc-chHHHHHHCCcHHHHHHHHhCC-C Confidence 56777777777652100 0002347788999999998753 3334444556788888888776 7 Q NP_000290.2 698 PKAAEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) +.++..++.+|.+++...+....+...|+ T Consensus 471 ~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 499 (644) T 2Z6H_A 471 ENIQRVAAGVLCELAQDKEAAEAIEAEGA 499 (644) T ss_pred HHHHHHHHHHHHHHhcCHHHHHHHHHCCc Confidence 88999999999999987766555544443 No 51 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=97.94 E-value=2.9e-09 Score=99.92 Aligned_cols=114 Identities=25% Similarity=0.274 Sum_probs=73.1 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (286) T 5AEI_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (286) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888999988876544333334444567777777777777888888888888875433322223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. +.++.++..++.++..++.. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 118 (286) T 5AEI_B 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASG 118 (286) T ss_dssp HHHTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HHcChHHHHHHHhh-CCCHHHHHHHHHHHHHHhCC Confidence 33345566666665 44556666677777666643 No 52 >4B8J_A IMPORTIN SUBUNIT ALPHA-1A; TRANSPORT PROTEIN, NUCLEAR LOCALIZATION SIGNAL; 2.001A {ORYZA SATIVA JAPONICA GROUP} Probab=97.93 E-value=3.2e-09 Score=111.25 Aligned_cols=160 Identities=20% Similarity=0.243 Sum_probs=114.5 Template_Neff=12.400 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.++..+....++.++..++.+|.+++..... .......++++.|..++.+.++.++..++.+|.+++ T Consensus 199 ~~~~~l~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~ 272 (528) T 4B8J_A 199 LANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQ------PSFEQTRPALPALARLIHSNDEEVLTDACWALSYLS 272 (528) T ss_dssp HHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSC------CCHHHHTTHHHHHHHHTTCCCHHHHHHHHHHHHHHT T ss_pred HHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCCC------CCHHHHhhHHHHHHHHhcCCCHHHHHHHHHHHHHHh Confidence 34556777777765334567788899999998865321 222234578888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.++.++.+ .++.++..++.+|.+++...+.....+...++++.|+.++.+..+..++ T Consensus 273 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~ 346 (528) T 4B8J_A 273 DGTNDKIQAVIEAGVCPRLVELLLH------PSPSVLIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLTQNLKKSIK 346 (528) T ss_dssp SSCHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTHHHHHHHHHHSCCCHHHH T ss_pred cCChHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHhcCCCHHHH Confidence 76 222 233445677888888776 3678889999999999875454444555556788888887654356788 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 347 ~~a~~~l~~l~~~~ 360 (528) T 4B8J_A 347 KEACWTISNITAGN 360 (528) T ss_dssp HHHHHHHHHHHTSC T ss_pred HHHHHHHHHHHcCC Confidence 89999999987543 No 53 >4R10_A Protein humpback-2, Cadherin-related hmr-1; armadillo repeat, cell adhesion, phosphorylation; HET: SEP; 2.3A {Caenorhabditis elegans} Probab=97.89 E-value=4.1e-09 Score=110.79 Aligned_cols=417 Identities=14% Similarity=0.174 Sum_probs=224.8 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.+|..+.... .....+...++++.+...+.+.++.++..++.++..++......... T Consensus 73 ~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 151 (572) T 4R10_A 73 SFVEALMAASKSSNVNVRRNAIGALSHMSEQR-GGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQ 151 (572) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTST-THHHHHHHTTTHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTHHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCC-ChHHHHHhCCcHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 44566666676677788888999998887643 22233334567777777777777888899999999887544333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++... .....+.. ++++.+..++... ..++++ T Consensus 152 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------~~~~~~ 216 (572) T 4R10_A 152 ARALNAVEALTPHLH-KTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREY--------------SDHRKL 216 (572) T ss_dssp HHHTTHHHHHGGGGG-CCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHC--------------TTCHHH T ss_pred HHHCCHHHHHHHHHh-cCCHHHHHHHHHHHHHHHCCChHHHHHHHhccHHHHHHHHHHHC--------------CCCHHH Confidence 334467777777776 556788888999999887543 22223333 6777777776521 012333 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-. ..+..+..+.. .+.++.+...+... -+..-...++.+|.++ T Consensus 217 ~~~a~~~l~~l~---------------------~~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l 269 (572) T 4R10_A 217 IYTVVRCIRSLS---------------------VCPSNKPALIS-LGCLPALYVELCTA-----KDERSQTAILVAMRNL 269 (572) T ss_dssp HHHHHHHHHHHT---------------------TSTTHHHHHHH-TTHHHHHHHHHTTC-----CSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHh---------------------cCcchHHHHHh-CCcHHHHHHHHhcC-----CCHHHHHHHHHHHHHH Confidence 333333332110 00000111110 12222222211110 1223334445555555 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) ....+.. ++.-...+. ..+.........++.+- ...+......+.+.++++.|+.++ T Consensus 270 ~~~~~~~~~~~~~~~~l~~~l~--~~~~~~~~~a~~~l~~l---------------~~~~~~~~~~~~~~~~~~~l~~~l 332 (572) T 4R10_A 270 SDSATNEENLTQLIIKLLEIIR--VANDGMTACACGTLSNL---------------TCNNTRNKQTVCSHGGIDALVTAI 332 (572) T ss_dssp GGGCTTCSCCHHHHHHHHHHHH--HCCHHHHHHHHHHHHHH---------------TSSCHHHHHHHHHTTHHHHHHHHH T ss_pred cCChHHHHHHHHHHHHHHHHhc--CCCHHHHHHHHHHHHHH---------------HcCCHHHHHHHHHCcHHHHHHHHH Confidence 4322110 000000000 00000001111111111 111112233345778888898888 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMG- 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~- 633 (747) .. ..++.++..++++|.+++..... ... ....+...++++.+..++.+.+..++..++.+|.+++..... ..+.. T Consensus 333 ~~~~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~ 410 (572) T 4R10_A 333 RRLPEVEEVTEPALCALRHCTARHSL-AEE-AQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQE 410 (572) T ss_dssp HHSTTCHHHHHHHHHHHHHHTSSSTT-HHH-HHHHHHHTTHHHHHHHHHTTCCHHHHHHHHHHHHHHHTSHHHHHHHHHC T ss_pred HhCCCcHHHHHHHHHHHHHhhccCCC-cHH-HHHHHhhCChHHHHHHHHhcCCHHHHHHHHHHHHHHhccchhHHHHHHH Confidence 62 23446888999999999432110 000 122233467888889998888888999999999999876332 22222 Q NP_000290.2 634 -----NQVFPEVTRLLTSHTG----------NTSNSEDILSSACYTVRNLMASQPQLAKQYFSS----------SMLNNI 688 (747) Q Consensus 634 -----~giI~~Ll~LL~s~s~----------~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~----------giL~~L 688 (747) .++++.+..++..... ....++.++..++.+|.+++.. +.....+... ++++.| T Consensus 411 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~l 489 (572) T 4R10_A 411 QTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANH-PAVAAACCDDIGQVGNPECPPFLDLL 489 (572) T ss_dssp CCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHHHHHHHHHHHHTTS-HHHHHHHHHCCCCTTCTTSCCHHHHH T ss_pred hhhCCCCcHHHHHHHHHHHHHhcccCcchhccCccHHHHHHHHHHHHHHHhCC-HHHHHHHhccccCCCCCCCccHHHHH Confidence 2344555555432000 0012356777888899988764 3333333332 567777 Q NP_000290.2 689 INLC------RSSASPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 689 l~LL------~s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) ..++ ... ++.++..++.+|.+++...+....+...| T Consensus 490 ~~~l~~~~~~~~~-~~~v~~~a~~~l~~l~~~~~~~~~~~~~~ 531 (572) T 4R10_A 490 HRLLAHPRLGSMD-DEVLEREILGLLYQLSKRPDGARAVESTG 531 (572) T ss_dssp HHHHHSHHHHSCS-CSHHHHHHHHHHHHHTSSHHHHHHHHTTT T ss_pred HHHHhCcccCCCC-hHHHHHHHHHHHHHHhcCCchhhHHHHcC Confidence 7777 444 77899999999999998766544443333 No 54 >5XJG_A Vacuolar protein 8, Nucleus-vacuole junction; Vac8p, Nvj1p, Membrane contact site; HET: B3P, PE5; 2.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.89 E-value=4.2e-09 Score=107.74 Aligned_cols=359 Identities=22% Similarity=0.262 Sum_probs=200.2 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....... ...++++.+...+.+.++.++..++.++..++..... .... T Consensus 39 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~-~~~~ 113 (506) T 5XJG_A 39 PLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLLI 113 (506) T ss_dssp HHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHH-HHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhchHHH----HhhccHHHHHHHhhCCCHHHHHHHHHHHHHHHcCchh-HHHH Confidence 4455555666666777777777777776532211 1234566666666666667777777777777654321 1222 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+. +.++.++..++.++..++........+.. ++++.+..++... ++++-. T Consensus 114 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 176 (506) T 5XJG_A 114 VEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQR 176 (506) T ss_dssp HHTTTHHHHHHHHT-SSCHHHHHHHHHHHHHHTTSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHHH T ss_pred HhcCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCcchhhHHHhcccHHHHHHHccCC----------------CHHHHH Confidence 23345666666665 45566777777777777654332222222 4555555555421 223322 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..- . .....+..+. ..+.++.+...++. .+..-...+...|.++.. T Consensus 177 ~a~~~l~~l---------~------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 228 (506) T 5XJG_A 177 NATGALLNM---------T------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIAV 228 (506) T ss_dssp HHHHHHHHT---------C------------SSHHHHHHHH-HHTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHH---------c------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhc Confidence 222222210 0 0000000000 02333333333221 011222223333333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) ..+ . .........++++.++.++. ..++.+ T Consensus 229 ~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~~ 258 (506) T 5XJG_A 229 DEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSRV 258 (506) T ss_dssp SHH------------------------------------------------H-HHHHHHHCTTHHHHHHHHTT-CSSHHH T ss_pred CHH------------------------------------------------H-HHHHHhhChhHHHHHHHHcc-CCCHHH Confidence 000 0 00000012346777888887 466778 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRL 643 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~L 643 (747) +..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+..+ T Consensus 259 ~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~ 332 (506) T 5XJG_A 259 KCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRL 332 (506) T ss_dssp HHHHHHHHHHHTTSHHH------HHHHHHTTHHHHHHHHHTCSSHHHHHHHHHHHHHHTTSGGGHHHHHHTTCHHHHHHG T ss_pred HHHHHHHHHHHhCCChh------HHHHHHcCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHHH Confidence 88899999998875321 22334567888888888888888999999999999876433 233445677788888 Q NP_000290.2 644 LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 644 L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +... .++.++..++++|.+++...+.....+...++++.+..++.+. ++.++..++.++..+....+ T Consensus 333 l~~~-----~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~ 399 (506) T 5XJG_A 333 LDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALADV 399 (506) T ss_dssp GGCT-----TCHHHHHHHHHHHHHTSSCCHHHHHHHHTTTHHHHHHHHTTSS-CHHHHHHHHHHHHHHTTCHH T ss_pred HcCC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChhHHHHHHHhcC-CHHHHHHHHHHHHHHhccch Confidence 7652 2467888999999999875544444555556677777777655 56677777777776665443 No 55 >6KBM_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 2.902A {Saccharomyces cerevisiae} Probab=97.89 E-value=4.2e-09 Score=107.74 Aligned_cols=359 Identities=22% Similarity=0.262 Sum_probs=200.2 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....... ...++++.+...+.+.++.++..++.++..++..... .... T Consensus 39 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~-~~~~ 113 (506) T 6KBM_A 39 PLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLLI 113 (506) T ss_dssp HHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHTTCCCHHHHHHHHHHHHHHTTSHHH-HHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhchHHH----HhhccHHHHHHHhhCCCHHHHHHHHHHHHHHHcCchh-HHHH Confidence 4455555666666777777777777776532211 1234566666666666667777777777777654321 1222 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+. +.++.++..++.++..++........+.. ++++.+..++... ++++-. T Consensus 114 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 176 (506) T 6KBM_A 114 VEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQR 176 (506) T ss_dssp HHTTTHHHHHHHHT-SCCHHHHHHHHHHHHHHTTSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHHH T ss_pred HhcCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCcchhhHHHhcccHHHHHHHccCC----------------CHHHHH Confidence 23345666666665 45566777777777777654332222222 4555555555421 223322 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..- . .....+..+. ..+.++.+...++. .+..-...+...|.++.. T Consensus 177 ~a~~~l~~l---------~------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 228 (506) T 6KBM_A 177 NATGALLNM---------T------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIAV 228 (506) T ss_dssp HHHHHHHHT---------C------------SSHHHHHHHH-HTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHH---------c------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhc Confidence 222222210 0 0000000000 02333333333221 011222223333333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) ..+ . .........++++.++.++. ..++.+ T Consensus 229 ~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~~ 258 (506) T 6KBM_A 229 DEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSRV 258 (506) T ss_dssp SHH------------------------------------------------H-HHHHHHHCTTHHHHHHHHTT-CSSHHH T ss_pred CHH------------------------------------------------H-HHHHHhhChhHHHHHHHHcc-CCCHHH Confidence 000 0 00000012346777888887 466778 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRL 643 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~L 643 (747) +..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+..+ T Consensus 259 ~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~ 332 (506) T 6KBM_A 259 KCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRL 332 (506) T ss_dssp HHHHHHHHHHHHTSHHH------HHHHHHTTCHHHHHHHHTSSCHHHHHHHHHHHHHHTTSGGGHHHHHHTTCHHHHHHH T ss_pred HHHHHHHHHHHhCCChh------HHHHHHcCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHHH Confidence 88899999998875321 22334567888888888888888999999999999876433 233445677788888 Q NP_000290.2 644 LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 644 L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +... .++.++..++++|.+++...+.....+...++++.+..++.+. ++.++..++.++..+....+ T Consensus 333 l~~~-----~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~ 399 (506) T 6KBM_A 333 LDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALADV 399 (506) T ss_dssp TTCC-----SCHHHHHHHHHHHHHHHHHCSSTHHHHHHTTHHHHHHHHSSSS-CHHHHHHHHHHHHHHTTCHH T ss_pred HcCC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChhHHHHHHHhcC-CHHHHHHHHHHHHHHhccch Confidence 7652 2467888999999999875544444555556677777777655 56677777777776665443 No 56 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=97.89 E-value=4.5e-09 Score=105.07 Aligned_cols=297 Identities=19% Similarity=0.226 Sum_probs=180.6 Template_Neff=12.000 Q NP_000290.2 236 CSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-----------NQNVQ 304 (747) Q Consensus 236 ~~~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-----------d~eVr 304 (747) |.+-++..+.........+.+.++.++..++.+|.++... ......+...++++.+..++... +..++ T Consensus 23 ~~~~~~~~~~~~~~~~~~l~~~~~~~~~~a~~~L~~l~~~-~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~ 101 (354) T 5IZA_A 23 CWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFD-EEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR 101 (354) T ss_dssp HHHHHHHCCTTCCTTTSCCCCGGGGTHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHHHHHHHHHHHHHCSCCCHHHHHHH T ss_pred HHHHHHhcCCCCCCCCCCCCCCchHhHHHHHHHHHHccCC-HHHHHHHHHcCHHHHHHHHHHhhHHHhCCCCCCCCHHHH Confidence 3343444444444445556667778888899999998765 33333344456777777777643 67788 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.++.+++.........+.. .++++.+..++. ..++.++..++.++.+++.. ......+.. ++++.|+.++. T Consensus 102 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 180 (354) T 5IZA_A 102 RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK-SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECAL 180 (354) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHH Confidence 88999999887644333333333 467777888886 55678888999999999874 222333444 77777877775 Q NP_000290.2 381 IPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 381 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 459 (747) .. .++++...+..+|.. +... +..++.+..-.|.++.|...+. T Consensus 181 ~~---------------~~~~~~~~a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (354) T 5IZA_A 181 EV---------------KKESTLKSVLSALWN---------------------LSAHCTENKADICAVDGALAFLVGTLT 224 (354) T ss_dssp HC---------------CCHHHHHHHHHHHHH---------------------HHTTCHHHHHHHHTSTTHHHHHHHHTC T ss_pred hc---------------CCHHHHHHHHHHHHH---------------------HHcCChHhHHHHHhhccHHHHHHHHHh Confidence 42 133443333333322 1111 1122222221345555555444 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) ... ...+..-.+.+..+|.+++..+. .+... T Consensus 225 ~~~--~~~~~~~~~~~~~~L~~l~~~~~-----------------------------------------------~~~~~ 255 (354) T 5IZA_A 225 YRS--QTNTLAIIESGGGILRNVSSLIA-----------------------------------------------TNEDH 255 (354) T ss_dssp SSC--SSCCHHHHHHHHHHHHHHHHHHT-----------------------------------------------TCHHH T ss_pred hcC--CCCcHHHHHHHHHHHHHHHHHhc-----------------------------------------------CCHHH Confidence 210 11113334555556666541100 01112 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) ...+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+.+.++++.|+.++.+.++.++..++.+| T Consensus 256 ~~~l~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L 329 (354) T 5IZA_A 256 RQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPK-----DQEALWDMGAVSMLKNLIHSKHKMIAMGSAAAL 329 (354) T ss_dssp HHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTHHHHHHTTTTCSSHHHHHHHHHHH T ss_pred HHHHHHCCHHHHHHHHhh-cCCHHHHHHHHHHHHHHHccCHH-----HHHHHHhCCHHHHHHHHHhccCHHHHHHHHHHH Confidence 223356678888988887 46777888999999999874332 233445678899999999888888999999999 Q NP_000290.2 620 SNMSRH 625 (747) Q Consensus 620 snLa~~ 625 (747) .+++.. T Consensus 330 ~~l~~~ 335 (354) T 5IZA_A 330 RNLMAN 335 (354) T ss_dssp HHHHHT T ss_pred HHHHcc Confidence 999876 No 57 >4R0Z_A Protein humpback-2; armadillo repeat, cell adhesion; 2.005A {Caenorhabditis elegans} Probab=97.86 E-value=5.4e-09 Score=112.30 Aligned_cols=401 Identities=14% Similarity=0.143 Sum_probs=217.2 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++.........+...++++.+..++...+..++..++.++..++.........+ T Consensus 115 ~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~ 194 (629) T 4R0Z_A 115 GLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITF 194 (629) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTHHHHHGGGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHHhCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCCHHHHHHHHHhccCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677888889999998866543333344445677888888877778888999999999875544333334 Q NP_000290.2 326 RRQNGIREAVSLLRR-TGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~s-s~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...+++..+..++.. ..+..++..++.++..++........+.. +++..++..+... .++++. T Consensus 195 ~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~~~~ 259 (629) T 4R0Z_A 195 LSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTA---------------KDERSQ 259 (629) T ss_dssp HHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHHHHHHC---------------CCHHHH T ss_pred HHccHHHHHHHHHHHcCCCHHHHHHHHHHHHHHhcCcchHHHHHHCChHHHHHHHHHhC---------------CCHHHH Confidence 444567777777651 23456777888888888765443333333 5555554444321 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-..- +..++.+ .+++..+...+.. -+......+...|.++. T Consensus 260 ~~a~~~l~~l~~~---------------------~~~~~~~---~~~i~~l~~~l~~------~~~~~~~~a~~~l~~l~ 309 (629) T 4R0Z_A 260 TAILVAMRNLSDS---------------------ATNEENL---TQLIIKLLEIIRV------ANDGMTACACGTLSNLT 309 (629) T ss_dssp HHHHHHHHHHGGG---------------------CCTTSCC---HHHHHHHHHHTTT------CCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHcCC---------------------cchHHHH---HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHH Confidence 3333333221110 0001111 1123333322211 12222333444444444 Q NP_000290.2 484 YRLDAEVP---------TRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLN 554 (747) Q Consensus 484 ~~~~~~~~---------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~ 554 (747) ..-+.... .-..-+.....+.........+..+-... ..........+.+.++++.|+. T Consensus 310 ~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~------------~~~~~~~~~~~~~~~~~~~l~~ 377 (629) T 4R0Z_A 310 CNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTAR------------HSLAEEAQSELRFCQAFPVILD 377 (629) T ss_dssp TTCHHHHHHHHHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTSS------------STTHHHHHHHHHHTTCHHHHHH T ss_pred cCCHHHHHHHHHCCHHHHHHHHHHhCCCcHHHHHHHHHHHHHhccc------------CCCcHHHHHHHhhcChHHHHHH Confidence 22111000 00000000000000000011111110000 0001111222345677888888 Q NP_000290.2 555 LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK------EKGLPQIARLLQS----------------GNSDVV 612 (747) Q Consensus 555 LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie------~giI~~Ll~LL~s----------------~d~eVr 612 (747) ++. +.++.++..++.+|.+++..... ...+.. .+.++.+..++.. .+..++ T Consensus 378 ~l~-~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 450 (629) T 4R0Z_A 378 QLE-TLRTPVIKAALGVIRNSALLQTN------LIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVI 450 (629) T ss_dssp HHT-TCCHHHHHHHHHHHHHHTTSTTH------HHHHHHCCCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHH T ss_pred HHh-cCCHHHHHHHHHHHHHHcccchh------HHHHHhccccCCccHHHHHHHHHHHHHHhcccCCCcccCCeeHHHHH Confidence 887 46778888999999998865321 111122 3456666666643 234566 Q NP_000290.2 613 RSGASLLSNMSRHPLL-HRVMGN----------QVFPEVTRLLT------SHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~-~~ll~~----------giI~~Ll~LL~------s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) ..++.+|.+++..... ..+... ++++.+..++. . .++.++..++.+|.+++.. +.. T Consensus 451 ~~~~~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~------~~~~v~~~a~~~L~~l~~~-~~~ 523 (629) T 4R0Z_A 451 EGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSM------DDEVLEREILGLLYQLSKR-PDG 523 (629) T ss_dssp HHHHHHHHHHTTSHHHHHHHHHCCCCTTCTTSCCHHHHHHHHHTCHHHHTC------SCSHHHHHHHHHHHHHTSS-HHH T ss_pred HHHHHHHHHHhCCHHHHHHHhhccccCCCCCCCcHHHHHHHHhcCcccCCC------chHHHHHHHHHHHHHHhcC-CCh Confidence 7778888888765333 222222 56777777775 3 3678889999999999854 445 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQ 718 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~~ 718 (747) ...+...++++.|..++.+. ++.++..++.+|.++..+.... T Consensus 524 ~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~L~~l~~~~~~~ 565 (629) T 4R0Z_A 524 ARAVESTGVSALLMESRGSQ-YKSVVTYANGVLSNLKRGDSAA 565 (629) T ss_dssp HHHHHTTTCHHHHHHHTTCS-SHHHHHHHHHHHHHHHHHHC-- T ss_pred HhHHhhccHHHHHHHHhccC-ChhHHHHHHHHHhhccCCChhh Confidence 55555666788888888766 7888999999999988766553 No 58 >4R0Z_A Protein humpback-2; armadillo repeat, cell adhesion; 2.005A {Caenorhabditis elegans} Probab=97.85 E-value=5.5e-09 Score=112.24 Aligned_cols=418 Identities=14% Similarity=0.170 Sum_probs=229.8 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.+|..+.... .....+...++++.+...+.+.+..++..++.++.+++......... T Consensus 73 ~~~~~L~~~l~~~~~~~~~~a~~~L~~l~~~~-~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 151 (629) T 4R0Z_A 73 SFVEALMAASKSSNVNVRRNAIGALSHMSEQR-GGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQ 151 (629) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTST-THHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTTHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCC-CchHHHHhCCcHHHHHHHHhCCCHHHHHHHHHHHHHHHcCChHHHHH Confidence 45566666676677888889999999887643 22233334467777888887777788889999999887544333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+..++. ..++.++..++.++.+++... .....+.. ++++.|+.++... ..++++ T Consensus 152 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------~~~~~~ 216 (629) T 4R0Z_A 152 ARALNAVEALTPHLH-KTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREY--------------SDHRKL 216 (629) T ss_dssp HHHTTHHHHHGGGGG-CCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHC--------------TTCHHH T ss_pred HHHCCHHHHHHHHHh-ccCHHHHHHHHHHHHHHhCCCHHHHHHHHHccHHHHHHHHHHHc--------------CCCHHH Confidence 444467777888776 556788889999999987543 22333333 6777777777621 012233 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-.. .+..+..+.. .+.+..++..+... .+..-...++..|.++ T Consensus 217 ~~~a~~~l~~l~~---------------------~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l 269 (629) T 4R0Z_A 217 IYTVVRCIRSLSV---------------------CPSNKPALIS-LGCLPALYVELCTA-----KDERSQTAILVAMRNL 269 (629) T ss_dssp HHHHHHHHHHHTT---------------------STTHHHHHHH-TTHHHHHHHHHHHC-----CCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhc---------------------CcchHHHHHH-CChHHHHHHHHHhC-----CCHHHHHHHHHHHHHH Confidence 3333333322110 0001111111 12222222111110 1122334445555555 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) +..-+.. ++.-...+.. .+.........++.+ ....+......+.+.++++.|+.++ T Consensus 270 ~~~~~~~~~~~~~i~~l~~~l~~--~~~~~~~~a~~~l~~---------------l~~~~~~~~~~~~~~~~~~~l~~~l 332 (629) T 4R0Z_A 270 SDSATNEENLTQLIIKLLEIIRV--ANDGMTACACGTLSN---------------LTCNNTRNKQTVCSHGGIDALVTAI 332 (629) T ss_dssp GGGCCTTSCCHHHHHHHHHHTTT--CCHHHHHHHHHHHHH---------------HHTTCHHHHHHHHHTTHHHHHHHHH T ss_pred cCCcchHHHHHHHHHHHHHHHhc--CCHHHHHHHHHHHHH---------------HHcCCHHHHHHHHHCCHHHHHHHHH Confidence 4322110 0000000000 000000011111111 1111112233346778888888888 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMG- 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~- 633 (747) .. ..+..++..++.+|.+++..... ... ....+...++++.|+.++.+.++.++..++.+|.+++..... ..+.. T Consensus 333 ~~~~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~ 410 (629) T 4R0Z_A 333 RRLPEVEEVTEPALCALRHCTARHSL-AEE-AQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQE 410 (629) T ss_dssp HHCTTCHHHHHHHHHHHHHHTSSSTT-HHH-HHHHHHHTTCHHHHHHHHTTCCHHHHHHHHHHHHHHTTSTTHHHHHHHC T ss_pred HhCCCcHHHHHHHHHHHHHhcccCCC-cHH-HHHHHhhcChHHHHHHHHhcCCHHHHHHHHHHHHHHcccchhHHHHHhc Confidence 62 13446888999999999432110 000 123334567788899999888888999999999999876322 22211 Q NP_000290.2 634 -----NQVFPEVTRLLTSHTG----------NTSNSEDILSSACYTVRNLMASQPQLAKQYFSS----------SMLNNI 688 (747) Q Consensus 634 -----~giI~~Ll~LL~s~s~----------~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~----------giL~~L 688 (747) .++++.++.++..... ....+..++..++.+|.+++.. +.....+.+. ++++.| T Consensus 411 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~L~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~l 489 (629) T 4R0Z_A 411 QTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANH-PAVAAACCDDIGQVGNPECPPFLDLL 489 (629) T ss_dssp CCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHHHHHHHHHHHHTTS-HHHHHHHHHCCCCTTCTTSCCHHHHH T ss_pred cccCCccHHHHHHHHHHHHHHhcccCCCcccCCeeHHHHHHHHHHHHHHHhCC-HHHHHHHhhccccCCCCCCCcHHHHH Confidence 3455566666532000 0002345667788888888764 4444444443 567777 Q NP_000290.2 689 INLCR------SSASPKAAEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 689 l~LL~------s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) ..++. +. ++.++..++.+|.+++...+....+...|. T Consensus 490 ~~~l~~~~~~~~~-~~~v~~~a~~~L~~l~~~~~~~~~l~~~~~ 532 (629) T 4R0Z_A 490 HRLLAHPRLGSMD-DEVLEREILGLLYQLSKRPDGARAVESTGV 532 (629) T ss_dssp HHHHTCHHHHTCS-CSHHHHHHHHHHHHHTSSHHHHHHHHTTTC T ss_pred HHHhcCcccCCCc-hHHHHHHHHHHHHHHhcCCChHhHHhhccH Confidence 77776 44 778899999999999977766555554444 No 59 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=97.84 E-value=6.1e-09 Score=106.37 Aligned_cols=350 Identities=19% Similarity=0.201 Sum_probs=191.7 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+..++.+.++.++..++.++.+++.........+...++++.++.++. ..+..++..++.+|.+++... .... T Consensus 44 ~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~-~~~~ 122 (457) T 1XM9_A 44 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKE 122 (457) T ss_dssp THHHHHHHHTTSSCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSS-STHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHHHhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCH-HHHH Confidence 34566677777777888999999999988654443444445567778888876 556778888999999887632 2222 Q NP_000290.2 324 ETRRQNGIREAVSLL----------------RRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSG 385 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL----------------~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~ 385 (747) .+. .++++.+..++ . ..++.++..++.++.+++........+.. ++++.|+.++...... T Consensus 123 ~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~ 200 (457) T 1XM9_A 123 ELI-ADALPVLADRVIIPFSGWCDGNSNMSRE-VVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAA 200 (457) T ss_dssp HHH-HHHHHHCCCCCCHHHHTCC----------CCCHHHHHHHHHHHHHHTTSHHHHHHHTTSTTHHHHHHHHHHHHHHH T ss_pred HHH-cchHHHHHHHhccccCCCCCCCCCcccc-cCCHHHHHHHHHHHHHHccChHHHHHHHhcccHHHHHHHHHHHhhhc Confidence 222 45677777776 3 44667888899999999876544444443 5677777777642211 Q NP_000290.2 386 WCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLA-------LVPQR-ATSSRVNLSSAD------------------- 438 (747) Q Consensus 386 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~-~~~~~~~~~~~~------------------- 438 (747) ...++++...+..+|..-....+... ..+.+ ...+.......+ T Consensus 201 ----------~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 270 (457) T 1XM9_A 201 ----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEE 270 (457) T ss_dssp ----------TCTTCTTHHHHHHHHHHHTTTHHHHSCCHHHHHHHTC----------------------------CCCCC T ss_pred ----------CcCCHHHHHHHHHHHHHHhcccccCCCcchhhhhhcccccccccccccccCcccchhccccccCCCCccc Confidence 11234444455544433211000000 00000 000000000000 Q NP_000290.2 439 ---AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFS 515 (747) Q Consensus 439 ---~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 515 (747) .+++.+.. .+.+..|...+... -+....+.+...|.|+...- T Consensus 271 ~~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~L~~l~~~~----------------------------- 315 (457) T 1XM9_A 271 TNPKGSGWLYH-SDAIRTYLNLMGKS-----KKDATLEACAGALQNLTASK----------------------------- 315 (457) T ss_dssp SSCCGGGGGGS-HHHHHHHHHHHHHC-----CCHHHHHHHHHHHHHHTTCS----------------------------- T ss_pred CCCchhHHhhc-hhHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhcc----------------------------- Confidence 00000000 01111111111000 00000011111111111000 Q NP_000290.2 516 NKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK 595 (747) Q Consensus 516 ~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g 595 (747) +.... ......+.+.++++.|+.++. +.++.++..++.+|.+++.... ....+ ..+ T Consensus 316 ---------------~~~~~-~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~------~~~~~-~~~ 371 (457) T 1XM9_A 316 ---------------GLMSS-GMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHPL------LHRVM-GNQ 371 (457) T ss_dssp ---------------SSHHH-HHHHCCCCCSCCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSGG------GHHHH-HHH T ss_pred ---------------ccccC-CcchhhhhhcchHHHHHHHHh-cCCHHHHHHHHHHHHHHhcCHH------HHHHH-Hcc Confidence 00000 001123456778899999998 4677888999999999986432 12232 345 Q NP_000290.2 596 GLPQIARLLQSG------NSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRN 667 (747) Q Consensus 596 iI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsn 667 (747) +++.|+.++... ++.++..++.+|.+|+.. +.. ..+...++++.|..++... .++.++..++.+|.+ T Consensus 372 ~~~~l~~~l~~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~ll~~~-----~~~~v~~~a~~~L~~ 446 (457) T 1XM9_A 372 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS-----ASPKAAEAARLLLSD 446 (457) T ss_dssp THHHHHHTTTSCCSCSTTHHHHHHHHHHHHHHHHTTCTHHHHHHCCHHHHHHHHHHHHCT-----TCHHHHHHHHHHHHT T ss_pred cHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhcCHHHHHHHHhccHHHHHHHHHhCC-----CCHHHHHHHHHHHHH Confidence 788888888765 678899999999999854 333 3445567788888887652 267888999999999 Q NP_000290.2 668 LMAS 671 (747) Q Consensus 668 La~~ 671 (747) |+.. T Consensus 447 l~~~ 450 (457) T 1XM9_A 447 MWSS 450 (457) T ss_dssp TSSS T ss_pred Hhhc Confidence 8864 No 60 >4I2Z_A Protein UNC-45, Heat shock protein; chaperone, myosin folding, protein filaments; 2.9A {Caenorhabditis elegans} Probab=97.84 E-value=7.3e-09 Score=122.51 Aligned_cols=69 Identities=14% Similarity=0.132 Sum_probs=41.5 Template_Neff=8.600 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) ++.|+.++...+..++..+..++..+... ......+...+.++.|+.++.+.++..+..++.+|..++. T Consensus 648 ~~~Lv~ll~~~s~~~r~~~~~~l~~l~~~-~~~R~~iv~~G~v~~Ll~ll~~~~~~~~~~Aa~ALa~l~~ 716 (961) T 4I2Z_A 648 VPACVAVSKTESKNALELIARSLLAFAEY-EDLRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA 716 (961) T ss_dssp HHHHHHTCCCSCSHHHHHHHHHHHTTSCS-STTHHHHTTTTHHHHHHHHHHHSCTHHHHHHHHHHHHHSS T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHhCC-HHHHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc Confidence 44555555555566677777777777643 3344445555666777777665555566666666665543 No 61 >6SWY_5 Vacuolar import and degradation protein; Suppressed, Suppreseed, LIGASE; 3.2A { Saccharomyces cerevisiae YJM1133} Probab=97.83 E-value=7.4e-09 Score=121.91 Aligned_cols=402 Identities=11% Similarity=0.070 Sum_probs=223.3 Template_Neff=8.700 Q NP_000290.2 240 IECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFR 317 (747) Q Consensus 240 ~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~ 317 (747) +...+.++..+..++...+..++..++.+|..++..... ....+...++++.++.++...+ +. +..++.+|..++.. T Consensus 281 l~~~~~~~~~L~~Ll~s~~~~lr~~Al~~L~~L~~~~~~~~~~~~~~~g~l~~Li~lL~~~~~~~-~~~al~~L~~L~~~ 359 (921) T 6SWY_5 281 LRNDATFKMFVLGLLKSNDVNIRCVALKFLLQPYFTEDKKWEDTRTLEKILPYLVKSFNYDPLPW-WFDPFDMLDSLIVL 359 (921) T ss_dssp STTCSHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHSSSTTSCHHHHHHHHHHHHHTTSCSSCCT-TCCHHHHHHHHHHH T ss_pred hhcccchHHHHHHHhcCCCHHHHHHHHHHHHHHHhCCCCchhhHHHHccHHHHHHHHcCCCCCch-hchHHHHHHHHHHH Confidence 334455566666777777788899999999998865332 1233344567888888887654 44 77888888888762 Q NP_000290.2 318 S-------TTNKLETRRQNGIRE-AVSLLRRTG--------NAEIQKQLTGLLWNLSSTDEL-KEELIA--DALPVLADR 378 (747) Q Consensus 318 ~-------~~~~~~ll~~~IL~~-Ll~lL~ss~--------d~eVr~~AL~aLsnLas~~~~-~~~Lve--giLe~Lv~L 378 (747) . ......+...+.+.. +..++. .. +..++..++.++..++..... ...+.. ++++.|+.+ T Consensus 360 ~~~~~~~~~~~~~~l~~~g~i~~lL~~ll~-~~~~~~~~~~~~~v~~~al~~L~~L~~~~e~~r~~l~~~~~~l~~L~~l 438 (921) T 6SWY_5 360 YNEITPMNNPVLTTLAHTNVIFCILSRFAQ-CLSLPQHNEATLKTTTKFIKICASFAASDEKYRLLLLNDTLLLNHLEYG 438 (921) T ss_dssp HHHHSTTCCHHHHHHHHTTHHHHHHHHHHH-HHTCSSCCHHHHHHHHHHHHHHHHHHTSCHHHHHHHHTTSSHHHHHHHH T ss_pred hcccCCCCCHHHHHHHHcChHHHHHHHHHH-hcCCccCCcCCHHHHHHHHHHHHHHhCCCHHHHHHHhccccHHHHHHHH Confidence 1 111122223455565 555554 33 566778888999888875432 232333 567777777 Q NP_000290.2 379 VIIPF-------SGWC------DGNSNMS-REVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAG-RQT 443 (747) Q Consensus 379 L~~~~-------~~~~------~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~ 443 (747) +.... +.|- .+....+ ....|+++...+..+|+. ++..... ++. T Consensus 439 L~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~d~~v~~~al~~L~~---------------------Ls~~~~~lr~~ 497 (921) T 6SWY_5 439 LESHITLIQDFISLKDEIKETTTESHSMCLPPIYDHDFVAAWLLLLKS---------------------FSRSVSALRTT 497 (921) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTTTCTTCCCCCTTHHHHHHHHHHHHH---------------------HTTCHHCCCCC T ss_pred HHhhHHHHHHHHhccHHHHhcccccccCCCCCCCCHHHHHHHHHHHHH---------------------HhCCHHHHHHH Confidence 76220 0000 0000000 011124444444444432 1111111 111 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVA-ASRC----------DDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTG 512 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~-~~~~----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 512 (747) +.. .|++..|...++.... ...| +..-...+...|.|++..- T Consensus 498 l~~-~g~i~~Ll~lL~~~~~~~~~~~~~~~~~~~~~~~v~~~al~aL~nL~~~~-------------------------- 550 (921) T 6SWY_5 498 LKR-NKIAQLLLQILSKTYTLTKECYFAGQDFMKPEIMIMGITLGSICNFVVEF-------------------------- 550 (921) T ss_dssp SCC-HHHHHHHHHHHHHHHHHHHHCGGGCSTTTHHHHHHHHHHHHHHHHHTSSS-------------------------- T ss_pred HHH-CChHHHHHHHHHhhccchHhhhcCCcccccccHHHHHHHHHHHHHHHccC-------------------------- Confidence 111 2444444444432200 0000 1111122222222222110 Q NP_000290.2 513 CFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS----------------------KKDATLEACAG 570 (747) Q Consensus 513 ~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss----------------------~d~eVr~~AL~ 570 (747) ......+++.|+++.|+.++... .+..++..+++ T Consensus 551 ------------------------~~~~~~l~~~gii~~L~~lL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~al~ 606 (921) T 6SWY_5 551 ------------------------SNLQSFMLRNGIIDIIEKMLTDPLFNSKKAWDDNEDERRIALQGIPVHEVKANSLW 606 (921) T ss_dssp ------------------------CTTHHHHHHTTHHHHHHHHHTSTTTCTTSCCCSSCHHHHHHSTTSCCSHHHHHHHH T ss_pred ------------------------chHHHHHHHCCHHHHHHHHhcChhhccccccCCCccHHHHHhcCCCCHHHHHHHHH Confidence 01112234556677777766521 45677889999 Q NP_000290.2 571 ALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-----------L-HRVMG----- 633 (747) Q Consensus 571 aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-----------~-~~ll~----- 633 (747) +|.+++..... . ....+...++++.|+.++.+.++.++..++++|.+++.... . ...+. T Consensus 607 aL~nL~~~~~~---~-~~~~l~~~~~l~~Ll~lL~~~~~~v~~~a~~~L~nL~~~~~~~~~~ll~~~~~~~~l~~~~~~~ 682 (921) T 6SWY_5 607 VLRHLMYNCQN---E-EKFQLLAKIPMNLILDFINDPCWAVQAQCFQLLRNLTCNSRKIVNILLEKFKDVEYKIDPQTGN 682 (921) T ss_dssp HHHHHTTTCCH---H-HHHHHHHHSCHHHHHTTTTCSSHHHHHHHHHHHHHHHTTCSHHHHHHHHTC------------- T ss_pred HHHHHHcCCCH---H-HHHHHHhcCCHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhhcccceeeCcCCCC Confidence 99999875331 0 12344566888999999988888999999999999987632 1 12222 Q NP_000290.2 634 ------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS-SMLNNIINLCR---------SSAS 697 (747) Q Consensus 634 ------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~-giL~~Ll~LL~---------s~~d 697 (747) .++++.|+..+.........+..++..++++|.+++...+.....+++. ++++.|..++. .. + T Consensus 683 ~~~~~~~~ll~~L~~~L~~~~~~~~~~~~v~~~al~~L~nLa~~~~~~~~~ii~~~~il~~L~~lL~~~~~~~~~~~~-~ 761 (921) T 6SWY_5 683 KISIGSTYLFEFLAKKMRLLNPLDTQQKKAMEGILYIIVNLAAVNENKKQLVIEQDEILNIMSEILVETTTDSSSYGN-D 761 (921) T ss_dssp ------CCHHHHHHHHHHHSCTTSHHHHHHHHHHHHHHHHHHTSCHHHHHHHHHCHHHHHHHHHHHTCCSSCCSSGGG-C T ss_pred ccccccccHHHHHHHHHhccCCCchhcHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHHhcCCCccccCC-C Confidence 3567777777765200000156788999999999997654544444544 67888888887 44 6 Q NP_000290.2 698 PKAAEAARLLLSDMWSSKELQGV 720 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~~~~~~~~ 720 (747) +.++..++++|.+|+...+.+.. T Consensus 762 ~~v~~~al~aL~nL~~~~~~~~~ 784 (921) T 6SWY_5 762 SNLKLACLWVLNNLLWNSSVSHY 784 (921) T ss_dssp HHHHHHHHHHHHHHHCC------ T ss_pred HHHHHHHHHHHHHHHcCCCcccc Confidence 78999999999999987655433 No 62 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=97.83 E-value=6.6e-09 Score=103.80 Aligned_cols=297 Identities=19% Similarity=0.226 Sum_probs=179.9 Template_Neff=12.000 Q NP_000290.2 236 CSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-----------NQNVQ 304 (747) Q Consensus 236 ~~~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-----------d~eVr 304 (747) |.+-++-.+.........+.+.++.++..++.+|.++... ......+...++++.+..++... +..++ T Consensus 23 ~~~~~~~~~~~~~~~~~~l~~~~~~~~~~a~~~L~~l~~~-~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~ 101 (354) T 5IZ8_A 23 CWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFD-EEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR 101 (354) T ss_dssp HHHHHHHSCSSCCCCSSCCCCGGGGTHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHHHHHHHHHHHHHCSCCCHHHHHHH T ss_pred HHHHHHhcCCCCCCCCCCCCCCchHhHHHHHHHHHHccCC-HHHHHHHHHcCHHHHHHHHHHhhHHHhCCCCCCCCHHHH Confidence 4443343344444444555667778888899999988765 33333344456777777777643 67788 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.++.+++.........+.. .++++.+..++. ..++.++..++.++.+++.. ......+.. ++++.|+.++. T Consensus 102 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 180 (354) T 5IZ8_A 102 RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK-SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECAL 180 (354) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGG-SSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHH Confidence 88999999987644333333333 467777888886 55678888999999999874 222333444 77777877776 Q NP_000290.2 381 IPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 381 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 459 (747) .. .++++...+..+|.. +... +..++.+..-.|.++.|...+. T Consensus 181 ~~---------------~~~~~~~~a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (354) T 5IZ8_A 181 EV---------------KKESTLKSVLSALWN---------------------LSAHCTENKADICAVDGALAFLVGTLT 224 (354) T ss_dssp HC---------------CSHHHHHHHHHHHHH---------------------HHTSCHHHHHHHHTSTTHHHHHHHHTT T ss_pred hc---------------CCHHHHHHHHHHHHH---------------------HHcCChHhHHHHHhhccHHHHHHHHHh Confidence 42 133443333333322 1111 1122222221345555555444 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) ... ...+..-.+.+..+|.+++..+. .+... T Consensus 225 ~~~--~~~~~~~~~~~~~~L~~l~~~~~-----------------------------------------------~~~~~ 255 (354) T 5IZ8_A 225 YRS--QTNTLAIIESGGGILRNVSSLIA-----------------------------------------------TNEDH 255 (354) T ss_dssp CCC--TTSCCHHHHHHHHHHHHHHHHHH-----------------------------------------------TCHHH T ss_pred hcC--CCCcHHHHHHHHHHHHHHHHHhc-----------------------------------------------CCHHH Confidence 210 01113334555555666541100 01112 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) ...+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+.+.++++.|+.++.+.++.++..++.+| T Consensus 256 ~~~l~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L 329 (354) T 5IZ8_A 256 RQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPK-----DQEALWDMGAVSMLKNLIHSKHKMIAMGSAAAL 329 (354) T ss_dssp HHHHHTTTHHHHHHHTTT-CSCHHHHHHHHHHHHHHSSSCHH-----HHHHHHTTTHHHHHHHHSSCSSHHHHHHHHHHH T ss_pred HHHHHHCCHHHHHHHHhh-cCCHHHHHHHHHHHHHHHccCHH-----HHHHHHhCCHHHHHHHHHhccCHHHHHHHHHHH Confidence 223356678888888887 46777888999999999874332 233445678899999999888888999999999 Q NP_000290.2 620 SNMSRH 625 (747) Q Consensus 620 snLa~~ 625 (747) .+++.. T Consensus 330 ~~l~~~ 335 (354) T 5IZ8_A 330 RNLMAN 335 (354) T ss_dssp HHHHTT T ss_pred HHHHcc Confidence 999876 No 63 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=97.83 E-value=6.4e-09 Score=107.67 Aligned_cols=374 Identities=16% Similarity=0.150 Sum_probs=218.5 Template_Neff=13.100 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..+++.+...+.+.++.++..++.++..+..............++++.+...+. ..++.++..++.++..+..... .. T Consensus 18 ~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~-~~ 96 (553) T 3IFQ_A 18 TRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHRE-GL 96 (553) T ss_dssp HHTHHHHHHHHTCSCHHHHHHHHHHHHHHTTSHHHHHHHHTCHHHHHHHHHHHTTCCCHHHHHHHHHHHHHHTTSHH-HH T ss_pred cCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHhcCchHHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHH-HH Confidence 345666777777777888888999998887653221111112356666777666 4556778888888888775432 22 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...+.++.+...+. +.++.++..++.++..++..... ...+.. ++++.|..++... ++ T Consensus 97 ~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~ 159 (553) T 3IFQ_A 97 LAIFKSGGIPALVRMLS-SPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN----------------NP 159 (553) T ss_dssp HHHHHTTHHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTGGGGTGGGGGSS----------------CH T ss_pred HHHHHcCcHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCChHHHHHHHhcCHHHHHHHHHhcC----------------CH Confidence 22333456777777776 55677888888888888764332 222222 6666676666531 33 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-... .+ ..+..+ --.++++.|...+... .+......++..|. T Consensus 160 ~~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~ 213 (553) T 3IFQ_A 160 KFLAITTDCLQLLAYG------NQ--------------ESKLII-LANGGPQALVQIMRNY-----SYEKLLWTTSRVLK 213 (553) T ss_dssp HHHHHHHHHHHHHHTT------CH--------------HHHHHH-HHTTHHHHHHHHHHHC-----CCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHcC------CH--------------HHHHHH-HHCCHHHHHHHHHhcC-----CcHHHHHHHHHHHH Confidence 4444444433321100 00 000000 0113344443333210 01111222223333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) +++..- .....+.+.++++.++.++. +. T Consensus 214 ~l~~~~---------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 241 (553) T 3IFQ_A 214 VLSVCP---------------------------------------------------SNKPAIVEAGGMQALGKHLT-SN 241 (553) T ss_dssp HHTTST---------------------------------------------------THHHHHHHTTHHHHHHGGGG-SS T ss_pred HHhCCc---------------------------------------------------chHHHHHHCchHHHHHHHHh-cC Confidence 322100 00112234567888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++..... ... ..++++.+..++.+.++.++..++.+|.+++... .. ..+...++++ T Consensus 242 ~~~~~~~a~~~l~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 313 (553) T 3IFQ_A 242 SPRLVQNCLWTLRNLSDVATK------QEG--LESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVE 313 (553) T ss_dssp CHHHHHHHHHHHHHHHTTCTT------CSC--CHHHHHHHHTTTTCCCHHHHHHHHHHHHHHTTTCHHHHHHHTTTTHHH T ss_pred CHHHHHHHHHHHHHhCChhHH------HHH--HHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHccHHH Confidence 778888999999999865321 111 2467888888888888889999999999998763 22 2334455777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ---LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e---~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+... ..++.++..++.+|.+++...+. ....+...+.++.+..++.+..++.++..++.+|.+++... T Consensus 314 ~l~~~l~~~----~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~ 389 (553) T 3IFQ_A 314 ALIHAILRA----GDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCP 389 (553) T ss_dssp HHHHHHHHH----TTCHHHHHHHHHHHHHHTSSSTTHHHHHHHHHTTTHHHHHHHGGGCTTCHHHHHHHHHHHHHHTTSG T ss_pred HHHHHHHHc----CCChHhHHHHHHHHHHHhcCCChHHHHHHHHHHcchHHHHHHHHcCCCChHHHHHHHHHHHHHhcCc Confidence 777766531 02567888999999999875332 11223344567888888876523788899999999998876 Q NP_000290.2 716 ELQGVLRQQG 725 (747) Q Consensus 716 ~~~~~~~~~~ 725 (747) +....+...| T Consensus 390 ~~~~~~~~~~ 399 (553) T 3IFQ_A 390 ANHAPLQEAA 399 (553) T ss_dssp GGHHHHHHTT T ss_pred ccHHHHHHcc Confidence 6554444333 No 64 >4I2W_A Protein UNC-45, Heat shock 70; chaperone, myosin folding, protein filaments; 3.6A {Caenorhabditis elegans} Probab=97.83 E-value=7.9e-09 Score=122.23 Aligned_cols=70 Identities=14% Similarity=0.133 Sum_probs=42.2 Template_Neff=8.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +++.|+.++...+..++..+..++..+... ......+...+.++.|+.++.+.++..+..++.+|..++. T Consensus 647 ~~~~Lv~ll~~~s~~~r~~~~~~l~~l~~~-~~~R~~ivq~g~~~~Ll~ll~~~~~~~~~~Aa~ALa~l~~ 716 (961) T 4I2W_A 647 AVPACVAVSKTESKNALELIARSLLAFAEY-EDLRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA 716 (961) T ss_dssp SSHHHHHTTCCCCSHHHHHHHHHHHTTSSS-STTTTTTTTSSHHHHHHHHHHHSTTHHHHHHHHHHHTTSS T ss_pred CHHHHHHHhcCCCHHHHHHHHHHHHHHhCC-HHHHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc Confidence 344555555555566677777777777643 3344445555666777776665555566666666666653 No 65 >4R10_A Protein humpback-2, Cadherin-related hmr-1; armadillo repeat, cell adhesion, phosphorylation; HET: SEP; 2.3A {Caenorhabditis elegans} Probab=97.79 E-value=8.7e-09 Score=108.23 Aligned_cols=398 Identities=14% Similarity=0.146 Sum_probs=205.5 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+...++.++..++.++..++.........+ T Consensus 115 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 194 (572) T 4R10_A 115 GLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITF 194 (572) T ss_dssp THHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTHHHHHHHHTTHHHHHGGGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHCCChHHHHHH Confidence 34555666666677888889999998866443333334444677778888877778888899999988875443333333 Q NP_000290.2 326 RRQNGIREAVSLLRR-TGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~s-s~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...+++..+...+.. ..+..++..++.++..++........+.. ++++.++..+... .++++. T Consensus 195 ~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~~~~ 259 (572) T 4R10_A 195 LSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTA---------------KDERSQ 259 (572) T ss_dssp HHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHHHHTTC---------------CSHHHH T ss_pred HhccHHHHHHHHHHHCCCCHHHHHHHHHHHHHHhcCcchHHHHHhCCcHHHHHHHHhcC---------------CCHHHH Confidence 344566667766641 23456778888888888765443333333 5555554433321 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ....++.+ .+++..+...++. -+..-...+...|.++. T Consensus 260 ~~a~~~l~~l~~---------------------~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 309 (572) T 4R10_A 260 TAILVAMRNLSD---------------------SATNEENL---TQLIIKLLEIIRV------ANDGMTACACGTLSNLT 309 (572) T ss_dssp HHHHHHHHHHGG---------------------GCTTCSCC---HHHHHHHHHHHHH------CCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHcC---------------------ChHHHHHH---HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 333333322110 00011111 1123333322211 12222333444444444 Q NP_000290.2 484 YRLDAEVP---------TRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLN 554 (747) Q Consensus 484 ~~~~~~~~---------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~ 554 (747) ..-+.... .-...+.....+.........+..+-.. . ...+......+...++++.++. T Consensus 310 ~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~----~--------~~~~~~~~~~~~~~~~~~~l~~ 377 (572) T 4R10_A 310 CNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTA----R--------HSLAEEAQSELRFCQAFPVILD 377 (572) T ss_dssp SSCHHHHHHHHHTTHHHHHHHHHHHSTTCHHHHHHHHHHHHHHTS----S--------STTHHHHHHHHHHTTHHHHHHH T ss_pred cCCHHHHHHHHHCcHHHHHHHHHHhCCCcHHHHHHHHHHHHHhhc----c--------CCCcHHHHHHHhhCChHHHHHH Confidence 32111000 0000000000000000000000000000 0 0000111122245567788888 Q NP_000290.2 555 LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK------EKGLPQIARLLQS----------------GNSDVV 612 (747) Q Consensus 555 LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie------~giI~~Ll~LL~s----------------~d~eVr 612 (747) ++. +.+..++..++.+|.+++..... ...+.+ .++++.+..++.. .++.++ T Consensus 378 ~l~-~~~~~v~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 450 (572) T 4R10_A 378 QLE-TLRTPVIKAALGVIRNSALLQTN------LIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVI 450 (572) T ss_dssp HHT-TCCHHHHHHHHHHHHHHHTSHHH------HHHHHHCCCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHH T ss_pred HHh-cCCHHHHHHHHHHHHHHhccchh------HHHHHHHhhhCCCCcHHHHHHHHHHHHHhcccCcchhccCccHHHHH Confidence 887 36667777888888888764221 111122 2344555555432 234566 Q NP_000290.2 613 RSGASLLSNMSRHPLLH-RVMGN----------QVFPEVTRLL------TSHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~-~ll~~----------giI~~Ll~LL------~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) ..++.+|.+++...... .+... ++++.+..++ .. .++.++..++.+|.+++.. +.. T Consensus 451 ~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~------~~~~v~~~a~~~l~~l~~~-~~~ 523 (572) T 4R10_A 451 EGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSM------DDEVLEREILGLLYQLSKR-PDG 523 (572) T ss_dssp HHHHHHHHHHTTSHHHHHHHHHCCCCTTCTTSCCHHHHHHHHHHSHHHHSC------SCSHHHHHHHHHHHHHTSS-HHH T ss_pred HHHHHHHHHHhCCHHHHHHHhccccCCCCCCCccHHHHHHHHHhCcccCCC------ChHHHHHHHHHHHHHHhcC-Cch Confidence 77788888877653221 11111 4666666666 33 3677888888888888865 344 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ...+...++++.|..++.+. ++.++..++.+|.++.... T Consensus 524 ~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~L~~l~~~~ 562 (572) T 4R10_A 524 ARAVESTGVSALLMESRGSQ-YKSVVTYANGVLSNLKRGD 562 (572) T ss_dssp HHHHHTTTTHHHHHHHTTCS-CHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHcChhhHHhHhhCCC-CchHHHHHHHHHHHhhcCC Confidence 44455566778888888766 7788888888888887654 No 66 >5T94_B Guanine nucleotide exchange factor SRM1; Nuclear Import, Importin alpha, RCC1; 2.631A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.78 E-value=9.3e-09 Score=108.50 Aligned_cols=159 Identities=19% Similarity=0.225 Sum_probs=117.7 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++++.|+.++. ..++.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++ T Consensus 254 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~ 327 (542) T 5T94_B 254 VVSQALPTLAKLIY-SMDTETLVDACWAISYLSDGPQE-----AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIV 327 (542) T ss_dssp HHGGGHHHHHHHTT-CCCHHHHHHHHHHHHHHSSSSHH-----HHHHHHHTTCHHHHHHTTSCSSHHHHHHHHHHHHHHT T ss_pred HHhcHHHHHHHHHh-cCCHHHHHHHHHHHHHHcCCCHH-----HHHHHHhCCHHHHHHHHhcCCCHHHHHHHHHHHHHHH Confidence 34556777777777 46677888899999988865332 2333345668888888888888889999999999998 Q NP_000290.2 624 RHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .... . ......++++.|..++.+ .++.++..++++|.+++...+.....+...++++.|+.++.+. ++.++ T Consensus 328 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 400 (542) T 5T94_B 328 TGNDLQTQVVINAGVLPALRLLLSS------PKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVA-EYKTK 400 (542) T ss_dssp TSCHHHHHHHHHTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHHS-CHHHH T ss_pred cCCHHHHHHHHHCChHHHHHHHhhC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCchHHHHHHHHcC-CHHHH Confidence 7632 2 233445678888888866 3678889999999999876555555566666788888888766 77888 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 401 ~~a~~~l~~l~~~~ 414 (542) T 5T94_B 401 KEACWAISNASSGG 414 (542) T ss_dssp HHHHHHHHHHHGGG T ss_pred HHHHHHHHHHHcCC Confidence 99999999888764 No 67 >6KBN_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.78 E-value=9.2e-09 Score=107.80 Aligned_cols=358 Identities=22% Similarity=0.258 Sum_probs=207.0 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....... ....+++.+...+.+.++.++..++.++..++..... ... T Consensus 32 ~~i~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~-~~~ 106 (563) T 6KBN_A 32 GPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLL 106 (563) T ss_dssp CTHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHHSSCCHHHHHHHHHHHHHHTTSHHH-HHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhhhHHH----hccchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcch-HHH Confidence 34566666676677788888888888876532211 2245666777777777777888888888887754322 222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ....+.++.+...+. ..++.++..++.++..++........+.. ++++.|..++... ++++- T Consensus 107 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 169 (563) T 6KBN_A 107 IVEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQ 169 (563) T ss_dssp HHHHTCHHHHHHHHH-SSCHHHHHHHHHHHHHTTCSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHH T ss_pred HHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhCCCchHHHHHhcChHHHHHHHccCC----------------CHHHH Confidence 233355666777665 45667788888888888765433222222 5566666655421 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .....+..+. ..++++.+...++. -+..-...+...|.++. T Consensus 170 ~~a~~~l~~l~---------------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 221 (563) T 6KBN_A 170 RNATGALLNMT---------------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIA 221 (563) T ss_dssp HHHHHHHHHTT---------------------SSHHHHHHHH-TTTCHHHHHHHTTC------SSHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHh Confidence 33333322110 0000111111 12344444444331 11222223333333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ . .........++++.+..++. +.++. T Consensus 222 ~~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~ 251 (563) T 6KBN_A 222 VDEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSR 251 (563) T ss_dssp TSHH------------------------------------------------H-HHHHHHHCSSHHHHHHHHTT-CSCHH T ss_pred CCHH------------------------------------------------H-HHHHHhhchhHHHHHHHHhc-CCCHH Confidence 2000 0 00000012346777888887 46777 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTR 642 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~ 642 (747) ++..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+.. T Consensus 252 ~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ 325 (563) T 6KBN_A 252 VKCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVR 325 (563) T ss_dssp HHHHHHHHHHHHTTSHHH------HHHHHHTTCHHHHHHHHTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHTTCHHHHHT T ss_pred HHHHHHHHHHHHhCChhH------HHHHHHCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHH Confidence 888999999998875321 22334567888888888888888999999999999876433 23344567788888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++... .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++..++.++..+... T Consensus 326 ~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~ 391 (563) T 6KBN_A 326 LLDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALA 391 (563) T ss_dssp TTTCT-----TCHHHHHHHHHHHHHHHHHCSTTHHHHHHTTHHHHHHHHHTSS-CHHHHHHHHHHHHHHTTC T ss_pred HhCCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHhCC-CHHHHHHHHHHHHHHhcC Confidence 87652 2478888999999999876444444455555677777776654 556666666666655543 No 68 >6KBN_C Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.78 E-value=9.2e-09 Score=107.80 Aligned_cols=358 Identities=22% Similarity=0.258 Sum_probs=206.7 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....... ....+++.+...+.+.++.++..++.++..++..... ... T Consensus 32 ~~i~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~-~~~ 106 (563) T 6KBN_C 32 GPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLL 106 (563) T ss_dssp -CHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHHCCSCHHHHHHHHHHHHHHTTSHHH-HHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhhhHHH----hccchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcch-HHH Confidence 34566666676677788888888888876532211 2245666777777777777888888888887754322 222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ....+.++.+...+. ..++.++..++.++..++........+.. ++++.|..++... ++++- T Consensus 107 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 169 (563) T 6KBN_C 107 IVEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQ 169 (563) T ss_dssp HHHTSCSHHHHHHTT-SSCHHHHHHHHHHHHHTTCSHHHHHHHHGGGCHHHHHHHTTSS----------------SHHHH T ss_pred HHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhCCCchHHHHHhcChHHHHHHHccCC----------------CHHHH Confidence 233355666777665 45667788888888888765433222222 5566666655421 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .....+..+. ..++++.+...++. -+..-...+...|.++. T Consensus 170 ~~a~~~l~~l~---------------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 221 (563) T 6KBN_C 170 RNATGALLNMT---------------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIA 221 (563) T ss_dssp HHHHHHHHHHT---------------------SSHHHHHHHH-TTTCHHHHHHHTTC------SSHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHh Confidence 33333322110 0000111111 12344444444331 11222223333333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ . .........++++.+..++. +.++. T Consensus 222 ~~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~ 251 (563) T 6KBN_C 222 VDEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSR 251 (563) T ss_dssp TSHH------------------------------------------------H-HHHHHHSSTTHHHHHHHHTT-CSSHH T ss_pred CCHH------------------------------------------------H-HHHHHhhchhHHHHHHHHhc-CCCHH Confidence 2000 0 00000012346777888887 46777 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTR 642 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~ 642 (747) ++..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+.. T Consensus 252 ~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ 325 (563) T 6KBN_C 252 VKCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVR 325 (563) T ss_dssp HHHHHHHHHHHHTTSHHH------HHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHTTCHHHHHH T ss_pred HHHHHHHHHHHHhCChhH------HHHHHHCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHH Confidence 888999999998875321 22334567888888888888888999999999999876433 23344567788888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++... .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++..++.++..+... T Consensus 326 ~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~ 391 (563) T 6KBN_C 326 LLDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALA 391 (563) T ss_dssp HTTCS-----SCHHHHHHHHHHHHHHHHHCSTTSHHHHTTCHHHHHHHHHTSS-CHHHHHHHHHHHHHHTTC T ss_pred HhCCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHhCC-CHHHHHHHHHHHHHHhcC Confidence 87652 2478888999999999876444444455555677777776654 556666666666655543 No 69 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=97.75 E-value=1.2e-08 Score=115.80 Aligned_cols=373 Identities=17% Similarity=0.153 Sum_probs=224.6 Template_Neff=10.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..+++.+...+.+.++.++..++.+|..+..............+++..+...+.+ .+..++..++.+|..+..... .. T Consensus 149 ~~~l~~L~~lL~~~~~~vr~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~~L~~~~~~~vr~~a~~~L~~l~~~~~-~~ 227 (780) T 2Z6G_A 149 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTSGTLHNLSHHRE-GL 227 (780) T ss_pred cChHHHHHHHccCCCHHHHHHHHHHHHHHhCChHHHHHHHhCCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHH-HH Confidence 3566777777877788899999999998876532221111122466777777765 677888889999988875422 22 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI-A-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv-e-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+..++. ..++.++..++.+|..++.........+ . ++++.|+.++..+ ++ T Consensus 228 ~~~~~~~~i~~L~~lL~-~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~~~~L~~lL~~~----------------~~ 290 (780) T 2Z6G_A 228 LAIFKSGGIPALVNMLG-SPVDSVLFHAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT----------------NV 290 (780) T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC----------------CH Confidence 22333567778888886 5567788899999998886533222222 2 6677777766531 34 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++-..+..+|..-.... ...+..+. ..+++..|...+... .+.+-.+.++.+|. T Consensus 291 ~v~~~a~~~L~~l~~~~--------------------~~~~~~~~-~~~~~~~L~~~l~~~-----~~~~v~~~a~~~L~ 344 (780) T 2Z6G_A 291 KFLAITTDCLQILAYGN--------------------QESKLIIL-ASGGPQALVNIMRTY-----TYEKLLWTTSRVLK 344 (780) T ss_pred HHHHHHHHHHHHHHcCC--------------------HHHHHHHH-HCCcHHHHHHHhCCC-----CCHHHHHHHHHHHH Confidence 44455555554311100 00011110 123444444333221 01112222222332 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) +++... .....+.+.++++.|+.++. +. T Consensus 345 ~l~~~~---------------------------------------------------~~~~~~~~~~~l~~L~~~l~-~~ 372 (780) T 2Z6G_A 345 VLSVCS---------------------------------------------------SNKPAIVEAGGMQALGLHLT-DP 372 (780) T ss_pred HHhCCH---------------------------------------------------HHHHHHHHCCHHHHHHHHcc-CC Confidence 222100 00112245667888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~ 638 (747) +..++..++.+|.+++..... .. ...++++.|+.++.+.+..++..++.+|.+++.. ... ..+...++++ T Consensus 373 ~~~v~~~al~~L~~l~~~~~~------~~--~~~~~l~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~ 444 (780) T 2Z6G_A 373 SQRLVQNCLWTLRNLSDAATK------QE--GMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIE 444 (780) T ss_pred CHHHHHHHHHHHHHHhcCCCC------HH--HHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHH Confidence 778888999999999864321 11 1256788888888888888999999999999876 222 2334456777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL---AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~---~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .|+..+... ..++.++..++.+|.+++...+.. ...+...++++.|+.++....+..++..++.+|.+++... T Consensus 445 ~L~~~l~~~----~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~l~~~~ 520 (780) T 2Z6G_A 445 ALVRTVLRA----GDREDITEPAICALRHLTSRHQDAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCP 520 (780) T ss_pred HHHHHHhcC----CCCHHHHHHHHHHHHHHHcCCccHHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCH Confidence 777766521 035678899999999998653221 2223334567888888875435678899999999988776 Q NP_000290.2 716 ELQGVLRQQ 724 (747) Q Consensus 716 ~~~~~~~~~ 724 (747) +....+... T Consensus 521 ~~~~~~~~~ 529 (780) T 2Z6G_A 521 ANHAPLREQ 529 (780) T ss_pred HHHHHHHhC Confidence 654444333 No 70 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=97.73 E-value=1.3e-08 Score=96.81 Aligned_cols=118 Identities=16% Similarity=0.189 Sum_probs=81.2 Template_Neff=11.800 Q NP_000290.2 263 AIGAYYIQHTCFQ--DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRR 340 (747) Q Consensus 263 ~sAL~aLsnLs~~--~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~s 340 (747) ..++.++.++... .......+...+.++.+..++...+..++..++.++.+++.........+...+.++.++.++. T Consensus 60 ~~~~~~l~~l~~~~~~~~~~~~~~~~g~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~- 138 (252) T 5EWP_B 60 ALSATQLAILASKENEPHYKDAIREANGIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMK- 138 (252) T ss_dssp HHHHHHHHHHHTCTTCTHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTT- T ss_pred HHHHHHHHHHhcCCCCHHHHHHHHHcccHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhh- Confidence 4677788777754 2333344445567788888887777778889999999988654444444444567777888776 Q NP_000290.2 341 TGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 341 s~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) ..++.++..++.++.+++.. ......+.+ ++++.|+.++.. T Consensus 139 ~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 181 (252) T 5EWP_B 139 SNIDGMKAACAQTCRNIFVLDKKYKKEFLKLGGITQLVNLLEL 181 (252) T ss_dssp CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHTTSC T ss_pred CCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHhcC Confidence 55678889999999999864 333334444 777888877764 No 71 >5XGC_A Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF, ONCOPROTEIN; 2.1A {Homo sapiens} Probab=97.72 E-value=1.3e-08 Score=103.51 Aligned_cols=358 Identities=19% Similarity=0.180 Sum_probs=198.3 Template_Neff=13.200 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVS 336 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~ 336 (747) .++.++..++.++..+.... .....+...++++.+...+.+.++.++..++.++..++...+.....+...++++.+.. T Consensus 5 ~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~ 83 (503) T 5XGC_A 5 SQSSCKAKVANIIAEVAKNE-FMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVK 83 (503) T ss_dssp -------------------C-CCCCCSSCHHHHHHHHHHTTCSCHHHHHHHHHHHHHSCCCSHHHHHHHHHTTHHHHHHH T ss_pred chHHHHHHHHHHHHHHhcCh-hhhhhhhhcCcHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCchHHHHHHHCChHHHHHH Confidence 34567777888888887642 22333444567788888888778888999999999988654333333444567778888 Q NP_000290.2 337 LLRRT-GNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRL 414 (747) Q Consensus 337 lL~ss-~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 414 (747) .+... .++.++..++.++..++........+.. ++++.|+.++.... ++++-..+..+|..- T Consensus 84 ~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~---------------~~~~~~~a~~~l~~l- 147 (503) T 5XGC_A 84 LLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQI---------------EHDKREMIFEVLAPL- 147 (503) T ss_dssp HHHHTTTCHHHHHHHHHHHHHHTTSHHHHHHHTTTTHHHHHHHHHHHCC---------------CHHHHHHHHHHHHHH- T ss_pred HHhccCCCHHHHHHHHHHHHHHHccHHHHHHHhcCCHHHHHHHHHHhcC---------------ChhHHHHHHHHHHHH- Confidence 87622 3677888999999998876443333333 67777777776421 233333333333211 Q NP_000290.2 415 GMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRY 494 (747) Q Consensus 415 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 494 (747) ...+..+..+. -.|.+..++..+... ++.........+.+... T Consensus 148 --------------------~~~~~~~~~~~-~~~~~~~l~~~l~~~------~~~~~~~~~~~l~~~~~---------- 190 (503) T 5XGC_A 148 --------------------AENDAIKLQLV-EAGLVECLLEIVQQK------VDSDKEDDITELKTGSD---------- 190 (503) T ss_dssp --------------------TTSHHHHHHHH-HTTHHHHHHHHHHHH------TTCCCHHHHHHHHHHHH---------- T ss_pred --------------------HcCHHHHHHHH-HCCHHHHHHHHHHhc------CCCCCHHHHHHHHHHHH---------- Confidence 11111111111 123444444433221 11111111111100000 Q NP_000290.2 495 RQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSD---AIRTYLNLMGKSKKDATLEACAGA 571 (747) Q Consensus 495 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G---~I~~LL~LL~ss~d~eVr~~AL~a 571 (747) .+.+- ... .+. ...+...+ .++.++.++. +.++.++..++.+ T Consensus 191 ------------------~~~~~----~~~---------~~~---~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~ 235 (503) T 5XGC_A 191 ------------------LMVLL----LLG---------DES---MQKLFEGGKGSVFQRVLSWIP-SNNHQLQLAGALA 235 (503) T ss_dssp ------------------HHHHH----TTS---------HHH---HHHHHGGGTCHHHHHHHHHTT-SSCHHHHHHHHHH T ss_pred ------------------HHHHH----HhC---------Cch---HHHHHhcCcccHHHHHHHHcc-CCCHHHHHHHHHH Confidence 00000 000 000 01112222 6777888887 4677888899999 Q NP_000290.2 572 LQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ----SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTS 646 (747) Q Consensus 572 L~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~----s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s 646 (747) |.+++..... ...+.+.++++.|+.++. +.+..++..++.+|.+++..... ..+...++++.+..++.+ T Consensus 236 L~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~ 309 (503) T 5XGC_A 236 IANFARNDAN------CIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS 309 (503) T ss_dssp HHHHCSSHHH------HHHHHHTTHHHHHHHHHHTTTTTCCHHHHHHHHHHHHHHTCSHHHHHHHHHHTHHHHHHTTTTC T ss_pred HHHHHCChhH------HHHHHHCCHHHHHHHHHHhccccCCHHHHHHHHHHHHHhcCCHHHHHHHHHcCHHHHHHHHHcC Confidence 9999874321 333456688888988887 56788899999999999876433 333445678888888876 Q NP_000290.2 647 HTGNTSNSEDILSSACYTVRNLMASQPQLAKQYF-SSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 647 ~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lv-e~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .++.++..++++|.+++...+.....+. ..++++.++.++.+.....++..++.+|.+++... T Consensus 310 ------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~ 373 (503) T 5XGC_A 310 ------EMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHS 373 (503) T ss_dssp ------CCHHHHHHHHHHHHHHTTTCHHHHHHHHTCHHHHHHHHHHHTCTTCHHHHHHHHHHHHHHHHHH T ss_pred ------CCHHHHHHHHHHHHHHHccCHHHHHHHccccchHHHHHHHHccCCccchHHHHHHHHHHHHHHc Confidence 3678899999999999875433333332 24567788888776523378888999998886544 No 72 >6BW9_A Importin subunit alpha-3, Protein W; Complex, Hendra virus, Importin, Karyopherin; 1.6A {Homo sapiens} Probab=97.70 E-value=1.6e-08 Score=102.40 Aligned_cols=367 Identities=16% Similarity=0.162 Sum_probs=222.4 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ...++.+...+.+.++.++..++.++..+...... ....+...++++.+...+. ..++.++..++.++..++...... T Consensus 8 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 87 (459) T 6BW9_A 8 NTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQ 87 (459) T ss_dssp --CHHHHHHHHTCSSHHHHHHHHHHHHHHHHSSSSCCHHHHHHTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHH T ss_pred ccchHHHHHhccccCHHHHHHHHHHHHHHhcCCCCCCHHHHHHCChHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHH Confidence 34556667777777788899999999888764321 1122333456777777776 456778888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. +.++.++..++.++..++... .....+.. ++++.++.++... .+ T Consensus 88 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~ 151 (459) T 6BW9_A 88 TQAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IP 151 (459) T ss_dssp HHHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHTCSTT---------------SC T ss_pred HHHHhhCCHHHHHHHHhc-CCChHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHhccCCC---------------CC Confidence 333334457777888776 556788889999999887652 22222333 5666666666421 12 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++-..+..++..- ..............+++..+...+.. .+..-...+...| T Consensus 152 ~~~~~~a~~~l~~l---------------------~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 204 (459) T 6BW9_A 152 ITFLRNVTWVMVNL---------------------CRHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWAL 204 (459) T ss_dssp HHHHHHHHHHHHHH---------------------HCCCSSCCCHHHHHHHHHHHHHHTTC------CCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------hcCCCCCCCHHHHHHHHHHHHHHHhc------CCHHHHHHHHHHH Confidence 33333333332211 10000001111223344444433321 1112222223233 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.++.++. + T Consensus 205 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 233 (459) T 6BW9_A 205 SYLTDAG--------------------------------------------------NEQIQMVIDSGIVPHLVPLLS-H 233 (459) T ss_dssp HHHHTSC--------------------------------------------------HHHHHHHHHTTCHHHHGGGGG-C T ss_pred HHHhhcC--------------------------------------------------hHHHHHHHhCChHHHHHHHcC-C Confidence 3322100 001112244567788888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+.+.++++.+..++.+.++.++..++.+|.+++... .. ......+++ T Consensus 234 ~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 308 (459) T 6BW9_A 234 QEVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLV 308 (459) T ss_dssp SSHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTGGGGCHHHHTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCH T ss_pred CCHHHHHHHHHHHHHHHcCCHH-----HHHHHhcccchhcHHHHhhCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHH Confidence 6778888999999999875332 2233344578888888888888889999999999998662 22 233445677 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ-PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.+..++.+ .++.++..++.+|.+++... ......+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 309 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~ 381 (459) T 6BW9_A 309 PMIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 381 (459) T ss_dssp HHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHGGGGCS-CHHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHh------CCHHHHHHHHHHHHHHHHhCCHHHHHHHHHCCcHHHHHHhcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 888888776 36778899999999998532 22333444456788888888766 77889999999999876544 No 73 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=97.66 E-value=2e-08 Score=101.26 Aligned_cols=364 Identities=17% Similarity=0.188 Sum_probs=216.7 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+. ..++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 136 (466) T 5D5K_C 57 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 136 (466) T ss_dssp HHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhhCCCChHHHHHHHHHHHHHcCCChHHHHHHhccchHHHHHHHhcCCCCcHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 345678888889998887654433334444567778888888777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..+.. ++..++.++..++.......... .++++.+..++.. T Consensus 137 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 199 (466) T 5D5K_C 137 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 199 (466) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHSCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHhh-CCCcccccHHHHHHHHHHHHHHHcCCCCCCChHHHHHHHHHHHHHHcC---------------- Confidence 334456677777775 33333 77788888888876433222221 2455666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-.... + .....+ --.+++..|...+.. .+..-...+.. T Consensus 200 ~~~~~~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 252 (466) T 5D5K_C 200 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 252 (466) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------c--------------hHHHHH-HHCChHHHHHHHhcC------CCchHHHHHHH Confidence 13444444444443211100 0 000000 012233333333221 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++.... ......+.+.++++.++.++. T Consensus 253 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 282 (466) T 5D5K_C 253 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 282 (466) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHccChhHhHHHHhh Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 283 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 356 (466) T 5D5K_C 283 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 356 (466) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899988888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .......+.+.++++.+..++.+. ++.++..++.++ T Consensus 357 ~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 429 (466) T 5D5K_C 357 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 429 (466) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHTTHHHHHHHGGGCS-SHHHHHHHHHHH T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCCCHHHHHHHHHcCHHHHHHHHHhCC-cHHHHHHHHHHH Confidence 577788888776 3678889999999999862 122333344456778888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 430 ~~l~~~~~ 437 (466) T 5D5K_C 430 EKYFSVEE 437 (466) T ss_dssp HHHC---- T ss_pred HHhccCCc Confidence 99887543 No 74 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=97.63 E-value=2.4e-08 Score=100.65 Aligned_cols=364 Identities=17% Similarity=0.187 Sum_probs=219.0 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+. ..++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 136 (466) T 4UAF_B 57 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 136 (466) T ss_pred cHHHHHHHhhCCCChHHHHHHHHHHHHHhcCChHHHHHHHccChHHHHHHHhcCCCCCHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 345678888888998887654433334444567778888888777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 137 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 199 (466) T 4UAF_B 137 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 199 (466) T ss_pred HHHCCcHHHHHHHhh-CCCcccccHHHHHHHHHHHHHHHcCCCCCCChhHHHHHHHHHHHHHcC---------------- Confidence 334456677777775 33333 77788888888876433222221 2555666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-... .+ .....+ --.+++..|...+.. .+..-...+.. T Consensus 200 ~~~~~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 252 (466) T 4UAF_B 200 NDPEVLADSCWAISYLTDG------PN--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 252 (466) T ss_pred CCHHHHHHHHHHHHHHhcC------Cc--------------HHHHHH-HHCChHHHHHHHhcC------CChhHHHHHHH Confidence 1344544444444321100 00 000000 012233333333221 11112222233 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++.... ......+.+.++++.+..++. T Consensus 253 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 282 (466) T 4UAF_B 253 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 282 (466) T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHhccCHHHHHHHHhc Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 283 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 356 (466) T 4UAF_B 283 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 356 (466) T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899998888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.++ T Consensus 357 ~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 429 (466) T 4UAF_B 357 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 429 (466) T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCCChHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577788888776 3678889999999999862 122333344456778888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 430 ~~l~~~~~ 437 (466) T 4UAF_B 430 EKYFSVEE 437 (466) T ss_pred HHHccCCc Confidence 99887543 No 75 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=97.63 E-value=2.7e-08 Score=108.38 Aligned_cols=364 Identities=16% Similarity=0.179 Sum_probs=198.9 Template_Neff=11.000 Q NP_000290.2 263 AIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTG 342 (747) Q Consensus 263 ~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~ 342 (747) ..++.+|..+....+. ...+..+.++.++.++...++.++..++.+|..++.........+...++++.|+.++. .. T Consensus 26 ~~~l~~L~~l~~~~~~--~~~~~~~~l~~li~~L~~~~~~v~~~a~~~L~~L~~~~~~~~~~~~~~g~i~~Lv~lL~-~~ 102 (584) T 3L6X_A 26 RGSLASLDSLRKGGPP--PPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLD-HP 102 (584) T ss_dssp --------------CC--CCCCCCCCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHGGG-CS T ss_pred cCchHHHHHHhcCCCC--CCcccCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhh-CC Confidence 3445555555443221 11233467778888887777888999999999988544444444455567888888887 56 Q NP_000290.2 343 NAEIQKQLTGLLWNLSS--TDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMREL 419 (747) Q Consensus 343 d~eVr~~AL~aLsnLas--~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 419 (747) ++.++..++.+|.+++. .......+.. ++++.|+.+|... .|+++-..+.++|.. T Consensus 103 ~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~L~~ll~~~---------------~~~~v~~~a~~~L~~------- 160 (584) T 3L6X_A 103 KKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKA---------------RDMDLTEVITGTLWN------- 160 (584) T ss_dssp SHHHHHHHHHHHHHHTSSSCHHHHHHHHHTTHHHHHHHHHHHC---------------CSHHHHHHHHHHHHH------- T ss_pred CHHHHHHHHHHHHHHhcCCCHHHHHHHHcCChHHHHHHHHHHc---------------CCHHHHHHHHHHHHH------- Confidence 67899999999999987 3344444444 7888888888731 134444455555432 Q NP_000290.2 420 LALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEY 499 (747) Q Consensus 420 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 499 (747) |++.+..+..+... .+..|...+........ ...+ +.. .+. T Consensus 161 --------------L~~~~~~~~~l~~~--~l~~L~~~l~~~~~~~~---~~~~---------------~~~----~~~- 201 (584) T 3L6X_A 161 --------------LSSHDSIKMEIVDH--ALHALTDEVIIPHSGWE---REPN---------------EDC----KPR- 201 (584) T ss_dssp --------------HTTSGGGHHHHHHH--THHHCCCCCCHHHHCCC--------------------------------- T ss_pred --------------HhcCHHHHHHHHHH--HHHHHHHhccccCCCCC---CCCC---------------cCC----CCc- Confidence 11111122222211 22233322221110000 0000 000 000 Q NP_000290.2 500 NARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYH-SDAIRTYLNLMGK-----SKKDATLEACAGALQ 573 (747) Q Consensus 500 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve-~G~I~~LL~LL~s-----s~d~eVr~~AL~aL~ 573 (747) ...+........+|+.|-+. .+......+.+ .++++.|+.++.. ..+..++..++.+|. T Consensus 202 ~~~~~~v~~~a~~~L~~l~~---------------~~~~~~~~l~~~~g~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~ 266 (584) T 3L6X_A 202 HIEWESVLTNTAGCLRNVSS---------------ERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLR 266 (584) T ss_dssp CCCCHHHHHHHHHHHHHHTS---------------SCHHHHHHHHHSTTHHHHHHHHHHHHHHTTCCSCHHHHHHHHHHH T ss_pred ccChHHHHHHHHHHHHHHhc---------------CCHHHHHHHHhCCCHHHHHHHHHHHHhcCCCCChHHHHHHHHHHH Confidence 00000111112222222211 00011111223 4667888887762 125667778888888 Q NP_000290.2 574 NLTASKGLMS--------------------SGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH-----PL 627 (747) Q Consensus 574 nLs~~s~~~s--------------------~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~-----~e 627 (747) +++....... .......+.+.++++.|+.++... ++.++..++.+|.+|+.. .. T Consensus 267 ~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~~~~~~~~~a~~~L~~L~~~~~~~~~~ 346 (584) T 3L6X_A 267 NLSYQVHREIPQAERYQEAAPNVANNTGTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRY 346 (584) T ss_dssp HHHTTHHHHSTTCCC--------------CCCCGGGGGGSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHSSCSHHHHH T ss_pred HHHhhhhccChhHHHHHHhcCcCCCCCCCCChhhhhHhhChhHHHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCccCCHH Confidence 8876421000 000122334568888899988875 788999999999999874 22 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-------SPK 699 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-------d~e 699 (747) . ..+...++++.|+.++.. .+..++..++++|.+|+.. +.....+. .++++.|+.++.... +.. T Consensus 347 ~~~~~~~~~~l~~L~~ll~~------~~~~v~~~a~~~L~~L~~~-~~~~~~l~-~~~l~~L~~~L~~~~~~~~~~~~~~ 418 (584) T 3L6X_A 347 IRSALRQEKALSAIADLLTN------EHERVVKAASGALRNLAVD-ARNKELIG-KHAIPNLVKNLPGGQQNSSWNFSED 418 (584) T ss_dssp HHHHHTSHHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHTT-CSCHHHHH-HHHHHHHHHTSSSSSCSGGGTCCHH T ss_pred HHHHHHHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-hHHHHHHH-cchHHHHHHcCCCCCCCCCcCCCHH Confidence 2 233456788888888876 3678899999999999875 44444443 467888888776431 234 Q NP_000290.2 700 AAEAARLLLSDMWS 713 (747) Q Consensus 700 Vr~aAL~aLsnL~~ 713 (747) ++..++.+|.+++. T Consensus 419 ~~~~~l~~L~~l~~ 432 (584) T 3L6X_A 419 TVISILNTINEVIA 432 (584) T ss_dssp HHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHh Confidence 46778888888773 No 76 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=97.60 E-value=2.9e-08 Score=98.47 Aligned_cols=367 Identities=14% Similarity=0.181 Sum_probs=226.7 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..++.+...+.+.++.++..++..+..+...... ....+...++++.+...+. ..++.++..++.++..++....... T Consensus 5 ~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~ 84 (426) T 4U5L_A 5 WSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQT 84 (426) T ss_dssp CCHHHHHHHHTSSCHHHHHHHHHHHHHHHHCSSCCCHHHHHHTTCHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHH T ss_pred ccHHHHHhhccCCCHHHHHHHHHHHHHHHhcCCCccHHHHHHcCcHHHHHHHhccCCChHHHHHHHHHHHHHhCCCHHHH Confidence 4556667777777888889999999888764322 1222333456777777776 4456788889999988876544333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++..... +..++ T Consensus 85 ~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~~ 152 (426) T 4U5L_A 85 KAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLAC 152 (426) T ss_dssp HHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHHTCHHHHHHHHHTTCHHHHHHTTCSSCG-----------GGSCH T ss_pred HHHHhcCcHHHHHHHhc-CCChHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCCC-----------chhhH Confidence 33344467777888776 5677888999999999887543 2223333 677777777764211 11122 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..++..- ..............+++..+...++. .+..-...+...|. T Consensus 153 ~~~~~~~~~l~~l---------------------~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~ 205 (426) T 4U5L_A 153 GYLRNLTWTLSNL---------------------CRNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAIS 205 (426) T ss_dssp HHHHHHHHHHHHH---------------------TCCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHH---------------------HcCCCCCCCccHHHHHHHHHHHHHhC------CCHHHHHHHHHHHH Confidence 2333333222211 11111111111113344444333321 11122222222232 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-. .....+.+.++++.++.++. +. T Consensus 206 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 234 (426) T 4U5L_A 206 YLTDGPN--------------------------------------------------ERIEMVVKKGVVPQLVKLLG-AT 234 (426) T ss_dssp HHTSSCH--------------------------------------------------HHHHHHHTTTCHHHHHHHHT-CS T ss_pred HHhhCCc--------------------------------------------------HHHHHHhhcChHHHHHHHhc-CC Confidence 2221100 00111234567888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++ T Consensus 235 ~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 309 (426) T 4U5L_A 235 ELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 309 (426) T ss_dssp CHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHH T ss_pred CccHHHHHHHHHHHHhcCCHH-----HHHHHhccchHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHH Confidence 778888999999999875332 233334567888999999888889999999999999875 222 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) .+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 310 ~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 378 (426) T 4U5L_A 310 FLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 378 (426) T ss_dssp HHHHHHHS------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHHGGGSC-CHHHHHHHHHHHHHHHH T ss_pred HHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhcCC-CHHHHHHHHHHHHHHHH Confidence 88888876 3678889999999999874 233334455556788888888876 78899999999999976 No 77 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=97.58 E-value=3.4e-08 Score=101.56 Aligned_cols=364 Identities=17% Similarity=0.184 Sum_probs=217.7 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+. ++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 180 (509) T 4MZ6_E 101 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 180 (509) T ss_dssp HHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhCCCHHHHHH Confidence 455566666543 3678888889988887654443334444567788888888777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 181 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 243 (509) T 4MZ6_E 181 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 243 (509) T ss_dssp HHHTTCHHHHHHHTC-SSCGGGSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTC---------------- T ss_pred HHHCCcHHHHHHHHh-CCChhhhhHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhC---------------- Confidence 334456677777775 33333 77788888888876432221111 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .++++...+..++..-.... + .....+ --.+++..|...++. .+..-...+.. T Consensus 244 ~~~~v~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 296 (509) T 4MZ6_E 244 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 296 (509) T ss_dssp SCHHHHHHHHHHHHHHTSSS------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------h--------------HHHHHH-hhCChHHHHHHHhcC------CCcchHHHHHH Confidence 13444444444443211100 0 000000 012233333333321 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++.... ......+.+.++++.|..++. T Consensus 297 ~L~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 326 (509) T 4MZ6_E 297 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 326 (509) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhh Confidence 333322100 001112245567788888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. ... ..+... T Consensus 327 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 400 (509) T 4MZ6_E 327 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 400 (509) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999998875332 233334557888888888888888999999999999875 222 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+| T Consensus 401 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 473 (509) T 4MZ6_E 401 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 473 (509) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHTTHHHHHHHHTTCS-SHHHHHHHHHHH T ss_pred CCHHHHHHHHhC------CCHHHHHHHHHHHHHHHHHHHHcCCCchHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577888888776 3678888999999998862 123333344456788888888776 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) ..+....+ T Consensus 474 ~~l~~~~~ 481 (509) T 4MZ6_E 474 EKYFSVEE 481 (509) T ss_dssp HHHCC--- T ss_pred HHHCCCCc Confidence 99886543 No 78 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=97.58 E-value=3.4e-08 Score=101.56 Aligned_cols=364 Identities=17% Similarity=0.184 Sum_probs=219.0 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+. ++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 180 (509) T 5UMZ_B 101 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 180 (509) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhCCCHHHHHH Confidence 455566666543 3678888889988887654443334444567788888888777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 181 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 243 (509) T 5UMZ_B 181 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 243 (509) T ss_dssp HHHTTCHHHHHHHTC-SSCGGGSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHHh-CCChhhhhHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhC---------------- Confidence 334456677777775 33333 77788888888876432221111 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .++++...+..++..-.... + .....+ --.+++..|...++. .+..-...+.. T Consensus 244 ~~~~v~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 296 (509) T 5UMZ_B 244 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 296 (509) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------h--------------HHHHHH-hhCChHHHHHHHhcC------CCcchHHHHHH Confidence 13444444444443211100 0 000000 012233333333321 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++.... ......+.+.++++.|..++. T Consensus 297 ~L~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 326 (509) T 5UMZ_B 297 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 326 (509) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhh Confidence 333322100 001112245567788888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. ... ..+... T Consensus 327 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 400 (509) T 5UMZ_B 327 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 400 (509) T ss_dssp -CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999998875332 233334557888888888888888999999999999875 222 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+| T Consensus 401 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 473 (509) T 5UMZ_B 401 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 473 (509) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHTTHHHHHHHHHTCS-CHHHHHHHHHHH T ss_pred CCHHHHHHHHhC------CCHHHHHHHHHHHHHHHHHHHHcCCCchHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577888888776 3678888999999998862 123333344456788888888776 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) ..+....+ T Consensus 474 ~~l~~~~~ 481 (509) T 5UMZ_B 474 EKYFSVEE 481 (509) T ss_dssp HHHCCCCC T ss_pred HHHCCCCc Confidence 99886543 No 79 >5ZHX_D Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF chaperone, ONCOPROTEIN; HET: FAR; 3.5A {Homo sapiens} Probab=97.57 E-value=3.6e-08 Score=99.74 Aligned_cols=332 Identities=20% Similarity=0.193 Sum_probs=197.3 Template_Neff=13.200 Q NP_000290.2 282 QVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSS 359 (747) Q Consensus 282 ~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas 359 (747) .+...++++.+...+.+.++.++..++.++..++...+.....+...++++.+...+. .. ++.++..++.++..++. T Consensus 13 ~l~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~-~~~~~~~v~~~a~~~l~~l~~ 91 (487) T 5ZHX_D 13 PCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLG-IHCQNAALTEMCLVAFGNLAE 91 (487) T ss_dssp ---CHHHHHHHHHHTTCSCHHHHHHHHHHHHTTSTTCHHHHHHHHHTTCHHHHHHHHH-HTSSCSHHHHHHHHHHHHHTT T ss_pred HHhhcCcHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHc-ccCCCHHHHHHHHHHHHHHHc Confidence 3444567778888888778889999999999988654443334444567788888886 43 67888899999999887 Q NP_000290.2 360 TDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 360 ~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .......+.. ++++.|+.++.... ++++-..+..+|..- ...+ T Consensus 92 ~~~~~~~~~~~~~~~~l~~~l~~~~---------------~~~~~~~a~~~l~~l---------------------~~~~ 135 (487) T 5ZHX_D 92 LESSKEQFASTNIAEELVKLFKKQI---------------EHDKREMIFEVLAPL---------------------AEND 135 (487) T ss_dssp SSHHHHHHHHTTHHHHHHHHHHHCC---------------SHHHHHHHHHHHHHH---------------------HTSH T ss_pred chhHHHHHhhCCHHHHHHHHHHhcc---------------ChHHHHHHHHHHHHH---------------------hcCH Confidence 6443333333 67777777776431 333333333333211 1111 Q NP_000290.2 439 AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKS 518 (747) Q Consensus 439 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 518 (747) ..+..+. ..|.++.|+..+... ++.........+..... .+.+.. T Consensus 136 ~~~~~~~-~~~~~~~l~~~l~~~------~~~~~~~~~~~l~~~~~----------------------------~~~~~~ 180 (487) T 5ZHX_D 136 AIKLQLV-EAGLVECLLEIVQQK------VDSDKEDDITELKTGSD----------------------------LMVLLL 180 (487) T ss_dssp HHHHHHH-HHTHHHHHHHHHHHT------SSCCCHHHHHHHHHHHH----------------------------HHHHHT T ss_pred HHHHHHH-HCCHHHHHHHHHHhc------CCCCCHHHHHHHHHHHH----------------------------HHHHHH Confidence 1111111 123444444433321 11111111111110000 000000 Q NP_000290.2 519 DKMMNNNYDCPLPEEETNPKGSGWLYHSD---AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK 595 (747) Q Consensus 519 ~~~~~~~~~~~~~~~~~ni~~~~~lve~G---~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g 595 (747) .+ .+. ...+...+ .++.++.++. +.++.++..++.+|.+++.... ....+.+.+ T Consensus 181 ----~~---------~~~---~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~------~~~~~~~~~ 237 (487) T 5ZHX_D 181 ----LG---------DES---MQKLFEGGKGSVFQRVLSWIP-SNNHQLQLAGALAIANFARNDA------NCIHMVDNG 237 (487) T ss_dssp ----TS---------HHH---HHHHSSSSSSSHHHHHHTTTT-SSCHHHHHHHHHHHHHHCCSHH------HHHHHHTTT T ss_pred ----hc---------cHH---HHHHhhCCCchHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCch------HHHHHHhcC Confidence 00 000 01112222 6777888887 4677888899999999987432 133345567 Q NP_000290.2 596 GLPQIARLLQ----SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 596 iI~~Ll~LL~----s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +++.++.++. +.+..++..++.+|.+++..... ..+...++++.+..++.+ .++.++..++++|.+++. T Consensus 238 ~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 311 (487) T 5ZHX_D 238 IVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS------EMPPVQFKLLGTLRMLID 311 (487) T ss_dssp HHHHHHHHHHHTSSSSCHHHHHHHHHHHHHHTCSHHHHHHHHHHTHHHHHHTTSSC------CCHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHHhcccCCCHHHHHHHHHHHHHhcCChhhHHHHHHcChHHHHHHHHhC------CCHHHHHHHHHHHHHHHh Confidence 8888888887 56788899999999999876433 233445677888888876 367889999999999987 Q NP_000290.2 671 SQPQLAKQYF-SSSMLNNIINLCRSSASP-KAAEAARLLLSDMWSSK 715 (747) Q Consensus 671 ~s~e~~~~Lv-e~giL~~Ll~LL~s~~d~-eVr~aAL~aLsnL~~~~ 715 (747) ..+.....+. ..++++.++.++.+. +. .++..++.+|.+++... T Consensus 312 ~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~a~~~l~~l~~~~ 357 (487) T 5ZHX_D 312 AQAEAAEQLGKNVKLVERLVEWCEAK-DHAGVMGESNRLLSALIRHS 357 (487) T ss_dssp SCHHHHHHHHHCHHHHHHHHHHHTCC-SCCHHHHHHHHHHHHHHHHH T ss_pred hcHHHHHHhccccCHHHHHHHHHHhc-CchhhHHHHHHHHHHHHHHh Confidence 5433333333 245678888888765 44 78888999999986544 No 80 >3NOW_A SD10334p; Armadillo Repeat, Hsp90, Myosin, Tetra-tricopeptide; 2.992A {Drosophila melanogaster} Probab=97.57 E-value=3.6e-08 Score=107.84 Aligned_cols=135 Identities=17% Similarity=0.118 Sum_probs=82.7 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+... .... .....++++.+...+.+.+..++..++.++..+......... T Consensus 289 ~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~-~~~~-~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~ 366 (810) T 3NOW_A 289 EGILQMILAMATTDDELQQRVACECLIAASSK-KDKA-KALCEQGVDILKRLYHSKNDGIRVRALVGLCKLGSYGGQDAA 366 (810) T ss_dssp TTHHHHHHHHHHSSCHHHHHHHHHHHHHHTTS-HHHH-HTTHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTTTTTTS T ss_pred cChHHHHHHHccCCCHHHHHHHHHHHHHHhCC-HHHH-HHHHhhhHHHHHHHhcCCCHHHHHHHHHHHHHHHccCCcccc Confidence 44556666677777788899999999888764 2111 122235677777777777788888999999888764332111 Q NP_000290.2 324 ET-RRQNGIREAVSLLRR-----TGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVI 380 (747) Q Consensus 324 ~l-l~~~IL~~Ll~lL~s-----s~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~ 380 (747) .. ...+.++.+...+.. +.++.++..++.++..++........+.. ++++.+..++. T Consensus 367 ~~~~~~~~~~~l~~~l~~~l~~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 431 (810) T 3NOW_A 367 IRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLAR 431 (810) T ss_dssp CCSSTTTHHHHHHHHHHHHHHCSSCCSSHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHHHHH T ss_pred ccccCCCHHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHcCCHHHHHHHHhChHHHHHHHHHHc Confidence 11 122344445544431 24567888889999888765433333322 46666666665 No 81 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=97.55 E-value=4.1e-08 Score=100.94 Aligned_cols=137 Identities=25% Similarity=0.276 Sum_probs=86.1 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR--SPNQNVQQAAAGALRNLVFRSTTN- 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~--s~d~eVr~~AL~aLs~La~~~~~~- 321 (747) .+++.+...+.+.+..++..++.++..+..........+...+.++.+...+. ..++.++..++.++..++...... T Consensus 267 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~ 346 (538) T 4EV8_A 267 GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAE 346 (538) T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCCChH Confidence 34555666666666778888888888886544433333344556667776665 445677888888888887644321 Q NP_000290.2 322 --KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 322 --~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) .......++++.+...+....++.++..++.++..++........+.. ++++.|..++.. T Consensus 347 ~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~ 409 (538) T 4EV8_A 347 MAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVR 409 (538) T ss_pred HHHHHHHHCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHHcC Confidence 112222356677777775223567888888999888875444433444 677777776653 No 82 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=97.54 E-value=4.4e-08 Score=95.72 Aligned_cols=161 Identities=21% Similarity=0.247 Sum_probs=120.5 Template_Neff=12.500 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~a 618 (747) .+.++++.|+.++....++.++..++++|.+++...+. ....+.. .++++.++.++...+ ..++..++++ T Consensus 162 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~ 236 (339) T 5Z8H_A 162 REVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGI 236 (339) T ss_pred HHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHhcChHHHHHHHhcCCCCCCCHHHHHHHHHH Confidence 45678888888887325677888899999999874332 2334455 688888988887543 6788889999 Q NP_000290.2 619 LSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++. .+.. ..+...++++.++.++.. .++.++..++++|.+++...+.....+.+.++++.|..++. T Consensus 237 l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 310 (339) T 5Z8H_A 237 LRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIH 310 (339) T ss_pred HHHHHHhhccCHHHHHHHHHCCHHHHHHHHHhC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhh Confidence 999873 2222 233445678888888866 36778999999999999844666666667788999999988 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +. ++.++..++.+|.+++...+ T Consensus 311 ~~-~~~v~~~a~~~l~~l~~~~~ 332 (339) T 5Z8H_A 311 SK-HKMIAMGSAAALRNLMANRP 332 (339) T ss_pred CC-CHHHHHHHHHHHHHHHcCCc Confidence 76 78899999999999997654 No 83 >3SL9_B Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: GOL, EDO, PEG, IMD; 2.2A {Homo sapiens} Probab=97.53 E-value=4.8e-08 Score=84.82 Aligned_cols=134 Identities=16% Similarity=0.203 Sum_probs=89.6 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQL-GGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~-~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.++..... ....+... ++++.+..++.. .+..++..++.++.+++.. .... T Consensus 13 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~ 90 (167) T 3SL9_B 13 RAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEA-SRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGL 90 (167) T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHccCHH-HHHHHHhCCchHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHH Confidence 345566666666677788889999998876543 22223332 377778887776 6677888899999888843 3333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~ 381 (747) ..+...+.++.+..++. ..++.++..++.++.+++........++. ++++.|+.++.. T Consensus 91 ~~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 150 (167) T 3SL9_B 91 LAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNK 150 (167) T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHhHHHHHHHcCHHHHHHHHhcC Confidence 33444567778888886 55677888899999998875443333332 677777777654 No 84 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=97.52 E-value=5e-08 Score=99.91 Aligned_cols=156 Identities=17% Similarity=0.216 Sum_probs=117.7 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.++.++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++.. T Consensus 206 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 279 (485) T 4E4V_A 206 EQILPTLVRLLH-HDDPEVLADTCWAISYLTDGPNE-----RIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTG 279 (485) T ss_dssp HHHHHHHHHHTT-SCCHHHHHHHHHHHHHHTSSCHH-----HHHHHHTTTCHHHHHHHHTCSCHHHHHHHHHHHHHHTTS T ss_pred hcHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCChH-----HhhHHhhCChHHHHHHHhcCCChHHHHHHHHHHHHHhcC Confidence 356777888887 46778888999999998875332 223334567888899999888888999999999999876 Q NP_000290.2 626 P-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 ~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) . .. ......++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.|+.++.+. ++.++.. T Consensus 280 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 352 (485) T 4E4V_A 280 TDEQTQVVIDAGALAVFPSLLTN------PKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKA-DFKTQKE 352 (485) T ss_dssp CHHHHHHHHHTTGGGGHHHHHTC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHS-CHHHHHH T ss_pred CHHHHHHHHhCChHHHHHHHhcC------CCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHHhcC-CHHHHHH Confidence 2 22 233445678888888876 3678899999999999876555555566667788888888766 7788889 Q NP_000290.2 704 ARLLLSDMWSS 714 (747) Q Consensus 704 AL~aLsnL~~~ 714 (747) ++.+|.+++.. T Consensus 353 a~~~l~~l~~~ 363 (485) T 4E4V_A 353 AVWAVTNYTSG 363 (485) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHhc Confidence 99999888865 No 85 >1WA5_B GTP-BINDING NUCLEAR PROTEIN RAN, IMPORTIN; NUCLEAR TRANSPORT-COMPLEX, NUCLEAR TRANSPORT, EXPORTIN; HET: GTP; 2.0A {CANIS FAMILIARIS} SCOP: a.118.1.1 Probab=97.52 E-value=5.1e-08 Score=102.06 Aligned_cols=368 Identities=16% Similarity=0.204 Sum_probs=223.8 Template_Neff=12.300 Q NP_000290.2 242 CSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRST 319 (747) Q Consensus 242 ~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~ 319 (747) .....++.++..+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.+|..++.... T Consensus 84 ~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~ 163 (530) T 1WA5_B 84 QLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTS 163 (530) T ss_dssp ---CCHHHHHHHHSCSSHHHHHHHHHHHHHHTCCSSSCSHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCH T ss_pred HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHcChHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCH Confidence 3445566666777777777888888888887653221 1223333457777777776543 6677888899988876443 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) .....+...++++.+...+. ..++.++..++.++..++... .....+.. ++++.|+.++... T Consensus 164 ~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------- 227 (530) T 1WA5_B 164 AQTKVVVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN--------------- 227 (530) T ss_dssp HHHHHHHHTTCHHHHHHHHH-HCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSC--------------- T ss_pred HHHHHHhcCChHHHHHHHHh-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhhCC--------------- Confidence 33333333466777777776 556788899999999988753 23333333 6777777776521 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) ++++...+..+|..-... ...........+++..|...+.. .+......+.. T Consensus 228 -~~~v~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~ 279 (530) T 1WA5_B 228 -KPSLIRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACW 279 (530) T ss_dssp -CHHHHHHHHHHHHHHHCC---------------------SSSCCCHHHHGGGHHHHHHHTTC------CCHHHHHHHHH T ss_pred -CHHHHHHHHHHHHHHHCC---------------------CCCCCCHHHHhhHHHHHHHHHhc------CCHHHHHHHHH Confidence 344444444443221100 00000011122334444333221 11111222222 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++... +......+.+.++++.|+.++. T Consensus 280 ~l~~l~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~ 309 (530) T 1WA5_B 280 AISYLSDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS 309 (530) T ss_dssp HHHHHHSS--------------------------------------------------CHHHHHHHHHTTCHHHHHHGGG T ss_pred HHHHHcCC--------------------------------------------------CHHHHHHHHhCCHHHHHHHHhc Confidence 22222110 0001112345567778888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQ 635 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~g 635 (747) ..++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...+ T Consensus 310 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 383 (530) T 1WA5_B 310 -HESTLVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDAN 383 (530) T ss_dssp -CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTT T ss_pred -CCChhHHHHHHHHHHHHHhCCHH-----HHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCC Confidence 46777888999999998875332 1223344578888999988888889999999999998762 22 3334456 Q NP_000290.2 636 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP---QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 636 iI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) +++.|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++ T Consensus 384 ~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~ 456 (530) T 1WA5_B 384 LIPPLVKLLEV------AEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENIL 456 (530) T ss_dssp CHHHHHHHHHH------SCHHHHHHHHHHHHHHHHHTTTCTHHHHHHHHTTCHHHHHHHTTTC-CHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHc------CCHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCHHHHHHHccCC-CHHHHHHHHHHHHHHH Confidence 77888888876 367889999999999987532 2334444557788888888866 7788999999999998 Q NP_000290.2 713 SSKE 716 (747) Q Consensus 713 ~~~~ 716 (747) ...+ T Consensus 457 ~~~~ 460 (530) T 1WA5_B 457 KMGE 460 (530) T ss_dssp HHHH T ss_pred HHHH Confidence 7654 No 86 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=97.51 E-value=5.1e-08 Score=96.57 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 1EE4_A 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp THHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSCCHHHHHHHHHHHHHHHCCSTTCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666676777888889999999887654433333444467777888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..+... T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 1EE4_A 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHTSS T ss_pred HHHhhHHHHHHHHHH-cCCHHHHHHHHHHHHHHhcC Confidence 233455666666665 45567777778887777654 No 87 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=97.51 E-value=5.1e-08 Score=96.57 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 1EE4_B 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp THHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSCCHHHHHHHHHHHHHHHCCSSSCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666676777888889999999887654433333444467777888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..+... T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 1EE4_B 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHHSS T ss_pred HHHhhHHHHHHHHHH-cCCHHHHHHHHHHHHHHhcC Confidence 233455666666665 45567777778887777654 No 88 >4I2Z_A Protein UNC-45, Heat shock protein; chaperone, myosin folding, protein filaments; 2.9A {Caenorhabditis elegans} Probab=97.51 E-value=6.2e-08 Score=114.34 Aligned_cols=431 Identities=14% Similarity=0.098 Sum_probs=219.4 Template_Neff=8.600 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE--T 325 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~--l 325 (747) +.++.++.+.+..++..++.+|.......... ..+. ...++.|..++.+.++.++..++..|..+.......... . T Consensus 443 ~~l~~~~~~~~~~~~~~a~~~l~~~~~~~~~~-~~i~-~~~v~~L~~l~~~~~~~v~~~A~~~L~kL~~~~~~~~~~~~~ 520 (961) T 4I2Z_A 443 PIMLEMAASQDHLMQGIAAELIVATVSKHERA-INML-KVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKATM 520 (961) T ss_dssp HHHHHHHHSSCHHHHHHHHHHHHTTCCSSSSS-CHHH-HTHHHHHHHHHHCSSHHHHHHHHTTSSCC------------- T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHcChhHHH-HHHH-HhHHHHHHHHHhCCCHHHHHHHHHHHHHHHhcCCcchhhhcc Confidence 33334455556667777777777554332111 1122 235677777777778889999999999887643321110 1 Q NP_000290.2 326 ---RRQNGIREAVSLLRRT--GNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 326 ---l~~~IL~~Ll~lL~ss--~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...+..++... .+..++..++..|..+.........+.. ++++.|++++...-+...-| ++ T Consensus 521 ~~~~~~~L~~~~~~~l~~~~~~~~~~~~~A~e~Layls~~~~vke~l~~d~~~l~~L~~ll~~~~~~~~~~-------~~ 593 (961) T 4I2Z_A 521 KEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDSLLLKALVLLAKKAGALCVYT-------LA 593 (961) T ss_dssp ----CCHHHHHHHHHHHCTTTSCHHHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHHHHHHHGGGGSHH-------HH T ss_pred chHHHHHHHHHHHHHHhcCcCCChHHHHHHHHHHHHHhcCHHHHHHHhcCHHHHHHHHHHHHHcChhHHHH-------HH Confidence 0112344444555411 2456888999999999876655555554 68888888887542111111 00 Q NP_000290.2 399 DPEVFFNATGCL-RKRLG--MRELLALVPQRATSSRVNLSSADAGRQTMR--NYSGLIDSLMAYVQNCVAASRCDDKSVE 473 (747) Q Consensus 399 ~~~~~~~~~~~~-~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 473 (747) ..+-|-+... ++.+. |.+|..+..+.... ...+...+.-....+ --.|.+..|.+.+.. -+....+ T Consensus 594 --~~l~nl~~~~~~~~~~~e~~~l~~~a~~~~~~-~~~~d~~~~v~~r~~~l~~~g~~~~Lv~ll~~------~s~~~r~ 664 (961) T 4I2Z_A 594 --TIYANLSNAFEKPKVDEEMVKLAQFAKHHVPE-THPKDTEEYVEKRVRALVEEGAVPACVAVSKT------ESKNALE 664 (961) T ss_dssp --HHHHHHTTCCCCCC----------CCCCSSTT-CCTTSSTTHHHHHHHHHHHSCSHHHHHHTCCC------SCSHHHH T ss_pred --HHHHHHhcCCCCCCCCHHHHHHHHHHhcCCCC-CCcCCCHHHHHHHHHHHHHCCCHHHHHHHhcC------CCHHHHH Confidence 0111111100 00000 11222221111110 000111111111111 113445555444432 1233445 Q NP_000290.2 474 NCMCVLHNLSYRLDAEVPTRYRQLEYNARNAY-------TE---KSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWL 543 (747) Q Consensus 474 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-------~~---~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~l 543 (747) .+..++++++-.- + .|-.-.+..+-..- ++ .....+..+-.. .-+..+.+... T Consensus 665 ~~~~~l~~l~~~~--~--~R~~iv~~G~v~~Ll~ll~~~~~~~~~~Aa~ALa~l~~-----~~~p~~~~~~~-------- 727 (961) T 4I2Z_A 665 LIARSLLAFAEYE--D--LRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA-----KADPMISFPGQ-------- 727 (961) T ss_dssp HHHHHHHTTSCSS--T--THHHHTTTTHHHHHHHHHHHSCTHHHHHHHHHHHHHSS-----SSCSTTTSTTT-------- T ss_pred HHHHHHHHHhCCH--H--HHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc-----cCChhhhcCCc-------- Confidence 5666777776211 1 11110111100000 00 000000000000 00000111111 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNM 622 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnL 622 (747) ...++++.|+.+|..+.+...+..++.+|.+|+..++. ....+.+.++++.|..+|. +.++.++..|+.++.+| T Consensus 728 ~~~~~i~pLv~lL~~~~~~~~~~eal~ALtnLa~~~~~-----~~~~I~~~~~~~~l~~lL~~~~~~~vr~aA~ell~nL 802 (961) T 4I2Z_A 728 RAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDS-----IRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLNL 802 (961) T ss_dssp HHHHTTSHHHHTTSCCSSCTTHHHHHHHHHHHHSSCHH-----HHHHHHHTTCHHHHGGGTSCSSCHHHHHHHHHHHHHS T ss_pred chhhHHHHHHHHhCCCCChHHHHHHHHHHHHHHcCCHH-----HHHHHHhcChHHHHHHHHhcCCCHHHHHHHHHHHHHH Confidence 01267899999987334556778899999999986533 3445566788999999888 77889999999999999 Q NP_000290.2 623 SRHPLL-HRVM--GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS--SMLNNIINLCRSSAS 697 (747) Q Consensus 623 a~~~e~-~~ll--~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~--giL~~Ll~LL~s~~d 697 (747) +.++.. ..+. ..+.+..++.++.+. .+..++..|+.+|..++. .+.....+++. +.+..+..++.+. + T Consensus 803 ~~~~~~~~~~~~~~~~~~~ll~~l~~~~-----~d~~~~~aA~~aLa~ls~-~~~~~~~i~~~~~~~~~il~~ll~~~-~ 875 (961) T 4I2Z_A 803 LFFEKFYEETVAPGTDRLKLWVLYSAEV-----EEERLSRASAAGFAILTE-DENACARIMDEIKSWPEVFKDIAMHE-D 875 (961) T ss_dssp SSSTTSSTTTTSSCCTHHHHHHHHHHSC-----SSSTHHHHHHHHHHHHHT-CHHHHHHHTTTCTTHHHHHHHHHHCS-S T ss_pred HcCHHHHHhhCCCCCccchhhhHHhccC-----CCHHHHHHHHHHHHHHhC-CHHHHHHHHHHHhchHHHHHHHhhCC-C Confidence 976544 2221 223444454443331 367888999999999884 46655555553 3466677777666 7 Q NP_000290.2 698 PKAAEAARLLLSDMWS-SKELQGVLRQQG 725 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~-~~~~~~~~~~~~ 725 (747) +.++..++.+|.+++. +.++...+-+.| T Consensus 876 ~~l~~ra~~~L~nl~~~~~~~~~~i~~~g 904 (961) T 4I2Z_A 876 AETQRRGLMGIANIMHSSNKLCSEIVSSE 904 (961) T ss_dssp TTHHHHHHHHHTTTSSSCHHHHTCCTTHH T ss_pred HHHHHHHHHHHHHHHhcCHHHHHHHHhcc Confidence 8899999999999965 444444343344 No 89 >5XZX_A Importin subunit alpha-3, Ran-binding protein; nuclear import, TRANSPORT PROTEIN; 3.0A {Homo sapiens} Probab=97.48 E-value=6.3e-08 Score=95.65 Aligned_cols=360 Identities=17% Similarity=0.182 Sum_probs=211.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++...+..... T Consensus 46 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 125 (416) T 5XZX_A 46 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 125 (416) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCChHHHHHHHhcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665 456678888888888887654433333334567777888887777888999999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....++.++..++.++..++.......... .++++.+..++.. .++++ T Consensus 126 ~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~ 189 (416) T 5XZX_A 126 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHH----------------TDVNI 189 (416) T ss_dssp HHHHTCHHHHTTSCSTTSCHHHHHHHHHHHHHHHHCCSSCCCHHHHHHHHHHHHHHTTC----------------CCHHH T ss_pred HHHCccHHHHHHhcCCCCCHHHHHHHHHHHHHHhcCCCCCCChhHHHHHHHHHHHHHhC----------------CCHHH Confidence 33345667777776533456778888888888876533211111 1566666666542 13444 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-... .+ .....+ --.+++..+...++. -+..-...+...|.++ T Consensus 190 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 242 (416) T 5XZX_A 190 LVDTVWALSYLTDA------GN--------------EQIQMV-IDSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 242 (416) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHH-HHHTCHHHHGGGGGC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhc------CH--------------HHHHHH-HHCChHHHHHHHcCC------CCHHHHHHHHHHHHHH Confidence 44444333221100 00 000000 001334444333321 0111111222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.+..++. +.++ T Consensus 243 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 271 (416) T 5XZX_A 243 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 271 (416) T ss_dssp TTSC--------------------------------------------------HHHHHHHHTTTCGGGSHHHHT-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHcCcccHHHHHHHhc-CCCH Confidence 1100 001111234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 272 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 346 (416) T 5XZX_A 272 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 346 (416) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHhcCCHH-----HHHHHHhCCHHHHHHHHHHcCCHHHHHHHHHHHHHHHHhcCHHHHHHHHHCCCHHH Confidence 8888999999998765332 223334556888888888888888999999999999864 2 11 22334567788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDM 711 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL 711 (747) +..++.+ .++.++..++.+|.+++...+... ..+.+.++++.+..++.+. ++.++..++.+|.++ T Consensus 347 l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~~ 415 (416) T 5XZX_A 347 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQF 415 (416) T ss_dssp HHTTTTS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHTTCCTT-CHHHHHHHHHHHHHH T ss_pred HHHHccC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHcCHHHHHHHHhhCC-cHHHHHHHHHHHHHh Confidence 8888776 367888899999999987533211 1233345677888888766 778888888887764 No 90 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=97.46 E-value=6.9e-08 Score=85.28 Aligned_cols=134 Identities=25% Similarity=0.287 Sum_probs=89.4 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (202) T 5MFO_F 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (202) T ss_dssp THHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 34556666666777888889999988876544444444445677888888887778888999999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (202) T 5MFO_F 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 140 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 34456777777776 4566778888888888876422 2222223 55666666554 No 91 >3SL9_E Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: PEG, GOL, IMD, EDO; 2.2A {Homo sapiens} Probab=97.46 E-value=7.2e-08 Score=83.64 Aligned_cols=134 Identities=16% Similarity=0.201 Sum_probs=88.4 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLG-GICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~-IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.++..... ....+.... +++.+..++.. .+..++..++.++..++.. .... T Consensus 13 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~ 90 (167) T 3SL9_E 13 RAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEA-SRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGL 90 (167) T ss_dssp HHHHHHHHHHTCSCHHHHHHHHHHHHHHTTSHH-HHHHHHTCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTS-HHHH T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHccCHH-HHHHHHhCCchHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHH Confidence 345556666666667788889999998876543 222233323 77777777776 6677888889999888743 3333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~ 381 (747) ..+...+.++.+..++. ..++.++..++.++.+++.........+. ++++.|++++.. T Consensus 91 ~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 150 (167) T 3SL9_E 91 LAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNK 150 (167) T ss_dssp HHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCTTHHHHHHHTTHHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHhHHHHHHHcCHHHHHHHHhcC Confidence 33444567777888776 55677888899999998875433333332 667777777654 No 92 >3NOW_A SD10334p; Armadillo Repeat, Hsp90, Myosin, Tetra-tricopeptide; 2.992A {Drosophila melanogaster} Probab=97.46 E-value=7.3e-08 Score=105.35 Aligned_cols=110 Identities=10% Similarity=0.050 Sum_probs=66.2 Template_Neff=12.800 Q NP_000290.2 247 IPKAVQYLSSQ--DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 247 L~~Ll~lL~ss--d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +..++..+.+. +..++..++..|..++... .........+.++.+...+.. .+..++..++.++..++........ T Consensus 8 i~~l~~~l~~~~~~~~~r~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~~~ 86 (810) T 3NOW_A 8 VKQMMDLTFDLATPIDKRRAAANNLVVLAKEQ-TGAELLYKDHCIAKVASLTKVEKDQDIYVNMVHLVAALCENSVERTK 86 (810) T ss_dssp HHHHHHHHHSSCCSSHHHHHHHHHHHHHSSCH-HHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred HHHHHHHHhcCCCcHHHHHHHHHHHHHHhccc-cccHHHHccccHHHHHHHhcCCCCHHHHHHHHHHHHHHHHcCHhHHH Confidence 33445555554 5778888888888887654 222223334567777777731 5678888999999888765332222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .......++.+...+. ..++.++..++.++..++ T Consensus 87 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~~~ 120 (810) T 3NOW_A 87 GVLTELGVPWFMRVLD-QKHENCVSTAQFCLQTIL 120 (810) T ss_dssp HHHHHSCHHHHHHHHH-CCSTTHHHHHHHHHHHHH T ss_pred HHHHHhcHHHHHHHhc-CCChhHHHHHHHHHHHHH Confidence 2222334566666665 345556666666666554 No 93 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=97.44 E-value=7.9e-08 Score=84.90 Aligned_cols=134 Identities=25% Similarity=0.287 Sum_probs=89.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (202) T 5MFO_E 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (202) T ss_dssp CHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 34556666666777888889999988876544434444445677888888887788889999999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (202) T 5MFO_E 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 140 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 34456777777775 4566778888888888876422 2222223 55666666554 No 94 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.44 E-value=8.1e-08 Score=95.04 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.3 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 4XZR_B 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp TCHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSCCHHHHHHHHHHHHHHHCCCTTCCCH T ss_pred chHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666677777888899999999887654433333444467777888887777888888999998887654222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..++.. T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 4XZR_B 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHTSS T ss_pred HHhccHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcC Confidence 233346666666665 44566777777777777654 No 95 >3OPB_A SWI5-dependent HO expression protein 4; HEAT and ARM fold, Myosin; 2.9A {Saccharomyces cerevisiae} Probab=97.44 E-value=9.1e-08 Score=108.58 Aligned_cols=168 Identities=20% Similarity=0.242 Sum_probs=116.3 Template_Neff=10.500 Q NP_000290.2 546 SDAIRTYLNLMGKSK-------------KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVV 612 (747) Q Consensus 546 ~G~I~~LL~LL~ss~-------------d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr 612 (747) .++++.|+.++.... +..++..++.+|.+++.......+......+...++++.|..++.+.++.++ T Consensus 544 ~~~l~~L~~lL~~~~~~~~~~~~~~~~~~~~~~~~al~aL~~l~~~~~~~~~~~~~~~~~~~~~~~~L~~ll~~~~~~v~ 623 (778) T 3OPB_A 544 LNAIPFLFELLPRSTPVDDNPLHNDEQIKLTDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQ 623 (778) T ss_dssp TTHHHHHHHTSCCSSSCSSCC---CCCCCHHHHHHHHHHHHHHHHCCSHHHHHHHHHHHHSHHHHHHHHHGGGCSSHHHH T ss_pred cchHHHHHHHCCCCCCCCCCCCCChhhccHHHHHHHHHHHHHHhcCCCCCCHHHHHHHHhcccHHHHHHHHhhCCCHHHH Confidence 456677777765211 4567778999999988752200000011222224688888888888888899 Q NP_000290.2 613 RSGASLLSNMSRHPLL--HRVMGN------QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS-SS 683 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~--~~ll~~------giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-~g 683 (747) ..++.+|++++..... ..++.. ++++.|+.++.. .+..++..++++|++++...+.....++. .+ T Consensus 624 ~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~l~~L~~ll~~------~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~~ 697 (778) T 3OPB_A 624 RSTLELISNMMSHPLTIAAKFFNLENPQSLRNFNILVKLLQL------SDVESQRAVAAIFANIATTIPLIAKELLTKKE 697 (778) T ss_dssp HHHHHHHHHHHTSGGGTGGGTSCCSSHHHHHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHCHHHHHHHTTCHH T ss_pred HHHHHHHHHHhcChhHHHHHhcCCCChhHHHhHHHHHHHhcC------CCHHHHHHHHHHHHHHHccCHHHHHHHhcCcc Confidence 9999999999987432 233332 678888888876 36789999999999997655554444443 67 Q NP_000290.2 684 MLNNIINLCRSS-ASPKAAEAARLLLSDMWSSKELQG 719 (747) Q Consensus 684 iL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~~~~~~ 719 (747) +++.|+.++.+. .+..++..++++|.+++...+... T Consensus 698 ~i~~L~~~L~~~~~~~~l~~~a~~aL~~L~~~~~~~~ 734 (778) T 3OPB_A 698 LIENAIQVFADQIDDIELRQRLLMLFFGLFEVIPDNG 734 (778) T ss_dssp HHHHHHHHHHHTTTCHHHHHHHHHHHHHHHTTCCSTT T ss_pred HHHHHHHHHHhCCCCHHHHHHHHHHHHHHHhhCCcCC Confidence 889999998862 167789999999999997766544 No 96 >4I2W_A Protein UNC-45, Heat shock 70; chaperone, myosin folding, protein filaments; 3.6A {Caenorhabditis elegans} Probab=97.43 E-value=1e-07 Score=112.49 Aligned_cols=433 Identities=14% Similarity=0.102 Sum_probs=221.5 Template_Neff=8.600 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE-- 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~-- 324 (747) ++.++.++.+.+..++..++.+|..+....... ..+. ...++.|..++.+.++.++..++..|..+.......... T Consensus 442 ~~~l~~l~~~~~~~~~~~a~~~l~~~~~~~~~~-~~i~-~~~v~~L~~l~~~~~~~v~~~A~~~L~kL~~~~~~~~~~~~ 519 (961) T 4I2W_A 442 TPIMLEMAASQDHLMQGIAAELIVATVSKHERA-INML-KVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKAT 519 (961) T ss_dssp HHHHHHHHHSSCHHHHHTTTTTTTTTCCSCSSS-HHHH-HHHHHHHHHHHHCSCHHHHHHHHTTSSSCCC---------- T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHcChhHHH-HHHH-HhHHHHHHHHHhCCCHHHHHHHHHHHHHHHhcCCcchhhhc Confidence 333334455556667777777777554332111 1122 235677777777778889999999999887543321100 Q NP_000290.2 325 T---RRQNGIREAVSLLRRT--GNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 l---l~~~IL~~Ll~lL~ss--~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) . ....+...+..++... .+..++..++..|..+.........+.. .+++.|++++...-+...-|- T Consensus 520 ~~~~~~~~l~~~~~~~l~~~~~~~~~~~~~AvegLayLs~~~~vke~l~~d~~~l~~L~~ll~~~~~~~~~~~------- 592 (961) T 4I2W_A 520 MKEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDSLLLKALVLLAKKAGALCVYTL------- 592 (961) T ss_dssp --CCCTTHHHHHHHHHHHCCSSSCHHHHHHHHHHHHHTCSSHHHHHHHHHCHHHHHHHHHHHHHHGGGSHHHH------- T ss_pred cchHHHHHHHHHHHHHHhcCcCCChHHHHHHHHHHHHHhcCHHHHHHHhcCHHHHHHHHHHHHHcChhHHHHH------- Confidence 1 0112344455555411 2456888999999999876655555554 688889888875422111111 Q NP_000290.2 398 VDPEVFFNATGCL-RKRL--GMRELLALVPQRATSSRVNLSSADAGRQTMRN--YSGLIDSLMAYVQNCVAASRCDDKSV 472 (747) Q Consensus 398 ~~~~~~~~~~~~~-~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~ 472 (747) + ..+-|-+... ++.+ .|.+|..+..+..... ..+...+.-....+. -.|.+..|.+.+.. -+.... T Consensus 593 ~--~~l~nl~~~~~~~~~~~e~~~l~~~a~~~~~~~-~~~d~~~~v~~r~~~l~~~g~~~~Lv~ll~~------~s~~~r 663 (961) T 4I2W_A 593 A--TIYANLSNAFEKPKVDEEMVKLAQFAKHHVPET-HPKDTEEYVEKRVRALVEEGAVPACVAVSKT------ESKNAL 663 (961) T ss_dssp H--HHHHHTTTCCCCCC----------CCCCCSTTC-TTTTSSTTHHHHHHHHHHSSSSHHHHHTTCC------CCSHHH T ss_pred H--HHHHHHhcCCCCCCCCHHHHHHHHHHhcCCCCC-CcCCCHHHHHHHHHHHHHCCCHHHHHHHhcC------CCHHHH Confidence 0 0111111110 0000 0122222211111110 011111111111111 12444444444332 122334 Q NP_000290.2 473 ENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAY---T-E------KSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGW 542 (747) Q Consensus 473 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---~-~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~ 542 (747) +.+..+|++++-.- +. |-.-.+..+-..- . + .....+..+-.. .-+..+.+... T Consensus 664 ~~~~~~l~~l~~~~--~~--R~~ivq~g~~~~Ll~ll~~~~~~~~~~Aa~ALa~l~~-----~~~p~~~~~~~------- 727 (961) T 4I2W_A 664 ELIARSLLAFAEYE--DL--RGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA-----KADPMISFPGQ------- 727 (961) T ss_dssp HHHHHHHHTTSSSS--TT--TTTTTTSSHHHHHHHHHHHSTTHHHHHHHHHHHTTSS-----SSCGGGTSTTT------- T ss_pred HHHHHHHHHHhCCH--HH--HHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc-----cCChhhhcCCc------- Confidence 55566777776211 11 1000001100000 0 0 000000000000 00000111111 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSN 621 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsn 621 (747) ...++++.|+.+|..+.+...+..++.+|.+|+..++. ....+.+.++++.|..+|. +.++.++..|+.++.+ T Consensus 728 -~~~~~i~pLv~lL~~~~~~~~~~eal~ALtnLa~~~~~-----~~~~I~~~~~~~~l~~lL~~~~~~~vr~aA~ell~n 801 (961) T 4I2W_A 728 -RAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDS-----IRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLN 801 (961) T ss_dssp -HHHHTTSGGGTSSSCCSSCTTTTTTHHHHHHHSSSCHH-----HHHHHHHTTCHHHHTTSSSCSTTHHHHHHHHHHHHT T ss_pred -chhhHHHHHHHHhCCCCChHHHHHHHHHHHHHHcCCHH-----HHHHHHhcChHHHHHHHHhcCCCHHHHHHHHHHHHH Confidence 11267899999987334556778899999999986533 3445556788899998888 7788999999999999 Q NP_000290.2 622 MSRHPLL-HRVM--GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS--SMLNNIINLCRSSA 696 (747) Q Consensus 622 La~~~e~-~~ll--~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~--giL~~Ll~LL~s~~ 696 (747) |+.++.. ..+. ..+.+..++.++.+. .++.++..|+.+|+.++. .+.....+++. +.+..|..++.+. T Consensus 802 L~~~~~~~~~~~~~~~~~~~ll~~l~~~~-----~d~~~~~aA~~aLa~l~~-~~~~~~~i~~~~~~~~~~l~~ll~~~- 874 (961) T 4I2W_A 802 LLFFEKFYEETVAPGTDRLKLWVLYSAEV-----EEERLSRASAAGFAILTE-DENACARIMDEIKSWPEVFKDIAMHE- 874 (961) T ss_dssp TSSSSSSSTTTSSSCSSCHHHHHHHHHCC-----SSSTHHHHHHHHHHHHHS-SHHHHHHTGGGCTTHHHHHHHHHHCS- T ss_pred HHcCHHHHHhhCCCCCccchhhhHHhccC-----CCHHHHHHHHHHHHHHhC-CHHHHHHHHHHHhchHHHHHHHhhCC- Confidence 9976544 2221 223444444443331 357888999999999884 45555555553 3466677777666 Q NP_000290.2 697 SPKAAEAARLLLSDMWS-SKELQGVLRQQGF 726 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~-~~~~~~~~~~~~~ 726 (747) ++.++..++.+|.+++. +.+....+.+.|. T Consensus 875 ~~~l~~ra~~~l~nl~~~~~~~~~~~~~~g~ 905 (961) T 4I2W_A 875 DAETQRRGLMGIANIMHSSNKLCSEIVSSEV 905 (961) T ss_dssp STTHHHHHHHHTHHHHSSCSHHHHCCSSHHH T ss_pred CHHHHHHHHHHHHHHHhcCHHHHHHHHhccH Confidence 78899999999999965 4444443444443 No 97 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=97.42 E-value=9.1e-08 Score=88.50 Aligned_cols=221 Identities=45% Similarity=0.773 Sum_probs=134.5 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQD--EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd--~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..++.++..+...+ ..++..++.++.+++.........+...++++.+..++...+..++..++.+|.+++....... T Consensus 8 ~~i~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~ 87 (233) T 3TT9_A 8 MTLERAVSMLEADHMLPSRISAAATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNK 87 (233) T ss_dssp CCHHHHHHTCCSSCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHTTHHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHH T ss_pred hHHHHHHHHHhhcCCCHHHHHHHHHHHHHHHccCHHHHHHHHHcchHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCCcHH Confidence 34556666666544 6788888899988876444444445555678888888877777888999999999886444444 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) ..+...+.++.++.++....+..++..++.++.+++........+.. +++..+..++.... .+-.....+.....+++ T Consensus 88 ~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ll~~~~-~~~~~~~~~~~~~~~~~ 166 (233) T 3TT9_A 88 LEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSNDKLKNLMITEALLTLTENIIIPFS-GWPEGDYPKANGLLDFD 166 (233) T ss_dssp HHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSGGGHHHHHHHHHHHHCCCCCHHHH-CCCGGGCCCCCTTCCHH T ss_pred HHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHHHHccCHHHHHHhhhhcHHHHHHHHHhhcc-CCCCCCCCcccCCCcHH Confidence 44445567777887775234567888999999999875544444444 66666666665432 11111222222334566 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSS-ADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) +...+.++|.. +.. .+..++.+....++++.|...++....-...+.+-.+++..+|. T Consensus 167 ~~~~a~~~l~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~L~ 225 (233) T 3TT9_A 167 IFYNVTGCLRN---------------------MSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILH 225 (233) T ss_dssp HHHHHHHHHHH---------------------HTTSCHHHHHHHHTSTTHHHHHHHHHHHHHHTTCTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHH---------------------HHhcCHHHHHHHHHcccHHHHHHHHHHcccccCCCChHHHHHHHHHHH Confidence 65555555432 111 22334444444455666666554421101115567788999999 Q NP_000290.2 481 NLSYRLD 487 (747) Q Consensus 481 ~~~~~~~ 487 (747) ||+++.+ T Consensus 226 ~l~~~~~ 232 (233) T 3TT9_A 226 NLSYQLE 232 (233) T ss_dssp HHCCCCC T ss_pred Hhhhccc Confidence 9987654 No 98 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=97.42 E-value=9.4e-08 Score=103.88 Aligned_cols=378 Identities=17% Similarity=0.155 Sum_probs=229.8 Template_Neff=11.700 Q NP_000290.2 241 ECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 241 ~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~ 319 (747) +....+++.+...+.+.++.++..++.++..+..............+++..+...+. ..+..++..++.+|..++.... T Consensus 10 ~~~~~~i~~L~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~ 89 (644) T 2Z6H_A 10 ELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHRE 89 (644) T ss_pred HHhCCHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCcHHHHHHHhCCChHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCHH Confidence 344566777888888778889999999999887653222111111346666777666 4566788888888888865432 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK-EELIA-DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~-~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) ....+...+.++.+...+. ..++.++..++.++..++...... ..+.. ++++.|+.++... T Consensus 90 -~~~~~~~~~~i~~L~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~--------------- 152 (644) T 2Z6H_A 90 -GLLAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT--------------- 152 (644) T ss_pred -HHHHHHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCC--------------- Confidence 2223333467777888876 556788889999999988653322 22222 6677777766531 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) ++++...+..+|..-.... ...+..... .++++.|...+... .+.+....++. T Consensus 153 -~~~~~~~a~~~L~~l~~~~--------------------~~~~~~~~~-~~~~~~L~~~l~~~-----~~~~~~~~a~~ 205 (644) T 2Z6H_A 153 -NVKFLAITTDCLQILAYGN--------------------QESKLIILA-SGGPQALVNIMRTY-----TYEKLLWTTSR 205 (644) T ss_pred -CHHHHHHHHHHHHHHhcCC--------------------HHHHHHHHH-CCcHHHHHHHhcCC-----CCHHHHHHHHH Confidence 3344444444443211000 000111111 23444444444321 12222233333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.+++..- .....+.+.++++.|+.++. T Consensus 206 ~L~~l~~~~---------------------------------------------------~~~~~~~~~~~l~~l~~~l~ 234 (644) T 2Z6H_A 206 VLKVLSVCS---------------------------------------------------SNKPAIVEAGGMQALGLHLT 234 (644) T ss_pred HHHHHccCh---------------------------------------------------HHHHHHHHCCHHHHHHHHhc Confidence 333332110 00012345667888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQ 635 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~g 635 (747) ..+..++..++++|.+++..... ... ..++++.|+.++.+.+..++..++.+|.+++.. ... ..+...+ T Consensus 235 -~~~~~~~~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 305 (644) T 2Z6H_A 235 -DPSQRLVQNCLWTLRNLSDAATK------QEG--MEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVG 305 (644) T ss_pred -CCCHHHHHHHHHHHHHHhcCCCC------HHH--HCchHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCC Confidence 46778888999999999875321 111 256788888888888888999999999999865 222 2334556 Q NP_000290.2 636 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL---AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 636 iI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~---~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) +++.++..+... ..+..++..++.+|.+++...+.. ...+...++++.|+.++....+..++..++.+|.+++ T Consensus 306 ~l~~L~~~l~~~----~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~ 381 (644) T 2Z6H_A 306 GIEALVRTVLRA----GDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLA 381 (644) T ss_pred HHHHHHHHHhcC----CCCHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHh Confidence 777777776521 035678889999999998753322 2333344677888888875435678899999999999 Q NP_000290.2 713 SSKELQGVLRQQGF 726 (747) Q Consensus 713 ~~~~~~~~~~~~~~ 726 (747) ...+.+..+.+.|. T Consensus 382 ~~~~~~~~l~~~~~ 395 (644) T 2Z6H_A 382 LCPANHAPLREQGA 395 (644) T ss_pred cCHHHHHHHHHCCc Confidence 87776655555443 No 99 >4U2X_E eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=97.42 E-value=9.4e-08 Score=83.77 Aligned_cols=116 Identities=17% Similarity=0.149 Sum_probs=80.4 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ 324 (747) +++.+..++.+.++.++..++.++.++....+.....+...++++.+...+.+.+..++..++.++.+++.. ....... T Consensus 9 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 88 (175) T 4U2X_E 9 ALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 88 (175) T ss_dssp SSHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHH T ss_pred hHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChHHHHHHHHHhcCHHHHHHHHHHHHHHcCCCCHHHHHH Confidence 455566666667788889999999998865443333444456777888887777778888899999988753 2222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...+.++.+...+. ..++.++..++.++.+++.... T Consensus 89 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~ 125 (175) T 4U2X_E 89 LVALGCIKPLCDLLT-VMDSKIVQVALNGLENILRLGE 125 (175) T ss_dssp HHHHTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHHHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhcH Confidence 333456777777776 5567788888899888887543 No 100 >4RV1_D Engineered Protein OR497; STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE; 2.573A {SYNTHETIC CONSTRUCT} Probab=97.42 E-value=9.1e-08 Score=94.28 Aligned_cols=363 Identities=20% Similarity=0.249 Sum_probs=217.4 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..+........... T Consensus 45 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 124 (420) T 4RV1_D 45 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 124 (420) T ss_dssp HHHHHHHTTSCSCSSSHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhCCChHHHHHH Confidence 45556666666777888899999988876543333333334567777777777778888899999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++... ++++- T Consensus 125 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 187 (420) T 4RV1_D 125 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTST----------------DSEVQ 187 (420) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCS----------------SHHHH T ss_pred HHcCHHHHHHHHHh-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCC----------------CHHHH Confidence 33456777777776 55677888899999988864322 222222 5566666655421 23332 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++.. +.. ........-.-.++++.+...+++ -+..-...+...|.++. T Consensus 188 ~~~~~~l~~---------l~~------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 240 (420) T 4RV1_D 188 KEAARALAN---------IAS------------GPTSAIKAIVDAGGVEVLVKLLTS------TDSEVQKEAARALANIA 240 (420) T ss_dssp HHHHHHHHH---------HHT------------SCHHHHHHHHTTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHH---------HhC------------CCHHHHHHHHHCCHHHHHHHHhhC------CCHHHHHHHHHHHHHHh Confidence 222222221 100 000000000001233333322221 01111122222222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ... ......+.+.++++.++..+. +.++. T Consensus 241 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~ 269 (420) T 4RV1_D 241 SGP--------------------------------------------------DEAIKAIVDAGGVEVLVKLLT-STDSE 269 (420) T ss_dssp TSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSSHH T ss_pred CCC--------------------------------------------------HHHHHHHhhccHHHHHHHHhC-CCCHH Confidence 100 001111234567777888887 46677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++... .. ......++++.+. T Consensus 270 ~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 344 (420) T 4RV1_D 270 VQKEAARALANIASGPDE-----AIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLV 344 (420) T ss_dssp HHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcChHHHHHHHHHCCHHHHHH Confidence 888899999998875332 1223344578888888888888889999999999998763 22 2333446777788 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++..++.+|..+.... T Consensus 345 ~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 411 (420) T 4RV1_D 345 KLLTS------TDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLQKLLTST-DSEVQKEAQRALENIKSGG 411 (420) T ss_dssp HHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHHHHHHTS T ss_pred HHhCC------CCHHHHHHHHHHHHHHHcCChhHHHHHHhccHHHHHHHHcCCC-CHHHHHHHHHHHHhhccCC Confidence 77776 3678899999999999876444444455556788888888766 7789999999999887644 No 101 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=97.41 E-value=9.4e-08 Score=96.14 Aligned_cols=158 Identities=18% Similarity=0.251 Sum_probs=116.4 Template_Neff=13.000 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 170 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 243 (456) T 4BQK_A 170 TRPALPALARLIH-SNDEEVLTDACWALSYLSDGTND-----KIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVT 243 (456) T ss_dssp HTTHHHHHHHHTT-CCCHHHHHHHHHHHHHHTSSSHH-----HHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCChH-----HHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46778888899999998865332 22333456788889999888888899999999999987 Q NP_000290.2 625 HPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) ... . ..+...++++.+..++... .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 244 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 317 (456) T 4BQK_A 244 GDDAQTQCIIDHQALPCLLSLLTQN-----LKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTA-EFDIKK 317 (456) T ss_dssp SCHHHHHHHHTTTHHHHHHHHHHSC-----CCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHHHHS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHHHcC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhcC-CHHHHH Confidence 632 2 2334446777888877652 2577889999999999876555555555666788888888766 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 318 ~a~~~l~~l~~~ 329 (456) T 4BQK_A 318 EAAWAISNATSG 329 (456) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHcC Confidence 999999988863 No 102 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=97.41 E-value=1e-07 Score=99.66 Aligned_cols=160 Identities=15% Similarity=0.207 Sum_probs=115.0 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.|+.++....+..++..++.+|.+++..... ........++++.+..++.+.++.++..++.+|.+++ T Consensus 196 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~ 270 (521) T 5TBK_C 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDP-----PPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT 270 (521) T ss_dssp HHTTCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSS-----CCCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHH T ss_pred HHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCC-----CCCHHHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHh Confidence 45567788888886323446778899999998865321 1112223567888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++ T Consensus 271 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 343 (521) T 5TBK_C 271 DAGNEQIQMVIDSGIVPHLVPLLSH------QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHP-KEKIN 343 (521) T ss_dssp HHCHHHHHHHHHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCGGGHHHHHTCS-CHHHH T ss_pred ccChHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHhHHHHhhCC-CHHHH Confidence 76 222 233445677788888765 3677888999999999876444444555557788888888766 78889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 344 ~~a~~~l~~l~~~~ 357 (521) T 5TBK_C 344 KEAVWFLSNITAGN 357 (521) T ss_dssp HHHHHHHHHHTTSC T ss_pred HHHHHHHHHHhCCC Confidence 99999999988653 No 103 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=97.41 E-value=1e-07 Score=99.66 Aligned_cols=160 Identities=15% Similarity=0.207 Sum_probs=115.0 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.|+.++....+..++..++.+|.+++..... ........++++.+..++.+.++.++..++.+|.+++ T Consensus 196 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~ 270 (521) T 5TBK_D 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDP-----PPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT 270 (521) T ss_dssp HHTCCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSS-----CCCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHH T ss_pred HHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCC-----CCCHHHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHh Confidence 45567788888886323446778899999998865321 1112223567888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++ T Consensus 271 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 343 (521) T 5TBK_D 271 DAGNEQIQMVIDSGIVPHLVPLLSH------QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHP-KEKIN 343 (521) T ss_dssp HHCHHHHHHHHHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCGGGHHHHHHCS-CHHHH T ss_pred ccChHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHhHHHHhhCC-CHHHH Confidence 76 222 233445677788888765 3677888999999999876444444555557788888888766 78889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 344 ~~a~~~l~~l~~~~ 357 (521) T 5TBK_D 344 KEAVWFLSNITAGN 357 (521) T ss_dssp HHHHHHHHHHTTSC T ss_pred HHHHHHHHHHhCCC Confidence 99999999988653 No 104 >4U2X_F eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=97.37 E-value=1.2e-07 Score=83.04 Aligned_cols=116 Identities=17% Similarity=0.149 Sum_probs=79.8 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ 324 (747) +++.+..++.+.++.++..+++++.++..........+...++++.+..++.+.++.++..++.++..++.. ....... T Consensus 9 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 88 (175) T 4U2X_F 9 ALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 88 (175) T ss_dssp CSHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHH T ss_pred hHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHHHhCCHHHHHHHHHHHHHHhcCCCHHHHHH Confidence 445566666666778889999999998865443333444446777888877776778888899999988753 2222233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...+.++.+...+. ..++.++..++.++.+++.... T Consensus 89 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~ 125 (175) T 4U2X_F 89 LVALGCIKPLCDLLT-VMDSKIVQVALNGLENILRLGE 125 (175) T ss_dssp HHHHTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHHHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcch Confidence 333456777777776 5566788888888888877543 No 105 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=97.37 E-value=1.2e-07 Score=87.00 Aligned_cols=113 Identities=25% Similarity=0.271 Sum_probs=78.0 Template_Neff=12.900 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+. T Consensus 10 ~~~~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 89 (247) T 4V3Q_A 10 LPQMVQQLNSPDQQELQSALRKLSQIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVI 89 (247) T ss_dssp HHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHHcCChhhhhhhhccCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcHHHHHHHH Confidence 34455566677788888899999888765444444444556778888888777778888999999988765443333333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ..++++.+...+. +.++.++..++.++..++.. T Consensus 90 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 122 (247) T 4V3Q_A 90 DAGALPALVQLLS-SPNEQILQEALWTLGNIASG 122 (247) T ss_dssp HTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 4456777777776 45667777788888777753 No 106 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=97.34 E-value=1.5e-07 Score=97.01 Aligned_cols=136 Identities=21% Similarity=0.259 Sum_probs=84.7 Template_Neff=12.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE-SAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~-~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+..++...++.++..++.+|.+++.... .....+...++++.+..++. ..+..++..++.++.+++....... T Consensus 243 ~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 322 (458) T 3NMZ_A 243 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 322 (458) T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCChhHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhH Confidence 456667777777777888999999999887543 22334444567777888777 5567788889999999886433333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLSS----TDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLas----~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..+.. .+.++.+..++.. ..+..++..++.++.+++. .......+.+ ++++.|+.++. T Consensus 323 ~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~ 389 (458) T 3NMZ_A 323 ADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLK 389 (458) T ss_pred HHHHHhcChHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhC Confidence 33333 4566666666641 1234566677777766652 2222222333 56666666654 No 107 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=97.34 E-value=1.6e-07 Score=102.08 Aligned_cols=377 Identities=16% Similarity=0.154 Sum_probs=185.5 Template_Neff=11.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.|+.++.+.+..++..++.+|.+++.. .......+...+.++.++.++.. .+..++..++.+|.+++.... ... T Consensus 91 ~i~~Lv~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~L~~~~~-~~~ 169 (584) T 3L6X_A 91 GIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDS-IKM 169 (584) T ss_dssp HHHHHHHGGGCSSHHHHHHHHHHHHHHTSSSCHHHHHHHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHTTSGG-GHH T ss_pred cHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCCHHHHHHHHcCChHHHHHHHHHHcCCHHHHHHHHHHHHHHhcCHH-HHH Confidence 466677777777788999999999999874 34444445556778888888875 366788888999988875432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLR-----------------RTGNAEIQKQLTGLLWNLSSTDE-LKEELIA--DALPVLADRVIIPF 383 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~-----------------ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve--giLe~Lv~LL~~~~ 383 (747) .+... .+..+...+. ...+..++..++.+|.+++.... ....+.. ++++.|+.+|.... T Consensus 170 ~l~~~-~l~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~g~v~~L~~~l~~~~ 248 (584) T 3L6X_A 170 EIVDH-ALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEI 248 (584) T ss_dssp HHHHH-THHHCCCCCCHHHHCCC----------CCCCHHHHHHHHHHHHHHTSSCHHHHHHHHHSTTHHHHHHHHHHHHH T ss_pred HHHHH-HHHHHHHhccccCCCCCCCCCcCCCCcccChHHHHHHHHHHHHHHhcCCHHHHHHHHhCCCHHHHHHHHHHHHh Confidence 22222 4444444431 12235677888899998887542 3333333 67788888876432 Q NP_000290.2 384 SGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMR--E------LLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLM 455 (747) Q Consensus 384 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 455 (747) .. ...++++.-++..+|+.-..-. + .....+.-....+ .....++..+. -.+.++.|. T Consensus 249 ~~----------~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~l~-~~~~~~~l~ 314 (584) T 3L6X_A 249 GQ----------KDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTG---TSPARGYELLF-QPEVVRIYI 314 (584) T ss_dssp HT----------TCCSCHHHHHHHHHHHHHHTTHHHHSTTCCC-----------------CCCCGGGGGG-SHHHHHHHH T ss_pred cC----------CCCChHHHHHHHHHHHHHHhhhhccChhHHHHHHhcCcCCCCCC---CCChhhhhHhh-ChhHHHHHH Confidence 10 0123334444444443211100 0 0000000000000 00111122221 134555555 Q NP_000290.2 456 AYVQNCVAASRCDDKSVENCMCVLHNLSYRLD---AEVPTRYRQLEYNAR----------NAYTEKSSTGCFSNKSDKMM 522 (747) Q Consensus 456 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~~~~~~~~ 522 (747) ..+... -+..-.+.+..+|.||+..-. .++....+ +...- +.........+..|-+. T Consensus 315 ~ll~~~-----~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~--~~~~l~~L~~ll~~~~~~v~~~a~~~L~~L~~--- 384 (584) T 3L6X_A 315 SLLKES-----KTPAILEASAGAIQNLCAGRWTYGRYIRSALR--QEKALSAIADLLTNEHERVVKAASGALRNLAV--- 384 (584) T ss_dssp HHHHHC-----CCHHHHHHHHHHHHHHHSSCSHHHHHHHHHHT--SHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHT--- T ss_pred HHHHcC-----CCHHHHHHHHHHHHHHhCCCccCCHHHHHHHH--HcChHHHHHHHhcCCCHHHHHHHHHHHHHHhc--- Confidence 554431 144556777888888876321 11111000 00000 00001111111111100 Q NP_000290.2 523 NNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK--------KDATLEACAGALQNLTASKGLMSSGMSQLIGLKE 594 (747) Q Consensus 523 ~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~--------d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~ 594 (747) +...... +..++++.|+.+|.. . +..++..++.+|.+++..... ....+.+. T Consensus 385 -------------~~~~~~~-l~~~~l~~L~~~L~~-~~~~~~~~~~~~~~~~~l~~L~~l~~~~~~-----~~~~l~~~ 444 (584) T 3L6X_A 385 -------------DARNKEL-IGKHAIPNLVKNLPG-GQQNSSWNFSEDTVISILNTINEVIAENLE-----AAKKLRET 444 (584) T ss_dssp -------------TCSCHHH-HHHHHHHHHHHTSSS-SSCSGGGTCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHHT T ss_pred -------------ChHHHHH-HHcchHHHHHHcCCC-CCCCCCcCCCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHC Confidence 0011111 224788888888863 3 334467888888888764332 23444577 Q NP_000290.2 595 KGLPQIARLLQSG--NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPE-VTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 595 giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~-Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ++++.|+.++... +..++..|+.+|.+++..... ..+...++++. +..++... ..++.++..++.+|.++.. T Consensus 445 ~~l~~L~~ll~~~~~~~~v~~~a~~~L~~l~~~~~~~~~l~~~g~~~~~l~~~~~~~----~~~~~~~~~a~~~L~~l~~ 520 (584) T 3L6X_A 445 QGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNA----SRSQSSHSYDDSTLPLIDR 520 (584) T ss_dssp THHHHHHHHHTCSSSCHHHHHHHHHHHHHHHTSHHHHHHHHTTTCCGGGGCCC--------------------------- T ss_pred CHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHHHHHHHHHcCCchhhceeccccc----ccCCCCCCcccccccccCC Confidence 8999999998753 477899999999999876444 33445566676 55553211 0357788889999999987 Q NP_000290.2 671 SQ 672 (747) Q Consensus 671 ~s 672 (747) .. T Consensus 521 ~~ 522 (584) T 3L6X_A 521 NQ 522 (584) T ss_dssp -- T ss_pred CC Confidence 53 No 108 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=97.33 E-value=1.5e-07 Score=85.77 Aligned_cols=113 Identities=20% Similarity=0.252 Sum_probs=78.4 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++.+++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (243) T 5MFI_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 84 (243) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666777888899999998876544443444445677888888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++++.+...+. ..++.++..++.++..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 117 (243) T 5MFI_B 85 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIAS 117 (243) T ss_dssp HHTTCHHHHHHHTS-SSCHHHHHHHHHHHHHHTT T ss_pred HHcCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHc Confidence 33456777777775 4566677777888877775 No 109 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=97.33 E-value=1.5e-07 Score=85.77 Aligned_cols=113 Identities=20% Similarity=0.252 Sum_probs=77.5 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++.+++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (243) T 5MFJ_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 84 (243) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCTTTC-CHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666777888899999998876544443444445677888888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++++.+...+. ..++.++..++.++..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 117 (243) T 5MFJ_B 85 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIAS 117 (243) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHT T ss_pred HHcCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHc Confidence 33456777777775 4566677777888877775 No 110 >5VOZ_P V-type proton ATPase catalytic subunit; V-ATPase, SidK, rotational state 3;{Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.30 E-value=2.1e-07 Score=101.03 Aligned_cols=134 Identities=14% Similarity=0.103 Sum_probs=89.5 Template_Neff=8.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... ... T Consensus 124 ~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~li~~L~~~~~~~~~~~a~~~L~~L~~~~-~~r 200 (478) T 5VOZ_P 124 LEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EYR 200 (478) T ss_dssp HHHHTTSTTSS-CHHHHHHHHHHHHHHHTSS-SCCCHHHHHHHHSSHHHHHHHHCSSCHHHHHHHHHHHHHHTTSH-HHH T ss_pred HHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhccCCccHHHHHHHHHHHHcCCh-HHH Confidence 45666667766 6677888888888887643 22112223456666 7777753 35667888899999888643 333 Q NP_000290.2 323 LETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~~ 381 (747) ..+.. .+.++.|+.++... .++.++..++.++..|+........+.. ++++.|+++++. T Consensus 201 ~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~l~~~~~~~i~~Lv~ll~~ 280 (478) T 5VOZ_P 201 DVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKI 280 (478) T ss_dssp HHHHHSTTSSHHHHHHHHHHHHHSCSSCCCTTTSSSHHHHHHHHHHHHHHHHHTTSHHHHHHHHHHSHHHHGGGHHHHHH T ss_pred HHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHhc Confidence 33444 35777888877621 2567888899999999876555555543 688889998886 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 281 ~ 281 (478) T 5VOZ_P 281 T 281 (478) T ss_dssp C T ss_pred c Confidence 4 No 111 >5D80_H V-type proton ATPase catalytic subunit; Hydrolase, Autoinhibition; 6.202A {Saccharomyces cerevisiae} Probab=97.30 E-value=2.1e-07 Score=101.03 Aligned_cols=134 Identities=14% Similarity=0.103 Sum_probs=89.5 Template_Neff=8.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... ... T Consensus 124 ~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~li~~L~~~~~~~~~~~a~~~L~~L~~~~-~~r 200 (478) T 5D80_H 124 LEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EYR 200 (478) T ss_pred HHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhccCCccHHHHHHHHHHHHcCCh-HHH Confidence 45666667766 6677888888888887643 22112223456666 7777753 35667888899999888643 333 Q NP_000290.2 323 LETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~~ 381 (747) ..+.. .+.++.|+.++... .++.++..++.++..|+........+.. ++++.|+++++. T Consensus 201 ~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~l~~~~~~~i~~Lv~ll~~ 280 (478) T 5D80_H 201 DVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKI 280 (478) T ss_pred HHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHhc Confidence 33444 35777888877621 2567888899999999876555555543 688889998886 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 281 ~ 281 (478) T 5D80_H 281 T 281 (478) T ss_pred c Confidence 4 No 112 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=97.29 E-value=1.9e-07 Score=95.60 Aligned_cols=138 Identities=25% Similarity=0.275 Sum_probs=87.6 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR--SPNQNVQQAAAGALRNLVFRSTTN- 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~--s~d~eVr~~AL~aLs~La~~~~~~- 321 (747) .+++.+...+.+.+..++..++.++..++.........+...+.++.+...+. ..++.++..++.++..++...... T Consensus 266 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~ 345 (529) T 1JDH_A 266 GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAE 345 (529) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTHHHHHHHHHHHHTTCHHHHHHHHHHHHHHTSSSTTHH T ss_pred hHHHHHHHHhCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCHHHHHHHHHHhcCCChHhHHHHHHHHHHHhcCcccHH Confidence 44555666666667778888888888887654433333344556666766554 345677888888888887654321 Q NP_000290.2 322 --KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIP 382 (747) Q Consensus 322 --~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~ 382 (747) .......+.++.+...+....++.++..++.++.+++........+.. ++++.|..++... T Consensus 346 ~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~ 409 (529) T 1JDH_A 346 MAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRA 409 (529) T ss_dssp HHHHHHHHTTCHHHHHHTTSTTCCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHHHHHHHHH T ss_pred HHHHHHHhcccHHHHHHHHCCCCCHHHHHHHHHHHHHHhcChhhhHHHHhcCHHHHHHHHHHhc Confidence 112222356667777775223567888899999988876444444444 6777777777643 No 113 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=97.28 E-value=2.2e-07 Score=105.08 Aligned_cols=353 Identities=20% Similarity=0.229 Sum_probs=182.2 Template_Neff=10.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+..++.+.+..++..++.+|..++.........+...+++..++.++... +..++..++.+|..+..... ... T Consensus 276 ~~~~~L~~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~-~~~ 354 (780) T 2Z6G_A 276 GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS-NKP 354 (780) T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHhCCHH-HHH Confidence 3455566666666778888888888888764443333333445677777777654 56777888888888775432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..+..++..++.+|..++...... ....++++.|+.++... ++++. T Consensus 355 ~~~~~~~l~~L~~~l~-~~~~~v~~~al~~L~~l~~~~~~~-~~~~~~l~~L~~~l~~~----------------~~~v~ 416 (780) T 2Z6G_A 355 AIVEAGGMQALGLHLT-DPSQRLVQNCLWTLRNLSDAATKQ-EGMEGLLGTLVQLLGSD----------------DINVV 416 (780) T ss_pred HHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCCCCH-HHHcChHHHHHHHhcCC----------------CHHHH Confidence 2333456777777776 556778888999998887643321 11125566666666421 23344 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-..- .+. .+. .-.-.+.++.|...+.. ..-+..-.+.+.+.|.++. T Consensus 417 ~~a~~~L~~l~~~------~~~--------------~~~-~~~~~~~l~~L~~~l~~----~~~~~~v~~~a~~~L~~l~ 471 (780) T 2Z6G_A 417 TCAAGILSNLTCN------NYK--------------NKM-MVCQVGGIEALVRTVLR----AGDREDITEPAICALRHLT 471 (780) T ss_pred HHHHHHHHHHHcC------CHH--------------HHH-HHHHCChHHHHHHHHhc----CCCCHHHHHHHHHHHHHHH Confidence 4444443221100 000 000 00012233333322211 0112233456666666666 Q NP_000290.2 484 YRLDAEV------------PTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRT 551 (747) Q Consensus 484 ~~~~~~~------------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~ 551 (747) .+..... +.-.+-+.. ..+....+....++.+-.. .......+.+.++++. T Consensus 472 ~~~~~~~~~~~~~~~~~~i~~L~~ll~~-~~~~~v~~~a~~~L~~l~~----------------~~~~~~~~~~~~~l~~ 534 (780) T 2Z6G_A 472 SRHQDAEMAQNAVRLHYGLPVVVKLLHP-PSHWPLIKATVGLIRNLAL----------------CPANHAPLREQGAIPR 534 (780) T ss_pred cCCccHHHHHHHHHHCCcHHHHHHHhcC-CCCHHHHHHHHHHHHHHhc----------------CHHHHHHHHhCChHHH Confidence 5442110 000000000 0000000011111111100 0011112345566666 Q NP_000290.2 552 YLNLMGKSKK----------------------DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS 609 (747) Q Consensus 552 LL~LL~ss~d----------------------~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~ 609 (747) |+.++.. .. ..++..++.+|.+++.... ....+...++++.|+.++.+.++ T Consensus 535 L~~ll~~-~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~aL~~L~~~~~------~~~~~~~~~~l~~L~~~l~~~~~ 607 (780) T 2Z6G_A 535 LVQLLVR-AHQDTQRRTSMGGTQQQFVEGVRMEEIVEACTGALHILARDIH------NRIVIRGLNTIPLFVQLLYSPIE 607 (780) T ss_pred HHHHhcC-CCHHHHHHHHhhhhhhhhhcCCChHHHHHHHHHHHHHHhCChh------HHHHHHhCCcHHHHHHHhcCCCH Confidence 7666652 22 2366777777777775422 12222345667777777777677 Q NP_000290.2 610 DVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 610 eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .++..++.+|.+++..... ..+...++++.|..++.+ .++.++..++.+|.+|+.. T Consensus 608 ~v~~~a~~~L~~l~~~~~~~~~~~~~~~i~~L~~ll~~------~~~~v~~~a~~~L~~L~~~ 664 (780) T 2Z6G_A 608 NIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHS------RNEGVATYAAAVLFRMSED 664 (780) T ss_pred HHHHHHHHHHHHHhcCHHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHCC Confidence 7788888888888755332 233345566777777665 3567777788888887764 No 114 >1HO8_A VACUOLAR ATP SYNTHASE SUBUNIT H; HEAT repeat, HYDROLASE; 2.95A {Saccharomyces cerevisiae} SCOP: a.118.1.9 Probab=97.27 E-value=2.5e-07 Score=100.53 Aligned_cols=135 Identities=14% Similarity=0.099 Sum_probs=89.8 Template_Neff=8.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ..++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... .. T Consensus 125 ~~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~lv~~L~~~~~~~~~~~a~~~L~~L~~~~-~~ 201 (480) T 1HO8_A 125 QLEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EY 201 (480) T ss_dssp HHHHHHHHCSCS-SHHHHHHHHHHHHHHHTST-TTCCHHHHHHHHHCHHHHHHHHCTTCHHHHHHHHHHHHHHHTSH-HH T ss_pred hHHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhcccCccHHHHHHHHHHHHcCCh-HH Confidence 345666777766 6677888888888887643 22112223456776 7777753 35667888899998888643 33 Q NP_000290.2 322 KLETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVI 380 (747) Q Consensus 322 ~~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~ 380 (747) ...+.. .+.++.|+.++... .++.++..++.++..|.........+.. ++++.|+++++ T Consensus 202 r~~~~~~~~~~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~i~~~~~~~i~~Lv~ll~ 281 (480) T 1HO8_A 202 RDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVK 281 (480) T ss_dssp HHHHHTTHHHHHHHHHHHHHHHHC-------------CCHHHHHHHHHHHHHHHTTSHHHHHHHHTTSHHHHHHHHHHHH T ss_pred HHHHHHccccchHHHHHHHHhccccchhcchhhccCcCCCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHh Confidence 333444 35677787777621 2567888899999998876555555543 68888999888 Q NP_000290.2 381 IP 382 (747) Q Consensus 381 ~~ 382 (747) .. T Consensus 282 ~~ 283 (480) T 1HO8_A 282 IT 283 (480) T ss_dssp HC T ss_pred hc Confidence 64 No 115 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=97.21 E-value=2.9e-07 Score=88.31 Aligned_cols=135 Identities=25% Similarity=0.275 Sum_probs=88.9 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..+..........+...++++.+...+...++.++..++.++..++.......... T Consensus 173 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 252 (344) T 6S9O_F 173 ALPALVQLLSSPNEQILQLALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 252 (344) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCChHHHHHHHhcChHHHHHHHccCCCHHHHHHHHHHHHHHHcCcHHHHHHH Confidence 45556666666677888889999988876543333333334567777777777777888889999988875544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVII 381 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~ 381 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|..++.. T Consensus 253 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 309 (344) T 6S9O_F 253 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSH 309 (344) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhhC Confidence 34456777777776 55677888899999988865322 222222 566666666643 No 116 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=97.20 E-value=3.2e-07 Score=93.10 Aligned_cols=114 Identities=15% Similarity=0.165 Sum_probs=77.3 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP------NQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~------d~eVr~~AL~aLs~La~~~~ 319 (747) +++.+..++.+.++.++..++.+|.+++... .....+ ...+++.+..++... +..++..++.++.+++...+ T Consensus 332 ~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~-~~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~~a~~~L~~l~~~~~ 409 (457) T 1XM9_A 332 GLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LLHRVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 409 (457) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSG-GGHHHH-HHHTHHHHHHTTTSCCSCSTTHHHHHHHHHHHHHHHHTTCT T ss_pred hHHHHHHHHhcCCHHHHHHHHHHHHHHhcCH-HHHHHH-HcccHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhcCH Confidence 4556666676677788889999999988542 222222 234667777777655 57788888999988875444 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) .....+...+.++.+..++....++.++..++.++..++... T Consensus 410 ~~~~~~~~~~~~~~l~~ll~~~~~~~v~~~a~~~L~~l~~~~ 451 (457) T 1XM9_A 410 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 451 (457) T ss_dssp HHHHHHCCHHHHHHHHHHHHCTTCHHHHHHHHHHHHTTSSST T ss_pred HHHHHHHhccHHHHHHHHHhCCCCHHHHHHHHHHHHHHhhcH Confidence 444444455677778887762256778888888888887644 No 117 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=97.20 E-value=3.3e-07 Score=87.92 Aligned_cols=134 Identities=22% Similarity=0.180 Sum_probs=90.6 Template_Neff=11.900 Q NP_000290.2 246 TIPKAVQ-YLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~-lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.++. ++.+.+..++..++.++.+++.........+...++++.+..++... +..++..++.++.+++........ T Consensus 66 ~i~~l~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 145 (280) T 1XQS_B 66 GMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLL 145 (280) T ss_dssp HHHHCCCCCTSCSCHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHHHHHHSCSCHHHHHHHHHHHHHTTSSCHHHHH T ss_pred cHHHHHHHHhhcCCHHHHHHHHHHHHHHccCCHHHHHHHHHCCHHHHHHHHhccCCCHHHHHHHHHHHHHHHhcCHHHHH Confidence 3455555 66666677888899999998865444344444456777788877765 677888899999998865443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) .+...+.++.+..++. ..+..++..++.++.+++.... ....+.. ++++.|+.++. T Consensus 146 ~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 203 (280) T 1XQS_B 146 QFLRLDGFSVLMRAMQ-QQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVR 203 (280) T ss_dssp HHHTTTHHHHHHHHHT-SSCHHHHHHHHHHHHHHHHHCGGGHHHHHTTTHHHHHHHHHT T ss_pred HHHHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHHc Confidence 3444466777777776 4566788889999998887543 3333333 67777777764 No 118 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=97.18 E-value=3.4e-07 Score=83.37 Aligned_cols=134 Identities=19% Similarity=0.243 Sum_probs=88.0 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (243) T 5MFI_B 47 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 126 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTSSSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666766777888889999998886544433334445677778888877777888889999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (243) T 5MFI_B 127 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLD 182 (243) T ss_dssp HHTTCHHHHHHTTT-SSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHcc Confidence 44456777777776 5566778888888888876322 2222222 45666665554 No 119 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=97.18 E-value=3.4e-07 Score=83.37 Aligned_cols=134 Identities=19% Similarity=0.243 Sum_probs=87.2 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (243) T 5MFJ_B 47 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 126 (243) T ss_dssp CHHHHHHGGGCSCTTTC-CHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666766777888889999998886544433334445677778888877777888889999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (243) T 5MFJ_B 127 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLD 182 (243) T ss_dssp HHTTCHHHHHHTTT-SSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHcc Confidence 44456777777776 5566778888888888876322 2222222 45666665554 No 120 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=97.16 E-value=3.9e-07 Score=91.03 Aligned_cols=134 Identities=25% Similarity=0.292 Sum_probs=90.1 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+..++...++.++..++.++.+++.........+ T Consensus 200 ~i~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 279 (397) T 6SA6_A 200 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 279 (397) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHcCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHH Confidence 45566667776777888899999999887544444444455678888888887788889999999999876443333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 280 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 335 (397) T 6SA6_A 280 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 335 (397) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HhCChHHHHHHHhc-CCcHHHHHHHHHHHHHHhcCcHHHHHHHHhcChHHHHHHHhc Confidence 34456777777776 45667778888888888654322 222222 56666666654 No 121 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=97.16 E-value=4e-07 Score=98.84 Aligned_cols=135 Identities=26% Similarity=0.299 Sum_probs=93.7 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...+.++.+...+.+.+..++..++.++..++......... T Consensus 220 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 299 (671) T 6SA8_A 220 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQA 299 (671) T ss_dssp THHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcHHHHH Confidence 34566667777777888999999999987654443334444567788888887777888899999999888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK-EELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~-~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+...+. ..++.++..++.++..++...... ..+.. ++++.|..++. T Consensus 300 ~~~~~~~~~L~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~~l~~~l~ 356 (671) T 6SA8_A 300 VIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 356 (671) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHhChHHHHHHHhc-CCcHHHHHHHHHHHHHHhcCCcHHHHHHHhcChHHHHHHHhc Confidence 444567778888886 556788889999999987643322 22333 66777777775 No 122 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=97.14 E-value=4.4e-07 Score=88.91 Aligned_cols=134 Identities=22% Similarity=0.180 Sum_probs=91.0 Template_Neff=11.300 Q NP_000290.2 246 TIPKAVQ-YLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~-lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.++. ++...++.++..++.+|.+++.........+...++++.+..++... +..++..++.++.+++........ T Consensus 82 ~~~~l~~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 161 (296) T 1XQR_A 82 GMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLL 161 (296) T ss_dssp HHHHCCCCCTTCSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 3455555 66666677888899999998865443334444456777788777765 677888999999999865443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) .+...+.++.+...+. ..+..++..++.++.+++.... ....+.. ++++.|+.++. T Consensus 162 ~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~ll~ 219 (296) T 1XQR_A 162 QFLRLDGFSVLMRAMQ-QQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVR 219 (296) T ss_dssp HHHHTTHHHHHHHHHH-SSCHHHHHHHHHHHHHHHHHCGGGHHHHHHTTHHHHHHHHHT T ss_pred HHHHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHHc Confidence 3444456777777776 4567788889999999887543 3333333 67777777764 No 123 >4UAD_A Importin alpha import adaptor, Influenza; importin karyopherin complex NLS, PROTEIN; 2.42A {Homo sapiens} Probab=97.13 E-value=4.5e-07 Score=91.78 Aligned_cols=368 Identities=15% Similarity=0.162 Sum_probs=225.0 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE--SAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~--~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~ 321 (747) .+++.+...+.+.++.++..++.+|..+..... .....+...++++.+...+.. .++.++..++.++..++...... T Consensus 23 ~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 102 (479) T 4UAD_A 23 VITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQ 102 (479) T ss_dssp CCCHHHHHHHTSSCHHHHHHHHHHHHHHHTCSSSCCHHHHHHSTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCCCChhHhhcCcchHHHHHHHhhcCCCHHHHHHHHHHHHHHhCCCchH Confidence 456666777777778889999999988876422 111122223567777777765 66778888999998887654333 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|+.++... .+ T Consensus 103 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~ 166 (479) T 4UAD_A 103 TKIVIEAGAVPIFIELLN-SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKS---------------TR 166 (479) T ss_dssp HHHHHHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHC---------------CC T ss_pred HHHHHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHHHHHHhCCcHHHHHHHhhcC---------------Cc Confidence 333333457777788776 5567888899999998887533 2223333 5666666666521 12 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++-..+..+|..-.. ............+.++.|...+.. -+..-...+...| T Consensus 167 ~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l 219 (479) T 4UAD_A 167 LTMTRNAVWALSNLCR---------------------GKNPPPEFAKVSPCLPVLSRLLFS------SDSDLLADACWAL 219 (479) T ss_dssp HHHHHHHHHHHHHHHC---------------------CCSSCCCGGGTGGGHHHHHHHTTC------CCHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHc---------------------CCCCCchhhcccchHHHHHHHhcC------CCHHHHHHHHHHH Confidence 3333333333321110 000011111122334433333321 1111222233333 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++.... ......+.+.++++.++.++. + T Consensus 220 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 248 (479) T 4UAD_A 220 SYLSDGP--------------------------------------------------NEKIQAVIDSGVCRRLVELLM-H 248 (479) T ss_dssp HHHTSSS--------------------------------------------------HHHHHHHHHTTCHHHHHHGGG-C T ss_pred HHHhcCc--------------------------------------------------hHHHHHHHhCCHHHHHHHHhc-C Confidence 3322100 000111234567788888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI 637 (747) .++.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++... .. ..+...+++ T Consensus 249 ~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 323 (479) T 4UAD_A 249 NDYKVASPALRAVGNIVTGDDI-----QTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIF 323 (479) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCH T ss_pred CCHHhHHHHHHHHHHHhcCCHH-----HHHHHHhcChHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHH Confidence 6778888999999998875332 1223334578888999998888889999999999998763 22 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++...+ T Consensus 324 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 396 (479) T 4UAD_A 324 PVLIEILQK------AEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVM-DSKIVQVALNGLENILRLGE 396 (479) T ss_dssp HHHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHGGGGCS-CHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhc------cCHHHHHHHHHHHHHHHcCCCHHHHHHHHHcCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999864 233444455556788888888866 78889999999999987654 Q NP_000290.2 717 LQ 718 (747) Q Consensus 717 ~~ 718 (747) .. T Consensus 397 ~~ 398 (479) T 4UAD_A 397 QE 398 (479) T ss_dssp HH T ss_pred Hh Confidence 43 No 124 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=97.07 E-value=6.1e-07 Score=84.84 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=75.6 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..+........... T Consensus 89 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 168 (328) T 5MFD_C 89 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 168 (328) T ss_dssp HHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888999988876543333333344567777777777777888889999988875443332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..+..++..++.++..++.. T Consensus 169 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 202 (328) T 5MFD_C 169 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 202 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTS T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33456666777775 45566777777777777653 No 125 >6HB3_B Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 3.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.07 E-value=7e-07 Score=92.28 Aligned_cols=121 Identities=9% Similarity=-0.026 Sum_probs=77.4 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSS---QDEKYQAIGAYYIQHTCFQDESAKQQVY--QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 246 iL~~Ll~lL~s---sd~eVr~sAL~aLsnLs~~~~~~~~~li--~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~ 320 (747) .++.|+.++.. .+..++..++.+|.++... ......+. ..+.++.++.++...+..++..++.+|.+++.... T Consensus 52 ~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~-~~~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl~~~~~- 129 (369) T 6HB3_B 52 PIKDIIKMIMDPEHGTRVIIQQGVTILVNLSED-KLVRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNLAKDDG- 129 (369) T ss_pred cHHHHHHHHhCCCCCCHHHHHHHHHHHHHHcCC-HHHHHHHHhccCCcHHHHHHHhcCCCHHHHHHHHHHHHHHcCChH- Confidence 56667777743 3567888899999998754 33344444 56788888888877667788888999988886432 Q NP_000290.2 321 NKLET-------------------------RRQNGIREAVSLLRRTG------NAEIQKQLTGLLWNLSSTDELKEELIA 369 (747) Q Consensus 321 ~~~~l-------------------------l~~~IL~~Ll~lL~ss~------d~eVr~~AL~aLsnLas~~~~~~~Lve 369 (747) ....+ ...++++.++.++. .. +..++..++.+|.+++........+.+ T Consensus 130 ~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~-~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~l~~ 208 (369) T 6HB3_B 130 ILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFV-KGYDKKLTKYASFNYLAFFFADISRFKLGRMYFIE 208 (369) T ss_pred HHHHHHhcCCCCCCHHHHHHHHHHHHHHHHHHCCcHHHHHHHhc-CCCCccCCCHHHHHHHHHHHHHHcCCHHHHHHHHH Confidence 11212 11345666666665 32 345666777777777765444444444 No 126 >3OPB_A SWI5-dependent HO expression protein 4; HEAT and ARM fold, Myosin; 2.9A {Saccharomyces cerevisiae} Probab=97.06 E-value=7.2e-07 Score=100.91 Aligned_cols=156 Identities=12% Similarity=0.164 Sum_probs=96.5 Template_Neff=10.500 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKE------KGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~------giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) .++++.|+.++. +.+..++..++.+|.+++..... ....+.+. ++++.|+.++.+.++.++..++++| T Consensus 605 ~~~~~~L~~ll~-~~~~~v~~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~~~~l~~L~~ll~~~~~~v~~~a~~~L 678 (778) T 3OPB_A 605 KVYWSTIENLML-DENVPLQRSTLELISNMMSHPLT-----IAAKFFNLENPQSLRNFNILVKLLQLSDVESQRAVAAIF 678 (778) T ss_dssp HHHHHHHHHGGG-CSSHHHHHHHHHHHHHHHTSGGG-----TGGGTSCCSSHHHHHHHHHHHHGGGCSCHHHHHHHHHHH T ss_pred ccHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcChhH-----HHHHhcCCCChhHHHhHHHHHHHhcCCCHHHHHHHHHHH Confidence 356777777776 35677788888888888864321 12222332 6778888888777778888888888 Q NP_000290.2 620 SNMSRH-PLL-HRVMG-NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----K-QYFS-SSMLNNIIN 690 (747) Q Consensus 620 snLa~~-~e~-~~ll~-~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~-~Lve-~giL~~Ll~ 690 (747) ++++.. +.. ...+. .++++.|+.++.+.. .+..++..++++|.+++...+... . .+.+ .++++.|.. T Consensus 679 ~~l~~~~~~~~~~l~~~~~~i~~L~~~L~~~~----~~~~l~~~a~~aL~~L~~~~~~~~~~~~~~~l~~~~~~~~~L~~ 754 (778) T 3OPB_A 679 ANIATTIPLIAKELLTKKELIENAIQVFADQI----DDIELRQRLLMLFFGLFEVIPDNGTNEVYPLLQENQKLKDALNM 754 (778) T ss_dssp HHHHHHCHHHHHHHTTCHHHHHHHHHHHHHTT----TCHHHHHHHHHHHHHHHTTCCSTTTTSCCHHHHSCHHHHHHHHH T ss_pred HHHHccCHHHHHHHhcCccHHHHHHHHHHhCC----CCHHHHHHHHHHHHHHHhhCCcCCCccchhHHhcCHHHHHHHHH Confidence 888755 222 23332 567777777776510 145678888888888886533222 0 1222 256777777 Q NP_000290.2 691 LCRSSA-SPKAAEAARLLLSDM 711 (747) Q Consensus 691 LL~s~~-d~eVr~aAL~aLsnL 711 (747) ++.... ++.++..+..+|.++ T Consensus 755 ~l~~~~~~~~~~~~~~~~L~~l 776 (778) T 3OPB_A 755 SLKRGDSGPEFSAAIPVILAKI 776 (778) T ss_dssp HHSSSSSCSSTTSHHHHHHTTC T ss_pred HHhhCCCCHHHHHHHHHHHHhc Confidence 776431 335555566555543 No 127 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=97.02 E-value=7.7e-07 Score=80.85 Aligned_cols=113 Identities=29% Similarity=0.332 Sum_probs=76.4 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.........+. T Consensus 4 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 83 (252) T 4HXT_A 4 VEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIV 83 (252) T ss_dssp HHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHcCCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCHHHHHHHH Confidence 44556666667778888999999988765433333334446677777777777778888999999988765433333333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ..++++.+...+. ..++.++..++.++.+++.. T Consensus 84 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 116 (252) T 4HXT_A 84 DAGGVEVLVKLLT-STDSEVQKEAARALANIASG 116 (252) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HCChHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 3456667777775 45567777777887777653 No 128 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=97.01 E-value=9.1e-07 Score=98.43 Aligned_cols=136 Identities=15% Similarity=0.144 Sum_probs=91.1 Template_Neff=10.100 Q NP_000290.2 245 LTIPKAVQYLSS--QDEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQ 304 (747) Q Consensus 245 ~iL~~Ll~lL~s--sd~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr 304 (747) .+++.|+..+.. .+..+...++.+|..++..... ....+. ..+.++.++.++...+..++ T Consensus 60 ~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~~~~~~~ 139 (651) T 3GQ2_A 60 QAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVR 139 (651) T ss_dssp HHHHHHHHHHTTCTTCHHHHHHHHHHHHHHHCCSSSCC----------CHHHHHHHHHHTSHHHHHTHHHHTTCCCHHHH T ss_pred cHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCChHhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccCCCHHHH Confidence 456667777764 4567788888888888764332 112222 35667777777777777888 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKL-ETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~-~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.+|..++........ .+. ..+.+..++.++. ..+..++..++.+|.+++.. ......+.. ++++.|+.++. T Consensus 140 ~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~g~~~~L~~ll~ 218 (651) T 3GQ2_A 140 WPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIIT 218 (651) T ss_dssp HHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCChHHHHHHHHH Confidence 9999999988865432211 222 3456778888886 55677888999999999873 333333333 88888888886 Q NP_000290.2 381 I 381 (747) Q Consensus 381 ~ 381 (747) . T Consensus 219 ~ 219 (651) T 3GQ2_A 219 E 219 (651) T ss_dssp H T ss_pred H Confidence 4 No 129 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=97.01 E-value=9.1e-07 Score=98.43 Aligned_cols=136 Identities=15% Similarity=0.144 Sum_probs=90.5 Template_Neff=10.100 Q NP_000290.2 245 LTIPKAVQYLSS--QDEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQ 304 (747) Q Consensus 245 ~iL~~Ll~lL~s--sd~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr 304 (747) .+++.|+..+.. .+..+...++.+|..++..... ....+. ..+.++.++.++...+..++ T Consensus 60 ~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~~~~~~~ 139 (651) T 3GRL_A 60 QAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVR 139 (651) T ss_dssp CCHHHHHHHHHSCTTCHHHHHHHHHHHHHHHCCC--------------CHHHHHHHHHHHSTHHHHHHHHHTTCCCHHHH T ss_pred cHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCChHhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccCCCHHHH Confidence 456667777764 4567788888888888764332 112222 35667777777777777888 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKL-ETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~-~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.+|..++........ .+. ..+.+..++.++. ..+..++..++.+|.+++.. ......+.. ++++.|+.++. T Consensus 140 ~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~g~~~~L~~ll~ 218 (651) T 3GRL_A 140 WPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIIT 218 (651) T ss_dssp HHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCChHHHHHHHHH Confidence 9999999988865432211 222 3456778888886 55677888999999999873 333333333 88888888886 Q NP_000290.2 381 I 381 (747) Q Consensus 381 ~ 381 (747) . T Consensus 219 ~ 219 (651) T 3GRL_A 219 E 219 (651) T ss_dssp H T ss_pred H Confidence 4 No 130 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=97.01 E-value=8.1e-07 Score=80.69 Aligned_cols=114 Identities=27% Similarity=0.320 Sum_probs=76.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 45 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 124 (252) T 4HXT_A 45 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 124 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677888889999998876544333333444667777777777777888889999988876443332233 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 125 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 158 (252) T 4HXT_A 125 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASG 158 (252) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcC Confidence 33356666666665 45567777788888877764 No 131 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=97.00 E-value=8.3e-07 Score=82.05 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=75.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 44 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 123 (281) T 4PLS_B 44 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 123 (281) T ss_dssp HHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCcHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666777888889999998876443333333444577777777777777888888898888876433332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 124 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 157 (281) T 4PLS_B 124 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 157 (281) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 33456666777665 44566777777777776653 No 132 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=96.99 E-value=9.5e-07 Score=87.41 Aligned_cols=114 Identities=22% Similarity=0.254 Sum_probs=75.1 Template_Neff=12.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+..++.+.++.++..++.++.+++.. .......+...++++.+..++.. .+..++..++.+|.+++....... T Consensus 127 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 206 (354) T 5IZA_A 127 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 206 (354) T ss_dssp HHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChHhH Confidence 3455666677766778888999999998874 22223334445677778888776 677888889999999886533333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLa 358 (747) ..+.. .++++.+..++.. ..+..++..++.++..+. T Consensus 207 ~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~L~~l~ 246 (354) T 5IZA_A 207 ADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVS 246 (354) T ss_dssp HHHHTSTTHHHHHHHHTCSSCSSCCHHHHHHHHHHHHHHH T ss_pred HHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHHHHHHHH Confidence 33444 4667777777651 112456666777777765 No 133 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=96.97 E-value=1e-06 Score=87.19 Aligned_cols=113 Identities=22% Similarity=0.270 Sum_probs=74.6 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+..++.+.++.++..++.++.+++.. .......+...++++.+..++.. .+..++..++.+|.+++........ T Consensus 128 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 207 (354) T 5IZ8_A 128 CMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKA 207 (354) T ss_dssp HHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSCHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChHhHH Confidence 455666677666778888999999998874 22223334445677778888776 6778888899999998865333333 Q NP_000290.2 324 ETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLa 358 (747) .+.. .++++.+..++.. ..+..++..++.++..+. T Consensus 208 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~L~~l~ 246 (354) T 5IZ8_A 208 DICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVS 246 (354) T ss_dssp HHHTSTTHHHHHHHHTTCCCTTSCCHHHHHHHHHHHHHH T ss_pred HHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHHHHHHHH Confidence 3444 4667777777651 112456666777777765 No 134 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.96 E-value=1.1e-06 Score=90.60 Aligned_cols=135 Identities=25% Similarity=0.264 Sum_probs=91.1 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.+|.+++.........+...++++.+..++...++.++..++.+|..++.........+ T Consensus 342 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 421 (510) T 6SA7_B 342 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 421 (510) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 34445555556667788888888888876544433334445677788888877778888899999998875544433344 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVII 381 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~ 381 (747) ...++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|..++.. T Consensus 422 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 478 (510) T 6SA7_B 422 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSH 478 (510) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHcCcHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCchHHHHHHHCCHHHHHHHHhhc Confidence 44567778888886 5677889999999999985432 2222333 667777776653 No 135 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=96.95 E-value=1.1e-06 Score=80.29 Aligned_cols=135 Identities=24% Similarity=0.251 Sum_probs=89.9 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++......... T Consensus 92 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 171 (247) T 4V3Q_A 92 GALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQA 171 (247) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666667788888899998887654433333344567777888777777788888999998887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++. T Consensus 172 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 228 (247) T 4V3Q_A 172 VIDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQS 228 (247) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHHh Confidence 334456777777776 5567788889999998886532 2222333 66677776665 No 136 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=96.93 E-value=1.2e-06 Score=84.95 Aligned_cols=134 Identities=21% Similarity=0.263 Sum_probs=83.9 Template_Neff=12.500 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.+++.. .......+...++++.+..++.. .++.++..++.++.+++....... T Consensus 122 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 201 (339) T 5Z8H_A 122 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 201 (339) T ss_pred ChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCCHHHHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHH Confidence 3455666667666778888999999998874 22223334445677778887776 577788889999999886444333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSS----TDELKEELIA-DALPVLADRV 379 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas----~~~~~~~Lve-giLe~Lv~LL 379 (747) ..+.. .++++.+..++. ..+ ..++..++.++.++.. .......+.. ++++.++.++ T Consensus 202 ~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l 267 (339) T 5Z8H_A 202 ADICAVDGALAFLVGTLT-YRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHL 267 (339) T ss_pred HHHHHhcChHHHHHHHhc-CCCCCCCHHHHHHHHHHHHHHHHhhccCHHHHHHHHHCCHHHHHHHHH Confidence 34444 466777777775 222 5667777777777752 2222222222 5555555555 No 137 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=96.89 E-value=1.4e-06 Score=80.58 Aligned_cols=112 Identities=27% Similarity=0.322 Sum_probs=75.3 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 173 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 252 (286) T 5AEI_B 173 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 252 (286) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677788888999988876544333333344567777777777777888889999988885544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+...+. ..++.++..++.++..++ T Consensus 253 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 284 (286) T 5AEI_B 253 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 284 (286) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHH T ss_pred HHcCHHHHHHHHhh-CCCHHHHHHHHHHHHHHh Confidence 34456677777776 456677777877777664 No 138 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=96.88 E-value=1.5e-06 Score=85.84 Aligned_cols=124 Identities=24% Similarity=0.343 Sum_probs=84.2 Template_Neff=12.000 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) +..++..++.++.+++.........+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 97 ~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 176 (354) T 5IZA_A 97 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 176 (354) T ss_dssp HHHHHHHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHH T ss_pred CHHHHHHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHH Confidence 5677888888888887644333333333 46777888888777788889999999998864 222233344456777788 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA--DALPVLADRVII 381 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve--giLe~Lv~LL~~ 381 (747) .++....++.++..++.++.+++.. ......+.. ++++.|+.++.. T Consensus 177 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~ 225 (354) T 5IZA_A 177 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTY 225 (354) T ss_dssp HHHHHCCCHHHHHHHHHHHHHHHTTCHHHHHHHHTSTTHHHHHHHHTCS T ss_pred HHHHhcCCHHHHHHHHHHHHHHHcCChHhHHHHHhhccHHHHHHHHHhh Confidence 8876225677888899999999876 444434433 667777777664 No 139 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=96.88 E-value=1.6e-06 Score=85.78 Aligned_cols=124 Identities=24% Similarity=0.343 Sum_probs=84.2 Template_Neff=12.000 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) +..++..++.++.+++.........+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 97 ~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 176 (354) T 5IZ8_A 97 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 176 (354) T ss_dssp HHHHHHHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHH T ss_pred CHHHHHHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHH Confidence 5677888888888887644333333333 46777888888777788888999999998864 222233344456777788 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA--DALPVLADRVII 381 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve--giLe~Lv~LL~~ 381 (747) .++....++.++..++.+|.+++.. ......+.. ++++.|+.++.. T Consensus 177 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~ 225 (354) T 5IZ8_A 177 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTY 225 (354) T ss_dssp HHHHHCCSHHHHHHHHHHHHHHHTSCHHHHHHHHTSTTHHHHHHHHTTC T ss_pred HHHHhcCCHHHHHHHHHHHHHHHcCChHhHHHHHhhccHHHHHHHHHhh Confidence 8876225677888899999999876 444333433 667777777664 No 140 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=96.87 E-value=1.6e-06 Score=88.90 Aligned_cols=135 Identities=18% Similarity=0.233 Sum_probs=88.1 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLR----SPNQNVQQAAAGALRNLV---F 316 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~----s~d~eVr~~AL~aLs~La---~ 316 (747) +++.+..++. ..+..++..++.+|.+++...+.....+.. .++++.+..++. ..+..++..++.++.+++ . T Consensus 287 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~ 366 (458) T 3NMZ_A 287 SVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIA 366 (458) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhHHHHHHhcChHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhc Confidence 4555666665 456778888999999988743333333333 566777777765 224566777888887765 2 Q NP_000290.2 317 RSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS-TDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 317 ~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas-~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) ........+...++++.+..++. ..++.++..++.+|..++. .......+.. ++++.|..++.. T Consensus 367 ~~~~~~~~l~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~L~~ll~~ 432 (458) T 3NMZ_A 367 TNEDHRQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHS 432 (458) T ss_pred CCHHHHHHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhC Confidence 22223333344467777888886 5567889999999999987 3444444544 788888887754 No 141 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.87 E-value=1.6e-06 Score=89.20 Aligned_cols=134 Identities=26% Similarity=0.306 Sum_probs=91.2 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.+|.+++.........+...++++.+...+.+.++.++..++.+|..++.........+ T Consensus 300 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 379 (510) T 6SA7_B 300 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 379 (510) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHH Confidence 45566666666677888889999998876544333344445677778888877778888899999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.+|..++.... ....+.. ++++.|+.++. T Consensus 380 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 435 (510) T 6SA7_B 380 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 435 (510) T ss_dssp HHTTHHHHHHHHHT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhc Confidence 44467777887776 5577888889999998865432 2223333 66777777664 No 142 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=96.87 E-value=1.7e-06 Score=90.04 Aligned_cols=367 Identities=17% Similarity=0.192 Sum_probs=215.7 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+... ++.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 115 ~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 194 (521) T 5TBK_C 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194 (521) T ss_dssp HHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHHHHHHTTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 445555555543 6678888888888887654333333334467777888887777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++.......... .++++.+..++... ++++ T Consensus 195 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v 258 (521) T 5TBK_C 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT----------------DVNI 258 (521) T ss_dssp HHHTTCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTCS----------------CHHH T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHhhCC----------------CHHH Confidence 33445677777777533344678888888888876533221111 15566666665431 2334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... .+ ..++.+. -.+++..|...+.. .+..-...++..|.++ T Consensus 259 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l 311 (521) T 5TBK_C 259 LVDTVWALSYLTDA------GN--------------EQIQMVI-DSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 311 (521) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHHH-HTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcc------Ch--------------HHHHHHH-HCChHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33343333221100 00 0000000 02333434333321 0111112222223332 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|..++. +.++ T Consensus 312 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 340 (521) T 5TBK_C 312 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 340 (521) T ss_dssp HTSC--------------------------------------------------HHHHHHHHHTTCGGGHHHHHT-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHHhCCHHHhHHHHhh-CCCH Confidence 2110 000112234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 341 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~ 415 (521) T 5TBK_C 341 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415 (521) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCcHHHHHHHHHhCCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHH Confidence 8888999999999865332 223334557888888888887888999999999999864 2 11 22233467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) |..++.. .++.++..++.+|.+++...+... ..+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 416 L~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~L~~l~~~~ 488 (521) T 5TBK_C 416 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 488 (521) T ss_dssp HHGGGGS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHHHCSTT-CHHHHHHHHHHHHHHCCC- T ss_pred HHHHcCC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHHHHHHHHHhcCCC Confidence 8888765 367888899999999887533211 2233446778888888766 7889999999999999766 Q NP_000290.2 716 ELQ 718 (747) Q Consensus 716 ~~~ 718 (747) +.. T Consensus 489 ~~~ 491 (521) T 5TBK_C 489 DID 491 (521) T ss_dssp --- T ss_pred CCC Confidence 543 No 143 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=96.87 E-value=1.7e-06 Score=90.04 Aligned_cols=367 Identities=17% Similarity=0.192 Sum_probs=215.0 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+... ++.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 115 ~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 194 (521) T 5TBK_D 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194 (521) T ss_dssp HHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHHHHHHTTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 445555555543 6678888888888887654333333334467777888887777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++.......... .++++.+..++... ++++ T Consensus 195 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v 258 (521) T 5TBK_D 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT----------------DVNI 258 (521) T ss_dssp HHHTCCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTCS----------------CHHH T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHhhCC----------------CHHH Confidence 33445677777777533344678888888888876533221111 15566666665431 2334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... .+ ..++.+. -.+++..|...+.. .+..-...++..|.++ T Consensus 259 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l 311 (521) T 5TBK_D 259 LVDTVWALSYLTDA------GN--------------EQIQMVI-DSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 311 (521) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHHH-HTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcc------Ch--------------HHHHHHH-HCChHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33343333221100 00 0000000 02333434333321 0111112222223332 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|..++. +.++ T Consensus 312 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 340 (521) T 5TBK_D 312 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 340 (521) T ss_dssp HTSC--------------------------------------------------HHHHHHHHHTTCGGGHHHHHH-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHHhCCHHHhHHHHhh-CCCH Confidence 2110 000112234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 341 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~ 415 (521) T 5TBK_D 341 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415 (521) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCcHHHHHHHHHhCCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHH Confidence 8888999999999865332 223334557888888888887888999999999999864 2 11 22233467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) |..++.. .++.++..++.+|.+++...+... ..+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 416 L~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~L~~l~~~~ 488 (521) T 5TBK_D 416 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 488 (521) T ss_dssp HHGGGGS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHCC-- T ss_pred HHHHcCC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHHHHHHHHHhcCCC Confidence 8888765 367888899999999887533211 2233446778888888766 7889999999999999766 Q NP_000290.2 716 ELQ 718 (747) Q Consensus 716 ~~~ 718 (747) +.. T Consensus 489 ~~~ 491 (521) T 5TBK_D 489 DID 491 (521) T ss_dssp --- T ss_pred CCC Confidence 543 No 144 >6HB1_A Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 2.33A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.86 E-value=1.8e-06 Score=89.00 Aligned_cols=169 Identities=9% Similarity=0.050 Sum_probs=120.8 Template_Neff=10.100 Q NP_000290.2 547 DAIRTYLNLMGK--SKKDATLEACAGALQNLTASKGLMSSGMSQLIGL--KEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 547 G~I~~LL~LL~s--s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli--e~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ++++.|+.++.. +.++.++..++++|.+++.... ....+. +.++++.|+.++.+.+..++..++++|.++ T Consensus 51 ~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~------~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl 124 (369) T 6HB1_A 51 RPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL------VRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNL 124 (369) T ss_dssp HHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH------HHHCCCCCSTHHHHHHHHHHHCTTCTTHHHHHHHHHHH T ss_pred hHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH------HHHHHhhcChHHHHHHHHHHHcCCCccHHHHHHHHHHH Confidence 588999999952 1356788899999999986532 244445 689999999999887778889999999999 Q NP_000290.2 623 SRHPLLH-RV-------------------------MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA 676 (747) Q Consensus 623 a~~~e~~-~l-------------------------l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~ 676 (747) +...... .+ ...++++.|+.++.........++.++..++++|.+|+.. +..+ T Consensus 125 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~ 203 (369) T 6HB1_A 125 AKDDGILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFVKGYDKKLTKYASFNYLAFFFADISRF-KLGR 203 (369) T ss_dssp TTSGGGGGGGGCBCSCSSSEEETTEEECCCCTTTCCCSBHHHHHHHHHHHCGGGSSCSSCCCTTHHHHHHHHTTS-HHHH T ss_pred ccChhHHHHHhhcCCCCCCchhhhHHHHHHcHHHHHHhhHHHHHHHHHhhcCcccCCchhchHHHHHHHHHHcCC-HHHH Confidence 9864332 22 1246778888887652000000456788899999999875 5666 Q NP_000290.2 677 KQYFSSS------MLNNIINLCR-SSASPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 677 ~~Lve~g------iL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ..+.+.+ .+..++.++. +. +..++..++.+|.+++.+.+....+.. T Consensus 204 ~~l~~~g~~~~~~~l~~ll~~l~~~~-~~~~~~~a~~~L~nl~~~~~~~~~i~~ 256 (369) T 6HB1_A 204 MYFIEEQEYDGVVPISKLLVFTEKYD-AKVRREGVASTIKNSLFDSETHERLLK 256 (369) T ss_dssp HHHHSCCTTTCCCGGGGTGGGGGCTT-CHHHHHHHHHHHHHHTCCGGGHHHHHH T ss_pred HHHhhcccccCcccHHHHHHHhcccC-CHHHHHHHHHHHHHHhcCHHHHHHHhc Confidence 6677766 4666666665 34 678899999999999988775544443 No 145 >6HB2_D Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; HET: MSE; 2.7A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.86 E-value=1.8e-06 Score=89.00 Aligned_cols=169 Identities=9% Similarity=0.050 Sum_probs=120.8 Template_Neff=10.100 Q NP_000290.2 547 DAIRTYLNLMGK--SKKDATLEACAGALQNLTASKGLMSSGMSQLIGL--KEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 547 G~I~~LL~LL~s--s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli--e~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ++++.|+.++.. +.++.++..++++|.+++.... ....+. +.++++.|+.++.+.+..++..++++|.++ T Consensus 51 ~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~------~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl 124 (369) T 6HB2_D 51 RPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL------VRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNL 124 (369) T ss_dssp HHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH------HHHCCCCCCTHHHHHHHHHHSCTTCTTHHHHHHHHHHH T ss_pred hHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH------HHHHHhhcChHHHHHHHHHHHcCCCccHHHHHHHHHHH Confidence 588999999952 1356788899999999986532 244445 689999999999887778889999999999 Q NP_000290.2 623 SRHPLLH-RV-------------------------MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA 676 (747) Q Consensus 623 a~~~e~~-~l-------------------------l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~ 676 (747) +...... .+ ...++++.|+.++.........++.++..++++|.+|+.. +..+ T Consensus 125 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~ 203 (369) T 6HB2_D 125 AKDDGILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFVKGYDKKLTKYASFNYLAFFFADISRF-KLGR 203 (369) T ss_dssp TTSGGGGGGGGCBCSCSSSEEETTEEECCCCTTTCCCSBHHHHHHHHHHHHGGGSSCSSCCCTTHHHHHHHHTTS-HHHH T ss_pred ccChhHHHHHhhcCCCCCCchhhhHHHHHHcHHHHHHhhHHHHHHHHHhhcCcccCCchhchHHHHHHHHHHcCC-HHHH Confidence 9864332 22 1246778888887652000000456788899999999875 5666 Q NP_000290.2 677 KQYFSSS------MLNNIINLCR-SSASPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 677 ~~Lve~g------iL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ..+.+.+ .+..++.++. +. +..++..++.+|.+++.+.+....+.. T Consensus 204 ~~l~~~g~~~~~~~l~~ll~~l~~~~-~~~~~~~a~~~L~nl~~~~~~~~~i~~ 256 (369) T 6HB2_D 204 MYFIEEQEYDGVVPISKLLVFTEKYD-AKVRREGVASTIKNSLFDSETHERLLK 256 (369) T ss_dssp HHHHSCCTTTCSCTHHHHGGGGGCTT-CHHHHHHHHHHHHHHTCSGGGHHHHHH T ss_pred HHHhhcccccCcccHHHHHHHhcccC-CHHHHHHHHHHHHHHhcCHHHHHHHhc Confidence 6677766 4666666665 34 678899999999999988775544443 No 146 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=96.84 E-value=1.8e-06 Score=81.45 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=77.1 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..+..........+ T Consensus 47 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 126 (328) T 5MFD_C 47 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 126 (328) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHhhcCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777777888899999988876543333333344567777777777777888889999988876533333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..+... T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 160 (328) T 5MFD_C 127 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 160 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33456667777775 45667777788888777653 No 147 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.84 E-value=1.8e-06 Score=88.77 Aligned_cols=115 Identities=27% Similarity=0.318 Sum_probs=78.7 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.+|..++.........+...++++.+..++.+.++.++..++.++..++.........+ T Consensus 384 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 463 (510) T 6SA7_B 384 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 463 (510) T ss_dssp HHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCchHHHHH Confidence 34445555555667778888888888865544433344445677888888887788889999999999985544433333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) ...++++.+..++. +.++.++..++.++..+.... T Consensus 464 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~ 498 (510) T 6SA7_B 464 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLGSGG 498 (510) T ss_dssp HHTTHHHHHHHGGG-CSSHHHHHHHHHHHHHHTC-- T ss_pred HHCCHHHHHHHHhh-ccchHHHHHHHHHHHHHhhcc Confidence 34456777777776 556788888999888887643 No 148 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=96.77 E-value=2.5e-06 Score=81.50 Aligned_cols=115 Identities=28% Similarity=0.317 Sum_probs=77.6 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 46 ~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 125 (344) T 6S9O_F 46 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALRNIASGGNEQIQA 125 (344) T ss_dssp TCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHSCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred ChHHHHHHHcCCCCHHHHHHHHHHHHHHhcCChhHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCchHHHH Confidence 34556666677777788889999999887654333333334456777777777777788888999998887643333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+. ..++.++..++.++..++.. T Consensus 126 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 160 (344) T 6S9O_F 126 VIDAGALPALVQLLS-SPNEQILSSALGALSNIASG 160 (344) T ss_dssp HHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTS T ss_pred HHhCCHHHHHHHHhc-CCcHHHHHHHHHHHHHHHcC Confidence 333456677777775 45667777888888877653 No 149 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=96.77 E-value=2.5e-06 Score=86.12 Aligned_cols=167 Identities=15% Similarity=0.182 Sum_probs=108.5 Template_Neff=12.600 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL----------------QS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL----------------~s 606 (747) +++.++++.|+.++....++.++..++.+|.+++.... ....+. .++++.|+.++ .. T Consensus 82 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~------~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~~ 154 (457) T 1XM9_A 82 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE------LKEELI-ADALPVLADRVIIPFSGWCDGNSNMSREV 154 (457) T ss_dssp HHHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSSS------THHHHH-HHHHHHCCCCCCHHHHTCC---------C T ss_pred HHhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCHH------HHHHHH-cchHHHHHHHhccccCCCCCCCCCccccc Confidence 45677888888888633566788889999999987422 123333 57888888888 56 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHPLL-HRVMG-NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP----------- 673 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~e~-~~ll~-~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~----------- 673 (747) .++.++..++++|.+++..... ..+.. .++++.++.++.........+..++..++.+|.+++...+ T Consensus 155 ~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~ 234 (457) T 1XM9_A 155 VDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLE 234 (457) T ss_dssp CCHHHHHHHHHHHHHHTTSHHHHHHHTTSTTHHHHHHHHHHHHHHHTCTTCTTHHHHHHHHHHHTTTHHHHSCCHHHHHH T ss_pred CCHHHHHHHHHHHHHHccChHHHHHHHhcccHHHHHHHHHHHhhhcCcCCHHHHHHHHHHHHHHhcccccCCCcchhhhh Confidence 6788899999999999976433 22332 3567777777764100000256788889999999886311 Q NP_000290.2 674 ---------------------------------------QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 674 ---------------------------------------e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .....+...++++.++.++....+..++..++.+|.+++.. T Consensus 235 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~ 314 (457) T 1XM9_A 235 YNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTAS 314 (457) T ss_dssp HTC----------------------------CCCCCSSCCGGGGGGSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTC T ss_pred hcccccccccccccccCcccchhccccccCCCCcccCCCchhHHhhchhHHHHHHHHhccCCCHHHHHHHHHHHHHHHhc Confidence 11122334456667777766532556677788888887765 Q NP_000290.2 715 KE 716 (747) Q Consensus 715 ~~ 716 (747) .+ T Consensus 315 ~~ 316 (457) T 1XM9_A 315 KG 316 (457) T ss_dssp SS T ss_pred cc Confidence 54 No 150 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=96.77 E-value=2.5e-06 Score=77.32 Aligned_cols=114 Identities=27% Similarity=0.311 Sum_probs=76.9 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 129 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 208 (252) T 4HXT_A 129 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPTSAIKAI 208 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSBHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 34555555666667788888888888876543333333344567777777777777888889999988886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++.+++.. T Consensus 209 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~ 242 (252) T 4HXT_A 209 VDAGGVEVLQKLLT-STDSEVQKEAQRALENIKSG 242 (252) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHHT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33356777777776 45677888888888888764 No 151 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=96.73 E-value=3e-06 Score=84.23 Aligned_cols=132 Identities=23% Similarity=0.240 Sum_probs=87.4 Template_Neff=12.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR 327 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~ 327 (747) ..++..+.+.+..++..++.++.+++.........+...++++.+..++.+.++.++..++.++.+++.........+.. T Consensus 160 ~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~ 239 (397) T 6SA6_A 160 AALVLKLNANDDQIIQEALWKLGNHASGGNLRIQWVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVID 239 (397) T ss_dssp HHHHHHTTCSCHHHHHHHHHHHHHHHTTTHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHH T ss_pred HHHHHHccCCCHHHHHHHHHHHHHHhhCCchHHHHHHHCCcHHHHHHHcCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHH Confidence 34445555567788889999999988755444444445567788888888777788889999999988654443334444 Q NP_000290.2 328 QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 328 ~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++++.+..++. ..++.++..++.++.+++..... ...+.. ++++.|+.+|. T Consensus 240 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 293 (397) T 6SA6_A 240 AGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 293 (397) T ss_dssp TTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred CCcHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCcHHHHHHHHhCChHHHHHHHhc Confidence 567777888876 55677888888888888654222 222222 45555555543 No 152 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=96.71 E-value=3.3e-06 Score=86.51 Aligned_cols=135 Identities=22% Similarity=0.327 Sum_probs=88.0 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQ-----------DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRN 313 (747) Q Consensus 246 iL~~Ll~lL~ss-----------d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~ 313 (747) +++.+..++... +..++..++.+|.+++.........+.. .++++.+..++...+..++..++.++.+ T Consensus 190 ~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~ 269 (458) T 3NMZ_A 190 GLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN 269 (458) T ss_pred hHHHHHHHHhccccCCCCCCCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhCCcHHHHHHHhcCCCHHHHHHHHHHHHH Confidence 445555555543 5678888999999988754433332333 4677888888877778889999999999 Q NP_000290.2 314 LVFRST-TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELI--ADALPVLADRVI 380 (747) Q Consensus 314 La~~~~-~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lv--egiLe~Lv~LL~ 380 (747) ++.... .....+...++++.+..++....+..++..++.++.+++.. ......+. .++++.|+.++. T Consensus 270 l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 340 (458) T 3NMZ_A 270 LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLT 340 (458) T ss_pred HHCCCChhHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhHHHHHHhcChHHHHHHHHc Confidence 886543 22333444457777777775234567888889999998873 33333333 256666666654 No 153 >6HB1_A Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 2.33A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.61 E-value=5.3e-06 Score=85.37 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...++.++..++.++.++..... ...+... +.++.|+.++.. ..++.++..++.+|.+++.... T Consensus 9 ~~i~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB1_A 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_dssp CCHHHHHHGGGCSCHHHHHHHHHHHGGGGSSGG--GGGGGHHHHHHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHhHhcCCCC--chhhhcCCchHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH Confidence 456677777777777888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. + ++++.|+.++.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB1_A 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_dssp HHHCCCCCSTHHHHHHHHHHHC T ss_pred HHHHHhhcChHHHHHHHHHHHc Confidence 556666 5 888888888874 No 154 >6HB2_D Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; HET: MSE; 2.7A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.61 E-value=5.3e-06 Score=85.37 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...++.++..++.++.++..... ...+... +.++.|+.++.. ..++.++..++.+|.+++.... T Consensus 9 ~~i~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB2_D 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_dssp HHHHHHHGGGGCSCHHHHHHHHHHHGGGGSSGG--GGGGGHHHHHHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHhHhcCCCC--chhhhcCCchHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH Confidence 456677777777777888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. + ++++.|+.++.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB2_D 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_dssp HHHCCCCCCTHHHHHHHHHHSC T ss_pred HHHHHhhcChHHHHHHHHHHHc Confidence 556666 5 888888888874 No 155 >2W3C_A GENERAL VESICULAR TRANSPORT FACTOR P115; MEMBRANE VESICLE TETHERING, ARMADILLO FOLD; HET: PEG; 2.22A {HOMO SAPIENS} Probab=96.59 E-value=5.7e-06 Score=90.00 Aligned_cols=135 Identities=13% Similarity=0.124 Sum_probs=95.4 Template_Neff=10.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE-SAKQQVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~-~~~~~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++.+.+..++..++.+|..++...+ .....+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 71 ~i~~L~~ll~~~~~~v~~~a~~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~~~~~a~~~L~~l~~~~~~~~~ 150 (577) T 2W3C_A 71 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 150 (577) T ss_dssp HHHHHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhchHHHHHHHHhCCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 45566666766778889999999999987543 2222333 246788888888877788899999999999875444444 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEEL-IA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~L-ve-giLe~Lv~LL~~ 381 (747) .+...+.++.|+.++. ... ..++..++.+|.+++........+ .+ ++++.|+.+|.. T Consensus 151 ~~~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~i~~L~~lL~~ 213 (577) T 2W3C_A 151 IVAFENAFERLLDIIS-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 213 (577) T ss_dssp HHHHTTHHHHHHHHHH-HTTGGGSCHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGGSGGGCC T ss_pred HHHcCCHHHHHHHHHH-HhCCCCCcHHHHHHHHHHHHHHccCHHHHHHHHhcChHHHHHHHHhc Confidence 4444678888888886 322 257788899999998765433333 34 788889888875 No 156 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.58 E-value=5.2e-06 Score=81.38 Aligned_cols=114 Identities=19% Similarity=0.154 Sum_probs=76.5 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 172 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 251 (423) T 4XZR_B 172 ALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVV 251 (423) T ss_dssp GHHHHHHHTTCSCHHHHHHHHHHHHHHTSSSHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888888888876544333334444567777777777777888889999988876543332223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 252 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 285 (423) T 4XZR_B 252 INAGVLPALRLLLS-SPKENIKKEACWTISNITAG 285 (423) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcC Confidence 33356667777775 45667777888888877764 No 157 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=96.56 E-value=6e-06 Score=75.59 Aligned_cols=136 Identities=22% Similarity=0.238 Sum_probs=88.7 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++.+.+..++..++.+|.+++.........+...+.++.++.++. ..+..++..++.++.+++... ..... T Consensus 53 ~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~-~~~~~ 131 (233) T 3TT9_A 53 GILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSND-KLKNL 131 (233) T ss_dssp HHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSG-GGHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCCcHHHHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHHHHccCH-HHHHH Confidence 4556666676667788889999999988644444444555577788888887 556778888999999987643 22233 Q NP_000290.2 325 TRRQNGIREAVSLLRRT--------------GNAEIQKQLTGLLWNLSS-TDELKEELIA-DA-LPVLADRVIIP 382 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss--------------~d~eVr~~AL~aLsnLas-~~~~~~~Lve-gi-Le~Lv~LL~~~ 382 (747) +...+++..+..++... .+..++..++.++.+++. .......+.. +. ++.|+.++... T Consensus 132 ~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~ 206 (233) T 3TT9_A 132 MITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGT 206 (233) T ss_dssp HHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHHHHHHHTTSCHHHHHHHHTSTTHHHHHHHHHHHH T ss_pred hhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHHHHHHHHhcCHHHHHHHHHcccHHHHHHHHHHcc Confidence 33334455555554311 135677888899999887 4444444444 55 78888877653 No 158 >6HB3_B Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 3.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.56 E-value=6.6e-06 Score=84.61 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...+..++..++.++.++..... ...+... +.++.|+.++.. ..+..++..++.+|.+++.... T Consensus 9 ~~~~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB3_B 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_pred CcHHHHHHHccCCCHHHHHHHHHHHHHHcCChh--HHHHHHhCCCcHHHHHHHHhCCCCCCHHHHHHHHHHHHHHcCCHH Confidence 456677777776677888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. . ++++.|+.+|.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB3_B 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_pred HHHHHHhccCCcHHHHHHHhcC Confidence 556666 5 888888888874 No 159 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=96.54 E-value=6.4e-06 Score=88.93 Aligned_cols=322 Identities=20% Similarity=0.248 Sum_probs=204.5 Template_Neff=11.900 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELK 364 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~ 364 (747) ...++.+...+...+..++..++.+|..++.........+...++++.+...+. ..++.++..++.++..++... ... T Consensus 177 ~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~ 255 (671) T 6SA8_A 177 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQI 255 (671) T ss_dssp HHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHHHH T ss_pred HHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHH Confidence 355667777777777778888888888887654333333444567777888886 557788999999999988743 222 Q NP_000290.2 365 EELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQT 443 (747) Q Consensus 365 ~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 443 (747) ..+.. ++++.|+.++.. .++++-..+..+|..-. .. ....+.. T Consensus 256 ~~~~~~~~~~~l~~~l~~----------------~~~~v~~~a~~~L~~l~---------~~-----------~~~~~~~ 299 (671) T 6SA8_A 256 QAVIDAGALPALVQLLSS----------------PNEQILQEALWALSNIA---------SG-----------GNEQIQA 299 (671) T ss_dssp HHHHHTTCHHHHHHHTTC----------------SCHHHHHHHHHHHHHHT---------TS-----------CHHHHHH T ss_pred HHHHHcCHHHHHHHHhcC----------------CCHHHHHHHHHHHHHHH---------cC-----------CcHHHHH Confidence 33333 677777777753 13444444444443211 00 0001111 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 523 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 523 (747) . -..++++.|+..++. .+..-...+...|.++.... T Consensus 300 ~-~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~~------------------------------------- 335 (671) T 6SA8_A 300 V-IDAGALPALVQLLSS------PNEQILQEALWALSNIASGG------------------------------------- 335 (671) T ss_dssp H-HHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSC------------------------------------- T ss_pred H-HHhChHHHHHHHhcC------CcHHHHHHHHHHHHHHhcCC------------------------------------- Confidence 1 113455555544431 11112222333333332110 Q NP_000290.2 524 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARL 603 (747) Q Consensus 524 ~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~L 603 (747) ......+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+...++++.|+.+ T Consensus 336 -------------~~~~~~~~~~~~l~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~ 396 (671) T 6SA8_A 336 -------------NEQIQAVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNE-----QIQAVIDAGALPALVQL 396 (671) T ss_dssp -------------HHHHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHG T ss_pred -------------cHHHHHHHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcH-----HHHHHHHcCcHHHHHHH Confidence 001112345667888888887 46778888999999999874332 23333456788899999 Q NP_000290.2 604 LQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 604 L~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) +.+.++.++..++.+|.+++... .. ......++++.|+.++.+ .++.++..++.+|.+++...+.....+.+ T Consensus 397 l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~ 470 (671) T 6SA8_A 397 LSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVID 470 (671) T ss_dssp GGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHH T ss_pred hcCCCHHHHHHHHHHHHhhcCCCHHHHHHHHhcCcHHHHHHHcCC------CCHHHHHHHHHHHHHHHcCChHHHHHHHh Confidence 98888899999999999998762 22 233445678888888876 36788999999999999765544455556 Q NP_000290.2 682 SSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 682 ~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .++++.|+.++.+. ++.++..++.+|.+++.. T Consensus 471 ~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~ 502 (671) T 6SA8_A 471 AGALPALVQLLSSP-NEQIQDEAEKTLLNIANG 502 (671) T ss_dssp TTHHHHHHHHTTCS-CHHHHHHHHHHHHHHHTS T ss_pred cCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHcC Confidence 67788888888876 788899999999998854 No 160 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=96.51 E-value=6.8e-06 Score=80.51 Aligned_cols=114 Identities=22% Similarity=0.183 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 214 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 293 (423) T 1EE4_A 214 IPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAV 293 (423) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhcCCCcchhHHHHHHHHHHHhCChHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 44556666666677888889999988876543333333334667777777777777888899999988876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 294 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 327 (423) T 1EE4_A 294 IDANLIPPLVKLLE-VAEDKTKKEACWAISNASSG 327 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHGG T ss_pred HHCCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHcC Confidence 34456677777775 55667788888888887764 No 161 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=96.51 E-value=6.8e-06 Score=80.51 Aligned_cols=114 Identities=22% Similarity=0.183 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 214 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 293 (423) T 1EE4_B 214 IPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAV 293 (423) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred HHHHHHHHhcCCCcchhHHHHHHHHHHHhCChHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 44556666666677888889999988876543333333334667777777777777888899999988876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 294 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 327 (423) T 1EE4_B 294 IDANLIPPLVKLLE-VAEDKTKKEACWAISNASSG 327 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHGG T ss_pred HHCCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHcC Confidence 34456677777775 55667788888888887764 No 162 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=96.45 E-value=9.9e-06 Score=98.55 Aligned_cols=150 Identities=9% Similarity=0.041 Sum_probs=112.4 Template_Neff=9.500 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.|+.+|. +.++.++..|+.+|..++.... ...+.+.. ++.|+.+|.+.++.++..++.+|++|+.. T Consensus 618 ~~~l~~L~~~l~-d~~~~vR~~a~~al~~l~~~~~-------~~~~~~~~-lp~L~~lL~d~~~~vr~~al~aL~~L~~~ 688 (1454) T 5KC2_B 618 DIILSHLITYLN-DKDPALRVSLIQTISGISILLG-------TVTLEQYI-LPLLIQTITDSEELVVISVLQSLKSLFKT 688 (1454) T ss_pred hhhHHHHHHHcc-CCCHHHHHHHHHHHHHHHHhhH-------HHHHHHcC-HHHHHHHhcCCCHHHHHHHHHHHHHHhhC Confidence 346788889998 5888999999999999986431 22223333 89999999988889999999999999876 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . .....+.. +++.+..++.+ .++.++..++.+|..|+..... .... ..+++.|+.+|.+. +..+++.| T Consensus 689 ~~~~~~~~~~-~l~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~--~~~~-~~~~~~L~~~L~d~-~~~vr~~a 757 (1454) T 5KC2_B 689 GLIRKKYYID-ISKTTSPLLLH------PNNWIRQFTLMIIIEIINKLSK--AEVY-CILYPIIRPFFEFD-VEFNFKSM 757 (1454) T ss_pred CHHHHHHHHH-HHHHHHHHHCC------CCHHHHHHHHHHHHHHhcCCCC--HHHH-cChHHHHHHHhcCC-CHHHHHHH Confidence 3 22222222 66777777766 3788999999999999875321 1122 45788899999877 88999999 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..++..+ T Consensus 758 ~~~L~~~~~~~ 768 (1454) T 5KC2_B 758 ISCCKQPVSRS 768 (1454) T ss_pred HHHHHHHhhcc Confidence 99999988765 No 163 >4B18_A IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE; TRANSPORT PROTEIN - PEPTIDE COMPLEX; 2.52A {HOMO SAPIENS} Probab=96.44 E-value=8.9e-06 Score=80.74 Aligned_cols=366 Identities=18% Similarity=0.167 Sum_probs=217.7 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.. .++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++........ T Consensus 61 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~ 140 (447) T 4B18_A 61 GVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 140 (447) T ss_dssp THHHHHHHHTTCTTCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred cHHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCcHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHHccChhHHH Confidence 345556666655 5677888889999888765433333333456777888888777788889999999988765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...++++.+...+....++.++..++.++..++........... ++++.+..++.. .+++ T Consensus 141 ~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~ 204 (447) T 4B18_A 141 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV----------------SDTD 204 (447) T ss_dssp HHHHTTCHHHHHHGGGCTTCHHHHHHHHHHHHHHHCCSSSCCCHHHHGGGHHHHHHHTTS----------------CCHH T ss_pred HHHHCCcHHHHHHHhhcCCChhHHHHHHHHHHHHhcCCCCCCcccccccHHHHHHHHhhC----------------CCHH Confidence 3334456777777775333457888888999888765432222211 455556655532 1334 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +...+..++..-... -+ ...+.+. -.+++..|...+.. .+..-.+.+...|.+ T Consensus 205 ~~~~a~~~l~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~ 257 (447) T 4B18_A 205 VLADACWALSYLSDG------PN--------------DKIQAVI-DAGVCRRLVELLMH------NDYKVVSPALRAVGN 257 (447) T ss_dssp HHHHHHHHHHHHTSS------SH--------------HHHHHHH-HTTCHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcC------CH--------------HHHHHHH-HCCHHHHHHHHHcC------CCHHHHHHHHHHHHH Confidence 444444333221100 00 0000000 12333333333321 111112222222322 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +.... ......+.+.++++.|+.++. +.+ T Consensus 258 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 286 (447) T 4B18_A 258 IVTGD--------------------------------------------------DIQTQVILNCSALQSLLHLLS-SPK 286 (447) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSS T ss_pred HhcCC--------------------------------------------------hHHHHHHhhcchHHHHHHHhc-CCC Confidence 22110 000112234567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFP 638 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~ 638 (747) +.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++.. ... ..+...++++ T Consensus 287 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ 361 (447) T 4B18_A 287 ESIKKEACWTISNITAGNRA-----QIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 361 (447) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHH T ss_pred HHHHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHHhcCCHHHHHHHHHHHHHHhccCCHHHHHHHHHCCcHH Confidence 78888999999999875332 223334567888899998888888999999999999875 222 2334446778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-----------QYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-----------~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .+..++.+ .++.++..++.+|.+++...+.... .+.+.++++.+..++.+. ++.++..++.+ T Consensus 362 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~-~~~v~~~a~~~ 434 (447) T 4B18_A 362 PLCDLLTV------MDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHE-NQEIYQKAFDL 434 (447) T ss_dssp HHHHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHSSCCSCHHHHHHHHTTHHHHHHHGGGSS-CHHHHHHHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhHHHHhhCCCCCCHHHHHHHHhccHHHHHHHHhCC-CHHHHHHHHHH Confidence 88888776 3678889999999999875332221 233445677777777666 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) +.++....+ T Consensus 435 l~~l~~~~~ 443 (447) T 4B18_A 435 IEHYFGTED 443 (447) T ss_dssp HHHHCC--- T ss_pred HHHHhcCcc Confidence 988876543 No 164 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=96.44 E-value=9e-06 Score=82.47 Aligned_cols=363 Identities=19% Similarity=0.190 Sum_probs=216.7 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+... +..++..++.++..+..... ... T Consensus 143 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~-~~~ 221 (529) T 1JDH_A 143 GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS-NKP 221 (529) T ss_dssp THHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT-HHH T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCc-cHH Confidence 3455666667667788888999999988754444333444455777777777654 56778888888888875432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..++.++..++.++..++....... ...++++.+..++.. -++++. T Consensus 222 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~-~~~~~~~~l~~~l~~----------------~~~~~~ 283 (529) T 1JDH_A 222 AIVEAGGMQALGLHLT-DPSQRLVQNCLWTLRNLSDAATKQE-GMEGLLGTLVQLLGS----------------DDINVV 283 (529) T ss_dssp HHHHTTHHHHHHTTTT-SSCHHHHHHHHHHHHHHHTTCTTCS-CCHHHHHHHHHHTTC----------------SCHHHH T ss_pred HHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHcchhhhHH-HHchHHHHHHHHhCC----------------CCHHHH Confidence 3333456777777776 4566788888888888876432211 112455556655541 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-... .+. .+..+ .-.+.++.++..+.. ..-+..-.+.+...|.++. T Consensus 284 ~~a~~~l~~l~~~------~~~--------------~~~~~-~~~~~~~~l~~~l~~----~~~~~~~~~~a~~~l~~l~ 338 (529) T 1JDH_A 284 TCAAGILSNLTCN------NYK--------------NKMMV-CQVGGIEALVRTVLR----AGDREDITEPAICALRHLT 338 (529) T ss_dssp HHHHHHHHHHTTT------CHH--------------HHHHH-HHTTHHHHHHHHHHH----HTTCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhcC------CHH--------------HHHHH-HHcCHHHHHHHHHHh----cCCChHhHHHHHHHHHHHh Confidence 3333333221100 000 00000 012233333332211 0111222333444444443 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ....... .....+...++++.++.++....++. T Consensus 339 ~~~~~~~-----------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~ 371 (529) T 1JDH_A 339 SRHQEAE-----------------------------------------------MAQNAVRLHYGLPVVVKLLHPPSHWP 371 (529) T ss_dssp SSSTTHH-----------------------------------------------HHHHHHHHTTCHHHHHHTTSTTCCHH T ss_pred cCcccHH-----------------------------------------------HHHHHHHhcccHHHHHHHHCCCCCHH Confidence 2211000 00111234566778888887323667 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN----------------------SDVVRSGASLLSN 621 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d----------------------~eVr~~AL~aLsn 621 (747) ++..++.+|.+++.... ....+...++++.|..++.+.+ +.++..++.+|.+ T Consensus 372 ~~~~a~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~ 445 (529) T 1JDH_A 372 LIKATVGLIRNLALCPA------NHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHI 445 (529) T ss_dssp HHHHHHHHHHHHTTSGG------GHHHHHHTTHHHHHHHHHHHHHHHHC-----------CBTTBCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcChh------hhHHHHhcCHHHHHHHHHHhcChhHHHHHhccCcchhHhccCCHHHHHHHHHHHHHH Confidence 88889999999887532 1333345678888888887654 6788889999999 Q NP_000290.2 622 MSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 622 La~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ++..... ..+...++++.+..++.+ .++.++..++.+|.+++.. +.....+...++++.|..++.+. ++.+ T Consensus 446 l~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v 517 (529) T 1JDH_A 446 LARDVHNRIVIRGLNTIPLFVQLLYS------PIENIQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSR-NEGV 517 (529) T ss_dssp HTTSHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHGGGCS-SHHH T ss_pred HhcCccchHHHHhcCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-HHHHHHHHHcCcHHHHHHHHhcC-CHHH Confidence 9876433 233445677888888876 3678899999999999875 44455555667888899988876 7889 Q NP_000290.2 701 AEAARLLLSDMW 712 (747) Q Consensus 701 r~aAL~aLsnL~ 712 (747) +..++.+|.+++ T Consensus 518 ~~~a~~~L~~l~ 529 (529) T 1JDH_A 518 ATYAAAVLFRMS 529 (529) T ss_dssp HHHHHHHHHHHC T ss_pred HHHHHHHHHhcC Confidence 999999888763 No 165 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=96.43 E-value=9.2e-06 Score=73.31 Aligned_cols=135 Identities=19% Similarity=0.216 Sum_probs=90.0 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.++....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 88 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 167 (243) T 5MFI_B 88 GALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQK 167 (243) T ss_dssp TCHHHHHHHTSSSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred CcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34555666666667778888999999887644443334444567777888887777788888999998888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 168 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (243) T 5MFI_B 168 LIEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLEEAGAEPALEKLQS 224 (243) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGG T ss_pred HHHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhc Confidence 334456777777776 5567888889999999886332 2222333 56666666654 No 166 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=96.43 E-value=9.2e-06 Score=73.31 Aligned_cols=135 Identities=19% Similarity=0.216 Sum_probs=90.0 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.++....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 88 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 167 (243) T 5MFJ_B 88 GALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQK 167 (243) T ss_dssp TCHHHHHHHHHHSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred CcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34555666666667778888999999887644443334444567777888887777788888999998888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 168 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (243) T 5MFJ_B 168 LIEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLEEAGAEPALEKLQS 224 (243) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHTSS T ss_pred HHHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhc Confidence 334456777777776 5567888889999999886332 2222333 56666666654 No 167 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=96.43 E-value=1.1e-05 Score=87.33 Aligned_cols=182 Identities=12% Similarity=0.061 Sum_probs=127.6 Template_Neff=8.700 Q NP_000290.2 539 GSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLM----SSGMSQLIGLKEKGLPQIARLLQS------GN 608 (747) Q Consensus 539 ~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~----s~~~~~~llie~giI~~Ll~LL~s------~d 608 (747) ....+++.|+++.|+.+|. +++..+...++.+|.+++...... ........+.+.++++.|+.+|.. .+ T Consensus 60 ~~~~lv~~g~i~~Lv~LL~-~~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l~~~g~l~~Lv~~L~~~~e~~~~d 138 (490) T 4MFU_A 60 LYHLLVELNAVQSLLGLLG-HDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEE 138 (490) T ss_dssp CTHHHHHTTHHHHHHHHTS-CSSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHHHHTTHHHHHHHHHHHCCTTCHHH T ss_pred HHHHHHHCChHHHHHHHhC-CCCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHHHhCCHHHHHHHHHHhccccccch Confidence 3455678899999999998 466778888999999998643200 000013344577889999998875 55 Q NP_000290.2 609 SDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLN 686 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~ 686 (747) ...+..++.+|.+|+.. +.. ..+...++++.|+.++.... ....++..++.+|.+|+..++..+..+.+.++++ T Consensus 139 ~~~~~~al~~L~nL~~~~~~~~~~i~~~~~l~~Ll~~L~~~~----~~~~~k~~a~~~L~~L~~~~~~~~~~l~~~g~i~ 214 (490) T 4MFU_A 139 ADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM----PFDANKLYCSEVLAILLQDNDENRELLGELDGID 214 (490) T ss_dssp HHHHHHHHHHHHHHHHHSTTHHHHHCCCCCHHHHHHHHHCCS----CCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHH T ss_pred HHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCC----CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHH Confidence 67888999999999976 333 33445678888988887620 1367788999999999986566667777778899 Q NP_000290.2 687 NIINLCRS-----SA---SPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 687 ~Ll~LL~s-----~~---d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) .|+.++.. +. .......++.+|.+++...+.+..+.+.| T Consensus 215 ~Ll~lL~~~~~~d~~~~~~~e~~en~~~aL~~L~~~~~~~~~f~~~~ 261 (490) T 4MFU_A 215 VLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGE 261 (490) T ss_dssp HHHHHHHTTSSSCCSSHHHHHHHHHHHHHHHHHHHSTHHHHHHHHTT T ss_pred HHHHHHHhhhhcCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCC Confidence 99998851 11 12344556889999887776655554443 No 168 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=96.41 E-value=1e-05 Score=74.57 Aligned_cols=134 Identities=26% Similarity=0.306 Sum_probs=85.5 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 89 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (286) T 5AEI_B 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 168 (286) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCChHHHHHH Confidence 44556666666677788888999888876533333333344567777777777777888889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 169 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (286) T 5AEI_B 169 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 224 (286) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHcc Confidence 33456677777775 4566778888888888876422 2222222 45565655554 No 169 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=96.39 E-value=1.1e-05 Score=74.12 Aligned_cols=111 Identities=25% Similarity=0.289 Sum_probs=73.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 170 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 249 (281) T 4PLS_B 170 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 249 (281) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCcHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHHcCChhHHHHH Confidence 45556666666677888889999988876544333333444577777787877777888899999998885544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ...++++.+...+. ..++.++..++.++..+ T Consensus 250 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l 280 (281) T 4PLS_B 250 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKI 280 (281) T ss_dssp HTTTHHHHHHTTTS-CSCHHHHHHHHHHHHHC T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHhh Confidence 33356666666665 45666777777666554 No 170 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=96.38 E-value=1.4e-05 Score=88.57 Aligned_cols=181 Identities=12% Similarity=0.075 Sum_probs=128.1 Template_Neff=8.100 Q NP_000290.2 539 GSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSS---G--MSQLIGLKEKGLPQIARLLQS------G 607 (747) Q Consensus 539 ~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~---~--~~~~llie~giI~~Ll~LL~s------~ 607 (747) ....+++.|+++.|+.+|. +.+..++..++.+|.+|+..... .. . .....+.+.++++.|+.+|.. . T Consensus 138 ~~~~lv~~g~i~~Lv~LL~-~~n~di~~~a~~~L~~Lt~~~~~-~~~~~~~~~l~~~l~e~g~l~~Lv~~L~~l~e~~~~ 215 (568) T 4HM9_A 138 LYHLLVELNAVQSLLGLLG-HDNTDVSIAVVDLLQELTDIDTL-HESEEGAEVLIDALVDGQVVALLVQNLERLDESVKE 215 (568) T ss_dssp GHHHHHHTTHHHHHHHGGG-CSSHHHHHHHHHHHHHHTCHHHH-TTCHHHHHHHHHHHHHTTHHHHHHHHHTTCCTTSHH T ss_pred HHHHHHHCChHHHHHHHhC-CCCHHHHHHHHHHHHHHhCCccc-cCChhhHHHHHHHHHhCCHHHHHHHHHhcccccccc Confidence 4455678899999999998 46678888999999999864320 00 0 013344567889999998876 5 Q NP_000290.2 608 NSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSML 685 (747) Q Consensus 608 d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL 685 (747) +...+..++.+|.+|+.. +.. ..+...++++.|+.++.... .....+..|+.+|.+|+..++..+..+.+.+++ T Consensus 216 d~~~~~~al~iL~nL~~~~~~~~~~i~~~g~l~~Ll~lL~~~~----~~~~~k~~AaeiL~~L~~~~~~~r~~l~~~g~I 291 (568) T 4HM9_A 216 EADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM----PFDANKLYCSEVLAILLQDNDENRELLGELDGI 291 (568) T ss_dssp HHHHHHHHHHHHHHHHHHCGGGHHHHCCCCCHHHHHHHHHSSC----CCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHH T ss_pred hHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCC----CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchH Confidence 567888999999999975 333 23445678888998887520 145678889999999998656677777778889 Q NP_000290.2 686 NNIINLCRS-----SA---SPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 686 ~~Ll~LL~s-----~~---d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) +.|+.++.. .. .....+.++.+|..++...+.+..+...| T Consensus 292 ~~LL~lL~~y~~~d~~~~~e~e~~en~~~aL~~L~~~~~~r~~f~~~~ 339 (568) T 4HM9_A 292 DVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGE 339 (568) T ss_dssp HHHHHHHGGGTTSCCSSSHHHHHHHHHHHHHHHHTTSTHHHHHHHHTT T ss_pred HHHHHHHHhhhccCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCC Confidence 999998851 11 12345566889999888776655444443 No 171 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=96.36 E-value=1.3e-05 Score=86.31 Aligned_cols=135 Identities=19% Similarity=0.251 Sum_probs=86.7 Template_Neff=11.000 Q NP_000290.2 246 TIPKAVQYLSS------QDEKYQAIGAYYIQHTCFQDE-------------------------SAKQQVYQLGGICKLVD 294 (747) Q Consensus 246 iL~~Ll~lL~s------sd~eVr~sAL~aLsnLs~~~~-------------------------~~~~~li~~~IL~~Ll~ 294 (747) +++.++.++.. .+..++..++.+|.+++.... .....+...++++.+.. T Consensus 236 ~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ 315 (584) T 3L6X_A 236 LVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGTSPARGYELLFQPEVVRIYIS 315 (584) T ss_dssp HHHHHHHHHHHHHHTTCCSCHHHHHHHHHHHHHHTTHHHHSTTCCC--------------CCCCGGGGGGSHHHHHHHHH T ss_pred HHHHHHHHHHHHhcCCCCChHHHHHHHHHHHHHHhhhhccChhHHHHHHhcCcCCCCCCCCChhhhhHhhChhHHHHHHH Confidence 34555565553 356677888888888875421 11223334567777777 Q NP_000290.2 295 LLRSP-NQNVQQAAAGALRNLVFRS----TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA 369 (747) Q Consensus 295 lL~s~-d~eVr~~AL~aLs~La~~~----~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve 369 (747) ++... ++.++..++.+|.+++... ......+...++++.+..++. ..+..++..++.+|.+++........+.. T Consensus 316 ll~~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~l~~L~~ll~-~~~~~v~~~a~~~L~~L~~~~~~~~~l~~ 394 (584) T 3L6X_A 316 LLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLT-NEHERVVKAASGALRNLAVDARNKELIGK 394 (584) T ss_dssp HHHHCCCHHHHHHHHHHHHHHHSSCSHHHHHHHHHHTSHHHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTTCSCHHHHHH T ss_pred HHHcCCCHHHHHHHHHHHHHHhCCCccCCHHHHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcChHHHHHHHc Confidence 77765 7788889999999987642 222233334467778888886 56678888999999999876444333333 Q NP_000290.2 370 DALPVLADRVII 381 (747) Q Consensus 370 giLe~Lv~LL~~ 381 (747) ++++.|+.+|.. T Consensus 395 ~~l~~L~~~L~~ 406 (584) T 3L6X_A 395 HAIPNLVKNLPG 406 (584) T ss_dssp HHHHHHHHTSSS T ss_pred chHHHHHHcCCC Confidence 566666666643 No 172 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=96.35 E-value=1.2e-05 Score=78.71 Aligned_cols=134 Identities=17% Similarity=0.197 Sum_probs=87.3 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+..++.+.++.++..++.++..++...+.....+ T Consensus 223 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 302 (426) T 4U5L_A 223 VVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQV 302 (426) T ss_dssp CHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCccHHHHHHHHHHHHhcCCHHHHHHHhccchHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666777888889999998886544333344445677778888877778888899999998886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD--ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~--~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++... .....+.. ++++.|..++. T Consensus 303 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 359 (426) T 4U5L_A 303 VNHGLVPFLVGVLS-KADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLS 359 (426) T ss_dssp HHTTCHHHHHHHHH-SSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhc Confidence 33456777777776 456677888888888887631 11122222 45555555544 No 173 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=96.34 E-value=1.3e-05 Score=79.63 Aligned_cols=366 Identities=18% Similarity=0.167 Sum_probs=218.3 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.. .++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++........ T Consensus 64 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~ 143 (450) T 2JDQ_A 64 GVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 143 (450) T ss_dssp THHHHHHHHHTCTTCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred chHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCcHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHH Confidence 345556666655 5677888888888888765443333333456777888888777788899999999988765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...++++.+...+....++.++..++.++..++........... ++++.+..++.. .+++ T Consensus 144 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~ 207 (450) T 2JDQ_A 144 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV----------------SDTD 207 (450) T ss_dssp HHHHTTCHHHHHHHTTSCCCHHHHHHHHHHHHHHHCCSSSCCCGGGTGGGHHHHHHHTTC----------------CCHH T ss_pred HHHHCCCHHHHHHHHhhccchhHHHHHHHHHHHHhcCCCCCchhhhhhhHHHHHHHHhcC----------------CCHH Confidence 3334566777777776333457888888999888765432222221 455556655543 1334 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +...+..+|..-... .+ ...+.. -..+++..|...+++ -+..-.+.++..|.+ T Consensus 208 ~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~ 260 (450) T 2JDQ_A 208 VLADACWALSYLSDG------PN--------------DKIQAV-IDAGVCRRLVELLMH------NDYKVVSPALRAVGN 260 (450) T ss_dssp HHHHHHHHHHHHTSS------SH--------------HHHHHH-HHTTTHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcC------CH--------------HHHHHH-HHCCHHHHHHHHHcC------CCHHHHHHHHHHHHH Confidence 444444333221000 00 000000 012344444433321 011111222222222 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +...- ......+.+.++++.++.++. +.+ T Consensus 261 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 289 (450) T 2JDQ_A 261 IVTGD--------------------------------------------------DIQTQVILNCSALQSLLHLLS-SPK 289 (450) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHTT-CSS T ss_pred HhhCC--------------------------------------------------hHHHHHHhhcchHHHHHHHhc-CCC Confidence 22100 000112234567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFP 638 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~ 638 (747) +.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...++++ T Consensus 290 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ 364 (450) T 2JDQ_A 290 ESIKKEACWTISNITAGNRA-----QIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 364 (450) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHH T ss_pred HHHHHHHHHHHHHHhcCCHH-----HHHHHHhCCHHHHHHHHHhcCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHH Confidence 78888999999999875332 223334567888899998888888999999999999876 222 2334456788 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-----------QYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-----------~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .+..++.+ .++.++..++.+|.+++...+.... .+.+.+.++.+..++.+. ++.++..++.+ T Consensus 365 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~l~~~~-~~~v~~~a~~~ 437 (450) T 2JDQ_A 365 PLCDLLTV------MDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHE-NQEIYQKAFDL 437 (450) T ss_dssp HHHHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHSCSCCCHHHHHHHHHHCHHHHHHHHCHH-HHHHHHHHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhHHHHhhCCCCCCHHHHHHHHhccHHHHHHHHhCC-CHHHHHHHHHH Confidence 88888876 3678888999999999875332221 233445667776666665 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) +.++....+ T Consensus 438 l~~~~~~~~ 446 (450) T 2JDQ_A 438 IEHYFGTED 446 (450) T ss_dssp HHHHHCCC- T ss_pred HHHHhcCcc Confidence 988876544 No 174 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=96.33 E-value=1.5e-05 Score=88.20 Aligned_cols=169 Identities=12% Similarity=0.125 Sum_probs=105.6 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKK----DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-----DV-- 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d----~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-----eV-- 611 (747) +++.|+++.|+.++.. .. ..++..++.+|.+++..+.. ....+.+.++++.|..++...+. .. T Consensus 204 l~~~g~~~~L~~ll~~-~~~~~~~~v~~~al~~L~~L~~~~~~-----~~~~~~e~~~i~~L~~lL~~~~~~~~~~~~~~ 277 (651) T 3GQ2_A 204 VAFENAFERLLDIITE-EGNSDGGIVVEDCLILLQNLLKNNNS-----NQNFFKEGSYIQRMKPWFEVGDENSGWSAQKV 277 (651) T ss_dssp HHHTTHHHHHHHHHHH-TTGGGSHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTCGGGTGGGGCCCSSCCCCCHHHH T ss_pred HHhCChHHHHHHHHHH-hCCCCccHHHHHHHHHHHHHHhCCHH-----HHHHHHhcChHHHHHHHHhcCCccCCCchHHH Confidence 4577889999998873 32 25777899999999875432 34455567889999988874331 11 Q NP_000290.2 612 --VRSGASLLSNMSRH-------PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 612 --r~~AL~aLsnLa~~-------~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) ...++.++..++.. ... ..+...++++.|+.++.... .+..++..++.+|++++..++.....+.+ T Consensus 278 ~~~~~~~~il~~l~~~~~~~~~~~~~~~~l~~~g~l~~L~~ll~~~~----~~~~v~~~a~~~La~l~~~~~~~q~~~~~ 353 (651) T 3GQ2_A 278 TNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATG----VPADILTETINTVSEVIRGCQVNQDYFAS 353 (651) T ss_dssp HHHHHHHHHHHHHHCTTSCHHHHHHHHHHHHHTTHHHHHHHHHHCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHH T ss_pred HHHHHHHHHHHHHhCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHhcC----CCHHHHHHHHHHHHHHHhcCHHHHHHHHh Confidence 22334444444421 112 23356678888888886520 14578889999999998865555444444 Q NP_000290.2 682 S--------SMLNNIINLCRSS-ASPKAAEAARLLLSDMWSS-KELQGVL 721 (747) Q Consensus 682 ~--------giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~-~~~~~~~ 721 (747) . +.+..|+.++... .+..++..++.+|.+++.. .+.+..+ T Consensus 354 ~~~~~~~~~~~l~~Ll~~l~~~~~~~~~r~~al~~L~~~~~~~~~~~~~l 403 (651) T 3GQ2_A 354 VNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEI 403 (651) T ss_dssp CBCCSSSCCBHHHHHHHHHTCTTSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred CCCCCCCCchHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 2 2355666665432 1567888999999666653 3334333 No 175 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=96.33 E-value=1.5e-05 Score=88.20 Aligned_cols=169 Identities=12% Similarity=0.125 Sum_probs=105.6 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKK----DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-----DV-- 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d----~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-----eV-- 611 (747) +++.|+++.|+.++.. .. ..++..++.+|.+++..+.. ....+.+.++++.|..++...+. .. T Consensus 204 l~~~g~~~~L~~ll~~-~~~~~~~~v~~~al~~L~~L~~~~~~-----~~~~~~e~~~i~~L~~lL~~~~~~~~~~~~~~ 277 (651) T 3GRL_A 204 VAFENAFERLLDIITE-EGNSDGGIVVEDCLILLQNLLKNNNS-----NQNFFKEGSYIQRMKPWFEVGDENSGWSAQKV 277 (651) T ss_dssp HHHTTHHHHHHHHHHH-HTGGGSHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTCGGGGGGGGCCCSCSSCCCHHHH T ss_pred HHhCChHHHHHHHHHH-hCCCCccHHHHHHHHHHHHHHhCCHH-----HHHHHHhcChHHHHHHHHhcCCccCCCchHHH Confidence 4577889999998873 32 25777899999999875432 34455567889999988874331 11 Q NP_000290.2 612 --VRSGASLLSNMSRH-------PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 612 --r~~AL~aLsnLa~~-------~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) ...++.++..++.. ... ..+...++++.|+.++.... .+..++..++.+|++++..++.....+.+ T Consensus 278 ~~~~~~~~il~~l~~~~~~~~~~~~~~~~l~~~g~l~~L~~ll~~~~----~~~~v~~~a~~~La~l~~~~~~~q~~~~~ 353 (651) T 3GRL_A 278 TNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATG----VPADILTETINTVSEVIRGCQVNQDYFAS 353 (651) T ss_dssp HHHHHHHHHHHHHTCTTSCHHHHHHHHHHHHHTTHHHHHHHHHTCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHH T ss_pred HHHHHHHHHHHHHhCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHhcC----CCHHHHHHHHHHHHHHHhcCHHHHHHHHh Confidence 22334444444421 112 23356678888888886520 14578889999999998865555444444 Q NP_000290.2 682 S--------SMLNNIINLCRSS-ASPKAAEAARLLLSDMWSS-KELQGVL 721 (747) Q Consensus 682 ~--------giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~-~~~~~~~ 721 (747) . +.+..|+.++... .+..++..++.+|.+++.. .+.+..+ T Consensus 354 ~~~~~~~~~~~l~~Ll~~l~~~~~~~~~r~~al~~L~~~~~~~~~~~~~l 403 (651) T 3GRL_A 354 VNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEI 403 (651) T ss_dssp CEESSSSCEEHHHHHHHHHTCTTSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred CCCCCCCCchHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 2 2355666665432 1567888999999666653 3334333 No 176 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=96.31 E-value=1.5e-05 Score=72.85 Aligned_cols=113 Identities=18% Similarity=0.215 Sum_probs=69.5 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP---------------NQNVQQAAAG 309 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~---------------d~eVr~~AL~ 309 (747) +++.++.++. ..+..++..++.++.+++... .....+...+++..+..++... +..++..++. T Consensus 95 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~ 173 (233) T 3TT9_A 95 GVPRLLQVLKQTRDLETKKQITGLLWNLSSND-KLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTG 173 (233) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSG-GGHHHHHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHH T ss_pred cHHHHHHHHhhCCCHHHHHHHHHHHHHHccCH-HHHHHhhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHH Confidence 4555666665 456778888999999987633 2233333344555555554322 4567778888 Q NP_000290.2 310 ALRNLVFRSTTNKLETRRQNG-IREAVSLLRRTG------NAEIQKQLTGLLWNLSST 360 (747) Q Consensus 310 aLs~La~~~~~~~~~ll~~~I-L~~Ll~lL~ss~------d~eVr~~AL~aLsnLas~ 360 (747) ++.+++...+.....+...+. ++.+..++. .. ++.++..++.+|.+++.. T Consensus 174 ~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~~L~~l~~~ 230 (233) T 3TT9_A 174 CLRNMSSAGADGRKAMRRCDGLIDSLVHYVR-GTIADYQPDDKATENCVCILHNLSYQ 230 (233) T ss_dssp HHHHHTTSCHHHHHHHHTSTTHHHHHHHHHH-HHHHTTCTTCHHHHHHHHHHHHHCCC T ss_pred HHHHHHhcCHHHHHHHHHcccHHHHHHHHHH-cccccCCCChHHHHHHHHHHHHhhhc Confidence 888887643333333433344 777777775 33 466777788888777653 No 177 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=96.29 E-value=1.5e-05 Score=79.23 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=78.1 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 273 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 352 (466) T 5D5K_C 273 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 352 (466) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hhHhHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4555666666667788888999998887654433333444467777888887777788889999998887642 222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 353 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 386 (466) T 5D5K_C 353 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 386 (466) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 178 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=96.28 E-value=1.6e-05 Score=79.14 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=78.0 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 273 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 352 (466) T 4UAF_B 273 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 352 (466) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4555666666667788888999999887654433333444467777888887777788889999998887642 222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 353 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 386 (466) T 4UAF_B 353 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 386 (466) T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 179 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=96.23 E-value=1.8e-05 Score=78.41 Aligned_cols=134 Identities=18% Similarity=0.203 Sum_probs=87.8 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.......... T Consensus 235 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 314 (450) T 2JDQ_A 235 VCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTV 314 (450) T ss_dssp THHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHHcCCCHHHHHHHHHHHHHHhhCChHHHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666677888889999998887544333333334677778888877777888899999998876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.. ......+.. ++++.|..++. T Consensus 315 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 371 (450) T 2JDQ_A 315 IDANIFPALISILQ-TAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLT 371 (450) T ss_dssp HHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGG T ss_pred HhCCHHHHHHHHHh-cCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhh Confidence 34457777777776 55677888888888888764 222222222 45555555554 No 180 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=96.23 E-value=1.8e-05 Score=80.55 Aligned_cols=367 Identities=18% Similarity=0.234 Sum_probs=218.1 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+... +..++..++.++..+..... ... T Consensus 145 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~-~~~ 223 (553) T 3IFQ_A 145 DGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPS-NKP 223 (553) T ss_dssp TGGGGTGGGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT-HHH T ss_pred CHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHHhcCCcHHHHHHHHHHHHHHhCCcc-hHH Confidence 4556666667667778888899999988764443333333445677777777654 56778888888888876322 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..++.++..++.++..++....... ...++++.+..++.. .++++. T Consensus 224 ~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~-~~~~~~~~l~~~l~~----------------~~~~~~ 285 (553) T 3IFQ_A 224 AIVEAGGMQALGKHLT-SNSPRLVQNCLWTLRNLSDVATKQE-GLESVLKILVNQLSV----------------DDVNVL 285 (553) T ss_dssp HHHHTTHHHHHHGGGG-SSCHHHHHHHHHHHHHHHTTCTTCS-CCHHHHHHHHTTTTC----------------CCHHHH T ss_pred HHHHCchHHHHHHHHh-cCCHHHHHHHHHHHHHhCChhHHHH-HHHHHHHHHHHHcCC----------------CCHHHH Confidence 3333456777777776 5567788888888888876432211 112455555555532 133333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ..+ ...+.+. -.+.++.++..+.. ..-+..-.+.+..+|.++. T Consensus 286 ~~a~~~l~~l~~------~~~--------------~~~~~~~-~~~~~~~l~~~l~~----~~~~~~~~~~a~~~l~~l~ 340 (553) T 3IFQ_A 286 TCATGTLSNLTC------NNS--------------KNKTLVT-QNSGVEALIHAILR----AGDKDDITEPAVCALRHLT 340 (553) T ss_dssp HHHHHHHHHHTT------TCH--------------HHHHHHT-TTTHHHHHHHHHHH----HTTCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc------CCH--------------HHHHHHH-HccHHHHHHHHHHH----cCCChHhHHHHHHHHHHHh Confidence 333333321100 000 0000000 01233333332211 0011222333344444443 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+.. ......+...++++.++.++....++. T Consensus 341 ~~~~~~-----------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 373 (553) T 3IFQ_A 341 SRHPEA-----------------------------------------------EMAQNSVRLNYGIPAIVKLLNQPNQWP 373 (553) T ss_dssp SSSTTH-----------------------------------------------HHHHHHHHTTTHHHHHHHGGGCTTCHH T ss_pred cCCChH-----------------------------------------------HHHHHHHHHcchHHHHHHHHcCCCChH Confidence 211100 000112234566788888887322367 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS---------------------DVVRSGASLLSNM 622 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~---------------------eVr~~AL~aLsnL 622 (747) ++..++.+|.+++.... ....+...++++.|..++.+.+. .++..++.+|.++ T Consensus 374 ~~~~a~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l 447 (553) T 3IFQ_A 374 LVKATIGLIRNLALCPA------NHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHIL 447 (553) T ss_dssp HHHHHHHHHHHHTTSGG------GHHHHHHTTHHHHHHHHHHHHHHHHHHHHHTTCCCTTCSSCCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcCcc------cHHHHHHccHHHHHHHHHHHcCcchhHHHhhcccCccccCCCHHHHHHHHHHHHHHH Confidence 78889999999887532 12333456788888888876554 7888899999998 Q NP_000290.2 623 SRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 623 a~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) +..... ......++++.+..++.+ .++.++..++.+|.+++.. +.....+.+.++++.|..++.+. ++.++ T Consensus 448 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 519 (553) T 3IFQ_A 448 ARDPMNRMEIFRLNTIPLFVQLLYS------SVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR-NEGTA 519 (553) T ss_dssp TTSHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTTHHHHHHHTTCS-SHHHH T ss_pred hcChhhHHHHHHcCChHHHHHHHhC------CCHHHHHHHHHHHHHHHcC-HHHHHHHHHCCcHHHHHHHHhCC-CHHHH Confidence 875333 233445677888888775 3678899999999999875 44555555667888898888877 78899 Q NP_000290.2 702 EAARLLLSDMWSSKE 716 (747) Q Consensus 702 ~aAL~aLsnL~~~~~ 716 (747) ..++.+|.+++...+ T Consensus 520 ~~a~~~l~~l~~~~~ 534 (553) T 3IFQ_A 520 TYAAAVLFRISEDKN 534 (553) T ss_dssp HHHHHHHHHTTSTTC T ss_pred HHHHHHHHHHHcccC Confidence 999999999996543 No 181 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=96.23 E-value=1.9e-05 Score=78.53 Aligned_cols=116 Identities=19% Similarity=0.202 Sum_probs=77.5 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++..+....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 172 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 251 (456) T 4BQK_A 172 PALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQC 251 (456) T ss_dssp THHHHHHHHTTCCCHHHHHHHHHHHHHHTSSSHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34556666666677788888999998887654433333334466777777777777788888999998887654333233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+....++.++..++.++..++.. T Consensus 252 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~ 287 (456) T 4BQK_A 252 IIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAG 287 (456) T ss_dssp HHTTTHHHHHHHHHHSCCCHHHHHHHHHHHHHHHTS T ss_pred HHHCChHHHHHHHHHcCCCHHHHHHHHHHHHHHhcC Confidence 333456677777775222566777888888887754 No 182 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=96.17 E-value=2.2e-05 Score=76.74 Aligned_cols=115 Identities=21% Similarity=0.205 Sum_probs=78.3 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..++...+..... T Consensus 180 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 259 (426) T 4U5L_A 180 QILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQK 259 (426) T ss_dssp HHHHHHHHHTTSSCHHHHHHHHHHHHHHTSSCHHHHHHHHTTTCHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHHhCCCHHHHHHHHHHHHHHhhCCcHHHHHHhhcChHHHHHHHhcCCCccHHHHHHHHHHHHhcCCHHHHHH Confidence 45556666666677788888999998887654433333344457777888887777788889999998888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+. +.++.++..++.++..++.. T Consensus 260 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 294 (426) T 4U5L_A 260 VIDAGALAVFPSLLT-NPKTNIQKEATWTMSNITAG 294 (426) T ss_dssp HHHTTGGGGHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HhccchHHHHHHHhc-CCChHHHHHHHHHHHHHhcC Confidence 334456677777775 45667777777777777653 No 183 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=96.16 E-value=2.3e-05 Score=77.77 Aligned_cols=135 Identities=18% Similarity=0.197 Sum_probs=84.9 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++..+....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 170 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 249 (454) T 4BPL_A 170 PALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQC 249 (454) T ss_dssp THHHHHHHHTTCCCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhhCCChHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666677788888999998887654433333334456777777777777788888999998887654333233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRV 379 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL 379 (747) +...++++.+...+....++.++..++.++..++..... ...+.. ++++.|..++ T Consensus 250 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l 306 (454) T 4BPL_A 250 IIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLL 306 (454) T ss_dssp HHTTTHHHHHHHHHHSSCCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHH T ss_pred HHHCChHHHHHHHHHhcCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCcHHHHHHHh Confidence 333456677777775222567778888888887754321 112222 4555555544 No 184 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=96.12 E-value=2.6e-05 Score=79.03 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=77.9 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 317 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 396 (509) T 4MZ6_E 317 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 396 (509) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4455566666667788888999998887654433333444467777888887777788889999998887642 222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 397 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 430 (509) T 4MZ6_E 397 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCCHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 185 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=96.12 E-value=2.6e-05 Score=79.03 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=77.9 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 317 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 396 (509) T 5UMZ_B 317 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 396 (509) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4455566666667788888999998887654433333444467777888887777788889999998887642 222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 397 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 430 (509) T 5UMZ_B 397 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCCHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 186 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=96.12 E-value=2.7e-05 Score=78.66 Aligned_cols=113 Identities=17% Similarity=0.130 Sum_probs=78.1 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRST-TNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~-~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++.... ..... T Consensus 292 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 371 (485) T 4E4V_A 292 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVY 371 (485) T ss_dssp GGGGHHHHHTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCHHHHHH Confidence 45556666666677888889999998876544333334444677778888877777888889999988876422 22222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 372 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 405 (485) T 4E4V_A 372 LVHCGIIEPLMNLLT-AKDTKIILVILDAISNIFQ 405 (485) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988886 No 187 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=96.07 E-value=3.4e-05 Score=85.21 Aligned_cols=176 Identities=12% Similarity=0.192 Sum_probs=126.8 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSG--------------MSQLIGL-KEKGLPQIARLLQS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~--------------~~~~lli-e~giI~~Ll~LL~s 606 (747) ++..++++.|+.+|... .+..++..++.+|.+++...+. .. .....+. +.+.++.|+.++.+ T Consensus 56 ~v~~~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~ 133 (651) T 3GQ2_A 56 EVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEE--EEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEE 133 (651) T ss_dssp HHHHHHHHHHHHHHTTCTTCHHHHHHHHHHHHHHHCCSSS--CC----------CHHHHHHHHHHTSHHHHHTHHHHTTC T ss_pred HHHccHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCCh--HhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccC Confidence 46778999999999731 3567788899999998864321 00 0012223 57888999999888 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHP--LLH-RVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS 682 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~--e~~-~ll-~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~ 682 (747) .++.++..++++|.+++... ... .++ ..++++.|+.+|.+ .+..++..++.+|.+++..+++....+... T Consensus 134 ~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~------~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~ 207 (651) T 3GQ2_A 134 FDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLAD------SREVIRNDGVLLLQALTRSNGAIQKIVAFE 207 (651) T ss_dssp CCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGGC------SSHHHHHHHHHHHHHHHTTCHHHHHHHHHT T ss_pred CCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHhC Confidence 88889999999999998773 222 233 45678889998876 367888999999999998555666666677 Q NP_000290.2 683 SMLNNIINLCRSSAS---PKAAEAARLLLSDMWSSK-ELQGVLRQQGF 726 (747) Q Consensus 683 giL~~Ll~LL~s~~d---~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~ 726 (747) ++++.|+.++..... ..++..++.+|.+|+... ..+..++..|+ T Consensus 208 g~~~~L~~ll~~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~ 255 (651) T 3GQ2_A 208 NAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSY 255 (651) T ss_dssp THHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTC T ss_pred ChHHHHHHHHHHhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcCh Confidence 889999998875411 257888999999988644 44555555554 No 188 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=96.07 E-value=3.4e-05 Score=85.21 Aligned_cols=176 Identities=12% Similarity=0.192 Sum_probs=126.4 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSG--------------MSQLIGL-KEKGLPQIARLLQS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~--------------~~~~lli-e~giI~~Ll~LL~s 606 (747) ++..++++.|+.+|... .+..++..++.+|.+++...+. .. .....+. +.+.++.|+.++.+ T Consensus 56 ~v~~~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~ 133 (651) T 3GRL_A 56 EVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEE--EEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEE 133 (651) T ss_dssp HCCCCCHHHHHHHHHSCTTCHHHHHHHHHHHHHHHCCC----------------CHHHHHHHHHHHSTHHHHHHHHHTTC T ss_pred HHHccHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCCh--HhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccC Confidence 46778999999999731 3567788899999998864321 00 0012223 57888999999888 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHP--LLH-RVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS 682 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~--e~~-~ll-~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~ 682 (747) .++.++..++++|.+++... ... .++ ..++++.|+.+|.+ .+..++..++.+|.+++..+++....+... T Consensus 134 ~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~------~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~ 207 (651) T 3GRL_A 134 FDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLAD------SREVIRNDGVLLLQALTRSNGAIQKIVAFE 207 (651) T ss_dssp CCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGC------SSHHHHHHHHHHHHHHHTTCHHHHHHHHHT T ss_pred CCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHhC Confidence 88889999999999998773 222 233 45678889998876 367888999999999998555666666677 Q NP_000290.2 683 SMLNNIINLCRSSAS---PKAAEAARLLLSDMWSSK-ELQGVLRQQGF 726 (747) Q Consensus 683 giL~~Ll~LL~s~~d---~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~ 726 (747) ++++.|+.++..... ..++..++.+|.+|+... ..+..++..|+ T Consensus 208 g~~~~L~~ll~~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~ 255 (651) T 3GRL_A 208 NAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSY 255 (651) T ss_dssp THHHHHHHHHHHHTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTC T ss_pred ChHHHHHHHHHHhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcCh Confidence 889999998875411 257888999999988644 44555555554 No 189 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=96.03 E-value=3.4e-05 Score=69.70 Aligned_cols=112 Identities=26% Similarity=0.317 Sum_probs=74.8 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 135 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 214 (247) T 4V3Q_A 135 ALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 214 (247) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888899988876543333333344567777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..+. T Consensus 215 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 246 (247) T 4V3Q_A 215 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 246 (247) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHT T ss_pred HHcCHHHHHHHHHh-CChHHHHHHHHHHHHHHc Confidence 33456677777775 456677777777776653 No 190 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=96.03 E-value=3.5e-05 Score=79.51 Aligned_cols=136 Identities=16% Similarity=0.178 Sum_probs=85.8 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 245 ~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 324 (531) T 4TNM_A 245 PALPVLERLVQSMDEEVLTDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQM 324 (531) T ss_pred chHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 34555666666667778888889988887654433333344467777778787777788888999998887654333223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+..++....++.++..++.++..++... .....+.. ++++.|..++. T Consensus 325 ~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 382 (531) T 4TNM_A 325 VLDQQALPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQ 382 (531) T ss_pred HHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhc Confidence 3333566777777752235677888888888887643 22222222 45555555553 No 191 >4GMO_A Putative uncharacterized protein; ARM, HEAT, solenoid, nuclear transport; 2.1A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=95.93 E-value=5.4e-05 Score=85.22 Aligned_cols=94 Identities=14% Similarity=0.083 Sum_probs=69.0 Template_Neff=8.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLV-DLLRSPNQNVQQAAAGALRNLVFRS-TTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll-~lL~s~d~eVr~~AL~aLs~La~~~-~~~~ 322 (747) ..+..|+..|.+.++.++..++.+|.+++.. +.....+...++++.|+ .++.+.+..++..++.+|.+++... .... T Consensus 34 ~~i~~Li~~L~S~~~~~r~~A~~aL~~L~~d-~~~r~~l~~~g~i~~Li~~LL~d~~~~v~~~A~~aLrNLs~~~~~~~~ 112 (684) T 4GMO_A 34 DKILPVLKDLKSPDAKSRTTAAGAIANIVQD-AKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFC 112 (684) T ss_dssp CCCHHHHHHHSSSCCSHHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHCCCCCTTCSCHHHHHHHHHHHHHHHHHSCHHHH T ss_pred CChHHHHHHcCCCCHHHHHHHHHHHHHHhcC-HHHHHHHHHCChHHHHHHHHccCCCHHHHHHHHHHHHHHhccCChHHH Confidence 4566778888888888999999999998763 44555566678888888 8888878889999999999998652 2333 Q NP_000290.2 323 LETRRQNGIREAVSLLR 339 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ 339 (747) ..+...+++..|..++. T Consensus 113 ~~l~~~g~l~~L~~lL~ 129 (684) T 4GMO_A 113 VHLYRLDVLTAIEHAAK 129 (684) T ss_dssp HHHHHTTHHHHHHHHHH T ss_pred HHHHHCChHHHHHHHHH Confidence 34444566676666664 No 192 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=95.89 E-value=4.9e-05 Score=69.42 Aligned_cols=134 Identities=25% Similarity=0.295 Sum_probs=87.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 86 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 165 (281) T 4PLS_B 86 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 165 (281) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888888888876543333333344677777777777777888899999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 166 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 221 (281) T 4PLS_B 166 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 221 (281) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCcHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHcc Confidence 33456677777776 5567788888888888876422 2222222 56666666664 No 193 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=95.88 E-value=5e-05 Score=65.80 Aligned_cols=112 Identities=26% Similarity=0.298 Sum_probs=74.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 89 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (202) T 5MFO_F 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 168 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcChHHHHHHH Confidence 45556666666677788888999988876543333333344677777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 169 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 200 (202) T 5MFO_F 169 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKIQ 200 (202) T ss_dssp HHTTHHHHHHTTTT-CSSHHHHHHHHHHHHHHH T ss_pred HHCCHHHHHHHHHc-CCCHHHHHHHHHHHHHHH Confidence 33456666777775 446677777777776654 No 194 >2RU4_A Armadillo Repeat Protein, N-terminal fragment; solenoid repeat, Armadillo repeat motif; NMR {synthetic construct} Probab=95.88 E-value=5.2e-05 Score=59.81 Aligned_cols=110 Identities=25% Similarity=0.264 Sum_probs=70.0 Template_Neff=12.800 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR 327 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~ 327 (747) +.+...+...+..++..++.++..++.........+...+.++.+...+.+.++.++..++.++.+++.........+.. T Consensus 4 ~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~ 83 (115) T 2RU4_A 4 PQMTQQLNSDDMQEQLSATRKFSQILSDGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVID 83 (115) T ss_dssp CCCCCCCCCCCCCCCSCCCCCCCCCCCSCTTHHHHHCCSSSHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHHHT T ss_pred HHHHHhhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCchHHHHHHH Confidence 34455555556677888888888887654333333444456777777777667778888888888887554333333333 Q NP_000290.2 328 QNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 328 ~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .+.++.+...+. ..++.++..++.++.+++ T Consensus 84 ~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~ 113 (115) T 2RU4_A 84 AGALPALVQLLS-SPNEQILQEALWALSNIA 113 (115) T ss_dssp TTHHHHHHHGGG-SSCHHHHHHHHHHHHHHH T ss_pred CCcHHHHHHHhc-CCCHHHHHHHHHHHHHHh Confidence 456666666665 445667777777776654 No 195 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=95.87 E-value=5.1e-05 Score=69.48 Aligned_cols=114 Identities=26% Similarity=0.296 Sum_probs=74.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (286) T 5AEI_B 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (286) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677888889999988876544333333344567777777777777888889999988876433332233 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 160 (286) T 5AEI_B 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASG 160 (286) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HhCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 33446666666665 44566777777777776653 No 196 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=95.87 E-value=5.1e-05 Score=70.81 Aligned_cols=157 Identities=20% Similarity=0.303 Sum_probs=116.5 Template_Neff=13.300 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) +.++++.+..++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 128 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 201 (328) T 5MFD_C 128 DAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIAS 201 (328) T ss_dssp HTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHT T ss_pred HCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46777888899999998864332 22333456788888888888888899999999999987 Q NP_000290.2 625 H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) . ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++. T Consensus 202 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~ 274 (328) T 5MFD_C 202 GGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQ 274 (328) T ss_dssp SCHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCC-CHHHHH Confidence 6 222 233445677888888766 3677889999999999865555545555566788888888766 788899 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 275 ~a~~~l~~l~~~ 286 (328) T 5MFD_C 275 EALWTLGNIASG 286 (328) T ss_dssp HHHHHHHHHHTS T ss_pred HHHHHHHHHhCC Confidence 999999999865 No 197 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=95.87 E-value=5.2e-05 Score=65.68 Aligned_cols=112 Identities=26% Similarity=0.298 Sum_probs=74.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 89 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (202) T 5MFO_E 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 168 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 45556666666667788888899988876543333333344677777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 169 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 200 (202) T 5MFO_E 169 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKIQ 200 (202) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHC T ss_pred HHCCHHHHHHHHHc-CCCHHHHHHHHHHHHHHH Confidence 33456666777775 446677777777776654 No 198 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=95.85 E-value=5.5e-05 Score=74.91 Aligned_cols=158 Identities=19% Similarity=0.271 Sum_probs=114.4 Template_Neff=13.100 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDA-----TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~e-----Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) .+.++++.++.++.. .+.. ++..++.+|.+++..... ........++++.+..++.+.++.++..++.+ T Consensus 138 ~~~~~~~~l~~~l~~-~~~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~ 211 (466) T 5D5K_C 138 IKHGAIDPLLALLAV-PDLSTLACGYLRNLTWTLSNLCRNKNP-----APPLDAVEQILPTLVRLLHHNDPEVLADSCWA 211 (466) T ss_dssp HHTTCHHHHHHTTCS-SCGGGSCHHHHHHHHHHHHHHSCCCSS-----CCCHHHHHHHHHHHHHHTTSSCHHHHHHHHHH T ss_pred HHCCcHHHHHHHhhC-CCcccccHHHHHHHHHHHHHHHcCCCC-----CCChHHHHHHHHHHHHHHcCCCHHHHHHHHHH Confidence 355667777777763 3333 677888888888765322 11121225678888888888888899999999 Q NP_000290.2 619 LSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. T Consensus 212 l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 284 (466) T 5D5K_C 212 ISYLTDGPNERIEMVVKKGVVPQLVKLLGA------TELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP- 284 (466) T ss_dssp HHHHTSSCHHHHHHHHTTTCHHHHHHHHTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTGGGGHHHHTTCS- T ss_pred HHHHhcCCchHHHHHHHCChHHHHHHHhcC------CCchHHHHHHHHHHHHhcCCHHHHHHHHccChhHhHHHHhhCC- Confidence 999987632 2 233455677888888876 3678889999999999876455555566667888888888766 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|.+++.. T Consensus 285 ~~~v~~~a~~~l~~l~~~ 302 (466) T 5D5K_C 285 KTNIQKEATWTMSNITAG 302 (466) T ss_dssp SHHHHHHHHHHHHHHTTS T ss_pred CHHHHHHHHHHHHHHHcC Confidence 788899999999998875 No 199 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=95.84 E-value=5.9e-05 Score=71.37 Aligned_cols=116 Identities=18% Similarity=0.237 Sum_probs=80.5 Template_Neff=11.900 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++... +..++..++.++.+++.........+...+.++.+..++...+..++..++.++.+++......... T Consensus 109 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~ 188 (280) T 1XQS_B 109 ALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGT 188 (280) T ss_dssp HHHHHHHHHHSCSCHHHHHHHHHHHHHTTSSCHHHHHHHHTTTHHHHHHHHHTSSCHHHHHHHHHHHHHHHHHCGGGHHH T ss_pred HHHHHHHHhccCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 455566666654 6778888999999988654433334444567777888777667778888999999888654423333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...++++.+..++. ..++.++..++.++.+++.... T Consensus 189 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~ 225 (280) T 1XQS_B 189 LCSMGMVQQLVALVR-TEHSPFHEHVLGALCSLVTDFP 225 (280) T ss_dssp HHTTTHHHHHHHHHT-SSCCTTHHHHHHHTTTSSTTCH T ss_pred HHhCCHHHHHHHHHc-CCCcHHHHHHHHHHHHHHhcCH Confidence 444467777777776 5567788888999998887543 No 200 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=95.82 E-value=5.9e-05 Score=74.70 Aligned_cols=158 Identities=19% Similarity=0.271 Sum_probs=114.6 Template_Neff=13.100 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDA-----TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~e-----Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) .+.++++.++.++.. .+.. ++..++.+|.+++..... ........++++.+..++.+.++.++..++.+ T Consensus 138 ~~~~~~~~l~~~l~~-~~~~~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~ 211 (466) T 4UAF_B 138 IKHGAIDPLLALLAV-PDLSTLACGYLRNLTWTLSNLCRNKNP-----APPLDAVEQILPTLVRLLHHNDPEVLADSCWA 211 (466) T ss_pred HHCCcHHHHHHHhhC-CCcccccHHHHHHHHHHHHHHHcCCCC-----CCChhHHHHHHHHHHHHHcCCCHHHHHHHHHH Confidence 355667777777763 3333 677888888888865332 11121225678888888888888999999999 Q NP_000290.2 619 LSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. T Consensus 212 l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 284 (466) T 4UAF_B 212 ISYLTDGPNERIEMVVKKGVVPQLVKLLGA------TELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP- 284 (466) T ss_pred HHHHhcCCcHHHHHHHHCChHHHHHHHhcC------CChhHHHHHHHHHHHHhcCCHHHHHHHhccCHHHHHHHHhcCC- Confidence 999987632 2 233455678888888876 3678889999999999876455555566667888888888766 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|.+++.. T Consensus 285 ~~~v~~~a~~~l~~l~~~ 302 (466) T 4UAF_B 285 KTNIQKEATWTMSNITAG 302 (466) T ss_pred CHHHHHHHHHHHHHHhcC Confidence 788899999999999875 No 201 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=95.82 E-value=6.4e-05 Score=72.71 Aligned_cols=116 Identities=18% Similarity=0.237 Sum_probs=81.0 Template_Neff=11.300 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++... ++.++..++.++.+++.........+...++++.+...+...+..++..++.++.+++......... T Consensus 125 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~ 204 (296) T 1XQR_A 125 ALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGT 204 (296) T ss_dssp HHHHHHHHHHHCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHCGGGHHH T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 455566666654 6778889999999998754433334444567777887777667788888999999888754433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...++++.+..++. ..++.++..++.+|.+++.... T Consensus 205 ~~~~~~i~~L~~ll~-~~~~~~~~~a~~~L~~l~~~~~ 241 (296) T 1XQR_A 205 LCSMGMVQQLVALVR-TEHSPFHEHVLGALCSLVTDFP 241 (296) T ss_dssp HHHTTHHHHHHHHHT-SCCSTHHHHHHHHHHHHHTTCH T ss_pred HHhCCHHHHHHHHHc-CCChHHHHHHHHHHHHHHhcCH Confidence 444567777777776 4566788888899988887543 No 202 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=95.81 E-value=6.2e-05 Score=78.24 Aligned_cols=151 Identities=10% Similarity=0.021 Sum_probs=91.7 Template_Neff=12.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ---SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~---s~d~eVr~~AL~aLsnLa 623 (747) ..++.|+.++. +.+..++..++.++..+....+. ....+++.+...+. ..+..++ .++++|+.+. T Consensus 414 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~~~r-~a~~~l~~~~ 481 (585) T 6CRI_R 414 WHIDTIMRVLT-TAGSYVRDDAVPNLIQLITNSVE----------MHAYTVQRLYKAILGDYSQQPLVQ-VAAWCIGEYG 481 (585) T ss_pred HHHHHHHHHHH-HhccccCccHHHHHHHHHhcCch----------HHHHHHHHHHHHHHCCCCCHHHHH-HHHHHHHHHH Confidence 35566666666 35566777777777777653211 11234555666653 3344556 7888888877 Q NP_000290.2 624 RHPLLH--------RVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 624 ~~~e~~--------~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) ...... ......+++.|..++ .+ .+..++..++.+|..+....+. ....++..+..++. T Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~L~~~l~~~~------~~~~vr~~a~~al~~l~~~~~~-----~~~~~~~~l~~~~~ 550 (585) T 6CRI_R 482 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNM------STSVTRGYALTAIMKLSTRFTC-----TVNRIKKVVSIYGS 550 (585) T ss_pred HHhcCCCCCCCCCCCCCHHHHHHHHHHHhcccC------CCHHHHHHHHHHHHHHHhcCCc-----hHHHHHHHHHHHcc Confidence 642110 111234566666666 33 3567888999999998875332 22234555666666 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKELQGVL 721 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~~~~~~ 721 (747) +. ++.++..++.++..+..+......+ T Consensus 551 ~~-~~~vr~~a~~~l~~l~~~~~~~~~l 577 (585) T 6CRI_R 551 SI-DVELQQRAVEYNALFKKYDHMRSAL 577 (585) T ss_pred CC-CHHHHHHHHHHHHHhhhHHHHHHHH Confidence 65 7889999999999988765544443 No 203 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=95.78 E-value=6.8e-05 Score=80.44 Aligned_cols=136 Identities=26% Similarity=0.298 Sum_probs=92.6 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.+|.+++...+.....+...++++.+..++.+.++.++..++.++..++......... T Consensus 262 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 341 (671) T 6SA8_A 262 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQA 341 (671) T ss_dssp TCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHhChHHHHHHHhcCCcHHHHHHHHHHHHHHhcCCcHHHHH Confidence 34556666666677788889999999887654333334444567788888888777888889999999987654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) +...++++.+...+. ..++.++..++.++..++.. ......+.. ++++.|+.++.. T Consensus 342 ~~~~~~l~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 399 (671) T 6SA8_A 342 VIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSS 399 (671) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcCcHHHHHHHhcC Confidence 334456777777776 55677888899999998873 332333333 677777776653 No 204 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=95.77 E-value=8.1e-05 Score=89.51 Aligned_cols=168 Identities=12% Similarity=0.072 Sum_probs=120.9 Template_Neff=8.700 Q NP_000290.2 541 GWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASL 618 (747) Q Consensus 541 ~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~a 618 (747) ..+...|+++.++.+|. +..++++..++.++.+++..++. .+..+.+.+++..|+.+|... .+.++..++.+ T Consensus 500 ~~~~~~gi~p~ll~lL~-s~~~~lr~~a~~i~a~i~~~d~~-----~q~~l~~~~~l~~ll~~L~~~~~~~~~r~~a~~~ 573 (1287) T 5WBJ_A 500 DLALSVGIFPYVLKLLQ-TTTNELRQILVFIWTKILALDKS-----CQIDLVKDGGHTYFIRFLDSSGAFPEQRAMAAFV 573 (1287) T ss_dssp HHHHHHTCHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHTTCHHHHHHHHHCSSCCHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH-----HHHHHHHcCCeeeEEEeecCCCCCHHHHHHHHHH Confidence 33457789999999998 47788899999999999876443 344556677888899988743 35567788999 Q NP_000290.2 619 LSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTG-NTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 619 LsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~-~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) |+.++.. ... ..+...+++..+...|..... ....++.++..++.+|..|+...+.........+++..|+.+|.+. T Consensus 574 Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~~~~lr~~a~~~L~~L~~~~~~~~~~~~~~~~~~~L~~lL~~~ 653 (1287) T 5WBJ_A 574 LAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQPEPLFLQWLCLCLGKLWEDFMEAQIMGREANAFEKLAPLLSEP 653 (1287) T ss_dssp HHHHHTTCHHHHHHHHHTTHHHHHHHHCC---------CHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHGGGGGCS T ss_pred HHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhccHHHHHHHHHcCHHHHHHHHhcCC Confidence 9999876 222 233444677777777761000 0003678899999999999877555555556667788899999877 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.++.+++.+|+.++... T Consensus 654 -~~~VRaaal~aL~~li~~~ 672 (1287) T 5WBJ_A 654 -QPEVRAAAVFALGTLLDIG 672 (1287) T ss_dssp -CHHHHHHHHHHHHHTCC-- T ss_pred -CHHHHHHHHHHHHHHHhcC Confidence 8899999999999998764 No 205 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=95.74 E-value=7.4e-05 Score=71.65 Aligned_cols=115 Identities=17% Similarity=0.172 Sum_probs=76.4 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQD----EKYQAIGAYYIQHTCF---QDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd----~eVr~sAL~aLsnLs~---~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+..++...+ ..++..++.++.++.. ........+...++++.+..++...++.++..++.++.+++... T Consensus 210 ~~~~l~~~l~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~ 289 (339) T 5Z8H_A 210 ALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARN 289 (339) T ss_pred hHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHHhhccCHHHHHHHHHCCHHHHHHHHHhCCCHHHHHHHHHHHHHHhCCC Confidence 4445555554332 5677778888887752 22223333334467777788787777788889999999988744 Q NP_000290.2 319 TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 319 ~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) +.....+...++++.+..++. ..++.++..++.++.+++... T Consensus 290 ~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~ 331 (339) T 5Z8H_A 290 PKDQEALWDMGAVSMLKNLIH-SKHKMIAMGSAAALRNLMANR 331 (339) T ss_pred HHHHHHHHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCC Confidence 443344444567788888886 556778888999998888643 No 206 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=95.72 E-value=9.2e-05 Score=89.00 Aligned_cols=168 Identities=12% Similarity=0.072 Sum_probs=120.7 Template_Neff=8.700 Q NP_000290.2 541 GWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASL 618 (747) Q Consensus 541 ~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~a 618 (747) ..+...|+++.|+++|. +..++++..++.++.+++..++. .+..+.+.+++..|+.+|... .+.++..++.+ T Consensus 500 ~~~l~~Gi~p~ll~lL~-s~~~~lr~~a~~i~a~i~~~d~~-----~q~~l~~~~~l~~ll~~L~~~~~~~~~r~~a~~~ 573 (1287) T 5WBK_A 500 DLALSVGIFPYVLKLLQ-TTTNELRQILVFIWTKILALDKS-----CQIDLVKDGGHTYFIRFLDSSGAFPEQRAMAAFV 573 (1287) T ss_dssp HHHHHHTCHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHTTTHHHHHHHHHSSCCCHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH-----HHHHHHHcCCeeeEEEeecCCCCCHHHHHHHHHH Confidence 33457789999999998 46778899999999999876443 344456677888899988743 35567788899 Q NP_000290.2 619 LSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTG-NTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 619 LsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~-~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) |+.++.. ... ..+...+++..+...|..... ....++.++..++.+|+.|+...+.........+++..|+.+|.+. T Consensus 574 Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~~~~lr~~a~~~L~~L~~~~~~~~~~~~~~~~~~~L~~lL~~~ 653 (1287) T 5WBK_A 574 LAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQPEPLFLQWLCLCLGKLWEDFMEAQIMGREANAFEKLAPLLSEP 653 (1287) T ss_dssp HHHHHTTCHHHHHHHHHTTHHHHHHHHCC---------CHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHGGGGGCS T ss_pred HHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHcccHHHHHHHHHCCHHHHHHHHhcCC Confidence 9999876 222 233444677777777761000 0003678899999999999876555555556667788899999877 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+|.+++.+|+.++... T Consensus 654 -~~~VRaaal~AL~~li~~~ 672 (1287) T 5WBK_A 654 -QPEVRAAAVFALGTLLDIG 672 (1287) T ss_dssp -CHHHHHHHHHHHHHHCC-- T ss_pred -CHHHHHHHHHHHHHHHhcC Confidence 8899999999999998764 No 207 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=95.69 E-value=8.4e-05 Score=73.16 Aligned_cols=135 Identities=25% Similarity=0.260 Sum_probs=92.1 Template_Neff=12.400 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+..++.+.++.++..++.+|.+++.........+...++++.+..++...++.++..++.+|..++......... T Consensus 241 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 320 (397) T 6SA6_A 241 GALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQA 320 (397) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHHhCChHHHHHHHhcCCcHHHHHHHHHHHHHHhcCcHHHHHH Confidence 34566666777777888889999999987654333333444467777888887777788888899998887654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+..++. ..++.++..++.++..++.. ......+.. ++++.|..++. T Consensus 321 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 377 (397) T 6SA6_A 321 VIDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQS 377 (397) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCchHHHHHHHh Confidence 444567777888776 55678888899999998874 333333333 67777777664 No 208 >2W3C_A GENERAL VESICULAR TRANSPORT FACTOR P115; MEMBRANE VESICLE TETHERING, ARMADILLO FOLD; HET: PEG; 2.22A {HOMO SAPIENS} Probab=95.59 E-value=0.00012 Score=79.14 Aligned_cols=136 Identities=15% Similarity=0.146 Sum_probs=91.0 Template_Neff=10.400 Q NP_000290.2 246 TIPKAVQYLSSQ--DEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQQ 305 (747) Q Consensus 246 iL~~Ll~lL~ss--d~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr~ 305 (747) .++.++..+.+. +..+...++.+|..++..... ....+. ..+.++.++.++.+.+..++. T Consensus 9 ~l~~Li~~L~~~~~~~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~v~~ 88 (577) T 2W3C_A 9 AMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRW 88 (577) T ss_dssp TTHHHHHHHHHCTTCHHHHHHHHHHHHHHHHC------------------CHHHHHHHHSTHHHHHHHHHTTCCCHHHHH T ss_pred hHHHHHHHHhhCCCcHHHHHHHHHHHHHHhCCCchhhhhhccccccHHHHHHHHHHHHhcCchHHHHHHHccCCCHHHHH Confidence 345566666543 456778888888888765431 122233 456777788888777788899 Q NP_000290.2 306 AAAGALRNLVFRST-TNKLETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVII 381 (747) Q Consensus 306 ~AL~aLs~La~~~~-~~~~~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~ 381 (747) .++.+|..++...+ .....+. ..+.++.++.++. ..+..++..++.+|.+++... .....+.. ++++.|+.++.. T Consensus 89 ~a~~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~g~~~~L~~ll~~ 167 (577) T 2W3C_A 89 PGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISE 167 (577) T ss_dssp HHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHH T ss_pred HHHHHHHHHHHhchHHHHHHHHhCCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHcCCHHHHHHHHHHH Confidence 99999999886543 2222333 2467888888886 556788999999999998743 33333333 889999988875 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 168 ~ 168 (577) T 2W3C_A 168 E 168 (577) T ss_dssp T T ss_pred h Confidence 3 No 209 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=95.58 E-value=0.0001 Score=74.75 Aligned_cols=106 Identities=11% Similarity=0.025 Sum_probs=69.8 Template_Neff=13.200 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.+..++..++.++..+.... ....+++.+...+.+.++.++..++.++..+......... T Consensus 72 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~~~~ 144 (570) T 6CRI_I 72 IMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVE 144 (570) T ss_dssp GTTHHHHHHHTSSSCHHHHHHHHHHHHHCCCTT-------TTTTSHHHHHHHHTCSSHHHHHHHHHHHHHHHHHCHHHHH T ss_pred HHHHHHHHHHcCCCCHHHHHHHHHHHccCChhH-------HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhChhhhh Confidence 344555666666677778888888887775321 1123556666667777788888899988888754332211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. +.++.++..++.++..+... T Consensus 145 ---~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~ 177 (570) T 6CRI_I 145 ---DQGFLDTLKDLIS-DSNPMVVANAVAALSEIAES 177 (570) T ss_dssp ---HHTHHHHHHHHHT-SSSHHHHHHHHHHHHHHHHH T ss_pred ---ccchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhh Confidence 1345666677776 56778888899888888764 No 210 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=95.57 E-value=0.00011 Score=79.31 Aligned_cols=157 Identities=12% Similarity=0.081 Sum_probs=97.3 Template_Neff=13.200 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.+|..++...+. ....+ -..+++.+...+.+.+..++..++.++..++... T Consensus 667 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 739 (890) T 1QBK_B 667 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKPC-IADFMPILGTNLNPEFISVCNNATWAIGEISIQM 739 (890) T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhHH-----hHHHH-HHHHHHHHHhhcCcccHHHHHHHHHHHHHHHHHc Confidence 35566666666 36778888899999988764321 11111 1346667777777777889999999999988652 Q NP_000290.2 627 -LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 -e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .........+++.+...+.+. ..+..++..++.+|+.++...+....... ..++..++..+....++.++..++ T Consensus 740 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~ 814 (890) T 1QBK_B 740 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 814 (890) T ss_pred CccccchHHHHHHHHHHHHcCC----CCCccHHHHHHHHHHHHHhhCHHhHHHHH-HHhHHHHHHHHhcCCChHHHHHHH Confidence 211112234566677766541 01567888999999998875332211111 234555666555432567788888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..+.... T Consensus 815 ~~l~~l~~~~ 824 (890) T 1QBK_B 815 RGICTMISVN 824 (890) T ss_pred HHHHHHHhhC Confidence 8888776543 No 211 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=95.56 E-value=0.00012 Score=77.66 Aligned_cols=151 Identities=10% Similarity=0.027 Sum_probs=89.9 Template_Neff=12.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ---SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~---s~d~eVr~~AL~aLsnLa 623 (747) ..++.|+.++. +.++.++..++.+|..+....+. ....+++.+...+. ..+..++ .++++|+.+. T Consensus 431 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~~~r-~a~~~l~~~~ 498 (627) T 4P6Z_G 431 WHIDTIMRVLT-TAGSYVRDDAVPNLIQLITNSVE----------MHAYTVQRLYKAILGDYSQQPLVQ-VAAWCIGEYG 498 (627) T ss_dssp HHHHHHHHHHH-HTGGGSCGGGHHHHHHHHHSCTT----------TTHHHHHHHHHHHHHCCCSHHHHH-HHHHHHHHTH T ss_pred HHHHHHHHHHH-hhccccCcchHHHHHHHHhcCch----------HHHHHHHHHHHHHHcCCCCHHHHH-HHHHHHHHHH Confidence 35566666665 35566677777777776643211 01234455555553 2334555 7778887776 Q NP_000290.2 624 RHPLL-H-------RVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 624 ~~~e~-~-------~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) ..... . ......+++.|..++ .+ .++.++..++.+|..+....+. ....++..|..++. T Consensus 499 ~~~~~~~~~~~~~~~~~~~~~~~~L~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~-----~~~~~~~~l~~~~~ 567 (627) T 4P6Z_G 499 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNM------STSVTRGYALTAIMKLSTRFTC-----TVNRIKKVVSIYGS 567 (627) T ss_dssp HHHHSCCCTTSCCCCCCSHHHHHHHHHHHHCTT------CCHHHHHHHHHHHHHHHHHCCS-----CHHHHHHHHHHGGG T ss_pred HHhccCCCCCCCCCCCCHHHHHHHHHHHHcccC------CCHHHHHHHHHHHHHHHhhccc-----hHHHHHHHHHHHcc Confidence 54111 0 011124566666666 33 3567889999999998865332 22234566666666 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKELQGVL 721 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~~~~~~ 721 (747) +. +..++..++.++..+..+......| T Consensus 568 ~~-~~~vr~~a~~~l~~l~~~~~~~~~l 594 (627) T 4P6Z_G 568 SI-DVELQQRAVEYNALFKKYDHMRSAL 594 (627) T ss_dssp CS-CHHHHHHHHHHHHHHHHCTTHHHHH T ss_pred CC-CHHHHHHHHHHHHHhhhHHHHHHHH Confidence 65 7889999999999988764444443 No 212 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=95.46 E-value=0.00014 Score=65.05 Aligned_cols=112 Identities=20% Similarity=0.227 Sum_probs=75.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 131 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 210 (243) T 5MFI_B 131 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 210 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666667788888889888876544333333444577778888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 211 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 242 (243) T 5MFI_B 211 EEAGAEPALEKLQS-SPNEEVQKNAQAALEALN 242 (243) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHC T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHhc Confidence 33456667777775 456677777777777654 No 213 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=95.46 E-value=0.00014 Score=65.05 Aligned_cols=112 Identities=20% Similarity=0.227 Sum_probs=75.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 131 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 210 (243) T 5MFJ_B 131 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 210 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666667788888889888876544333333444577778888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 211 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 242 (243) T 5MFJ_B 211 EEAGAEPALEKLQS-SPNEEVQKNAQAALEALN 242 (243) T ss_dssp HHTTHHHHHHHTSS-CSCHHHHHHHHHHHHHHC T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHhc Confidence 33456667777775 456677777777777654 No 214 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=95.43 E-value=0.00015 Score=67.32 Aligned_cols=134 Identities=16% Similarity=0.127 Sum_probs=89.1 Template_Neff=11.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+..++...+..++..++.++.+++.........+...+.++.++.++...+..++..++.++.+++.........+ T Consensus 87 ~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 166 (252) T 5EWP_B 87 GIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMKSNIDGMKAACAQTCRNIFVLDKKYKKEF 166 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 45556666666667788889999999887544444445555677888888877677888999999999876533333344 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNA-------EIQKQLTGLLWNLSSTDEL-----KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~-------eVr~~AL~aLsnLas~~~~-----~~~Lve-giLe~Lv~LL~ 380 (747) ...+.++.+..++. .... .++..++.++..++..... ...+.. ++++.|..++. T Consensus 167 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~L~~~l~ 233 (252) T 5EWP_B 167 LKLGGITQLVNLLE-LPSNYDDSQPLYTQLEAIYHLEDFILNDGDEIPEFLEAVKNSNSIKNLKTLQQ 233 (252) T ss_dssp HHTTHHHHHHHTTS-CCTTCCSCSCCHHHHHHHHHHHHHHEETTEECHHHHHHHHTTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCCCCCCchHHHHHHHHHHHHHHHhcCCCccHHHHHHHHhCChHHHHHHHhh Confidence 44567777777775 3333 2777788888888764331 223333 66777777663 No 215 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=95.36 E-value=0.00017 Score=64.82 Aligned_cols=134 Identities=25% Similarity=0.303 Sum_probs=88.0 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 51 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 130 (247) T 4V3Q_A 51 ALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAV 130 (247) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666766677888889999998876544333334445677788888877778888889999988875443333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 131 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 186 (247) T 4V3Q_A 131 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLS 186 (247) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhc Confidence 34466777777776 4566778888888888876432 2222222 55666665554 No 216 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=95.28 E-value=0.00022 Score=78.31 Aligned_cols=135 Identities=13% Similarity=0.116 Sum_probs=92.0 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQ-QVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~-~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++...+..++..++.+|..++...+.... .+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 123 ~i~~Ll~ll~~~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~i~~~a~~~L~~l~~~~~~~~~ 202 (651) T 3GQ2_A 123 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 202 (651) T ss_dssp HHHTHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHH Confidence 455566666666778889999999998865432221 222 345778888888877778889999999999874444434 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~ 381 (747) .+...+.++.++.++. ... ..++..++.+|.+++........ +.+ ++++.|+.+|.. T Consensus 203 ~l~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~i~~L~~lL~~ 265 (651) T 3GQ2_A 203 IVAFENAFERLLDIIT-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 265 (651) T ss_dssp HHHHTTHHHHHHHHHH-HTTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGTGGGGCC T ss_pred HHHhCChHHHHHHHHH-HhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcChHHHHHHHHhc Confidence 4445577888888876 322 25777888899998875433333 334 788888888864 No 217 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=95.28 E-value=0.00022 Score=78.31 Aligned_cols=135 Identities=13% Similarity=0.116 Sum_probs=92.0 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQ-QVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~-~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++...+..++..++.+|..++...+.... .+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 123 ~i~~Ll~ll~~~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~i~~~a~~~L~~l~~~~~~~~~ 202 (651) T 3GRL_A 123 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 202 (651) T ss_dssp HHHHHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHH Confidence 455566666666778889999999998865432221 222 345778888888877778889999999999874444434 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~ 381 (747) .+...+.++.++.++. ... ..++..++.+|.+++........ +.+ ++++.|+.+|.. T Consensus 203 ~l~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~i~~L~~lL~~ 265 (651) T 3GRL_A 203 IVAFENAFERLLDIIT-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 265 (651) T ss_dssp HHHHTTHHHHHHHHHH-HHTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGGGGGGCC T ss_pred HHHhCChHHHHHHHHH-HhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcChHHHHHHHHhc Confidence 4445577888888876 322 25777888899998875433333 334 788888888864 No 218 >5AFF_A SYMPORTIN 1, RIBOSOMAL PROTEIN L5; CHAPERONE, RIBOSOME BIOGENESIS, ALPHA SOLENOID.; 3.398A {CHAETOMIUM THERMOPHILUM} Probab=95.22 E-value=0.00026 Score=78.85 Aligned_cols=94 Identities=14% Similarity=0.083 Sum_probs=66.2 Template_Neff=8.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLV-DLLRSPNQNVQQAAAGALRNLVFRS-TTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll-~lL~s~d~eVr~~AL~aLs~La~~~-~~~~ 322 (747) ..++.|+..+.+.++..+..++.+|.+++.. +.....+...++++.|+ .++.+.+..++..++.+|.+++... .... T Consensus 12 ~~i~~Li~~L~s~~~~~r~~A~~aL~~L~~d-~~~r~~ll~~g~v~~Li~~lL~d~~~~v~~~a~~aLrnLs~~~~~~~~ 90 (654) T 5AFF_A 12 DKILPVLKDLKSPDAKSRTTAAGAIANIVQD-AKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFC 90 (654) T ss_dssp HHHHHHHHHHHSSCTTHHHHHHHHHHHHHCC-HHHHHHHHHTTHHHHHHHTGGGCSSHHHHHHHHHHHHHHHHHSCHHHH T ss_pred CchHHHHHHcCCCCHHHHHHHHHHHHHHHcC-HHHHHHHHHCChHHHHHHHHccCCCHHHHHHHHHHHHHHhccCchhHH Confidence 3456677777777888899999999998754 44444555567888887 7787777889999999999997643 2222 Q NP_000290.2 323 LETRRQNGIREAVSLLR 339 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ 339 (747) ..++..+++..|..++. T Consensus 91 ~~l~~~~il~~L~~lL~ 107 (654) T 5AFF_A 91 VHLYRLDVLTAIEHAAK 107 (654) T ss_dssp HHHHHTTHHHHHHHHHH T ss_pred HHHHHCChHHHHHHHHH Confidence 33444566666666654 No 219 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=95.19 E-value=0.00023 Score=72.97 Aligned_cols=107 Identities=12% Similarity=0.043 Sum_probs=72.0 Template_Neff=12.900 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ...+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 84 ~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~ 156 (592) T 6QH5_B 84 AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMV 156 (592) T ss_pred HHHHHHHHHHHccCCCHHHHHHHHHHHHHHcchh-------hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCchhh Confidence 4445666666777777888888888888775421 112355666666777778889999999888875433211 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 157 ---~~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~~~~~ 190 (592) T 6QH5_B 157 ---EDQGFLDSLRDLIA-DSNPMVVANAVAALSEISES 190 (592) T ss_pred ---cCccHHHHHHHHhC-CCCHHHHHHHHHHHHHHHhc Confidence 11245666666675 55678888899988888764 No 220 >3C2G_A Sys-1 protein, Pop-1 8-residue peptide; beta-catenin, phylogeny, SYS-1, POP-1, Caenorhabditis; HET: MSE; 2.5A {Caenorhabditis elegans} Probab=95.17 E-value=0.00033 Score=77.69 Aligned_cols=189 Identities=17% Similarity=0.156 Sum_probs=108.5 Template_Neff=5.600 Q NP_000290.2 260 KYQAIGAYYIQHTCFQDESAKQQVYQL-GG----------ICKLVDLLRSP----------------N----QNVQQAAA 308 (747) Q Consensus 260 eVr~sAL~aLsnLs~~~~~~~~~li~~-~I----------L~~Ll~lL~s~----------------d----~eVr~~AL 308 (747) .+...++.++..++..+......+... +. +..|+.++... + +.+...+. T Consensus 185 ~~~~~i~d~Lr~L~~~n~~~K~~~l~~~g~~~~~~~~~~~I~~Ll~IL~~~~~~~~~~~~e~~~~~~~~~~~e~ll~~t~ 264 (619) T 3C2G_A 185 MINPAIFIIFRFIISKDTRLKDYFIWNNNPHDQPPPPTGLIIKLNAVMIGSYRLIAGQNPETLPQNPELAHLIQVIIRTF 264 (619) T ss_dssp GCCTHHHHHHHHHHTTCHHHHHHHHHTTCCTTSCCCTTSHHHHHHHHHHHHHHHHTTCCGGGGGGCHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHhcCCHHHHHHHHhcCCCCCCCCCCchHHHHHHHHHHHhHhhhcCCCcccCCCCccHHHHHHHHHHHH Confidence 344556667777766544443333332 23 56676666531 1 44555666 Q NP_000290.2 309 GALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 388 (747) Q Consensus 309 ~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~ 388 (747) .+|..+. ........+...+.++.|...+. ..++.+...++++|.++.........-+++.+..++.+|.. T Consensus 265 ~lLk~Ls-~~sn~a~~~V~~gGvq~L~~~L~-~~S~rlv~~~L~~LrnlSDa~~~~~~~l~~ll~~lv~ll~~------- 335 (619) T 3C2G_A 265 DLLGLLL-HDSDAIDGFVRSDGVGAITTVVQ-YPNNDLIRAGCKLLLQVSDAKALAKTPLENILPFLLRLIEI------- 335 (619) T ss_dssp HHHHHHC-CSHHHHHHHHHTTHHHHHHHHTT-SSCHHHHHHHHHHHHHHTTCGGGGTSCCTTHHHHHHHHHHH------- T ss_pred HHHHHHh-CCcchHHHHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHchHHHcCCchHHHHHHHHHHHhc------- Confidence 7777666 33333345666788888888886 67788999999999999865432212223566667776621 Q NP_000290.2 389 GNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAA---- 464 (747) Q Consensus 389 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---- 464 (747) .-|+.+..-+||+|..-. ....--+.+---.|-|+.|+.-+..+... T Consensus 336 --------~~D~~iv~~~tG~LsNlt---------------------~nn~~NK~~~i~~ggi~~Li~~i~~~~~~~~~~ 386 (619) T 3C2G_A 336 --------HPDDEVIYSGTGFLSNVV---------------------AHKQHVKDIAIRSNAIFLLHTIISKYPRLDELT 386 (619) T ss_dssp --------CCCHHHHHHHHHHHHHHS---------------------TTCHHHHHHHHHTTHHHHHHHHHHTSCCGGGCC T ss_pred --------CCCHHHHHHHHHHHHHHH---------------------cCChhHHHHHHhCCHHHHHHHHHHhCCccccCC Confidence 237888888898875311 11111111111234445555444333210 Q NP_000290.2 465 ----SRCDDKSVENCMCVLHNLSYRL 486 (747) Q Consensus 465 ----~~~~~~~~~~~~~~~~~~~~~~ 486 (747) -+-...-.|||.|.|+||..+- T Consensus 387 ~~~~~~~~eeI~e~~l~aLr~Lt~~h 412 (619) T 3C2G_A 387 DAPKRNRVCEIICNCLRTLNNFLMMW 412 (619) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHGGG T ss_pred CCchhhhhHHHHHHHHHHHHHHhccC Confidence 0011345899999999998874 No 221 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=95.09 E-value=0.00028 Score=75.31 Aligned_cols=157 Identities=12% Similarity=0.083 Sum_probs=93.3 Template_Neff=13.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..++...+. ..... -..+++.+...+.+.+..++..++.++..++.. T Consensus 629 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 701 (852) T 4FDD_A 629 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKPC-IADFMPILGTNLNPEFISVCNNATWAIGEISIQM 701 (852) T ss_dssp CHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCGG-----GTGGG-HHHHHHHHHHTCCTTSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHHHH-----hHHHH-HHHHHHHHHhhCCcccHHHHHHHHHHHHHHHHHc Confidence 35566666666 35677888899999988764321 11111 134666677777777788888999999888765 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.+...+... ..+..++..++.+|..+....+....... ..++..++..+....+..++..++ T Consensus 702 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~a~ 776 (852) T 4FDD_A 702 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 776 (852) T ss_dssp GGGGGGGTHHHHHHHHHHHTCS----SCCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHHTSCSSHHHHHHH T ss_pred CccchhhHHHHHHHHHHHHcCC----CCChhHHHHHHHHHHHHHHHCHHHhHHHH-HHhHHHHHHHhhcCCCHHHHHHHH Confidence 2111111123556666666541 01467788888999888765332111111 124445555554322567788888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 777 ~~l~~l~~~~ 786 (852) T 4FDD_A 777 RGICTMISVN 786 (852) T ss_dssp HHHHHHHHHC T ss_pred HHHHHHHhhC Confidence 8887776543 No 222 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=95.03 E-value=0.00031 Score=72.53 Aligned_cols=106 Identities=11% Similarity=0.035 Sum_probs=69.9 Template_Neff=12.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 101 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~- 172 (600) T 4P6Z_B 101 IMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLV- 172 (600) T ss_pred HHHHHHHHHHccCCCHHHHHHHHHHHhcCCchH-------HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhhChHHh- Confidence 344555566666667788888888887775321 112455666666777778888889998888875433211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 173 --~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 206 (600) T 4P6Z_B 173 --EDQGFLDTLKDLIS-DSNPMVVANAVAALSEIAES 206 (600) T ss_pred --hccChHHHHHHHhc-CCCHHHHHHHHHHHHHHHhh Confidence 11345666777775 55678888888888888764 No 223 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=95.01 E-value=0.00032 Score=73.46 Aligned_cols=144 Identities=13% Similarity=0.048 Sum_probs=89.0 Template_Neff=12.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~ 624 (747) ..++.|+.++. +.+..++..++.++..+...... ....+++.|...+.+.+.. ++..++++|+.+.. T Consensus 441 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~v~~~a~~~l~~~~~ 509 (623) T 2JKT_A 441 WYVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGN 509 (623) T ss_dssp HHHHHHHHHTT-TTGGGCCHHHHHHHHHHHHHCST----------THHHHHHHHHHHTTSSSCCHHHHHHHHHHHHHSST T ss_pred HHHHHHHHHHH-HHcccCCHHHHHHHHHHHhcChh----------HHHHHHHHHHHHHhCccCCHHHHHHHHHHHHHHHH Confidence 35666777776 35566777788888777653211 1234566666666655544 78888888888775 Q NP_000290.2 625 HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKA 700 (747) Q Consensus 625 ~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eV 700 (747) .... .......+++.|...+.+ .+..++..++.+|..++...+. . ...+..++..+ .+. ++.+ T Consensus 510 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~al~~l~~~~~~-----~-~~~l~~ll~~l~~~~~~-~~~v 576 (623) T 2JKT_A 510 LIAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPE-----V-KATIQDVLRSDSQLKNA-DVEL 576 (623) T ss_dssp TSSSSGGGCHHHHHHHHHHHHTT------SCHHHHHHHHHHHHHHHHHCTT-----T-HHHHHTTSSSHHHHTCS-SHHH T ss_pred HhcCCCCCChHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHHhCHH-----H-HHHHHHHHHhccccCCC-CHHH Confidence 4111 111111355566666655 3577889999999998864332 1 13455555555 444 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 577 r~~a~~~l~~~~~~ 590 (623) T 2JKT_A 577 QQRAVEYLRLSTVA 590 (623) T ss_dssp HHHHHHHHHHHHSS T ss_pred HHHHHHHHHHhccC Confidence 99999998877654 No 224 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=94.95 E-value=0.00036 Score=67.82 Aligned_cols=162 Identities=22% Similarity=0.254 Sum_probs=121.7 Template_Neff=12.000 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGAS 617 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~ 617 (747) +.+.++++.|+.++....++.++..++++|.+++...+. ....+.+ .++++.|+.++...+ ..++..++. T Consensus 166 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~ 240 (354) T 5IZ8_A 166 LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGG 240 (354) T ss_dssp HHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSCHH-----HHHHHHTSTTHHHHHHHHTTCCCTTSCCHHHHHHHH T ss_pred HHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChH-----hHHHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHH Confidence 356778888888887225677888999999999875232 2334455 688899998887533 678888999 Q NP_000290.2 618 LLSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 618 aLsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) +|.+++. .... ..+...++++.++.++.. .++.++..++.+|.+++...+.....+.+.++++.|+.++ T Consensus 241 ~L~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l 314 (354) T 5IZ8_A 241 ILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLI 314 (354) T ss_dssp HHHHHHHHHHTCHHHHHHHHTTTHHHHHHHTTTC------SCHHHHHHHHHHHHHHSSSCHHHHHHHHTTTHHHHHHHHS T ss_pred HHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhhc------CCHHHHHHHHHHHHHHHccCHHHHHHHHhCCHHHHHHHHH Confidence 9999873 2222 233455678888888876 3677899999999999985466666677778889999988 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .+. ++.++..++.+|.+++...+ T Consensus 315 ~~~-~~~v~~~a~~~L~~l~~~~~ 337 (354) T 5IZ8_A 315 HSK-HKMIAMGSAAALRNLMANRP 337 (354) T ss_dssp SCS-SHHHHHHHHHHHHHHHTTCC T ss_pred hcc-CHHHHHHHHHHHHHHHccCc Confidence 866 78899999999999997764 No 225 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=94.95 E-value=0.00036 Score=67.81 Aligned_cols=162 Identities=22% Similarity=0.254 Sum_probs=121.8 Template_Neff=12.000 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGAS 617 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~ 617 (747) +.+.++++.|+.++....++.++..++++|.+++...+. ....+.+ .++++.|+.++...+ ..++..++. T Consensus 166 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~ 240 (354) T 5IZA_A 166 LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGG 240 (354) T ss_dssp HHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHTSTTHHHHHHHHTCSSCSSCCHHHHHHHHH T ss_pred HHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChH-----hHHHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHH Confidence 356778888888887225677888999999999875232 2334455 688899998887533 678888999 Q NP_000290.2 618 LLSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 618 aLsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) +|.+++. .... ..+...++++.++.++.. .++.++..++.+|.+++...+.....+.+.++++.|+.++ T Consensus 241 ~L~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l 314 (354) T 5IZA_A 241 ILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLI 314 (354) T ss_dssp HHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTHHHHHHTTT T ss_pred HHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhhc------CCHHHHHHHHHHHHHHHccCHHHHHHHHhCCHHHHHHHHH Confidence 9999873 2222 233455678888888876 3677899999999999985466666677778889999988 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .+. ++.++..++.+|.+++...+ T Consensus 315 ~~~-~~~v~~~a~~~L~~l~~~~~ 337 (354) T 5IZA_A 315 HSK-HKMIAMGSAAALRNLMANRP 337 (354) T ss_dssp TCS-SHHHHHHHHHHHHHHHHTCC T ss_pred hcc-CHHHHHHHHHHHHHHHccCc Confidence 866 78899999999999997764 No 226 >5YVI_A Transportin-1, RNA-binding protein FUS; Importin family, PROTEIN TRANSPORT, PROTEIN; 2.9A {Homo sapiens} Probab=94.92 E-value=0.00036 Score=74.50 Aligned_cols=156 Identities=12% Similarity=0.081 Sum_probs=94.0 Template_Neff=13.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.+..++..++.++..++... T Consensus 645 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 717 (868) T 5YVI_A 645 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKP-CIADFMPILGTNLNPEFISVCNNATWAIGEISIQM 717 (868) T ss_dssp CHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCHH-----HHGG-GHHHHHHHHHHTCCTTSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhHH-----hHHH-HHHHHHHHHHhcCCcccHHHHHHHHHHHHHHHHHc Confidence 34555666665 35677888899999888764321 0111 11346666777777777888999999999888652 Q NP_000290.2 627 -LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 -e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .........+++.+...+.+. ..+..++..++.+|..++...+....... ..+++.++..+.+..++.++..++ T Consensus 718 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~r~~~~ 792 (868) T 5YVI_A 718 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 792 (868) T ss_dssp GGGGGGGGGGTHHHHHHHHTCT----TCCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTTSCSSHHHHHHH T ss_pred cccchhcHHHHHHHHHHHhcCC----CCChhHHHHHHHHHHHHHHHCHHHHHHHH-HHHHHHHHHHhhcCCChHHHHHHH Confidence 111111123566666666541 01467888899999988865332111111 234555555555322567888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 793 ~~l~~l~~~ 801 (868) T 5YVI_A 793 RGICTMISV 801 (868) T ss_dssp HHHHHC-CC T ss_pred HHHHHHHhh Confidence 888888754 No 227 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=94.91 E-value=0.00038 Score=73.02 Aligned_cols=108 Identities=17% Similarity=0.103 Sum_probs=69.7 Template_Neff=12.200 Q NP_000290.2 242 CSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL--RSPNQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 242 ~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL--~s~d~eVr~~AL~aLs~La~~~~ 319 (747) ....+++.+...+.+.++.++..++.++..+.... ....+++.+...+ .+.++.++..++.++..+..... T Consensus 108 ~~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~-------~~~~l~~~l~~~l~~~~~~~~vr~~a~~~L~~~~~~~~ 180 (621) T 6QH7_A 108 LIRLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------MAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSP 180 (621) T ss_dssp HHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHH-------HHHHHTTHHHHHHTTSCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHH-------HHHHHHhhHHHHHHcCCCCHHHHHHHHHHHHHHHHHCh Confidence 33445556666666677788888888888775421 1123455566666 66677888888888888765332 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ... .....++.+...+. +.++.++..++.++..+... T Consensus 181 ~~~---~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 217 (621) T 6QH7_A 181 DLV---PMGDWTSRVVHLLN-DQHLGVVTAATSLITTLAQK 217 (621) T ss_dssp GGC---CCCTTHHHHHHGGG-CSSHHHHHHHHHHHHHHHTT T ss_pred hhc---CccchHHHHHHHhc-CCCHHHHHHHHHHHHHHHHh Confidence 211 11245566667775 55677888888888887753 No 228 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=94.85 E-value=0.0004 Score=70.07 Aligned_cols=146 Identities=11% Similarity=0.055 Sum_probs=95.0 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.+..++..++.+|..+...... . . ....+++.+...+.+.+..++..++.++..+.... T Consensus 441 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~ 511 (588) T 1B3U_A 441 KLNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK------E-W-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVC 511 (588) T ss_dssp HHHHHHHHGGG-CSSHHHHHHHHHHHHHHHHHHCH------H-H-CCCCCHHHHHHTTTCSCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhc-CChHHHHHHHHHHHHHHHHHhCh------H-H-HHHhHHHHHHHhhcCCCHHHHHHHHHHHHHHHHHh Confidence 34566667776 46677888888888888764221 1 1 12356677777777777888888888888887642 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ......+++.+...+.+ .++.++..++.++..+...... ......+++.+...+.+. ++.++..+.. T Consensus 512 ~~-~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 580 (588) T 1B3U_A 512 GQ-DITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQE 580 (588) T ss_dssp HH-HHCCCCCHHHHHHGGGC------SCHHHHHHHHHHHHHHGGGSCH---HHCCCCCHHHHHHHTTCS-SHHHHHHHHH T ss_pred CH-HHHHhchHHHHHHHhCC------CcHHHHHHHHHHHHHHHHHhcC---CcchHHHHHHHHHHhcCC-ChhHHHHHHH Confidence 11 11123455666666665 3678899999999988754211 112224566677777765 7788888888 Q NP_000290.2 707 LLSDMW 712 (747) Q Consensus 707 aLsnL~ 712 (747) ++..+. T Consensus 581 ~l~~l~ 586 (588) T 1B3U_A 581 ALTVLS 586 (588) T ss_dssp HHHHTT T ss_pred HHHHhh Confidence 887765 No 229 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=94.77 E-value=0.00057 Score=75.04 Aligned_cols=161 Identities=14% Similarity=0.093 Sum_probs=111.6 Template_Neff=8.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-----SG----NSDV 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-----s~----d~eV 611 (747) +.+.++++.|+.+|.. . ....+..|+.+|.+|+...+. ....+.+.++++.|+.+|. ++ .... T Consensus 241 i~~~g~l~~Ll~lL~~-~~~~~~~k~~AaeiL~~L~~~~~~-----~r~~l~~~g~I~~LL~lL~~y~~~d~~~~~e~e~ 314 (568) T 4HM9_A 241 GAQQGLLQWLLKRLKA-KMPFDANKLYCSEVLAILLQDNDE-----NRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEM 314 (568) T ss_dssp HCCCCCHHHHHHHHHS-SCCCCHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHGGGTTSCCSSSHHHHH T ss_pred HHHCCHHHHHHHHHHc-CCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCchHHHHHHHHHhhhccCCCCHHHHHH Confidence 3567889999999983 3 466778899999999875332 2444456889999999995 11 1234 Q NP_000290.2 612 VRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS--QPQLAKQYFSSSMLNNI 688 (747) Q Consensus 612 r~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~--s~e~~~~Lve~giL~~L 688 (747) ...++.+|.+++..+.. ..++..++++.++.+|.. ....+..|+.+|..++.. .......+++.+++..| T Consensus 315 ~en~~~aL~~L~~~~~~r~~f~~~~gv~lLv~lL~~-------~~~~~~~Al~vL~~a~~~~~~~~~~~~~ve~ggl~~L 387 (568) T 4HM9_A 315 MENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE-------KKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTI 387 (568) T ss_dssp HHHHHHHHHHHTTSTHHHHHHHHTTHHHHHHHHHHH-------TSTTHHHHHHHHHHHHCSGGGHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHhCCHHHHHHHHHCChHHHHHHHHhC-------ChhHHHHHHHHHHHHhcCCCChhHHHHHHHHchHHHH Confidence 55668888888876544 355666788888888875 234567778888665442 34456677777888888 Q NP_000290.2 689 INLCRSS---------ASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 689 l~LL~s~---------~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.++... ......+.++.+|..|+.... T Consensus 388 ~~ll~~~~~~~~~~~~~~~e~~E~~~~iL~sL~~~~~ 424 (568) T 4HM9_A 388 FPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLR 424 (568) T ss_dssp HHHHHSCCCCCSSSSCCHHHHHHHHHHHHHHHHHHCC T ss_pred HHHHhcCcchhcCCCCCHHHHHHHHHHHHHHHHhcCC Confidence 8876532 134567888888888886543 No 230 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=94.76 E-value=0.00048 Score=72.19 Aligned_cols=144 Identities=13% Similarity=0.054 Sum_probs=85.0 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~~ 625 (747) .++.|+..+. +.++.++..++.++..+...... ....+++.+...+.+.+.. ++..++++++.+... T Consensus 442 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~~~ 510 (621) T 6QH5_A 442 YVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNL 510 (621) T ss_pred HHHHHHHHhc-CCCHHHcHHHHHHHHHHHhcCHH----------HHHHHHHHHHHHhhCCCCCHHHHHHHHHHHHHHHhh Confidence 4556666665 34556666777777766543111 1233455666666655544 777788888777654 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKAA 701 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eVr 701 (747) . .........+++.|...+.+ .+..++..++.+|..+....+. . ...+..++..+ .+. ++.++ T Consensus 511 ~~~~~~~~~~~~~~~L~~~l~~------~~~~vr~~a~~al~~l~~~~~~-----~-~~~l~~ll~~l~~~~~~-~~~vr 577 (621) T 6QH5_A 511 IAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPE-----V-KATIQDVLRSDSQLKNA-DVELQ 577 (621) T ss_pred CCCCCCCCHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCHH-----H-HhHHHHHHHHHHhcCCC-CHHHH Confidence 1 11110111245556666655 3567888899999988764322 1 12344555544 444 77889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.++..+.... T Consensus 578 ~~a~~~l~~~~~~~ 591 (621) T 6QH5_A 578 QRAVEYLRLSTVAS 591 (621) T ss_pred HHHHHHHHHhCCCc Confidence 99999988876543 No 231 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=94.68 E-value=0.00052 Score=58.87 Aligned_cols=134 Identities=25% Similarity=0.276 Sum_probs=89.8 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 126 (202) T 5MFO_F 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777777888899999999886544333334444577777777777777888889999998876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..+..++..++.++..++..... ...+.. ++++.|..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (202) T 5MFO_F 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGAEPALEQLQS 182 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHTTTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcChHHHHHHHHHCCHHHHHHHHHc Confidence 34456777777776 55677888888999888875322 222222 56666666664 No 232 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=94.66 E-value=0.00054 Score=58.80 Aligned_cols=134 Identities=25% Similarity=0.276 Sum_probs=89.7 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (202) T 5MFO_E 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777778888899999999886544333334444577777777777777888889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..+..++..++.++..++..... ...+.. ++++.|..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (202) T 5MFO_E 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGAEPALEQLQS 182 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCHHHHHHHHHHCCHHHHHHHHHc Confidence 33456777777776 55677888889999888875322 222222 56666666654 No 233 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=94.63 E-value=0.00067 Score=72.78 Aligned_cols=161 Identities=14% Similarity=0.093 Sum_probs=111.4 Template_Neff=8.700 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-----SG----NSDV 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-----s~----d~eV 611 (747) +.+.++++.|+.++.. . ....+..++.+|.+++...+. ....+.+.++++.|+.++. ++ .... T Consensus 163 i~~~~~l~~Ll~~L~~-~~~~~~~k~~a~~~L~~L~~~~~~-----~~~~l~~~g~i~~Ll~lL~~~~~~d~~~~~~~e~ 236 (490) T 4MFU_A 163 GAQQGLLQWLLKRLKA-KMPFDANKLYCSEVLAILLQDNDE-----NRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEM 236 (490) T ss_dssp HCCCCCHHHHHHHHHC-CSCCCHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHHTTSSSCCSSHHHHHH T ss_pred HHHCCHHHHHHHHHHc-CCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCchHHHHHHHHHhhhhcCCCCHHHHHH Confidence 3567889999999983 3 467788899999999875332 2444456789999999985 11 1234 Q NP_000290.2 612 VRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS--QPQLAKQYFSSSMLNNI 688 (747) Q Consensus 612 r~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~--s~e~~~~Lve~giL~~L 688 (747) ...++.+|++++..+.. ..++..++++.++.++.. ....+..|+.+|...+.. ++.....+++.+++..| T Consensus 237 ~en~~~aL~~L~~~~~~~~~f~~~~gi~llv~lL~~-------~~~~~~~AL~~L~~a~~~~~~~~~~~~~v~~ggl~~L 309 (490) T 4MFU_A 237 MENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE-------KKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTI 309 (490) T ss_dssp HHHHHHHHHHHHHSTHHHHHHHHTTHHHHHHHHHHT-------TSSTHHHHHHHHHHHHSSGGGHHHHHHHHHTTHHHHH T ss_pred HHHHHHHHHHHhCCHHHHHHHHHCCcHHHHHHHHhC-------ChhHHHHHHHHHHHHhcCCCCHHHHHHHHHHchHHHH Confidence 45568888888876444 355666788888888865 234566677777665442 34456677777888888 Q NP_000290.2 689 INLCRSS---------ASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 689 l~LL~s~---------~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.++... .+..+.+.++.+|..|+.... T Consensus 310 ~~~l~~~~~~~~~~~~~~~~~~E~~~~il~sL~~~~~ 346 (490) T 4MFU_A 310 FPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLR 346 (490) T ss_dssp HHHHHCCCCSCCSSCCCSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHhcCcccccCCCCCHHHHHHHHHHHHHHHHhcCC Confidence 8877542 134677888899888887543 No 234 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=94.58 E-value=0.00059 Score=68.47 Aligned_cols=145 Identities=11% Similarity=0.056 Sum_probs=94.9 Template_Neff=13.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..+...... . . ....+++.+...+.+.+..++..++.++..+..... T Consensus 436 ~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~ 506 (582) T 2NYL_A 436 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK------E-W-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 506 (582) T ss_dssp CHHHHHHGGG-CSSHHHHHHHHHHHHHHHHHHHH------H-H-HHHHTHHHHHHTTTCSSHHHHHHHHHHHHHHGGGSC T ss_pred HHHHHHHHhc-CCHHHHHHHHHHHHHHHHHHHCh------h-h-HHhcHHHHHHHhcCCCcHHHHHHHHHHHHHHHHHhC Confidence 4555666776 46777888899998888764221 1 1 124566777777777778888888998888876421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.++..+...... ......+++.+...+.+. ++.++..++.+ T Consensus 507 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 575 (582) T 2NYL_A 507 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 575 (582) T ss_dssp HH-HHHHHTHHHHHHTSSC------SSHHHHHHHHHHHTTSSTTSCH---HHCCCCCHHHTTTTTTCS-SHHHHHHHHTT T ss_pred HH-HHHhcHHHHHHHHhcC------ChHHHHHHHHHHHHHHHHHcCC---CCcHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 11 1123355666666665 3678889999999988764211 112224566677777665 77888888888 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) +..++ T Consensus 576 l~~l~ 580 (582) T 2NYL_A 576 LTVLS 580 (582) T ss_dssp TTTTT T ss_pred HHHhc Confidence 88765 No 235 >4U2X_F eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=94.35 E-value=0.00082 Score=57.14 Aligned_cols=73 Identities=21% Similarity=0.253 Sum_probs=49.2 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+...+.+.++.++..++.++.+++.. .+.....+...++++.+...+...++.++..++.++.+++... T Consensus 51 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 124 (175) T 4U2X_F 51 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 124 (175) T ss_dssp CHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHhCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHhcc Confidence 455555666666677888888999888753 2223333334466777777777666777888888888887643 No 236 >3SL9_B Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: GOL, EDO, PEG, IMD; 2.2A {Homo sapiens} Probab=94.35 E-value=0.00082 Score=56.48 Aligned_cols=110 Identities=24% Similarity=0.309 Sum_probs=73.4 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.. .+..++..++.++.+++.. +.....+...++++.+..++...++.++..++.++.+++......... T Consensus 56 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 134 (167) T 3SL9_B 56 MVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 134 (167) T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHHHHHHHCCcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHhHHHH Confidence 55566666665 5677888889999888743 333334444567788888887777788888999999888654332222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ....++++.+..++. ..++.++..++.++..+ T Consensus 135 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l 166 (167) T 3SL9_B 135 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQIL 166 (167) T ss_pred HHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHh Confidence 222456777777776 45566777777776654 No 237 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=94.34 E-value=0.0008 Score=67.65 Aligned_cols=110 Identities=11% Similarity=0.101 Sum_probs=57.6 Template_Neff=13.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL-E 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~-~ 324 (747) +++.+...+.+.++.++..++.++..+...... ......+++.+...+.+.++.++..++.++..+......... . T Consensus 239 ~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 315 (584) T 4I5L_D 239 VMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCREN 315 (584) T ss_dssp THHHHHHHHTCSSHHHHHHHHHTHHHHHHHHHH---HHCCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTSCTTTHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHHHHCC---CCChhhHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhcCccchhh Confidence 334444455555666777777777666543221 111123455566666666667777777777776643221110 0 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .....+++.+...+. +.++.++..++.++..+.. T Consensus 316 ~~~~~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~ 349 (584) T 4I5L_D 316 VIMSQILPCIKELVS-DANQHVKSALASVIMGLSP 349 (584) T ss_dssp HCCCCCHHHHHHHHT-CSCHHHHHHHHTTGGGGHH T ss_pred HHHHhHHHHHHHHcc-CCCHHHHHHHHHHHHHHHH Confidence 111234455555554 3445566666666665544 No 238 >4U2X_E eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=94.27 E-value=0.00091 Score=56.83 Aligned_cols=73 Identities=21% Similarity=0.253 Sum_probs=49.3 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+...+.+.++.++..++.++.+++.. .......+...+.++.+...+.+.++.++..++.++.+++... T Consensus 51 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 124 (175) T 4U2X_E 51 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 124 (175) T ss_dssp CHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHhcCHHHHHHHHHHHHHHcCCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHhhc Confidence 445555666666677888889999988753 2222333334456777777777667778888888888887654 No 239 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=94.24 E-value=0.00095 Score=70.34 Aligned_cols=106 Identities=12% Similarity=0.039 Sum_probs=70.7 Template_Neff=12.200 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+........ T Consensus 85 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~-------~~~~l~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~- 156 (657) T 4UQI_B 85 IMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMV- 156 (657) T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCch-------hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCHHHh- Confidence 445555666666677788888888888775421 112355666666777778888889988888875433221 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 157 --~~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 190 (657) T 4UQI_B 157 --EDQGFLDSLRDLIA-DSNPMVVANAVAALSEISES 190 (657) T ss_pred --cCcchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhc Confidence 12245666777776 55678888899988888764 No 240 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=94.04 E-value=0.0013 Score=79.08 Aligned_cols=155 Identities=11% Similarity=0.032 Sum_probs=110.7 Template_Neff=9.500 Q NP_000290.2 544 YHSDAIRTYLNLM---GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG----------------------LKEKGLP 598 (747) Q Consensus 544 ve~G~I~~LL~LL---~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll----------------------ie~giI~ 598 (747) +..++++.|..++ . +.++.++..|+.+|..++..... ....+ ...++++ T Consensus 506 ~~~~~l~~L~~ll~~~~-d~~~~vR~~a~~~l~~la~~~~~-----~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~ 579 (1454) T 5KC2_B 506 FVDYLLPRLKRLLISNR-QNTNYLRIVFANCLSDLAIIINR-----FQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQ 579 (1454) T ss_pred HHcCcHHHHHHHHcCCC-CCcHHHHHHHHHHHHHHhcCCCC-----cceEEhhHHhhhHHHHHHHHHHHHHHHHHcCHHH Confidence 4667888899988 7 47788899999999988754221 01111 1245667 Q NP_000290.2 599 QIARLLQS----GNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 599 ~Ll~LL~s----~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .|..++.. .++.++..|+.+|..+.......... .++++.|..++.+ .++.++..|+.+|..|+... T Consensus 580 ~l~~ll~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~-~~~l~~L~~~l~d------~~~~vR~~a~~al~~l~~~~-- 650 (1454) T 5KC2_B 580 SVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTN-DIILSHLITYLND------KDPALRVSLIQTISGISILL-- 650 (1454) T ss_pred HHHHHHHhhcCCCCHHHHHHHHHHHHHHhcCcCchhHH-hhhHHHHHHHccC------CCHHHHHHHHHHHHHHHHhh-- Confidence 77777765 78899999999999987652221111 4567888888876 47899999999999998743 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....+++.. ++.|+.+|.+. ++.++..++.+|..|+... T Consensus 651 ~~~~~~~~~-lp~L~~lL~d~-~~~vr~~al~aL~~L~~~~ 689 (1454) T 5KC2_B 651 GTVTLEQYI-LPLLIQTITDS-EELVVISVLQSLKSLFKTG 689 (1454) T ss_pred HHHHHHHcC-HHHHHHHhcCC-CHHHHHHHHHHHHHHhhCC Confidence 333444433 88888888876 7888999999999887655 No 241 >3SL9_E Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: PEG, GOL, IMD, EDO; 2.2A {Homo sapiens} Probab=94.03 E-value=0.0012 Score=55.43 Aligned_cols=110 Identities=24% Similarity=0.309 Sum_probs=72.2 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.. .+..++..++.++.+++.. ......+...++++.+..++...+..++..++.++.+++......... T Consensus 56 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 134 (167) T 3SL9_E 56 MVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 134 (167) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHCTTHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHHHHHHHCCcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHhHHHH Confidence 55566666665 5667888888898888743 333333444567777888887777788888999998887654332222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ....++++.+..++. ..++.++..++.++..+ T Consensus 135 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l 166 (167) T 3SL9_E 135 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQIL 166 (167) T ss_dssp HHHTTHHHHHHHHHH-HSCGGGHHHHHHHHHHH T ss_pred HHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHh Confidence 222456777777776 45566777777766654 No 242 >3VWA_B Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; HET: MSE; 2.2A {Saccharomyces cerevisiae} Probab=93.76 E-value=0.0017 Score=68.89 Aligned_cols=150 Identities=11% Similarity=0.077 Sum_probs=108.5 Template_Neff=10.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.++..+. +.++.++..++.+|..++..... . . ....+++.|..++.+.++.++..++.+|+.++.. T Consensus 379 ~~~l~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~ll~~l~~~l~d~~~~vR~~a~~~l~~i~~~ 449 (560) T 3VWA_B 379 SRIYPHFIQGLT-DSDATLRLQTLKTIPCIVSCLTE------R-Q-LNNELLRFLAKTQVDSDVEIRTWTVIIISKISTI 449 (560) T ss_dssp CCCHHHHHHGGG-CSCHHHHHHHHHHHHHHGGGSCH------H-C-CCCCHHHHHHHHTTCSSHHHHHHHHHHHHHHHTT T ss_pred hchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhCCH------H-H-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHH Confidence 457788888887 47788999999999998864221 1 1 2356788888888888899999999999999876 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .++.++..|+.+|..++.... ... +...+++.|..++.+. +..++..| T Consensus 450 ~~~~~~~~~~~l~~~l~~~l~d------~~~~vR~aa~~~l~~~~~~~~--~~~-~~~~~lp~l~~~l~d~-~~~VR~~a 519 (560) T 3VWA_B 450 LSTSVGNRSNILATAFTKSLKD------PQVKPRLAALYGLEKSIELFD--VNT-IANKILTVIAPGLLDK-SPIVRGRA 519 (560) T ss_dssp SSSCHHHHHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHTGGGSC--HHH-CCCCCHHHHGGGGGCS-SHHHHHHH T ss_pred hccccchhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHCC--HHH-HHHHHHHHHHHHHCCC-CHHHHHHH Confidence 211 111123455666677765 478899999999999886422 112 2245788888888877 88999999 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 520 ~~~l~~~~~~ 529 (560) T 3VWA_B 520 KILFEEYLEK 529 (560) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 9999888754 No 243 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=93.74 E-value=0.0018 Score=77.73 Aligned_cols=155 Identities=10% Similarity=0.029 Sum_probs=111.5 Template_Neff=9.900 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.|+.+|. +.++.+|..|+.+|..+...... .. .....++.|+.++.+.++.++..|+.+|..+... T Consensus 608 ~~~l~~Li~ll~-d~~~~VR~~a~~aL~~i~~~~~~-------~~-~~~~~i~~L~~~l~d~~~~vR~~a~~aL~~~~~~ 678 (1460) T 5DFZ_B 608 DIILSHLITYLN-DKDPALRVSLIQTISGISILLGT-------VT-LEQYILPLLIQTITDSEELVVISVLQSLKSLFKT 678 (1460) T ss_pred HhHHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhcCc-------hh-hchhHHHHHHHHhcCCCHHHHHHHHHHHHHhcCC Confidence 357888888888 57889999999999998864221 11 1234578888899988899999999999766543 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ......+..++++.|..++.+ .++.++..|+.+|..+....... .....+++.|+.++.+. ++.++..|+ T Consensus 679 ~~~~~~~~~~~i~~l~~~l~d------~~~~VR~~A~~al~~l~~~~~~~---~~~~~~l~~L~~~l~d~-~~~vr~~a~ 748 (1460) T 5DFZ_B 679 GLIRKKYYIDISKTTSPLLLH------PNNWIRQFTLMIIIEIINKLSKA---EVYCILYPIIRPFFEFD-VEFNFKSMI 748 (1460) T ss_pred cchhhcccchhHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCH---HHHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 222111112367778888876 47889999999999987642111 11234688888888877 889999999 Q NP_000290.2 706 LLLSDMWSSKELQG 719 (747) Q Consensus 706 ~aLsnL~~~~~~~~ 719 (747) .+|..+..+...+- T Consensus 749 ~aL~~~~~~~~~~~ 762 (1460) T 5DFZ_B 749 SCCKQPVSRSVYNL 762 (1460) T ss_pred HHhCCCCCHHHHHH Confidence 99999887776664 No 244 >6HWP_A A3_bGFPD; alphaRep, artificial protein, chimera, bidomain; 2.547A {synthetic construct} Probab=93.71 E-value=0.0016 Score=62.80 Aligned_cols=91 Identities=14% Similarity=0.155 Sum_probs=54.4 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.+..++..++..+..+.. ..+++.+...+.+.++.++..++..+..+.. T Consensus 23 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~-----------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~-------- 83 (409) T 6HWP_A 23 EKVEMYIKNLQDDSYYVRRAAAYALGKIGD-----------ERAVEPLIKALKDEDAWVRRAAADALGQIGD-------- 83 (409) T ss_dssp CCHHHHHHGGGCSSHHHHHHHHHHHHHSCC-----------GGGHHHHHHHTTCSSHHHHHHHHHHHHHHTC-------- T ss_pred HHHHHHHHHccCCCHHHHHHHHHHHHHhcC-----------HhhHHHHHHHhcCCCHHHHHHHHHHHHHhcC-------- Confidence 445556666666677778888877776643 1234445555556667777777777766543 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++.+...+. +.++.++..++.++..+. T Consensus 84 ---~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 113 (409) T 6HWP_A 84 ---ERAVEPLIKALK-DEDGWVRQSAAVALGQIG 113 (409) T ss_dssp ---GGGHHHHHHHTT-CSSHHHHHHHHHHHHHHT T ss_pred ---HhhHHHHHHHhc-CCCHHHHHHHHHHHHHHC Confidence 123344445554 445566666666666554 No 245 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=93.69 E-value=0.0017 Score=58.18 Aligned_cols=169 Identities=18% Similarity=0.246 Sum_probs=122.4 Template_Neff=12.300 Q NP_000290.2 542 WLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLS 620 (747) Q Consensus 542 ~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLs 620 (747) .+++.|+++.|+.++. ..++.++..++++|.+++...+. ....+.+.++++.|+.++. ..+..++..++++|. T Consensus 47 ~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~ 120 (233) T 3TT9_A 47 RVNQLRGILKLLQLLK-VQNEDVQRAVCGALRNLVFEDND-----NKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLW 120 (233) T ss_dssp HHHHTTHHHHHHHGGG-CCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHH T ss_pred HHHHcchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCc-----HHHHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHH Confidence 3467788999999998 46778889999999999874332 2444456789999999998 567889999999999 Q NP_000290.2 621 NMSRHPLL-HRVMGNQVFPEVTRLLTSHTGN---------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSM-LNNII 689 (747) Q Consensus 621 nLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~---------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~gi-L~~Ll 689 (747) +++..... ..+...+++..+..++...... ...+..++..++++|.+++...+.....+.+.+. ++.|+ T Consensus 121 ~l~~~~~~~~~~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 200 (233) T 3TT9_A 121 NLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLV 200 (233) T ss_dssp HHHTSGGGHHHHHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHHHHHHHTTSCHHHHHHHHTSTTHHHHHH T ss_pred HHccCHHHHHHhhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHHHHHHHHhcCHHHHHHHHHcccHHHHHH Confidence 99876433 3334455666666665431000 0014677889999999999855666666776666 88888 Q NP_000290.2 690 NLCRSSA-----SPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 690 ~LL~s~~-----d~eVr~aAL~aLsnL~~~~~ 716 (747) .++.... ++.++..++++|.+|+...+ T Consensus 201 ~~l~~~~~~~~~~~~~~~~~~~~L~~l~~~~~ 232 (233) T 3TT9_A 201 HYVRGTIADYQPDDKATENCVCILHNLSYQLE 232 (233) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHCCCCC T ss_pred HHHHcccccCCCChHHHHHHHHHHHHhhhccc Confidence 8887542 46788899999999887654 No 246 >3VWA_A Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; 2.2A {Saccharomyces cerevisiae} Probab=93.63 E-value=0.0019 Score=68.57 Aligned_cols=152 Identities=11% Similarity=0.067 Sum_probs=108.9 Template_Neff=10.600 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++..+. +.++.++..++.+|..++...+. . . ....+++.|..++.+.++.++..++.+|..++. T Consensus 378 ~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~ll~~l~~~l~d~~~~vR~~a~~~l~~i~~ 448 (560) T 3VWA_A 378 SSRIYPHFIQGLT-DSDATLRLQTLKTIPCIVSCLTE------R-Q-LNNELLRFLAKTQVDSDVEIRTWTVIIISKIST 448 (560) T ss_dssp CCCCHHHHHHGGG-CSSHHHHHHHHHHHHHHGGGCCH------H-C-CCCCCHHHHHHHTTCSSHHHHHHHHHHHHHHGG T ss_pred HhchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhCCH------H-H-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHH Confidence 3457888888887 47788999999999988864321 1 1 235678888888888889999999999999987 Q NP_000290.2 625 HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 625 ~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .... .......+++.+...+.+ .++.++..|+.+|..++.... ...+ ...+++.+..++.+. +..++.. T Consensus 449 ~~~~~~~~~~~~l~~~l~~~l~d------~~~~vR~~a~~~l~~~~~~~~--~~~~-~~~ilp~l~~ll~d~-~~~VR~~ 518 (560) T 3VWA_A 449 ILSTSVGNRSNILATAFTKSLKD------PQVKPRLAALYGLEKSIELFD--VNTI-ANKILTVIAPGLLDK-SPIVRGR 518 (560) T ss_dssp GSSSCHHHHHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHTGGGSC--HHHC-CCCCHHHHGGGGGCS-SHHHHHH T ss_pred HhccchhhhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHCC--HHHH-HHHHHHHHHHHHCCC-CHHHHHH Confidence 6211 111223455666677765 378899999999999886422 1122 235688888888877 8899999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) |+.+|..+...- T Consensus 519 a~~~l~~i~~~l 530 (560) T 3VWA_A 519 AKILFEEYLEKL 530 (560) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 999988877543 No 247 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=93.61 E-value=0.0019 Score=61.69 Aligned_cols=122 Identities=15% Similarity=0.146 Sum_probs=77.8 Template_Neff=11.300 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVD-LLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAV 335 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~-lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll 335 (747) .++.++..++..|..++.. ......+...++++.++. ++...++.++..++.++.+++.........+...++++.+. T Consensus 52 ~~~~~~~~al~~L~~l~~~-~~~~~~~~~~~~~~~l~~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~l~ 130 (296) T 1XQR_A 52 ADQQEREGALELLADLCEN-MDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLL 130 (296) T ss_dssp HHHHHHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHCCCCCTTCSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHH T ss_pred CCHHHHHHHHHHHHHHHcC-HHHHHHHHHcccHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCHHHHHH Confidence 4456777788888887764 333334445566777777 77776778888999999998865443333344445777777 Q NP_000290.2 336 SLLRRTG-NAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~-d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++. .. ++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 131 ~~l~-~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~ 177 (296) T 1XQR_A 131 RLLD-RDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQ 177 (296) T ss_dssp HHHH-HCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHh-cCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhh Confidence 7776 33 567788888888888764322 222222 45555555543 No 248 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=93.37 E-value=0.0023 Score=59.66 Aligned_cols=123 Identities=15% Similarity=0.159 Sum_probs=77.3 Template_Neff=11.900 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVD-LLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAV 335 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~-lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll 335 (747) .+..++..++..|..++.. ......+...++++.++. ++...+..++..++.++..++.........+...++++.+. T Consensus 36 ~~~~~~~~al~~L~~l~~~-~~~~~~~~~~~~i~~l~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 114 (280) T 1XQS_B 36 ADQQEREGALELLADLCEN-MDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLL 114 (280) T ss_dssp HHHHHHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHCCCCCTSCSCHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHH T ss_pred cCHHHHHHHHHHHHHHHhc-HHHHHHHHHcccHHHHHHHHhhcCCHHHHHHHHHHHHHHccCCHHHHHHHHHCCHHHHHH Confidence 4466777888888888654 233334445567777777 77766778888899999998865443333444445777777 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++....++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 115 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 161 (280) T 1XQS_B 115 RLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQ 161 (280) T ss_dssp HHHHSCSCHHHHHHHHHHHHHTTSSCHHHHHHHHTTTHHHHHHHHHT T ss_pred HHhccCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHhh Confidence 7775222566777888888888764322 222222 44555554443 No 249 >5VOZ_P V-type proton ATPase catalytic subunit; V-ATPase, SidK, rotational state 3;{Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=93.32 E-value=0.0027 Score=67.46 Aligned_cols=330 Identities=11% Similarity=0.063 Sum_probs=181.1 Template_Neff=8.900 Q NP_000290.2 290 CKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN---KLETR---RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 290 ~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~---~~~ll---~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) ..++.++.. .+.++...++.++..++...+ . ...++ ..+.++.++.++. . ++.++..++.+|..++... T Consensus 78 ~~li~LL~~~~~~d~~~~~l~~l~~ll~~~~-~~~~r~~~~~~~~~~~~~~li~lL~-~-d~~i~~~a~~~L~~L~~~~- 153 (478) T 5VOZ_P 78 IPLIHLLSTSDNEDCKKSVQNLIAELLSSDK-YGDDTVKFFQEDPKQLEQLFDVSLK-G-DFQTVLISGFNVVSLLVQN- 153 (478) T ss_dssp HHHHHHHHHCCCHHHHHHHHHHHHHHHHCSS-SCHHHHHHHHHCTHHHHHHTTSTTS-S-CHHHHHHHHHHHHHHHTSS- T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHcCCC-CccchhHHhccChhhHHHHHHHHcC-C-CHHHHHHHHHHHHHHHHhc- Confidence 556666654 466777788888888876544 3 22233 2456778888886 5 6677888888888887654 Q NP_000290.2 363 LK-EELIA-DALPV--LADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 363 ~~-~~Lve-giLe~--Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .. ..... ++++. ++.+|. ++ -++++-..|..||..-+. .+ T Consensus 154 ~~~~~~~~~~~l~~~~li~~L~---------~~------~~~~~~~~a~~~L~~L~~---------------------~~ 197 (478) T 5VOZ_P 154 GLHNVKLVEKLLKNNNLINILQ---------NI------EQMDTCYVCIRLLQELAV---------------------IP 197 (478) T ss_dssp SCCCHHHHHHHHSSHHHHHHHH---------CS------SCHHHHHHHHHHHHHHTT---------------------SH T ss_pred cccCcccchhhcccchHHHHHh---------cc------CCccHHHHHHHHHHHHcC---------------------Ch Confidence 32 11122 66776 777761 11 123444555555533211 11 Q NP_000290.2 439 AGRQTMRNY-SGLIDSLMAYVQNCVAA-----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYT 506 (747) Q Consensus 439 ~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 506 (747) ..|...... .|.|..|...+.+.... ...+..-..++...|.+|++ T Consensus 198 ~~r~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~---------------------- 255 (478) T 5VOZ_P 198 EYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTF---------------------- 255 (478) T ss_dssp HHHHHHHHSTTSSHHHHHHHHHHHHHSCSSCCCTTTSSSHHHHHHHHHHHHHHHHHTT---------------------- T ss_pred HHHHHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhc---------------------- Confidence 122222221 34455555444432110 00111111222222233322 Q NP_000290.2 507 EKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHS--DAIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMS 583 (747) Q Consensus 507 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~--G~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s 583 (747) +......+.+. ++++.|+.+++. .. +.++..++.+|.+++...+. T Consensus 256 -----------------------------~~~~~~~l~~~~~~~i~~Lv~ll~~-~~kekv~r~al~~L~nL~~~~~~-- 303 (478) T 5VOZ_P 256 -----------------------------NPVFANELVQKYLSDFLDLLKLVKI-TIKEKVSRLCISIILQCCSTRVK-- 303 (478) T ss_dssp -----------------------------SHHHHHHHHHHSHHHHGGGHHHHHH-CCCHHHHHHHHHHHHHHTSTTST-- T ss_pred -----------------------------CHHHHHHHHHHhHHHHHHHHHHHhc-cchHHHHHHHHHHHHHHhccChH-- Confidence 00111223444 789999999984 44 67888899999999875321 Q NP_000290.2 584 SG-MSQLIGLKEKGLPQIARLLQSG---NSDVVRSGASLLSNMSRH-------P------------------------LL 628 (747) Q Consensus 584 ~~-~~~~llie~giI~~Ll~LL~s~---d~eVr~~AL~aLsnLa~~-------~------------------------e~ 628 (747) .. .....+...+.+..++..|... +++++..+..++..+... + +. T Consensus 304 ~~~~~~~~l~~~~~~l~ll~~L~~~~~~d~~l~~~l~~l~~~L~~~~~~lss~dey~~el~sg~l~wsp~h~s~~f~~~n 383 (478) T 5VOZ_P 304 QHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDN 383 (478) T ss_dssp THHHHHHHCCCCCCHHHHHHHHTSCCCSCTHHHHHHHHHHHHHHHHHHTSCHHHHHHHHHHHTCCCCCTTTTCHHHHHHH T ss_pred hcHHHHHHHHHcCCHHHHHHHHHhCCCCcHHHHHHHHHHHHHHHHHHhhcCCHHHHHHHHHcCCCCCCCCcCCcChHHHh Confidence 00 0012333444344566666543 444544433333333100 0 01 Q NP_000290.2 629 -HRVM--GNQVFPEVTRLLTSHTGNT----SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 629 -~~ll--~~giI~~Ll~LL~s~s~~~----~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) ..+. ..++++.|+.+|....... ..+..++..++..|++++...+.....+.+.++++.|+.++.+. ++.++ T Consensus 384 ~~~~~~~~~~~l~~Lv~lL~~~~~~~~~~~~~~~~v~~~a~~~l~~lv~~~~~~~~~l~~~g~~~~L~~Ll~~~-~~~vr 462 (478) T 5VOZ_P 384 IDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHS-DSRVK 462 (478) T ss_dssp HHHHTTSSSHHHHHHHHHHHHHHHSSCSSSHHHHHHHHHHHHHHHHHHHHCTTTHHHHHHHTCHHHHHHHHTSS-CHHHH T ss_pred HHHhhhccHHHHHHHHHHHHhhhhCCCCCccccHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHhcCC-CHHHH Confidence 0111 2457788888886510000 01244577788899999665566666677778899999999877 88999 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..|+.++.+++.+ T Consensus 463 ~~Al~al~~l~~~ 475 (478) T 5VOZ_P 463 YEALKATQAIIGY 475 (478) T ss_dssp HHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhh Confidence 9999999988754 No 250 >5D80_H V-type proton ATPase catalytic subunit; Hydrolase, Autoinhibition; 6.202A {Saccharomyces cerevisiae} Probab=93.32 E-value=0.0027 Score=67.46 Aligned_cols=330 Identities=11% Similarity=0.063 Sum_probs=181.1 Template_Neff=8.900 Q NP_000290.2 290 CKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN---KLETR---RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 290 ~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~---~~~ll---~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) ..++.++.. .+.++...++.++..++...+ . ...++ ..+.++.++.++. . ++.++..++.+|..++... T Consensus 78 ~~li~LL~~~~~~d~~~~~l~~l~~ll~~~~-~~~~r~~~~~~~~~~~~~~li~lL~-~-d~~i~~~a~~~L~~L~~~~- 153 (478) T 5D80_H 78 IPLIHLLSTSDNEDCKKSVQNLIAELLSSDK-YGDDTVKFFQEDPKQLEQLFDVSLK-G-DFQTVLISGFNVVSLLVQN- 153 (478) T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHcCCC-CccchhHHhccChhhHHHHHHHHcC-C-CHHHHHHHHHHHHHHHHhc- Confidence 556666654 466777788888888876544 3 22233 2456778888886 5 6677888888888887654 Q NP_000290.2 363 LK-EELIA-DALPV--LADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 363 ~~-~~Lve-giLe~--Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .. ..... ++++. ++.+|. ++ -++++-..|..||..-+. .+ T Consensus 154 ~~~~~~~~~~~l~~~~li~~L~---------~~------~~~~~~~~a~~~L~~L~~---------------------~~ 197 (478) T 5D80_H 154 GLHNVKLVEKLLKNNNLINILQ---------NI------EQMDTCYVCIRLLQELAV---------------------IP 197 (478) T ss_pred cccCcccchhhcccchHHHHHh---------cc------CCccHHHHHHHHHHHHcC---------------------Ch Confidence 32 11122 66776 777761 11 123444555555533211 11 Q NP_000290.2 439 AGRQTMRNY-SGLIDSLMAYVQNCVAA-----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYT 506 (747) Q Consensus 439 ~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 506 (747) ..|...... .|.|..|...+.+.... ...+..-..++...|.+|++ T Consensus 198 ~~r~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~---------------------- 255 (478) T 5D80_H 198 EYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTF---------------------- 255 (478) T ss_pred HHHHHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhc---------------------- Confidence 122222221 34455555444432110 00111111222222233322 Q NP_000290.2 507 EKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHS--DAIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMS 583 (747) Q Consensus 507 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~--G~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s 583 (747) +......+.+. ++++.|+.+++. .. +.++..++.+|.+++...+. T Consensus 256 -----------------------------~~~~~~~l~~~~~~~i~~Lv~ll~~-~~kekv~r~al~~L~nL~~~~~~-- 303 (478) T 5D80_H 256 -----------------------------NPVFANELVQKYLSDFLDLLKLVKI-TIKEKVSRLCISIILQCCSTRVK-- 303 (478) T ss_pred -----------------------------CHHHHHHHHHHhHHHHHHHHHHHhc-cchHHHHHHHHHHHHHHhccChH-- Confidence 00111223444 789999999984 44 67888899999999875321 Q NP_000290.2 584 SG-MSQLIGLKEKGLPQIARLLQSG---NSDVVRSGASLLSNMSRH-------P------------------------LL 628 (747) Q Consensus 584 ~~-~~~~llie~giI~~Ll~LL~s~---d~eVr~~AL~aLsnLa~~-------~------------------------e~ 628 (747) .. .....+...+.+..++..|... +++++..+..++..+... + +. T Consensus 304 ~~~~~~~~l~~~~~~l~ll~~L~~~~~~d~~l~~~l~~l~~~L~~~~~~lss~dey~~el~sg~l~wsp~h~s~~f~~~n 383 (478) T 5D80_H 304 QHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDN 383 (478) T ss_pred hcHHHHHHHHHcCCHHHHHHHHHhCCCCcHHHHHHHHHHHHHHHHHHhhcCCHHHHHHHHHcCCCCCCCCcCCcChHHHh Confidence 00 0012333444344566666543 444544433333333100 0 01 Q NP_000290.2 629 -HRVM--GNQVFPEVTRLLTSHTGNT----SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 629 -~~ll--~~giI~~Ll~LL~s~s~~~----~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) ..+. ..++++.|+.+|....... ..+..++..++..|++++...+.....+.+.++++.|+.++.+. ++.++ T Consensus 384 ~~~~~~~~~~~l~~Lv~lL~~~~~~~~~~~~~~~~v~~~a~~~l~~lv~~~~~~~~~l~~~g~~~~L~~Ll~~~-~~~vr 462 (478) T 5D80_H 384 IDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHS-DSRVK 462 (478) T ss_pred HHHhhhccHHHHHHHHHHHHhhhhCCCCCccccHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHhcCC-CHHHH Confidence 0111 2457788888886510000 01244577788899999665566666677778899999999877 88999 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..|+.++.+++.+ T Consensus 463 ~~Al~al~~l~~~ 475 (478) T 5D80_H 463 YEALKATQAIIGY 475 (478) T ss_pred HHHHHHHHHHHhh Confidence 9999999988754 No 251 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=93.26 E-value=0.0024 Score=62.21 Aligned_cols=154 Identities=10% Similarity=0.056 Sum_probs=84.6 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM------------SSGMSQLIG---LKEKGLPQIARLLQSG------ 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~------------s~~~~~~ll---ie~giI~~Ll~LL~s~------ 607 (747) ++.++.++. +.++.++..++.++..++...... ......... .-..+++.+...+... T Consensus 261 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~~~~ 339 (442) T 1F59_B 261 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDD 339 (442) T ss_dssp HHHHHHHHH-SSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGTSCCSSCCCCHHHHHHHHHHHHHHHHTTCCCCCCCS T ss_pred HHHHHHHhc-CCcHHHHHHHHHHHHHHhhHHHHHHHHHHHHHhcCCCCchhhhHHHHHHHHHHHHHHHHHHccCCCCCCC Confidence 455666666 356677777888887776531000 000000000 0122344444444332 Q NP_000290.2 608 -NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSML 685 (747) Q Consensus 608 -d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL 685 (747) +..++..+..++..+...... .....+++.+...+.+ .++.++..++.++..+....+. ...... ..++ T Consensus 340 ~~~~~r~~a~~~l~~l~~~~~~--~~~~~~~~~l~~~l~~------~~~~~r~~al~~l~~l~~~~~~~~~~~~~-~~~~ 410 (442) T 1F59_B 340 DDWNPCKAAGVCLMLLATCCED--DIVPHVLPFIKEHIKN------PDWRYRDAAVMAFGCILEGPEPSQLKPLV-IQAM 410 (442) T ss_dssp SCCCHHHHHHHHHHHHHHHSTT--THHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHTSSSCHHHHHHHH-HTTH T ss_pred CCCcHHHHHHHHHHHHHHhccc--ccHHhHHHHHHHHhcC------CChHHHHHHHHHHHHHHhCCCHHHHHHHH-HHHH Confidence 345667777777777654111 1112244445555544 3677888999999988865332 111111 2456 Q NP_000290.2 686 NNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 686 ~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.+...+.+. ++.++..++++|..++. T Consensus 411 ~~l~~~l~d~-~~~vr~~a~~~l~~l~~ 437 (442) T 1F59_B 411 PTLIELMKDP-SVVVRDTAAWTVGRICE 437 (442) T ss_dssp HHHHHHTTCS-CSHHHHHHHHHHHHHHH T ss_pred HHHHHHhcCC-CHHHHHHHHHHHHHHHH Confidence 6677777665 78899999999988764 No 252 >6XTE_A Importin-5, antipain; human karyopherin, PA-PB1 sub-complex nuclear; HET: FC0, OAR; 2.27A {Homo sapiens} Probab=93.23 E-value=0.0025 Score=70.44 Aligned_cols=153 Identities=9% Similarity=0.114 Sum_probs=85.8 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 358 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 430 (1096) T 6XTE_A 358 IKEHIMQMLQ-NPDWKYRHAGLMALSAIGEGCHQ-----QMEG-ILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFA 430 (1096) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHTHHHHTT-----TTTT-THHHHHHHHHHGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhhHH-----HHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 3444555555 35677788888888887764221 0111 1134566677777777888999999999998865 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINL--------CRSSA 696 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~L--------L~s~~ 696 (747) .. .......+++.+...+.+. .+..++..++.+|..++...+. .....+ ..++..+... +.+. T Consensus 431 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~- 503 (1096) T 6XTE_A 431 PGFQKKFHEKVIAALLQTMEDQ-----GNQRVQAHAAAALINFTEDCPKSLLIPYL-DNLVKHLHSIMVLKLQELIQKG- 503 (1096) T ss_dssp THHHHHHHHHHHHHHHHHHHTC-----SCHHHHHHHHHHHHHHHHTSCHHHHGGGH-HHHHHHHHHHHHHHHHHHHHTC- T ss_pred HHHHHHHHHHHHHHHHHHhccc-----CCHHHHHHHHHHHHHHhccCCHHhHHHHH-HHHHHHHHHHHHHHHHHHHHcC- Confidence 11 1111233555566655541 2467788888888888764322 111111 1223333322 2222 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) +..++..++.++..++.. T Consensus 504 ~~~~~~~~~~~l~~l~~~ 521 (1096) T 6XTE_A 504 TKLVLEQVVTSIASVADT 521 (1096) T ss_dssp CCHHHHHHHHHHHHHHHH T ss_pred CHhHHHHHHHHHHHHHHH Confidence 456677777777766643 No 253 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=93.20 E-value=0.0025 Score=56.21 Aligned_cols=134 Identities=25% Similarity=0.298 Sum_probs=86.9 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++.......... T Consensus 87 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 166 (252) T 4HXT_A 87 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 166 (252) T ss_dssp HHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 44556666666677788888999988876543333333334567777777776677888889999988876543332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++. T Consensus 167 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 222 (252) T 4HXT_A 167 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLQKLLT 222 (252) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSBHHHHHHHHHTTHHHHHHHGGG T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 33456777777776 55677888889999888864322 222223 56666666654 No 254 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=93.19 E-value=0.0029 Score=75.01 Aligned_cols=153 Identities=10% Similarity=0.044 Sum_probs=93.2 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|...+. +.+..++..++.+|..++..... . .... ....++..|...+.+.++.++..++.+|..++.... T Consensus 932 l~~~L~~~L~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~ 1005 (1304) T 5IFE_C 932 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 1005 (1304) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhccC---c-CHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhC Confidence 4566666676 46678888999999988754221 0 0011 123456677777777777888888888888876521 Q NP_000290.2 628 L---HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~---~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ...+ ..+++.|..++.+ .+..++..++.+|..++...+.....-.-..++..++..+.+. +..++..+ T Consensus 1006 ~~~l~~~l-~~ll~~L~~~L~~------~~~~Vr~~ai~~L~~i~~~~~~~~~~~~~~~il~~Ll~~l~~~-~~~vr~~a 1077 (1304) T 5IFE_C 1006 MHKMTPPI-KDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRAT 1077 (1304) T ss_pred hHHhcccH-HhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHhcCcccCCHHHHHhhHHHHHHHccCC-CHHHHHHH Confidence 1 1112 2456666677665 3577888899999888764322111000012344455555544 66788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 1078 ~~~L~~l~~~ 1087 (1304) T 5IFE_C 1078 VNTFGYIAKA 1087 (1304) T ss_pred HHHHHHHHHH Confidence 8888877653 No 255 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=93.19 E-value=0.0029 Score=75.01 Aligned_cols=153 Identities=10% Similarity=0.044 Sum_probs=93.2 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|...+. +.+..++..++.+|..++..... . .... ....++..|...+.+.++.++..++.+|..++.... T Consensus 932 l~~~L~~~L~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~ 1005 (1304) T 6AHD_1 932 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 1005 (1304) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhccC---c-CHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhC Confidence 4566666676 46678888999999988754221 0 0011 123456677777777777888888888888876521 Q NP_000290.2 628 L---HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~---~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ...+ ..+++.|..++.+ .+..++..++.+|..++...+.....-.-..++..++..+.+. +..++..+ T Consensus 1006 ~~~l~~~l-~~ll~~L~~~L~~------~~~~Vr~~ai~~L~~i~~~~~~~~~~~~~~~il~~Ll~~l~~~-~~~vr~~a 1077 (1304) T 6AHD_1 1006 MHKMTPPI-KDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRAT 1077 (1304) T ss_pred hHHhcccH-HhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHhcCcccCCHHHHHhhHHHHHHHccCC-CHHHHHHH Confidence 1 1112 2456666677665 3577888899999888764322111000012344455555544 66788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 1078 ~~~L~~l~~~ 1087 (1304) T 6AHD_1 1078 VNTFGYIAKA 1087 (1304) T ss_pred HHHHHHHHHH Confidence 8888877653 No 256 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=93.12 E-value=0.0027 Score=64.56 Aligned_cols=146 Identities=10% Similarity=-0.008 Sum_probs=87.6 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++..+....++.++..++.+|..+..... . ....++.+...+.+.+..++..++.++..+..... T Consensus 428 ~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~~~-------~----~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 496 (592) T 6QH5_B 428 IIATLCENLDSLDEPDARAAMIWIVGEYAERID-------N----ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKP 496 (592) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhCC-------C----hhhHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 556666666522456777788888887765311 0 13456667777777778899999999998876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. +...+...+..++.+. .++.++..+..++..+.... ......+. ..++.++..+.+. ++.++..++.+ T Consensus 497 ~~--~~~~l~~~l~~~~~~~-----~~~~vr~~a~~~l~~l~~~~-~~~~~~~~-~~~~~l~~~~~~~-~~~~~~~~~~~ 566 (592) T 6QH5_B 497 SE--TQELVQQVLSLATQDS-----DNPDLRDRGYIYWRLLSTDP-VTAKEVVL-SEKPLISEETDLI-EPTLLDELICH 566 (592) T ss_pred HH--hhhhhHHHHHHHcCCC-----CCHHHHHHHHHHHHHHhcCc-hhhHHHHH-hhHHHHHHHcCCC-CHHHHHHHHHH Confidence 10 1111222222323331 25678888888888876542 21112221 2356666666555 67888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 567 l~~l~~~ 573 (592) T 6QH5_B 567 IGSLASV 573 (592) T ss_pred HHHHHHH Confidence 8877653 No 257 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=92.93 E-value=0.0031 Score=67.35 Aligned_cols=154 Identities=10% Similarity=0.023 Sum_probs=91.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... . .... ....+++.+...+.+.++.++..++.++..++.... T Consensus 480 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~ 553 (852) T 6EN4_C 480 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 553 (852) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhChh---h-cCHH-HHHhHHHHHHHHccCCCHHHHHHHHHHHHHHHHhhC Confidence 4556666666 46677888899999888764221 0 0001 123566777777777778888889999988876521 Q NP_000290.2 628 L--HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~--~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .......+++.+...+.+ .++.++..++.++..++...+...........+..++..+.+. +..++..++ T Consensus 554 ~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 626 (852) T 6EN4_C 554 MHKMTPPIKDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRATV 626 (852) T ss_pred chhchhhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCHHHCCHHHHHhcHHHHHHHhcCC-CHHHHHHHH Confidence 1 111112355666666655 3567888888888888764322111000012344455555444 566777777 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 627 ~~l~~l~~~ 635 (852) T 6EN4_C 627 NTFGYIAKA 635 (852) T ss_pred HHHHHHHHH Confidence 777777643 No 258 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=92.89 E-value=0.0032 Score=61.05 Aligned_cols=112 Identities=26% Similarity=0.312 Sum_probs=76.5 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+...++.++..++.+|.+++.........+...++++.+..++...+..++..++.++..++.........+ T Consensus 284 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 363 (397) T 6SA6_A 284 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 363 (397) T ss_dssp HHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCcHHHHHHHHHHHHHHhcCcHHHHHHHHhcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45556666666667788888888888876544333334445677788888877777888899999998886434333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 364 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 395 (397) T 6SA6_A 364 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 395 (397) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHH T ss_pred HHcCchHHHHHHHh-cccHHHHHHHHHHHHHHh Confidence 44456777777776 456677777887777665 No 259 >6FT5_A A3_A3; alphaRep, artificial protein, chimera, bidomain; HET: GOL, SO4; 1.94A {synthetic construct} Probab=92.89 E-value=0.0032 Score=60.70 Aligned_cols=91 Identities=14% Similarity=0.155 Sum_probs=53.6 Template_Neff=12.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.+..++..++..+..+.. ...++.+...+.+.++.++..++..+..+.. T Consensus 23 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~-----------~~~~~~l~~~l~~~~~~vr~~a~~~L~~~~~-------- 83 (409) T 6FT5_A 23 EKVEMYIKNLQDDSYYVRRAAAYALGKIGD-----------ERAVEPLIKALKDEDAWVRRAAADALGQIGD-------- 83 (409) T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHhcC-----------cchHHHHHHHhcCCCHHHHHHHHHHHHHHcC-------- Confidence 445556666666667777777777766643 1234445555556666777777777766543 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++.+...+. +.++.++..++.++..+. T Consensus 84 ---~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 113 (409) T 6FT5_A 84 ---ERAVEPLIKALK-DEDGWVRQSAAVALGQIG 113 (409) T ss_pred ---chhHHHHHHHhc-CCCHHHHHHHHHHHHhhC Confidence 123344455554 445566666666666554 No 260 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=92.86 E-value=0.0032 Score=54.65 Aligned_cols=146 Identities=11% Similarity=0.041 Sum_probs=96.0 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .. ....+++.+...+.+.++.++..++.++..+..... T Consensus 86 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~~~~~~~~~r~~a~~~l~~l~~~~~ 156 (232) T 3C5W_A 86 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK-------EW-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 156 (232) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHCH-------HH-CCCCCHHHHHHGGGCSSHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhCh-------hH-HHhcHHHHHHHHhCCCCHHHHHHHHHHHHHHHHHhC Confidence 4566666776 46677888899998888764221 11 123566777777777778888899999988876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.++..+....+. ......+++.+..++.+. ++.++..++.+ T Consensus 157 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~~~~~-~~~vr~~a~~~ 225 (232) T 3C5W_A 157 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 225 (232) T ss_dssp HH-HHHHHTHHHHHHGGGC------SSHHHHHHHHHHHHHHGGGSCH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHHH T ss_pred hh-ccHhcHHHHHHHHhCC------CcHHHHHHHHHHHHHHHHHcCc---hHHHHHHHHHHHHHHhcC-CHHHHHHHHHH Confidence 11 1122355666666665 3678888999999988764221 112234566777777765 77889989888 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..++. T Consensus 226 l~~l~~ 231 (232) T 3C5W_A 226 LTVLSL 231 (232) T ss_dssp HHHTTC T ss_pred HHHHhc Confidence 887753 No 261 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=92.86 E-value=0.0033 Score=56.30 Aligned_cols=110 Identities=11% Similarity=0.093 Sum_probs=66.6 Template_Neff=12.800 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..+.++.|+..+. +.++.++..++.+|..+...... . . ....+++.+...+.+.++.++..++.+|..+.. T Consensus 31 ~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~ 101 (258) T 4LAC_A 31 SLYPIAVLIDELR-NEDVQLRLNSIKKLSTIALALGV------E-R-TRSELLPFIVELAEDAKWRVRLAIIEYMPLLAG 101 (258) T ss_pred cccHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHccCH------H-H-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHH Confidence 3456777788887 46778888888888888754221 1 1 123456667777777777888888888887765 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .... ......+++.+..++.+ .++.++..++.+|..++. T Consensus 102 ~~~~-~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 140 (258) T 4LAC_A 102 QLGV-EYFDEKLNSLCMAWLVD------HVYAIREAATSNLKKLVE 140 (258) T ss_pred hCCC-hHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 4111 00112234444455444 245666666666666654 No 262 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=92.57 E-value=0.0039 Score=65.83 Aligned_cols=150 Identities=10% Similarity=0.046 Sum_probs=86.4 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.++.++..++.++..++.. . T Consensus 360 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~v~~~~~~~l~~~~~~~~ 432 (852) T 4FDD_A 360 ILPLLKELLF-HHEWVVKESGILVLGAIAEGCMQ-----GMIP-YLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVV 432 (852) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHTTTTTHH-----HHGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHTHHHHH T ss_pred HHHHHHHHHh-CCChHHHHHHHHHHHHHHHHHHH-----hhHH-hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhc Confidence 3444555555 35667777888888888764321 1111 1234666777777777788889999999888764 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ .++.++..++.++..++........... ..++..+...+.+. +..++..++ T Consensus 433 ~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~ 504 (852) T 4FDD_A 433 SQPPDTYLKPLMTELLKRILD------SNKRVQEAACSAFATLEEEACTELVPYL-AYILDTLVFAFSKY-QHKNLLILY 504 (852) T ss_dssp HSCTTTTHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHGGGGGGGH-HHHHHHHHHHHHHC-CHHHHHHHH T ss_pred CCCCCcchHHHHHHHHHHHHc------CCHHHHHHHHHHHHHHHHHHHHhhHHHH-HHHHHHHHHHhhcc-CHHHHHHHH Confidence 11 011112344555555554 2567888888888888764322111111 23455555555544 445566666 Q NP_000290.2 706 LLLSDMW 712 (747) Q Consensus 706 ~aLsnL~ 712 (747) .+|..++ T Consensus 505 ~~l~~l~ 511 (852) T 4FDD_A 505 DAIGTLA 511 (852) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 6666665 No 263 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=92.57 E-value=0.004 Score=54.44 Aligned_cols=148 Identities=8% Similarity=0.066 Sum_probs=97.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.+..++..++.++..++.... T Consensus 53 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 125 (230) T 5NR4_A 53 TVDALTGWVG-SSNYRVSLMGLEILSAFVDRLST-----RFKS-YVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVA 125 (230) T ss_dssp HHHHHHHHHH-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhhH-----HHHH-HHHHHHHHHHHHhccCCHHHHHHHHHHHHHHHHcCC Confidence 5566667776 46778888999999988764321 1111 123567777777777777888889999888875421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ...+++.+...+.+ .++.++..++.++..++........ ....+++.+...+.+. ++.++..++.+ T Consensus 126 ~----~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 192 (230) T 5NR4_A 126 P----PMYIWEQLASGFKH------KNFRSREGVCLCLIETLNIFGAQPL--VISKLIPHLCILFGDS-NSQVRDAAILA 192 (230) T ss_dssp C----HHHHHHHHGGGGGC------SCHHHHHHHHHHHHHHHHHHCSTTS--CHHHHHHHHHHHTTCS-SHHHHHHHHHH T ss_pred C----HHHHHHHHHhcCCC------CCHHHHHHHHHHHHHHHHHhCCCcc--cHHHHHHHHHHHHCCC-CHHHHHHHHHH Confidence 1 11244555555554 3677888889998888764322211 1124567777777766 78899999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) +..+.... T Consensus 193 l~~l~~~~ 200 (230) T 5NR4_A 193 IVEIYRHV 200 (230) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 98887543 No 264 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=92.51 E-value=0.0041 Score=53.94 Aligned_cols=107 Identities=12% Similarity=0.133 Sum_probs=62.9 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.++.++..++..|..+...... . . ....+++.+...+.+.++.++..++.++..++.... T Consensus 8 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~ 78 (232) T 3C5W_A 8 PIAVLIDELR-NEDVQLRLNSIKKLSTIALALGV------E-R-LSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLG 78 (232) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHTTHHHHHHHHCS------S-H-CCCCCHHHHHHHTTCSSHHHHHHHHTTHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCh------H-H-HHHhHHHHHHHHHhCCCHHHHHHHHHHHHHHHHhhC Confidence 4566777776 46677888888888887754221 1 1 123556667777777777788888888887765411 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. .....+++.+...+.+ .++.++..++.++..++. T Consensus 79 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~ 114 (232) T 3C5W_A 79 VE-FFDEKLNSLCMAWLVD------HVYAIREAATSNLKKLVE 114 (232) T ss_dssp GG-GTTTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHH T ss_pred HH-HHHHHHHHHHHHHHhC------CCHHHHHHHHHHHHHHHH Confidence 10 1111234444444444 245566666666666554 No 265 >6XU2_A Importin-5, antipain; human karyopherin, PA-PB1 sub-complex nuclear; HET: FC0, OAR; 2.834A {Homo sapiens} Probab=92.50 E-value=0.0042 Score=68.79 Aligned_cols=152 Identities=9% Similarity=0.112 Sum_probs=85.0 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 377 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 449 (1115) T 6XU2_A 377 IKEHIMQMLQ-NPDWKYRHAGLMALSAIGEGCHQ-----QMEG-ILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFA 449 (1115) T ss_dssp HHHHHHHHHS-SSCSHHHHHHHHHHHHHHHHHHH-----HHTT-THHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhhHH-----HHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 3444555555 35677788888888887764221 0111 1134566677777777888999999999988865 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINL--------CRSSA 696 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~L--------L~s~~ 696 (747) .. .......+++.+...+.+. .+..++..++.+|..++...+. .....+ ..++..+... +.+. T Consensus 450 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~- 522 (1115) T 6XU2_A 450 PGFQKKFHEKVIAALLQTMEDQ-----GNQRVQAHAAAALINFTEDCPKSLLIPYL-DNLVKHLHSIMVLKLQELIQKG- 522 (1115) T ss_dssp THHHHHHHHHHHHHHHHHHHTT-----CCHHHHHHHHHHHHHHHHTSCHHHHGGGH-HHHHHHHHHHHHHHHHHHHHTC- T ss_pred HHHHHHHHHHHHHHHHHHhccc-----CCHHHHHHHHHHHHHHhccCCHHhHHHHH-HHHHHHHHHHHHHHHHHHHHcC- Confidence 11 1111223555566555431 2567788888888888764322 111111 1223333322 2222 Q NP_000290.2 697 SPKAAEAARLLLSDMWS 713 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~ 713 (747) +..++..++.++..++. T Consensus 523 ~~~~~~~~~~~l~~l~~ 539 (1115) T 6XU2_A 523 TKLVLEQVVTSIASVAD 539 (1115) T ss_dssp CCHHHHHHHHHHHHHHH T ss_pred CHhHHHHHHHHHHHHHH Confidence 45566667777766654 No 266 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=92.46 E-value=0.0043 Score=55.46 Aligned_cols=146 Identities=11% Similarity=0.041 Sum_probs=96.3 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..++..... .. ....+++.+...+.+.+..++..++.++..+..... T Consensus 112 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 182 (258) T 4LAC_A 112 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK-------EW-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 182 (258) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCh-------hH-HHHhHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcCC Confidence 4566666776 46678888899999888764221 11 234567777777777778889999999888876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.+|..+...... ......+++.+..++.+. ++.++..++.+ T Consensus 183 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 251 (258) T 4LAC_A 183 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 251 (258) T ss_pred CC-ccHhhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCc---chhHHHHHHHHHHHHCCC-CHHHHHHHHHH Confidence 11 1122355666666665 3678888999999888754221 112234566677777765 77888899888 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 252 l~~l~~ 257 (258) T 4LAC_A 252 LTVLSL 257 (258) T ss_pred HHHHHh Confidence 887753 No 267 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=92.45 E-value=0.0043 Score=66.18 Aligned_cols=147 Identities=10% Similarity=0.006 Sum_probs=89.0 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.++..+. +.+..++..++.++..+....+. ....+ -..+++.+...+.+.+..++..++.++..+.... T Consensus 675 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~ 747 (852) T 6EN4_C 675 TVLPALMNEYR-VPELNVQNGVLKSLSFLFEYIGE-----MGKDY-IYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGV 747 (852) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHhhCch-----hhHHH-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHcC Confidence 35666777776 46677888899999888764321 01111 1356667777777777778888877777776541 Q NP_000290.2 627 -LLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 -e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... ......+++.+...+.+ .++.++..++.++..+...... ...++.+...+.+. ++.++..+ T Consensus 748 ~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~-------~~~~~~l~~~l~~~-~~~vr~~a 813 (852) T 6EN4_C 748 YGFGCEDSLNHLLNYVWPNVFE------TSPHVIQAVMGALEGLRVAIGP-------CRMLQYCLQGLFHP-ARKVRDVY 813 (852) T ss_pred ccCCcHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhhCc-------cchHHHHHHHhCCC-cHHHHHHH Confidence 110 00111233333333333 2567777888888777643211 23455566666655 77889999 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..+... T Consensus 814 ~~~l~~l~~~ 823 (852) T 6EN4_C 814 WKIYNSIYIG 823 (852) T ss_pred HHHHHHHHhh Confidence 9998888754 No 268 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=92.44 E-value=0.0043 Score=66.06 Aligned_cols=151 Identities=10% Similarity=0.047 Sum_probs=89.7 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.++.++..++.++..++... T Consensus 398 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 470 (890) T 1QBK_B 398 ILPLLKELLF-HHEWVVKESGILVLGAIAEGCMQ-----GMIP-YLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVV 470 (890) T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhHh-----hhHh-hHHHHHHHHHHHhcCCChHHHHHHHHHHHHHHHHHc Confidence 3445555555 35677888888888888764321 1111 12346677777777778889999999999887651 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ .++.++..++.++..++........... ..+++.+...+.+. +..++..++ T Consensus 471 ~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~ 542 (890) T 1QBK_B 471 SQPPDTYLKPLMTELLKRILD------SNKRVQEAACSAFATLEEEACTELVPYL-AYILDTLVFAFSKY-QHKNLLILY 542 (890) T ss_pred CCCCchhhHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHHHHhhHHHH-HHHHHHHHHHhhcc-CHHHHHHHH Confidence 11 111112345555555554 3567888889998888764322111111 23455555555544 455666666 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..++. T Consensus 543 ~~l~~l~~ 550 (890) T 1QBK_B 543 DAIGTLAD 550 (890) T ss_pred HHHHHHHH Confidence 77666654 No 269 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=92.43 E-value=0.0043 Score=62.06 Aligned_cols=145 Identities=10% Similarity=0.022 Sum_probs=87.2 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+....++.++..++.+|..+..... . ....++.+...+.+.++.++..++.+|..+..... T Consensus 415 ~~~~l~~~l~~~~~~~~r~~a~~~l~~~~~~~~-------~----~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 483 (570) T 6CRI_I 415 VIATLCENLDSLDEPEARAAMIWIVGEYAERID-------N----ADELLESFLEGFHDKSTQVQLQLLTAIVKLFLKKP 483 (570) T ss_dssp THHHHTSSCTTCCCHHHHHHHHHHHHHTTTTST-------T----HHHHHHHHTTSGGGSCSHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHchhhCCCHHHHHHHHHHHHHHHHhcc-------C----HHHHHHHHHHccCCCCHHHHHHHHHHHHHHHhcCc Confidence 456666666522456777788888887765311 0 13456667777777778889999999988876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRL-LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~L-L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . . +.. .+..++.. +.+. .+..++..+..++..+.... ......+ ...++.++..+.+. ++.++..++. T Consensus 484 ~-~-~~~-~~~~~l~~~~~~~-----~~~~vr~~a~~~~~~l~~~~-~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~~ 552 (570) T 6CRI_I 484 T-E-TQE-LVQQVLSLATQDS-----DNPDLRDRGYIYWRLLSTDP-VAAKEVV-LAEKPLISEETDLI-EPTLLDELIC 552 (570) T ss_dssp T-T-THH-HHHHHHCCCCCSC-----CCHHHHHHHHHHHHHHHHCH-HHHHHHT-SCCCCCCCCCCCCC-CHHHHHHHHS T ss_pred H-H-HHH-HHHHHHHHHhcCC-----CCchHHHHHHHHHHHhcCCh-HHHHHHH-HccCCCCCccccCC-chhHHHHHHH Confidence 1 0 111 12222222 3321 15678888888888776542 2111222 23466666666655 6788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 553 ~l~~l~~~ 560 (570) T 6CRI_I 553 YIGTLASV 560 (570) T ss_dssp CSSBHHHH T ss_pred HhhcHHHH Confidence 88887754 No 270 >2RU4_B Armadillo Repeat Protein, N-terminal fragment; solenoid repeat, Armadillo repeat motif; NMR {synthetic construct} Probab=92.41 E-value=0.0045 Score=45.28 Aligned_cols=71 Identities=30% Similarity=0.361 Sum_probs=42.5 Template_Neff=12.400 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ++++.+...+...+..++..+++++.+++.........+...+.+..+...+. ..++.++..++.++.+++ T Consensus 12 ~~~~~l~~~l~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~ 82 (84) T 2RU4_B 12 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 82 (84) T ss_dssp TSHHHHHHHTTCSCHHHHHHHHHHHHHHHTCSSSTTHHHHHHTCHHHHHHHTT-SSCHHHHHHHHHHHHHHC T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHh Confidence 45555666666556677788888888877653332223333445555665554 345566666777766654 No 271 >4L7M_A Putative uncharacterized protein; HEAT-repeats, Hypothetical, UNKNOWN FUNCTION; HET: MSE, GOL; 2.002A {Thermococcus onnurineus} Probab=92.32 E-value=0.0047 Score=55.57 Aligned_cols=75 Identities=17% Similarity=0.187 Sum_probs=52.1 Template_Neff=12.800 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) +.+.++.+...+. +.++.++..++.+|..+...... . .... .....++.|...+.+.++.++..++.+|..+.. T Consensus 35 ~~~~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~ 108 (269) T 4L7M_A 35 DKRALFLILELAG-EDDETTRLRAFVALGEILKRADS---D-LRMM-VLERHLDVFINALSQENEKVTIKALRALGYLVK 108 (269) T ss_dssp CHHHHHHHHHHTT-SSCHHHHHHHHHHHHHHHTTSCH---H-HHHH-HHHHHHHHHHHTCCSSSHHHHHHHHHHHHHHHT T ss_pred CcchHHHHHHHhC-CCCHHHHHHHHHHHHHHHhcCCH---H-HHHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 4467778888887 46778888999999888764211 0 0111 123567777888887788888889998888876 Q NP_000290.2 625 H 625 (747) Q Consensus 625 ~ 625 (747) . T Consensus 109 ~ 109 (269) T 4L7M_A 109 D 109 (269) T ss_dssp T T ss_pred c Confidence 3 No 272 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=92.23 E-value=0.0059 Score=72.68 Aligned_cols=100 Identities=11% Similarity=0.096 Sum_probs=68.1 Template_Neff=8.700 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLH----------- 629 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~----------- 629 (747) ++.++..++.+|..|+...+. ........++++.|+.+|.+.+++++..++.+|++++...... T Consensus 612 ~~~lr~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~L~~lL~~~~~~VRaaal~aL~~li~~~~~~~~~~~~~~~~~ 686 (1287) T 5WBJ_A 612 EPLFLQWLCLCLGKLWEDFME-----AQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDIGFDSNKSVVEDEFDD 686 (1287) T ss_dssp CHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHGGGGGCSCHHHHHHHHHHHHHTCC------------CCCC T ss_pred CHHHHHHHHHHHHHHHhccHH-----HHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCccccccccCCCCCH Confidence 456667788888888765432 1233345678889999999889999999999999998762110 Q NP_000290.2 630 ---RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 630 ---~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..+..+++..|..++.+ .++.++..++.+|++++.. T Consensus 687 ~~~~~~~~~i~~~l~~~~~D------~S~~VR~e~~~aLs~~~~~ 725 (1287) T 5WBJ_A 687 DEKIRAEDAIIKSLLDVVSD------GSPLVRAEVAVALARFAFG 725 (1287) T ss_dssp CHHHHHHHHHHHHHHTTTTC------SCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHh Confidence 00233455566666655 3678889999999888754 No 273 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=92.22 E-value=0.0059 Score=72.65 Aligned_cols=101 Identities=11% Similarity=0.093 Sum_probs=68.3 Template_Neff=8.700 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLH---------- 629 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~---------- 629 (747) .++.++..++.+|..|+...+. ........++++.|+.+|.+.+++++..++.+|+.++...... T Consensus 611 ~~~~lr~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~L~~lL~~~~~~VRaaal~AL~~li~~~~~~~~~~~~~~~~ 685 (1287) T 5WBK_A 611 PEPLFLQWLCLCLGKLWEDFME-----AQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDIGFDSNKSVVEDEFD 685 (1287) T ss_dssp -CHHHHHHHHHHHHHHHTTCHH-----HHHHHHTTTHHHHHGGGGGCSCHHHHHHHHHHHHHHCC------------CCC T ss_pred CCHHHHHHHHHHHHHHHcccHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCccccccccCCCCC Confidence 3456677788888888765432 1233345678889999999888999999999999998762110 Q NP_000290.2 630 ----RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 630 ----~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..+..+++..|..++.+ .++.++..++.+|++++.. T Consensus 686 ~~~~~~~~~~i~~~l~~~~~D------~s~~VR~e~~~als~~~~~ 725 (1287) T 5WBK_A 686 DDEKIRAEDAIIKSLLDVVSD------GSPLVRAEVAVALARFAFG 725 (1287) T ss_dssp CCHHHHHHHHHHHHHHTTTTC------SCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHh Confidence 01233455566666655 3678888899999888754 No 274 >2QK2_A LP04448p; Mini spindles, Msps, XMAP215, Dis1; 2.1A {Drosophila melanogaster} Probab=92.22 E-value=0.005 Score=54.55 Aligned_cols=145 Identities=9% Similarity=0.135 Sum_probs=94.6 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+. +.++.++..++..|..+....+. .... .-..+++.+...+ .+.++.++..++.+|..+... T Consensus 16 l~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~ 88 (242) T 2QK2_A 16 MPKDFYDKLE-EKKWTLRKESLEVLEKLLTDHPK-----LENG-EYGALVSALKKVITKDSNVVLVAMAGKCLALLAKGL 88 (242) T ss_dssp SCTTHHHHHT-CSSHHHHHHHHHHHHHHHHHCSS-----BCCC-CCHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHH T ss_pred CCHHHHHHHh-ccchHHHHHHHHHHHHHHhhCcc-----cccc-hHHHHHHHHHHHHccCcHHHHHHHHHHHHHHHHHHh Confidence 4566777777 47788888999999988764321 1111 1134667777777 777788999999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .... ..+++.+...+.+ .+..++..++.+|..+....+ ....++.+...+.+. ++.++..+ T Consensus 89 ~~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~-------~~~~~~~l~~~l~~~-~~~~r~~~ 153 (242) T 2QK2_A 89 AKRFSNYA-SACVPSLLEKFKE------KKPNVVTALREAIDAIYASTS-------LEAQQESIVESLSNK-NPSVKSET 153 (242) T ss_dssp GGGGHHHH-HHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTSC-------HHHHHHHHHHHTTCS-CHHHHHHH T ss_pred hHhHHHHH-HhHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHcCC-------HHHHHHHHHHHHcCC-CHHHHHHH Confidence 211 1111 2356666666665 356788888888888875421 112455566666655 67778888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 154 ~~~l~~l~~~ 163 (242) T 2QK2_A 154 ALFIARALTR 163 (242) T ss_dssp HHHHHHHHTT T ss_pred HHHHHHHHHh Confidence 8887777653 No 275 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=92.21 E-value=0.005 Score=67.54 Aligned_cols=115 Identities=14% Similarity=0.059 Sum_probs=64.9 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+...............+++.+...+. +.+..++..++.++..++........ T Consensus 397 ~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~~~ 476 (1078) T 3W3U_A 397 KILDMVIPLINDPHPRVQYGCCKVLGQISTAFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVAFSEFASKDIL 476 (1078) T ss_dssp HHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHSSTTSCHHHHHHHHHHHHHHHTTCCHHHH T ss_pred HHHHHHHHHccCCCHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHhCChhhh Confidence 34444455555566778888888888876543221111111234555555555 34566777788888777654322111 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......++..+...+. ..++.++..++.++..++.. T Consensus 477 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 512 (1078) T 3W3U_A 477 EPYLDSLLTNLLVLLQ-SNKLYVQEQALTTIAFIAEA 512 (1078) T ss_dssp GGGHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1111245555666665 44567778888888877754 No 276 >2IW3_B ELONGATION FACTOR 3A; ACETYLATION, ATP-BINDING, ELONGATION FACTOR, PROTEIN; HET: MSE, ADP, SO4; 2.4A {SACCHAROMYCES CEREVISIAE} Probab=92.03 E-value=0.0058 Score=68.10 Aligned_cols=148 Identities=16% Similarity=0.128 Sum_probs=74.2 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|..++. +.+..++..|+.+|..++..... .. ....++.++..+.+.+. ...++..+..+..... T Consensus 176 i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-------~~--~~~~~~~l~~~l~~~~~--~~~~~~~l~~~~~~~~ 243 (986) T 2IW3_B 176 LIPVLSETMW-DTKKEVKAAATAAMTKATETVDN-------KD--IERFIPSLIQCIADPTE--VPETVHLLGATTFVAE 243 (986) T ss_dssp HHHHHHHHTT-CSCHHHHHHHHHHHHHHGGGCCS-------ST--TGGGHHHHHHHHHCGGG--HHHHHHHHTTCCCCSC T ss_pred HHHHHHHhcC-cCCHHHHHHHHHHHHHHHHhcCc-------HH--HHHHHHHHHHHhcCccc--chHHHHHHHHchhhcc Confidence 5566667776 45667777888888777653211 11 12344455555543322 2222323222222110 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ........+++.+...+.+ .++.++..++.++..++........ ......+++.|+.++.+..++.++..++. T Consensus 244 ~~~~~~~~~l~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~i~~~l~~~l~d~~d~~vr~~a~~ 317 (986) T 2IW3_B 244 VTPATLSIMVPLLSRGLNE------RETGIKRKSAVIIDNMCKLVEDPQVIAPFLGKLLPGLKSNFATIADPEAREVTLR 317 (986) T ss_dssp CCHHHHHHHHHHHHHHHTS------SSHHHHHHHHHHHHHHHTTCCCHHHHHHHHTTTHHHHHHHHHHCCCHHHHHHHHH T ss_pred cCHHHHHhHHHHHHHhccc------ccccccHHHHHHHHHHHHHhcCHhHHHHHHHHHHHHHHHhhcCCCCHHHHHHHHH Confidence 0000011245555555554 3567778888888877754211100 00112356666666665423677777777 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) +|..+.. T Consensus 318 ~l~~l~~ 324 (986) T 2IW3_B 318 ALKTLRR 324 (986) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 7777643 No 277 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=91.94 E-value=0.0059 Score=54.01 Aligned_cols=150 Identities=10% Similarity=0.094 Sum_probs=93.1 Template_Neff=12.600 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+. +.++.++..++..|..++..... . .... ....+++.+...+.+.++.++..++.++..++... T Consensus 7 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~v~~~a~~~l~~l~~~~ 80 (237) T 4G3A_B 7 SDLDGFIQQMP-KADMRVKVQLAEDLVTFLSDDTN---S-IVCT-DMGFLIDGLMPWLTGSHFKIAQKSLEAFSELIKRL 80 (237) T ss_dssp SSHHHHHHHST-TCCHHHHHHHHHHHHHHHHCTTS---C-CCCS-CHHHHHHHHGGGGSSSCHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHhcC-cCCHHHHHHHHHHHHHHhhCCCC---C-cccc-cHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHh Confidence 35666777777 46778888999999888764221 0 0111 12345677777777778889999999999988652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNII-NLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll-~LL~s~~d~eVr~aA 704 (747) . ........+++.++..+.+ .+..++..++.+|..+........ ...++.+. .++.+. ++.++..+ T Consensus 81 ~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~-----~~~~~~l~~~~l~~~-~~~~r~~a 148 (237) T 4G3A_B 81 GSDFNAYTATVLPHVIDRLGD------SRDTVREKAQLLLRDLMEHRVLPP-----QALIDKLATSCFKHK-NAKVREEF 148 (237) T ss_dssp GGGGGGTHHHHHHHHHHHHTC------SCHHHHHHHHHHHHHHHHTTSSCH-----HHHHHHHHHHHTTCS-CHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCCCCH-----HHHHHHHHHHHhhCC-CHHHHHHH Confidence 1 1111112356666666655 356788888888888875311111 12345555 555544 56677777 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 149 ~~~l~~l~~~ 158 (237) T 4G3A_B 149 LQTIVNALHE 158 (237) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777776644 No 278 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=91.92 E-value=0.0062 Score=55.67 Aligned_cols=176 Identities=16% Similarity=0.152 Sum_probs=134.6 Template_Neff=11.800 Q NP_000290.2 528 CPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT----------------LEACAGALQNLTASK--GLMSSGMSQL 589 (747) Q Consensus 528 ~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV----------------r~~AL~aL~nLs~~s--~~~s~~~~~~ 589 (747) +-+++++++++.+..+++.|+++.|+.+|.. .+... +..++++|.+++... +. ... T Consensus 7 ~~~~~~~~~~~~~~~~~~~g~i~~L~~ll~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~-----~~~ 80 (252) T 5EWP_B 7 KLLSFTSNDILRFDKAYDENDVQEFVNLCSS-TCEIEKLEDRMHPWAADPKTIGALSATQLAILASKENEPH-----YKD 80 (252) T ss_dssp --CCCCCHHHHHHHHHHHTTCHHHHHHHTTC-CCBCCCC--CCCSSSCCCCBHHHHHHHHHHHHHTCTTCTH-----HHH T ss_pred HHHhccHHHHhhhHHHHhcCCHHHHHHHhcC-CChHHHHHHHhhhhhCCHHHHHHHHHHHHHHHhcCCCCHH-----HHH Confidence 4456899999999999999999999999983 33222 236888888888652 21 244 Q NP_000290.2 590 IGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRN 667 (747) Q Consensus 590 llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsn 667 (747) .+.+.++++.|+.++...++.++..++++|.+++.. ... ..+...++++.++.++.. .++.++..++++|.+ T Consensus 81 ~~~~~g~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~ 154 (252) T 5EWP_B 81 AIREANGIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMKS------NIDGMKAACAQTCRN 154 (252) T ss_dssp HHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHcccHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhhC------CCHHHHHHHHHHHHH Confidence 445778999999999888888999999999999986 443 344556788888888875 367889999999999 Q NP_000290.2 668 LMASQPQLAKQYFSSSMLNNIINLCRSSASP-------KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 668 La~~s~e~~~~Lve~giL~~Ll~LL~s~~d~-------eVr~aAL~aLsnL~~~~~ 716 (747) ++...+.....+.+.++++.|+.++... +. .++..++.+|.+++...+ T Consensus 155 l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~~~~a~~~l~~l~~~~~ 209 (252) T 5EWP_B 155 IFVLDKKYKKEFLKLGGITQLVNLLELP-SNYDDSQPLYTQLEAIYHLEDFILNDG 209 (252) T ss_dssp HHTTCHHHHHHHHHTTHHHHHHHTTSCC-TTCCSCSCCHHHHHHHHHHHHHHEETT T ss_pred HHhcCHHHHHHHHHCChHHHHHHHhcCC-CCCCCCchHHHHHHHHHHHHHHHhcCC Confidence 9875455666677778889999988765 33 378889999999987665 No 279 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=91.92 E-value=0.006 Score=54.09 Aligned_cols=147 Identities=7% Similarity=-0.004 Sum_probs=97.2 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .....++.++..+.+.+..++..++.++..+..... T Consensus 60 ~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 132 (240) T 4QMI_B 60 LPTALKGRLN-DSNKILVQQTLNILQQLAVAMGP-----NIKQ-HVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG 132 (240) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GCCCCCHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC Confidence 4566666676 46778888999999988764321 1111 123466777777777778888889999888875421 Q NP_000290.2 628 LHRVMGNQVF--PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI--~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ..++ +.+...+.+ .++.++..++.+|..++...... ... -..+++.+...+.+. +..++..++ T Consensus 133 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~-~~~-~~~~~~~l~~~l~~~-~~~vr~~a~ 198 (240) T 4QMI_B 133 M-----KEWLEGEDLSEELKK------ENPFLRQELLGWLAEKLPTLRST-PTD-LILCVPHLYSCLEDR-NGDVRKKAQ 198 (240) T ss_dssp S-----HHHHSSSHHHHHHTS------CCHHHHHHHHHHHHHHGGGCSSC-CGG-GGGGHHHHHHHTTCS-SHHHHHHHH T ss_pred h-----hHhccHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhCCCC-cHH-HHHHHHHHHHHHhcC-CHHHHHHHH Confidence 1 1234 555666655 36788888999998877543221 111 124567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 199 ~~l~~l~~~~ 208 (240) T 4QMI_B 199 DALPFFMMHL 208 (240) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHh Confidence 9998887653 No 280 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=91.92 E-value=0.006 Score=54.09 Aligned_cols=147 Identities=7% Similarity=-0.004 Sum_probs=97.2 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .....++.++..+.+.+..++..++.++..+..... T Consensus 60 ~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 132 (240) T 4QMJ_A 60 LPTALKGRLN-DSNKILVQQTLNILQQLAVAMGP-----NIKQ-HVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG 132 (240) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GCCCCCHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC Confidence 4566666676 46778888999999988764321 1111 123466777777777778888889999888875421 Q NP_000290.2 628 LHRVMGNQVF--PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI--~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ..++ +.+...+.+ .++.++..++.+|..++...... ... -..+++.+...+.+. +..++..++ T Consensus 133 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~-~~~-~~~~~~~l~~~l~~~-~~~vr~~a~ 198 (240) T 4QMJ_A 133 M-----KEWLEGEDLSEELKK------ENPFLRQELLGWLAEKLPTLRST-PTD-LILCVPHLYSCLEDR-NGDVRKKAQ 198 (240) T ss_dssp S-----HHHHSSSHHHHHHHS------SCHHHHHHHHHHHHHHGGGCSCC-CGG-GGGGHHHHHHHTTCS-SHHHHHHHH T ss_pred h-----hHhccHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhCCCC-cHH-HHHHHHHHHHHHhcC-CHHHHHHHH Confidence 1 1234 555666655 36788888999998877543221 111 124567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 199 ~~l~~l~~~~ 208 (240) T 4QMJ_A 199 DALPFFMMHL 208 (240) T ss_dssp HTHHHHHHHH T ss_pred HHHHHHHHHh Confidence 9998887653 No 281 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=91.84 E-value=0.0062 Score=58.52 Aligned_cols=153 Identities=14% Similarity=0.074 Sum_probs=87.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+. +.++.++..++.+|..++..... ....+ -..+++.+...+. +.++.++..++.++..++... T Consensus 235 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_A 235 LLPVLLSTAQ-EADPEVRSNAIFGMGVLAEHGGH-----PAQEH-FPKLLGLLFPLLARERHDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHHHHTS-CSSHHHHHHHHHHHHHHHHHHHH-----HHHTT-HHHHHHHHTTHHHHCCCHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhh-cCCHHHHHHHHHHHHHHHHhcCc-----hHHhh-HHHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHhC Confidence 4556666666 35677888888888888764321 11111 1346677777777 567788999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-SPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-d~eVr~aAL 705 (747) .... ....+++.+...+... ......+. ++.++..+....+......+ ..+++.+...+.+.. ...++..++ T Consensus 308 ~~~~-~~~~~~~~l~~~l~~~----~~~~~~~~-~~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~r~~~~ 380 (416) T 5XAH_A 308 PTRK-PEPQVLAALLHALPLK----EDLEEWVT-IGRLFSFLYQSSPDQVIDVA-PELLRICSLILADNKIPPDTKAALL 380 (416) T ss_dssp CSSC-CCHHHHHHHHHHCSCC----SCTTHHHH-HHHHHHHHHHHCSTTGGGSH-HHHHHTGGGTSSCTTSCHHHHHHHH T ss_pred CCCC-CHHHHHHHHHHhCCCC----CchhhHHH-HHHHHHHHHhcCchHHHhhH-HHHHHHHHHHHcCCCCCHHHHHHHH Confidence 1110 1123455555555221 01344555 77777777764332211111 134555666555431 235778888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 381 ~~l~~l~~~ 389 (416) T 5XAH_A 381 LLLTFLAKQ 389 (416) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888877643 No 282 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=91.84 E-value=0.0062 Score=58.52 Aligned_cols=153 Identities=14% Similarity=0.074 Sum_probs=87.3 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+. +.++.++..++.+|..++..... ....+ -..+++.+...+. +.++.++..++.++..++... T Consensus 235 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_C 235 LLPVLLSTAQ-EADPEVRSNAIFGMGVLAEHGGH-----PAQEH-FPKLLGLLFPLLARERHDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHSHH-----HHHTT-HHHHHHHHTHHHHHCCCHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHhh-cCCHHHHHHHHHHHHHHHHhcCc-----hHHhh-HHHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHhC Confidence 4556666666 35677888888888888764321 11111 1346677777777 567788999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-SPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-d~eVr~aAL 705 (747) .... ....+++.+...+... ......+. ++.++..+....+......+ ..+++.+...+.+.. ...++..++ T Consensus 308 ~~~~-~~~~~~~~l~~~l~~~----~~~~~~~~-~~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~r~~~~ 380 (416) T 5XAH_C 308 PTRK-PEPQVLAALLHALPLK----EDLEEWVT-IGRLFSFLYQSSPDQVIDVA-PELLRICSLILADNKIPPDTKAALL 380 (416) T ss_dssp CC---CCHHHHHHHHHHCSCC----SCGGGHHH-HHHHHHHHHHHCHHHHTTTH-HHHHHHHHHHHSCTTSCHHHHHHHH T ss_pred CCCC-CHHHHHHHHHHhCCCC----CchhhHHH-HHHHHHHHHhcCchHHHhhH-HHHHHHHHHHHcCCCCCHHHHHHHH Confidence 1110 1123455555555221 01344555 77777777764332211111 134555666555431 235778888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 381 ~~l~~l~~~ 389 (416) T 5XAH_C 381 LLLTFLAKQ 389 (416) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888877643 No 283 >2QK1_A Protein STU2; stu2, Stu2p, XMAP215, Dis1, TOG; 1.7A {Saccharomyces cerevisiae} Probab=91.81 E-value=0.0063 Score=53.79 Aligned_cols=152 Identities=9% Similarity=0.052 Sum_probs=95.7 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQN-LTASKGLMSSGMSQ--LIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~n-Ls~~s~~~s~~~~~--~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.++.++..++..|.. ++..... .. .. ....+++.+...+ .+.++.++..++.++..++ T Consensus 17 l~~~l~~~l~-~~~~~~r~~a~~~l~~~l~~~~~~-----~~~~~~-~~~~~~~~l~~~l~~d~~~~vr~~a~~~l~~l~ 89 (249) T 2QK1_A 17 LPKDFQERIT-SSKWKDRVEALEEFWDSVLSQTKK-----LKSTSQ-NYSNLLGIYGHIIQKDANIQAVALAAQSVELIC 89 (249) T ss_dssp SCTTHHHHHT-CSSHHHHHHHHHHHHHHTGGGCCC-----BCCTTC-CCHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHH T ss_pred CCHHHHHHHh-CCCHHHHHHHHHHHHHHHHhcCCC-----cCCCCc-cHHHHHHHHHHHHhhCcHHHHHHHHHHHHHHHH Confidence 4556666676 4677888899999998 7754221 01 01 1245677777888 7778889999999999888 Q NP_000290.2 624 RH-PL-LHR-VMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 624 ~~-~e-~~~-ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) .. .. ... .....+++.++..+.+ .+..++..++.++..+....+.. ..... ..+++.+...+.+. ++. T Consensus 90 ~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~ 161 (249) T 2QK1_A 90 DKLKTPGFSKDYVSLVFTPLLDRTKE------KKPSVIEAIRKALLTICKYYDPLASSGRN-EDMLKDILEHMKHK-TPQ 161 (249) T ss_dssp HHHCTTTSCHHHHHHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHHHSCTTCTTCTT-HHHHHHHHHHTTCS-SHH T ss_pred HHcCCCCCCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhChhcccCCH-HHHHHHHHHHhCCC-CHH Confidence 65 22 111 1122355666666655 35678888888888887542210 00111 23566666666655 677 Q NP_000290.2 700 AAEAARLLLSDMWSS 714 (747) Q Consensus 700 Vr~aAL~aLsnL~~~ 714 (747) ++..++.++..+... T Consensus 162 vr~~~~~~l~~~~~~ 176 (249) T 2QK1_A 162 IRMECTQLFNASMKE 176 (249) T ss_dssp HHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh Confidence 888888888777654 No 284 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=91.79 E-value=0.0063 Score=66.66 Aligned_cols=114 Identities=16% Similarity=0.088 Sum_probs=64.4 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.++.++..++.++..+...............+++.+...+.+ .+..++..++.++..++......... T Consensus 398 ~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 477 (1078) T 5H2V_A 398 ILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILE 477 (1078) T ss_dssp HHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHTTCCHHHHG T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhhccHHHHHHHHHhHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCChhhHH Confidence 34444445555566778888888887765432211101113455555555554 45677788888888777543221101 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....++..+...+. ..++.++..++.++..++.. T Consensus 478 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 512 (1078) T 5H2V_A 478 PYLDSLLTNLLVLLQ-SNKLYVQEQALTTIAFIAEA 512 (1078) T ss_dssp GGHHHHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHH Confidence 111245555666654 44566778888888877654 No 285 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=91.69 E-value=0.0072 Score=67.72 Aligned_cols=142 Identities=13% Similarity=0.056 Sum_probs=80.2 Template_Neff=11.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~~ 625 (747) .++.++.++. +.+..++..++.++..+...... ....+++.+...+.+.+.. ++..++++|+.+... T Consensus 442 ~~~~l~~~l~-~~~~~v~~~a~~~l~~i~~~~~~----------~~~~~~~~l~~~l~~~~~~~~v~~~a~~~L~~~~~~ 510 (939) T 6OWT_A 442 YVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNL 510 (939) T ss_pred HHHHHHHHhC-CCChhcCHHHHHHHHHHHhcCHH----------HHHhHHHHHHHHhcCCCCcHHHHHHHHHHHHHHHHh Confidence 5666777776 35556777777777776643211 1234556666667654444 778888888877654 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKAA 701 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eVr 701 (747) . .........++..|...+.. .+..++..++.+|..++...+.. ...+..++..+ .+. +.+++ T Consensus 511 ~~~~~~~~~~~~~~~L~~~l~~------~~~~vr~~al~aL~~l~~~~~~~------~~~i~~ll~~l~~~~~~-d~evr 577 (939) T 6OWT_A 511 IAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPEV------KATIQDVLRSDSQLKNA-DVELQ 577 (939) T ss_pred cCCCCCCCHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhChhh------HhHHHHHHHHhcccCCC-CHHHH Confidence 1 11100111244455555554 25677888888888887643221 12334444433 333 66777 Q NP_000290.2 702 EAARLLLSDMWS 713 (747) Q Consensus 702 ~aAL~aLsnL~~ 713 (747) ..++.++..+.. T Consensus 578 ~~a~~~l~~l~~ 589 (939) T 6OWT_A 578 QRAVEYLRLSTV 589 (939) T ss_pred HHHHHHHHHHcC Confidence 777777766553 No 286 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=91.69 E-value=0.0066 Score=64.52 Aligned_cols=160 Identities=8% Similarity=0.007 Sum_probs=89.0 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~ 625 (747) .++.++..+..+.++.++..++.+|..++..... ....+ -..+++.+...+.+. ++.++..++.++..++.. T Consensus 650 ~~~~l~~~l~~~~~~~vr~~~~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~v~~~a~~~l~~l~~~ 723 (876) T 2P8Q_A 650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQS-----NIIPF-CDEVMQLLLENLGNENVHRSVKPQILSVFGDIALA 723 (876) T ss_dssp HHHHHHHHHHCCSSHHHHHHHHHHHHHHHHHHGG-----GGHHH-HHHHHHHHHHHTSCSSSCTTHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhccccHHHHHHHHHHHHHHHHHHhh-----cchHh-HHHHHHHHHHHHcCcCcccchHhHHHHHHHHHHHH Confidence 3455555555225667888888888888754221 01111 135677777777766 678888999999888865 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTG-----NTSNSEDILSSACYTVRNLMASQPQLAKQYFS-----SSMLNNIINLCR 693 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~-----~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-----~giL~~Ll~LL~ 693 (747) ... ..++ ..+++.+...+..... ....+..++..++.++..++.........+.. ...++.++..+. T Consensus 724 ~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~ 802 (876) T 2P8Q_A 724 IGGEFKKYL-EVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFID 802 (876) T ss_dssp HGGGGHHHH-HHHHHHHHHHHSCCCCTTCSTTHHHHHHHHHHHHHHHHHHHHHHSCSSCSCCCGGGGTGGGHHHHHHHHH T ss_pred hchhhHHHH-HHHHHHHHHHHHccCCCCchHHHHHHHHHHHHHHHHHHHHHHHHhcCcccCCCchhhHHHhHHHHHHHHH Confidence 211 1111 2345555555443100 00014667888888888887621111111100 011444444443 Q NP_000290.2 694 ------SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 694 ------s~~d~eVr~aAL~aLsnL~~~~ 715 (747) +. +..++..++.++..++..- T Consensus 803 ~~~~~~~~-~~~v~~~~~~~l~~l~~~~ 829 (876) T 2P8Q_A 803 HIAGDEDH-TDGVVACAAGLIGDLCTAF 829 (876) T ss_dssp HHHHSSCC-CHHHHHHHHHHHHHHHHHH T ss_pred HHhCCCCC-ChhHHHHHHHHHHHHHHHh Confidence 33 5778888888888877543 No 287 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=91.65 E-value=0.0068 Score=51.30 Aligned_cols=157 Identities=18% Similarity=0.285 Sum_probs=121.2 Template_Neff=13.100 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.++.++..+. +.++.++..++..|.+++...+. ....+.+.++++.|..++.+.++.++..++++|.+++.. T Consensus 3 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 76 (202) T 5MFO_F 3 GSELPQMVQQLN-SPDQQELQSALRKLSQIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASG 76 (202) T ss_dssp CTTHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTS T ss_pred CchHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcC Confidence 456788888887 47778888999999999875332 233445678899999999988889999999999999976 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. +..++.. T Consensus 77 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 149 (202) T 5MFO_F 77 GNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQE 149 (202) T ss_dssp CHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHH T ss_pred CHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHH Confidence 333 334455678888888866 3678888999999999876455555556667888888888866 7888999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|.+++... T Consensus 150 ~~~~l~~l~~~~ 161 (202) T 5MFO_F 150 ALWALSNIASGG 161 (202) T ss_dssp HHHHHHHHTTSC T ss_pred HHHHHHHHhcCh Confidence 999999998765 No 288 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=91.58 E-value=0.007 Score=51.19 Aligned_cols=157 Identities=18% Similarity=0.285 Sum_probs=120.0 Template_Neff=13.100 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.++.++..+. +.++.++..++..|.+++...+. ....+.+.++++.|..++.+.++.++..++++|.+++.. T Consensus 3 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 76 (202) T 5MFO_E 3 GSELPQMVQQLN-SPDQQELQSALRKLSQIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASG 76 (202) T ss_dssp --CHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTS T ss_pred CchHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcC Confidence 456788888887 47778888999999999875332 233445678899999999988889999999999999976 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) +.. ..+...++++.+...+.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. +..++.. T Consensus 77 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 149 (202) T 5MFO_E 77 GNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQE 149 (202) T ss_dssp CHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHH T ss_pred CHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHH Confidence 333 333455678888888866 3678888999999999876455555555667888888888876 7888999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|.+++... T Consensus 150 ~~~~l~~l~~~~ 161 (202) T 5MFO_E 150 ALWALSNIASGG 161 (202) T ss_dssp HHHHHHHHHTSC T ss_pred HHHHHHHHhcCH Confidence 999999998765 No 289 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=91.50 E-value=0.0073 Score=62.82 Aligned_cols=159 Identities=8% Similarity=0.020 Sum_probs=86.8 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+....++.++..++.++..++..... ....+ -..+++.+...+.+. ++.++..++.++..++.. T Consensus 525 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~~v~~~~~~~l~~l~~~ 598 (762) T 2QNA_A 525 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQS-----NIIPF-CDEVMQLLLENLGNENVHRSVKPQILSVFGDIALA 598 (762) T ss_pred HHHHHHHHhCCCCCHHHHHHHHHHHHHHHHHhHH-----cchHh-HHhHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHH Confidence 4555665565224567788888888888754221 01111 135667777777765 567888899999888765 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGN-----TSNSEDILSSACYTVRNLMASQPQLAKQYFS-----SSMLNNIINLCR 693 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~-----~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-----~giL~~Ll~LL~ 693 (747) ... ..++ ..+++.+...+...... ...+..++..++.++..++...+.....+.. ...++.++.++. T Consensus 599 ~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~ 677 (762) T 2QNA_A 599 IGGEFKKYL-EVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFID 677 (762) T ss_pred hhcchHHHH-HHHHHHHHHHHcCCCCCCCcccCCCCHHHHHHHHHHHHHHHHhCCCCCcCccccHHHHHhHHHHHHHHHH Confidence 211 1111 23445555554421000 0014566778888888887642221111100 011344444443 Q NP_000290.2 694 ------SSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 694 ------s~~d~eVr~aAL~aLsnL~~~ 714 (747) +. +..++..++.+|..++.. T Consensus 678 ~~~~~~~~-~~~~~~~a~~~l~~l~~~ 703 (762) T 2QNA_A 678 HIAGDEDH-TDGVVACAAGLIGDLCTA 703 (762) T ss_pred HHcCCCCC-CHHHHHHHHHHHHHHHHH Confidence 22 467788888888887754 No 290 >6G4J_B Probable serine/threonine-protein kinase YabT (E.C.2.7.11.1); Bacterial Hanks-type protein kinase, complex; 1.599A {Bacillus subtilis (strain 168)} Probab=91.47 E-value=0.008 Score=50.62 Aligned_cols=132 Identities=14% Similarity=0.147 Sum_probs=85.5 Template_Neff=11.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) ..+.+++++. +.++.++..++..+..+.. ...++.+..++.+.++.++..++.++..+... T Consensus 15 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 75 (148) T 6G4J_B 15 KVEMYIKNLQ-DDSAVVRDYAAAALGKIGD----------------ERAVEPLIKALKDEDEYVRQSAAWALGEIGDE-- 75 (148) T ss_pred cHHHHHHHhc-CCCHHHHHHHHHHHHhhCC----------------HHHHHHHHHHhCCCCHHHHHHHHHHHHHhCCH-- Confidence 4566777777 4667777777777765532 12344556667677788888888888877542 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... ..++.+..++.+. ++.++..++.+ T Consensus 76 -------~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 130 (148) T 6G4J_B 76 -------RAVEPLIKALKD------EDPSVRLTAAEALGQIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 130 (148) T ss_pred -------HHHHHHHHHhcC------CCHHHHHHHHHHHHhhCCH-----------HHHHHHHHHhcCC-CHHHHHHHHHH Confidence 234455555554 3567888888888876531 2344555566555 67888999999 Q NP_000290.2 708 LSDMWSSKELQGVLRQ 723 (747) Q Consensus 708 LsnL~~~~~~~~~~~~ 723 (747) |..+........-+++ T Consensus 131 L~~~~~~~~~~~~~~~ 146 (148) T 6G4J_B 131 LETHKSLISGGGGSGG 146 (148) T ss_pred HHhhCCCChHhccccc Confidence 9888766555444443 No 291 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=91.29 E-value=0.0081 Score=65.72 Aligned_cols=98 Identities=9% Similarity=0.152 Sum_probs=58.6 Template_Neff=13.000 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLN 686 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~ 686 (747) ..++..++.++..++.... . .... ..+++.+...+.+ .++.++..++.+|..++...+...... ...+++ T Consensus 821 ~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~-~~~~~~ 892 (1078) T 3W3W_A 821 EDLLDEINKSIAAVLKTTNGHYLKNL-ENIWPMINTFLLD------NEPILVIFALVVIGDLIQYGGEQTASM-KNAFIP 892 (1078) T ss_dssp HHHHHHHHHHHHHHHHHHTTTHHHHH-GGGHHHHHHHHC--------CHHHHHHHHHHHHHHHTC--CCCHHH-HHHHHH T ss_pred HHHHHHHHHHHHHHHHhcccchHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhcchhhHHH-HHhHHH Confidence 3455666677776665411 1 1111 2345556666554 356788888899988876432221111 124567 Q NP_000290.2 687 NIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 687 ~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+. ++.++..++.+|..++... T Consensus 893 ~l~~~l~~~-~~~vr~~a~~~l~~l~~~~ 920 (1078) T 3W3W_A 893 KVTECLISP-DARIRQAASYIIGVCAQYA 920 (1078) T ss_dssp HHHHHHTCS-CHHHHHHHHHHHHHHHHHS T ss_pred HHHHHhcCC-CHHHHHHHHHHHHHHHHHC Confidence 777777766 7889999999998888653 No 292 >3ND2_A Importin subunit beta-1; importin, karyopherin, nuclear import, receptor; 2.4A {Saccharomyces cerevisiae} Probab=91.23 E-value=0.0083 Score=63.25 Aligned_cols=152 Identities=13% Similarity=0.136 Sum_probs=86.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+.. .+ ..++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. T Consensus 598 ~~~~l~~~l~~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 670 (861) T 3ND2_A 598 LMGLFFRLLEK-KDSAFIEDDVFYAISALAASLGK-----GFEK-YLETFSPYLLKALNQVDSPVSITAVGFIADISNSL 670 (861) T ss_dssp HHHHHHHHHHS-TTHHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHHTCTTSTHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhc-CCCchhHHHHHHHHHHHHHHhhh-----hHHH-HHHhHHHHHHHHHcCCCchHHHHHHHHHHHHHHHc Confidence 45555666652 33 55777888888887754221 0111 1235677777777777778888999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASP------ 698 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~------ 698 (747) +.. .... ..+++.+...+... ..+..++..++.++..++...+....... ..+++.+...+... .. T Consensus 671 ~~~~~~~~-~~~~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~-~~~~~~~~ 743 (861) T 3ND2_A 671 EEDFRRYS-DAMMNVLAQMISNP----NARRELKPAVLSVFGDIASNIGADFIPYL-NDIMALCVAAQNTK-PENGTLEA 743 (861) T ss_dssp TTSSHHHH-HHHHHHHHHHHHCT----TCCTTHHHHHHHHHHHHHHHHGGGGGGGH-HHHHHHHHHHHTCC-CSSSSHHH T ss_pred chhhHHhH-HHHHHHHHHHHhCc----chhhhhHHHHHHHHHHHHHHcchhcHHHH-HHHHHHHHHHHccC-CCCCCHHH Confidence 211 1111 23555555555541 01467788888999888765332111111 23455555555433 21 Q NP_000290.2 699 -----KAAEAARLLLSDMWS 713 (747) Q Consensus 699 -----eVr~aAL~aLsnL~~ 713 (747) .++..++.++..++. T Consensus 744 ~~~~~~~~~~~l~~l~~~~~ 763 (861) T 3ND2_A 744 LDYQIKVLEAVLDAYVGIVA 763 (861) T ss_dssp HHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 455566666655443 No 293 >5OWU_A Importin subunit beta-1, Nucleoporin NUP1; nuclear transport, TRANSPORT PROTEIN; 2.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=91.23 E-value=0.0083 Score=63.25 Aligned_cols=152 Identities=13% Similarity=0.136 Sum_probs=86.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+.. .+ ..++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. T Consensus 598 ~~~~l~~~l~~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 670 (861) T 5OWU_A 598 LMGLFFRLLEK-KDSAFIEDDVFYAISALAASLGK-----GFEK-YLETFSPYLLKALNQVDSPVSITAVGFIADISNSL 670 (861) T ss_dssp HHHHHHHHHHS-TTGGGTHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHHHCTTSTHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHhc-CCCchhHHHHHHHHHHHHHHhhh-----hHHH-HHHhHHHHHHHHHcCCCchHHHHHHHHHHHHHHHc Confidence 45555666652 33 55777888888887754221 0111 1235677777777777778888999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASP------ 698 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~------ 698 (747) +.. .... ..+++.+...+... ..+..++..++.++..++...+....... ..+++.+...+... .. T Consensus 671 ~~~~~~~~-~~~~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~-~~~~~~~~ 743 (861) T 5OWU_A 671 EEDFRRYS-DAMMNVLAQMISNP----NARRELKPAVLSVFGDIASNIGADFIPYL-NDIMALCVAAQNTK-PENGTLEA 743 (861) T ss_dssp GGGGHHHH-HHHHHHHHHHHTCT----TCCTTHHHHHHHHHHHHHHHHGGGGHHHH-HHHHHHHHHHHTCC-CSSSSHHH T ss_pred chhhHHhH-HHHHHHHHHHHhCc----chhhhhHHHHHHHHHHHHHHcchhcHHHH-HHHHHHHHHHHccC-CCCCCHHH Confidence 211 1111 23555555555541 01467788888999888765332111111 23455555555433 21 Q NP_000290.2 699 -----KAAEAARLLLSDMWS 713 (747) Q Consensus 699 -----eVr~aAL~aLsnL~~ 713 (747) .++..++.++..++. T Consensus 744 ~~~~~~~~~~~l~~l~~~~~ 763 (861) T 5OWU_A 744 LDYQIKVLEAVLDAYVGIVA 763 (861) T ss_dssp HHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 455566666655443 No 294 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=90.97 E-value=0.011 Score=70.63 Aligned_cols=159 Identities=14% Similarity=0.083 Sum_probs=104.1 Template_Neff=9.900 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATL-EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL---QSGNSDVVRSGASLLSN 621 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr-~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL---~s~d~eVr~~AL~aLsn 621 (747) ..+++.|+.+|. +.++.++ ..|+.+|..+...... ......+...++++.|+.+| .+.++.++..++.+|.. T Consensus 463 ~~~i~~L~~~l~-d~~~~vR~~~a~~~L~~l~~~~~~---~~~~~~~~~~~~lp~Li~~L~~~~d~~~~vr~~aa~~l~~ 538 (1460) T 5DFZ_B 463 DRVVPYFVCCFE-DSDQDVQALSLLTLIQVLTSVRKL---NQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSD 538 (1460) T ss_pred ccchHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCCCc---cCCccccCcCChHHHHHHHHHhccCCCHHHHHHHHHHHHH Confidence 457888999998 5788888 8999999988764221 00011223467899999999 88889999999999998 Q NP_000290.2 622 MSRHP--L-----------L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 687 (747) Q Consensus 622 La~~~--e-----------~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~ 687 (747) +.... . . ...+..++++.+..++...- ...++.++..|+.+|..|+...... .....+++. T Consensus 539 ~~~~~~~~~l~~l~~~~~~~~~~~l~~~~~~~l~~ll~~~l--~d~~~~VR~~A~~aL~~l~~~~~~~---~~~~~~l~~ 613 (1460) T 5DFZ_B 539 LAIIINRFQEFTFAQHCNDNSSTKYSAKLIQSVEDLTVSFL--TDNDTYVKMALLQNILPLCKFFGRE---RTNDIILSH 613 (1460) T ss_pred HHHHcCHHHHHHHHHhcccChhHHHHcChHHHHHHHHHHHh--cCCCHHHHHHHHHHHHHHhcccccc---ccHHhHHHH Confidence 85430 0 0 01122234444444433200 0036789999999999987542111 111356778 Q NP_000290.2 688 IINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 688 Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) |+.++.+. ++.+|..|+.+|..+... T Consensus 614 Li~ll~d~-~~~VR~~a~~aL~~i~~~ 639 (1460) T 5DFZ_B 614 LITYLNDK-DPALRVSLIQTISGISIL 639 (1460) T ss_pred HHHHhcCC-CHHHHHHHHHHHHHHHhh Confidence 88888776 788888888888888763 No 295 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=90.68 E-value=0.011 Score=64.69 Aligned_cols=157 Identities=9% Similarity=0.025 Sum_probs=84.5 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++..+..+.+..++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.+|..++.... T Consensus 440 ~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~ 514 (1078) T 3W3U_A 440 ILPALISKLTSECTSRVQTHAAAALVAFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAK 514 (1078) T ss_dssp HHHHHHHHSSTTSCHHHHHHHHHHHHHHHTTCCH---H-HHGG-GHHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHcCCCCCHHHHHHHHHHHHHHHHhCCh---h-hhHH-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhH Confidence 4555666665224566777888888888764221 0 0111 123566677777777778888899999988876521 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR---SSASPKAAEA 703 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~---s~~d~eVr~a 703 (747) ........+++.+...+.... ..++.++..++.++..+................++.+..++. +. +..++.. T Consensus 515 ~~~~~~~~~~~~~l~~~l~~~~---~~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~-~~~~~~~ 590 (1078) T 3W3U_A 515 NKFIKYYDTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDE-DDALRSY 590 (1078) T ss_dssp GGGGGGHHHHHHHHHHHHHCC-------HHHHHHHHHHHHHHHHHHCHHHHTTTHHHHHHHHHHHHTSSCCC-CHHHHHH T ss_pred HhHHHHHhhHHHHHHHHHhcCC---CCcchHHHHHHHHHHHHHHHHCHHHhHHHHHHHHHHHHHHhcCCCCC-CHHHHHH Confidence 111111234555555554310 014567777888888776532111100011123444444444 23 4566777 Q NP_000290.2 704 ARLLLSDMWS 713 (747) Q Consensus 704 AL~aLsnL~~ 713 (747) ++.++..++. T Consensus 591 ~~~~l~~l~~ 600 (1078) T 3W3U_A 591 LEQSWSRICR 600 (1078) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777766654 No 296 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=90.57 E-value=0.011 Score=62.78 Aligned_cols=113 Identities=11% Similarity=0.140 Sum_probs=66.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL-E 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~-~ 324 (747) +++.+...+.+.++.++..++.++..++..............+++.+...+.+.+..++..++.++..++........ . T Consensus 367 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 446 (876) T 1QGR_A 367 VLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAIND 446 (876) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCCHHhcHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhCChhhcCC Confidence 344444555556677788888888887764322111111234556666666666778888899998888764432110 1 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. + ++.++..++.++..+... T Consensus 447 ~~~~~~~~~l~~~l~-~-~~~v~~~a~~~l~~l~~~ 480 (876) T 1QGR_A 447 VYLAPLLQCLIEGLS-A-EPRVASNVCWAFSSLAEA 480 (876) T ss_pred chHHHHHHHHHHHhc-C-CHHHHHHHHHHHHHHHHH Confidence 112245566666665 3 566777777777777653 No 297 >4QMH_A LP04448p; PROTEIN BINDING, TOG DOMAIN; 1.652A {Drosophila melanogaster} Probab=90.39 E-value=0.012 Score=51.77 Aligned_cols=149 Identities=9% Similarity=0.047 Sum_probs=95.9 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.+..++..++.+|..++.... T Consensus 58 ~~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 130 (241) T 4QMH_A 58 LAPALAHRLV-DSNAKIAQTTLAICEQLATAMGA-----GCRN-HVRNLFPGFLHALGDNKSFVRAAALNCINSFGEKGG 130 (241) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhcC Confidence 4556666676 46778888999999988764221 1111 113566777777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPE--VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~~~ll~~giI~~--Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..+++. +...+.+ .++.++..++.++..++...+.... ......+++.+...+.+. ++.++..+ T Consensus 131 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a 198 (241) T 4QMH_A 131 Y-----KEFFESEMIADALKG------GSPALKTELWAWLADKLPGLPPKSVSKEDIHSMVPHLYAHICDR-NADVRKNA 198 (241) T ss_dssp S-----GGGSSTTHHHHHHHT------CCHHHHHHHHHHHHHHGGGSCGGGSCHHHHHHHHHHHHHHTTCS-SHHHHHHH T ss_pred h-----HHhcCHHHHHHHHhC------CCHHHHHHHHHHHHHhccCCCcccCCHHHHHhHHHHHHHHHhCC-CHHHHHHH Confidence 1 123333 5555554 3677888899999888764322110 011124567777777766 78899999 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.++..+.... T Consensus 199 ~~~l~~l~~~~ 209 (241) T 4QMH_A 199 NEAVLGIMIHL 209 (241) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHHh Confidence 99998887543 No 298 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=90.35 E-value=0.013 Score=64.93 Aligned_cols=102 Identities=12% Similarity=0.008 Sum_probs=64.4 Template_Neff=10.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..++..+...+.+.+..++..+..++..+....+.. ..+++.+...+.+.+..++..++.++..+.... T Consensus 67 ~~l~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~------~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~----- 135 (874) T 5A1V_E 67 TEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV------IIVTSSLTKDMTGKEDNYRGPAVRALCQITDST----- 135 (874) T ss_dssp HHHHHHHHHGGGSCCHHHHHHHHHHHHHHHTSCSCG------GGHHHHHHHHHHSSSHHHHHHHHHHHHHHCCHH----- T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHhcccCchH------hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHH----- Confidence 345556666677777788888888887776532211 234555666666667778888888887664211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ....++..+...+. +.++.++..++.++..+.. T Consensus 136 --~~~~l~~~l~~~l~-d~~~~Vr~~a~~~l~~l~~ 168 (874) T 5A1V_E 136 --MLQAVERYMKQAIV-DKVPSVSSSALVSSLHLLK 168 (874) T ss_dssp --HHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHH T ss_pred --HHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 01234455555665 5567788888888887765 No 299 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=90.35 E-value=0.013 Score=64.93 Aligned_cols=102 Identities=12% Similarity=0.008 Sum_probs=64.4 Template_Neff=10.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..++..+...+.+.+..++..+..++..+....+.. ..+++.+...+.+.+..++..++.++..+.... T Consensus 67 ~~l~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~------~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~----- 135 (874) T 5NZR_G 67 TEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV------IIVTSSLTKDMTGKEDNYRGPAVRALCQITDST----- 135 (874) T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHhcccCchH------hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHH----- Confidence 345556666677777788888888887776532211 234555666666667778888888887664211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ....++..+...+. +.++.++..++.++..+.. T Consensus 136 --~~~~l~~~l~~~l~-d~~~~Vr~~a~~~l~~l~~ 168 (874) T 5NZR_G 136 --MLQAVERYMKQAIV-DKVPSVSSSALVSSLHLLK 168 (874) T ss_pred --HHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 01234455555665 5567788888888887765 No 300 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=90.26 E-value=0.013 Score=64.05 Aligned_cols=157 Identities=10% Similarity=0.054 Sum_probs=83.5 Template_Neff=13.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+....++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 439 ~~~~~l~~~l~~~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~i~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 513 (1078) T 3W3W_A 439 RILPALISKLTSECTSRVQTHAAAALVNFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAA 513 (1078) T ss_dssp HHHHHHHHHTSTTSCHHHHHHHHHHHHHHHHTCCH---H-HHGG-GHHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCCh---h-hHHH-HHHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHh Confidence 35566666665224567778888888887764221 0 0011 11355666777777667788888999998887652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR---SSASPKA 700 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~---s~~d~eV 700 (747) . . .... ..+++.+...+.... ..++.++..++.++..++.... ...... ...++..+...+. +. +..+ T Consensus 514 ~~~~~~~~-~~~~~~l~~~l~~~~---~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~-~~~v 587 (1078) T 3W3W_A 514 KNKFIKYY-DTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEH-SQELISILVALQNSDIDE-DDAL 587 (1078) T ss_dssp GGGGGGGH-HHHHHHHHHHHHCC-------HHHHHHHHHHHHHHHHHHCHHHHTTT-HHHHHHHHHHHHTCC------HH T ss_pred HHhHHHHH-HhHHHHHHHHHHhCC---CCChHHHHHHHHHHHHHHHHHChhhhhHH-HHHHHHHHHHHhCCCCCC-chHH Confidence 1 1 1111 234555555554310 0145677778888888765321 111111 1123444444444 23 4566 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 588 ~~~~~~~l~~l~~~ 601 (1078) T 3W3W_A 588 RSYLEQSWSRICRI 601 (1078) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 77777777666543 No 301 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=90.24 E-value=0.013 Score=64.03 Aligned_cols=158 Identities=9% Similarity=0.045 Sum_probs=84.1 Template_Neff=13.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+....++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 439 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 513 (1078) T 5H2V_A 439 RILPALISKLTSECTSRVQTHAAAALVNFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAA 513 (1078) T ss_dssp HHHHHHHHTTSTTSCHHHHHHHHHHHHHHHTTCCH---H-HHGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCCh---h-hHHH-HHHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHHh Confidence 35566666665224567778888888888764221 0 0011 12356666777777677788889999998887652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR---SSASPKAA 701 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~---s~~d~eVr 701 (747) . . .... ..+++.+...+.... ..++.++..++.++..++..............+++.+...+. +. +..++ T Consensus 514 ~~~~~~~~-~~~~~~l~~~l~~~~---~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~-~~~v~ 588 (1078) T 5H2V_A 514 KNKFIKYY-DTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDE-DDALR 588 (1078) T ss_dssp GGGGGGGH-HHHHHHHHHHHTCC-------HHHHHHHHHHHHHHHHHHCHHHHTTTHHHHHHHHHHHHTCC------CHH T ss_pred HHHHHHHH-HhHHHHHHHHHHhCC---CCChHHHHHHHHHHHHHHHHHCchhhhHHHHHHHHHHHHHhCCCCCC-chHHH Confidence 1 1 1111 234555555554310 014567778888888876532111000011123444444444 23 45666 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..++.++..++.. T Consensus 589 ~~~~~~l~~l~~~ 601 (1078) T 5H2V_A 589 SYLEQSWSRICRI 601 (1078) T ss_dssp HHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHH Confidence 7777777666543 No 302 >4NEE_G AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=90.08 E-value=0.014 Score=56.75 Aligned_cols=141 Identities=15% Similarity=0.147 Sum_probs=95.0 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+++.+..... T Consensus 77 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 145 (398) T 4NEE_G 77 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 145 (398) T ss_dssp CHHHHHHHHT-CSSHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHHH T ss_pred hHHHHHHHHc-CCCccHHHHHHHHHHHHcCCCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHhcCCHHH Confidence 4566777777 46778888888888888764221 1 12356667777777888899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+.. +.....++.+...+.+. ++.++..++ T Consensus 146 -----~~~~~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 210 (398) T 4NEE_G 146 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 210 (398) T ss_dssp -----HHHHTTHHHHHHHCSS------SCHHHHHHHHHHHHHHHHHCGGG---SCCSSHHHHHHGGGGCS-CHHHHHHHH T ss_pred -----HHHHHHhHHHHHhcCC------CCHHHHHHHHHHHHHHHHHChhh---ccccchHHHHHHHhcCC-CHHHHHHHH Confidence 112455566666 54 36788999999999987643221 11234567777777665 678888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 211 ~~l~~l~~~ 219 (398) T 4NEE_G 211 SLITTLAQK 219 (398) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888887764 No 303 >6MQ5_A CLIP-associating protein 1; Microtubule Plus End Binding, STRUCTURAL; HET: MSE; 2.146A {Homo sapiens} Probab=89.98 E-value=0.015 Score=52.93 Aligned_cols=111 Identities=16% Similarity=0.126 Sum_probs=61.3 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQL----IGLKEKGLPQIA-RLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~----llie~giI~~Ll-~LL~s~d~eVr~~AL~aLsnL 622 (747) .++.++..+. +.++.++..++..|..++..... ... ......+++.+. .++.+.++.++..++.++..+ T Consensus 4 ~l~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~~~~~~~~~~~~~l~~~~l~d~~~~vr~~a~~~l~~l 77 (257) T 6MQ5_A 4 RMESCLAQVL-QKDVGKRLQVGQELIDYFSDKQK-----SADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSAL 77 (257) T ss_dssp SHHHHHHHHH-CCCHHHHHHHHHHHHHHHHCTTT-----TTTTTTCHHHHHHHHHHCCCCCTTCSSHHHHHHHHHHHHHH T ss_pred hHHHHHHHHh-cCCHHHHHHHHHHHHHHHhcccc-----ccccccCHHHHHHHHHHHHHHHhcCCcHHHHHHHHHHHHHH Confidence 3555666676 46778888888888888764321 010 001234555555 456667778888899988888 Q NP_000290.2 623 SRHP-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 623 a~~~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +... .........+++.++..+.+ .+..++..++.+|..+.. T Consensus 78 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~ 120 (257) T 6MQ5_A 78 VTRLQDRFKAQIGTVLPSLIDRLGD------AKDSVREQDQTLLLKIMD 120 (257) T ss_dssp HHHHGGGGHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHHHHHH T ss_pred HHHhHHHHHHHHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 7651 11000111244444444443 234455555555555543 No 304 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=89.98 E-value=0.015 Score=60.62 Aligned_cols=109 Identities=11% Similarity=0.011 Sum_probs=67.1 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+..........+++.+...+.+.+..++..++.++..+....... T Consensus 160 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~L~~l~~~~~~~--- 236 (657) T 4UQI_B 160 GFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDRE--- 236 (657) T ss_pred chHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCChhhhhhhhhcHHHHHHHHhcCCCHHHHHHHHHHHHhhCCCCHHH--- Confidence 34556666666777788888888888887653321111112345566666666666677777888887776432211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...+++.+...+. +.++.++..++.++..+.. T Consensus 237 --~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 268 (657) T 4UQI_B 237 --AQSICERVTPRLS-HANSAVVLSAVKVLMKFLE 268 (657) T ss_pred --HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 1234555556665 4566778888888877765 No 305 >4XRI_A Importin Beta; Transport Protein, Nuclear Transport, Transport; HET: GOL, SO4; 2.05A {Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)} Probab=89.95 E-value=0.014 Score=61.52 Aligned_cols=159 Identities=9% Similarity=0.055 Sum_probs=88.2 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS--GNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s--~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+...+....+..++..++.++..++..... ....+ -..+++.+...+.+ .+..++..++.++..++.. T Consensus 651 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~~~ 724 (882) T 4XRI_A 651 FAPFLYNALGNQEEPSLCSMAIGLVSDVTRSLGE-----RSQPY-CDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASA 724 (882) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhhh-----ccHhh-HHHHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHh Confidence 4566666665214566777888888877654221 01111 13466677777766 5677888999999988865 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGN------TSNSEDILSSACYTVRNLMASQPQL-----AKQYFSSSMLNNIINLC 692 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~------~~~d~eVr~~Al~aLsnLa~~s~e~-----~~~Lve~giL~~Ll~LL 692 (747) +.. ..++ ..+++.+...+...... ......++..++.++..++...... ...+. ..+++.+...+ T Consensus 725 ~~~~~~~~~-~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~-~~i~~~l~~~~ 802 (882) T 4XRI_A 725 IGGHFETYL-TIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYV-ESIFALLNSIA 802 (882) T ss_pred CCcccHhHH-HHHHHHHHHHhcCCCCCCCCccccccCHHHHHHHHHHHHHHHHhcChhcchhhchhcH-HhHHHHHHHHh Confidence 211 1111 22444444444321000 0003456667777777776532211 11111 23456666666 Q NP_000290.2 693 RSSAS--PKAAEAARLLLSDMWSSK 715 (747) Q Consensus 693 ~s~~d--~eVr~aAL~aLsnL~~~~ 715 (747) .+. + ..++..++.++..++... T Consensus 803 ~~~-~~~~~vr~~a~~~l~~l~~~~ 826 (882) T 4XRI_A 803 NDP-NRSEALMRASMGVIGDLADAY 826 (882) T ss_pred cCC-CCCHHHHHHHHHHHHHHHHHh Confidence 654 4 788889999998887543 No 306 >4NEE_B AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=89.83 E-value=0.016 Score=56.57 Aligned_cols=141 Identities=15% Similarity=0.147 Sum_probs=94.8 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. +++..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|+.+..... T Consensus 77 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 145 (398) T 4NEE_B 77 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 145 (398) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHhcccCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHhhCCHHH Confidence 4566777776 46778888888888888764221 1 12356667777777888899999999987764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+.. +.....++.+...+.+. ++.++..++ T Consensus 146 -----~~~~~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 210 (398) T 4NEE_B 146 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 210 (398) T ss_pred -----HHHHHHHHHHHHcCCC------CCHHHHHHHHHHHHHHHHHChhH---hcHhhHHHHHHHHhcCC-CHHHHHHHH Confidence 112455566666 54 36788999999999987643221 11234567777777665 778888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 211 ~~l~~l~~~ 219 (398) T 4NEE_B 211 SLITTLAQK 219 (398) T ss_pred HHHHHHHHh Confidence 888887764 No 307 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=89.78 E-value=0.015 Score=61.60 Aligned_cols=153 Identities=8% Similarity=0.015 Sum_probs=85.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .+..+...+. +....++..++.++..+...... ...... ....+++.+...+.+. ..++..++.+|..++.... T Consensus 397 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~---~~~~~~-~~~~~~~~l~~~l~~~-~~~~~~a~~~l~~l~~~~~ 470 (852) T 6EN4_C 397 IISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA---ADIDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNALG 470 (852) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCh---hhcCHH-HHHHHHHHHHHhcCCC-HHHHHHHHHHHHHHHHcCC Confidence 3445555555 34556677777777777653221 000011 1123445555555433 4677888888888876521 Q NP_000290.2 628 -L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 -~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .... ..+++.+...+.+ .++.++..++.++..++..............+++.+...+.+. +..++..++ T Consensus 471 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~ 542 (852) T 6EN4_C 471 KRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSIL 542 (852) T ss_pred hhhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhChhhcCHHHHHhHHHHHHHHccCC-CHHHHHHHH Confidence 1 1111 2345556666655 3678888999999988864322111112223566666666655 667788888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..++.. T Consensus 543 ~~l~~l~~~ 551 (852) T 6EN4_C 543 GALKAIVNV 551 (852) T ss_pred HHHHHHHHh Confidence 888777654 No 308 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=89.57 E-value=0.018 Score=63.83 Aligned_cols=141 Identities=10% Similarity=0.100 Sum_probs=80.8 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.|+.++.......++..++.++..++...+. .....+..|...+.+ ..+.++..++++|+.+.... T Consensus 397 ~~~~L~~~L~~~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~l~~L~~~l~~~~~~~~~~~a~~~L~~~~~~~ 466 (874) T 5A1V_E 397 LMNFLFTMLREEGGFEYKRAIVDCIISIIEENSE----------SKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKT 466 (874) T ss_dssp HHHHHHHHHHHHSSSSHHHHHHHHHHHHTTTTHH----------HHHHHHHHHHTSCSSSSCHHHHHHHHHHHHHHCCSS T ss_pred HHHHHHHHHhhcCCchhHHHHHHHHHHHHHHCHH----------HHHHHHHHHHHHHHhcCCHHHHHHHHHHhcccccCC Confidence 4555666665222233566677777776653221 112345556666553 34566777777777665431 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..++.+|..+....+. ....++..|..++.+. +..++..|.. T Consensus 467 ~~----~~~~l~~l~~~l~~------~~~~vr~~al~aL~~l~~~~~~-----~~~~i~~~L~~~l~d~-~~~vR~~A~~ 530 (874) T 5A1V_E 467 NN----PSKYIRFIYNRVVL------EHEEVRAGAVSALAKFGAQNEE-----MLPSILVLLKRCVMDD-DNEVRDRATF 530 (874) T ss_dssp SC----HHHHHHHHHHHHHT------SCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHHHHSTTTSS-SSHHHHHHHH T ss_pred CC----HHHHHHHHHHhhcc------CCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHHHHHHccCC-CHHHHHHHHH Confidence 11 01244555555554 3567888888888888764221 1123455555666555 7788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 531 ~l~~l~~~ 538 (874) T 5A1V_E 531 YLNVLEQK 538 (874) T ss_dssp HHHHHHTS T ss_pred HHHHHHHh Confidence 88876654 No 309 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=89.57 E-value=0.018 Score=63.83 Aligned_cols=141 Identities=10% Similarity=0.100 Sum_probs=80.8 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.|+.++.......++..++.++..++...+. .....+..|...+.+ ..+.++..++++|+.+.... T Consensus 397 ~~~~L~~~L~~~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~l~~L~~~l~~~~~~~~~~~a~~~L~~~~~~~ 466 (874) T 5NZR_G 397 LMNFLFTMLREEGGFEYKRAIVDCIISIIEENSE----------SKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKT 466 (874) T ss_pred HHHHHHHHHhhcCCchhHHHHHHHHHHHHHHCHH----------HHHHHHHHHHHHHHhcCCHHHHHHHHHHhcccccCC Confidence 4555666665222233566677777776653221 112345556666553 34566777777777665431 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..++.+|..+....+. ....++..|..++.+. +..++..|.. T Consensus 467 ~~----~~~~l~~l~~~l~~------~~~~vr~~al~aL~~l~~~~~~-----~~~~i~~~L~~~l~d~-~~~vR~~A~~ 530 (874) T 5NZR_G 467 NN----PSKYIRFIYNRVVL------EHEEVRAGAVSALAKFGAQNEE-----MLPSILVLLKRCVMDD-DNEVRDRATF 530 (874) T ss_pred CC----HHHHHHHHHHhhcc------CCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHHHHHHccCC-CHHHHHHHHH Confidence 11 01244555555554 3567888888888888764221 1123455555666555 7788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 531 ~l~~l~~~ 538 (874) T 5NZR_G 531 YLNVLEQK 538 (874) T ss_pred HHHHHHHh Confidence 88876654 No 310 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=89.50 E-value=0.018 Score=64.23 Aligned_cols=98 Identities=19% Similarity=0.075 Sum_probs=57.2 Template_Neff=11.000 Q NP_000290.2 250 AVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQN 329 (747) Q Consensus 250 Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~ 329 (747) ++.++.+.+...+..+...+..+....... ...++..+...+.+.++.++..++.++..+.... .... T Consensus 79 l~~ll~s~~~~~r~~~~~~l~~l~~~~~~~-----~~~ii~~l~~~l~~~~~~vr~~Al~~l~~~~~~~-------~~~~ 146 (939) T 6OWT_A 79 AVNLLSSNRYTEKQIGYLFISVLVNSNSEL-----IRLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------MAEA 146 (939) T ss_pred HHHHhcCCCHHHHHHHHHHHHHHccCChHH-----HHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHH-------HHHH Confidence 334455555566666666666655432211 1134455556666667778888888887765321 1123 Q NP_000290.2 330 GIREAVSLL--RRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 330 IL~~Ll~lL--~ss~d~eVr~~AL~aLsnLas~ 360 (747) ++..+...+ . +.++.++..++.++..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vR~~a~~~L~~l~~~ 178 (939) T 6OWT_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRT 178 (939) T ss_pred HHHHHHHHHcCC-CCCHHHHHHHHHHHHHHHHH Confidence 444555555 4 45677888888888887763 No 311 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=89.34 E-value=0.021 Score=68.25 Aligned_cols=151 Identities=13% Similarity=0.081 Sum_probs=101.4 Template_Neff=9.500 Q NP_000290.2 548 AI-RTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I-~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++ +.|+.++. + .+..++..++..|..+....+. .. ....+++.|...|.+.++.++..++.+|..++.. T Consensus 424 ~~~p~l~~ll~-~~~d~~~R~~al~~L~~~~~~~~~-------~~-~~~~i~p~l~~~l~d~~~~vr~~a~~~l~~l~~~ 494 (1454) T 5KC2_B 424 LFISYLSHSIR-SIVSTATKLKNLELLAVFAQFVSD-------EN-KIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTS 494 (1454) T ss_pred HhHHHHHHHhc-CCCCHHHHHHHHHHHHHHhhhCCH-------HH-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 56 88999998 5 6777888888888887763221 11 2235688888888888999999999999999821 Q NP_000290.2 626 ----PLL-HRVMGNQVFPEVTRLL---TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQY------------------ 679 (747) Q Consensus 626 ----~e~-~~ll~~giI~~Ll~LL---~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~L------------------ 679 (747) +.. ...+..++++.|..++ .+ .+..++..|+.+|..|+.........+ T Consensus 495 ~~~~~~~~~~~~~~~~l~~L~~ll~~~~d------~~~~vR~~a~~~l~~la~~~~~~~~~~~~~~~~~~~~~~~~~i~~ 568 (1454) T 5KC2_B 495 VRKLNQLNENIFVDYLLPRLKRLLISNRQ------NTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIME 568 (1454) T ss_pred hhcCHHHHHHHHHcCcHHHHHHHHcCCCC------CcHHHHHHHHHHHHHHhcCCCCcceEEhhHHhhhHHHHHHHHHHH Confidence 111 2234456778888888 65 367888999999998875422111111 Q NP_000290.2 680 ----FSSSMLNNIINLCRS----SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 680 ----ve~giL~~Ll~LL~s----~~d~eVr~aAL~aLsnL~~~ 714 (747) ...++++.|..++.. . ++.++..|+.+|..+... T Consensus 569 ~~~~~~~~~~~~l~~ll~~~l~d~-~~~vr~~a~~~l~~l~~~ 610 (1454) T 5KC2_B 569 SSTKYSAKLIQSVEDLTVSFLTDN-DTYVKMALLQNILPLCKF 610 (1454) T ss_pred HHHHHHcCHHHHHHHHHHhhcCCC-CHHHHHHHHHHHHHHhcC Confidence 123345556555554 4 677777787777777653 No 312 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=89.29 E-value=0.018 Score=60.92 Aligned_cols=154 Identities=10% Similarity=0.087 Sum_probs=87.1 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... . .... ....+++.+...+.+.++.++..++.++..++.... T Consensus 367 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 440 (876) T 2P8Q_A 367 VLPFIKEHIK-NPDWRYRDAAVMAFGCILEGPEP---S-QLKP-LVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440 (876) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHTSSSSCH---H-HHHH-HHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhCCCh---h-hcHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHCc Confidence 3555666666 46677888888888888764221 0 0111 123456677777777778899999999999887521 Q NP_000290.2 628 LH---RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK----------QYFS---SSMLNNIINL 691 (747) Q Consensus 628 ~~---~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~----------~Lve---~giL~~Ll~L 691 (747) .. ......+++.+...+.+ ++.++..++.++..++........ ..+. ..++..+... T Consensus 441 ~~~~~~~~~~~~~~~l~~~l~~-------~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 513 (876) T 2P8Q_A 441 EAAINDVYLAPLLQCLIEGLSA-------EPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLET 513 (876) T ss_dssp GGTSSTTTHHHHHHHHHHHTTS-------CHHHHHHHHHHHHHHHHHHHHHHTSSSSSSSCSCCTTGGGHHHHHHHHHHH T ss_pred HHhccchhHHHHHHHHHHHccC-------CHHHHHHHHHHHHHHHHHHHHHhccCCCCCCcchhhccHhHHHHHHHHHHH Confidence 10 11112345555555543 356777888888887754221100 0000 1234444444 Q NP_000290.2 692 CRS--SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 692 L~s--~~d~eVr~aAL~aLsnL~~~ 714 (747) +.. ..+..++..++.++..+... T Consensus 514 l~~~~~~~~~~r~~~~~~l~~l~~~ 538 (876) T 2P8Q_A 514 TDRPDGHQNNLRSSAYESLMEIVKN 538 (876) T ss_dssp TTCTTTTGGGHHHHHHHHHHHHHHS T ss_pred hcCCCCCcchHHHHHHHHHHHHHHh Confidence 431 11456777777777776643 No 313 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=89.10 E-value=0.019 Score=59.41 Aligned_cols=115 Identities=18% Similarity=0.151 Sum_probs=67.9 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQD--EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS--PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 245 ~iL~~Ll~lL~ssd--~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s--~d~eVr~~AL~aLs~La~~~~~ 320 (747) .+++.+...+.+.+ ..++..++.++..++...+..........+++.+...+.+ .++.++..++.++..++..... T Consensus 3 ~l~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~~~~~~ 82 (762) T 2QNA_A 3 ELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKA 82 (762) T ss_pred chHHHHHHHhcCCCCCHHHHHHHHHHHHHHHHhCCHhhcHHHHHhHHHHHHHHhcCCCCCHHHHHHHHHHHHHHHhcCCc Confidence 34555666666555 6788888888888775432211111112345666666653 3577888888888888754332 Q NP_000290.2 321 NKL-ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 321 ~~~-~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ... ......+++.+...+. +.++.++..++.++..++.. T Consensus 83 ~~~~~~~~~~i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 122 (762) T 2QNA_A 83 NFDKESERHFIMQVVCEATQ-CPDTRVRVAALQNLVKIMSL 122 (762) T ss_pred cCCcchhHHhHHHHHHHHhC-CCCHHHHHHHHHHHHHHHHh Confidence 111 0111234555555665 45677888888888887763 No 314 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=89.10 E-value=0.019 Score=55.65 Aligned_cols=154 Identities=11% Similarity=0.066 Sum_probs=94.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..+...... . .... ....+++.+...+.+.+ ..++..++.++..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (462) T 1IBR_B 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (462) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCG---G-GTGG-GHHHHHHHHHHHHSTTCCCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCCchHHHHHHHHHHHHHhhcCCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 5666777776 344 67788888888888764221 0 0001 12456777788887766 889999999999887 Q NP_000290.2 624 RHPLL-H--RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~-~--~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .++.++..++.+|..+...............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 275 (462) T 1IBR_B 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (462) T ss_dssp TTTHHHHTSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHCGGGCTTTTTTTHHHHHHHHHHCS-SHHH T ss_pred HHHHHhCCCHHHHHHHHHHHhHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHHhcC-CHHH Confidence 65211 0 11222233334444433 3567888889999888764333222222222366667777665 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (462) T 1IBR_B 276 ALQGIEFWSNVCDE 289 (462) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88898888888764 No 315 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=88.89 E-value=0.021 Score=60.61 Aligned_cols=154 Identities=10% Similarity=0.084 Sum_probs=87.2 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++.... T Consensus 367 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 440 (876) T 1QGR_A 367 VLPFIKEHIK-NPDWRYRDAAVMAFGCILEGPEP---S-QLKP-LVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440 (876) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCH---H-hcHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhCC Confidence 3455556666 36677888888888888764221 0 0111 123456677777777788899999999999887521 Q NP_000290.2 628 L--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK----------QYFS---SSMLNNIINL 691 (747) Q Consensus 628 ~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~----------~Lve---~giL~~Ll~L 691 (747) . . ......+++.+...+.+ ++.++..++.++..++........ ..+. ..++..+... T Consensus 441 ~~~~~~~~~~~~~~~l~~~l~~-------~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 513 (876) T 1QGR_A 441 EAAINDVYLAPLLQCLIEGLSA-------EPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLET 513 (876) T ss_pred hhhcCCchHHHHHHHHHHHhcC-------CHHHHHHHHHHHHHHHHHhhhccCCCCCCCCCcchhhhhhHHHHHHHHHHH Confidence 1 0 11112345555555543 356777888888887754221100 0000 1234444444 Q NP_000290.2 692 CRS--SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 692 L~s--~~d~eVr~aAL~aLsnL~~~ 714 (747) +.. ..+..++..++.++..++.. T Consensus 514 l~~~~~~~~~~r~~~~~~l~~l~~~ 538 (876) T 1QGR_A 514 TDRPDGHQNNLRSSAYESLMEIVKN 538 (876) T ss_pred hcCCCCCCHHHHHHHHHHHHHHHHc Confidence 431 11456777788877777643 No 316 >2DB0_A 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=88.88 E-value=0.021 Score=50.55 Aligned_cols=141 Identities=13% Similarity=0.132 Sum_probs=92.6 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+...... . ....++.+...+.+.+..++..++.++..+..... T Consensus 108 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~ 176 (253) T 2DB0_A 108 MIPVLFANYR-IGDEKTKINVSYALEEIAKANPM--------L--MASIVRDFMSMLSSKNREDKLTALNFIEAMGENSF 176 (253) T ss_dssp HHHHHHHHSC-CCSHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHTSCSSHHHHHHHHHHHHTCCTTTH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcH Confidence 4566677776 46778888888888887653211 1 13456667777777778888888888887654311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . .....++.+...+.+ .++.++..++.+|..+....+ .....++.+...+.+. ++.++..++.+ T Consensus 177 ~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~------~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 240 (253) T 2DB0_A 177 K---YVNPFLPRIINLLHD------GDEIVRASAVEALVHLATLND------KLRKVVIKRLEELNDT-SSLVNKTVKEG 240 (253) T ss_dssp H---HHGGGHHHHHGGGGC------SSHHHHHHHHHHHHHHHTSCH------HHHHHHHHHHHHCCCS-CHHHHHHHHHH T ss_pred H---hHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCH------HHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 0 011345556666665 367888899999998875322 1123466666667665 67889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 241 l~~l~~~~ 248 (253) T 2DB0_A 241 ISRLLLLE 248 (253) T ss_dssp HHHHHHC- T ss_pred HHHHHHHh Confidence 98887644 No 317 >2DB0_B 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=88.88 E-value=0.021 Score=50.55 Aligned_cols=141 Identities=13% Similarity=0.132 Sum_probs=93.1 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+...... . ....++.+...+.+.+..++..++.++..+..... T Consensus 108 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~ 176 (253) T 2DB0_B 108 MIPVLFANYR-IGDEKTKINVSYALEEIAKANPM--------L--MASIVRDFMSMLSSKNREDKLTALNFIEAMGENSF 176 (253) T ss_dssp HHHHHTTTCC-CCSHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHGGGGCSSHHHHHHHHHHHTTCCTTTH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcH Confidence 4566677776 46778888888888887653211 1 13456667777777778888888888887654311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . .....++.+...+.+ .++.++..++.+|..+....+ .....++.+...+.+. ++.++..++.+ T Consensus 177 ~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~------~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 240 (253) T 2DB0_B 177 K---YVNPFLPRIINLLHD------GDEIVRASAVEALVHLATLND------KLRKVVIKRLEELNDT-SSLVNKTVKEG 240 (253) T ss_dssp H---HHGGGHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHCH------HHHHHHHHHHHTCCCS-CHHHHHHHHHH T ss_pred H---hHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCH------HHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 0 011345556666665 367888899999998875322 1123466666667665 67889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 241 l~~l~~~~ 248 (253) T 2DB0_B 241 ISRLLLLE 248 (253) T ss_dssp HHHHHTTC T ss_pred HHHHHHHh Confidence 98887644 No 318 >4K92_B CLIP-associating protein 1; HEAT-Repeat TOG domain, Regulator of; HET: MSE; 2.005A {Homo sapiens} Probab=88.82 E-value=0.022 Score=52.46 Aligned_cols=148 Identities=16% Similarity=0.091 Sum_probs=93.3 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. +.+..++..++.+|..++..... .... .-..+++.|+..+.+.+..++..++.+|..++.... T Consensus 90 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 162 (273) T 4K92_B 90 LDGAFKLSAK-DLRSQVVREACITLGHLSSVLGN-----KFDH-GAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH 162 (273) T ss_dssp THHHHHHHHT-CSCHHHHHHHHHHHHHHHHHHGG-----GGHH-HHHHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHH-cHHHHHHHHHHHHHHHHHHHHHH-----HhHH-HHHHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC Confidence 4556666666 46778888899988888764221 0111 123466677777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..++...........-..+++.+...+.+. +..++..++.+ T Consensus 163 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~vr~~a~~~ 230 (273) T 4K92_B 163 I-----PRLIPVITSNCTS------KSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDA-DSEARIEARKC 230 (273) T ss_dssp C-----TTHHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHSCHHHHTTCHHHHHHHHHHHHTCS-SHHHHHHHHHH T ss_pred C-----chHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcCchhHHHHHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1234455555554 3577888888888888764322100011123566666777666 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (273) T 4K92_B 231 YWGFHSH 237 (273) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887754 No 319 >6MQ7_B CLIP-associating protein 1; microtubule binding protein, STRUCTURAL PROTEIN; 1.78A {Homo sapiens} Probab=88.82 E-value=0.022 Score=52.46 Aligned_cols=148 Identities=16% Similarity=0.091 Sum_probs=93.3 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. +.+..++..++.+|..++..... .... .-..+++.|+..+.+.+..++..++.+|..++.... T Consensus 90 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 162 (273) T 6MQ7_B 90 LDGAFKLSAK-DLRSQVVREACITLGHLSSVLGN-----KFDH-GAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH 162 (273) T ss_dssp THHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHGG-----GGHH-HHHHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHH-cHHHHHHHHHHHHHHHHHHHHHH-----HhHH-HHHHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC Confidence 4556666666 46778888899988888764221 0111 123466677777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..++...........-..+++.+...+.+. +..++..++.+ T Consensus 163 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~vr~~a~~~ 230 (273) T 6MQ7_B 163 I-----PRLIPVITSNCTS------KSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDA-DSEARIEARKC 230 (273) T ss_dssp C-----GGGHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHSCGGGTTTCHHHHHHHHHHHHTCS-SHHHHHHHHHH T ss_pred C-----chHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcCchhHHHHHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1234455555554 3577888888888888764322100011123566666777666 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (273) T 6MQ7_B 231 YWGFHSH 237 (273) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887754 No 320 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=88.73 E-value=0.022 Score=55.37 Aligned_cols=154 Identities=12% Similarity=0.095 Sum_probs=94.5 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|+..+. +.+ +.++..++.+|..+...... .........+++.+...+.+.+ +.++..++.++..+. T Consensus 135 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~ 208 (460) T 1GCJ_B 135 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP-----EQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 208 (460) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCH-----HHHGGGHHHHHHHHHHHHCTTCSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCCcHHHHHHHHHHHHHHhhhCCH-----HHhHHHHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 4566777776 344 67788888888888764221 0000112356777777787665 889999999999887 Q NP_000290.2 624 RHPLL--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .+..++..++.+|..+....+......+...+++.+..++.+. ++.+ T Consensus 209 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 281 (460) T 1GCJ_B 209 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 281 (460) T ss_dssp TTCHHHHTSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHTTCGGGGGGTCCCCCHHHHHHHHTCS-SHHH T ss_pred HHHHHhCCCHHHHHHHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhhCC-CHHH Confidence 65111 1 11112233344444443 3567888889999888765333222222222366677777665 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 282 ~~~a~~~l~~l~~~ 295 (460) T 1GCJ_B 282 ALQGIEFWSNVCDE 295 (460) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88899988888764 No 321 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=88.68 E-value=0.022 Score=54.84 Aligned_cols=154 Identities=11% Similarity=0.067 Sum_probs=94.0 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.+ +.++..++.+|..+...... . .... ....+++.+..++.+.+ ..++..++.++..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (442) T 1F59_B 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (442) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCG---G-GGGG-GHHHHHHHHHHTTSTTCCCHHHHHHHHHHHHHHS T ss_pred HHHHHHHHhh-CCCCcHHHHHHHHHHHHHHHhhCCH---H-HhHH-HHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHH Confidence 5666777776 344 67788888888887754221 0 0001 12456777777777766 889999999999987 Q NP_000290.2 624 RHPLL--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .+..++..++.+|..++...+..........+++.+..++.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 275 (442) T 1F59_B 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (442) T ss_dssp TTCHHHHHSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHTGGGGGGTCCCCCHHHHHHHHHSS-CHHH T ss_pred HHHHHcCCCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCC-cHHH Confidence 65211 1 01112233333333333 3567888889999888765333322222222356666777655 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (442) T 1F59_B 276 ALQGIEFWSNVCDE 289 (442) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhH Confidence 88899988888764 No 322 >1UKL_A Importin beta-1 subunit/Sterol regulatory element; Transcription factor, Nuclear transport factor; HET: MSE; 3.0A {Mus musculus} SCOP: a.118.1.1 Probab=88.63 E-value=0.022 Score=60.17 Aligned_cols=113 Identities=10% Similarity=0.112 Sum_probs=64.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTN-KLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~-~~~ 324 (747) +++.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++...... ... T Consensus 367 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 446 (876) T 1UKL_A 367 VLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAIND 446 (876) T ss_dssp HHHHHHHHSSCSSHHHHHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHSCT T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHhCCChhhhHHHHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHHChHHhcCc Confidence 3344444455566778888888888876543211111112345566666666667788888888888887543321 001 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. . ++.++..++.++..++.. T Consensus 447 ~~~~~~~~~l~~~l~-~-~~~~~~~~~~~l~~l~~~ 480 (876) T 1UKL_A 447 VYLAPLLQCLIEGLS-A-EPRVASNVCWAFSSLAEA 480 (876) T ss_dssp TTHHHHHHHHHHHTT-S-CHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHhc-C-ChhHHHHHHHHHHHHHHH Confidence 111234555555554 3 456677777777776653 No 323 >1U6G_C Cullin homolog 1, RING-box protein; cullin repeat, heat repeat, ring; 3.1A {Homo sapiens} SCOP: a.118.1.2 Probab=88.22 E-value=0.025 Score=62.86 Aligned_cols=146 Identities=12% Similarity=0.093 Sum_probs=89.7 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. . ++.++..++.++..+....+. . .... .-..+++.+...+.+.++.++..++.+|+.+..... T Consensus 891 ~~~~l~~~l~-~-~~~~r~~~~~~l~~i~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 963 (1230) T 1U6G_C 891 YLPFVLQEIT-S-QPKRQYLLLHSLKEIISSASV---V-GLKP-YVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDP 963 (1230) T ss_dssp HHHHHHHHHH-S-CGGGHHHHHHHHHHHHHSSCS---T-TTHH-HHHHHHHHHTTCCCCSSTTHHHHHHHHHHHHHHSSG T ss_pred HHHHHHHHHc-c-CchHHHHHHHHHHHHHhcccc---c-ccHH-hHHHHHHHHHHHcCCCChhHHHHHHHHHHHHHccCH Confidence 4555555554 2 455666777777777653221 0 0001 113466677777777788899999999988876421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...++.+...+.+ .+..++..++.+|..+....+........ ..++.++..+.+. ++.++..++.+ T Consensus 964 ------~~~~~~l~~~l~~------~~~~~r~~~~~~l~~~~~~~~~~~~~~~~-~~~~~l~~~l~d~-~~~vr~~a~~~ 1029 (1230) T 1U6G_C 964 ------ETLLPRLKGYLIS------GSSYARSSVVTAVKFTISDHPQPIDPLLK-NCIGDFLKTLEDP-DLNVRRVALVT 1029 (1230) T ss_dssp ------GGTHHHHTTTSSS------SCHHHHHHHHHHTGGGCCSSCCTHHHHHH-HHSTTTHHHHSSS-STHHHHHHHHH T ss_pred ------HhHHHHHHHHhhC------CCHHHHHHHHHHHHHHHcCCCCCccHHHH-HHHHHHHHHcCCC-CHHHHHHHHHH Confidence 1234555666654 25667788888888877643221111222 4567777777766 77888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 1030 l~~l~~~ 1036 (1230) T 1U6G_C 1030 FNSAAHN 1036 (1230) T ss_dssp HHHHHHH T ss_pred HHHHHhc Confidence 8888754 No 324 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=88.09 E-value=0.031 Score=59.08 Aligned_cols=135 Identities=14% Similarity=0.062 Sum_probs=91.1 Template_Neff=8.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE---------SAKQQVYQLGGICKLVDLLRS------PNQNVQQAAAGA 310 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~---------~~~~~li~~~IL~~Ll~lL~s------~d~eVr~~AL~a 310 (747) +++.|+.++.+.+..+...++.+|..++.... .....+...++++.++..+.. .+......++.+ T Consensus 69 ~i~~Lv~LL~~~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l~~~g~l~~Lv~~L~~~~e~~~~d~~~~~~al~~ 148 (490) T 4MFU_A 69 AVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAI 148 (490) T ss_dssp HHHHHHHHTSCSSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHHHHTTHHHHHHHHHHHCCTTCHHHHHHHHHHHHH T ss_pred hHHHHHHHhCCCCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHHHhCCHHHHHHHHHHhccccccchHHHHHHHHHH Confidence 45566677776667778888888888876432 122333445677777777764 456677888899 Q NP_000290.2 311 LRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 311 Ls~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) |.+++...+.....+...++++.|+..+. .. ...++..+..+|..++.. ......+.. ++++.|+.+|.. T Consensus 149 L~nL~~~~~~~~~~i~~~~~l~~Ll~~L~-~~~~~~~~k~~a~~~L~~L~~~~~~~~~~l~~~g~i~~Ll~lL~~ 222 (490) T 4MFU_A 149 VENMAEFRPEMCTEGAQQGLLQWLLKRLK-AKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSV 222 (490) T ss_dssp HHHHHHHSTTHHHHHCCCCCHHHHHHHHH-CCSCCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHT T ss_pred HHHHhccCHHHHHHHHHCCHHHHHHHHHH-cCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHh Confidence 99888654333333444567888888886 33 467788899999999875 333444444 788888888863 No 325 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=87.58 E-value=0.03 Score=55.48 Aligned_cols=141 Identities=14% Similarity=0.110 Sum_probs=94.1 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.+..++..++.++..+....+. . ...+++.+...+.+.++.++..++.++..+..... T Consensus 37 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 105 (570) T 6CRI_I 37 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKI 105 (570) T ss_dssp GHHHHHHTCS-CSCHHHHHHHHHHHHHTTTTSTT--------G--GGTTHHHHHHHTSSSCHHHHHHHHHHHHHCCCTTT T ss_pred hHHHHHHhcc-CCCHHHHHHHHHHHHHHHccCHh--------H--HHHHHHHHHHHcCCCCHHHHHHHHHHHccCChhHH Confidence 4555666676 46677888888888887754221 1 12345666777777788889999998888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+... .....++.+...+.+. ++.++..++.+ T Consensus 106 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~---~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 170 (570) T 6CRI_I 106 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQLV---EDQGFLDTLKDLISDS-NPMVVANAVAA 170 (570) T ss_dssp -----TTTSHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHCHHHH---HHHTHHHHHHHHHTSS-SHHHHHHHHHH T ss_pred -----HHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHHhChhhh---hccchHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666665 367888999999998876433221 1134567777777766 77888889998 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 171 l~~~~~~ 177 (570) T 6CRI_I 171 LSEIAES 177 (570) T ss_dssp HHHHHHH T ss_pred HHHHHhh Confidence 8888765 No 326 >3QML_D 78 kDa glucose-regulated protein homolog; Armadillo like repeats, CHAPERONE-PROTEIN TRANSPORT; HET: PO4; 2.31A {Saccharomyces cerevisiae} Probab=87.49 E-value=0.038 Score=55.35 Aligned_cols=165 Identities=6% Similarity=-0.069 Sum_probs=100.7 Template_Neff=7.900 Q NP_000290.2 534 ETNPKGSGWLYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK--GLPQIA---RLLQ-- 605 (747) Q Consensus 534 ~~ni~~~~~lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g--iI~~Ll---~LL~-- 605 (747) .+++.....+++.| ++.|+.++... ....++..|+++|+..+.+++. ....+.+.+ +++.|+ ..|. T Consensus 56 ~hdid~a~~~~~~g-~~~L~~~l~~~~~~~~ir~~Aa~iigsa~qNNP~-----aq~~~~~~~~~~l~~Ll~~~~~L~~~ 129 (315) T 3QML_D 56 AHDYKHGYKIITHE-FALLANLSLNENLPLTLRELSTRVITSCLRNNPP-----VVEFINESFPNFKSKIMAALSNLNDS 129 (315) T ss_dssp HTSHHHHHHHHHHH-HHHHHHHHHCTTSCHHHHHHHHHHHHHHHTTCTT-----HHHHHHHHCTTHHHHHHHHHHHHHCC T ss_pred HccHHHHHHHHHch-HHHHHHHHhCCCCCHHHHHHHHHHHHHHHhhCHH-----HHHHHHHHCccHHHHHHHHHHhhccC Confidence 34556666677888 88888888721 5678999999999999988764 344445555 677777 4443 Q NP_000290.2 606 --SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA------ 676 (747) Q Consensus 606 --s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~------ 676 (747) ..++.++..++.+|+.|+.+... ..+ ++..|..++... ..+..++..++.++..+........ T Consensus 130 ~~~~~~~v~~k~L~aLS~Lir~~~~~~~F----G~~~L~~~~~~~----~~~~~~~~K~l~ll~dl~~~~~~~~~~~~~~ 201 (315) T 3QML_D 130 NHRSSNILIKRYLSILNELPVTSEDLPIY----STVVLQNVYERN----NKDKQLQIKVLELISKILKADMYENDDTNLI 201 (315) T ss_dssp ---CTHHHHHHHHHHHHHSCCCGGGGGGS----CHHHHHHHHHTT----TTCHHHHHHHHHHHHHHHTTTC------CHH T ss_pred CCcCCHHHHHHHHHHHHhhcCCCccHhhh----cHHHHHHHHHhC----CCCHHHHHHHHHHHHHHHHhccccCCCcchH Confidence 35677888999999999987322 222 456666666431 0135677788888888775432211 Q NP_000290.2 677 --------KQYFSSSMLNNIINLCRSS-ASPKAAEAARLLLSDMW 712 (747) Q Consensus 677 --------~~Lve~giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~ 712 (747) ......+.+..+...+... .+....+.++.+|..|. T Consensus 202 ~~~~~~~~~~~~~~~~c~~l~~~L~~~~~d~~~~ek~l~~L~~L~ 246 (315) T 3QML_D 202 LFKRNAENWSSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLK 246 (315) T ss_dssp HHHHHHHTTCSCCHHHHHHHHHHTTCTTSCHHHHHHHHHHHHHHH T ss_pred HhHhhccccchhHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHH Confidence 1111133445555555421 13455566666666554 No 327 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=87.43 E-value=0.036 Score=65.15 Aligned_cols=154 Identities=8% Similarity=0.029 Sum_probs=84.9 Template_Neff=9.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++..++..+. +.+..++..++.+|..++..... .. .... ....+++.+...+... ...+..++.+|..++... T Consensus 848 ~il~~l~~~l~-d~~~~~r~~a~~~L~~l~~~~~~--~~-~~~~-~~~~li~~ll~~l~~~-~~~r~~al~~L~~l~~~~ 921 (1304) T 5IFE_C 848 EIISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA--AD-IDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNAL 921 (1304) T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcCh--hh-hHHH-HHHHHHHHHHHHhcCC-HHHHHHHHHHHHHHHHhC Confidence 34556666666 35556777788888777653211 00 0001 1123444455444432 356677788887777652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . . ..++ ..++..+...+.+ .+..++..++.+|..++..............++..|...+.+. ++.++..+ T Consensus 922 ~~~~~~~l-~~l~~~L~~~L~~------~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~-~~~vr~~a 993 (1304) T 5IFE_C 922 GKRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSI 993 (1304) T ss_pred HHHhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCC-CHHHHHHH Confidence 1 1 1111 2355556666655 3678888999999998764222111111123456666666654 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 994 l~aL~~l~~~ 1003 (1304) T 5IFE_C 994 LGALKAIVNV 1003 (1304) T ss_pred HHHHHHHHHh Confidence 7777776644 No 328 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=87.43 E-value=0.036 Score=65.15 Aligned_cols=154 Identities=8% Similarity=0.029 Sum_probs=84.9 Template_Neff=9.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++..++..+. +.+..++..++.+|..++..... .. .... ....+++.+...+... ...+..++.+|..++... T Consensus 848 ~il~~l~~~l~-d~~~~~r~~a~~~L~~l~~~~~~--~~-~~~~-~~~~li~~ll~~l~~~-~~~r~~al~~L~~l~~~~ 921 (1304) T 6AHD_1 848 EIISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA--AD-IDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNAL 921 (1304) T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcCh--hh-hHHH-HHHHHHHHHHHHhcCC-HHHHHHHHHHHHHHHHhC Confidence 34556666666 35556777788888777653211 00 0001 1123444455444432 356677788887777652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . . ..++ ..++..+...+.+ .+..++..++.+|..++..............++..|...+.+. ++.++..+ T Consensus 922 ~~~~~~~l-~~l~~~L~~~L~~------~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~-~~~vr~~a 993 (1304) T 6AHD_1 922 GKRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSI 993 (1304) T ss_pred HHHhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCC-CHHHHHHH Confidence 1 1 1111 2355556666655 3678888999999998764222111111123456666666654 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 994 l~aL~~l~~~ 1003 (1304) T 6AHD_1 994 LGALKAIVNV 1003 (1304) T ss_pred HHHHHHHHHh Confidence 7777776644 No 329 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=87.43 E-value=0.031 Score=52.40 Aligned_cols=141 Identities=16% Similarity=0.154 Sum_probs=92.9 Template_Neff=12.800 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) ++.++..+. +.++.++..++.+|..+....+. .....++.+...+.+.+..++..++.+|..+...... T Consensus 190 ~~~l~~~l~-~~~~~~~~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~ 258 (373) T 5MU7_A 190 LGTVFEGIP-NAEELLQLVEIEFIRKDALHNPQ----------NKPRYLRLIFDLLEANTSTVVYEAASSLTALTNNPVA 258 (373) T ss_dssp HHHTGGGGG-GSCHHHHHHHHHHHHHHHHHCGG----------GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHCCCHHH T ss_pred HHHHHhcCC-ChhHHHHHHHHHHHHHHhccCcc----------cHHHHHHHHHHHHhcCCHHHHHHHHHHHHHcCCCHHH Confidence 455566666 35667777888888887653221 1234566777777777788888888888887743211 Q NP_000290.2 629 HRVMGNQVFPEVTRLLT-SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~-s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+. + .++.++..++.+|..+....+.. + ...++.+...+.+. ++.++..++.+ T Consensus 259 ---~-~~~~~~l~~~l~~~------~~~~vr~~a~~~l~~l~~~~~~~----~-~~~~~~l~~~l~~~-~~~vr~~a~~~ 322 (373) T 5MU7_A 259 ---V-KAAAGKFIELAIKE------ADNNVKLIVLDRVDQLRQKNEGI----L-DDLIMEILRVLSSP-DIDVRRKALEI 322 (373) T ss_dssp ---H-HHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHTTTT----T-GGGHHHHHHGGGSS-CHHHHHHHHHH T ss_pred ---H-HHHHHHHHHHHhhC------CChhHHHHHHHHHHHHHHhCHHH----H-HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 134556666665 4 36788889999999887643211 1 13566677777665 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) |..+..... T Consensus 323 l~~~~~~~~ 331 (373) T 5MU7_A 323 ALEMVSSKN 331 (373) T ss_dssp HHTTCCTTT T ss_pred HHHHhcCCC Confidence 998876544 No 330 >5VE8_B Kap123, Histone H3; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.7A {Kluyveromyces lactis} Probab=87.41 E-value=0.031 Score=61.14 Aligned_cols=154 Identities=11% Similarity=0.104 Sum_probs=81.3 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) ++.+...+. ..++.++..++.++..++..... ... ....+++.++..+ .+.++.++..++.++..++.. + T Consensus 868 ~~~l~~~~~-~~~~~~r~~~~~~l~~l~~~~~~------~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~ 939 (1116) T 5VE8_B 868 KPVILQLCQ-SKSKNKRSFAVGALSEIALGMRD------ENP-FIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSS 939 (1116) T ss_dssp HHHHHHHTT-CSCHHHHHHHHHHHHHHHHHHGG------GCT-THHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHcC-CCCHHHHHHHHHHHHHHHHhCCC------Cch-hHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhCC Confidence 333444443 24556677777777777653221 111 1134555555553 345678889999999888865 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGN----------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~----------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) .. ...+ ..+++.|...+...... ......++..++.+|+.+....+... ....+++.++..+... T Consensus 940 ~~~~~~~-~~il~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~---~~~~~l~~~~~~l~~~ 1015 (1116) T 5VE8_B 940 FDVSAIY-SPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLV---PLEHTIPALLSHLPFN 1015 (1116) T ss_dssp SCCHHHH-HHHHHHHHHHHHHHHHHC-----CHHHHHHHHHHHHHHHHHHHHHHHHCGGGS---CHHHHHHHHHTTCSCS T ss_pred cchhhhH-HHHHHHHHHHhcchhHhccCCCCchhhHHHHHHHHHHHHHHHHHHHHHCcccC---CHHHHHHHHHhcCCCC Confidence 11 1111 23555566555431000 00245667788888888876533211 1123455555555322 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~ 714 (747) .+...+..++.+|..+... T Consensus 1016 ~~~~~~~~~~~~l~~l~~~ 1034 (1116) T 5VE8_B 1016 TAFEEYDPIFKLFLKLFQE 1034 (1116) T ss_dssp SCGGGHHHHHHHHHHHHHT T ss_pred CchhhhHHHHHHHHHHHHh Confidence 1455666677777766543 No 331 >2IX8_A ELONGATION FACTOR 3A; NUCLEOTIDE-BINDING, PROTEIN BIOSYNTHESIS, PHOSPHORYLATION, ELONGATION; 6.0A {SACCHAROMYCES CEREVISIAE} Probab=87.28 E-value=0.034 Score=61.28 Aligned_cols=150 Identities=9% Similarity=0.007 Sum_probs=99.4 Template_Neff=11.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...+. +.++.++..++.+|..+...... .... ....+++.|...+.+.++.++..|+.+|..++... T Consensus 48 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 120 (976) T 2IX8_A 48 HFFGELAKGIK-DKKTAANAMQAVAHIANQSNLSP-----SVEP-YIVQLVPAICTNAGNKDKEIQSVASETLISIVNAV 120 (976) T ss_dssp HHHHHHHHHHT-STTTHHHHHHHHHHHSCTTTCCT-----TTHH-HHHTTHHHHHHHTTCSSHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CHHHHHHHHHHHHHHHHHhccCc-----ccHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhc Confidence 45677777777 46677888888888888753221 0111 12356777777888888889999999999887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .... ...+++.|...+ .+ .++.++..++.+|..++...+....... ..+++.+..++.+. +..++..++ T Consensus 121 ~~~~--~~~~l~~l~~~l~~~------~~~~vr~~al~~L~~l~~~~~~~~~~~~-~~~~~~l~~~l~d~-~~~vr~~a~ 190 (976) T 2IX8_A 121 NPVA--IKALLPHLTNAIVET------NKWQEKIAILAAFSAMVDAAKDQVALRM-PELIPVLSETMWDT-KKEVKAAAT 190 (976) T ss_dssp CGGG--HHHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHSHHHHHHHH-HHHHHHHHHHTTCS-CHHHHHHHH T ss_pred CHHH--HHHHHHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhHHhhc-hhHHHHHHHhhcCC-CHHHHHHHH Confidence 1111 123556666666 33 3567888899999988864322211111 24677777777766 788899999 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 191 ~~l~~l~~ 198 (976) T 2IX8_A 191 AAMTKATE 198 (976) T ss_dssp HHHHHHST T ss_pred HHHHHHHH Confidence 99888876 No 332 >3WOY_A CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; 2.1A {Homo sapiens} Probab=87.26 E-value=0.034 Score=50.12 Aligned_cols=147 Identities=14% Similarity=0.116 Sum_probs=92.3 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.+..++..++.++..++..... ....+ -..+++.+...+.+....++..+..++..++.... T Consensus 78 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~~-~~~l~~~l~~~l~~~~~~vr~~a~~~l~~i~~~~~ 150 (251) T 3WOY_A 78 LDGALKLSAK-DLRSQVVREACITVAHLSTVLGN-----KFDHG-AEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTH 150 (251) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHCc-----ccHHH-HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCC Confidence 4555666666 46678888899999888764321 01111 13456667777766677788888888888875421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . ..+++.+...+.+ .++.++..++.++..++...... .... -..+++.+...+.+. +..++..++. T Consensus 151 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~-~~~i~~~l~~~l~d~-~~~vr~~a~~ 217 (251) T 3WOY_A 151 V-----PRLIPLITSNCTS------KSVPVRRRSFEFLDLLLQEWQTHSLERH-AAVLVETIKKGIHDA-DAEARVEARK 217 (251) T ss_pred H-----hhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHCHHhhHHh-HHHHHHHHHHHhcCC-CHHHHHHHHH Confidence 1 1244455555554 35677888888888887542211 1111 123566677777766 7889999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 218 ~l~~l~~~ 225 (251) T 3WOY_A 218 TYMGLRNH 225 (251) T ss_pred HHHHHHHH Confidence 88887754 No 333 >5DN7_A Protein FAM179B; TOG domain, STRUCTURAL PROTEIN; 2.2A {Mus musculus} Probab=87.22 E-value=0.035 Score=51.97 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=94.2 Template_Neff=11.400 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..+..... T Consensus 67 l~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~l~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 139 (293) T 5DN7_A 67 FISLLYNLLD-DSNFKVVHGTLQVLHLLVIRLGE-----QVQQ-FLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVG 139 (293) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHGGGCCCHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHHH-----HHHH-HHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHHC Confidence 4555666666 46778888889888888764221 0111 113467777777777778888889998888875311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.++..+........ ..-..+++.+...+.+. +..++..++.+ T Consensus 140 ~-----~~~~~~l~~~l~~------~~~~vr~~al~~l~~l~~~~~~~~--~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 205 (293) T 5DN7_A 140 P-----QRVLSLLLENLKH------KHSRVREEVVNICICSLLTYPSED--FDLPKLSFDLAPALVDS-KRRVRQAALEA 205 (293) T ss_dssp H-----HHHHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHSCGGG--SCHHHHHHHHGGGGGCS-SHHHHHHHHHH T ss_pred H-----HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCCccc--CCHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1244555555554 367788888888888876432211 11124566677777766 78888889888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 206 l~~l~~~ 212 (293) T 5DN7_A 206 FAVLASS 212 (293) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887653 No 334 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=87.21 E-value=0.04 Score=59.57 Aligned_cols=135 Identities=14% Similarity=0.062 Sum_probs=91.1 Template_Neff=8.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE---------SAKQQVYQLGGICKLVDLLRS------PNQNVQQAAAGA 310 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~---------~~~~~li~~~IL~~Ll~lL~s------~d~eVr~~AL~a 310 (747) .++.|+.++.+.+..+...++.+|..+..... .....+...++++.|+..+.. .+...+..++.+ T Consensus 147 ~i~~Lv~LL~~~n~di~~~a~~~L~~Lt~~~~~~~~~~~~~~l~~~l~e~g~l~~Lv~~L~~l~e~~~~d~~~~~~al~i 226 (568) T 4HM9_A 147 AVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAI 226 (568) T ss_dssp HHHHHHHGGGCSSHHHHHHHHHHHHHHTCHHHHTTCHHHHHHHHHHHHHTTHHHHHHHHHTTCCTTSHHHHHHHHHHHHH T ss_pred hHHHHHHHhCCCCHHHHHHHHHHHHHHhCCccccCChhhHHHHHHHHHhCCHHHHHHHHHhcccccccchHHHHHHHHHH Confidence 45566677776667788888888888875432 112333445677777777765 455677888999 Q NP_000290.2 311 LRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 311 Ls~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) |.+++...+.....+...+++..|+.++. .. ....+..+..+|..|+.. ......+.. ++++.|+.+|.. T Consensus 227 L~nL~~~~~~~~~~i~~~g~l~~Ll~lL~-~~~~~~~~k~~AaeiL~~L~~~~~~~r~~l~~~g~I~~LL~lL~~ 300 (568) T 4HM9_A 227 VENMAEFRPEMCTEGAQQGLLQWLLKRLK-AKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSV 300 (568) T ss_dssp HHHHHHHCGGGHHHHCCCCCHHHHHHHHH-SSCCCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHGG T ss_pred HHHHhccCHHHHHHHHHCCHHHHHHHHHH-cCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHh Confidence 99888653332223344567888888886 33 456788899999999875 344444444 888989988864 No 335 >6S47_Bi 60S ribosomal protein L2-A, 60S; New1, ABCF, Ribosomal Protein, Recycling; HET: ATP; 3.28A {Saccharomyces cerevisiae} Probab=87.16 E-value=0.035 Score=61.24 Aligned_cols=155 Identities=12% Similarity=0.055 Sum_probs=101.1 Template_Neff=11.700 Q NP_000290.2 546 SDAIRTYLNLMGKS-KKDATLEACAGALQNLTASK-GLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s-~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .++++.|..++. + .++.++..++.+|..++... .. . ....+. ..+++.|...+.+.++.++..++.+|..++ T Consensus 42 ~~il~~l~~~l~-~~~~~~vr~~a~~~L~~l~~~~~~~---~-~~~~~~-~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~ 115 (972) T 6S47_Bi 42 WKIVDVLSKFIK-PKNPSLVRESAMLIISNIAQFFSGK---P-PQEAYL-LPFFNVALDCISDKENTVKRAAQHAIDSLL 115 (972) T ss_pred ccHHHHHHHHcC-CCCCHHHHHHHHHHHHHHHhcCCCh---h-hcHHHH-HHHHHHHHHHhCCCCHHHHHHHHHHHHHHH Confidence 346777777777 4 56778888999998887643 10 0 001111 236777778888778889999999999887 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ..... ......+++.|..++.+. .++.++..++.+|+.++..............+++.|+..+.+. ++.++.. T Consensus 116 ~~~~~-~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~i~~~~~~~~~~~~~~~~~~~l~~~l~d~-~~~vr~~ 188 (972) T 6S47_Bi 116 NCFPM-EALTCFVLPTILDYLSSG-----AKWQAKMAALSVVDRIREDSANDLLELTFKDAVPVLTDVATDF-KPELAKQ 188 (972) T ss_pred hcCCH-HhhHhchHHHHHHHcCCC-----CCHHHHHHHHHHHHHHHhhCCHHHHHHHHHHHHHHHHHHhcCC-CHHHHHH Confidence 65111 111113566677776652 1278889999999998554322211112234677777788766 7889999 Q NP_000290.2 704 ARLLLSDMWS 713 (747) Q Consensus 704 AL~aLsnL~~ 713 (747) ++.+|..+.. T Consensus 189 a~~~L~~l~~ 198 (972) T 6S47_Bi 189 GYKTLLDYVS 198 (972) T ss_pred HHHHHHHHHH Confidence 9999988775 No 336 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=87.12 E-value=0.034 Score=55.81 Aligned_cols=142 Identities=13% Similarity=0.105 Sum_probs=94.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. ++++.++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 50 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 118 (592) T 6QH5_B 50 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKI 118 (592) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHH--------H--HHHHHHHHHHHccCCCHHHHHHHHHHHHHHcchhh Confidence 4555666666 46677888888888887654221 1 13456667777778888899999999888765311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. ......++.+...+.+. ++.++..++.+ T Consensus 119 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~---~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 183 (592) T 6QH5_B 119 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQM---VEDQGFLDSLRDLIADS-NPMVVANAVAA 183 (592) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCchh---hcCccHHHHHHHHhCCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 12234567777777765 77888889888 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 184 l~~~~~~~ 191 (592) T 6QH5_B 184 LSEISESH 191 (592) T ss_pred HHHHHhcC Confidence 88887654 No 337 >5A1V_G ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=87.07 E-value=0.037 Score=61.89 Aligned_cols=105 Identities=19% Similarity=0.265 Sum_probs=67.3 Template_Neff=10.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|..++. +.++.++..|+.+|..+..... . ....+..++..+ .+.+..++..++.+|..+... T Consensus 259 ~~~~~L~~~l~-~~~~~vr~~a~~~L~~l~~~~~---------~--~~~~~~~l~~~l~~~~~~~vr~~al~~L~~l~~~ 326 (968) T 5A1V_G 259 RFIRCIYNLLQ-SSSPAVKYEAAGTLVTLSSAPT---------A--IKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEH 326 (968) T ss_dssp HHHHHHHHSCC-SSSCSSCCTTHHHHTGGGCSTH---------H--HHHHHHHHHHHHHCCCCCCTTCCCCSCSSSSCSC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHhCCCHH---------H--HHHHHHHHHHHHHhcCChHHHHHHHHHHHHHhhC Confidence 35666777777 4667788888888887765311 0 123455566666 566778888999999988753 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +.....+ ..+++.+...+.+ .+..++..++.+|..+.. T Consensus 327 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~al~~L~~l~~ 364 (968) T 5A1V_G 327 PAHERVL-QDLVMDILRVLST------PDLEVRKKTLQLALDLVS 364 (968) T ss_dssp CSSCSSC-SHHHHHHTSCSSS------SCHHHHHHHHHHHHHHSS T ss_pred cchHHHH-HHHHHHHHHHhCC------CCHHHHHHHHHHHHHHcC Confidence 2211111 2345556666655 356788888888888765 No 338 >3TJZ_B ADP-ribosylation factor 1, Coatomer subunit; protein trafficking, Golgi membrane, protein; HET: GNP; 2.9A {Saccharomyces cerevisiae} Probab=86.96 E-value=0.036 Score=52.53 Aligned_cols=16 Identities=25% Similarity=-0.029 Sum_probs=8.2 Template_Neff=12.100 Q NP_000290.2 697 SPKAAEAARLLLSDMW 712 (747) Q Consensus 697 d~eVr~aAL~aLsnL~ 712 (747) ++.++..++.+|..+. T Consensus 225 ~~~~~~~~~~~l~~~~ 240 (355) T 3TJZ_B 225 SPFAYCMMIRVASRQL 240 (355) T ss_pred CHHHHHHHHHHHHHhC Confidence 4445555555555544 No 339 >2IW3_B ELONGATION FACTOR 3A; ACETYLATION, ATP-BINDING, ELONGATION FACTOR, PROTEIN; HET: MSE, ADP, SO4; 2.4A {SACCHAROMYCES CEREVISIAE} Probab=86.93 E-value=0.037 Score=61.15 Aligned_cols=151 Identities=9% Similarity=0.010 Sum_probs=98.6 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|+..+. +.++.++..++.++..+...... .... ....+++.+...+.+.++.++..++.+|..++... T Consensus 54 ~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~d~~~~vr~~a~~~L~~l~~~~ 126 (986) T 2IW3_B 54 HFFGELAKGIK-DKKTAANAMQAVAHIANQSNLSP-----SVEP-YIVQLVPAICTNAGNKDKEIQSVASETLISIVNAV 126 (986) T ss_dssp HHHHHHHHHHT-STTTHHHHHHHHHHHSCTTTCCT-----TTHH-HHHTTHHHHHHHTTCSSHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHhhc-CHHHHHHHHHHHHHHHHhccCCc-----chHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhc Confidence 35666777776 35566676777777766643221 1111 12356777788888788889999999999887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .... ...+++.+...+ .+ .++.++..++.+|..++...+....... ..+++.|..++.+. +..++..|+ T Consensus 127 ~~~~--~~~~l~~l~~~l~~~------~~~~vr~~al~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~d~-~~~vr~~a~ 196 (986) T 2IW3_B 127 NPVA--IKALLPHLTNAIVET------NKWQEKIAILAAFSAMVDAAKDQVALRM-PELIPVLSETMWDT-KKEVKAAAT 196 (986) T ss_dssp CGGG--HHHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHSHHHHHHHH-HHHHHHHHHHTTCS-CHHHHHHHH T ss_pred CHHH--HHHHHHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHCHHHHHhhH-HHHHHHHHHhcCcC-CHHHHHHHH Confidence 2111 224566677777 44 3678889999999988865332221111 34677788888766 778999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..++.. T Consensus 197 ~~l~~l~~~ 205 (986) T 2IW3_B 197 AAMTKATET 205 (986) T ss_dssp HHHHHHGGG T ss_pred HHHHHHHHh Confidence 999888764 No 340 >5NZR_B Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=86.79 E-value=0.04 Score=61.63 Aligned_cols=105 Identities=19% Similarity=0.265 Sum_probs=67.8 Template_Neff=10.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|..++. +.++.++..|+.+|..+..... . ....+..++..+ .+.+..++..++.+|..+... T Consensus 259 ~~~~~L~~~l~-~~~~~vr~~a~~~L~~l~~~~~---------~--~~~~~~~l~~~l~~~~~~~vr~~al~~L~~l~~~ 326 (968) T 5NZR_B 259 RFIRCIYNLLQ-SSSPAVKYEAAGTLVTLSSAPT---------A--IKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEH 326 (968) T ss_dssp HHHHHHHHHTS-CCSHHHHHHHHHHHHHHCCCHH---------H--HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTCC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHhCCCHH---------H--HHHHHHHHHHHHHhcCChHHHHHHHHHHHHHhhC Confidence 35667777777 4667788888888887765311 0 123455566666 566788899999999988753 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ......+ ..+++.+...+.+ .+..++..++.+|..+.. T Consensus 327 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~al~~L~~l~~ 364 (968) T 5NZR_B 327 PAHERVL-QDLVMDILRVLST------PDLEVRKKTLQLALDLVS 364 (968) T ss_dssp TTCCHHH-HHHHHHHHHGGGS------CCHHHHHHHHHHHHTTCS T ss_pred cchHHHH-HHHHHHHHHHhCC------CCHHHHHHHHHHHHHHcC Confidence 2211111 2345556666655 356788888888888765 No 341 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=86.78 E-value=0.037 Score=55.91 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=93.4 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.++.++..++.+|..+....+. . ...+++.+...+.+.++.++..|+.+|..+..... T Consensus 66 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 134 (600) T 4P6Z_B 66 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKI 134 (600) T ss_pred hHHHHHHhcc-CCCHHHHHHHHHHHHHhccCCHh--------H--HHHHHHHHHHHccCCCHHHHHHHHHHHhcCCchHH Confidence 4455666666 46677888888888877653221 1 12355666667777788888889888888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. +....+++.+...+.+. ++.++..++.+ T Consensus 135 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (600) T 4P6Z_B 135 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDS-NPMVVANAVAA 199 (600) T ss_pred -----HHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHhhChHH---hhccChHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 11234567777777766 77888999998 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 200 l~~l~~~~ 207 (600) T 4P6Z_B 200 LSEIAESH 207 (600) T ss_pred HHHHHhhC Confidence 88887653 No 342 >5VCH_A Kap123; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.35A {Kluyveromyces lactis} Probab=86.69 E-value=0.038 Score=60.48 Aligned_cols=153 Identities=11% Similarity=0.110 Sum_probs=80.3 Template_Neff=12.900 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH-PL 627 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~-~e 627 (747) +.+...+. +.++.++..++.++..++..... ... ....+++.++..+ .+.++.++..++.++..+... +. T Consensus 869 ~~l~~~~~-~~~~~~r~~~~~~l~~l~~~~~~------~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~ 940 (1116) T 5VCH_A 869 PVILQLCQ-SKSKNKRSFAVGALSEIALGMRD------ENP-FIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSSF 940 (1116) T ss_dssp HHHHHHTT-CSCHHHHHHHHHHHHHHHHHHGG------GCT-THHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCCS T ss_pred HHHHHHcC-CCCHHHHHHHHHHHHHHHHhCCC------Cch-hHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhCCc Confidence 33444443 24456677777777777653221 111 1134555555553 345678888999999888765 21 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGN----------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~----------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) . ...+ ..+++.+...+...... ......++..++.+|+.+....+... .-..+++.++..+.... T Consensus 941 ~~~~~~-~~il~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~---~~~~~l~~~~~~l~~~~ 1016 (1116) T 5VCH_A 941 DVSAIY-SPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLV---PLEHTIPALLSHLPFNT 1016 (1116) T ss_dssp CCHHHH-HHHHHHHHHHHHHHHHHHHSCSSCHHHHHHHHHHHHHHHHHHHHHHHHCGGGS---CHHHHHHHHHTTCSCSS T ss_pred chhhhH-HHHHHHHHHHhcchhHhccCCCCchhhHHHHHHHHHHHHHHHHHHHHHCcccC---CHHHHHHHHHhcCCCCC Confidence 1 1111 23555565555421000 00245667788888888876533211 11234555555553221 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) +...+..++.+|..+... T Consensus 1017 ~~~~~~~~~~~l~~l~~~ 1034 (1116) T 5VCH_A 1017 AFEEYDPIFKLFLKLFQE 1034 (1116) T ss_dssp CGGGHHHHHHHHHHHHHT T ss_pred chhhhHHHHHHHHHHHHh Confidence 455666677777666653 No 343 >6BCU_A mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP, GTP; 3.43A {Homo sapiens} Probab=86.66 E-value=0.04 Score=67.95 Aligned_cols=131 Identities=8% Similarity=0.114 Sum_probs=72.7 Template_Neff=11.600 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-L 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e 627 (747) ++.|...+.+.....++..++.+|..++..... ....+ -..+++.+...+.+.++.++..++.+|+.++... . T Consensus 952 ~~~l~~~l~~~~~~~~~~~a~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 1025 (2549) T 6BCU_A 952 MVALMRIFRDQSLSHHHTMVVQAITFIFKSLGL-----KCVQF-LPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKS 1025 (2549) T ss_dssp HHHHHHHCSSTTHHHHHHHHHHHHHHHHHHHTT-----GGGGG-HHHHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHHGG T ss_pred HHHHHHHHcCCChHHHHHHHHHHHHHHHHHcCc-----chHHh-HHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHHHH Confidence 555666665222345777888888888764321 11111 2456777778887777788888999998887541 1 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRS 694 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s 694 (747) . ..+. ..+++.+..++.. ...++..++.+|..++........... ..+++.++..+.+ T Consensus 1026 ~~~~~~-~~i~~~l~~~~~~-------~~~v~~~~~~~l~~l~~~~~~~~~~~~-~~l~~~l~~~l~~ 1084 (2549) T 6BCU_A 1026 HIRPYM-DEIVTLMREFWVM-------NTSIQSTIILLIEQIVVALGGEFKLYL-PQLIPHMLRVFMH 1084 (2549) T ss_dssp GGGGGH-HHHHHHHHHTCCS-------CHHHHHHHHHHHHHHHHHHGGGGGGTH-HHHHHHHHHHHHS T ss_pred hcHHhH-HHHHHHHHHHHhc-------CHHHHHHHHHHHHHHHHHhcHhhHhHH-HHHHHHHHHHHhc Confidence 1 1111 2234444444433 244677788888887654222111111 2345555555543 No 344 >6BCX_B mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP; 3.0A {Homo sapiens} Probab=86.66 E-value=0.04 Score=67.95 Aligned_cols=131 Identities=8% Similarity=0.114 Sum_probs=72.7 Template_Neff=11.600 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-L 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e 627 (747) ++.|...+.+.....++..++.+|..++..... ....+ -..+++.+...+.+.++.++..++.+|+.++... . T Consensus 952 ~~~l~~~l~~~~~~~~~~~a~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 1025 (2549) T 6BCX_B 952 MVALMRIFRDQSLSHHHTMVVQAITFIFKSLGL-----KCVQF-LPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKS 1025 (2549) T ss_pred HHHHHHHHcCCChHHHHHHHHHHHHHHHHHcCc-----chHHh-HHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHHHH Confidence 555666665222345777888888888764321 11111 2456777778887777788888999998887541 1 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRS 694 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s 694 (747) . ..+. ..+++.+..++.. ...++..++.+|..++........... ..+++.++..+.+ T Consensus 1026 ~~~~~~-~~i~~~l~~~~~~-------~~~v~~~~~~~l~~l~~~~~~~~~~~~-~~l~~~l~~~l~~ 1084 (2549) T 6BCX_B 1026 HIRPYM-DEIVTLMREFWVM-------NTSIQSTIILLIEQIVVALGGEFKLYL-PQLIPHMLRVFMH 1084 (2549) T ss_pred hcHHhH-HHHHHHHHHHHhc-------CHHHHHHHHHHHHHHHHHhcHhhHhHH-HHHHHHHHHHHhc Confidence 1 1111 2234444444433 244677788888887654222111111 2345555555543 No 345 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=86.43 E-value=0.045 Score=64.20 Aligned_cols=110 Identities=15% Similarity=0.148 Sum_probs=59.4 Template_Neff=9.800 Q NP_000290.2 249 KAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328 (747) Q Consensus 249 ~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~ 328 (747) .+...+.+.+..++..++.+|..++..........+...++..+...+.+.+..++..++.+|..++............. T Consensus 935 ~L~~~L~~~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~~~~l~~~l~ 1014 (1304) T 5IFE_C 935 TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIK 1014 (1304) T ss_pred HHHHHhcCCCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhChHHhcccHH Confidence 33344445566777778888877765322111111112345556666665566777777777777764432111001112 Q NP_000290.2 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 329 ~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .+++.+...+. ..+..++..++.++..++. T Consensus 1015 ~ll~~L~~~L~-~~~~~Vr~~ai~~L~~i~~ 1044 (1304) T 5IFE_C 1015 DLLPRLTPILK-NRHEKVQENCIDLVGRIAD 1044 (1304) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHh Confidence 35555666665 4455667777777776665 No 346 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=86.43 E-value=0.045 Score=64.20 Aligned_cols=110 Identities=15% Similarity=0.148 Sum_probs=59.4 Template_Neff=9.800 Q NP_000290.2 249 KAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328 (747) Q Consensus 249 ~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~ 328 (747) .+...+.+.+..++..++.+|..++..........+...++..+...+.+.+..++..++.+|..++............. T Consensus 935 ~L~~~L~~~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~~~~l~~~l~ 1014 (1304) T 6AHD_1 935 TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIK 1014 (1304) T ss_pred HHHHHhcCCCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhChHHhcccHH Confidence 33344445566777778888877765322111111112345556666665566777777777777764432111001112 Q NP_000290.2 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 329 ~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .+++.+...+. ..+..++..++.++..++. T Consensus 1015 ~ll~~L~~~L~-~~~~~Vr~~ai~~L~~i~~ 1044 (1304) T 6AHD_1 1015 DLLPRLTPILK-NRHEKVQENCIDLVGRIAD 1044 (1304) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHh Confidence 35555666665 4455667777777776665 No 347 >6LTJ_L Histone H3.2, Histone H4, Histone; Chromatin remodeler, Complex, GENE REGULATION; 3.7A {Xenopus laevis} Probab=86.40 E-value=0.056 Score=63.52 Aligned_cols=152 Identities=14% Similarity=0.061 Sum_probs=89.3 Template_Neff=5.100 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-----NSD----------VVRSGASLLSNMSRHPL 627 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-----d~e----------Vr~~AL~aLsnLa~~~e 627 (747) .+++.++.+|.+|+....- .. ....+ ...++..|+.++... ++. .+..|+.+|+.|+..+. T Consensus 1065 ~LRenaLviLaNIAg~LdL--s~-~~e~I-~~~ild~LLhwlv~~sa~a~Dp~~~~~~~~~lSp~~lALEaLsKLsv~d~ 1140 (1295) T 6LTJ_L 1065 MLRENTLVTLANISGQLDL--SP-YPESI-CLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDN 1140 (1295) T ss_dssp HHHHHHHHHHHHHGGGCCC--SS-SCHHH-HHHHHHHHHHHHHCCSSSSSSCCTTSCTTCCCCHHHHHHHHHHHHHTSHH T ss_pred HHHHHHHHHHHHHHcccCC--CC-CChHh-HHHHHHHHHHHHcCcChhcCChhhccCCCCCCCHHHHHHHHHHHHhCCCc Confidence 4566788888888764220 00 01111 112455555554321 111 12348899999987643 Q NP_000290.2 628 LH-RVMG-------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSA-- 696 (747) Q Consensus 628 ~~-~ll~-------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~-- 696 (747) +. .++. ..++..|+.+|... .+..+++.++.+|.+|+........ ...+.+.+..|+.+|+... T Consensus 1141 N~dlLlat~p~srle~Ll~~LV~lL~~~-----ed~~lrE~AL~lL~~Ls~~~~~~ar~ia~~~g~I~~LV~fLE~~~~~ 1215 (1295) T 6LTJ_L 1141 NVDLILATPPFSRLEKLYSTMVRFLSDR-----KNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAA 1215 (1295) T ss_dssp HHHHHHTSSCHHHHHHHHHHHHHHHHHC-----SSHHHHHHHHHHHHHHHHHCHHHHHHHHTSTTHHHHHHHHHHHHHHH T ss_pred hHHHHHhCCCHHHHHHHHHHHHHHhcCC-----CCHHHHHHHHHHHHHHHcCCHHHHHHHHHhcCHHHHHHHHHHHHHHH Confidence 32 2222 23566677777652 2456788999999999875433322 3334567888888876430 Q NP_000290.2 697 ---------------------SPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 697 ---------------------d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ...+++.|+.+|..|+...+-...+.+ T Consensus 1216 ~~~~~~~~~~~~~~npe~~gtS~~m~rRAA~aL~~La~vp~NR~~F~~ 1263 (1295) T 6LTJ_L 1216 TQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTL 1263 (1295) T ss_dssp HHHCC--------------CCCSHHHHHHHHHHHHHHTTSSSHHHHTT T ss_pred HHHHHHHHHHHHhhCCCCCCCCHHHHHHHHHHHHHHhcChhhHHHHHH Confidence 134567788899999887777776665 No 348 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=86.18 E-value=0.043 Score=55.49 Aligned_cols=139 Identities=17% Similarity=0.118 Sum_probs=92.2 Template_Neff=12.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .+..++..+. +.+..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 63 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 131 (585) T 6CRI_R 63 GQLECLKLIA-SQKFTDKRIGYLGAMLLLDERQD--------V--HLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEM 131 (585) T ss_pred HHHHHHHHHh-CCCchHHHHHHHHHHHhCCCChH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHhhCCHHH Confidence 3455666776 46777888888888887754221 1 12345666777777778888888888887764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 132 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~~~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 194 (585) T 6CRI_R 132 -----CRDLAGEVEKLLKT------SNSYLRKKAALCAVHVIRKVPELM-----EMFLPATKNLLNEK-NHGVLHTSVVL 194 (585) T ss_pred -----HHHHHHHHHHHHhC------CChHHHHHHHHHHHHHHHHCHHHH-----HHHHHHHHHHHcCC-CHHHHHHHHHH Confidence 11345556666665 367888899999998876432221 24566777777665 77888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 195 l~~l~~~ 201 (585) T 6CRI_R 195 LTEMCER 201 (585) T ss_pred HHHHHHh Confidence 8887643 No 349 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=85.86 E-value=0.051 Score=64.44 Aligned_cols=292 Identities=12% Similarity=0.004 Sum_probs=157.7 Template_Neff=9.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQ-AIGAYYIQHTCFQDESA--KQQVYQLGGICKLVDLL---RSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr-~sAL~aLsnLs~~~~~~--~~~li~~~IL~~Ll~lL---~s~d~eVr~~AL~aLs~La~~~ 318 (747) .+++.|+..+.+.+..++ ..++..|..+....... ........+++.|+.++ .+.++.++..+..+|..+.... T Consensus 464 ~~i~~L~~~l~d~~~~vR~~~a~~~L~~l~~~~~~~~~~~~~~~~~~lp~Li~~L~~~~d~~~~vr~~aa~~l~~~~~~~ 543 (1460) T 5DFZ_B 464 RVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIII 543 (1460) T ss_pred cchHHHHHHhcCCCHHHHHHHHHHHHHHhcCCCCccCCccccCcCChHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHHc Confidence 455667777777788889 89999998886543211 11223345678888888 7777888888888887774321 Q NP_000290.2 319 TTN------------KLETRRQNGIREAVSL----LRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIP 382 (747) Q Consensus 319 ~~~------------~~~ll~~~IL~~Ll~l----L~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~ 382 (747) ... .........++.+..+ +. +.++.++..++.+|..+........ ....+++.|+.+|..+ T Consensus 544 ~~~~l~~l~~~~~~~~~~~l~~~~~~~l~~ll~~~l~-d~~~~VR~~A~~aL~~l~~~~~~~~-~~~~~l~~Li~ll~d~ 621 (1460) T 5DFZ_B 544 NRFQEFTFAQHCNDNSSTKYSAKLIQSVEDLTVSFLT-DNDTYVKMALLQNILPLCKFFGRER-TNDIILSHLITYLNDK 621 (1460) T ss_pred CHHHHHHHHHhcccChhHHHHcChHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHhccccccc-cHHhHHHHHHHHhcCC Confidence 100 0001111223333333 33 4567889999999988876422111 1135666677766321 Q NP_000290.2 383 FSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCV 462 (747) Q Consensus 383 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 462 (747) +++|-.+|..+|.+--. .++ ....+ ..++..|...+. T Consensus 622 ----------------~~~VR~~a~~aL~~i~~------~~~---------------~~~~~---~~~i~~L~~~l~--- 658 (1460) T 5DFZ_B 622 ----------------DPALRVSLIQTISGISI------LLG---------------TVTLE---QYILPLLIQTIT--- 658 (1460) T ss_pred ----------------CHHHHHHHHHHHHHHHh------hcC---------------chhhc---hhHHHHHHHHhc--- Confidence 35555566666543110 000 00000 011222222111 Q NP_000290.2 463 AASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGW 542 (747) Q Consensus 463 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~ 542 (747) |.. .+| | .+|-.+. +.+.. ..+.. . T Consensus 659 ------d~~----------------~~v--R-----~~a~~aL------~~~~~-----------------~~~~~--~- 683 (1460) T 5DFZ_B 659 ------DSE----------------ELV--V-----ISVLQSL------KSLFK-----------------TGLIR--K- 683 (1460) T ss_pred ------CCC----------------HHH--H-----HHHHHHH------HHhcC-----------------Ccchh--h- Confidence 110 000 0 0111111 00000 00000 0 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ....++++.|..++. +.++.++..|+.+|..+...... . . ....+++.|+.+|.++++.++..|+.+|..+ T Consensus 684 ~~~~~~i~~l~~~l~-d~~~~VR~~A~~al~~l~~~~~~------~-~-~~~~~l~~L~~~l~d~~~~vr~~a~~aL~~~ 754 (1460) T 5DFZ_B 684 KYYIDISKTTSPLLL-HPNNWIRQFTLMIIIEIINKLSK------A-E-VYCILYPIIRPFFEFDVEFNFKSMISCCKQP 754 (1460) T ss_pred cccchhHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC------H-H-HHHHHHHHHHHHhcCCCHHHHHHHHHHhCCC Confidence 001246778888888 57889999999999988764221 1 1 1246788899999999999999999999998 Q NP_000290.2 623 SRHPLLH----RVMGNQVFPEVTRLLT 645 (747) Q Consensus 623 a~~~e~~----~ll~~giI~~Ll~LL~ 645 (747) ....... ..+..+.+..+..++. T Consensus 755 ~~~~~~~~~~~~~~~~~~~~~~~~~~~ 781 (1460) T 5DFZ_B 755 VSRSVYNLLCSWSVRASKSLFWKKIIT 781 (1460) T ss_pred CCHHHHHHHHHHHHHhchhHHHHHHHH Confidence 7763331 2244455555555554 No 350 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=85.76 E-value=0.046 Score=56.33 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=95.8 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS--GNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s--~d~eVr~~AL~aLsnLa 623 (747) .++.|+..+. +.+ ..++..++.+|..++...+. . .... ....+++.+...+.+ .++.++..++.+|..++ T Consensus 4 l~~~l~~~l~-~~~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 77 (762) T 2QNA_A 4 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 77 (762) T ss_pred hHHHHHHHhc-CCCCCHHHHHHHHHHHHHHHHhCCH---h-hcHH-HHHhHHHHHHHHhcCCCCCHHHHHHHHHHHHHHH Confidence 4566777776 344 67888899999888764221 0 0111 113456677777764 35788999999999988 Q NP_000290.2 624 RHP-LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~-e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ... .. . ......+++.+...+.+ .++.++..++.+|..++..............+++.+...+.+. ++.+ T Consensus 78 ~~~~~~~~~~~~~~~i~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~~~~~-~~~v 150 (762) T 2QNA_A 78 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 150 (762) T ss_pred hcCCccCCcchhHHhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHhCchhhHHhhHHhHHHHHHHHcCCC-CHHH Confidence 652 11 1 01122345555566654 3678888999999988764332222222223566666677655 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 151 ~~~a~~~l~~l~~~ 164 (762) T 2QNA_A 151 ALQGIEFWSNVCDE 164 (762) T ss_pred HHHHHHHHHHHHhc Confidence 88888888887754 No 351 >3WOZ_C CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; HET: MSE; 2.2A {Mus musculus} Probab=85.74 E-value=0.049 Score=48.60 Aligned_cols=154 Identities=11% Similarity=0.036 Sum_probs=91.0 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.++..+. +.++..|..++..|..++..... . .... -..++..+...+.+.+..++..++.++..++.. T Consensus 5 ~~~~~~~~~l~-~~~w~~R~~al~~l~~~~~~~~~---~-~~~~--~~~i~~~l~~~l~d~~~~v~~~al~~l~~l~~~~ 77 (232) T 3WOZ_C 5 EDVAEVLNRCA-SSNWSERKEGLLGLQNLLKNQRT---L-SRIE--LKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVH 77 (232) T ss_dssp CCHHHHHHHHT-CSSHHHHHHHHHHHHHHHHTTCC---C-CHHH--HHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCcc---c-CHHH--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHc Confidence 45666777777 47888899999999888864221 0 0111 135666777777777888999999999988865 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.++..+.+. ....++..+..+|..+....+. ..++ ..+++.+...+.+. ++.++..++ T Consensus 78 ~~~~~~~~~~ll~~ll~~l~d~-----~~~~vr~~a~~~l~~i~~~~~~--~~~~-~~l~~~l~~~~~~~-~~~~r~~~l 148 (232) T 3WOZ_C 78 KDDLQDWLFVLLTQLLKKMGAD-----LLGSVQAKVQKALDITRESFPN--DLQF-NILMRFTVDQTQTP-SLKVKVAIL 148 (232) T ss_dssp GGGCTTTHHHHHHHHHHHTTTT-----CCHHHHHHHHHHHHHHHHHSCH--HHHH-HHHHHHHTCTTCCC-CHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHhccc-----cCHHHHHHHHHHHHHHHHHCCc--chHH-HHHHHHhhccccCC-CHHHHHHHH Confidence 2111111123555566555441 1456788888888887543211 1111 12233333344433 567777777 Q NP_000290.2 706 LLLSDMWSSKE 716 (747) Q Consensus 706 ~aLsnL~~~~~ 716 (747) .++..++...+ T Consensus 149 ~~l~~l~~~~~ 159 (232) T 3WOZ_C 149 KYIETLAKQMD 159 (232) T ss_dssp HHHHHHHTTSC T ss_pred HHHHHHHHhcC Confidence 77777665533 No 352 >3WOZ_D CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; HET: MSE; 2.2A {Mus musculus} Probab=85.74 E-value=0.049 Score=48.60 Aligned_cols=154 Identities=11% Similarity=0.036 Sum_probs=91.0 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.++..+. +.++..|..++..|..++..... . .... -..++..+...+.+.+..++..++.++..++.. T Consensus 5 ~~~~~~~~~l~-~~~w~~R~~al~~l~~~~~~~~~---~-~~~~--~~~i~~~l~~~l~d~~~~v~~~al~~l~~l~~~~ 77 (232) T 3WOZ_D 5 EDVAEVLNRCA-SSNWSERKEGLLGLQNLLKNQRT---L-SRIE--LKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVH 77 (232) T ss_dssp CCHHHHHHHHH-CSCHHHHHHHHHHHHHHHHTTCC---C-CHHH--HHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCcc---c-CHHH--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHc Confidence 45666777777 47888899999999888864221 0 0111 135666777777777888999999999988865 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.++..+.+. ....++..+..+|..+....+. ..++ ..+++.+...+.+. ++.++..++ T Consensus 78 ~~~~~~~~~~ll~~ll~~l~d~-----~~~~vr~~a~~~l~~i~~~~~~--~~~~-~~l~~~l~~~~~~~-~~~~r~~~l 148 (232) T 3WOZ_D 78 KDDLQDWLFVLLTQLLKKMGAD-----LLGSVQAKVQKALDITRESFPN--DLQF-NILMRFTVDQTQTP-SLKVKVAIL 148 (232) T ss_dssp GGGCGGGHHHHHHHHHHHTTSC-----CCHHHHHHHHHHHHHHHHHSCH--HHHH-HHHHHHHTCSSCCC-CHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHhccc-----cCHHHHHHHHHHHHHHHHHCCc--chHH-HHHHHHhhccccCC-CHHHHHHHH Confidence 2111111123555566555441 1456788888888887543211 1111 12233333344433 567777777 Q NP_000290.2 706 LLLSDMWSSKE 716 (747) Q Consensus 706 ~aLsnL~~~~~ 716 (747) .++..++...+ T Consensus 149 ~~l~~l~~~~~ 159 (232) T 3WOZ_D 149 KYIETLAKQMD 159 (232) T ss_dssp HHHHHHHTTCC T ss_pred HHHHHHHHhcC Confidence 77777665533 No 353 >5DCQ_C artificial repeat proteins (alphaREP3), Fibronectin-binding; adhesin, artificial repeat proteins, complex; HET: FMT; 1.83A {synthetic construct} Probab=85.49 E-value=0.051 Score=45.36 Aligned_cols=47 Identities=15% Similarity=0.166 Sum_probs=25.2 Template_Neff=12.100 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) ++.++..++.+|..+... ..++.+..++.+. +..++..++.++..+. T Consensus 120 ~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~ 166 (170) T 5DCQ_C 120 DSDVRRTAAYALGEIGGE-----------RVRAAMEKLAETG-TGFARKVAVNYLETHK 166 (170) T ss_dssp SHHHHHHHHHHHHHHCHH-----------HHHHHHHHHHHHC-CHHHHHHHHHHHHTC- T ss_pred CHHHHHHHHHHHHHhchH-----------HHHHHHHHHHHcC-ChHHHHHHHHHHHhcc Confidence 455666666666555431 1344444555544 5566666766666543 No 354 >4L7M_A Putative uncharacterized protein; HEAT-repeats, Hypothetical, UNKNOWN FUNCTION; HET: MSE, GOL; 2.002A {Thermococcus onnurineus} Probab=85.26 E-value=0.051 Score=48.13 Aligned_cols=143 Identities=17% Similarity=0.105 Sum_probs=85.7 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... . .....++.+..++.+.++.++..++.++..++.... T Consensus 120 ~~~~l~~~l~-~~~~~~~~~a~~~l~~~~~~--~----------~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~ 186 (269) T 4L7M_A 120 AAKTLVSLLE-SPDDMMRIETIDVLSKLQPL--E----------DSKLVRTYINELVVSPDLYTKVAGFCLFLNMLNSSA 186 (269) T ss_dssp HHHHHHHHTT-SCCHHHHHHHHHHHTTCCBS--C----------CCHHHHHHHHHHHHCSSHHHHHHHHHHHHHHGGGCS T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHhcCCh--h----------HhhchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCC Confidence 4556666666 35666777777777665321 0 123566777777877778889999999998875311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRS--SASPKAAEAA 704 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s--~~d~eVr~aA 704 (747) ..... ..+++.+...+.+ .++.++..++.+|..+..... ....... +.+..++..+.+ . ++.++..+ T Consensus 187 ~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~--~~~~~l~~~l~~~~~-~~~vr~~a 256 (269) T 4L7M_A 187 DSGHL-TLILDEIPSLLQN------DNEFIVELALDVLEKALSFPLLENVKIEL--LKISRIVDGLVYREG-APIIRLKA 256 (269) T ss_dssp SCCCG-GGTTTTHHHHHTC------SCHHHHHHHHHHHHHHTTSCCCSCCHHHH--HHHHHHHHHHTTCSS-CHHHHHHH T ss_pred CcchH-HHHHHHHHHHHcC------CCHHHHHHHHHHHHHHcCCccHHHHHHHH--HHHHHHHhhccCCCC-CHHHHHHH Confidence 11111 1245556666665 367888899999988875411 1111111 233344444443 3 67788888 Q NP_000290.2 705 RLLLSDMWS 713 (747) Q Consensus 705 L~aLsnL~~ 713 (747) +.+|..+.. T Consensus 257 ~~~l~~l~~ 265 (269) T 4L7M_A 257 KKVSDLIDS 265 (269) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 888877653 No 355 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=85.10 E-value=0.053 Score=54.64 Aligned_cols=109 Identities=13% Similarity=0.033 Sum_probs=65.8 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+..........+++.+...+.+.+..++..++.++..+....... T Consensus 176 ~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~~~~~~~~~--- 252 (600) T 4P6Z_B 176 GFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDRE--- 252 (600) T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCCCcchhccCHHHHHHHHHHhhcCCHHHHHHHHHHHHHhCCCCHHH--- Confidence 35566666676777788888888888887643321111112245555666666556667777777777766432211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++..+...+. +.++.++..++.++..+.. T Consensus 253 --~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 284 (600) T 4P6Z_B 253 --AQSICERVTPRLS-HANSAVVLSAVKVLMKFME 284 (600) T ss_pred --HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHH Confidence 1234555555565 4566777788888777765 No 356 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=85.09 E-value=0.053 Score=50.69 Aligned_cols=101 Identities=9% Similarity=0.074 Sum_probs=54.4 Template_Neff=12.800 Q NP_000290.2 598 PQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK 677 (747) Q Consensus 598 ~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~ 677 (747) +.+...+.+.++.++..++.+|..+...... ....+++.+...+.+ .+..++..++.+|..+... .. T Consensus 191 ~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-~~--- 257 (373) T 5MU7_A 191 GTVFEGIPNAEELLQLVEIEFIRKDALHNPQ---NKPRYLRLIFDLLEA------NTSTVVYEAASSLTALTNN-PV--- 257 (373) T ss_dssp HHTGGGGGGSCHHHHHHHHHHHHHHHHHCGG---GHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHCCC-HH--- T ss_pred HHHHhcCCChhHHHHHHHHHHHHHHhccCcc---cHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHcCCC-HH--- Confidence 3344444444444444455444444332100 012344555555544 2556677777777776542 11 Q NP_000290.2 678 QYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 678 ~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~ 714 (747) .. ...++.+...+. +. ++.++..++.+|..+... T Consensus 258 -~~-~~~~~~l~~~l~~~~-~~~vr~~a~~~l~~l~~~ 292 (373) T 5MU7_A 258 -AV-KAAAGKFIELAIKEA-DNNVKLIVLDRVDQLRQK 292 (373) T ss_dssp -HH-HHHHHHHHHHHHHCC-CHHHHHHHHHHHHHHHHH T ss_pred -HH-HHHHHHHHHHHhhCC-ChhHHHHHHHHHHHHHHh Confidence 11 135666777776 44 778888888888888865 No 357 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=84.97 E-value=0.056 Score=55.88 Aligned_cols=142 Identities=13% Similarity=0.105 Sum_probs=95.5 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. ++++.++..++.++..+....+. . ...+++.+...+.+.++.++..++.+++.+..... T Consensus 50 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 118 (657) T 4UQI_B 50 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKI 118 (657) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHh--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCchh Confidence 4555666676 46677888888888887764221 1 13456667777777788889999999988864311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. +....+++.+..++.+. ++.++..++.+ T Consensus 119 -----~~~l~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 183 (657) T 4UQI_B 119 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQM---VEDQGFLDSLRDLIADS-NPMVVANAVAA 183 (657) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHH---hcCcchHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 12234567777777766 77889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 184 l~~l~~~~ 191 (657) T 4UQI_B 184 LSEISESH 191 (657) T ss_pred HHHHHhcC Confidence 88887654 No 358 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=84.94 E-value=0.055 Score=53.37 Aligned_cols=149 Identities=8% Similarity=0.061 Sum_probs=96.3 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLM-GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL-~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+ . +.++.++..++.++..++..... . .... ....+++.+...+.+.+..++..++.+|..++... T Consensus 340 ~~~~l~~~l~~-d~~~~v~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 413 (536) T 6MZE_Z 340 YLRVLANVIQK-DANVQAVTIAANSVQLLCNSLRS---N-FTRS-YGAIVLVPLLERTKEKKPSVNEAICSALDAVATYC 413 (536) T ss_dssp THHHHHHHHHH-CSCHHHHHHHHHHHHHHHHHTTT---C-CSSH-HHHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHhc-CchHHHHHHHHHHHHHHHHHccc---c-ccHH-HHHHHHHHHHHHhhccCHHHHHHHHHHHHHHHHhc Confidence 556666776 5 46778888999999988764221 0 0101 12356677777777777788888988888887542 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-------KQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-------~~Lve~giL~~Ll~LL~s~~d~e 699 (747) .. ..+++.+...+.+ .++.++..++.+|..+........ ... ...+++.+...+.+. +.. T Consensus 414 ~~-----~~~~~~l~~~l~~------~~~~vr~~~l~~l~~~~~~~~~~~~~~~~~~~~~-~~~i~~~l~~~l~~~-~~~ 480 (536) T 6MZE_Z 414 GF-----DDCLEETLNYMKH------KTPQVRIECTKFLTRMLQGWKSDGPLQNQLLFKL-LPEVTTAVLKIVNDT-QPT 480 (536) T ss_dssp TT-----SSHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHTCCCCSSSCCHHHHTC-CCCCCHHHHHHHTCS-SHH T ss_pred CH-----HHHHHHHHHHHcc------CCHHHHHHHHHHHHHHHhcCCCCCchhhHHHHHH-HHHHHHHHHHHHcCC-CHH Confidence 11 1244555555554 367788889999888876432210 011 123566677777765 778 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ++..++.++..+.... T Consensus 481 vr~~a~~~l~~l~~~~ 496 (536) T 6MZE_Z 481 TRNTGFECFATLMKLV 496 (536) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 9999999999888654 No 359 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=84.81 E-value=0.067 Score=56.37 Aligned_cols=117 Identities=12% Similarity=0.116 Sum_probs=82.7 Template_Neff=8.700 Q NP_000290.2 610 DVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP---------QLAKQY 679 (747) Q Consensus 610 eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---------e~~~~L 679 (747) .....++.+|.+|+..+.. ..++..++++.|+.+|.+ .+..+...++.+|.+|+.... .....+ T Consensus 42 ~~L~~ai~~L~~La~~p~~~~~lv~~g~i~~Lv~LL~~------~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l 115 (490) T 4MFU_A 42 LDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGH------DNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDAL 115 (490) T ss_dssp HHHHHHHHHHHTTTTSCCCTHHHHHTTHHHHHHHHTSC------SSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHH T ss_pred HHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHhCC------CCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHH Confidence 3445678888888876544 455667889999999976 356788899999999987532 235566 Q NP_000290.2 680 FSSSMLNNIINLCRS------SASPKAAEAARLLLSDMWSSK-ELQGVLRQQGFDRNMLGT 733 (747) Q Consensus 680 ve~giL~~Ll~LL~s------~~d~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~~~~~~~~ 733 (747) .+.++++.|+.+|.. . +...+..++.+|.+|+... +....+.+.|+-..++.. T Consensus 116 ~~~g~l~~Lv~~L~~~~e~~~~-d~~~~~~al~~L~nL~~~~~~~~~~i~~~~~l~~Ll~~ 175 (490) T 4MFU_A 116 VDGQVVALLVQNLERLDESVKE-EADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKR 175 (490) T ss_dssp HHTTHHHHHHHHHHHCCTTCHH-HHHHHHHHHHHHHHHHHHSTTHHHHHCCCCCHHHHHHH T ss_pred HhCCHHHHHHHHHHhccccccc-hHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHH Confidence 677888889888875 3 5677889999999998754 444445555554444433 No 360 >5N3U_B Phycocyanobilin lyase subunit alpha (E.C.4.-.-.-); phycobilisome, chromophorylation, phycocyanin, lyase; 1.89A {Nostoc sp. PCC 7120} Probab=84.57 E-value=0.06 Score=46.12 Aligned_cols=135 Identities=14% Similarity=0.143 Sum_probs=82.4 Template_Neff=12.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) +.++.|...+. +.++.++..++.+|..+.. ..++.+...+.+.++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~-----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~- 92 (208) T 5N3U_B 32 AAIPTLIAVFG-YNNPTAAAIASTALVQLGE-----------------VAVPQLLTQIDDYNYGARAYSIRTLAAIADP- 92 (208) T ss_dssp GGHHHHHHHTT-SCCHHHHHHHHHHHHHHGG-----------------GGHHHHHHCCCTTCHHHHHHHHHHHHHHCCG- T ss_pred hhHHHHHHHhC-CCCHHHHHHHHHHHHHhCc-----------------chHHHHHHHhhCCCHHHHHHHHHHHHHhcCc- Confidence 45666777776 3566677777776655432 1334455666667778888888888776522 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-KQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..++.+...+... .++.++..++.+|..+........ ........++.+..++.+. ++.++..++ T Consensus 93 --------~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 158 (208) T 5N3U_B 93 --------RALDVLIDAAATD-----FAPSVRRAAAKGLGNLHWHKLEFPDNQTAPKKALETLLFISQDA-EWSIRYAAI 158 (208) T ss_dssp --------GGHHHHHHHHHHC-----CCHHHHHHHHHHHTTSCGGGSCTTHHHHHHHHHHHHHHHHTTCS-SHHHHHHHH T ss_pred --------chHHHHHHHHccC-----CCHHHHHHHHHHHHhhhccCCCCCCCccCChHHHHHHHHHhcCC-CHHHHHHHH Confidence 2344555555431 256788888888888864221111 1111123566666777665 677888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 159 ~~l~~~~~~ 167 (208) T 5N3U_B 159 VGLQGLVNI 167 (208) T ss_dssp HHHHHGGGC T ss_pred HHHHHHcCC Confidence 888887764 No 361 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=84.43 E-value=0.06 Score=53.82 Aligned_cols=145 Identities=12% Similarity=0.031 Sum_probs=94.1 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..+....+. ......+++.+...+.+.++.++..++.+|..+..... T Consensus 122 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~--------~~~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~~~~~~~ 192 (592) T 6QH5_B 122 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192 (592) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCch--------hhcCccHHHHHHHHhCCCCHHHHHHHHHHHHHHHhcCC Confidence 4566667776 46788889999999988764221 11224677788888888888899999999998886521 Q NP_000290.2 628 --LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 --~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ........+++.+...+.+ .++.++..++.+|..+....+.. ....++.+...+.+. ++.++..++ T Consensus 193 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 260 (592) T 6QH5_B 193 NSNLLDLNPQNINKLLTALNE------CTEWGQIFILDCLSNYNPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 260 (592) T ss_pred hhhhHhHHhhHHHHHHHHhcC------CCHHHHHHHHHHHHHHhcCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1111122355566666654 25677778888888877542221 112455555666655 677888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 261 ~~l~~l~~ 268 (592) T 6QH5_B 261 KVLMKFLE 268 (592) T ss_pred HHHHHHHh Confidence 88877763 No 362 >2DB0_A 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=84.35 E-value=0.062 Score=47.21 Aligned_cols=104 Identities=10% Similarity=0.179 Sum_probs=59.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|+..+. +.++.++..++.+|..+...... . ...+++.+...+.+. ++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~ 100 (253) T 2DB0_A 32 SVLKKLIELLD-DDLWTVVKNAISIIMVIAKTRED--------L--YEPMLKKLFSLLKKSEAIPLTQEIAKAFGQMAKE 100 (253) T ss_dssp HHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCGG--------G--HHHHHHHHHHHHHHCCSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHhhCHH--------H--HHHHHHHHHHHHhcCCChhHHHHHHHHHHHHHHh Confidence 45666777776 46677888888888777643110 0 122445566666666 677888888888777643 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... .+ ...++.+...+.+ .++.++..++.++..+.. T Consensus 101 ~~~--~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 136 (253) T 2DB0_A 101 KPE--LV-KSMIPVLFANYRI------GDEKTKINVSYALEEIAK 136 (253) T ss_dssp CHH--HH-HHHHHHHHHHSCC------CSHHHHHHHHHHHHHHHH T ss_pred CHH--HH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 110 00 1133444444444 245556666666665544 No 363 >2DB0_B 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=84.35 E-value=0.062 Score=47.21 Aligned_cols=104 Identities=10% Similarity=0.179 Sum_probs=59.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|+..+. +.++.++..++.+|..+...... . ...+++.+...+.+. ++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~ 100 (253) T 2DB0_B 32 SVLKKLIELLD-DDLWTVVKNAISIIMVIAKTRED--------L--YEPMLKKLFSLLKKSEAIPLTQEIAKAFGQMAKE 100 (253) T ss_dssp HHHHHHHHHTT-CSSHHHHHHHHHHHHHHGGGCGG--------G--HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHhhCHH--------H--HHHHHHHHHHHHhcCCChhHHHHHHHHHHHHHHh Confidence 45666777776 46677888888888777643110 0 122445566666666 677888888888777643 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... .+ ...++.+...+.+ .++.++..++.++..+.. T Consensus 101 ~~~--~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 136 (253) T 2DB0_B 101 KPE--LV-KSMIPVLFANYRI------GDEKTKINVSYALEEIAK 136 (253) T ss_dssp CHH--HH-HHHHHHHTTTCCC------CSHHHHHHHHHHHHHHHH T ss_pred CHH--HH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 110 00 1133444444444 245556666666665544 No 364 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=84.21 E-value=0.064 Score=54.84 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=93.7 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (623) T 2JKT_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (623) T ss_dssp CHHHHHHHTT-CSCHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHTTCHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCccHHHHHHHHHHHhcCCCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHhhCCHHH Confidence 4566777777 46778888888888887653221 1 12355667777777788899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~~~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (623) T 2JKT_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (623) T ss_dssp -----HHHHTTHHHHHHHCTT------SCHHHHHHHHHHHHHHHHHCTTT---CCCCTHHHHHHGGGGCS-SHHHHHHHH T ss_pred -----HHHHHHhHHHHHHcCC------CCHHHHHHHHHHHHHHHHHChhh---cCccchHHHHHHHhcCC-CHHHHHHHH Confidence 112445556666 44 36788999999999887642221 11234567777777766 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~l~~l~~ 216 (623) T 2JKT_A 209 SLITTLAQ 216 (623) T ss_dssp HHHHHHHT T ss_pred HHHHHHHH Confidence 88888775 No 365 >3LTJ_A AlphaRep-4; protein engineering, HEAT-like repeat, PROTEIN; 1.8A {synthetic} Probab=84.11 E-value=0.065 Score=45.71 Aligned_cols=28 Identities=11% Similarity=0.126 Sum_probs=18.0 Template_Neff=12.300 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+...+.+. +..++..++.++..+.. T Consensus 140 ~~~l~~~l~~~-~~~v~~~a~~~l~~~~~ 167 (201) T 3LTJ_A 140 VEPLIKALKDE-DGWVRQSAADALGEIGG 167 (201) T ss_dssp HHHHHHHTTCS-SHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHhCC-ChHHHHHHHHHHHHhCc Confidence 44455555544 56777778888777664 No 366 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=84.10 E-value=0.065 Score=53.98 Aligned_cols=145 Identities=12% Similarity=0.047 Sum_probs=94.3 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..+....+. .+....+++.+...+.+.++.++..++.+|..+.... T Consensus 138 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 208 (600) T 4P6Z_B 138 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------LVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHP 208 (600) T ss_pred HHHHHHHhcC-CCCHHHHHHHHHHHHHHHhhChH--------HhhccChHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCC Confidence 4566677776 46778888999999988764321 1112457778888888888899999999999888652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ........+++.+...+.+ .+..++..++.+|..+....+.. ....++.+...+.+. +..++..++ T Consensus 209 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 276 (600) T 4P6Z_B 209 SSNLLDLNPQSINKLLTALNE------CTEWGQIFILDCLANYMPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 276 (600) T ss_pred CcchhccCHHHHHHHHHHhhc------CCHHHHHHHHHHHHHhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111122355556666654 25677778888888876542221 123455566666655 677788888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 277 ~~l~~l~~ 284 (600) T 4P6Z_B 277 KVLMKFME 284 (600) T ss_pred HHHHHHHH Confidence 88777764 No 367 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=84.02 E-value=0.067 Score=54.81 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=93.1 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (621) T 6QH7_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (621) T ss_dssp CHHHHHHHTT-CSSHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCccHHHHHHHHHHHHcCCCHH--------H--HHHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHHH Confidence 4556667776 46777888888888887754221 1 12345666677777788899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~~~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (621) T 6QH7_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (621) T ss_dssp -----HHHHTTHHHHHHTTSC------CCHHHHHHHHHHHHHHHHHCGGG---CCCCTTHHHHHHGGGCS-SHHHHHHHH T ss_pred -----HHHHHhhHHHHHHcCC------CCHHHHHHHHHHHHHHHHHChhh---cCccchHHHHHHHhcCC-CHHHHHHHH Confidence 112445556666 44 36788999999999887643221 11234567777777765 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~l~~l~~ 216 (621) T 6QH7_A 209 SLITTLAQ 216 (621) T ss_dssp HHHHHHHT T ss_pred HHHHHHHH Confidence 88888775 No 368 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=83.93 E-value=0.067 Score=53.93 Aligned_cols=67 Identities=18% Similarity=0.165 Sum_probs=49.2 Template_Neff=12.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+...+. +.++.++..++.+|..+....+. . ...+++.|...+.+.++.++..++.+|..+... T Consensus 135 ~~~~l~~~l~-~~~~~vr~~a~~~L~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 201 (585) T 6CRI_R 135 LAGEVEKLLK-TSNSYLRKKAALCAVHVIRKVPE--------L--MEMFLPATKNLLNEKNHGVLHTSVVLLTEMCER 201 (585) T ss_pred HHHHHHHHHh-CCChHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHh Confidence 4566777777 46778888999999888764221 1 135677788888878888999999999888754 No 369 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=83.87 E-value=0.069 Score=55.16 Aligned_cols=145 Identities=12% Similarity=0.031 Sum_probs=94.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..+....+. .+....+++.+..++.+.++.++..++.+|..+..... T Consensus 122 l~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 192 (657) T 4UQI_B 122 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192 (657) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHH--------HhcCcchHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCC Confidence 4566667776 46778888999999988764321 11224677788888888888899999999999887521 Q NP_000290.2 628 --LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 --~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ........+++.+...+.+ .++.++..++.+|..+....... ...+++.+...+.+. +..++..++ T Consensus 193 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~L~~l~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 260 (657) T 4UQI_B 193 NSNLLDLNPQNINKLLTALNE------CTEWGQIFILDCLSNYNPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 260 (657) T ss_pred hhhhhhhhhcHHHHHHHHhcC------CCHHHHHHHHHHHHhhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1111123355666666655 35677888888888887542221 112455566666555 667777777 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 261 ~~l~~l~~ 268 (657) T 4UQI_B 261 KVLMKFLE 268 (657) T ss_pred HHHHHHHh Confidence 77777663 No 370 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=83.55 E-value=0.071 Score=50.49 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=83.6 Template_Neff=12.900 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHP-LLHRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~-e~~~ll~~giI~ 638 (747) ++.++..++.++..++..... . ....+ -..+++.+...+.+. +..++..++.++..++... .........+++ T Consensus 163 ~~~v~~~a~~~l~~l~~~~~~---~-~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~ 237 (416) T 5XAH_A 163 DAMLLEHAGEAIPALAAAAGG---D-SFAPF-FAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLP 237 (416) T ss_dssp HHHHHHHHHHHHHHHHHHHTS---T-TTHHH-HHHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHHHHGGGGGGGHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCc---c-chHHH-HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHH Confidence 455667778888777654210 0 01111 133556666666543 3567778888888877541 111111123566 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+ .++.++..++.+|..++...+......+ ..+++.+...+. +. ++.++..++.++..++... T Consensus 238 ~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~-~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_A 238 VLLSTAQE------ADPEVRSNAIFGMGVLAEHGGHPAQEHF-PKLLGLLFPLLARER-HDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHTSC------SSHHHHHHHHHHHHHHHHHHHHHHHTTH-HHHHHHHTTHHHHCC-CHHHHHHHHHHHHHHHHHC T ss_pred HHHHHhhc------CCHHHHHHHHHHHHHHHHhcCchHHhhH-HHHHHHHHHHhccCC-CHHHHHHHHHHHHHHHHhC Confidence 66666655 3678889999999998865332222222 235666777776 44 6778888888888877543 No 371 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=83.55 E-value=0.071 Score=50.49 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=83.6 Template_Neff=12.900 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHP-LLHRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~-e~~~ll~~giI~ 638 (747) ++.++..++.++..++..... . ....+ -..+++.+...+.+. +..++..++.++..++... .........+++ T Consensus 163 ~~~v~~~a~~~l~~l~~~~~~---~-~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~ 237 (416) T 5XAH_C 163 DAMLLEHAGEAIPALAAAAGG---D-SFAPF-FAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLP 237 (416) T ss_dssp HHHHHHHHHTHHHHHHHHHTS---T-TTHHH-HHHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHHHHGGGGGGGHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCc---c-chHHH-HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHH Confidence 455667778888777654210 0 01111 133556666666543 3567778888888877541 111111123566 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+ .++.++..++.+|..++...+......+ ..+++.+...+. +. ++.++..++.++..++... T Consensus 238 ~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~-~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_C 238 VLLSTAQE------ADPEVRSNAIFGMGVLAEHGGHPAQEHF-PKLLGLLFPLLARER-HDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHTTC------SSHHHHHHHHHHHHHHHHHSHHHHHTTH-HHHHHHHTHHHHHCC-CHHHHHHHHHHHHHHHHTS T ss_pred HHHHHhhc------CCHHHHHHHHHHHHHHHHhcCchHHhhH-HHHHHHHHHHhccCC-CHHHHHHHHHHHHHHHHhC Confidence 66666655 3678889999999998865332222222 235666777776 44 6778888888888877543 No 372 >5FRS_A SISTER CHROMATID COHESION PROTEIN PDS5; COHESIN, DNA REPLICATION, SISTER CHROMATID; 4.073A {SACCHAROMYCES CEREVISIAE} Probab=83.54 E-value=0.08 Score=57.55 Aligned_cols=149 Identities=7% Similarity=0.080 Sum_probs=99.5 Template_Neff=9.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.|...+. +.++.++..|+.+|..+....+. . .... ....+++.++..+.+.++.++..++.++..+... + T Consensus 282 vl~~L~~~l~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~vR~~a~~~l~~~~~~~~ 355 (703) T 5FRS_A 282 VIGFIYHELS-SENELFRKEATKLIGQILTSYSD---L-NFVS-THSDTFKAWISKIADISPDVRVEWTESIPQIIATRE 355 (703) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCCc---c-cHHH-HchhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhCH Confidence 5666666676 46778899999999988764221 0 0011 1245667777777778889999999999988764 2 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..|+.+|+.+..... .........++.+...+.+. +..++..|+. T Consensus 356 ~~----~~~i~~~l~~~l~D------~d~~VR~~A~~~L~~~~~~~~--~~~~~~~~~l~~l~~~l~d~-~~~VR~~A~~ 422 (703) T 5FRS_A 356 DI----SKELNQALAKTFID------SDPRVRRTSVMIFNKVPVTEI--WKNITNKAIYTSLLHLAREK-HKEVRELCIN 422 (703) T ss_pred HH----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHhhcccCc--cccCCCcccHHHHHHHhcCC-CHHHHHHHHH Confidence 11 22356666666666 478999999999998865321 00111234567777777766 7789999999 Q NP_000290.2 707 LLSDMWSSK 715 (747) Q Consensus 707 aLsnL~~~~ 715 (747) +|..+.... T Consensus 423 ~L~~l~~~~ 431 (703) T 5FRS_A 423 TMAKFYSNS 431 (703) T ss_pred HHHHHHHhC Confidence 888777543 No 373 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=83.50 E-value=0.087 Score=56.79 Aligned_cols=136 Identities=13% Similarity=0.067 Sum_probs=87.4 Template_Neff=8.100 Q NP_000290.2 246 TIPKAVQYLSS------QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP--NQNVQQAAAGALRNLVFR 317 (747) Q Consensus 246 iL~~Ll~lL~s------sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~--d~eVr~~AL~aLs~La~~ 317 (747) +++.|+..+.. .+...+..++.+|.+++...+.....+...++++.|+.++... ....+..+..+|..++.. T Consensus 198 ~l~~Lv~~L~~l~e~~~~d~~~~~~al~iL~nL~~~~~~~~~~i~~~g~l~~Ll~lL~~~~~~~~~k~~AaeiL~~L~~~ 277 (568) T 4HM9_A 198 VVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQD 277 (568) T ss_dssp HHHHHHHHHTTCCTTSHHHHHHHHHHHHHHHHHHHHCGGGHHHHCCCCCHHHHHHHHHSSCCCCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHhcccccccchHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcC Confidence 44555555554 4556778888999988865433333344456788888888764 466788889999988865 Q NP_000290.2 318 STTNKLETRRQNGIREAVSLLRR-----TG---NAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 318 ~~~~~~~ll~~~IL~~Ll~lL~s-----s~---d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) .......+...+.++.|+.++.. .. .......++.+|..++........++. ++++.|+.+|+. T Consensus 278 ~~~~r~~l~~~g~I~~LL~lL~~y~~~d~~~~~e~e~~en~~~aL~~L~~~~~~r~~f~~~~gv~lLv~lL~~ 350 (568) T 4HM9_A 278 NDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE 350 (568) T ss_dssp CHHHHHHHHHTTHHHHHHHHHGGGTTSCCSSSHHHHHHHHHHHHHHHHTTSTHHHHHHHHTTHHHHHHHHHHH T ss_pred CHHHHHHHHhCchHHHHHHHHHhhhccCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCChHHHHHHHHhC Confidence 44444444445677777777731 11 123444557788887766555555555 778888888875 No 374 >5FRP_A SISTER CHROMATID COHESION PROTEIN PDS5; CELL CYCLE, CELL DIVISION, COHESIN; 2.895A {SACCHAROMYCES CEREVISIAE} Probab=83.43 E-value=0.082 Score=57.48 Aligned_cols=149 Identities=7% Similarity=0.080 Sum_probs=99.6 Template_Neff=9.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.|...+. +.++.++..|+.+|..+....+. . .... ....+++.++..+.+.++.++..++.++..+... + T Consensus 282 vl~~L~~~l~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~vR~~a~~~l~~~~~~~~ 355 (703) T 5FRP_A 282 VIGFIYHELS-SENELFRKEATKLIGQILTSYSD---L-NFVS-THSDTFKAWISKIADISPDVRVEWTESIPQIIATRE 355 (703) T ss_dssp THHHHHHHHT-CSSHHHHHHHHHHHHHHTTSCCS---S-CHHH-HTHHHHHHHHGGGGCSSHHHHHHHHHTHHHHHHHCC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCC---c-CHHH-HCHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCH Confidence 5666666676 46778899999999988764221 0 0011 1245667777777778889999999999988764 2 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..|+.+|+.+..... .........++.+...+.+. +..++..|+. T Consensus 356 ~~----~~~i~~~l~~~l~D------~d~~VR~~A~~~L~~~~~~~~--~~~~~~~~~l~~l~~~l~d~-~~~VR~~A~~ 422 (703) T 5FRP_A 356 DI----SKELNQALAKTFID------SDPRVRRTSVMIFNKVPVTEI--WKNITNKAIYTSLLHLAREK-HKEVRELCIN 422 (703) T ss_dssp SC----SSHHHHHHHHHTTC------SSHHHHHHHHHHHHHSCHHHH--HHHCCCHHHHHHHHHGGGBS-CHHHHHHHHH T ss_pred HH----HHHHHHHHHHHhcC------CCHHHHHHHHHHHhhcChhHH--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 22356666677666 478999999999998865311 00111234567777777766 7789999999 Q NP_000290.2 707 LLSDMWSSK 715 (747) Q Consensus 707 aLsnL~~~~ 715 (747) +|..+.... T Consensus 423 ~L~~l~~~~ 431 (703) T 5FRP_A 423 TMAKFYSNS 431 (703) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 888777543 No 375 >5GM6_G Prp8, Brr2, Snu114, Rse1, Cus1; spliceosome, RNA splicing, Bact, Catalytically; HET: GTP, ADP, ZN; 3.5A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=83.42 E-value=0.077 Score=58.66 Aligned_cols=69 Identities=9% Similarity=-0.111 Sum_probs=31.7 Template_Neff=11.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++. T Consensus 603 ~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~v~~~a~~~l~~l~~ 671 (971) T 5GM6_G 603 STILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITS 671 (971) T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 333344444455566666665555543211111100111234444444444445566666666666554 No 376 >5ZWM_1 Pre-mRNA-splicing factor 8, U4/U6 small; spliceosome, assembly, pre-B complex, U1; HET: GTP; 3.4A {Saccharomyces cerevisiae S288c} Probab=83.42 E-value=0.077 Score=58.66 Aligned_cols=69 Identities=9% Similarity=-0.111 Sum_probs=31.7 Template_Neff=11.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++. T Consensus 603 ~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~v~~~a~~~l~~l~~ 671 (971) T 5ZWM_1 603 STILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITS 671 (971) T ss_dssp HHHHHHTTCSSHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 333344444455566666665555543211111100111234444444444445566666666666554 No 377 >3TJZ_B ADP-ribosylation factor 1, Coatomer subunit; protein trafficking, Golgi membrane, protein; HET: GNP; 2.9A {Saccharomyces cerevisiae} Probab=83.38 E-value=0.075 Score=50.15 Aligned_cols=102 Identities=16% Similarity=0.082 Sum_probs=56.5 Template_Neff=12.100 Q NP_000290.2 596 GLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 596 iI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) .++.+..++.+.+..++..++.+|..+...... ....+++.+..++.+ .++.++..++.+|..+....+.. T Consensus 251 ~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~ 321 (355) T 3TJZ_B 251 LFDFIESCLRNKHEMVVYEAASAIVNLPGCSAK---ELAPAVSVLQLFCSS------PKAALRYAAVRTLNKVAMKHPSA 321 (355) T ss_pred HHHHHHHHhCCCCHHHHHHHHHHHHHHccCCHH---HHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCHHH Confidence 445555556555666666666666666543100 001233444444444 25667777778877776532211 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) . ...++.+..++.+. +..++..|+.+|..+. T Consensus 322 ~-----~~~~~~l~~~l~~~-~~~vr~~a~~~L~~l~ 352 (355) T 3TJZ_B 322 V-----TACNLDLENLVTDA-NRSIATLAITTLLKTG 352 (355) T ss_pred H-----HHHHHHHHHHhcCC-CHHHHHHHHHHHHHhh Confidence 1 12335566666655 6677888888777764 No 378 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=83.30 E-value=0.075 Score=53.54 Aligned_cols=101 Identities=12% Similarity=0.040 Sum_probs=51.9 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 100 ~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~~~~~~~~~~--- 169 (585) T 6CRI_R 100 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSE-------MCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELM--- 169 (585) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHhhCCHH-------HHHHHHHHHHHHHhCCChHHHHHHHHHHHHHHHHCHHHH--- Confidence 4444444555555566666666665554211 011234445555555556666666666666654322111 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..+++.+...+. +.++.++..++.++..+.. T Consensus 170 --~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 200 (585) T 6CRI_R 170 --EMFLPATKNLLN-EKNHGVLHTSVVLLTEMCE 200 (585) T ss_pred --HHHHHHHHHHHc-CCCHHHHHHHHHHHHHHHH Confidence 234445555554 4455666666666666654 No 379 >6U62_A Regulatory-associated protein of mTOR, Ras-related; signaling complex, GTPase, lysosome, SIGNALING; HET: GDP, GTP;{Homo sapiens} Probab=83.02 E-value=0.095 Score=62.46 Aligned_cols=159 Identities=10% Similarity=0.013 Sum_probs=98.7 Template_Neff=8.000 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSN 621 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsn 621 (747) ...|+++.++++|++ ...+.+...+.+...++.-+.. ....+++.+....++.+|.... +..+..++.+|+. T Consensus 468 l~~gifp~~~~ll~~-~~~~~~~~l~~iw~kil~~d~~-----~~~~l~~~~~~~~f~~~l~~~~~~~~~~~~~afiLa~ 541 (1392) T 6U62_A 468 LSVGIFPYVLKLLQS-SARELRPLLVFIWAKILAVDSS-----CQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAV 541 (1392) T ss_dssp HHHTCHHHHHHGGGC-CCSTTHHHHHHHHHHHHTTCGG-----GHHHHHHTTTHHHHHHHHHSTTSCSSSHHHHHHHHHH T ss_pred HHcCcHHHHHHHHHc-cchhhHHHHHHHHHHHHhhCch-----hHHHHHhccchHHHHHhhcCCCCChhHHHHHHHHHHH Confidence 466778888888873 4445554445555555443221 1222234444555666665432 2244566667777 Q NP_000290.2 622 MSRH-PLLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. .... .....+++..+...|.. .++.++..++-+|+.|....+..+...+..+....|..++.+. .++ T Consensus 542 ~~~~~~~~q~~~~~~~~~~~~~~~l~~------~~~~~r~W~~l~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~d~-~pe 614 (1392) T 6U62_A 542 IVNSYHTGQEACLQGNLIAICLEQLND------PHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDP-IPE 614 (1392) T ss_dssp HSTTCHHHHHHHHHTTHHHHHHTSTTC------SCHHHHHHHHHHHHHHSSSCHHHHHHHHTTTHHHHSGGGGGCS-STT T ss_pred HHhhCcchHHHHHhchHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHHHHhhcccHHHHHHHHhcCC-CHH Confidence 7754 2222 22233455666666654 3688899999999999876555555555555667788888877 899 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ||.+|+.+|+.++... T Consensus 615 VRaaav~aL~~~i~~~ 630 (1392) T 6U62_A 615 VRCAAVFALGTFVGNS 630 (1392) T ss_dssp HHHHHHHHHHHHSCCT T ss_pred HHHHHHHHHHHhhCCC Confidence 9999999998887553 No 380 >6BCX_W mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP; 3.0A {Homo sapiens} Probab=82.82 E-value=0.098 Score=62.11 Aligned_cols=159 Identities=10% Similarity=0.013 Sum_probs=98.0 Template_Neff=7.900 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSN 621 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsn 621 (747) ...|+++.++++|++ ...+.+...+.+...++.-+.. ....+++.+....++.+|.... +..+..++.+|+. T Consensus 476 l~~gifp~~~~ll~~-~~~~~~~~l~~iw~kil~~d~~-----~~~~l~~~~~~~~f~~~l~~~~~~~~~~~~~a~iLa~ 549 (1343) T 6BCX_W 476 LSVGIFPYVLKLLQS-SARELRPLLVFIWAKILAVDSS-----CQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAV 549 (1343) T ss_dssp HHHTCHHHHHHGGGC-CCGGGHHHHHHHHHHHHHHCGG-----GHHHHHHTTHHHHHHHHHTCTTSCHHHHHHHHHHHHH T ss_pred HHcCcHHHHHHHHHc-cchhhHHHHHHHHHHHHhhCcc-----hHHHHHhccchhHHHHhhcCCCCChhHHHHHHHHHHH Confidence 356778888888873 4444544444455555443221 1222234444555666665432 2234566667777 Q NP_000290.2 622 MSRH-PLLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. .... .....+++..+...|.. .++.++..++-+|+.|....+..+...+..+....+..++.+. .++ T Consensus 550 ~~~~~~~~q~~~~~~~~~~~~~~~l~~------~~~~~r~W~~l~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~d~-~pe 622 (1343) T 6BCX_W 550 IVNSYHTGQEACLQGNLIAICLEQLND------PHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDP-IPE 622 (1343) T ss_dssp HSTTCHHHHHHHHHTTHHHHHHHTTTC------SCHHHHHHHHHHHHHHTTTCHHHHHHHHHHTHHHHHGGGGGCS-SHH T ss_pred HHhhCchhHHHHHhchHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHHHHhhcccHHHHHHHHhcCC-CHH Confidence 7654 2222 22333456666666654 3688899999999999876555555555555667788888877 899 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ||.+++.+|+.++... T Consensus 623 vRaa~v~aL~~~i~~~ 638 (1343) T 6BCX_W 623 VRCAAVFALGTFVGNS 638 (1343) T ss_dssp HHHHHHHHHHHHHTTC T ss_pred HHHHHHHHHHHhhCCC Confidence 9999999998887653 No 381 >4QMH_A LP04448p; PROTEIN BINDING, TOG DOMAIN; 1.652A {Drosophila melanogaster} Probab=82.76 E-value=0.081 Score=45.96 Aligned_cols=114 Identities=8% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.700 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .+++.+...+.+.++.++..++.+|..+.............+++.+...+.+ .++.++..++.++..++..... T Consensus 17 ~l~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~l~~~l~d------~~~~v~~~a~~~l~~l~~~~~~ 90 (241) T 4QMH_A 17 QITEALLKEMSDKDWKTRNEGLTKLQAIISEARLIKPSIGDLAPALAHRLVD------SNAKIAQTTLAICEQLATAMGA 90 (241) T ss_dssp GSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHCSBCSCCTTHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHGG T ss_pred HhhHHHHHhcCCccHHHHHHHHHHHHHHHHhCCcCcccHHHHHHHHHHHHcC------CCHHHHHHHHHHHHHHHHHhcH Confidence 3455566666677778888888888888764211110112345555666655 3678888888888888764322 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ...... ..+++.+...+.+. +..++..++.+|..+..... T Consensus 91 ~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~~ 130 (241) T 4QMH_A 91 GCRNHV-RNLFPGFLHALGDN-KSFVRAAALNCINSFGEKGG 130 (241) T ss_dssp GGGGGH-HHHHHHHHHHTTCS-SHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHH-HHHHHHHHHHhcCC-cHHHHHHHHHHHHHHHHhcC Confidence 111111 23455666666554 55677777777777665443 No 382 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=82.76 E-value=0.083 Score=54.05 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=92.9 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.+..++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (621) T 6QH5_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (621) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHHhhcCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHHH Confidence 4556667776 46677888888888887653221 1 12355666777777788899999999888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (621) T 6QH5_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (621) T ss_pred -----HHHHHHHHHHHhcCCC------CCHHHHHHHHHHHHHHHHhChHH---ccHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 112445555666 44 36788999999999887642221 11234567777777766 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~L~~l~~ 216 (621) T 6QH5_A 209 SLITTLAQ 216 (621) T ss_pred HHHHHHHH Confidence 88888775 No 383 >6EMK_C Serine/threonine-protein kinase TOR2 (E.C.2.7.1.67,2.7.11.1), Target; target of rapamycin, torc2, FRB; 8.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=82.75 E-value=0.086 Score=64.86 Aligned_cols=71 Identities=13% Similarity=0.124 Sum_probs=44.6 Template_Neff=11.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLE-ACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~-~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.|+..+. +.+..++. .++.+|..++..... ....+ -..+++.+...+.+.+..++..++.+|..++.. T Consensus 922 ~~~~L~~~l~-d~~~~v~~~~a~~~L~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~~~~~L~~l~~~ 993 (2474) T 6EMK_C 922 VIHNLMKILN-DPSLSIHHTAAIQAIMHIFQNLGL-----RCVSF-LDQIIPGIILVMRSCPPSQLDFYFQQLGSLISI 993 (2474) T ss_dssp TTCCCCCCTT-CCCCCCCCCCCTTTCCCCCCCCCC-----CCCCC-SSTTCCCCCCCCCCCCHHHHCCCCCCTTTCCCC T ss_pred HHHHHHHHHc-CCchHHHHHHHHHHHHHHHHHcch-----hhHHh-HhhHHHHHHHHHhhCCHHHHHHHHHHHHHHHHH Confidence 4566667776 34555555 778888887764221 01111 134566677777666677888888888888764 No 384 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=82.68 E-value=0.082 Score=49.28 Aligned_cols=71 Identities=11% Similarity=-0.055 Sum_probs=38.3 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLM-GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 548 ~I~~LL~LL-~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) .++.++..+ . ++++.++..++.+|..+...... . .... .....++.+...+.+.++.++..++.+|..+.. T Consensus 39 ~~~~l~~~l~~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~ 110 (373) T 5MU7_A 39 LLMHIIRFVMP-SKSKPLKKLLYFYYEICPKLDSQ---G-KLKQ-EFILVCNGIRNDLQHPNEYIRGNTLRFLCKLRE 110 (373) T ss_dssp GHHHHHHHTTT-CCCHHHHHHHHHHHHHSCCBCTT---S-CBCT-HHHHHHHHHHHHTTCSSHHHHHHHHHHHTTCCC T ss_pred HHHHHHHHHcC-CCChhhHHHHHHHHHhccccCCc---c-hHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHhccC Confidence 345555553 4 35666777777777776542111 0 0000 012345556666666666777777777766543 No 385 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=82.65 E-value=0.081 Score=52.06 Aligned_cols=145 Identities=12% Similarity=0.047 Sum_probs=93.3 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..+...... .....++++.+...+.+.++.++..++.+|..+.... T Consensus 109 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 179 (570) T 6CRI_I 109 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------LVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHP 179 (570) T ss_dssp SHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHCHH--------HHHHHTHHHHHHHHHTSSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHhcC-CCCHHHHHHHHHHHHHHHHhChh--------hhhccchHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCC Confidence 4556667776 46778888999999988764321 1112456778888888888899999999999888652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ........+++.+...+.+ .++.++..++.+|..+....... ....++.+...+.+. ++.++..++ T Consensus 180 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 247 (570) T 6CRI_I 180 SSNLLDLNPQSINKLLTALNE------CTEWGQIFILDCLANYMPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 247 (570) T ss_dssp STTCCCCCHHHHHHHHHHHTT------SCHHHHHHHHHHTTTCCCSSHHH-----HHHHHHHHGGGGGBS-CHHHHHHHH T ss_pred CcchhccCHHHHHHHHHHhhc------CCHHHHHHHHHHHHHhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111112355555555554 25677778888888877542211 112455556666655 677788888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 248 ~~l~~l~~ 255 (570) T 6CRI_I 248 KVLMKFME 255 (570) T ss_dssp HHHHHHTT T ss_pred HHHHHHHH Confidence 87777764 No 386 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=82.55 E-value=0.084 Score=45.96 Aligned_cols=112 Identities=11% Similarity=0.091 Sum_probs=68.9 Template_Neff=12.600 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) .+++.+...+.+.++.++..++.++..+...... ...+ ..+++.+...+.+ .++.++..++.++..++...+ T Consensus 19 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~-~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 91 (240) T 4QMI_B 19 KITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNI-GELPTALKGRLND------SNKILVQQTLNILQQLAVAMG 91 (240) T ss_dssp GSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHCSBCSCC-TTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHG T ss_pred hccHHHHHHhcCCCHHHHHHHHHHHHHHHcCchHhccch-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhc Confidence 3455666667777788888888888888765211 1111 2345556666655 367888888888888876532 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....... ...++.++..+.+. +..++..++.++..+.... T Consensus 92 ~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~ 131 (240) T 4QMI_B 92 PNIKQHV-KNLGIPIITVLGDS-KNNVRAAALATVNAWAEQT 131 (240) T ss_dssp GGGGGGC-CCCCHHHHHHTTCS-SHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHH-HHHHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHh Confidence 2111111 23456666666655 5667777777777776553 No 387 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=82.55 E-value=0.084 Score=45.96 Aligned_cols=112 Identities=11% Similarity=0.091 Sum_probs=68.9 Template_Neff=12.600 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) .+++.+...+.+.++.++..++.++..+...... ...+ ..+++.+...+.+ .++.++..++.++..++...+ T Consensus 19 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~-~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 91 (240) T 4QMJ_A 19 KITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNI-GELPTALKGRLND------SNKILVQQTLNILQQLAVAMG 91 (240) T ss_dssp TSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHSSBCSCC-TTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHG T ss_pred hccHHHHHHhcCCCHHHHHHHHHHHHHHHcCchHhccch-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhc Confidence 3455666667777788888888888888765211 1111 2345556666655 367888888888888876532 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....... ...++.++..+.+. +..++..++.++..+.... T Consensus 92 ~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~ 131 (240) T 4QMJ_A 92 PNIKQHV-KNLGIPIITVLGDS-KNNVRAAALATVNAWAEQT 131 (240) T ss_dssp GGGGGGC-CCCCHHHHHGGGCS-SHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHH-HHHHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHh Confidence 2111111 23456666666655 5667777777777776553 No 388 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=82.53 E-value=0.084 Score=52.43 Aligned_cols=147 Identities=12% Similarity=0.077 Sum_probs=92.8 Template_Neff=12.700 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.+...+. +.++.++..++..|..++..... . .. .. .-..+++.+...+ .+.++.++..++.++..++.. T Consensus 315 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~~~-~~~~i~~~l~~~l~~d~~~~v~~~a~~~l~~l~~~ 388 (554) T 6MZG_E 315 PADFQTRIS-STKWKDRVEALEEIHNNVLKPVK---K-LAHKNQ-DYSDYLRVLANVIQKDANVQAVTIAANSVQLLCNS 388 (554) T ss_dssp CSTTTTTTT-CSCHHHHHHHHHHCCCCCCTTCS---C-BCCSSC-CTHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHhc-CCCHHHHHHHHHHHHHhhhcchh---H-HhccCC-cHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHH Confidence 344666666 46677888899999888764221 0 00 01 1135677777777 777888999999999988865 Q NP_000290.2 626 P-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 ~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) . .. .......+++.+...+.+ .+..++..++.+|..++.... ...+++.+...+.+. ++.++.. T Consensus 389 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~-~~~vr~~ 454 (554) T 6MZG_E 389 LRSNFTRSYGAIVLVPLLERTKE------KKPSVNEAICSALDAVATYCG-------FDDCLEETLNYMKHK-TPQVRIE 454 (554) T ss_dssp STTCCSSHHHHHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTSS-------SSSHHHHHHHHHTCS-CHHHHHH T ss_pred hhccccHHHHHhhHHHHHHHhhh------ccHHHHHHHHHHHHHHHHHcC-------HHHHHHHHHHHhcCC-CHHHHHH Confidence 1 11 101112356666666655 256788888888888876421 123455666666554 6778888 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|..++... T Consensus 455 ~~~~l~~l~~~~ 466 (554) T 6MZG_E 455 CTKFLTRMLQGW 466 (554) T ss_dssp HHHHHHHHHHTC T ss_pred HHHHHHHHHccC Confidence 888888776543 No 389 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=82.32 E-value=0.085 Score=51.84 Aligned_cols=147 Identities=13% Similarity=0.119 Sum_probs=94.4 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.+|..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 164 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~ 234 (588) T 1B3U_A 164 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL-------DN-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 234 (588) T ss_dssp HHHHHHHHHHT-CSCHHHHHHHHHHHHHHHHTSCH-------HH-CCCCCHHHHHHHHTCSCHHHHTTHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHcCh-------hh-hhhhhHHHHHHHhcCCCHHHHHHHHHHHHHHHHhC Confidence 35566667776 46778888898888888763221 11 12456677777777778888999999888887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+..++.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 235 ~~~-~~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~-~~~~r~~a~~ 303 (588) T 1B3U_A 235 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 303 (588) T ss_dssp CHH-HHHHHTHHHHHHHHTC------SSHHHHHHHHHTHHHHHHHHCH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHH T ss_pred CHH-HHHHHHHHHHHHHHhC------CCHHHHHHHHhhHHHHHHHHCC---CCCHHhHHHHHHHHhccC-HHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111224566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 304 ~l~~l~~ 310 (588) T 1B3U_A 304 KVKEFCE 310 (588) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8877765 No 390 >2OF3_A ZYG-9; Multifunctional macromolecule, Kinetochore, microtubule, XMAP215; 1.9A {Caenorhabditis elegans} Probab=81.96 E-value=0.098 Score=48.11 Aligned_cols=150 Identities=9% Similarity=-0.036 Sum_probs=91.9 Template_Neff=11.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .........-..+++.++..+.+.+..++..+..+|..+..... T Consensus 88 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~ll~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 164 (266) T 2OF3_A 88 LLKWCTLRFF-ETNPAALIKVLELCKVIVELIRD--TETPMSQEEVSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVG 164 (266) T ss_dssp HHHHHHHHTT-SCCHHHHHHHHHHHHHHHHHHHH--TTCCCCHHHHHHHHHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHHHh--CCCCCCHHHHHhHHHHHHHHhCCCcHHHHHHHHHHHHHHHHhhC Confidence 3455555666 46677888888888888764221 00000000013456677777777777788888888887765421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..+........... ..+++.+...+.+. ++.++..++.+ T Consensus 165 ~-----~~~~~~l~~~l~~------~~~~~r~~~l~~l~~~~~~~~~~~~~~--~~ii~~l~~~l~d~-~~~VR~~a~~~ 230 (266) T 2OF3_A 165 P-----LKMTPMLLDALKS------KNARQRSECLLVIEYYITNAGISPLKS--LSVEKTVAPFVGDK-DVNVRNAAINV 230 (266) T ss_dssp H-----HHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHCSGGGGG--GCHHHHHGGGGGCS-SHHHHHHHHHH T ss_pred H-----HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCccccc--ChHHHHHHHHHcCC-CHHHHHHHHHH Confidence 1 1234445555544 357778888888888775432211111 34667777777766 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (266) T 2OF3_A 231 LVACFKF 237 (266) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8888754 No 391 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=81.77 E-value=0.092 Score=51.50 Aligned_cols=147 Identities=13% Similarity=0.130 Sum_probs=94.5 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.+|..+...... . . ....+++.+...+.+.++.++..++.++..+.... T Consensus 160 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~ 230 (584) T 4I5L_D 160 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL------D-N-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 230 (584) T ss_dssp HHHHHHHHHHT-CSSHHHHHHHHHHHHHHHTTSCH------H-H-CCCCCHHHHHHHTTCSCHHHHTTHHHHHHHHHHHS T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHcCh------h-h-hhcchHHHHHHHhCCCCHHHHHHHHHHHHHHHHhC Confidence 34566667776 46778888899888888764221 1 1 12456677777787778888999999988887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+..++.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 231 ~~~-~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 299 (584) T 4I5L_D 231 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 299 (584) T ss_dssp CTT-THHHHTHHHHHHHHTC------SSHHHHHHHHHTHHHHHHHHHH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHT T ss_pred CHH-HHHHHHHHHHHHHhhC------CCHHHHHHHHHHHHHHHHHHCC---CCChhhHHHHHHHHhcCC-cHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111224566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 300 ~l~~l~~ 306 (584) T 4I5L_D 300 KVKEFCE 306 (584) T ss_dssp THHHHHH T ss_pred HHHHHHH Confidence 8887765 No 392 >4Y5J_A Mini spindles TOG3; XMAP215, TOG, microtubule polymerization; 2.303A {Drosophila melanogaster} Probab=81.72 E-value=0.097 Score=46.19 Aligned_cols=71 Identities=13% Similarity=0.043 Sum_probs=45.8 Template_Neff=12.300 Q NP_000290.2 548 AIRT-YLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIA---RLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~-LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll---~LL~s~d~eVr~~AL~aLsnLa 623 (747) .++. ++..+. +.++.++..++..|..++..... .... ....+++.+. ..+.+.++.++..++.++..++ T Consensus 15 ~l~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~-----~~~~-~~~~l~~~l~~l~~~l~d~~~~v~~~a~~~l~~l~ 87 (248) T 4Y5J_A 15 ILPAEILNGLV-DSNWKNRLAAVEQLLGEISGFDA-----KQAG-ISQILIRTISGRKPGLKEMNFQVLKFKLDIIRSVA 87 (248) T ss_dssp CCCHHHHHHHH-CSSHHHHHHHHHHHHHHGGGSCT-----TSTT-HHHHHHHHHHSSSSGGGCSSHHHHHHHHHHHHHHH T ss_pred hcCHHHHHhhc-CcCHHHHHHHHHHHHHHHccCch-----hccc-hHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHH Confidence 4555 777776 46778888899999888764221 0111 1123444444 5666667788888888888887 Q NP_000290.2 624 RH 625 (747) Q Consensus 624 ~~ 625 (747) .. T Consensus 88 ~~ 89 (248) T 4Y5J_A 88 EN 89 (248) T ss_dssp HH T ss_pred Hh Confidence 54 No 393 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=81.57 E-value=0.1 Score=53.70 Aligned_cols=137 Identities=17% Similarity=0.119 Sum_probs=87.9 Template_Neff=12.000 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +..++.++. +.+..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 81 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~- 148 (627) T 4P6Z_G 81 QLECLKLIA-SQKFTDKRIGYLGAMLLLDERQD--------V--HLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEM- 148 (627) T ss_dssp HHHHHHHHT-SSSHHHHHHHHHHHHHHCCTTSC--------C--HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHCCHHH- T ss_pred HHHHHHHHc-CCCCchhHHHHHHHHHHCCCChH--------H--HHHHHHHHHHHhhCCCHHHHHHHHHHHHhcCCHHH- Confidence 344556666 46677777888888777653221 1 12345566666777778888888888887764211 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ...+++.+..++.+ .++.++..++.+|..+....+... ..+++.|...+.+. ++.++..++.++ T Consensus 149 ----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~l 212 (627) T 4P6Z_G 149 ----CRDLAGEVEKLLKT------SNSYLRKKAALCAVHVIRKVPELM-----EMFLPATKNLLNEK-NHGVLHTSVVLL 212 (627) T ss_dssp ----HHHHHHHHHHHHTC------SCHHHHHHHHHHHHHHHHHCSGGG-----GGGHHHHTTCTTCC-CHHHHHHHHHHH T ss_pred ----HHHHHHHHHHHhhC------CCHHHHHHHHHHHHHHHHHCHHHH-----HHHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 12345666666665 367888889999988876433221 24566677777655 677888888888 Q NP_000290.2 709 SDMWS 713 (747) Q Consensus 709 snL~~ 713 (747) ..+.. T Consensus 213 ~~~~~ 217 (627) T 4P6Z_G 213 TEMCE 217 (627) T ss_dssp HHHHH T ss_pred HHHHH Confidence 77754 No 394 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=81.46 E-value=0.11 Score=61.49 Aligned_cols=126 Identities=13% Similarity=0.064 Sum_probs=72.5 Template_Neff=9.500 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.|..++.+.++.++..++.+|..+.... ....+.. ..++.|+.++.+.++.++..++.+|..+..........+. T Consensus 621 l~~L~~~l~d~~~~vR~~a~~al~~l~~~~--~~~~~~~-~~lp~L~~lL~d~~~~vr~~al~aL~~L~~~~~~~~~~~~ 697 (1454) T 5KC2_B 621 LSHLITYLNDKDPALRVSLIQTISGISILL--GTVTLEQ-YILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYI 697 (1454) T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHHhh--HHHHHHH-cCHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHHH Confidence 444555555566667777777776666432 1112222 2266777777776777788888888877653322222221 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRV 379 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL 379 (747) ..++.+..++. +.++.++..+..+|..|+...... .....+++.|+.+| T Consensus 698 --~~l~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~~-~~~~~~~~~L~~~L 746 (1454) T 5KC2_B 698 --DISKTTSPLLL-HPNNWIRQFTLMIIIEIINKLSKA-EVYCILYPIIRPFF 746 (1454) T ss_pred --HHHHHHHHHHC-CCCHHHHHHHHHHHHHHhcCCCCH-HHHcChHHHHHHHh Confidence 25556666665 457778888888888877643221 11134555555555 No 395 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=81.15 E-value=0.1 Score=51.71 Aligned_cols=151 Identities=11% Similarity=0.102 Sum_probs=93.6 Template_Neff=12.700 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +.+...+. +.++.++..++.+|..++..... ........ ....+++.++. ++.+.++.++..++.+|..++..... T Consensus 57 ~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~-~~~~~l~~l~~~~~~~~~~~vr~~a~~~L~~l~~~~~~ 133 (554) T 6MZG_E 57 ELFASYIV-DSNVVAQENAIIALHTLLEYISQ-VPNVSTSK-LRLQWIPPLVEKGLSSSRAATKAKATDCIMLLTQSDTS 133 (554) T ss_dssp HHHHHHTT-CSSHHHHHHHHHHHHHHHHHTCS-SSCCTHHH-HHHHHHHHHCCCCCSCSCHHHHHHHHHHHHHHHHTSSS T ss_pred HHHHHhcC-CccHHHHHHHHHHHHHHHHHHhc-CCCCCcHH-HHHhcHHHHHHHhccCCcHHHHHHHHHHHHHHHhcccc Confidence 55666776 47788899999999988764221 00000001 11345666666 45666788889999999888754111 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK---QYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~---~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+.+ .++.++..++.+|..++........ ......+++.+...+.+. ++.++..++ T Consensus 134 ----~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~~~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~vr~~a~ 202 (554) T 6MZG_E 134 ----IQQTVNLMLPSLSN------KLPRLVSSCVKCLATIIEEFGFINVSDINILLSEILEPLPKLSSHA-DRNVRSETM 202 (554) T ss_dssp ----SHHHHHHHSGGGGC------SCHHHHHHHHHHHHHHHHHTCSCSCSCHHHHHHHHHSSHHHHTTCS-SHHHHHHHH T ss_pred ----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCCccccccccHHHHHHHHHHHhhcC-CHHHHHHHH Confidence 11244555555554 3677888899999888764221110 001234567777777766 788999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 203 ~~l~~l~~~ 211 (554) T 6MZG_E 203 NLILQIYKW 211 (554) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 998888754 No 396 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=81.14 E-value=0.1 Score=51.20 Aligned_cols=108 Identities=11% Similarity=0.069 Sum_probs=63.0 Template_Neff=12.900 Q NP_000290.2 600 IARLLQSGNSDVVRSGASLLSNMSRHPL-LHR---VMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 600 Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~~~---ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) +...+.+.+..++..++.+|..++.... ... .....+++.+...+ .+ .++.++..++.++..++..... T Consensus 300 l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~d------~~~~v~~~a~~~l~~l~~~~~~ 373 (536) T 6MZE_Z 300 FQTRISSTKWKDRVEALEEIHNNVLKPVKKLAHKNQDYSDYLRVLANVIQKD------ANVQAVTIAANSVQLLCNSLRS 373 (536) T ss_dssp GHHHHSCSSHHHHHHHHHHCCCCCCSSCSCBCCTTCCCTTTHHHHHHHHHHC------SCHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHhhcCCHHHHHHHHHHHHHHhhccchhhccCCCCHHHHHHHHHHHHhcC------chHHHHHHHHHHHHHHHHHccc Confidence 4455555667778888888888775411 100 11123556666666 54 3678888899999888764322 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .........+++.++..+.+. +..++..++.+|..++.. T Consensus 374 ~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 412 (536) T 6MZE_Z 374 NFTRSYGAIVLVPLLERTKEK-KPSVNEAICSALDAVATY 412 (536) T ss_dssp CCSSHHHHHHHHHHHHHTTCC-CHHHHHHHHHHHHHHHHT T ss_pred cccHHHHHHHHHHHHHHhhcc-CHHHHHHHHHHHHHHHHh Confidence 111011123455666666554 566777777777776654 No 397 >6RXU_UJ Periodic tryptophan protein 2-like protein; ribosome, ribosome biogenesis, rRNA; HET: GTP; 3.5A {Chaetomium thermophilum} Probab=80.93 E-value=0.12 Score=62.49 Aligned_cols=152 Identities=9% Similarity=0.051 Sum_probs=85.8 Template_Neff=9.700 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLLQSG--------NSDVV 612 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL~s~--------d~eVr 612 (747) +++.++..+... .+..++..++.+|..++..... .... .. -..+++.|...+... ...++ T Consensus 1625 il~~ll~~L~~~~~~~~~~~~v~~~~l~~L~~l~~~~~~---~~~~~~~~--~~~ll~~L~~~L~~~~~~~~~~~~~~v~ 1699 (1802) T 6RXU_UJ 1625 IVDASVKALKAVDFAVPEERNLWKRVLCTLAKCFEHDQD---GFWQAPAH--FGAVAPVLVEQFLRAEGQVTATNVNDVI 1699 (1802) T ss_pred HHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHHHhCh---hhhcChhH--HHHHHHHHHHHHhCCCCCCCccccHHHH Confidence 345555555521 2456777788888877764221 0000 11 134556666666532 23567 Q NP_000290.2 613 RSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) ..++.+++.++.......+. ..+++.++..+.+ .++.++..++.++..++.........+. ..+++.+...+ T Consensus 1700 ~~ai~~L~~l~~~~~~~~~~-~~l~~~ll~~l~~------~~~~vR~~al~~L~~l~~~~g~~~~~~l-~~ii~~L~elL 1771 (1802) T 6RXU_UJ 1700 QDVVPAVVELAAAVESQEHY-KEINTALLKHLRN------GSPGVRLAVVKCQQAITAKLGEDWLHLL-PEMLPYISELQ 1771 (1802) T ss_pred HHHHHHHHHHHHHhCCchHH-HhHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHHcHhhHHhH-HHHHHHHHHHh Confidence 77888888877531111111 1234445555544 3567888999999988765332222222 24567777777 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++. ++.++..+..++..+.. T Consensus 1772 eD~-d~~V~~~a~~~l~~l~~ 1791 (1802) T 6RXU_UJ 1772 DDD-DEVVERENRRWIVGIEE 1791 (1802) T ss_pred cCC-CHHHHHHHHHHHHHHHH Confidence 766 77788888777776654 No 398 >5FVM_B SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF; TRANSFERASE, CRYO-EM, TOR, LST8, MTOR; 6.7A {KLUYVEROMYCES MARXIANUS} Probab=80.75 E-value=0.12 Score=63.47 Aligned_cols=147 Identities=12% Similarity=0.092 Sum_probs=75.7 Template_Neff=11.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. + ..++..++.++..++..... ....+ -..+++.++..+.+.+..++..++.++..+..... T Consensus 1008 i~~~l~~~l~-~--~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~ll~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~ 1078 (2471) T 5FVM_B 1008 IVDVISEFFP-V--LKLQLTIISVIESLSRALEG-----EFNPH-LPTILSLFLDVLEKDQSNKKVVSVRILKSLVVFGP 1078 (2471) T ss_dssp HHHTTC------------CTHHHHHHHHHTTSSC-----CHHHH-HHHHHHHHHHHHC----CCHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHcc-c--hhHHHHHHHHHHHHHHHccc-----ChHHH-HHHHHHHHHHHHccCCCCcHHHHHHHHHHHHHHhh Confidence 3444555444 1 45666778888877754221 01111 23566777777776666677777777776654321 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . ...+ ..+++.+...+.+ .++.++..++.+|..++..... .. ....++..++..+.+. ++.++..++. T Consensus 1079 ~~~~~l-~~il~~l~~~l~~------~~~~vr~~al~~l~~l~~~~~~--~~-~~~~i~~~l~~~l~~~-~~~vr~~a~~ 1147 (2471) T 5FVM_B 1079 HLEEYV-HLVLPTIIKLSEF------SSGNLKKAAIITIGRLSKNVNA--LE-MSSRIVQALVRVLNTS-ETEYVKATMN 1147 (2471) T ss_dssp SCCCHH-HHHHHHHHTTC---------CCHHHHHHHHHHHHHHHC-CC--HH-HHHHHHHHHHHHCC---CTHHHHHHHH T ss_pred hHHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCCh--HH-HHHHHHHHHHHHHcCC-ChHHHHHHHH Confidence 1 1111 2355666666655 2567888888888888754221 11 1124566666777655 6677888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 1148 ~l~~l~~~ 1155 (2471) T 5FVM_B 1148 TLSLLLLQ 1155 (2471) T ss_dssp HHHHHHHC T ss_pred HHHHHHHH Confidence 88777643 No 399 >6GWC_C Tubulin alpha chain, Tubulin beta; microtubule, ARTIFICIAL PROTEIN, ALPHAREP, cytoskeleton; HET: GTP, MES, PGE; 2.6A {Ovis aries} Probab=80.69 E-value=0.11 Score=45.32 Aligned_cols=49 Identities=8% Similarity=0.093 Sum_probs=29.6 Template_Neff=12.200 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|..+... ..++.+..++.+. ++.++..++.++..+... T Consensus 120 ~~~~r~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 168 (232) T 6GWC_C 120 DTTVRRIAATALGKIGDE-----------RAVEPLIKALKDE-DAAVRLTAARALGEIGDE 168 (232) T ss_pred CHHHHHHHHHHHHHhccc-----------chHHHHHHHhcCC-CHHHHHHHHHHHHHhCCh Confidence 455556666666555321 2344455566655 677888888888877653 No 400 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=80.56 E-value=0.11 Score=46.13 Aligned_cols=64 Identities=13% Similarity=0.063 Sum_probs=32.1 Template_Neff=12.700 Q NP_000290.2 549 IRTYLN-LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 549 I~~LL~-LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ++.+.. ++. +.++.++..++.+|..+....+. .....++.+...+.+.++.++..++.+|..+. T Consensus 92 ~~~l~~~~l~-~~~~~vr~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 156 (280) T 1OYZ_A 92 FNILNNMALN-DKSACVRATAIESTAQRCKKNPI----------YSPKIVEQSQITAFDKSTNVRRATAFAISVIN 156 (280) T ss_dssp HHHHHHHHHH-CSCHHHHHHHHHHHHHHHHHCGG----------GHHHHHHHHHHHTTCSCHHHHHHHHHHHHTC- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCcc----------cChhHHHHHHHHhcCCCHHHHHHHHHHHHhhc Confidence 344444 444 34556666666666665532110 11233445555555555666666666665544 No 401 >6GX7_F Tubulin alpha chain, Tubulin beta; microtubule, ALPHAREP, CELL CYCLE, COPN; HET: MES, PGE, SO4, GOL, GTP; 3.19A {Ovis aries} Probab=80.46 E-value=0.12 Score=44.09 Aligned_cols=122 Identities=14% Similarity=0.214 Sum_probs=55.9 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++..+..+.. ...++.+..++.+.++.++..++.++..+... T Consensus 46 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 106 (201) T 6GX7_F 46 AVEPLIKALK-DEDPWVRREAAGALGQIGD----------------ERAVEPLIKALKDEDRYVRRIAARALGKIGDE-- 106 (201) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHTC----------------GGGHHHHHHHTTCSSHHHHHHHHHHHHHHTCG-- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCh-- Confidence 3444555554 2445555555555544321 11233344445555555666666666555421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... ..++.+..++.+. +..++..++.+ T Consensus 107 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 161 (201) T 6GX7_F 107 -------RAVEPLIKALKD------EDWQVREDAAKALGQIGDE-----------RAVEPLIKALKDE-DTTVRLEAALA 161 (201) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHTCG-----------GGHHHHHHHTTCS-SHHHHHHHHHH T ss_pred -------hhHHHHHHHhhc------CCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHHhCC-CHHHHHHHHHH Confidence 122333333433 2345555555555554321 1233333444433 45555566666 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) +..+.. T Consensus 162 l~~~~~ 167 (201) T 6GX7_F 162 LGKIGG 167 (201) T ss_dssp HHHHCS T ss_pred HHhhcc Confidence 555543 No 402 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=80.40 E-value=0.11 Score=50.67 Aligned_cols=147 Identities=13% Similarity=0.119 Sum_probs=93.6 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 158 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~~~~~~~~~r~~a~~~l~~l~~~~ 228 (582) T 2NYL_A 158 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL-------DN-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 228 (582) T ss_dssp HHHHHHHHHHS-CSCHHHHHHHHHHHHHHHTTSCH-------HH-CCCCCHHHHHHHTSCSCHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHcCh-------hh-hHhhHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHC Confidence 35566667776 46778888899988888763221 11 12456677777777777888888988888887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+...+.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 229 ~~~-~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~-~~~v~~~a~~ 297 (582) T 2NYL_A 229 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 297 (582) T ss_dssp CHH-HHTTTTHHHHHHHHHC------SSHHHHHHHHHTHHHHHHHHCS---HHCCCCCHHHHHHHHTCS-SHHHHHHHHT T ss_pred CHH-HHHHHHHHHHHHHhcC------CCHHHHHHHHHhHHHHHHHHCC---CCCHhhhHHHHHHHhcCC-hHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111223566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 298 ~l~~~~~ 304 (582) T 2NYL_A 298 KVKEFCE 304 (582) T ss_dssp THHHHHH T ss_pred HHHHHHH Confidence 8877765 No 403 >5VJC_B Protein mini spindles; TOG, HEAT Repeat, Tubulin, CELL; 2.0A {Drosophila melanogaster} Probab=80.32 E-value=0.12 Score=47.18 Aligned_cols=72 Identities=13% Similarity=0.027 Sum_probs=44.4 Template_Neff=11.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.+.+...+. +.++.++..++..|..++..... ...... ..++..+...+.+.++.++..++.++..++.. T Consensus 50 ~~~~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~~-~~l~~~l~~~l~d~~~~vr~~a~~~l~~l~~~ 121 (271) T 5VJC_B 50 NVNKALIANMF-HDDFRYHLKVIEQLSEDLAGNSK-----ALVCNL-DLILKWLTLRFYDTNPSVLIKGLEYLVQVFQV 121 (271) T ss_dssp TCCHHHHHHHT-CSCHHHHHHHHHHHHHHTTTCHH-----HHHHTH-HHHHHHHHHHTTSSCHHHHHHHHHHHHHHHHH T ss_pred cCCHHHHHhcc-CCCHHHHHHHHHHHHHHHhcCHH-----HHHHHH-HHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHH Confidence 34566777776 46777888888888888764321 011111 23344455555566777888888888877654 No 404 >6RXV_UJ Periodic tryptophan protein 2-like protein; ribosome, ribosome biogenesis, rRNA; HET: GTP; 4.0A {Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)} Probab=80.28 E-value=0.13 Score=62.13 Aligned_cols=152 Identities=9% Similarity=0.051 Sum_probs=86.0 Template_Neff=9.700 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLLQSG--------NSDVV 612 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL~s~--------d~eVr 612 (747) +++.++..+... .+..++..++.+|..++..... .... .. -..+++.|...+... ...++ T Consensus 1625 il~~ll~~L~~~~~~~~~~~~v~~~al~~L~~l~~~~~~---~~~~~~~~--~~~il~~L~~~L~~~~~~~~~~~~~~v~ 1699 (1802) T 6RXV_UJ 1625 IVDASVKALKAVDFAVPEERNLWKRVLCTLAKCFEHDQD---GFWQAPAH--FGAVAPVLVEQFLRAEGQVTATNVNDVI 1699 (1802) T ss_pred HHHHHHHHHHhcCCCChHHHHHHHHHHHHHHHHHhcCCC---CcccChhH--HHhHHHHHHHHHHhhcCCCCCccHHHHH Confidence 345555555521 2456777788888877764221 0000 11 134556666666532 23567 Q NP_000290.2 613 RSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) ..++.+++.++.......+. ..+++.++..+.+ .++.++..++.++..++.........+. ..+++.+...+ T Consensus 1700 ~~ai~~L~~l~~~~~~~~~~-~~l~~~ll~~l~~------~~~~vR~~al~~L~~l~~~~g~~~~~~l-~eii~~L~elL 1771 (1802) T 6RXV_UJ 1700 QDVVPAVVELAAAVESQEHY-KEINTALLKHLRN------GSPGVRLAVVKCQQAITAKLGEDWLHLL-PEMLPYISELQ 1771 (1802) T ss_pred HHHHHHHHHHHHHcCCHHHH-HHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHHHCHhHHhhh-hHHHHHHHHHh Confidence 77888888877531111111 1234445555544 3567888999999988765332222222 24567777777 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++. ++.++..+..++..+.. T Consensus 1772 eD~-d~~V~~~a~~~l~~l~~ 1791 (1802) T 6RXV_UJ 1772 DDD-DEVVERENRRWIVGIEE 1791 (1802) T ss_pred cCC-CHHHHHHHHHHHHHHHH Confidence 766 77788888777776654 No 405 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=80.24 E-value=0.11 Score=50.76 Aligned_cols=109 Identities=15% Similarity=0.189 Sum_probs=68.2 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+... T Consensus 238 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 308 (584) T 4I5L_D 238 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 308 (584) T ss_dssp HTHHHHHHHHT-CSSHHHHHHHHHTHHHHHHHHHH-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTS T ss_pred HHHHHHHHHhh-CCCHHHHHHHHHHHHHHHHHHCC-------CC-ChhhHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhc Confidence 35566666776 46778888888888887754221 11 1245667777778777788899999999888764 Q NP_000290.2 626 PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... . ......+++.+...+.+ .+..++..++.++..+.. T Consensus 309 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 349 (584) T 4I5L_D 309 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 349 (584) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHTTGGGGHH T ss_pred CccchhhHHHHhHHHHHHHHccC------CCHHHHHHHHHHHHHHHH Confidence 111 1 11123355555555554 245666777777766654 No 406 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=80.23 E-value=0.12 Score=49.62 Aligned_cols=156 Identities=10% Similarity=0.042 Sum_probs=86.8 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM------------SSGMSQ----LIGLKEKGLPQIARLLQSG----- 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~------------s~~~~~----~llie~giI~~Ll~LL~s~----- 607 (747) ++.+...+. +.++.++..++.++..++...... ...... .. .-..+++.+...+.+. T Consensus 261 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~l~~~l~~~l~~~~~~~~ 338 (462) T 1IBR_B 261 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKG-ALQYLVPILTQTLTKQDENDD 338 (462) T ss_dssp HHHHHHHHH-CSSHHHHHHHHHHHHHHHHHHHHHHHHHCCTTCSSSCSSCCCCCHHHH-HHHHHHHHHHHHTTCCCSSCC T ss_pred HHHHHHHHh-cCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCcchhhHHhHHH-HHHHHHHHHHHhcccCCCCCC Confidence 555666666 356777778888888776531000 000000 00 0123344444444433 Q NP_000290.2 608 --NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSM 684 (747) Q Consensus 608 --d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~gi 684 (747) +..++..+..++..++..... .....+++.+...+.+ .++.++..++.++..++...+. ...... ..+ T Consensus 339 ~~~~~~r~~a~~~l~~l~~~~~~--~~~~~~~~~l~~~l~~------~~~~~r~~al~~l~~l~~~~~~~~~~~~~-~~~ 409 (462) T 1IBR_B 339 DDDWNPCKAAGVCLMLLATCCED--DIVPHVLPFIKEHIKN------PDWRYRDAAVMAFGCILEGPEPSQLKPLV-IQA 409 (462) T ss_dssp TTCCSHHHHHHHHHHHHHHHTTT--THHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHTSSSSCTTTTCTTT-TTH T ss_pred CCCCCHHHHHHHHHHHHHHhccC--ccHHhHHHHHHHhccC------CCHHHHHHHHHHHHHHHhCCCHHHHHHHH-HHH Confidence 445667777777777654111 0111234444455544 3677888999999988764332 111111 235 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ++.+...+.+. ++.++..++.++..++.... T Consensus 410 ~~~l~~~l~d~-~~~vr~~a~~~l~~l~~~~~ 440 (462) T 1IBR_B 410 MPTLIELMKDP-SVVVRDTAAWTVGRICELLP 440 (462) T ss_dssp HHHHHHGGGCS-CHHHHHHHHHHHHHHHHHGG T ss_pred HHHHHHHcCCC-CHHHHHHHHHHHHHHHHhCh Confidence 66677777665 78899999999998876443 No 407 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=80.14 E-value=0.12 Score=50.76 Aligned_cols=109 Identities=15% Similarity=0.181 Sum_probs=67.7 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 242 ~~~~~l~~~l~-~~~~~~r~~~~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~ 312 (588) T 1B3U_A 242 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 312 (588) T ss_dssp HTHHHHHHHHT-CSSHHHHHHHHHTHHHHHHHHCH-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHHh-CCCHHHHHHHHhhHHHHHHHHCC-------CC-CHHhHHHHHHHHhccCHHHHHHHHHHHHHHHHHhC Confidence 35566666776 46777888888888888754221 11 12456677777777777888889999988887641 Q NP_000290.2 627 -LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 627 -e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. . ......+++.+...+.+ .+..++..++.++..+.. T Consensus 313 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 353 (588) T 1B3U_A 313 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 353 (588) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHTTGGGGHH T ss_pred CcchhhhhhHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 11 1 11113345555555554 245666667777666654 No 408 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=80.03 E-value=0.13 Score=52.92 Aligned_cols=67 Identities=18% Similarity=0.165 Sum_probs=48.8 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+..++. +.++.++..++.+|..+....+. . ...+++.|...+.+.++.++..++.++..++.. T Consensus 152 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~ 218 (627) T 4P6Z_G 152 LAGEVEKLLK-TSNSYLRKKAALCAVHVIRKVPE--------L--MEMFLPATKNLLNEKNHGVLHTSVVLLTEMCER 218 (627) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHHHHCSG--------G--GGGGHHHHTTCTTCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHh Confidence 4666777777 46778888899999888764221 1 135677777888777888888898888888654 No 409 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=79.96 E-value=0.12 Score=44.07 Aligned_cols=109 Identities=12% Similarity=0.062 Sum_probs=69.2 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+...... T Consensus 51 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~--- 126 (230) T 5NR4_A 51 GKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSY-VAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAP--- 126 (230) T ss_dssp HHHHHHHHHHHHCSSHHHHHHHHHHHHHHHHHHGGGGGGG-HHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHTSC--- T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHhhHHHHHH-HHHHHHHHHHHhccCCHHHHHHHHHHHHHHHHcCCC--- Confidence 3455666666666778888889999888876543221111 134566666666666677788888888777653210 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. +.++.++..++.++..++.. T Consensus 127 ---~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 159 (230) T 5NR4_A 127 ---PMYIWEQLASGFK-HKNFRSREGVCLCLIETLNI 159 (230) T ss_dssp ---HHHHHHHHGGGGG-CSCHHHHHHHHHHHHHHHHH T ss_pred ---HHHHHHHHHhcCC-CCCHHHHHHHHHHHHHHHHH Confidence 1234555555665 45667888888888877753 No 410 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=79.89 E-value=0.12 Score=54.05 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=92.1 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..++..... . .... ....+++.+...+.+.+ +.++..++.++..++ T Consensus 129 l~~~l~~~l~-~~~~~~~~~~~~~~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (876) T 2P8Q_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCT---T-SSST-THHHHHHHHHHHHCTTCSCHHHHHHHHHHHHHHG T ss_pred HHHHHHHHhh-CCCCCHHHHHHHHHHHHHHHHhcCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 4566666666 344 56777888888877754221 0 0011 12456677777777665 788888999998887 Q NP_000290.2 624 RH-PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~-~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) .. ... . ......+++.+...+.+ .++.++..++.+|..+...............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 2P8Q_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_dssp GGCHHHHTCHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHCGGGTHHHCCCCCHHHHHHHHTCS-SHHH T ss_pred HHchhhccCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhcHHHHHHhhhHHHHHHHHHHhcCC-hHHH Confidence 64 111 1 11122344455555544 3567888899999888764332222112223566666667655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 2P8Q_A 276 ALQGIEFWSNVCDE 289 (876) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888777653 No 411 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=79.88 E-value=0.12 Score=50.59 Aligned_cols=147 Identities=14% Similarity=0.094 Sum_probs=80.2 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.++..+...... .. .....++.+...+.+.++.++..++.++..+.... T Consensus 320 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~~--~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 390 (584) T 4I5L_D 320 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------DN--TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI 390 (584) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHTTGGGGHHHHHH------HH--CCCCCHHHHHHHHTCSCHHHHHHHHTCCHHHHHHS T ss_pred hHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHhCC------cc--hHHHHHHHHHHHhcCCCHHHHHHHHHcHHHHHHHc Confidence 45666666776 35667777888888777653211 11 12345666677777777778888888887776541 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .... ....+++.+...+.+ .+..++..++.++..+....+. ......+++.+..++.+. ++.++..++. T Consensus 391 ~~~~-~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 459 (584) T 4I5L_D 391 GIRQ-LSQSLLPAIVELAED------AKWRVRLAIIEYMPLLAGQLGV---EFFDEKLNSLCMAWLVDH-VYAIREAATS 459 (584) T ss_dssp CHHH-HHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHCH---HHCCCCCHHHHHHHTTCS-SHHHHHHHHH T ss_pred ChHH-HHHhHHHHHHHHHHh------CCHHHHHHHHHHHHHHHHhcCh---HHhHHHHHHHHHHHHcCC-HHHHHHHHHH Confidence 1111 112244445555544 2456666677777666543111 111112344444555444 5556666666 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) +|..+.. T Consensus 460 ~l~~l~~ 466 (584) T 4I5L_D 460 NLKKLVE 466 (584) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 6666554 No 412 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=79.85 E-value=0.12 Score=54.15 Aligned_cols=154 Identities=11% Similarity=0.065 Sum_probs=92.3 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..++..... . .... ....+++.+...+.+.+ +.++..++.+|..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (876) T 1QGR_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_pred HHHHHHHHHc-CCCCCHHHHHHHHHHHHHHHhhCCH---H-HHHH-HHHHHHHHHHHHhcCCCCCHHHHHHHHHHHHHHH Confidence 4556666666 344 56777888888877754221 0 0111 12356677777777655 788888999998887 Q NP_000290.2 624 RHP-LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~-e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ... .. . ......+++.+...+.+ .++.++..++.+|..++..............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~i~~~l~~~~~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 1QGR_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_pred hhCCcccCChHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCHHHhhHhhHHhHHHHHHHHhCCC-CHHH Confidence 652 11 1 11122344455555544 3577888899999888765332222111223566666667655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 1QGR_A 276 ALQGIEFWSNVCDE 289 (876) T ss_pred HHHHHHHHHHHHHH Confidence 88888888777654 No 413 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=79.78 E-value=0.12 Score=50.60 Aligned_cols=146 Identities=14% Similarity=0.095 Sum_probs=76.6 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.++..+...... . . .....++.+...+.+.++.++..++.++..+.... T Consensus 324 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 394 (588) T 1B3U_A 324 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------D-N-TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI 394 (588) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHTTGGGGHHHHCH------H-H-CCCCCHHHHHHHHTCSCHHHHHHHHTTCHHHHHHS T ss_pred hHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHCc------c-c-hHHhHHHHHHHHhcCCCHHHHHHHHhchHHHHHhc Confidence 45566666676 35667777888888777653211 1 1 11345666677777777778888888887776541 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .... ....+++.+...+.+ .+..++..++.++..+....+. ......+++.+..++.+. +..++..++. T Consensus 395 ~~~~-~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 463 (588) T 1B3U_A 395 GIRQ-LSQSLLPAIVELAED------AKWRVRLAIIEYMPLLAGQLGV---EFFDEKLNSLCMAWLVDH-VYAIREAATS 463 (588) T ss_dssp CHHH-HHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHCG---GGCCHHHHHHHHHGGGCS-SHHHHHHHHH T ss_pred CHHH-HHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCh---HHhHHHHHHHHHHHhcCC-hHHHHHHHHH Confidence 1111 111234444444444 2455666666666666542111 111112333444444433 4455555555 Q NP_000290.2 707 LLSDMW 712 (747) Q Consensus 707 aLsnL~ 712 (747) +|..+. T Consensus 464 ~l~~l~ 469 (588) T 1B3U_A 464 NLKKLV 469 (588) T ss_dssp HHHHHH T ss_pred HHHHHH Confidence 555544 No 414 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=79.70 E-value=0.13 Score=50.52 Aligned_cols=152 Identities=11% Similarity=0.094 Sum_probs=94.5 Template_Neff=12.900 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +.+...+. +.++.++..++.+|..++..... ........ ....+++.|+. ++.+.++.++..++.+|..+...... T Consensus 57 ~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~-~~~~~l~~l~~~~~~~~~~~vr~~a~~~l~~l~~~~~~ 133 (536) T 6MZE_Z 57 ELFASYIV-DSNVVAQENAIIALHTLLEYISQ-VPNVSTSK-LRLQWIPPLVEKGLSSSRAATKAKATDCIMLLTQSDTS 133 (536) T ss_dssp HHHHHHHS-CSSHHHHHHHHHHHHHHHHHTSS-SCCTTHHH-HHHHHHHHHCCCCCSCSCHHHHHHHHHHHHHHHHHSSS T ss_pred HHHHHHhc-CchHHHHHHHHHHHHHHHHHhcc-CCCCCcHH-HHHhhHHHHHHhhccCCCHHHHHHHHHHHHHHhccCcc Confidence 55666676 47788899999999888754211 00000011 12345666776 56667788899999999888764111 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK---QYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~---~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+.+ .++.++..++.+|..++........ ......+++.+...+.+. ++.++..++ T Consensus 134 ----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 202 (536) T 6MZE_Z 134 ----IQQTVNLMLPSLSN------KLPRLVSSCVKCLATIIEEFGFINVSDINILLSEILEPLPKLSSHA-DRNVRSETM 202 (536) T ss_dssp ----SHHHHHHHSGGGGC------SCHHHHHHHHHHHHHHHHTTCSCSCTTHHHHHHHHHTTHHHHHTCS-SHHHHHHHH T ss_pred ----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCCcccccccchHHHHHHHHHHhcCC-CHHHHHHHH Confidence 11244555555554 3678888899999888764222110 001234567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 203 ~~l~~l~~~~ 212 (536) T 6MZE_Z 203 NLILQIYKWF 212 (536) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 9988887543 No 415 >5F0N_A cohesin subunit Pds5, KLTH0D07062p; heat repeat cohesin subunit, cell; 3.2A {Lachancea thermotolerans} Probab=79.14 E-value=0.17 Score=59.20 Aligned_cols=150 Identities=8% Similarity=0.095 Sum_probs=100.7 Template_Neff=8.200 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...|. +++..+|..|+.+|+.+....+. .. ... .....++.++..+.+.++.++..++.++..+.... T Consensus 271 ~vlp~L~~~L~-~~d~~vR~~Av~~Lg~l~~~~~~--~~-l~~--~~~~l~~~ll~rl~D~~~~VR~~av~~L~~i~~~~ 344 (1175) T 5F0N_A 271 SVTGLLYQLLC-SDNELFRESATKCVSKMLGTHSL--IN-FAV--AHSDTYKIWLSKMADISPHVRQAWVSEIPSILMSR 344 (1175) T ss_dssp GGHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSCCS--SC-HHH--HTHHHHHHHHGGGSCSCHHHHHHHHTTHHHHHHHC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHccccc--cc-HHH--HcHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHcC Confidence 36777888887 47788999999999988753210 00 011 12346667777788888999999999999887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ....+++.|...+.+ .++.++..++.+|..+..... .........++.|...+.+. ++.+|..|+. T Consensus 345 ~~---l~~~ii~~L~~~L~D------~d~~VR~~av~~L~~l~~~~~--~~~~~~~~ll~~L~~~l~D~-~~~VR~~A~~ 412 (1175) T 5F0N_A 345 SD---LSDDISKGLAKALID------SDHTVRLSAIQTFHEVPVKRL--WECLPNAAVFAGLVHLTRET-RRDLRDECID 412 (1175) T ss_dssp SS---CHHHHHHHHHHHHTC------SSHHHHHHHHGGGTSSCHHHH--HHHCCCHHHHHHHHTTTTCC-SHHHHHHHHH T ss_pred hh---hHHHHHHHHHHHhCC------CCHHHHHHHHHHHHhhhhhhh--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 112355666666766 378899999999988764311 01111134567777777776 7889999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|+.+... T Consensus 413 aL~~l~~~ 420 (1175) T 5F0N_A 413 AVARIYTE 420 (1175) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 98887754 No 416 >4NEE_G AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=78.80 E-value=0.15 Score=48.94 Aligned_cols=115 Identities=12% Similarity=0.097 Sum_probs=71.6 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+..++ . +.++.++..++.+|..+....+. .+....+++.|...+.+.++.++..++.+|..+... T Consensus 149 ~~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 219 (398) T 4NEE_G 149 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 219 (398) T ss_dssp HTTHHHHHHHCS-SSCHHHHHHHHHHHHHHHHHCGG--------GSCCSSHHHHHHGGGGCSCHHHHHHHHHHHHHHHHH T ss_pred HHHhHHHHHhcC-CCCHHHHHHHHHHHHHHHHHChh--------hccccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455666777 6 46778888999999988764221 111245677788888777888999999999988865 Q NP_000290.2 626 PL-LHRVMGNQVFPEVTRLLTSHTG-------NTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 626 ~e-~~~ll~~giI~~Ll~LL~s~s~-------~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .. ........+++.+..++.+... ....++.++..++.+|..+... T Consensus 220 ~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~~~~~ 273 (398) T 4NEE_G 220 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPP 273 (398) T ss_dssp CGGGGTHHHHHHHHHHHHHHHCCTTTTGGGEETTEESHHHHHHHHHHHTTSCSC T ss_pred CHHHHHHHHHHHHHHHHHHHhcCCcCcccccccCCCCHHHHHHHHHHHHhCCCC Confidence 21 1111112345555555543000 0001456777888888887754 No 417 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=78.75 E-value=0.14 Score=55.16 Aligned_cols=158 Identities=8% Similarity=0.034 Sum_probs=93.7 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... ..... ...+++.|...+.+.++.++..++.+|+.++.... T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 3W3U_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTASM-KNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHT-SSCHHHHHHHHHHHHHHHHHHGG-----GCHHH-HHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHHH-HHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3444555555 35667777888888887754221 01111 23567777888888888999999999999887621 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ........+++.|...+.........+..++..++.+|..+....+.... ....+++.++..+....++.++..++. T Consensus 922 ~~~~~~~~~~l~~l~~~l~~~~~~~~~~~~vr~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~~ 999 (1078) T 3W3U_A 922 STYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNYQ 999 (1078) T ss_dssp TTTHHHHHHHHHHHHHHTC-CCTTSHHHHHHHHHHHHHHHHHHHHC--------CCHHHHHHHTTCCCCSCHHHHHHHHH T ss_pred cccHHhHHHHHHHHHHHHhCCCcccccccchHHHHHHHHHHHHHHcccCCC--ChhHHHHHHHHhCCcCCCHHHHHHHHH Confidence 11111134566666666510000003678899999999998875332211 122456666666632226677888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 1000 ~l~~l~~~ 1007 (1078) T 3W3U_A 1000 FLSQLIEN 1007 (1078) T ss_dssp HHHHHHHT T ss_pred HHHHHHHc Confidence 88877754 No 418 >4NEE_B AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=78.75 E-value=0.15 Score=49.03 Aligned_cols=115 Identities=12% Similarity=0.097 Sum_probs=71.5 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+..++ . +.++.++..++.+|..+....+. .+....+++.|...+.+.++.++..++.+|..+... T Consensus 149 ~~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 219 (398) T 4NEE_B 149 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 219 (398) T ss_pred HHHHHHHHHcCC-CCCHHHHHHHHHHHHHHHHHChh--------HhcHhhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455666777 6 46778888999999988764221 111245677788888777888999999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTG-------NTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~-------~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ... .......+++.+..++.+... ....++.++..++.+|..+... T Consensus 220 ~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~~~~~ 273 (398) T 4NEE_B 220 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPP 273 (398) T ss_pred CHHHhHHHHHHHHHHHHHHHcCCCCCCccccccCCCCHHHHHHHHHHHHhhccC Confidence 211 111112345555555543000 0001456777888888887754 No 419 >3DAD_A FH1/FH2 domain-containing protein 1; Formin, FHOD1, GTPase-binding domain, ubiquitin-superfold; 2.3A {Homo sapiens} Probab=78.49 E-value=0.18 Score=50.49 Aligned_cols=154 Identities=13% Similarity=0.081 Sum_probs=94.1 Template_Neff=8.200 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVM-GNQVFPEVTR 642 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll-~~giI~~Ll~ 642 (747) ...++..|..++..... ....|++.+++..|+.++...+......++.+|..|...... ..++ ....+..|.. T Consensus 135 l~~~L~~L~~~l~~d~~-----wv~eFi~~~Gl~~L~~~l~~~~~~~~~~~L~cl~~Lm~~~~G~~~v~~~~~~i~~l~~ 209 (339) T 3DAD_A 135 LRRSLFSLKQIFQEDKD-----LVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYT 209 (339) T ss_dssp HHHHHHHHHHHHHTCTT-----HHHHHHHTTHHHHHHHHHTTSCHHHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHH T ss_pred HHHHHHHHHHHHhCCcc-----HHHHHHHCCHHHHHHHHHHHccHHHHHHHHHHHHHHHhCHHHHHHHHhCHHHHHHHHH Confidence 34566666666521121 345557788999999999876666777888888888776222 2222 2346677777 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS----------SSMLNNIINLCRSS--ASPKAAEAARLLLSD 710 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve----------~giL~~Ll~LL~s~--~d~eVr~aAL~aLsn 710 (747) .+.+ ....++..++.+|..++...+.....+.+ ...+..++..+... .+.+++..++.++.. T Consensus 210 ~l~s------~~~~v~~~al~iL~~l~~~~~~g~~~Vl~al~~~~~~~~~~~f~~lv~~L~~~~~~d~e~~~~~L~LINa 283 (339) T 3DAD_A 210 LCAS------LSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINK 283 (339) T ss_dssp GGGC------SCHHHHHHHHHHHHHHHHHCGGGHHHHHHHHHHHHHHHCCCTTHHHHHHHTTTTSCCHHHHHHHHHHHHH T ss_pred HhcC------CCHHHHHHHHHHHHHHHhcCCCcHHHHHHHHHhHHHhhCCCCHHHHHHHHHhhCCCCHHHHHHHHHHHHH Confidence 7765 35678888888888887654333222222 23466677777642 156677777777777 Q NP_000290.2 711 MWSSKE-------LQGVLRQQGFDRN 729 (747) Q Consensus 711 L~~~~~-------~~~~~~~~~~~~~ 729 (747) |+.... +..-|.+.|+..- T Consensus 284 Ll~~~~d~~~R~~lr~~L~~~Gi~~i 309 (339) T 3DAD_A 284 TLAALPDQDSFYDVTDALEQQGMEAL 309 (339) T ss_dssp HHHHCSSHHHHHHHHHHHHHTTHHHH T ss_pred HHHcCCCHHHHHHHHHHHHHCChHHH Confidence 664433 3344555665443 No 420 >5VJC_A Protein mini spindles; TOG, HEAT Repeat, Tubulin, CELL; 2.0A {Drosophila melanogaster} Probab=78.36 E-value=0.16 Score=46.47 Aligned_cols=73 Identities=11% Similarity=0.004 Sum_probs=44.8 Template_Neff=11.400 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ....+.+...+. +.++.++..++..|..++..... ..... -..++..+...+.+.++.++..++.++..++.. T Consensus 49 ~~~~~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~-~~~l~~~l~~~l~d~~~~v~~~a~~~l~~l~~~ 121 (271) T 5VJC_A 49 ANVNKALIANMF-HDDFRYHLKVIEQLSEDLAGNSK-----ALVCN-LDLILKWLTLRFYDTNPSVLIKGLEYLVQVFQV 121 (271) T ss_dssp TTCCHHHHHHHT-CSSHHHHHHHHHHHHHHTTTCHH-----HHHHT-HHHHHHHHHHHTSSCCHHHHHHHHHHHHHHHHH T ss_pred hcCCHHHHHhcc-CCCHHHHHHHHHHHHHHHhcChH-----HHHHH-HHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHH Confidence 334566777776 46778888888888888764321 01111 123344444555566777888888888877654 No 421 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=78.29 E-value=0.18 Score=59.27 Aligned_cols=156 Identities=10% Similarity=0.095 Sum_probs=112.5 Template_Neff=8.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+++.|.+ +..+..|+..|..++..... ....+...++++.++.+|.+..++++..++.++++++.. + T Consensus 467 qLp~~lq~L~s---~~~r~rAL~~L~~~ld~~~~-----~~~~~~~~gi~p~ll~lL~s~~~~lr~~a~~i~a~i~~~d~ 538 (1287) T 5WBJ_A 467 QLPIVLQVLLS---QCHRFRALVLLGRFLDMGSW-----AVDLALSVGIFPYVLKLLQTTTNELRQILVFIWTKILALDK 538 (1287) T ss_dssp CHHHHHHHTTS---STTHHHHHHHHHHHHTTCHH-----HHHHHHHHTCHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHcC---HHHHHHHHHHHHHHHhcCHH-----HHHHHHHCCcHHHHHHHHcCCCHHHHHHHHHHHHHHHccCH Confidence 46666777752 23677899999998874332 234445679999999999988889999999999999876 3 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-------SSASP 698 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-------s~~d~ 698 (747) .. ..++..+.+..|+.+|.... ..+.++..++.+|+.++...+.....+...+++..+...+. +. ++ T Consensus 539 ~~q~~l~~~~~l~~ll~~L~~~~----~~~~~r~~a~~~Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~-~~ 613 (1287) T 5WBJ_A 539 SCQIDLVKDGGHTYFIRFLDSSG----AFPEQRAMAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQP-EP 613 (1287) T ss_dssp GGHHHHHHTTCHHHHHHHHHCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHCC----------CH T ss_pred HHHHHHHHcCCeeeEEEeecCCC----CCHHHHHHHHHHHHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCC-CH Confidence 33 34455667888888886420 23556778899999998765555555555577788877776 34 67 Q NP_000290.2 699 KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 699 eVr~aAL~aLsnL~~~~~ 716 (747) .++..++.+|..|+...+ T Consensus 614 ~lr~~a~~~L~~L~~~~~ 631 (1287) T 5WBJ_A 614 LFLQWLCLCLGKLWEDFM 631 (1287) T ss_dssp HHHHHHHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHHhccH Confidence 889999999999986654 No 422 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=78.26 E-value=0.18 Score=59.26 Aligned_cols=156 Identities=10% Similarity=0.095 Sum_probs=112.8 Template_Neff=8.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+++.|.+ +..+..|+..|..++..... ....+...++++.|+.+|.+..++++..++.++++++.. + T Consensus 467 ~Lp~~lq~L~s---~~~r~rAL~~L~~~ld~~~~-----a~~~~l~~Gi~p~ll~lL~s~~~~lr~~a~~i~a~i~~~d~ 538 (1287) T 5WBK_A 467 QLPIVLQVLLS---QCHRFRALVLLGRFLDMGSW-----AVDLALSVGIFPYVLKLLQTTTNELRQILVFIWTKILALDK 538 (1287) T ss_dssp SHHHHHHHHTS---GGGHHHHHHHHHHHHTTCHH-----HHHHHHHHTCHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHcC---HHHHHHHHHHHHHHHhcCHH-----HHHHHHHCCcHHHHHHHHcCCCHHHHHHHHHHHHHHHccCH Confidence 46666777752 23677899999998874332 233445679999999999988889999999999999876 3 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-------SSASP 698 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-------s~~d~ 698 (747) .. ..++..+.+..|+.+|.... ..+.++..++.+|+.++...+.....+.+.+++..+...|. +. ++ T Consensus 539 ~~q~~l~~~~~l~~ll~~L~~~~----~~~~~r~~a~~~Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~-~~ 613 (1287) T 5WBK_A 539 SCQIDLVKDGGHTYFIRFLDSSG----AFPEQRAMAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQP-EP 613 (1287) T ss_dssp GGHHHHHHTTTHHHHHHHHHSSC----CCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHCC----------CH T ss_pred HHHHHHHHcCCeeeEEEeecCCC----CCHHHHHHHHHHHHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCC-CH Confidence 33 34455667788888886420 23556778889999998765555555555577888877776 34 68 Q NP_000290.2 699 KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 699 eVr~aAL~aLsnL~~~~~ 716 (747) .++..++.+|..|+.... T Consensus 614 ~lr~~a~~~L~~L~~~~~ 631 (1287) T 5WBK_A 614 LFLQWLCLCLGKLWEDFM 631 (1287) T ss_dssp HHHHHHHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHHcccH Confidence 889999999999986654 No 423 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=78.21 E-value=0.15 Score=53.32 Aligned_cols=154 Identities=10% Similarity=0.027 Sum_probs=92.8 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.+...+.+ .+ +.++..++.+|..+....+. .... .-..+++.+...+.+.++.++..++.++..+.... T Consensus 192 ~~~~l~~~l~~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 264 (852) T 6EN4_C 192 LLPFLKAVCKS-KKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAA 264 (852) T ss_pred HHHHHHHHHcC-CCCHHHHHHHHHHHHHHHhhCch-----hhcc-cHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcC Confidence 34445555552 33 67888888888888754321 1111 12345677777777778889999999998887652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ ....++..++.+|..++...+..........+++.+...+.+. ++.++..++ T Consensus 265 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 337 (852) T 6EN4_C 265 TPYGIESFDSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 337 (852) T ss_pred CHHHHHHHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHhcCCHHHhHHHHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 11 111112345666666654 2456777888888887764222111111124566666666655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..++... T Consensus 338 ~~l~~l~~~~ 347 (852) T 6EN4_C 338 KVVKQCCGTD 347 (852) T ss_pred HHHHHHhhcC Confidence 8888877543 No 424 >5F0O_A cohesin subunit Pds5, KLTH0D07062p, KLTH0G16610p; heat repeat cohesin subunit, cell; 3.5A {Lachancea thermotolerans} Probab=78.20 E-value=0.18 Score=58.49 Aligned_cols=150 Identities=8% Similarity=0.096 Sum_probs=99.5 Template_Neff=8.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...|. +.++.+|..|+.+|+.+...... .. .... ....++.++..+.+.++.++..++.++..+.... T Consensus 280 ~vlp~L~~~L~-~~d~~vR~~Av~~Lg~l~~~~~~--~~-l~~~--~~~l~~~ll~rl~D~~~~VR~~av~~l~~i~~~~ 353 (1133) T 5F0O_A 280 SVTGLLYQLLC-SDNELFRESATKCVSKMLGTHSL--IN-FAVA--HSDTYKIWLSKMADISPHVRQAWVSEIPSILMSR 353 (1133) T ss_dssp TSTTTTTTTTS-CSSHHHHHHHHHHHHHHHHSCCS--ST-TTTT--THHHHHHHHHTTSCSCHHHHHHHTTSHHHHHTTC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHccccc--cc-HHHH--cHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHhcC Confidence 35677778887 47788899999999998653210 00 0111 1345666777778888999999999998887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ....+++.|...+.+ .++.++..++.+|+.+..... .........++.|...+.+. ++.+|..|+. T Consensus 354 ~~---l~~~ii~~L~~~L~D------~d~~VR~~av~~L~~l~~~~~--~~~~~~~~ll~~L~~~l~D~-~~~VR~~A~~ 421 (1133) T 5F0O_A 354 SD---LSDDISKGLAKALID------SDHTVRLSAIQTFHEVPVKRL--WECLPNAAVFAGLVHLTRET-RRDLRDECID 421 (1133) T ss_dssp ST---THHHHHHHHHHTTSC------SSHHHHHHHHTHHHHSCHHHH--HHHCCCHHHHHHHHHGGGBS-SHHHHHHHHH T ss_pred hh---HHHHHHHHHHHHhCC------CCHHHHHHHHHHHhhcchhcH--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 112355666666766 478899999999988764311 01111134567777777766 7888999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|+.+... T Consensus 422 aL~~l~~~ 429 (1133) T 5F0O_A 422 AVARIYTE 429 (1133) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 88887754 No 425 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=77.79 E-value=0.16 Score=49.54 Aligned_cols=109 Identities=15% Similarity=0.189 Sum_probs=67.0 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+... T Consensus 236 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~~~~ 306 (582) T 2NYL_A 236 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 306 (582) T ss_dssp TTHHHHHHHHH-CSSHHHHHHHHHTHHHHHHHHCS-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTS T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHhHHHHHHHHCC-------CC-CHhhhHHHHHHHhcCChHHHHHHHHHHHHHHHHhC Confidence 35566666676 46777888888888887754221 11 1245667777777777788888999998888764 Q NP_000290.2 626 PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... . ......+++.+...+.+ .++.++..++.++..+.. T Consensus 307 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 347 (582) T 2NYL_A 307 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 347 (582) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHHHGGGGHH T ss_pred CCcchHHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 111 1 11112345555555554 245666667777666654 No 426 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=77.60 E-value=0.16 Score=54.65 Aligned_cols=157 Identities=9% Similarity=0.079 Sum_probs=90.3 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.+...+. +.++.++..++.+|..++...+. .... ....+++.|...+.+.++.++..++.+|+.++.. + T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 3W3W_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTAS-MKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHC---CHHHHHHHHHHHHHHHTC--C-----CCHH-HHHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHSS T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3445555555 35667777888888888764221 1111 1245677778888888889999999999999876 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.+...+.........+..++..++.+|..+....+.... ....+++.++..+....+..++..++ T Consensus 922 ~~~~~~~-~~~l~~l~~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~ 998 (1078) T 3W3W_A 922 STYADVC-IPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNY 998 (1078) T ss_dssp TTTHHHH-HHHHHHHHHHTC--CCSSGGGHHHHHHHHHHHHHHHHHTTTSCC----CHHHHHHHTTCCCCSCHHHHHHHH T ss_pred cchHhhH-HHHHHHHHHHHhCCCCcchhchhhHHHHHHHHHHHHHHcccCCC--chhHHHHHHHHhCCccCCHHHHHHHH Confidence 21 1112 34666677766521000003567888899999988765332111 12235566666664222567788888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 999 ~~l~~l~~~ 1007 (1078) T 3W3W_A 999 QFLSQLIEN 1007 (1078) T ss_dssp HHHHC---- T ss_pred HHHHHHHHc Confidence 888777654 No 427 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=77.52 E-value=0.17 Score=44.16 Aligned_cols=115 Identities=13% Similarity=-0.025 Sum_probs=73.8 Template_Neff=12.800 Q NP_000290.2 239 DIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 239 ~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) ........++.+...+.+.++.++..++..+..+....... .....+++.+...+.+.++.++..++.++..+.... T Consensus 27 ~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~---~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~~~ 103 (258) T 4LAC_A 27 CESMSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVE---RTRSELLPFIVELAEDAKWRVRLAIIEYMPLLAGQL 103 (258) T ss_pred CCCccccHHHHHHHHhcCCCHHHHHHHHHHHHHHHHccCHH---HHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhC Confidence 33334456666777777777888888888888877543211 112345566666676777788888888888776543 Q NP_000290.2 319 TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 319 ~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .. ......+++.+...+. +.++.++..++.++..+... T Consensus 104 ~~---~~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~ 141 (258) T 4LAC_A 104 GV---EYFDEKLNSLCMAWLV-DHVYAIREAATSNLKKLVEK 141 (258) T ss_pred CC---hHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHc Confidence 22 1112245556666665 55677888888888887754 No 428 >6FT5_A A3_A3; alphaRep, artificial protein, chimera, bidomain; HET: GOL, SO4; 1.94A {synthetic construct} Probab=77.46 E-value=0.17 Score=47.66 Aligned_cols=60 Identities=17% Similarity=0.244 Sum_probs=30.0 Template_Neff=12.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.+...+. +.++.++..++.+|..+... ..++.+...+.+.++.++..++.++..+. T Consensus 54 ~~~~~l~~~l~-~~~~~vr~~a~~~L~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~ 113 (409) T 6FT5_A 54 RAVEPLIKALK-DEDAWVRRAAADALGQIGDE----------------RAVEPLIKALKDEDGWVRQSAAVALGQIG 113 (409) T ss_pred chHHHHHHHhc-CCCHHHHHHHHHHHHHHcCc----------------hhHHHHHHHhcCCCHHHHHHHHHHHHhhC Confidence 34455555555 34555555666655554321 12233444444555556666666555544 No 429 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=77.42 E-value=0.17 Score=48.11 Aligned_cols=158 Identities=12% Similarity=0.047 Sum_probs=88.7 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS-------GMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~-------~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.+..++.++.+. .++.++..|+.+|.++...... .. ......-....+++.|+..+.+.... +..++.+ T Consensus 35 ~~~~~l~~~l~~~~~~~~~r~~a~~~l~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~-r~~~~~~ 112 (442) T 1F59_B 35 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLHTLGTETYR-PSSASQC 112 (442) T ss_dssp HHHHHHHHHTTCTTSCHHHHHHHHHHHHTTTCCSSH-HHHHHHHHHHHTSCHHHHHHHHHHHHHHTTCCSSS-SCHHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHHhhcCCH-HHHHHHHHHHhhCCHHHHHHHHHHHHHHHCCCCCc-hhHHHHH Confidence 4556667776521 3566777788888887643110 00 00000001234555566666544333 7778888 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) ++.++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+..++.+. T Consensus 113 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 184 (442) T 1F59_B 113 VAGIACAEIPV-NQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 184 (442) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCGGGGGGGHHHHHHHHHHTTSTT- T ss_pred HHHHHHhcCCc-chhchHHHHHHHHhhC------CCCcHHHHHHHHHHHHHHHhhCCHHHhHHHHHHHHHHHHHHHhcC- Confidence 88777541110 0112356666666665 23 67888888998888764221111111124566777777655 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..++.. T Consensus 185 ~~~~~vr~~a~~~l~~l~~~ 204 (442) T 1F59_B 185 EPSNNVKLAATNALLNSLEF 204 (442) T ss_dssp CCCHHHHHHHHHHHHHHSTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78889999988888654 No 430 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=77.33 E-value=0.16 Score=49.36 Aligned_cols=70 Identities=17% Similarity=0.113 Sum_probs=41.5 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.+...+. +.++.++..++.++..+...... . . .....++.+...+.+.++.++..++.++..+... T Consensus 318 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~ 387 (582) T 2NYL_A 318 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------D-N-TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEV 387 (582) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHHHGGGGHHHHHH------H-H-CCCCCHHHHHHHHHCSSHHHHHHHHTTHHHHTTT T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC------c-c-chhhHHHHHHHHhcCCCHHHHHHHHHhHHHHHHh Confidence 34556666666 35666777777777776653211 1 1 1134556666666666667777777777766643 No 431 >5FVM_B SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF; TRANSFERASE, CRYO-EM, TOR, LST8, MTOR; 6.7A {KLUYVEROMYCES MARXIANUS} Probab=77.24 E-value=0.18 Score=61.64 Aligned_cols=71 Identities=11% Similarity=0.111 Sum_probs=39.6 Template_Neff=11.500 Q NP_000290.2 548 AIRTYLNLMGKSKKD-ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~-eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++..+..++.. ... .++..++.++..++..... ....+ -..+++.+...+.+.++.++..++.+|..++.. T Consensus 925 ~~~~l~~~l~~-~~~~~~~~~~~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~L~~l~~~ 996 (2471) T 5FVM_B 925 VIGVLMKILKD-PSLSIHHSTVIQAIMHIFQTMGL-----RCVIF-LKQIIPGFILVMHTCPPSLLELYFQQLSVLISI 996 (2471) T ss_dssp HHHHHHHHHHC----CCHHHHHHHHHHHHHHHC-----------C-HHHHHHHHHHHHC--CHHHHHHHHHHHHHHTTS T ss_pred HHHHHHHHHcC-ccchHHHHHHHHHHHHHHHHccc-----hhHHH-HhHHHHHHHHHHhhCCHHHHHHHHHHHHHHHHH Confidence 34556666652 322 2666777788777653221 01111 134566677777766778888888888888764 No 432 >3LTJ_A AlphaRep-4; protein engineering, HEAT-like repeat, PROTEIN; 1.8A {synthetic} Probab=77.21 E-value=0.18 Score=42.73 Aligned_cols=121 Identities=12% Similarity=0.121 Sum_probs=68.3 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... ..++.+...+.+.++.++..++.++..+... T Consensus 77 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 137 (201) T 3LTJ_A 77 AVEPLIKALK-DEDGWVRQSAAVALGQIGDE----------------RAVEPLIKALKDEDWFVRIAAAFALGEIGDE-- 137 (201) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHTCG-- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHHhCCCHHHHHHHHHHHHHHCCH-- Confidence 3445555565 35566666666666655421 1233444555566667777777776665431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... .....+..++.+. ++.++..++.+ T Consensus 138 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~vr~~a~~~ 192 (201) T 3LTJ_A 138 -------RAVEPLIKALKD------EDGWVRQSAADALGEIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 192 (201) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHCSH-----------HHHHHHHHHHHHC-CHHHHHHHHHH T ss_pred -------HHHHHHHHHHhC------CChHHHHHHHHHHHHhCcH-----------HHHHHHHHHHHcC-CHHHHHHHHHH Confidence 133444455544 2456677777777665431 2334455555555 67778888877 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |.++. T Consensus 193 l~~~~ 197 (201) T 3LTJ_A 193 LETHK 197 (201) T ss_dssp HHHCC T ss_pred HHhhh Confidence 77654 No 433 >5JO8_A CEP104; centriolar protein, TOG domain, CEP104; 1.4A {Gallus gallus} Probab=77.19 E-value=0.18 Score=46.55 Aligned_cols=155 Identities=14% Similarity=0.100 Sum_probs=90.5 Template_Neff=11.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLM---SSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~---s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) .++.+...+. +.++.++..++.++..++...... ... .... .-..+++.|+..+.+.+..++..+..+|..++. T Consensus 87 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~-~~~~~l~~ll~~l~d~~~~vr~~a~~~l~~l~~ 163 (279) T 5JO8_A 87 AIFLVRRAIK-DIVSSVFQASLKLLKMIITQYVPKHKLGKL-ETSH-CVEKTLPGLLSRTGDSSSRLRIVAAKFIQEMAL 163 (279) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHCCCCCHHHHTCCHH-HHHH-HHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHcC-CCHHHHHHHHHHHHHHHHHHhcccccCChH-HHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHc Confidence 3445555666 466778888888888877542000 000 0111 113466777777777778888999999888875 Q NP_000290.2 625 HPLLHRVMGNQVFP-EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 625 ~~e~~~ll~~giI~-~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ..... ...++. .+...+... .++.++..++.+|..++..............+++.+...+.+. ++.++.. T Consensus 164 ~~~~~---~~~~~~~~l~~~l~~~-----~~~~~r~~~l~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~VR~~ 234 (279) T 5JO8_A 164 WSEVK---PLQIVPVHLVQLLKPN-----SPTHLAMSRVELVECLLKEMGTENSGFTISNVMKFATGALEHR-VYEVRDV 234 (279) T ss_dssp STTTG---GGCCHHHHHTSCCCTT-----SCHHHHHHHHHHHHHHHHHHCSSSSSCCHHHHHHHHHHHTTCS-CHHHHHH T ss_pred CCCCC---hhHhHHHHHhhcCCCC-----CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHhcCC-CHHHHHH Confidence 42110 011222 222333331 1566777888888887764322211111224567777777766 8899999 Q NP_000290.2 704 ARLLLSDMWSS 714 (747) Q Consensus 704 AL~aLsnL~~~ 714 (747) +..++..+... T Consensus 235 a~~~l~~l~~~ 245 (279) T 5JO8_A 235 ALRIIFGMYRK 245 (279) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHHH Confidence 99988887643 No 434 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=77.19 E-value=0.18 Score=51.67 Aligned_cols=101 Identities=12% Similarity=0.040 Sum_probs=52.0 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++..+..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 117 ~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~--- 186 (627) T 4P6Z_G 117 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSE-------MCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELM--- 186 (627) T ss_dssp HHHHHHHHHTCSSHHHHHHHHHHHHHHCCHH-------HHHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHCSGGG--- T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHhcCCHH-------HHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHCHHHH--- Confidence 3444444444555556666666665554211 011334455555555566666666666666654322111 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..+++.+...+. +.++.++..++.++..+.. T Consensus 187 --~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~ 217 (627) T 4P6Z_G 187 --EMFLPATKNLLN-EKNHGVLHTSVVLLTEMCE 217 (627) T ss_dssp --GGGHHHHTTCTT-CCCHHHHHHHHHHHHHHHH T ss_pred --HHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 234445555554 4455666666666666654 No 435 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=77.16 E-value=0.17 Score=48.43 Aligned_cols=154 Identities=10% Similarity=0.066 Sum_probs=84.6 Template_Neff=12.800 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM--------S----SGMSQ----LIGLKEKGLPQIARLLQSG----- 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~--------s----~~~~~----~llie~giI~~Ll~LL~s~----- 607 (747) ++.+..++. +.++.++..++.++..++...... . ..... .. .-..+++.+...+... T Consensus 267 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~l~~~l~~~l~~~~~~~~ 344 (460) T 1GCJ_B 267 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKG-ALQYLVPILTQTLTKQDENDD 344 (460) T ss_dssp HHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCSSCCCCHHHH-HHHHHHHHHHHHGGGCCSSSC T ss_pred HHHHHHHhh-CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCcchhhhhhHhH-HHHHHHHHHHHHHhcCCCCCC Confidence 555666666 356777778888888776531000 0 00000 00 0122344444444322 Q NP_000290.2 608 --NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSM 684 (747) Q Consensus 608 --d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~gi 684 (747) +..++..+..++..++..... ..+ ..+++.+...+.+ .++.++..++.+|..+....... ....+ ..+ T Consensus 345 ~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~l~~~l~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~~~-~~~ 415 (460) T 1GCJ_B 345 DDDWNPCKAAGVCLMLLSTCCED-DIV-PHVLPFIKEHIKN------PDWRYRDAAVMAFGSILEGPEPNQLKPLV-IQA 415 (460) T ss_dssp TTSCCHHHHHHHHHHHHHHHHGG-GHH-HHHHHHHHHHTTC------SSHHHHHHHHHHHHHTSSSSCHHHHHHHH-HHH T ss_pred CCCCcHHHHHHHHHHHHHhhCcc-ccH-HHHHHHHHHHhcC------CChHHHHHHHHHHHHHHcCCChhhHHHHH-HHH Confidence 345666677777776654110 111 1234444444444 36778889999999988653321 11111 245 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++++|..++.. T Consensus 416 ~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 444 (460) T 1GCJ_B 416 MPTLIELMKDP-SVVVRDTTAWTVGRICEL 444 (460) T ss_dssp HHHHHHHTTCS-CHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhCCC-CHHHHHHHHHHHHHHHHh Confidence 66667777666 788999999999988754 No 436 >6GWC_C Tubulin alpha chain, Tubulin beta; microtubule, ARTIFICIAL PROTEIN, ALPHAREP, cytoskeleton; HET: GTP, MES, PGE; 2.6A {Ovis aries} Probab=76.89 E-value=0.18 Score=43.85 Aligned_cols=121 Identities=12% Similarity=0.169 Sum_probs=73.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..+... ..++.+..++.+.++.++..++.++..+... T Consensus 108 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 168 (232) T 6GWC_C 108 AVEPLIKALK-DEDTTVRRIAATALGKIGDE----------------RAVEPLIKALKDEDAAVRLTAARALGEIGDE-- 168 (232) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHhccc----------------chHHHHHHHhcCCCHHHHHHHHHHHHHhCCh-- Confidence 3455666665 35667777777777665431 1233455566666777888888777766431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.+|..+... ..+..+..++.+. ++.++..++.+ T Consensus 169 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~v~~~a~~~ 223 (232) T 6GWC_C 169 -------RAVEPLIKALKD------EDAYVRRAAAQALGKIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 223 (232) T ss_pred -------hHHHHHHHHhcC------CCHHHHHHHHHHHHHhCcC-----------chHHHHHHHHhCC-CHHHHHHHHHH Confidence 234445555554 2567777788887776542 2344455555554 66777778777 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |..+. T Consensus 224 l~~~~ 228 (232) T 6GWC_C 224 LETHK 228 (232) T ss_pred HHHHH Confidence 77654 No 437 >3QML_D 78 kDa glucose-regulated protein homolog; Armadillo like repeats, CHAPERONE-PROTEIN TRANSPORT; HET: PO4; 2.31A {Saccharomyces cerevisiae} Probab=76.82 E-value=0.22 Score=49.40 Aligned_cols=104 Identities=8% Similarity=0.064 Sum_probs=73.8 Template_Neff=7.900 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSS--ML 685 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~g--iL 685 (747) ...+..++.-|..++..-++ ..+...+ +..|+.++... .....++..|+++|+..+.+++.....+.+.+ ++ T Consensus 42 ~~~~~~aLd~L~dl~hdid~a~~~~~~g-~~~L~~~l~~~----~~~~~ir~~Aa~iigsa~qNNP~aq~~~~~~~~~~l 116 (315) T 3QML_D 42 IARLEDSFDRIMEFAHDYKHGYKIITHE-FALLANLSLNE----NLPLTLRELSTRVITSCLRNNPPVVEFINESFPNFK 116 (315) T ss_dssp HHHHHHHHHHHHHHHTSHHHHHHHHHHH-HHHHHHHHHCT----TSCHHHHHHHHHHHHHHHTTCTTHHHHHHHHCTTHH T ss_pred HHHHHHHHHHHHHHHccHHHHHHHHHch-HHHHHHHHhCC----CCCHHHHHHHHHHHHHHHhhCHHHHHHHHHHCccHH Confidence 34455566666666655333 3455566 77777776541 02578999999999999999988888888766 67 Q NP_000290.2 686 NNII---NLCRS---SASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 686 ~~Ll---~LL~s---~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) +.|+ ..+.. ..++.++..++.+|+.++.+.+. T Consensus 117 ~~Ll~~~~~L~~~~~~~~~~v~~k~L~aLS~Lir~~~~ 154 (315) T 3QML_D 117 SKIMAALSNLNDSNHRSSNILIKRYLSILNELPVTSED 154 (315) T ss_dssp HHHHHHHHHHHCC---CTHHHHHHHHHHHHHSCCCGGG T ss_pred HHHHHHHHhhccCCCcCCHHHHHHHHHHHHhhcCCCcc Confidence 7777 44443 22678889999999999988765 No 438 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=76.80 E-value=0.18 Score=43.50 Aligned_cols=113 Identities=13% Similarity=0.037 Sum_probs=64.2 Template_Neff=12.600 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++..+..++..............+++.+...+.+.++.++..++.++..++........ T Consensus 6 ~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~d~~~~v~~~a~~~l~~l~~~~~~~~~ 85 (237) T 4G3A_B 6 PSDLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVCTDMGFLIDGLMPWLTGSHFKIAQKSLEAFSELIKRLGSDFN 85 (237) T ss_dssp CSSHHHHHHHSTTCCHHHHHHHHHHHHHHHHCTTSCCCCSCHHHHHHHHGGGGSSSCHHHHHHHHHHHHHHHHHHGGGGG T ss_pred cchHHHHHHhcCcCCHHHHHHHHHHHHHHhhCCCCCcccccHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHhhhhHH Confidence 34455566666677778888888888887764321111111123556666667667778888888888887754332111 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .. ...+++.+...+. +.+..++..++.++..+. T Consensus 86 ~~-~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 118 (237) T 4G3A_B 86 AY-TATVLPHVIDRLG-DSRDTVREKAQLLLRDLM 118 (237) T ss_dssp GT-HHHHHHHHHHHHT-CSCHHHHHHHHHHHHHHH T ss_pred HH-HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHH Confidence 11 1234455555554 334445555555555544 No 439 >6IDX_A Engulfment and cell motility protein; Adhesion GPCRs, CELL ADHESION; 1.699A {Homo sapiens} Probab=76.77 E-value=0.22 Score=52.79 Aligned_cols=157 Identities=13% Similarity=0.168 Sum_probs=98.0 Template_Neff=8.400 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG------NSDVVRSGASLLSNMSRHP-LL-HRVMGN 634 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~~-e~-~~ll~~ 634 (747) ..+..++.-|..++.. .. ....|++.+++..|+.++... +......++.+|..+.... .. ..+. . T Consensus 102 ~~~~~~L~~L~~~~~d-~~-----f~~EFi~~~Gl~~L~~~l~~~~~~~~~~~~~l~~~L~al~~lM~~~~~g~~~l~-~ 174 (524) T 6IDX_A 102 ETRLDAMKELAKLSAD-VT-----FATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVS-I 174 (524) T ss_pred HHHHHHHHHHHHHhcC-hh-----HHHHHHHcChHHHHHHHHHhCCCCCCCChhHHHHHHHHHHHHHhcCcccHhhch-H Confidence 3444566666666653 22 345557788999999988863 4466777888888888764 32 2222 3 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ..+..|..++... ..+..+...++.+|..++...+.....+.....+..|+..|... +..++..++.++..|... T Consensus 175 ~~i~~l~~~l~~~----~~~~~v~~~aL~iL~~l~~~~~~~~~~v~~~~~f~~Lv~~L~~~-d~~~q~~~L~LINaLl~~ 249 (524) T 6IDX_A 175 TFIKQIAGYVSQP----MVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQVS-NQEIQTYAIALINALFLK 249 (524) T ss_pred HHHHHHHHHhCCC----CCChhHHHHHHHHHHHHHhcCHHHHHHHHcCCCHHHHHHHHccC-CHHHHHHHHHHHHHHHhc Confidence 4667777777542 00237888899999888775433333222222377788888765 677778887777777654 Q NP_000290.2 715 K------ELQGVLRQQGFDRNML 731 (747) Q Consensus 715 ~------~~~~~~~~~~~~~~~~ 731 (747) . ++..-|...|+..-.. T Consensus 250 ~~~~~~~~i~~~L~~~gi~~~i~ 272 (524) T 6IDX_A 250 APEDKRQDMANAFAQKHLRSIIL 272 (524) T ss_pred CCcccHHHHHHHHHHcCHHHHHH Confidence 4 3444555666655433 No 440 >6IE1_A Engulfment and cell motility protein; Adhesion GPCR, BAI1-ELMO2 Complex, cell; HET: GOL; 2.48A {Homo sapiens} Probab=76.77 E-value=0.22 Score=52.79 Aligned_cols=157 Identities=13% Similarity=0.168 Sum_probs=98.0 Template_Neff=8.400 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG------NSDVVRSGASLLSNMSRHP-LL-HRVMGN 634 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~~-e~-~~ll~~ 634 (747) ..+..++.-|..++.. .. ....|++.+++..|+.++... +......++.+|..+.... .. ..+. . T Consensus 102 ~~~~~~L~~L~~~~~d-~~-----f~~EFi~~~Gl~~L~~~l~~~~~~~~~~~~~l~~~L~al~~lM~~~~~g~~~l~-~ 174 (524) T 6IE1_A 102 ETRLDAMKELAKLSAD-VT-----FATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVS-I 174 (524) T ss_pred HHHHHHHHHHHHHhcC-hh-----HHHHHHHcChHHHHHHHHHhCCCCCCCChhHHHHHHHHHHHHHhcCcccHhhch-H Confidence 3444566666666653 22 345557788999999988863 4466777888888888764 32 2222 3 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ..+..|..++... ..+..+...++.+|..++...+.....+.....+..|+..|... +..++..++.++..|... T Consensus 175 ~~i~~l~~~l~~~----~~~~~v~~~aL~iL~~l~~~~~~~~~~v~~~~~f~~Lv~~L~~~-d~~~q~~~L~LINaLl~~ 249 (524) T 6IE1_A 175 TFIKQIAGYVSQP----MVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQVS-NQEIQTYAIALINALFLK 249 (524) T ss_pred HHHHHHHHHhCCC----CCChhHHHHHHHHHHHHHhcCHHHHHHHHcCCCHHHHHHHHccC-CHHHHHHHHHHHHHHHhc Confidence 4667777777542 00237888899999888775433333222222377788888765 677778887777777654 Q NP_000290.2 715 K------ELQGVLRQQGFDRNML 731 (747) Q Consensus 715 ~------~~~~~~~~~~~~~~~~ 731 (747) . ++..-|...|+..-.. T Consensus 250 ~~~~~~~~i~~~L~~~gi~~~i~ 272 (524) T 6IE1_A 250 APEDKRQDMANAFAQKHLRSIIL 272 (524) T ss_pred CCcccHHHHHHHHHHcCHHHHHH Confidence 4 3444555666655433 No 441 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=76.57 E-value=0.18 Score=54.22 Aligned_cols=157 Identities=9% Similarity=0.079 Sum_probs=92.1 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.+...+. +.++.++..++.++..++..... .... ....+++.|...+.+.++.++..++.+|+.++.. + T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 5H2V_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTAS-MKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHH-SSSHHHHHHHHHHHHHHHHHHTT-----TTTT-THHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3445555555 35667777888888887754221 1111 1245677778888888889999999999999876 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.+...+.........+..++..++.+|..+....+.... ....+++.++..+....+..++..++ T Consensus 922 ~~~~~~~-~~~l~~l~~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~ 998 (1078) T 5H2V_A 922 STYADVC-IPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNY 998 (1078) T ss_dssp TTTHHHH-TTTHHHHHHHTC--CCSSTTTHHHHHHHHHHHHHHHHHC---------CHHHHHHHTTCCCCSCHHHHHHHH T ss_pred cchHHhH-HHHHHHHHHHHhCCCCccccccchHHHHHHHHHHHHHHcccCCC--ChhHHHHHHHHhCCccCCHHHHHHHH Confidence 21 1111 34666677766521000003567888899999888764322111 11234556666664222567777888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 999 ~~l~~l~~~ 1007 (1078) T 5H2V_A 999 QFLSQLIEN 1007 (1078) T ss_dssp HHHHHHHC- T ss_pred HHHHHHHHc Confidence 888777654 No 442 >1TE4_A conserved protein MTH187; MTH187, Methanobacterium thermoautotrophicum, structural proteomics; NMR {Methanothermobacter thermautotrophicus} SCOP: a.118.1.16 Probab=76.51 E-value=0.19 Score=39.52 Aligned_cols=118 Identities=13% Similarity=0.147 Sum_probs=65.1 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) ..+.+...+. +.++.++..++..|..+.. ..++.+...+.+.++.++..++.++..+... T Consensus 13 ~~~~~~~~l~-~~~~~~r~~a~~~l~~~~~-----------------~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~-- 72 (131) T 1TE4_A 13 GLVPRGSHMA-DENKWVRRDVSTALSRMGD-----------------EAFEPLLESLSNEDWRIRGAAAWIIGNFQDE-- 72 (131) T ss_dssp --------CC-SSCCCSSSSCCSSTTSCSS-----------------TTHHHHHHGGGCSCHHHHHHHHHHHGGGCSH-- T ss_pred CccccHHHhc-CCCHHHHHHHHHHHHHhcH-----------------HHHHHHHHHhcCCCHHHHHHHHHHHHcCCCh-- Confidence 3455666666 4666777777766654421 1234455556666777888888888776532 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.|...+.+ .++.++..++.+|..+... ..++.+...+.+. +..++..++.+ T Consensus 73 -------~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 127 (131) T 1TE4_A 73 -------RAVEPLIKLLED------DSGFVRSGAARSLEQIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 127 (131) T ss_dssp -------HHHHHHHHHHHH------CCTHHHHHHHHHHHHHCSH-----------HHHHHHHHHTTSC-CTHHHHHHHHH T ss_pred -------hhHHHHHHHhcC------CCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHHcCC-CHHHHHHHHHH Confidence 133444455544 2567777788888776531 1344455555544 56677766666 Q NP_000290.2 708 LSD 710 (747) Q Consensus 708 Lsn 710 (747) +.. T Consensus 128 l~~ 130 (131) T 1TE4_A 128 LET 130 (131) T ss_dssp GGG T ss_pred Hhc Confidence 543 No 443 >6S47_Bi 60S ribosomal protein L2-A, 60S; New1, ABCF, Ribosomal Protein, Recycling; HET: ATP; 3.28A {Saccharomyces cerevisiae} Probab=76.45 E-value=0.2 Score=54.82 Aligned_cols=155 Identities=15% Similarity=0.167 Sum_probs=91.4 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) +++.|..++.. .+ +.++..++.+|..++..... .........+++.|+.++.+.++.++..|+.+|..++.. T Consensus 127 ~~~~l~~~l~~-~~~~~vr~~a~~~l~~i~~~~~~-----~~~~~~~~~~~~~l~~~l~d~~~~vr~~a~~~L~~l~~~~ 200 (972) T 6S47_Bi 127 VLPTILDYLSS-GAKWQAKMAALSVVDRIREDSAN-----DLLELTFKDAVPVLTDVATDFKPELAKQGYKTLLDYVSIL 200 (972) T ss_pred hHHHHHHHcCC-CCCHHHHHHHHHHHHHHHhhCCH-----HHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHh Confidence 46667777763 44 67888889998888543221 111112345777788888888888899999988888753 Q NP_000290.2 626 PL-L-H----RV---MG--------------------------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e-~-~----~l---l~--------------------------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. . . .+ +. ..+++.+...+.+. ..+..++..++++|..++. T Consensus 201 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~l~~ 276 (972) T 6S47_Bi 201 DNLDLSPRYKLIVDTLQDPSKVPESVKSLSSVTFVAEVTEPSLSLLVPILNRSLNLS----SSSQEQLRQTVIVVENLTR 276 (972) T ss_pred CcHHHHHHHHHHHHHcCChHHHHHHHHHHHHhhCCCCCCcccHHHHHHHHHHHHhCC----CCCHHHHHHHHHHHHHHHH Confidence 10 0 0 00 00 00223333333220 0245677788888888875 Q NP_000290.2 671 --SQPQLAKQYFSSSMLNNIINLC-RSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 671 --~s~e~~~~Lve~giL~~Ll~LL-~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ........+ ...+++.|+..+ .+. +..++..|+.+|..++.. T Consensus 277 ~~~~~~~~~~~-~~~i~~~L~~~l~~d~-~~~vr~~a~~~l~~l~~~ 321 (972) T 6S47_Bi 277 LVNNRNEIESF-IPLLLPGIQKVVDTAS-LPEVRELAEKALNVLKED 321 (972) T ss_pred hcCChhHcHhh-HHHHHHHHHHHHhcCC-CHHHHHHHHHHHHHHhhh Confidence 211111111 124566777777 555 778899999999998876 No 444 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=76.37 E-value=0.19 Score=44.51 Aligned_cols=96 Identities=7% Similarity=0.086 Sum_probs=47.9 Template_Neff=12.700 Q NP_000290.2 596 GLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 596 iI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .++.+.. ++.+.++.++..++.+|..+...... .....++.+...+.+ .++.++..++.+|..+.. T Consensus 91 ~~~~l~~~~l~~~~~~vr~~a~~~l~~~~~~~~~---~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~---- 157 (280) T 1OYZ_A 91 VFNILNNMALNDKSACVRATAIESTAQRCKKNPI---YSPKIVEQSQITAFD------KSTNVRRATAFAISVIND---- 157 (280) T ss_dssp HHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCGG---GHHHHHHHHHHHTTC------SCHHHHHHHHHHHHTC------ T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCcc---cChhHHHHHHHHhcC------CCHHHHHHHHHHHHhhcc---- Confidence 3444444 44444555555555555554432100 112244455555544 245566666666655442 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) ...++.+..++.+. ++.++..++.++..+. T Consensus 158 -------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~ 187 (280) T 1OYZ_A 158 -------KATIPLLINLLKDP-NGDVRNWAAFAININK 187 (280) T ss_dssp --------CCHHHHHHHHTCS-SHHHHHHHHHHHHHHT T ss_pred -------hhhHHHHHHHHcCC-CHHHHHHHHHHHHhhc Confidence 12345555666655 6677777777777543 No 445 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=76.18 E-value=0.19 Score=42.69 Aligned_cols=111 Identities=10% Similarity=0.045 Sum_probs=61.9 Template_Neff=12.900 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HR---V--MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNL 668 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~---l--l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnL 668 (747) ..++.+...+.+.+..++..++..|..+...... .. . ....+++.+...+.+ .++.++..++.++..+ T Consensus 6 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l 79 (230) T 5NR4_A 6 RSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGS------SNYRVSLMGLEILSAF 79 (230) T ss_dssp CCHHHHHHHTTCSCGGGHHHHHHHHHHHHHC-----CTTSCHHHHHHHHHHHHHHHHC------SSHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHhCCChhHHHHHHHHHHHHhcCCcccCchHHHHHHHHHHHHHHHHHHcC------CCHHHHHHHHHHHHHH Confidence 3455566666667778888888888888765211 10 0 012345555666654 3677888888888888 Q NP_000290.2 669 MASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 669 a~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +...+....... ..+++.++..+.+. +..++..++.++..++. T Consensus 80 ~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~ 122 (230) T 5NR4_A 80 VDRLSTRFKSYV-AMVIVALIDRMGDA-KDKVRDEAQTLILKLMD 122 (230) T ss_dssp HHHHGGGGGGGH-HHHHHHHHHHTTCS-SHHHHHHHHHHHHHHHH T ss_pred HHHhhHHHHHHH-HHHHHHHHHHhccC-CHHHHHHHHHHHHHHHH Confidence 764322111111 23445555555544 45566666666665553 No 446 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=75.90 E-value=0.22 Score=54.55 Aligned_cols=137 Identities=11% Similarity=0.073 Sum_probs=78.0 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|+.++. +.+..++..++.++..+....+. . ..+++.|...+.+.++.++..++.+|..+..... T Consensus 69 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~----------~-~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~~ 136 (874) T 5A1V_E 69 AFFAMTKLFQ-SNDPTLRRMCYLTIKEMSCIAED----------V-IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTM 136 (874) T ss_dssp HHHHHHHGGG-SCCHHHHHHHHHHHHHHHTSCSC----------G-GGHHHHHHHHHHSSSHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHhcccCch----------H-hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHHH Confidence 4555666666 36667777777777776653211 1 2345566666666677777777777776643210 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.++..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 137 -----~~~l~~~l~~~l~d------~~~~Vr~~a~~~l~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (874) T 5A1V_E 137 -----LQAVERYMKQAIVD------KVPSVSSSALVSSLHLLKCSFDVV-----KRWVNEAQEAASSD-NIMVQYHALGL 199 (874) T ss_dssp -----HHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHCHHHH-----HHTHHHHHHHHTCC-SHHHHHHHHHH T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHH-----HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 01234444455544 256677777777777765322111 13445555555544 56667777766 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 200 L~~l~~ 205 (874) T 5A1V_E 200 LYHVRK 205 (874) T ss_dssp HHHHHC T ss_pred HHHHHh Confidence 666654 No 447 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=75.90 E-value=0.22 Score=54.55 Aligned_cols=137 Identities=11% Similarity=0.073 Sum_probs=78.0 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|+.++. +.+..++..++.++..+....+. . ..+++.|...+.+.++.++..++.+|..+..... T Consensus 69 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~----------~-~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~~ 136 (874) T 5NZR_G 69 AFFAMTKLFQ-SNDPTLRRMCYLTIKEMSCIAED----------V-IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTM 136 (874) T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHhcccCch----------H-hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHHH Confidence 4555666666 36667777777777776653211 1 2345566666666677777777777776643210 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.++..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 137 -----~~~l~~~l~~~l~d------~~~~Vr~~a~~~l~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (874) T 5NZR_G 137 -----LQAVERYMKQAIVD------KVPSVSSSALVSSLHLLKCSFDVV-----KRWVNEAQEAASSD-NIMVQYHALGL 199 (874) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHH-----HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 01234444455544 256677777777777765322111 13445555555544 56667777766 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 200 L~~l~~ 205 (874) T 5NZR_G 200 LYHVRK 205 (874) T ss_pred HHHHHh Confidence 666654 No 448 >6HWP_A A3_bGFPD; alphaRep, artificial protein, chimera, bidomain; 2.547A {synthetic construct} Probab=75.54 E-value=0.21 Score=46.83 Aligned_cols=49 Identities=8% Similarity=0.078 Sum_probs=32.0 Template_Neff=12.900 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.++..+.. ...++.+..++.+. ++.++..++.++..+... T Consensus 129 ~~~vr~~~~~~l~~~~~-----------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 177 (409) T 6HWP_A 129 DWFVRIAAAFALGEIGD-----------ERAVEPLIKALKDE-DGWVRQSAADALGEIGGE 177 (409) T ss_dssp SHHHHHHHHHHHHHHTC-----------GGGHHHHHHGGGCS-SHHHHHHHHHHHHHHCCH T ss_pred CHHHHHHHHHHHHHhCC-----------hhhHHHHHHHhcCC-CHHHHHHHHHHHHHhcch Confidence 45666666666666543 12345566666655 678888888888887754 No 449 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=75.50 E-value=0.21 Score=53.79 Aligned_cols=152 Identities=16% Similarity=0.150 Sum_probs=91.0 Template_Neff=13.000 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PL 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e 627 (747) ++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++.. .. T Consensus 358 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 430 (1078) T 3W3U_A 358 FQYLQQMIT-STEWRERFAAMMALSSAAAGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCKVLGQISTAFSP 430 (1078) T ss_dssp HHHHHHHTT-CSSHHHHHHHHHHHHHHTTTTHH-----HHTT-SHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHhc-CCCHHHHHHHHHHHHHHHHccHH-----HHHh-hHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHHccH Confidence 344445554 35677888888888888764321 0111 1135666677777777888999999999998865 11 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .......+++.+...+... .+..++..++.+|..++..... ..... -..++..+...+.+. ++.++..++ T Consensus 431 ~~~~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~~~~~~l~~~l~~~-~~~~~~~~~ 503 (1078) T 3W3U_A 431 FIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVAFSEFASKDILEPY-LDSLLTNLLVLLQSN-KLYVQEQAL 503 (1078) T ss_dssp HHHHHHHHHHHHHHHHHSSTT-----SCHHHHHHHHHHHHHHHTTCCHHHHGGG-HHHHHHHHHHHHTCS-SHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHcCCC-----CCHHHHHHHHHHHHHHHHhCChhhhHHH-HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111123555566655521 2567788888888888764221 11111 123556666666655 667777788 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..++.. T Consensus 504 ~~l~~l~~~ 512 (1078) T 3W3U_A 504 TTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 887776643 No 450 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=75.47 E-value=0.21 Score=43.16 Aligned_cols=107 Identities=13% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+..... T Consensus 59 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~----- 132 (240) T 4QMI_B 59 ELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQH-VKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG----- 132 (240) T ss_dssp THHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHGGGGGGG-CCCCCHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhcHHHHHH-HHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC----- Confidence 344555556666777888888888888876533221111 12355666666666667788888888877765422 Q NP_000290.2 325 TRRQNGI--REAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL--~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++ +.+...+. +.++.++..++.++..++.. T Consensus 133 --~~~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 167 (240) T 4QMI_B 133 --MKEWLEGEDLSEELK-KENPFLRQELLGWLAEKLPT 167 (240) T ss_dssp --SHHHHSSSHHHHHHT-SCCHHHHHHHHHHHHHHGGG T ss_pred --hhHhccHHHHHHHHh-cCCHHHHHHHHHHHHHHHHh Confidence 11244 55566665 55677888888888877653 No 451 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=75.47 E-value=0.21 Score=43.16 Aligned_cols=107 Identities=13% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+..... T Consensus 59 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~----- 132 (240) T 4QMJ_A 59 ELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQH-VKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG----- 132 (240) T ss_dssp THHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHGGGGGGG-CCCCCHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhcHHHHHH-HHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC----- Confidence 344555556666777888888888888876533221111 12355666666666667788888888877765422 Q NP_000290.2 325 TRRQNGI--REAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL--~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++ +.+...+. +.++.++..++.++..++.. T Consensus 133 --~~~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 167 (240) T 4QMJ_A 133 --MKEWLEGEDLSEELK-KENPFLRQELLGWLAEKLPT 167 (240) T ss_dssp --SHHHHSSSHHHHHHH-SSCHHHHHHHHHHHHHHGGG T ss_pred --hhHhccHHHHHHHHh-cCCHHHHHHHHHHHHHHHHh Confidence 11244 55566665 55677888888888877653 No 452 >2IX8_A ELONGATION FACTOR 3A; NUCLEOTIDE-BINDING, PROTEIN BIOSYNTHESIS, PHOSPHORYLATION, ELONGATION; 6.0A {SACCHAROMYCES CEREVISIAE} Probab=75.43 E-value=0.22 Score=54.34 Aligned_cols=153 Identities=11% Similarity=0.112 Sum_probs=91.2 Template_Neff=11.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.|+..+..+.++.++..++.+|..++..... .... .-..+++.|..++.+.+..++..|+.+|..++... T Consensus 128 ~l~~l~~~l~~~~~~~vr~~al~~L~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 201 (976) T 2IX8_A 128 LLPHLTNAIVETNKWQEKIAILAAFSAMVDAAKD-----QVAL-RMPELIPVLSETMWDTKKEVKAAATAAMTKATETVD 201 (976) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHSHH-----HHHH-HHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHSTTCC T ss_pred HHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHH-----hHHh-hchhHHHHHHHhhcCCCHHHHHHHHHHHHHHHHhcC Confidence 4556666662135667778888888888754221 1111 12356777778887778888888888888877531 Q NP_000290.2 627 -LL-H----RVMG-----------------------------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 627 -e~-~----~ll~-----------------------------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .. . .++. ..+++.+...+.+ .++.++..++.+|..++.. T Consensus 202 ~~~~~~~~~~l~~~l~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~l~~l~~~l~~------~~~~vr~~a~~~L~~l~~~ 275 (976) T 2IX8_A 202 NKDIERFIPSLIQCIADPTEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLNE------RETGIKRKSAVIIDNMCKL 275 (976) T ss_dssp SSTTCCCHHHHHHHHHCGGGHHHHHHHCSCTTCCSCCCHHHHHHHHHHHHHHHTS------SSHHHHHHHHHHHHHHHTT T ss_pred cHHHHHHHHHHHHHhcCCCCchHHHHHHHHhhhhccCCchhHHHHHHHHHccCCC------CChhHHHHHHHHHHHHHHH Confidence 00 0 0000 0233344444443 3567888888888888764 Q NP_000290.2 672 QPQLAK-QYFSSSMLNNIINLCRSSAS-PKAAEAARLLLSDMWS 713 (747) Q Consensus 672 s~e~~~-~Lve~giL~~Ll~LL~s~~d-~eVr~aAL~aLsnL~~ 713 (747) .+.... .-....+++.|...+.+. + +.++..++.+|..++. T Consensus 276 ~~~~~~~~~~~~~~~~~l~~~l~d~-~~~~vr~~a~~~l~~l~~ 318 (976) T 2IX8_A 276 VEDPQVIAPFLGKLLPGLKSNFATI-ADPEAREVTLRALKTLRR 318 (976) T ss_dssp CCCHHHHHHHHTTTHHHHHHHHHHC-CCHHHHHHHHHHHHHHHH T ss_pred cCCHHHHHHHHHHHHHHHHHhcCCC-CCHHHHHHHHHHHHHHHH Confidence 211110 001123566677777665 5 7888899999988865 No 453 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=75.38 E-value=0.21 Score=46.90 Aligned_cols=162 Identities=12% Similarity=0.072 Sum_probs=86.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSG--------MSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASL 618 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~--------~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~a 618 (747) +++.++..+. +.++.++..++.+|..++..... ... ..... .-..+++.+...+.+ .++.++..++.+ T Consensus 33 i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~~~~~~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~~ 109 (416) T 5XAH_A 33 VFEEVFKLLE-CPHLNVRKAAHEALGQFCCALHK-ACQSCPSEPNTAALQA-ALARVVPSYMQAVNRERERQVVMAVLEA 109 (416) T ss_dssp HHHHHHGGGS-CSCHHHHHHHHHHHHHHHHHHHH-HHTTSCCHHHHHHHHH-HHHHHHHHHHHHHTTCCCHHHHHHHHHH T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHHHHHHHHH-HhccCCCCCCcHHHHH-HHHHHHHHHHHHHhhccHHHHHHHHHHH Confidence 4566667776 46778888999999888764211 000 00000 112455666666655 567788889999 Q NP_000290.2 619 LSNMSRHPLLH-R---VMGNQVFPEVTRLLTSHTG--------------NTSNSEDILSSACYTVRNLMASQ-PQLAKQY 679 (747) Q Consensus 619 LsnLa~~~e~~-~---ll~~giI~~Ll~LL~s~s~--------------~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~L 679 (747) |..++...... . .....+++.+...+..... ....++.++..++.++..++... +.....+ T Consensus 110 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~ 189 (416) T 5XAH_A 110 LTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPF 189 (416) T ss_dssp HHHHHHHTTHHHHCSTTHHHHHHHHHHHHHTTCSTTC-------------CHHHHHHHHHHHHHHHHHHHHHTSTTTHHH T ss_pred HHHHHHHhcccccCCccHHHHHHHHHHHHHhccchhcCCCcccccccccHHHHHHHHHHHHHHHHHHHHHHhCccchHHH Confidence 98887652111 0 1112345555555543100 00004567778888888887642 1111111 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) + ..+++.+...+....+..++..++.++..++. T Consensus 190 ~-~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~ 222 (416) T 5XAH_A 190 F-AGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQ 222 (416) T ss_dssp H-HHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHH T ss_pred H-HHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHH Confidence 1 13455555555433135666777777776664 No 454 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=75.38 E-value=0.21 Score=46.90 Aligned_cols=162 Identities=12% Similarity=0.072 Sum_probs=86.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSG--------MSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASL 618 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~--------~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~a 618 (747) +++.++..+. +.++.++..++.+|..++..... ... ..... .-..+++.+...+.+ .++.++..++.+ T Consensus 33 i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~~~~~~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~~ 109 (416) T 5XAH_C 33 VFEEVFKLLE-CPHLNVRKAAHEALGQFCCALHK-ACQSCPSEPNTAALQA-ALARVVPSYMQAVNRERERQVVMAVLEA 109 (416) T ss_dssp HHHHHHHGGG-SSCHHHHHHHHHHHHHHHHHHHH-HHHHSCCHHHHHHHHH-HHHHHHHHHHHHHHHCCCHHHHHHHHHH T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHHHHHHHHH-HhccCCCCCCcHHHHH-HHHHHHHHHHHHHhhccHHHHHHHHHHH Confidence 4566667776 46778888999999888764211 000 00000 112455666666655 567788889999 Q NP_000290.2 619 LSNMSRHPLLH-R---VMGNQVFPEVTRLLTSHTG--------------NTSNSEDILSSACYTVRNLMASQ-PQLAKQY 679 (747) Q Consensus 619 LsnLa~~~e~~-~---ll~~giI~~Ll~LL~s~s~--------------~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~L 679 (747) |..++...... . .....+++.+...+..... ....++.++..++.++..++... +.....+ T Consensus 110 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~ 189 (416) T 5XAH_C 110 LTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPF 189 (416) T ss_dssp HHHHHHHHGGGGSCSTTHHHHHHHHHHHHHHTCSTTTC-----------CTTHHHHHHHHHHTHHHHHHHHHTSTTTHHH T ss_pred HHHHHHHhcccccCCccHHHHHHHHHHHHHhccchhcCCCcccccccccHHHHHHHHHHHHHHHHHHHHHHhCccchHHH Confidence 98887652111 0 1112345555555543100 00004567778888888887642 1111111 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) + ..+++.+...+....+..++..++.++..++. T Consensus 190 ~-~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~ 222 (416) T 5XAH_C 190 F-AGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQ 222 (416) T ss_dssp H-HHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHH T ss_pred H-HHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHH Confidence 1 13455555555433135666777777776664 No 455 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=75.07 E-value=0.22 Score=53.62 Aligned_cols=154 Identities=16% Similarity=0.115 Sum_probs=91.6 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 357 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 429 (1078) T 5H2V_A 357 LFQYLQQMIT-STEWRERFAAMMALSSAAEGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFS 429 (1078) T ss_dssp HHHHHHHHTT-CSCHHHHHHHHHHHHHHTTTTHH-----HHTT-SHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhccHH-----HHHh-hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcc Confidence 4555555565 35677888888888888764321 1111 11356666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+. .++.++..++.+|..++...........-..++..+...+.+. ++.++..++ T Consensus 430 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~ 503 (1078) T 5H2V_A 430 PFIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSN-KLYVQEQAL 503 (1078) T ss_dssp THHHHHHHHHHHHHHHHTTSTT-----SCHHHHHHHHHHHHHHHTTCCHHHHGGGHHHHHHHHHHHTTCS-SHHHHHHHH T ss_pred HHHHHHHHHhHHHHHHHHcccC-----CCHHHHHHHHHHHHHHHhcCChhhHHHHHHHHHHHHHHHHhCC-CHHHHHHHH Confidence 11 1111123555555555431 2567788888888888764321110011123455666666554 567777777 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..++.. T Consensus 504 ~~l~~l~~~ 512 (1078) T 5H2V_A 504 TTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 777776653 No 456 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=74.95 E-value=0.24 Score=54.59 Aligned_cols=140 Identities=16% Similarity=0.153 Sum_probs=90.7 Template_Neff=11.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++.++. +.+...+..+..++..+...... ....++..|...+.+.++.++..|+.+|+++..... T Consensus 75 ~~~~l~~ll~-s~~~~~r~~~~~~l~~l~~~~~~----------~~~~ii~~l~~~l~~~~~~vr~~Al~~l~~~~~~~~ 143 (939) T 6OWT_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE----------LIRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (939) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHccCChH----------HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHHH Confidence 3455666776 46667777777777777653221 112456667777777888899999999888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+... .....++.|..++.+. +..++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vR~~a~~~L~~l~~~~~~~~---~~~~~~~~l~~lL~d~-~~~vr~~a~ 208 (939) T 6OWT_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDLV---PMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (939) T ss_pred -----HHHHHHHHHHHHcCCC------CCHHHHHHHHHHHHHHHHHCchhc---ChhhHHHHHHHHhcCC-CHHHHHHHH Confidence 112444555555 33 367889999999999876433221 1234567777777765 677888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~L~~l~~ 216 (939) T 6OWT_A 209 SLITTLAQ 216 (939) T ss_pred HHHHHHHH Confidence 88877765 No 457 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=74.93 E-value=0.22 Score=42.89 Aligned_cols=107 Identities=15% Similarity=0.166 Sum_probs=71.3 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIA-RLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll-~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.++..+. +.+..++..++.+|..+...... ....+++.+. .++.+.++.++..++.++..++... T Consensus 91 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~~l~~~~~~~r~~a~~~l~~l~~~~ 159 (237) T 4G3A_B 91 VLPHVIDRLG-DSRDTVREKAQLLLRDLMEHRVL----------PPQALIDKLATSCFKHKNAKVREEFLQTIVNALHEY 159 (237) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHHHTTSS----------CHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCC----------CHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHh Confidence 5666777776 35667788888888888753111 0123556666 6777777888999999998887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .........+++.+...+.+ .++.++..++.++..+... T Consensus 160 ~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~ 198 (237) T 4G3A_B 160 GTQQLSVRVYIPPVCALLGD------PTVNVREAAIQTLVEIYKH 198 (237) T ss_dssp HHHHCCCGGGHHHHHHHTTC------SSHHHHHHHHHHHHHHHHH T ss_pred CCccccHHHHHHHHHHHHCC------CCHHHHHHHHHHHHHHHHH Confidence 11111113456667777765 3678899999999988764 No 458 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=74.58 E-value=0.23 Score=43.80 Aligned_cols=121 Identities=12% Similarity=0.165 Sum_probs=73.5 Template_Neff=12.400 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... ..++.+...+.+.++.++..++.+|..+... T Consensus 139 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~-- 199 (263) T 4XL5_C 139 AVEPLIKALK-DEDPWVRLTAARALGQIGDE----------------RAVEPLIKALKDEDASVRKAAAVALGQIGDE-- 199 (263) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHCCG-- T ss_pred hHHHHHHHhh-CCCHHHHHHHHHHHHhhCCH----------------HHHHHHHHHhcCCCHHHHHHHHHHHHHhCCh-- Confidence 4455666666 35667777777777655431 2234455566666677788888877766431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+..++.+ .+..++..++.+|..+... ...+.+..++.+. ++.++..++.+ T Consensus 200 -------~~~~~l~~~l~~------~~~~~~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~vr~~a~~~ 254 (263) T 4XL5_C 200 -------RAVEPLIKALKD------EDEYVRQRAASALGKIGGE-----------RVRAAMEKLAEPA-PGFARKVAVNY 254 (263) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHCHH-----------HHHHHHHHHTTTC-CHHHHHHHHHH T ss_pred -------hhHHHHHHHhcC------CCHHHHHHHHHHHHhhCcH-----------HHHHHHHHHhcCC-CcHHHHHHHHH Confidence 234455555554 2566777888888776542 2334444555544 66788888888 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |..+. T Consensus 255 l~~~~ 259 (263) T 4XL5_C 255 LETHK 259 (263) T ss_dssp HHHCC T ss_pred HHHHH Confidence 77654 No 459 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=74.48 E-value=0.23 Score=51.35 Aligned_cols=155 Identities=9% Similarity=0.106 Sum_probs=92.6 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG--LKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll--ie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..+...... ......+ .-..+++.+...+.+.++.++..++.+|..++.. T Consensus 129 ~~~~l~~~l~-~~~~~~~~~al~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 204 (852) T 4FDD_A 129 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 204 (852) T ss_dssp HHHHHHHHHS-CSSHHHHHHHHHHHHHHHHHHTT---HHHHCSSSSCHHHHHHHHTTTTTCSSHHHHHHHHHHHHTTTTT T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHHHh---hcchhhccHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 3455555565 35667777888888877753210 0000000 1134566677777777788899999999888765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .++.++..++.++..+....+....... ..+++.+...+.+. ++.++..+ T Consensus 205 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~a 276 (852) T 4FDD_A 205 RTQALMLHIDSFIENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 276 (852) T ss_dssp TCHHHHTSHHHHHHHHHHHHTC------CCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTCS-SHHHHHHH T ss_pred hHHHHHHhHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcHHHHHHhH-HHHHHHHHHhcCCC-CHHHHHHH Confidence 211 111112355556666654 3567888899999888765332211111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 277 ~~~l~~l~~~ 286 (852) T 4FDD_A 277 CEFWLTLAEQ 286 (852) T ss_dssp HHHHHHHTTS T ss_pred HHHHHHHhcC Confidence 8888887754 No 460 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=74.40 E-value=0.23 Score=44.22 Aligned_cols=124 Identities=11% Similarity=0.101 Sum_probs=69.5 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++.|...+. +.+ +.++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+. T Consensus 9 ~~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~ 71 (294) T 4D4Z_A 9 EQEVDAIGQTLV-DPKQPLQARFRALFTLRGLGG----------------PGAIAWISQAFDDDSALLKHELAYCLGQMQ 71 (294) T ss_dssp HHHHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGCSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc-CCCCCHHHHHHHHHHHHhhcC----------------hhHHHHHHHHhCCCCHHHHHHHHHHHHhcC Confidence 345666777776 344 4577777777766532 123445556666667777888877777664 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .. ..++.+..++.+. ..++.++..++.+|..+... ..++.+...+.+. ++.++.. T Consensus 72 ~~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~v~~~ 126 (294) T 4D4Z_A 72 DA---------RAIPMLVDVLQDT----RQEPMVRHEAGEALGAIGDP-----------EVLEILKQYSSDP-VIEVAET 126 (294) T ss_dssp CG---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCG-----------GGHHHHHHHTTCS-SHHHHHH T ss_pred Cc---------chHHHHHHHhhCC----CCCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHccCC-CchHHHH Confidence 31 2334455555441 01456777777777766431 1233444445444 5556666 Q NP_000290.2 704 ARLLLSDM 711 (747) Q Consensus 704 AL~aLsnL 711 (747) ++.++..+ T Consensus 127 a~~~l~~~ 134 (294) T 4D4Z_A 127 CQLAVRRL 134 (294) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 65555544 No 461 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=74.40 E-value=0.23 Score=44.22 Aligned_cols=124 Identities=11% Similarity=0.101 Sum_probs=69.5 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++.|...+. +.+ +.++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+. T Consensus 9 ~~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~ 71 (294) T 4D50_A 9 EQEVDAIGQTLV-DPKQPLQARFRALFTLRGLGG----------------PGAIAWISQAFDDDSALLKHELAYCLGQMQ 71 (294) T ss_dssp HHHHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc-CCCCCHHHHHHHHHHHHhhcC----------------hhHHHHHHHHhCCCCHHHHHHHHHHHHhcC Confidence 345666777776 344 4577777777766532 123445556666667777888877777664 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .. ..++.+..++.+. ..++.++..++.+|..+... ..++.+...+.+. ++.++.. T Consensus 72 ~~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~v~~~ 126 (294) T 4D50_A 72 DA---------RAIPMLVDVLQDT----RQEPMVRHEAGEALGAIGDP-----------EVLEILKQYSSDP-VIEVAET 126 (294) T ss_dssp CG---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCG-----------GGHHHHHHHTTCS-SHHHHHH T ss_pred Cc---------chHHHHHHHhhCC----CCCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHccCC-CchHHHH Confidence 31 2334455555441 01456777777777766431 1233444445444 5556666 Q NP_000290.2 704 ARLLLSDM 711 (747) Q Consensus 704 AL~aLsnL 711 (747) ++.++..+ T Consensus 127 a~~~l~~~ 134 (294) T 4D50_A 127 CQLAVRRL 134 (294) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 65555544 No 462 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=74.19 E-value=0.24 Score=50.25 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.1 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.+..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~ 217 (621) T 6QH5_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (621) T ss_pred HHHHHHHHhcCC-CCCHHHHHHHHHHHHHHHHhChH--------HccHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 355566666 5 46778888999999988764221 111245677788888888888999999999888764 No 463 >5LPH_B Centrosomal protein of 104 kDa; TOG domain, HEAT repeat, Tubulin; HET: MSE; 2.25A {Homo sapiens} Probab=74.03 E-value=0.26 Score=45.88 Aligned_cols=155 Identities=10% Similarity=0.057 Sum_probs=88.9 Template_Neff=10.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM---SSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~---s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.+...+. +.+..++..++.++..++...... ... .... .-..+++.|+..+.+.++.++..+..+|..++.. T Consensus 94 ~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~-~l~~ll~~ll~~l~d~~~~vr~~a~~~l~~l~~~ 170 (288) T 5LPH_B 94 VFLVRRAIK-DIVTSVFQASLKLLKMIITQYIPKHKLSKL-ETAH-CVERTIPVLLTRTGDSSARLRVTAANFIQEMALF 170 (288) T ss_pred HHHHHHHhC-CCCHHHHHHHHHHHHHHHHHHcccCCCCHH-HHHH-HHHHHHHHHHHHhCCCcHHHHHHHHHHHHHHHcC Confidence 444555565 466778888888888776532000 000 0011 1234667777777777788888899888888765 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..... ...++..+...+... .++.++..++.+|..++...........-..+++.+...+.+. +..+|..+. T Consensus 171 ~~~~~--~~~v~~~l~~~l~~~-----~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~VR~~a~ 242 (288) T 5LPH_B 171 KEVKS--LQIIPSYLVQPLKAN-----SSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHR-VYEVRETAV 242 (288) T ss_pred CCCCc--hhhHHHHHhhccccC-----CCHHHHHHHHHHHHHHHHHHCCCCCCccHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 21100 011223332333321 2466777788888877654322111111224567777777766 789999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 243 ~~l~~l~~~ 251 (288) T 5LPH_B 243 RIILDMYRQ 251 (288) T ss_pred HHHHHHHHH Confidence 998887653 No 464 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=73.90 E-value=0.24 Score=51.58 Aligned_cols=156 Identities=9% Similarity=0.104 Sum_probs=93.2 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLI--GLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~l--lie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..++..... ...... -.-..+++.+...+.+.++.++..++.+|..+... T Consensus 129 ~~~~l~~~l~-~~~~~~~~~al~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 204 (890) T 1QBK_B 129 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 204 (890) T ss_pred HHHHHHHHhc-CCChhHHHHHHHHHHHHHHHHHH---hcchhhccHhHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 4555666665 35667777888888887754221 000000 01134566677777777788899999999988765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .+..++..++.+|..++...+....... ..+++.+...+.+. ++.++..+ T Consensus 205 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~a 276 (890) T 1QBK_B 205 RTQALMLHIDSFTENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 276 (890) T ss_pred hcHHHHHcHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHhCHHHHHHhH-HHHHHHHHHHhcCC-CHHHHHHH Confidence 211 111112345555555554 2567788888888888765332221111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.++..+.... T Consensus 277 ~~~l~~l~~~~ 287 (890) T 1QBK_B 277 CEFWLTLAEQP 287 (890) T ss_pred HHHHHHHhcCh Confidence 88888887653 No 465 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=73.86 E-value=0.24 Score=53.17 Aligned_cols=153 Identities=16% Similarity=0.154 Sum_probs=90.7 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 357 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 429 (1078) T 3W3W_A 357 LFQYLQQMIT-STEWRERFAAMMALSSAAEGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFS 429 (1078) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHTTTTHH-----HHTT-CHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhccHH-----HHHh-hHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 4455555555 35677888888888888764221 1111 1135666677777777788999999999998865 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) .. .......+++.+...+.+. .+..++..++.+|..++..... ..... -..++..+...+.+. +..++..+ T Consensus 430 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~~i~~~l~~~l~~~-~~~~~~~~ 502 (1078) T 3W3W_A 430 PFIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVNFSEFASKDILEPY-LDSLLTNLLVLLQSN-KLYVQEQA 502 (1078) T ss_dssp THHHHHHHHHHHHHHHHHTSTT-----SCHHHHHHHHHHHHHHHHTCCHHHHGGG-HHHHHHHHHHHHTCS-SHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHcccC-----CCHHHHHHHHHHHHHHHhcCChhhHHHH-HHHHHHHHHHHHhcC-CHHHHHHH Confidence 11 1011123555555555431 2567788888888888764321 11111 123455666666544 56677777 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 503 ~~~l~~l~~~ 512 (1078) T 3W3W_A 503 LTTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777776643 No 466 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=73.63 E-value=0.25 Score=47.09 Aligned_cols=158 Identities=12% Similarity=0.052 Sum_probs=89.8 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS------G-MSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~------~-~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.++.++.++.+. .++.++..|+.+|.++...... .. . .....-....+.+.++..+.+. +.++..++.+ T Consensus 35 ~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~~~~~~~~ 112 (462) T 1IBR_B 35 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLQTLGTE-TYRPSSASQC 112 (462) T ss_dssp HHHHHHHHHHHCTTSCHHHHHHHHHHHHHHHCCSSH-HHHHHHHHHHHTSCHHHHHHHHHHHHHHTTCC-CSSSCSHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHHhhcCCH-HHHHHHHHhHhcCCHHHHHHHHHHHHHHHCCC-CCChhHHHHH Confidence 4566677777621 3567888888888887653210 00 0 0000001123445555555442 3457777788 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) ++.++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+...+.+. T Consensus 113 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 184 (462) T 1IBR_B 113 VAGIACAEIPV-NQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 184 (462) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCGGGTGGGHHHHHHHHHHHHSTT- T ss_pred HHHHHhhcCCh-hhcccHHHHHHHHhhC------CCCchHHHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHhCC- Confidence 88777541110 0112356666666665 23 67888899999888764322111111224567777777765 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..++.. T Consensus 185 ~~~~~vr~~a~~~l~~l~~~ 204 (462) T 1IBR_B 185 EPSNNVKLAATNALLNSLEF 204 (462) T ss_dssp CCCHHHHHHHHHHHHHHTTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78889999999888654 No 467 >5VCH_A Kap123; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.35A {Kluyveromyces lactis} Probab=73.42 E-value=0.26 Score=53.37 Aligned_cols=153 Identities=15% Similarity=0.124 Sum_probs=92.7 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..++..... ..... -..+++.+...+.+.++.++..++.++..++... T Consensus 361 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 433 (1116) T 5VCH_A 361 IIEHLPTMLS-SSNPFERRSILLAISVLVTGSPD-----YTLSQ-FDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQ 433 (1116) T ss_dssp HHHHHHHHHH-CSCHHHHHHHHHHHHHHTTTCHH-----HHHHT-HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHSH T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHhcCHH-----HHHHh-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcH Confidence 4555566665 35677788888888888764321 11111 1356677777777777889999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRS-SASPKAAEAA 704 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s-~~d~eVr~aA 704 (747) .........+++.+...+... .+..++..++.+|..++..... ...... ..+++.+...+.+ . ++.++..+ T Consensus 434 ~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~-~~~~~~~~ 506 (1116) T 5VCH_A 434 DEVARYHEQYLPLVIDIIDSA-----KHVVIYKYATLALDGLLEFIAHNDIIKYL-DPLMNKLFQMLETQQ-SPKLRAAI 506 (1116) T ss_dssp HHHHTTHHHHHHHHHHHHHTC-----CSHHHHHHHHHHHHHHHHTSCHHHHHHHH-HHHHHHHHHHHHHCC-CHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhhCCHhhHHHHH-HHHHHHHHHHHhcCC-CHHHHHHH Confidence 111111123555566665541 2567788888888888764222 111111 2356666666665 3 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 507 ~~~l~~l~~~ 516 (1116) T 5VCH_A 507 VSAIGSCAFA 516 (1116) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 8888777653 No 468 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=73.36 E-value=0.26 Score=49.97 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.2 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.|..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 217 (621) T 6QH7_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (621) T ss_dssp HTTHHHHHHTTS-CCCHHHHHHHHHHHHHHHHHCGG--------GCCCCTTHHHHHHGGGCSSHHHHHHHHHHHHHHHTT T ss_pred HHhhHHHHHHcC-CCCHHHHHHHHHHHHHHHHHChh--------hcCccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455566666 5 46778888999999988764221 111245677788888888888999999999888764 No 469 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=73.28 E-value=0.27 Score=49.85 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.0 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.|..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 217 (623) T 2JKT_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (623) T ss_dssp HTTHHHHHHHCT-TSCHHHHHHHHHHHHHHHHHCTT--------TCCCCTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTT T ss_pred HHHhHHHHHHcC-CCCHHHHHHHHHHHHHHHHHChh--------hcCccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 345566666 5 46778888999999888764221 111245677888888888888999999999888764 No 470 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=73.02 E-value=0.27 Score=46.99 Aligned_cols=158 Identities=12% Similarity=0.055 Sum_probs=87.6 Template_Neff=12.800 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS------G-MSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~------~-~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.+..++..+.++ .+..++..|+.+|.++...... .. . .....-....+.+.|+..+.+. ..++..++.+ T Consensus 41 ~~~~~l~~~l~~~~~~~~~r~~a~~~l~~~~~~~~~-~~~~~~~~~~~~l~~~~~~~l~~~l~~~l~~~-~~~r~~~~~~ 118 (460) T 1GCJ_B 41 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLQTLGTE-TYRPSSASQC 118 (460) T ss_dssp HHHHHHHHHHSCTTSCHHHHHHHHHHHHTTTCCSSH-HHHHHHHHHHHHSCHHHHHHHHHHHHHHTTCC-CSSSCHHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHhccCCCH-HHHHHHHHHHHhCCHHHHHHHHHHHHHHHcCC-CCChhHHHHH Confidence 3455666666521 2456777777888876643110 00 0 0000001233455566666543 3477778888 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) +..++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+...+.+. T Consensus 119 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 190 (460) T 1GCJ_B 119 VAGIACAEIPV-SQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 190 (460) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCHHHHGGGHHHHHHHHHHHHCTT- T ss_pred HHHHHHHhCCc-cccchHHHHHHHHhhC------CCCcHHHHHHHHHHHHHHhhhCCHHHhHHHHHHHHHHHHHHHhCC- Confidence 88777541111 0112356666666665 23 67888899999888764221111111224566777777655 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..+... T Consensus 191 ~~~~~vr~~a~~~l~~~~~~ 210 (460) T 1GCJ_B 191 EPSNNVKLAATNALLNSLEF 210 (460) T ss_dssp CSCHHHHHHHHHHHHHHTTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78888888888887653 No 471 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=72.96 E-value=0.27 Score=43.42 Aligned_cols=121 Identities=14% Similarity=0.056 Sum_probs=74.4 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.++..+.... ...++.+...+.+.++.++..++.+|..+... T Consensus 159 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~--------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~- 222 (280) T 1OYZ_A 159 ATIPLLINLLK-DPNGDVRNWAAFAININKYDN--------------SDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDK- 222 (280) T ss_dssp CCHHHHHHHHT-CSSHHHHHHHHHHHHHHTCCC--------------HHHHHHHHHHTTCSCHHHHHHHHHHHHHTTCG- T ss_pred hhHHHHHHHHc-CCCHHHHHHHHHHHHhhcCCC--------------hHHHHHHHHHhcCCCHHHHHHHHHHHhccCCh- Confidence 34566677776 356677777777776553321 13455566667777778888888888776532 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ..++.+...+.+ +.++..++.+|..+... ..++.|...+.+..++.++..++. T Consensus 223 --------~~~~~l~~~l~~--------~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~~~~~vr~~a~~ 275 (280) T 1OYZ_A 223 --------RVLSVLCDELKK--------NTVYDDIIEAAGELGDK-----------TLLPVLDTMLYKFDDNEIITSAID 275 (280) T ss_dssp --------GGHHHHHHHHTS--------SSCCHHHHHHHHHHCCG-----------GGHHHHHHHHTTSSCCHHHHHHHH T ss_pred --------hHHHHHHHHhCC--------ccHHHHHHHHHHHhcch-----------hHHHHHHHHHhcCCCHHHHHHHHH Confidence 234444455543 25677777777776531 245566666665226677888877 Q NP_000290.2 707 LLSD 710 (747) Q Consensus 707 aLsn 710 (747) +|.. T Consensus 276 ~l~~ 279 (280) T 1OYZ_A 276 KLKR 279 (280) T ss_dssp HHTC T ss_pred HHhc Confidence 7764 No 472 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=72.80 E-value=0.28 Score=49.69 Aligned_cols=67 Identities=12% Similarity=0.101 Sum_probs=35.9 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa 623 (747) .++.+..++. +.+..++..++.+|..+...... ... -...++.++..+. +.++.++..++.+|..+. T Consensus 330 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~ 397 (623) T 2JKT_A 330 ACNQLGQFLQ-HRETNLRYLALESMCTLASSEFS------HEA--VKTHIETVINALKTERDVSVRQRAVDLLYAMC 397 (623) T ss_dssp HHHHHHHHHH-SSCSHHHHHHHHHHHHHTTCSSS------CSG--GGGGHHHHHHHHHHCCSHHHHHHHHHHHHTTC T ss_pred HHHHHHHHhh-CCCchHHHHHHHHHHHHHcCcCC------HHH--HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhc Confidence 3455556665 35566677777777766643210 011 1123445555555 555666666666666653 No 473 >5VE8_B Kap123, Histone H3; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.7A {Kluyveromyces lactis} Probab=72.66 E-value=0.27 Score=53.10 Aligned_cols=153 Identities=15% Similarity=0.129 Sum_probs=92.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... ..... -..+++.+...+.+.++.++..++.++..++.... T Consensus 361 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 433 (1116) T 5VE8_B 361 IIEHLPTMLS-SSNPFERRSILLAISVLVTGSPD-----YTLSQ-FDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQ 433 (1116) T ss_dssp HHHTHHHHHH-CSCHHHHHHHHHHHHHHHHHCHH-----HHHHT-HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHhCCHH-----HHHHh-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcH Confidence 4555555665 35677788888888888764321 11111 13566777777777788899999999999886521 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRS-SASPKAAEAA 704 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s-~~d~eVr~aA 704 (747) ........+++.+...+... .+..++..++.+|..++...+. ...... ..+++.+...+.+ . ++.++..+ T Consensus 434 ~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~-~~~~~~~~ 506 (1116) T 5VE8_B 434 DEVARYHEQYLPLVIDIIDSA-----KHVVIYKYATLALDGLLEFIAHNDIIKYL-DPLMNKLFQMLETQQ-SPKLRAAI 506 (1116) T ss_dssp HHHHTTHHHHHHHHHHHHHTC-----CSHHHHHHHHHHHHHHHHTSCHHHHHHHH-HHHHHHHHHHHHHCC-CHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhhcCHhhHHHHH-HHHHHHHHHHHhcCC-CHHHHHHH Confidence 11111123555666665541 2567788888888888764222 111111 2356666666665 3 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 507 ~~~l~~l~~~ 516 (1116) T 5VE8_B 507 VSAIGSCAFA 516 (1116) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 8888777653 No 474 >4ZV6_A AlphaRep-7, Octarellin V.1; synthetic gene, artificial protein, Rossmann-like; 2.22A {synthetic construct} Probab=71.73 E-value=0.3 Score=43.65 Aligned_cols=29 Identities=17% Similarity=0.240 Sum_probs=18.6 Template_Neff=12.500 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++.++..+... T Consensus 140 ~~~l~~~l~~~-~~~~r~~a~~~l~~~~~~ 168 (294) T 4ZV6_A 140 VEPLIKALKDE-DPYVRMAAAYALGKIGDE 168 (294) T ss_pred HHHHHHHhCCC-CHHHHHHHHHHHhhhCCH Confidence 34455555554 667788888888776543 No 475 >6BZX_A alpha-Rep, Octarellin V.1; protein design, artificial protein, DE; 3.107A {synthetic construct} Probab=71.39 E-value=0.31 Score=43.56 Aligned_cols=29 Identities=17% Similarity=0.240 Sum_probs=18.5 Template_Neff=12.500 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++.++..+... T Consensus 140 ~~~l~~~l~~~-~~~~r~~a~~~l~~~~~~ 168 (294) T 6BZX_A 140 VEPLIKALKDE-DPYVRMAAAYALGKIGDE 168 (294) T ss_dssp HHHHHHHTTCS-SHHHHHHHHHHHHHHTCG T ss_pred HHHHHHHhcCC-CHHHHHHHHHHHHHHcch Confidence 34455555554 667788888887776543 No 476 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=70.42 E-value=0.38 Score=55.84 Aligned_cols=154 Identities=9% Similarity=0.047 Sum_probs=91.7 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) +++.|...+.+..++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..++... T Consensus 644 ll~~L~~~l~s~~~~~~r~~al~~L~~l~~~~~~-----~~~~-~l~~ll~~L~~~L~d~~~~VR~~a~~~L~~l~~~~~ 717 (1304) T 5IFE_C 644 LLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717 (1304) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHhhh-----hchh-hHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 4455555555222367788888888888753221 0111 11345666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.|+..+.+ ....++..++.+|..++..............++..|...+.+. +..++..++ T Consensus 718 ~~~~~~~-~~ll~~Ll~~l~~------~~~~v~~~~l~aL~~l~~~~~~~~~~~~~~~ll~~L~~~l~~~-~~~vr~~al 789 (1304) T 5IFE_C 718 PYGIESF-DSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 789 (1304) T ss_pred HHHHHHH-HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCHHHhhhHHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 11 1111 2345666666654 2456677788888877653221111111124566666777655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 790 ~~L~~l~~~~ 799 (1304) T 5IFE_C 790 KVVKQCCGTD 799 (1304) T ss_pred HHHHHHHhcc Confidence 8888877543 No 477 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=70.42 E-value=0.38 Score=55.84 Aligned_cols=154 Identities=9% Similarity=0.047 Sum_probs=91.7 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) +++.|...+.+..++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..++... T Consensus 644 ll~~L~~~l~s~~~~~~r~~al~~L~~l~~~~~~-----~~~~-~l~~ll~~L~~~L~d~~~~VR~~a~~~L~~l~~~~~ 717 (1304) T 6AHD_1 644 LLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717 (1304) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHhhh-----hchh-hHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 4455555555222367788888888888753221 0111 11345666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.|+..+.+ ....++..++.+|..++..............++..|...+.+. +..++..++ T Consensus 718 ~~~~~~~-~~ll~~Ll~~l~~------~~~~v~~~~l~aL~~l~~~~~~~~~~~~~~~ll~~L~~~l~~~-~~~vr~~al 789 (1304) T 6AHD_1 718 PYGIESF-DSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 789 (1304) T ss_pred HHHHHHH-HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCHHHhhhHHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 11 1111 2345666666654 2456677788888877653221111111124566666777655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 790 ~~L~~l~~~~ 799 (1304) T 6AHD_1 790 KVVKQCCGTD 799 (1304) T ss_pred HHHHHHHhcc Confidence 8888877543 No 478 >2QK2_A LP04448p; Mini spindles, Msps, XMAP215, Dis1; 2.1A {Drosophila melanogaster} Probab=70.35 E-value=0.34 Score=41.59 Aligned_cols=113 Identities=7% Similarity=-0.008 Sum_probs=66.2 Template_Neff=12.700 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL-RSPNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL-~s~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ...+++.+...+.+.++.++..++..+..+....+....... ..+++.+...+ .+.++.++..++.++..+....... T Consensus 13 ~~~l~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~ 91 (242) T 2QK2_A 13 LSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLENGEY-GALVSALKKVITKDSNVVLVAMAGKCLALLAKGLAKR 91 (242) T ss_dssp GGGSCTTHHHHHTCSSHHHHHHHHHHHHHHHHHCSSBCCCCC-HHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHHGGG T ss_pred hhhCCHHHHHHHhccchHHHHHHHHHHHHHHhhCcccccchH-HHHHHHHHHHHccCcHHHHHHHHHHHHHHHHHHhhHh Confidence 344555666667777788888999988888764332111111 23566666667 6667788888888888877543322 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .... ...+++.+...+. +.+..++..+..++..+. T Consensus 92 ~~~~-~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 126 (242) T 2QK2_A 92 FSNY-ASACVPSLLEKFK-EKKPNVVTALREAIDAIY 126 (242) T ss_dssp GHHH-HHHHHHHHHHGGG-CCCHHHHHHHHHHHHHHH T ss_pred HHHH-HHhHHHHHHHHHh-cCCHHHHHHHHHHHHHHH Confidence 1111 1234555555554 334455555555555544 No 479 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=70.02 E-value=0.35 Score=47.53 Aligned_cols=71 Identities=15% Similarity=0.238 Sum_probs=44.3 Template_Neff=12.700 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQ---LIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~---~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.++..+. +.++.++..++.+|..++..... . .. .. ....+++.+..++.+.++.++..++.+|..+... T Consensus 138 ~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~---~-~~~~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 211 (554) T 6MZG_E 138 VNLMLPSLS-NKLPRLVSSCVKCLATIIEEFGF---I-NVSDINI-LLSEILEPLPKLSSHADRNVRSETMNLILQIYKW 211 (554) T ss_dssp HHHHSGGGG-CSCHHHHHHHHHHHHHHHHHTCS---C-SCSCHHH-HHHHHHSSHHHHTTCSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC---C-ccccccc-cHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHH Confidence 444555555 35667777888888877653221 0 00 00 1235667777777777788888888888877654 No 480 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=69.91 E-value=0.36 Score=48.86 Aligned_cols=100 Identities=18% Similarity=0.054 Sum_probs=56.7 Template_Neff=12.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+........ ..++..+...+.+.++.++..++.++..+.... . T Consensus 76 ~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~-----~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~-------~ 143 (621) T 6QH7_A 76 HMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELI-----RLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------M 143 (621) T ss_dssp HHHHHHHTTCSSHHHHHHHHHHHHHSCCCCHHHH-----HHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHH-------H T ss_pred HHHHHHHHcCCCccHHHHHHHHHHHHcCCCHHHH-----HHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHH-------H Confidence 3344455555666677777777776654322111 123444555555666777777777777665321 0 Q NP_000290.2 327 RQNGIREAVSLL--RRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 327 ~~~IL~~Ll~lL--~ss~d~eVr~~AL~aLsnLas 359 (747) ...++..+...+ . +.++.++..++.++..+.. T Consensus 144 ~~~l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~ 177 (621) T 6QH7_A 144 AEAFAGEIPKILVAG-DTMDSVKQSAALCLLRLYR 177 (621) T ss_dssp HHHHTTHHHHHHTTS-CCCHHHHHHHHHHHHHHHH T ss_pred HHHHHhhHHHHHHcC-CCCHHHHHHHHHHHHHHHH Confidence 113444455555 4 4566777788888777765 No 481 >1UKL_A Importin beta-1 subunit/Sterol regulatory element; Transcription factor, Nuclear transport factor; HET: MSE; 3.0A {Mus musculus} SCOP: a.118.1.1 Probab=69.90 E-value=0.35 Score=50.26 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=87.3 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.+ +.++..++.+|..+...... . .... ....+++.+...+.+.+ +.++..++.++..+. T Consensus 129 l~~~l~~~l~-~~~~~~~~~~~al~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~~~ 202 (876) T 1UKL_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_dssp SHHHHHHHHH-STTCCHHHHHHHHHHHHHHHHHSCS---T-TTSS-SCHHHHHHHHHTTSTTCSCHHHHHHHHHHHHHHG T ss_pred HHHHHHHHhh-CCCCCHHHHHHHHHHHHHHhccCCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 3455555565 233 56777788888777653221 0 0001 12346666777776655 778888888888876 Q NP_000290.2 624 RH-PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~-~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) .. ... . ......++..+..++.+ .++.++..++.+|..+....+..........+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 1UKL_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_dssp GGCHHHHHSHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHHHHHHTTCGGGGHHHCCCCCHHHHHHHHHCS-CHHH T ss_pred HHhHHhcCCHHHHHHHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHHHHHHhHHhchHHHHHHHHHHhhCC-CHHH Confidence 54 111 0 01112233334444443 3577888899999888765333222122223456666666655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 1UKL_A 276 ALQGIEFWSNVCDE 289 (876) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888777653 No 482 >6EMK_C Serine/threonine-protein kinase TOR2 (E.C.2.7.1.67,2.7.11.1), Target; target of rapamycin, torc2, FRB; 8.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=69.88 E-value=0.38 Score=58.82 Aligned_cols=136 Identities=10% Similarity=0.088 Sum_probs=72.9 Template_Neff=11.300 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) +.++..++.+|..++..... . .... -..+++.|...+.+....++..+..++..+...... ...+ ..+++.+ T Consensus 1016 ~~vr~~a~~~l~~l~~~~~~---~-~~~~--~~~ll~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~l-~~i~~~l 1088 (2474) T 6EMK_C 1016 IKLQITIISVIESISKALEG---E-FKRF--VPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYS-HLIMPIV 1088 (2474) T ss_dssp CCCCCCCSSCCCCCCSSCSC---C-SCCC--CCCCCTTHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC-CCCTTHH T ss_pred hHHHHHHHHHHHHHHHHhhH---h-HHHH--HHHHHHHHHHHHhcCCCCCcchHHHHHHHHHHhhhhHHHHH-HHHHHHH Confidence 34555666666666543221 0 0111 134556666666655445555555565555533111 1111 2244555 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) +..+.. .++.++..++.+|..++..... .. ....++..+...+.+. ++.++..++.+|..++.. T Consensus 1089 ~~~l~~------~~~~vr~~a~~~l~~l~~~~~~--~~-~~~~i~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 1152 (2474) T 6EMK_C 1089 VRMTEY------SAGSLKKISIITLGRLAKNINL--SE-MSSRIVQALVRILNNG-DRELTKATMNTLSLLLLQ 1152 (2474) T ss_dssp HHCCCC------CCCCCTTTTTCCCCCCCCCCCC--CC-CCCCCCCCCCSCCCCC-CCCSSHHHHTTTCCGGGC T ss_pred HHHhcC------CCccHHHHHHHHHHHHHHhCCh--HH-HHHHHHHHHHHHHhcC-CHHHHHHHHHHHHHHHHH Confidence 555554 2567888888888888754221 11 1123566666666654 667788888888777653 No 483 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=69.87 E-value=0.36 Score=42.43 Aligned_cols=49 Identities=10% Similarity=0.082 Sum_probs=29.3 Template_Neff=12.400 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.++..+.. ...++.+..++.+. ++.++..++.++..+... T Consensus 120 ~~~~~~~a~~~l~~~~~-----------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 168 (263) T 4XL5_C 120 DPWVRLTAARALGEIGD-----------ERAVEPLIKALKDE-DPWVRLTAARALGQIGDE 168 (263) T ss_dssp SHHHHHHHHHHHHHHCC-----------GGGHHHHHHHTTCS-SHHHHHHHHHHHHHHCCG T ss_pred CHHHHHHHHHHHHHHCC-----------hhhHHHHHHHhhCC-CHHHHHHHHHHHHhhCCH Confidence 34455555555554432 12345555666655 678888888888877653 No 484 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=69.81 E-value=0.36 Score=42.88 Aligned_cols=127 Identities=10% Similarity=0.093 Sum_probs=78.7 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDA--TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~e--Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++.|...+. +.+.. ++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+.. T Consensus 161 ~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~ 223 (294) T 4D4Z_A 161 RDVGRLREALL-DESRPLFERYRAMFALRNAGG----------------EEAALALAEGLHCGSALFRHEVGYVLGQLQH 223 (294) T ss_dssp CCHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCH----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHHH-hCCCCHHHHHHHHHHHHHcCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHHhcCC Confidence 34566667776 34433 66677777665532 1234455666667777888888888877653 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..++.+...+.+. ..++.++..++.+|+.+... ..++.|..++.+. ++.++..+ T Consensus 224 ~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a 278 (294) T 4D4Z_A 224 E---------AAVPQLAAALARC----TENPMVRHECAEALGAIARP-----------ACLAALQAHADDP-ERVVRESC 278 (294) T ss_dssp G---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCH-----------HHHHHHHHHTTCS-SHHHHHHH T ss_pred h---------hHHHHHHHHHHhC----CCCHHHHHHHHHHHHHhccH-----------HHHHHHHHHhcCC-ChHHHHHH Confidence 2 2344455555520 02567888888888876531 2455666667655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..+.... T Consensus 279 ~~~l~~~~~~~ 289 (294) T 4D4Z_A 279 EVALDMYEHET 289 (294) T ss_dssp HHHHHHHHHC- T ss_pred HHHHHHHHhhc Confidence 88888776443 No 485 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=69.81 E-value=0.36 Score=42.88 Aligned_cols=127 Identities=10% Similarity=0.093 Sum_probs=79.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDA--TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~e--Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++.|...+. +.+.. ++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+.. T Consensus 161 ~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~ 223 (294) T 4D50_A 161 RDVGRLREALL-DESRPLFERYRAMFALRNAGG----------------EEAALALAEGLHCGSALFRHEVGYVLGQLQH 223 (294) T ss_dssp CCHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHHH-hCCCCHHHHHHHHHHHHHcCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHHhcCC Confidence 34566667776 34433 66677777665532 1234455666667777888888888877653 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..++.+...+.+. ..++.++..++.+|+.+... ..++.|..++.+. ++.++..+ T Consensus 224 ~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a 278 (294) T 4D50_A 224 E---------AAVPQLAAALARC----TENPMVRHECAEALGAIARP-----------ACLAALQAHADDP-ERVVRESC 278 (294) T ss_dssp G---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCH-----------HHHHHHHHTTTCS-CHHHHHHH T ss_pred h---------hHHHHHHHHHHhC----CCCHHHHHHHHHHHHHhccH-----------HHHHHHHHHhcCC-ChHHHHHH Confidence 2 2344455555520 02567888888888876531 2455666667655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..+.... T Consensus 279 ~~~l~~~~~~~ 289 (294) T 4D50_A 279 EVALDMYEHET 289 (294) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHhhc Confidence 88888776443 No 486 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=69.69 E-value=0.37 Score=48.79 Aligned_cols=67 Identities=12% Similarity=0.101 Sum_probs=37.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa 623 (747) .++.+..++. +.++.++..++.+|..+...... ... -...++.+...+. +.++.++..++.+|..+. T Consensus 330 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~ 397 (621) T 6QH5_A 330 ACNQLGQFLQ-HRETNLRYLALESMCTLASSEFS------HEA--VKTHIETVINALKTERDVSVRQRAVDLLYAMC 397 (621) T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCCC------hhH--HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhc Confidence 4555666665 35666777777777777653110 111 1224445555555 555666666666666653 No 487 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=69.51 E-value=0.37 Score=42.33 Aligned_cols=88 Identities=10% Similarity=0.162 Sum_probs=47.9 Template_Neff=12.400 Q NP_000290.2 600 IARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQY 679 (747) Q Consensus 600 Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~L 679 (747) +..++.+.++.++..++.++..+.. ...++.+...+.+ .++.++..++.+|..+.. T Consensus 143 l~~~l~~~~~~vr~~a~~~l~~~~~---------~~~~~~l~~~l~~------~~~~~r~~a~~~l~~~~~--------- 198 (263) T 4XL5_C 143 LIKALKDEDPWVRLTAARALGQIGD---------ERAVEPLIKALKD------EDASVRKAAAVALGQIGD--------- 198 (263) T ss_dssp HHHHTTCSSHHHHHHHHHHHHHHCC---------GGGHHHHHHHTTC------SSHHHHHHHHHHHHHHCC--------- T ss_pred HHHHhhCCCHHHHHHHHHHHHhhCC---------HHHHHHHHHHhcC------CCHHHHHHHHHHHHHhCC--------- Confidence 3344444444555555555444432 1223344444444 245566667666666542 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ...++.+..++.+. +..++..++.++..+... T Consensus 199 --~~~~~~l~~~l~~~-~~~~~~~a~~~l~~~~~~ 230 (263) T 4XL5_C 199 --ERAVEPLIKALKDE-DEYVRQRAASALGKIGGE 230 (263) T ss_dssp --GGGHHHHHHHTTCS-SHHHHHHHHHHHHHHCHH T ss_pred --hhhHHHHHHHhcCC-CHHHHHHHHHHHHhhCcH Confidence 12345566666655 677888888888887753 No 488 >6LTJ_L Histone H3.2, Histone H4, Histone; Chromatin remodeler, Complex, GENE REGULATION; 3.7A {Xenopus laevis} Probab=69.20 E-value=0.52 Score=55.12 Aligned_cols=106 Identities=11% Similarity=0.124 Sum_probs=60.8 Template_Neff=5.100 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPLL---HRVMGNQVFPEVTRLLTSHTGNTSNSE----------DILSSACYTVRNLMASQPQL 675 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e~---~~ll~~giI~~Ll~LL~s~s~~~~~d~----------eVr~~Al~aLsnLa~~s~e~ 675 (747) ..+++.++.+|.||+...+. ...+...++..|+.++...... ..++ ..+..|+.+|+.|+.. +.+ T Consensus 1064 ~~LRenaLviLaNIAg~LdLs~~~e~I~~~ild~LLhwlv~~sa~-a~Dp~~~~~~~~~lSp~~lALEaLsKLsv~-d~N 1141 (1295) T 6LTJ_L 1064 EMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAE-AQDPFSTLGPNAVLSPQRLVLETLSKLSIQ-DNN 1141 (1295) T ss_dssp HHHHHHHHHHHHHHGGGCCCSSSCHHHHHHHHHHHHHHHHCCSSS-SSSCCTTSCTTCCCCHHHHHHHHHHHHHTS-HHH T ss_pred HHHHHHHHHHHHHHHcccCCCCCChHhHHHHHHHHHHHHcCcChh-cCChhhccCCCCCCCHHHHHHHHHHHHhCC-Cch Confidence 35667788889998876221 1111112455555544321000 0011 1234589999999874 555 Q NP_000290.2 676 AKQYFSSS-------MLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 676 ~~~Lve~g-------iL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ...++... ++..|+.+|....+..+++.++.+|.+|+...+ T Consensus 1142 ~dlLlat~p~srle~Ll~~LV~lL~~~ed~~lrE~AL~lL~~Ls~~~~ 1189 (1295) T 6LTJ_L 1142 VDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDS 1189 (1295) T ss_dssp HHHHHTSSCHHHHHHHHHHHHHHHHHCSSHHHHHHHHHHHHHHHHHCH T ss_pred HHHHHhCCCHHHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCH Confidence 55555433 566667777644245678899999999987543 No 489 >5WLC_LM rpS18_uS13, rpS4_eS4, rpS5_uS7, rpS6_eS6, rpS7_eS7; Ribosome assembly, RIBOSOME; 3.8A {Saccharomyces cerevisiae BY4741} Probab=69.09 E-value=0.44 Score=57.42 Aligned_cols=153 Identities=6% Similarity=-0.058 Sum_probs=85.4 Template_Neff=9.300 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQL-IGLKEKGLPQIARLLQSGNSDVVRSGASLLSN 621 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~-llie~giI~~Ll~LL~s~d~eVr~~AL~aLsn 621 (747) +++.++..+... .+..++..++.+|..++..... ..... .. -..+++.|...+......++..++.++.. T Consensus 1597 ll~~l~~~L~~~~~~~~~~~~v~~~al~~L~~l~~~~~~---~~~~~~~~-~~~il~~L~~~L~~~~~~v~~~al~~L~~ 1672 (1769) T 5WLC_LM 1597 LLEPVDMLLKRFISKDMENVNLRRLVINSLTSSLKFDRD---EYWKSTSR-FELISVSLVNQLSNIENSIGKYLVKAIGA 1672 (1769) T ss_pred HHHHHHHHHHHhcCCchhcHHHHHHHHHHHHHHHhhCCc---ccccCHhH-HHHHHHHHHHHHHccchHHHHHHHHHHHH Confidence 455555555421 1356677888888887764221 00000 11 13456666666666556677778888888 Q NP_000290.2 622 MSRH-PLLHRVMGNQVFPEVTRLLTSHTGNTSN-SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~~ll~~giI~~Ll~LL~s~s~~~~~-d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. ....... ..+.+.++..+.+ . +..++..++.++..+..........+. ..+++.+.+.+.+. ++. T Consensus 1673 L~~~~~~~~~~~-~~l~~~ll~~l~~------~~~~~vR~~al~~L~~l~~~~g~~~~~~l-~~il~~L~e~Led~-~~~ 1743 (1769) T 5WLC_LM 1673 LASNNSGVDEHN-QILNKLIVEHMKA------SCSSNEKLWAIRAMKLIYSKIGESWLVLL-PQLVPVIAELLEDD-DEE 1743 (1769) T ss_pred HHHhccCChHHH-HHHHHHHHHHhcC------CCCHHHHHHHHHHHHHHHHHHChhHHHhH-hHHHHHHHHHccCC-CHH Confidence 7653 1111111 1133344444433 2 567788888898888765332211111 24567777777765 677 Q NP_000290.2 700 AAEAA-RLLLSDMWS 713 (747) Q Consensus 700 Vr~aA-L~aLsnL~~ 713 (747) ++..+ ..++..+.. T Consensus 1744 Vr~~a~~~~l~~L~~ 1758 (1769) T 5WLC_LM 1744 IEREVRTGLVKVVEN 1758 (1769) T ss_pred HHHHHHHHHHHHHHH Confidence 88888 777776654 No 490 >5YVI_A Transportin-1, RNA-binding protein FUS; Importin family, PROTEIN TRANSPORT, PROTEIN; 2.9A {Homo sapiens} Probab=69.07 E-value=0.37 Score=49.71 Aligned_cols=155 Identities=9% Similarity=0.106 Sum_probs=91.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG--LKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll--ie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..++..... ......+ .-..+++.+...+.+.++.++..++.+|..++.. T Consensus 131 ~~~~l~~~l~-~~~~~~~~~~l~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 206 (868) T 5YVI_A 131 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 206 (868) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHTT---CSCC--CCSTHHHHHHHHGGGGGCSSHHHHHHHHHHHHTTTTT T ss_pred HHHHHHHHhc-CCChHHHHHHHHHHHHHHHHHhh---hcchhhccHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 4555666665 35667777888888887754211 0000000 0134566677777777788888999999888765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .+..++..++.+|..++........... ..+++.+...+.+. ++.++..+ T Consensus 207 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~~ 278 (868) T 5YVI_A 207 RTQALMLHIDSFIENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 278 (868) T ss_dssp TCHHHHTTHHHHHHHHHHTTTC------SSHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTCS-SHHHHHHH T ss_pred chHHHHHhHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcHHHHHHhH-HHHHHHHHHHccCC-CHHHHHHH Confidence 211 111112345555555544 2567788888888888764322111111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 279 ~~~l~~l~~~ 288 (868) T 5YVI_A 279 CEFWLTLAEQ 288 (868) T ss_dssp HHHHHHHHHS T ss_pred HHHHHHHhcC Confidence 8888887764 No 491 >3VWA_A Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; 2.2A {Saccharomyces cerevisiae} Probab=68.93 E-value=0.42 Score=49.31 Aligned_cols=111 Identities=9% Similarity=0.051 Sum_probs=80.6 Template_Neff=10.600 Q NP_000290.2 594 EKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 594 ~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) ..+++.+..++.+.++.++..++..|..++.... .......+++.+...+.+ .+..++..++.+|..++...+ T Consensus 340 ~~~~~~l~~ll~~~~~~vR~~~~~~l~~~~~~~~-~~~~~~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 412 (560) T 3VWA_A 340 VGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLS-KSEISSRIYPHFIQGLTD------SDATLRLQTLKTIPCIVSCLT 412 (560) T ss_dssp TTHHHHHHHHHHCCCHHHHHHHHHHHHHHBTTBC-HHHCCCCCHHHHHHGGGC------SSHHHHHHHHHHHHHHGGGCC T ss_pred cchHHHHHHHcCCCCHHHHHHHHHhHHHHhccCC-HHHHHhchHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCC Confidence 4577888888888888999999999888876411 112234567777777766 367889999999999886432 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .. .....+++.+..++.+. ++.++..++.+|..++... T Consensus 413 ~~---~~~~~ll~~l~~~l~d~-~~~vR~~a~~~l~~i~~~~ 450 (560) T 3VWA_A 413 ER---QLNNELLRFLAKTQVDS-DVEIRTWTVIIISKISTIL 450 (560) T ss_dssp HH---CCCCCCHHHHHHHTTCS-SHHHHHHHHHHHHHHGGGS T ss_pred HH---HHHHHHHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHh Confidence 11 22345677888888766 7899999999999887544 No 492 >3VWA_B Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; HET: MSE; 2.2A {Saccharomyces cerevisiae} Probab=68.86 E-value=0.42 Score=49.21 Aligned_cols=111 Identities=9% Similarity=0.062 Sum_probs=80.6 Template_Neff=10.700 Q NP_000290.2 594 EKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 594 ~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) ..+++.+..++.+.++.++..++..|..++.... .......+++.++..+.+ .++.++..++.+|..++...+ T Consensus 340 ~~~~~~l~~l~~~~~~~vr~~~~~~l~~~~~~~~-~~~~~~~~l~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 412 (560) T 3VWA_B 340 VGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLS-KSEISSRIYPHFIQGLTD------SDATLRLQTLKTIPCIVSCLT 412 (560) T ss_dssp TTHHHHHHHHHHCCCHHHHHHHHHHHHHHBTTBC-HHHCCCCCHHHHHHGGGC------SCHHHHHHHHHHHHHHGGGSC T ss_pred cchHHHHHHHcCCCcHHHHHHHHHhHHHHhhhCC-HHHHhhchHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCC Confidence 4577888888888888899999998888876421 112234567777777776 368899999999999886422 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) . ......+++.|..++.+. ++.++..++.+|..++... T Consensus 413 ~---~~~~~~ll~~l~~~l~d~-~~~vR~~a~~~l~~i~~~~ 450 (560) T 3VWA_B 413 E---RQLNNELLRFLAKTQVDS-DVEIRTWTVIIISKISTIL 450 (560) T ss_dssp H---HCCCCCHHHHHHHHTTCS-SHHHHHHHHHHHHHHHTTS T ss_pred H---HHHHHHHHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHh Confidence 1 122335678888888776 7899999999999887643 No 493 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=68.82 E-value=0.38 Score=40.27 Aligned_cols=109 Identities=12% Similarity=0.007 Sum_probs=69.9 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.++.++..++..+..+....... .....+++.+...+.+.++.++..++.++..+....... T Consensus 7 ~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~~---~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~~~--- 80 (232) T 3C5W_A 7 YPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVE---RLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVE--- 80 (232) T ss_dssp SHHHHHHHHHTCSSHHHHHHHHTTHHHHHHHHCSS---HCCCCCHHHHHHHTTCSSHHHHHHHHTTHHHHHHHHCGG--- T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhChH---HHHHhHHHHHHHHHhCCCHHHHHHHHHHHHHHHHhhCHH--- Confidence 44556666777777888888888888876543211 112345666666677777788888888888776543211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. +.++.++..++.++..+... T Consensus 81 ~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 115 (232) T 3C5W_A 81 FFDEKLNSLCMAWLV-DHVYAIREAATSNLKKLVEK 115 (232) T ss_dssp GTTTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHH Confidence 112235555666665 45677888888888877754 No 494 >4K92_B CLIP-associating protein 1; HEAT-Repeat TOG domain, Regulator of; HET: MSE; 2.005A {Homo sapiens} Probab=68.63 E-value=0.41 Score=43.13 Aligned_cols=109 Identities=12% Similarity=0.075 Sum_probs=66.8 Template_Neff=11.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.++..+.+.+..++..++.++..+..... ...+++.+...+.+.++.++..++.++..++........ T Consensus 129 ~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~~~~~ 201 (273) T 4K92_B 129 EAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH-------IPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL 201 (273) T ss_dssp HHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC-------CTTHHHHHHGGGGCSCHHHHHHHHHHHHHHHHHSCHHHH T ss_pred HHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC-------CchHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHcCchhH Confidence 3445555555555566677777777777765321 123455555666666677888888888877754322100 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......+++.+...+. +.+..++..++.++..+... T Consensus 202 ~~~~~~i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 237 (273) T 4K92_B 202 ERHISVLAETIKKGIH-DADSEARIEARKCYWGFHSH 237 (273) T ss_dssp TTCHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1112345566666665 55778888888888888764 No 495 >6MQ7_B CLIP-associating protein 1; microtubule binding protein, STRUCTURAL PROTEIN; 1.78A {Homo sapiens} Probab=68.63 E-value=0.41 Score=43.13 Aligned_cols=109 Identities=12% Similarity=0.075 Sum_probs=66.8 Template_Neff=11.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.++..+.+.+..++..++.++..+..... ...+++.+...+.+.++.++..++.++..++........ T Consensus 129 ~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~~~~~ 201 (273) T 6MQ7_B 129 EAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH-------IPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL 201 (273) T ss_dssp HHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC-------CGGGHHHHHHGGGCSCHHHHHHHHHHHHHHHHHSCGGGT T ss_pred HHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC-------CchHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHcCchhH Confidence 3445555555555566677777777777765321 123455555666666677888888888877754322100 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......+++.+...+. +.+..++..++.++..+... T Consensus 202 ~~~~~~i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 237 (273) T 6MQ7_B 202 ERHISVLAETIKKGIH-DADSEARIEARKCYWGFHSH 237 (273) T ss_dssp TTCHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1112345566666665 55778888888888888764 No 496 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=68.25 E-value=0.41 Score=41.40 Aligned_cols=109 Identities=7% Similarity=-0.006 Sum_probs=68.9 Template_Neff=12.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+...... ......+++.+...+.+.+..++..++.++..+....... T Consensus 111 ~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~--- 184 (258) T 4LAC_A 111 KLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGK---EWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQD--- 184 (258) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCCh---hHHHHhHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcCCCC--- Confidence 3455556666666778888888888887654322 1112345566666666667778888888888776543221 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. +.++.++..++.++..+... T Consensus 185 ~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 219 (258) T 4LAC_A 185 ITTKHMLPTVLRMAG-DPVANVRFNVAKSLQKIGPI 219 (258) T ss_pred ccHhhHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 112345566666665 55677888888888887653 No 497 >6MQ5_A CLIP-associating protein 1; Microtubule Plus End Binding, STRUCTURAL; HET: MSE; 2.146A {Homo sapiens} Probab=68.04 E-value=0.43 Score=42.33 Aligned_cols=108 Identities=10% Similarity=0.048 Sum_probs=65.9 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAV-QYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll-~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++..+. .++.+.++.++..++.++..+........... ...+++.+...+.+.+..++..+..++..+...... T Consensus 49 ~~~~~l~~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~--- 124 (257) T 6MQ5_A 49 KLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQ-IGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAAN--- 124 (257) T ss_dssp HHHHHCCCCCTTCSSHHHHHHHHHHHHHHHHHHGGGGHHH-HHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHTSC--- T ss_pred HHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHhHHHHHHH-HHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHccC--- Confidence 3444444 44556677788888888888876433221111 134566666666666677788888888777643211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. ..++.++..++.++..+... T Consensus 125 ---~~~~~~~l~~~l~-~~~~~~r~~~l~~l~~l~~~ 157 (257) T 6MQ5_A 125 ---PQYVWDRMLGGFK-HKNFRTREGICLCLIATLNA 157 (257) T ss_dssp ---HHHHHHTTGGGGG-BSSHHHHHHHHHHHHHHHHH T ss_pred ---hHHHHHHHhhhcC-CCCHHHHHHHHHHHHHHHHH Confidence 1234555555564 45677888888888877653 No 498 >2QK1_A Protein STU2; stu2, Stu2p, XMAP215, Dis1, TOG; 1.7A {Saccharomyces cerevisiae} Probab=67.88 E-value=0.42 Score=40.93 Aligned_cols=116 Identities=3% Similarity=-0.016 Sum_probs=68.4 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTN-- 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~-- 321 (747) ..+++.+...+.+.+..++..++.++..+...............+++.+...+.+.++.++..++.++..++...... T Consensus 103 ~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~~~~~~~~ 182 (249) T 2QK1_A 103 SLVFTPLLDRTKEKKPSVIEAIRKALLTICKYYDPLASSGRNEDMLKDILEHMKHKTPQIRMECTQLFNASMKEEKDGYS 182 (249) T ss_dssp HHHHHHHHHGGGCCCHHHHHHHHHHHHHHHHHSCTTCTTCTTHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHCCSCSH T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhChhcccCCHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhccccch Confidence 345556666666666777888888888776543210000111245566666666667778888888888776543310 Q NP_000290.2 322 -KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 322 -~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ........+++.+...+. +.++.++..++.++..+... T Consensus 183 ~~~~~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 221 (249) T 2QK1_A 183 TLQRYLKDEVVPIVIQIVN-DTQPAIRTIGFESFAILIKI 221 (249) T ss_dssp HHHHHCCCCCHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHc-CCCHHHHHHHHHHHHHHHHH Confidence 000111235555666665 55677888888888877653 No 499 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=67.63 E-value=0.43 Score=42.31 Aligned_cols=60 Identities=10% Similarity=0.123 Sum_probs=34.5 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.|...+. +. ++.++..++.+|..+... ..++.+...+.+.++.++..++.+|..+. T Consensus 74 ~~~~~l~~~l~-~~~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 135 (294) T 4D4Z_A 74 RAIPMLVDVLQ-DTRQEPMVRHEAGEALGAIGDP----------------EVLEILKQYSSDPVIEVAETCQLAVRRLE 135 (294) T ss_dssp GGHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHH T ss_pred chHHHHHHHhh-CCCCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHccCCCchHHHHHHHHHHHHH Confidence 34556666666 34 566777777776655421 12334455555556666666666666553 No 500 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=67.63 E-value=0.43 Score=42.31 Aligned_cols=60 Identities=10% Similarity=0.123 Sum_probs=34.5 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.|...+. +. ++.++..++.+|..+... ..++.+...+.+.++.++..++.+|..+. T Consensus 74 ~~~~~l~~~l~-~~~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 135 (294) T 4D50_A 74 RAIPMLVDVLQ-DTRQEPMVRHEAGEALGAIGDP----------------EVLEILKQYSSDPVIEVAETCQLAVRRLE 135 (294) T ss_dssp GGHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHH T ss_pred chHHHHHHHhh-CCCCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHccCCCchHHHHHHHHHHHHH Confidence 34556666666 34 566777777776655421 12334455555556666666666666553