Mercurial > repos > iuc > artic_guppyplex
changeset 0:7a82006f7c05 draft
"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/artic commit dacdfa7ecfbdd1c1a12494cf7d0450185c122c84"
author | iuc |
---|---|
date | Fri, 27 Aug 2021 20:34:52 +0000 |
parents | |
children | 5ceeb5a5d70f |
files | artic_guppyplex.xml macros.xml test-data/SRR11410539_seqtk_sample_500_1.fastq test-data/SRR11410539_seqtk_sample_500_1.fastq.consensus.fasta test-data/all_fasta.loc test-data/gupplyplex_output.fastq test-data/nCoV-2019.V1.bed test-data/nCoV-2019.reference.fasta test-data/nCoV-2019.scheme.V1.bed test-data/nCoV-2019.scheme.V3.bed test-data/primer_scheme_bedfiles.loc test-data/test.fastq tool-data/all_fasta.loc.sample tool-data/primer_scheme_bedfiles.loc.sample tool_data_table_conf.xml.sample tool_data_table_conf.xml.test |
diffstat | 16 files changed, 3814 insertions(+), 0 deletions(-) [+] |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/artic_guppyplex.xml Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,50 @@ +<tool id="artic_guppyplex" name="ARTIC guppyplex" version="@PACKAGE_VERSION@+galaxy0" profile="20.09"> + <description>Filter Nanopore reads by read length and (optionally) quality</description> + <macros> + <import>macros.xml</import> + </macros> + <requirements> + <requirement type="package" version="@PACKAGE_VERSION@">artic</requirement> + </requirements> + <command detect_errors="exit_code"> + <![CDATA[ + mkdir inputs && + #for $i, $elem in enumerate($input) + ln -fs '$elem' inputs/fastq${i}.fastq && + #end for + artic guppyplex --min-length $min_length --max-length $max_length + --directory inputs/ + --prefix artic_guppyplex --output '$output1' + ]]> + </command> + <inputs> + <param name="input" multiple="true" type="data" format="fastq" label="Nanopore reads (FASTQ format" /> + <param name="max_length" type="integer" label="Remove reads longer than" value="700" help="remove reads greater than this number of base pairs" /> + <param name="min_length" type="integer" label="Remove reads shorter than" value="400" help="remove reads less than this number of base pairs" /> + <param name="skip_quality_check" argument="--skip-quality-check" type="boolean" truevalue="--skip-quality-check" falsevalue="" checked="False" label="Do not filter on quality score (speeds up processing)" /> + </inputs> + <outputs> + <data name="output1" format="fastq" from_work_dir="run_name_.fastq" /> + </outputs> + <tests> + <test> + <param name="input" value="test.fastq" /> + <output name="output1" file="gupplyplex_output.fastq"/> + </test> + </tests> + <help><![CDATA[ + The ARTIC_ guppyplex tool filters reads by length and (optionally) quality. + This filter is typically used as a pre-processing step in the processing + of amplicon sequencing Nanopore reads, where a size-based filter can + be used to remove possibly-chimeric reads. + + The default paramters of the tool (minimum length of 400 and maximum of 700) + are based on the ARTIC amplicon scheme. If used with a different amplicon + scheme they should be adjusted to use the minimum length of an amplicon as + the minimum length and the maximum length of an amplicon plus 200 as the + maximum length. + + .. _ARTIC: https://artic.readthedocs.io/en/latest/ + ]]></help> + <expand macro="citations" /> +</tool> \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/macros.xml Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,18 @@ +<macros> + <token name="@PACKAGE_VERSION@">1.2.1</token> + <xml name="citations"> + <citations> + <citation type="bibtex"> + @misc{githubartic-ncov2019, + author = {Nick Loman and the ZiBRA Project and the ARTIC project}, + year = {2017}, + title = {ARTIC toolkit}, + publisher = {GitHub}, + journal = {GitHub repository}, + howpublished{\url{https://github.com/artic-network/fieldbioinformatics}}, + } + </citation> + <yield /> + </citations> + </xml> +</macros>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/SRR11410539_seqtk_sample_500_1.fastq Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,2000 @@ +@SRR11410539.882919 882919/1 +CTTGGGCATTAGTCGTTCAGTTACATGTACTAAGGTTAAACAGACGACTACAAACGGAATCCCGACAGCACCTACCAATAACTTTCAAATCGTAGTCTGTTCTCTAAATATGAACTTTAAAATCTGTGTGGCTGTCATCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCATCTTCTGCAGGCTGCTTACGGTTCGTCCGTGTTGCAGCCGATCCTCTTTATCTAGGTTTGTCGGGTGTGACCGAAGGTAAGATGGAGAGCCTTGTCCCCTGGTTTCAACGAGAAAACACGTCCAGTTTGCCTGTTTTACAGGTTCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGAGTCTTATCAGAGCACGTCAACATCTTAAAGATGAGGGTGCTATTGGTTTTCCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTTT ++ +$0%#%$##'*(&)&&*)0/09711$$$&&/3%%)*3;:<:99:;;992&6;DF;<$&,2%%6/8:64=D@B?>:37//.11%%%%'#%--($&%&)077AB:6A4/0.)'(+.223301344/3%'(*0169<,(3%''$%%,+5//,((,40=,8%$8@>?=/&&15676.0++)1335:<:?<;>9;>=A??6**5<830-%&)4//265/1'59:H@=>3//8:53/-13AE8<A:<:9:?977#%''&&++.0&&)%$%&'*12/05;ABC<4F)/AAAA?=99450*>;;=?B??B@/)+42.28122+*2/4//)<126,,.2,<9:,83$$-&9@<=6;<DA<<H4@@=CCAA3038)%%'74.30+(/++*,.3010-7@A7<@C895.'0:>@>54800+8=<70/6)*>9;EJBDE@0:24&'(4<::3)).,.,/1,&,&*,0C=@<=9?;7>>;77*+,)-),%&*//;>B?<72&'+* +@SRR11410539.1188960 1188960/1 +TATTACTACCATTCGTTCCCATGCCTTACTAAGGTCACTCGACCAACTCTGGCATGAATCGACAGCACGCGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAGCTTTTGGCAATCATCTGGATGCACCCACACCACTAGGCATTGATTTAGATAGTGGAGTATGGCTACATACTACTTGTTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCAGATGAGGATGAAGAAGGTGATTGTGAAGAGAAGTTTGAGCCATCAAACTCAATATGAGTATGTAGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCGCACTTCTGCATCTTCAACTGAAGAGCAAGAAGAAGATTGGTTAGATCGAAGGTGCTGTCAATTCCGTTTGTAGTAATCTGTTTAACCTTAGCAATACGTAACTT ++ +#$#$$#$$%%%%'%&$$%)(%%###$%($%))('('%"$%#$#%#%"'-$"##$&%&*&086)%421$$*%&).6./8<ACFELGBBCACC>;:B@>D2:BF@21&+/?@C=80.B<<B?:<:9=<614)9844<?BABF93;11234'/003+&'*()%#&.9+)+)0%%(***/1632.&&&13>=><1./15-101'*914,6=;?<=>:-.52261+((*'-065280,-.;-58@32?EDA8923<0:552:8;602<;03+.<:=:?3/0(1>?<(780@/4)<?=2'&8,,((2.)''+-,&$5,+$&''-22111<;4-:9:09-7((.-)&*,10%%$%*.&%167B@@EIFMD=79./40459::BA@=*/*0058&&,$$%029;:76'$#//=9://1(++69;36=:'0-,3)4//558=>--.%&&&-).<0.5&))&($'%5499<+&+$$%%.64<9;?970((+</89994@:;00%%( +@SRR11410539.1794060 1794060/1 +CATTTATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTTGCATTACCAGCTTGTGAACGATGCTGTGGCAGCTAAACTACCAAGTACCATACCTCTATTTAGGTTGTTTTAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCTACAAGGTGGTTTGATTCTGTATAGATAGTACCAGTTCCATCACTCTTAGGGAATCTGGCCATTTCAAATCATTAAATCGGATAACAGGCACAAGTACAAACCTACCTCCCTTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTAATAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +0&&)*&'-'79;9;N+.&<>>6)$.&,0??C:;/ID>;=3?34,7:567>:67*2#&&.9;=D-=*<@DA65-//2=B:;3..-9?IKLCBDIDC@A+%,A?7878408;7:.--0./,*/145<C;D;9:92,,))+7;944$$*'+($$%&%)$#&383436.4)CD>?<;;:()&73767:9224BB?<:846?AC9?;GB7;89;=CEBC:A@ABGCA@C+$$589??>CC@@7@A4756731-/091+6+,4/15>?9<;<A<:;0<436FD:87=/5<:;;758<967>><8;=A;;81+<++??A6-;>;94*>-2877===6<00*&5%&/;>4*<9=;D430&)&$$%)+,.+*)-)@@F5336:?=?BGC?AE:AB=AB3.:=89622--,3B@@BC>>315-1B<A/006/?CCE68>4528<AAAB/+;;53,---32;=>47293200.,437;:8<BA>@:<8724$$(109;99::@?@D<<5;90;&5761>@9/-.)* +@SRR11410539.635976 635976/1 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+TGATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACAGTATTCTTTGCTATAGTAGTCGGCATAGATGCTTTAATTCTAAATTTGTACTTCTAGTAAAAGTACACAATTGTAGCAATAAAGTAAAGAAATGGAAGCATATAATTAGTACAAACACGGTTTAAACACCGTGTAACTATGTTAGTAGTTGTACTAACAACTTTGTTAAGAAAAGGCTTAGCATAATTAGCTATAGTATCCCAAGGGACACTATTAACAGCAGCTAAACCATGAGTATGAGGGTTTTCAAACCCTAATACTCTAGATAGTTTGATAGGTTTCTTAATAGTAAGACTAGAATTGTCTACATAAGCAGCCATTAGATCTGTGTGGCCAATATCTTCTGTAATTTTTAAACTATGCTGGTTTAAGTATAATGTCTCCTACAACTTCGGTAGTAGGTGCTGTCGATTCCGTTTGTAGTCATCTGTTTAACCTTAGCAATACGTAAC ++ 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTTCTAAACGGAATCCGACAGCACCTTGTTTATCACCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGAGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTACAGCTAGGTTTTCTACAGGTGTTAACCTGGTTGCTGTACCTACAGGTTATGTTGATACACCCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAGATTGTACAAATGTTAAGTGACACCTTAAAAATCTCTCCTGACAGAGTCGTATTTGTCTTATGAAAGCATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTTTA ++ +(%$%*.-<A>@AK170:ADF?>;933,8:==0DPHINE=//51,)%.($%12+(())+''85;@A@CC?@CHAABA/*5-+49;%%*9>:3=<6;ACDB0<;?@B@;G@G@@4815@)0<>>@1151-0-,%&(@?<=<B;2;B?<A6:-0/3@ADD>)-62.:25169--.-4322<B===@@@OGDA;9788@F=?11;<5%+<@DB><:847448835;>F;<>@C><=>AD>>7BD;?AA9<AC@IHNKE27@57GFF>?FCCCFI>A:@=<>A?F<0@&74;/2/5HELDA?BC4?2A?=?<=AHCAEEJB<=$9DF:SK:;ADEI@@BC=@<IE=BB<ABD-?@F<>C??AC:<?>,-.CA<=9%*%'258?@8:?1=%(DEA@J@>F9:8;6::H:=?::3./.0&$,,B?=8CEEBBDA??A=B@CB4:9=-<HGGIOLBEA@@GB@??@<:;:<=FDCFB98ECFDA;?AD=<>?AD?<?F@>@C?CBFJH;=>MIH88<7<=:7>>=EFD@@::73,<;@ACK@;80.##&&$ +@SRR11410539.95343 95343/1 +TATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAACGGAATCGACAGCACCTTGCTTGACGTACAAAAACTGCCATATTGCAACAAAGATTGCTGCATTCAGTTGAATCACCACAAATGTACATTGCAAATCTACTGATGTCTTGGTCATAGACACTGGTAGAATTTCTGTGGTAACACTAATAGTAAAATTTGTGGGTATGGCAATAGAGTTATTAGAGTAAGCAACTGAATTTTCTGCACCAAGTGACATAGTGTAGGCAATGATGGATTGACTAGCTACACTACGTGCCCGCCGAGGAGAAGGAGTAGTCTGAGTCTGATAACTAGCGCATATACCTGCACCAATGGGTATGTCACACTCATAGCGGTTGTTGACATGTTCAGCCTATTAAACAACCTGCGTGTTTGAAAAGCAGTAGAACCTGTAGAATAAACACGCCAAGTAGGAGTAAGTTGAGGTGCTGTCGATTCCGTTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +))*+8;<78;89</0**+.'%%&%%'&&))*/01230#'**73AB:9=9<25:)+,8.42A977:;;=<;-++,)),%.+0;=:<9:E@EC=?@DB4=BD@KID).&6@AKJA?D960;B?A96=?0?A=CCDF<>?<?44)&,,2;;?@779@<2)(3/18>;@E>;9<97/169?I::=4485;<;13>=>=FE7B9-,<;?A808=A)<@@CBA<31-:<;></?.3DD:A18B@9;)B889?@<7-CH2468//8<&'-6'&=<870)-2--00-.555?11&)-)))--114<A8;3-30A1>>BCH??4E09,'&&$$&;:?9<3:/<=EB@?@67<@:8:@@AA?::?<DDEEC>@==6;979882<?G@@A>-+0(,',>D@5:?;9=:?D<73885=<=>?A55&'-%/0+;FE<<52,,**%'&$)264GA>AB6A46JDIMF:=>1:9455;F:7,8>>ABEBA627764.,%)1258,.&$'C<1/98;933=;>A?>?B)/).F@CAB;<=@A60$( +@SRR11410539.1119342 1119342/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAATTTGACTACAAACGGAATCGACAGCACCTCTTTTCTCCAAGCAGGGTTACGTGTAAAAAGAATTCTTACCACGCCTATTTGTGGCCTGTTAATTGCAGATGAAACATCATGCATTAACACCTATAAAAACAATTTTTAAAGCATTGAGCTGATTTGTCTTTATTGCTTTTCACTAAGCTTATTATCATAAACCAAAGCACTCACAGTGTCAACAATTTCAACAGGACAACGCCGACAAGTTCCGAGGAACATGTCGGACCCTACTCATAAGTCTACACACTTGAATTGAAATATTCTGGTTCTAGTGTGCCCTTAGTTAACAATGTGCGTGGTGCAGGTAGTGAGGTCGCCAATGTACACATAGTGCTTAGCACGTAATCTGGCATTGACAACACTCAAAATCGTTCAGATTCCTTCGTGTCTGTTTAACCA ++ +#$*++4.<=?;8K87'&=@;9AIMKJBBC;;(FIIEF?/%$$#&'9.9>B@;<64-0.799=A:1@BAAB?:?DOFBB*9/0)(&5=A:=:2-;50.0-(&$0.3*)567;6(49>??2876+800.0)+*0;?7:>B?@<688@F;=;<872*'$$'%%$,($&(9;51*2%1+132-,.**,&&+2-.((.-06GA;<D=2))1'$$$$$#$%)..;788<;3<9>@C>A850;;6/5DCD@>2.;<2+@./<-0-.?C12-+15?855<@?<=F>78:B@%,20)*0+2<>5,+*.85421--)**669=<:4,%')&&(*4/38<>BCAAA>=@8262%,'-0=2;(+1114088=..3)+$&23:<FCDCE1,025:.(1&'-9<;;7@?67&6=@D=:5=C=9;?D@A:.8=;;8:5=AA::9420?53AB@;.0++&((0&.#&$+-&'&&+%6':=?A<<9:;/-- +@SRR11410539.882140 882140/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGGTCGACAGCACCTAGGTCTTCCTTGCCATGAGTGAGAGCGGTGAACAAGACGCAGTATTAGGTAAACCTTGGGGCCGACGTTGTTTTGATCGCCCCACTGCGTTCTCCATTCTGGTTGCCAGTTGAATCTGAGGTCCACCAAACGTAATGCGGGTGCATTTCGCTGATTTTGGGGTCCATTATCCAGACATTTTAGTTTGTTCGTTTAGATGAAATCTAAAACAACACGAACGTCGATACTCTAAAAGAGTCTTCATAGAACGAACAACGCACTACAAGACTACCCAATTTAGGTTCCTGGCAATTAATTGTAAAAGGTAAACAGGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACGTAACT ++ +636785589<=>H;1(.'0686C@>A?>F@@9EHFIK35:8:7>=?<-;@@6,&(%/4583B<CB>C<65??B>?(0.BCCB6.+)765*+16C5<=338=:<?9=57'(###$$,2AEH=<E5:4<LB@?@ACCHI=FBB<>>9>,GGPH=@AA?=F65;8?AC?<0-3*)1;<9?A=689::410%588998C<?723215<;;$&.AACBDEMI>>=A::4.-%')67:?:<>B%%5216BCJIF;2?ECB>><B@EE?22@=973E;<1<?CD900;H@??=?950''/)+3>2EH;)&%('%$*9018;9?543+6676775%);:=>CFAD??77:>;=EAAGLF38A;639:;A7778;=>?:&,0558>>***>?:;>B@GF:;:<IHB77;,(833B;8@ACIHKE<>BBHDOJCABADB@<4/)1B/09=@=BEB>BCAB?AC?HFK<1;/8964:>C@@?;<<988&*BDF==8/$, +@SRR11410539.107949 107949/1 +GTTGTACTTCGATTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACTAAACAAATCGACAGCACCTAGCACATCACTACGCAACTTTAGATACATTTCTTTATTTAACAAAAGGTGCACAGCGCAGCATTTAAAGTACTAAAGGAAACACCATTAAAGACTACACGTCTCTTTAGGTAATTACTAAAGAACCAATAAATGCTTTGTGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGTACTAGGTGTGAACATAACCATCCACTGAATATGTGTAAAAAGAAACATCATTAGTAAGATAAAATGTCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATGAGTAAACTGGTGTTAAACGAATACAATTGAATGACATAAGGAATAGTAGAAAAACATTAAAGGCAGCTTCATGACTGTATTCACCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTACTTAATACATAACT ++ +.019==:;;.)'8.4.7,.)*%/%022,400*;A=AEJ@D?@==88'&&&23'-$&''1000--*5:;;@67>?F>B1DCBA//87-../$%*$$;=AADCMLC9BA:01278-''=D750/0-/-)'$$%'('01,(2..155%')%')$546=BA>@57</.1-*88:=:=>>3''.4595:B>CCH89;A2753/%)/+$%13;-=123571/<?BGF??@@=??/<4648267:((7@3<0$43*()'&&*/+.77<<@397344,,9@=3<,2*1''8.2=?A,(%1268C>A6.3602&&)>989><740=57357544,/.2=8332:6;H=69401032?>>'(*BB24/('&(&54117(66(*(,%&*010%'%)33;;;;9''*,12/0.-+()$,,*(&$%$&))(',('##$&)/482=B=<66@G43:=>5<<21>69??EFA68<LJL>6=97500=7999+)(%&%('$$$8950.%'$'"# +@SRR11410539.2225744 2225744/1 +CGGTGCTGCTTCGTTCGGTTACGGCCCGCTAAGTTCAGCAGACGACTACAAACGGAATCGACAGCACCTACACAGACCATTCCGACAGCGATGACAATATTGGCACGGCGCGCAGTAAGTGACAACAGATGTTTCGTCTGTTGAAGCAAGGTTACTATAGCAGAGATATTACTAGTATTATGAGGACTTTTAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAGAAATTTATCTAAGTCACTAACTGAGAATAAATATTTTCTCCAATTAGATGAAGAACAACAAATGAGATTGATTAAGCGAACGCAGTATTGCTTTTCTGTAGCGCAGTAACGCTCGCTGCTTGCTGACTTTATCACTACCAAGAGTGTGTTAGAGTACAACAGTCACTTTAAAGAACCTTGCTCTTCTGGAACATACGAGGCA ++ +'$'0%"*$')+12=0<%*57/3&'+++%$('(+6-((%/++*%=A=@8ACEE=3:-4<==HCHDECIG7---/''434*,1%)'%%&%)'%41&6;5++:8+(('&(.2*&'*%.89=>B=;)''537<66BA1*$$&%%+.+'&#(%&/6::14542/2,0('*($#$)-%46-6//2>@7;=CG=OJC=5645:I69@ACI@A8=67/-'&(39<95-)*13(/-3?@?DFD<55($(.6<@G>7A9C:6<<E8=EC;@>=<(:759<5487:2',%@;<<3%%+6677-.&.$$$+,*..+&(AB??@B23',,*12()&$(&-5%&&&'(%&%($%$#%&$'%%$#%')*,5'''(%#$*(28:1'**&+034600/(4735=A6/-')&%&&'(%%%#$%&''$)$/*%:;:??GLCLC>(-1**08770-)+.-# +@SRR11410539.1312277 1312277/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAAGACGACTACAAACGGAATCGACAGCACCTTTGCCTTGGTGATATTGCTGCTAGAGACCTCATTGTGCACCAAAGTTTAACGGCCTTACTGTTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGAGTGCTACACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTACCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAAATGCAAGCTTTAAAGCACGCTTGTTAAACAACTTAGCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAACCATCAAC ++ +$&#$)--:;=<>C//(;?CECECBDC87***3BPI??4+&&*./>BD==B<AB7>:=;@=>?D9B6DG9;BA>6)))0*02871+%*=>?:969/.-A?@F4--1892+)'*)+3/@CI??=*0FEHJC?@C:9=;1)4+))&-9<449>=92352,-?EA><@D@ACB=>634:89<>??9-,EABBA?@;>?<CBEH=@C>B@>=9<-08:8'+.27+,:59=76=B20.$$$$&,=A@;=@BAM>E@>520,--9473;==00,,%*0//8),+/-/725'?FF?<C/H+BI@CGEC<;B>=<>*BE?@MJ<:?>@<<=4-62();>FCEHF?@7>>>;<F>GC789@A>D>(>A@>B@B=?>@ABAH=9951E-B;34JHA?=@@=@%+;;9:,>%(.9:312.6934/844%,+*',662@AA:/0(%,+.('DDDJGGMHHBE>>11,:)@45+963)/87:,,:;9;6;:;=ACA;>93?;A><580-.+,-)*))%(((*(() +@SRR11410539.1199462 1199462/1 +GATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGATTACCAGAAGCAGCGTGCATAGCAGGGTCAGCAGCATACACAAGTAATTCCTTAAACTAAGTCTAGAGCTATGTGGTTTACATCCTGATTATGTACAACACCTAGCTCTCTGAAGTGGTATCAGTTGAGCTACAGTAGGACACCATCAACAAATATTTTCTCCACTAGTGGTCCAAAACTTGTAAGTGGAACCTGTAGAAAATCAAACGTGGTTACTGTGCAGAATGCATCTGTCATCCAAACAGTTAACACAATTTGGGTGGTATGTCTGATCCCAATATTTAAAATAATAACGGTCAAAGAAGTTTTAACCTCTCTTCCGTGAAGTCATATTTTAACAAATCCCACTTAATGTAAGGCTTTGTTAAGTCAGTGTCAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&$-&$$.4569<6(%+/594,4,67:;A;;1JKIFH575<5;3/55178:1:696488><72565643943100'8;;:9=56/874CDF<<:74931<639+54@BDBF@@(@@=DAA@>9:;=?A235@B;998<7/2<7.$$-%)(-;=?A$$*.43AB902;5@41..0.8<2DF:A=.&&%,/$%&(&)(-%+*)%,-&%+%%%(+)('+-2)?:;=EFC?ALJNC:6$&$#0539(),)+5773@CD9:*+2A583%%'&(.*)3&/*&&&('%'2'-4/%%$$&(7;<8F<=D>;C;:9:8--:<=2?>A?>=99@;=?>CL<@;1&'&;=6/A)))8<AEABA@DC534;B4)*%CFA>C;@<=((*&99:CC897991,<KC9;4+7(5<;@BBCD?>:;<7IID>AFC98?@FGA@967/4CHGI?>C8:536/:F92?:;<87()958=>;?@EJC:;;FBB@GFE<A?=@>A?AFEF<760)((42..;;:8/$( +@SRR11410539.1713237 1713237/1 +CAAATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAGAATCGACAGCACCTGAACAAAGACCATTGAGTACTCTGGACTAAAACTAAAGTGAAGTCAAAAATTGTGAGTAACAACCAGTGGTGTGTACCCTTGATTGTTCTTTTCTGCACTTTGGAAAGTTAACACCTGAGCATTGTCTAACAACATCAAAAGGTGTAAATTCATCTTCTAATAAGCACTACCCAATATGGTACGTCCATTCATACCATTTTGCAGTAATTCTTTTAATGAAGCACACCTCTAAAACGGCAATTCCAGTTTGAGCAGAAAGAGGTCTAGTATGTCAACATGGTCTTGTGTTAGAGGTTCATAATTGTACTTCATAGCCACAAAGGTTAAGAGTCATTAAGAGTTGTGGTAAATCGATTGGCTACCTGTCTCCATTTATAACAGCAGCGTACAACCAAGCTAAAGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +.&&$$&,074459:@12,55832200/19;A776DA=-/0+$('365=>44;4$+(/,;62.?:A4=DH<E>>E@::89?A=120)(*98;;?9BEGA?@C?9$,:<6.?@A?95FIJADECH=3/19<>:;34CCB@?45>@DE=:DB?>?ADSHAD<3;;;.'.8:>>DDC=?;=/)%,69:7@@@<;06---<59<..800?,&6FH-%+:9:.,/23*5-=8A.;,@B@??04,'(&&//**3;87:52:<<?AB??E:89CA>>>@A;837B;=;>?TMJD@BBE@.?B<53%(&&%15B<A=><8;24*/&*39FDD=6;4=>.*$4+%?(9+@@AA:?79?>@<>8:EGBECA<>33<??@E?<7871'&$&+.7.13/56EBCB+.28511#)%'$,&(78.%120.045424<<?=;<;$$#$6;:CB;<F8;>=;C9901307;;;-@AA<;=ME9:0:9DE(7*;==>>?<8A1124=ANHJ@5>/-<:>A?@69===;@=93/06687C?;,,%%( +@SRR11410539.589692 589692/1 +CAGTAGTAGCTACGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAACCAAAAACTTGTCCATTAGCACACAATGGAAAACTAATGGGTGGTTTATGTGATTTACAATAATAGCTCATACCTCCTAAGTAAAGTTGAGTCCCTCTGTGACATCACAACCTGGGCATTGCAAACATACGGATTAACAGACAAGACTAATTTATGTGATGTTGATATGACATGGTCGTAACAGCATTTACAACATAAGAGAATGGTCTACGTATGCAAGCACCACATCTTAATGAAGTCTGTGAATTGCAAAGAACACAAGCCCCAACAGCCTGTAAGACTGTATGCGAGATGTGTATAGCCTCATAAAACTCAGGTTCCCAATACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATGTCTAACGCCTTGTCCTGTTAACTCAAGGTGCTGTCGATTCCGTTTGTGATCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'#&%$(,-/2448:C3<&.=?@>=>ADE>>9;:6@IH=?1:685576@A=7:92,357:87?B@B?DEC1@JKCAKNE@:BIJ@?AA6575459:EIDDB=?/79773*+-**4=6<KI@@>?@?@GEC>?<<89;3;.<4>=@;79>*-;;<=;6743A:<1978?=99<34=7<<:::A33<;?2+1'89B<BFHG=>DHGGLFGE@A>=9E?EG?CAB;<;=GI<=@?CD@CEECA@BC;:9@>@;;33;;7857:<97??::*99/081%6@:;==>@8;8@>57>78:G@@@?@C>?J?AFC>B8635759;;:AG8>?@&0+<?@?4612:98)*+7'888>AAC:=8:5&%%(*2$0&9/0/*5?B8:;>><:@CHC@4=;<DM@<@JHIGADCAA@;5ACE;?EBCBFC8BBAB<@<:??A?>=D@A@9:.(4)$%%%##&-244>A?A@56:8@561=><?B?<AEFSG?@=G@:48&&3:6=@D=>>BBC?8;4=)/66442'&#%" +@SRR11410539.2193694 2193694/1 +GTTGTACTTCCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTACCACTAGTAGATACACAAACACCAGCTTCTGATCTTTCACAAGTGCCGTGCCTACAGTACTCAGAATCAAAAGTTATTTACCACTCTAACAGAACCTTCAAGGTAGGTGTTAGGAAATTGAATAATAGAGCCATCCATGAGCACATAACGTGTGTCAGGGCGTAAACTTTCATAAGCAACAGAACCTTCTAGTACATTGGTATCATAACAATATGGTACTGGCTTACCAGAAGCATCTTTAAAATTGTACATTCAATAAAACACAAGCTGATGTTGCAAGATCAGTGTACTCTATAAGTTTTGATGGTGTGTAACAGATGTTACCAACTGCACTAAAAACTCTAGGTAAGAAGTAAAAGTCACCATTAGTTGTGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTATATCAT ++ +(/0856===')66A0<4?C=7A<EGFH:87//0>D<AC?94545111595:84/(*<2;=645679@@4)6;>;932/**.*+/457967:::<4//4/,)+.0:?8A88953>:960@9?>?C7>5@@9><<97>78@A:69:3+?FD><>66:>90-+9ADK>?H7>=>EDCF?>CACD;=8+/33<<<DDBE>E;7?:=<;==86333.$-*,:;@?B<2,&99307?>BFH@ADF;6==<?;CEFDJDJI9:;<EB>@@E@>>>27G200*)12<=>@C=07:@<?36;;;74/=-@>1<EADPM>==1/056*&=7;<:)(#58>@A??BDE@?@;<;68/7--+,'7*.;<>CHG>DF?5667AIAA>>687;>>;1/081<5)@6+7544CCA?6%*JQMJ=?<E=>:A;-.$%$6>AB7.5<?E9:,,/(;(*7C:-*0.&&%-0;;@7788;:?>I<AAA<?1/>)$)/1()%$$(&(/'+%' +@SRR11410539.1550900 1550900/1 +CAATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAAGGCGACTAAACGGAATCGACAGCACCTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTGATAGCAGACAAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGGCAAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTAAAATTGCTGTCGATTCCGTTTGTAAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$#%$%-449;<>BI=81>DBGCBCHDH>=>3),:DFDF=>-.,%,(())02.1353;>>;8423)8<?>@337*..57CD8<E;??CD>61.+-47=>.+;=EDB3525@CCFDC9<C@CEEB@@<??BA?C:C<<454(69A$=EJF@**<52/2*+@B.359:29ABBG?>;%%<4<9=<GA?=;/>>*-++,6:EGBA>3:FEDGC-1@;:B33:FIIHFC<79,-(,$)&+((%0978A<=EDE<57::B=@B@4=@?=A@BBBB=:-/)<6854('&&(+;>>9::5*''':;@BGH2@19,6;;9@?C?ABDCAA;=>35>>C2=<B@,@/?A>GKEAB:5888EA67AC<=69-@FAIAFB<>@??E9BACC<64679-<98)$8:CACDA@=D<@=BB@FEFC-?)7,<2/((567('%%'/%#$7:;>67<?<=:;66:;EE>,,375>AA?::A68.(518B64*+&('/4677>BCABFAD<GA>45022>?:66B>>@?FH=A>8:.5660/=:<<=3, +@SRR11410539.1781029 1781029/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTACAGTCAGCTTATGTGTCAACCTATGCTGGTACTAAGATCAAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGGCCTGTAAAAACTCAAAACACTAGTTGCAACTGCAGGAAGCTGAACTTGCAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCAATGACCTTGGTGCTTGTATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +(,-7=;9<?<>N9>:<@B=@?BB:9*/-$&$8DBDI>>?=FABJABGBEF48(.(==?<==@=C@@=>>;7*2,921'11122335)$9&(77><$$&('%/')/&&2156-.89745959;87<7>::1439;4>8732;258:68?<>4>:@:>FF8B>>GECB?;918BED=JE<<DEF9DAM=BA?E127777743.$&$$%$'$*/11.38698::@8?>B?D>F???ID:366(,,/887::;;=:))$%&)0;<&&-%+ACC?HI>C>?=@DAF@=;==@>:?A/;=8<8;D8:&,6)*39>DHG>>???G>A@<710C:;=<DCBFJ48>B=EB,<<-1589AGKC::GIH=>BB=A>ECA8=9?=C:BE@F>EGEAA@<:B<A?B?>?2,665.02:<731<@BDAFCIBD=?>FF;/-9:9:@AA;>@5/''(((((1/,>A@A>B@A<GJ@A>>@@DCD<69;<BGFGC?A6AAJ<EBB=A73?8B@B>765430'13:966;76/.$% +@SRR11410539.192227 192227/1 +TGTTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTCATTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGAAGCTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGGAGAGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAGAGCTATGAATTGCAGACACCTTAGGTGCACACACAGCCGATTCCGGTTTGTAGTCGTCTGTTTAACCTTAGCAAACCACGTAAAC ++ +$%++*-+:?AB@K6:'-79>>7D?AF>?@660?OIFKH8B;AFBEBGEDDF7+%'+6>@=E9E2@F;:A5##$**+04.))'=C@@BC=<::-1,=.0+201@;=<A>9@>GJ?,&2%#$&$'&$111;=FCEH?45)''&134238=>((2(*@>=<9*:@DL>>330>IBD<<:ADE@?A<IKCDG?D7974=;>?FA;13565CGDBAC7>B=424++''''8;@04)*&,1%/2:>:545<8<<<,,>>;=57221$$,$$#&):;95;=;,(0.5+-+*0789;?B@B;DJEIIKDIH/8D?@B?B=?DBE=CHGDE<?ADH6/36:=55:DC=FGI-%?66;<'(8>?A2*-<=<;>?>CCACFI88JA??;@@:4;77*688HJIJ?BEGC?61,,.=FFIA899-234.6.>CFED9LE@;<<C5)>0A=DA@;;8B@?;<>8>7971'0+4()*$&&$%%%#*204:(,$*&)3146531)7<=AC@2..-.,/0$$#$(&'1311*,&( +@SRR11410539.424988 424988/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACAGGAATCGACAGCACCTATCACATAGACAACCAGGTGCGCTCAGGTCCTATTTTCACAAAATACTTCATAGATGTCAACTCAAAGCCATGTGCCCATAAGACAAATACGACTCTGTCAGAGATTTTTAAGTGTGTCACTTAACATTTGTACAATCTTTATACCTTTTCCCATTCCAAGGAAGTCCTTTGTACATAAGTGGTATGAGGTGTTTAAATTGATCTCCAGGCGGTGGTTTAGCACTAACTCTGGAAAAATCTGTATTATTAGGTGTATCAACATAACCTGTAGGTACAGCAACTAGGTTAACACCTGTAGAAAAACCTAGCTGTAAAGGTAAATTGGTACCAACAGTTTCTCTAGTAGCATGACACCCCTCGACATCGAAGCCAACGTCAATACACGTACATGTCTTATAGCTTCTTCGCGGGTGATAAACAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATATATTTT ++ +-***+)452,&6*80453)+)-.:@;ACCC(5;IIIL=?9:?@BA=<=9;9/'$..)6667..1004::2+3==?2/2-24*+$30;/B<<;F;:4>733/+4>;58*,,?A?E<=BGF@5498B4+'A:;=5,9;=3CBE>@=?CCC???ACD?FGE?=<:CAD=>:616(/86CCBA7577HE8B9A<))+BBD?CBG=;F=FG=?JI@70/&+&../$)7:>?&.+)/;34@<>B?EIC@EB=?=?@E=?BC=5285;;=B8,/47;A@=C@$@<G966=C<?KI:2--88:?B=B2?<@4<E?>9A<?B>AE>??@=9BFFB<D66@65%&+*-095:A?A:C59-.87<6@FD>>:<::B=6/.@>09634/'52*44AA/)65)),,/11+5((210+)*29,47)'-//25(/7145>:?<>AAB?852)./$$$$'('%0-,*+)5=DHGD>A?9?81'&%),,2BMIE=>=>@>CDADE@>>>$6=DCCC?:844;A7;<HD=,);86@74C:D>><::42126-0--.'##%%%% +@SRR11410539.1493037 1493037/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGACAACCAGCACCTACTAGCACTCTCCAGGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAACTTTGTAAGAATAATAATGAGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAACCCATTACTTTATGATCACCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAAGTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTGCCAGAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACATGCT ++ +++-$$$4579;B+-&06;=;8<8-0(7;?@)989885+&*&(6;?DFDBC97%*%+)+,-/47483CCBDF@HAB:599?$410;@>C@H9<../1?;::?,622=>EA@D<;9.,//13C12<:;<:II;<:5%/A;2C:<?HKH>>B?;GHA@IBBA789998741::8<:9CH=73;8?<@ED7</*-:;A==;;6.<>?@BD51-,-+>@;010;=F@A9;9DA:%,%%%'+$(89:<2;DKKLA??,-@C@?@<<8<:-7DEA9@?8<=>7966BB850%%#+3%%523*,H<;HHG?>A463)(--/&'&)'$*%/361:78::8;33@CA@6@==2''-')''',1-1/,%('/&13((+-,-535385;;A=<839%%7**)00292441;8?;:2*+.(22(=8B0A<*3B?B><7?CDA?-06<=72/0-1407<11=<2**&*$$23221$$#"$ +@SRR11410539.103412 103412/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGGAATCGACAGCACCTAATTTGGAAGAAGCTTAAGGTATGTAGAATCTCTCAAAGTGCCGGCTACCCAGTTTCTGTTTCTTCACCTGATACTGTTACAGCATTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATGAAAATTTCTTAAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAGAGTGTTTACAACAGTAGACAACATTAACATAC ++ +$*+-;:=?@99I5;79<DFD=GD@A=D@443?AEEHB>=>?C?=;465')&.)46:<B>D;DIECCAB>>D&(?D<A2-(((.-)*)(''$&%'%59>31>GH?;D<<3%)',*&=53<;E?B@>@<F;GB@?DA?;?/'8==@==884.%%)&6:=@588:@;<B>6-.4:A<.@>:,?BHHEC@9111,4<=;?@D-$$'7%1@7/?AB>5//=:66E79@?%&8@=CG9999@9:'')C=<:@>;=;17897:CD;>01;1=,.32,%'&'*37?===*+5(36B@@:GJ>45FCCDBA;604@@;;278:77;><;=?AA@A67>=<D??C@;<A@>@88>A<?J>?<=HGFBEE:<BBHI4(240&6:?<@DF<MICC<103974::9=BB=AC:/;*)9@@??;5500)%8=F@FB..<,,.%$%-'(& +@SRR11410539.2448562 2448562/1 +TGATAGCCGCTACGTTCAGTTACATTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCTTTCTGAACAAAGACCATTAATTACTGGACTAAAACTAAAGTGAAGTCAAAATTGAGTAACAACCAGTGGTGTGTACCCTTGATTGTTCTTTTCACTGCACTTTGAAGAAGTAACACCTAAAGAGCATTTATCTGCTAGCATCAAAAGGTGTAAATTCATCTTCTAATAAAGCACTGCAATATGGTACGTGTTCATACCATTTTGCAGTAATTCTTTTAATGAGCACACATATCTGAACGACATGATTCCAGTTTCAGGCAGAAAAGGTCCTAGTATGTCAACATGGTCTTGTGTTAAGGGTTATAATTGTACTTCATAGCCACAAGGTTAAAGTCATTAAGAGTTGTGGCCAAATCAGTTAATACCTGTCTCCATTTATAACAGCAGCGTACAACCAAGCTAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACAGCGGCTACGTATAAC ++ +&(&('%%%$(6'74?,.&&,,%&$$&%')+2978+?86))%&(('059=@A=<=7*(/+$$&$%($&'''4-89>5;<3/=57024%'$))&&020..379B;:=>09DEA4?:>DE<A0,:+86;;>;<B58*<9>;<<>BB=>44=?:83&19:<BIEAD@GF@A<BD::23(.$,+6883/'-$&$%$(,%%%$%++*$''+%.642<<82(<@?F<@GGI?@;A@0A.>@9:<201+&(->?<1-*+,&#$$*$%&+0**99>AENK;>6<:*+*679753;=5--14.*::AG5.7&'&&%%$$%#$%'1%62=99/$%%%,((.+)&,3'')-**/)$+'?78:9%&.<=CC>=@?<))5(6(&%+&)'//'.345=9>A44334/0(GHF=>.(:;+27/0:6DAB<;*($$245.-%%%+&+,1-/5<<>E9=777/.8<=8758+A:48.348-;;=B>BBC/1>D::;73C<?CA15<?@B5647:=>>B?@<;:,(('$%$%###+())(##$ +@SRR11410539.1987503 1987503/1 +CAGTAATGCTTCGTTCAGTTACACAAGGTTAAACAGACGACTACAAGCGAATCGACAGCGCACCTTGGTGAACAGTCATGTAGTTGCCTTTAATACTTTTACTATTTCACTTATGTCATTCACTGTACTCTGTTTATTTCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTGACATTTTATCTTACTAATGATGTTTCTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCGTTTTCATTGTTCTTTAGTATTACCTAAGAGACGTGTAGTCTTCCAATGGTGTTTCCTTTAGTACTTGAAGAAACACTGTGTTTACCTTTTTATTAGAAATAAAAATGTATCTAAAGTTGCGTAGTGATGTGCTAGGTGTTTGTCGATTCCAGTTTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +-&*(%%(&01475HD/&)412025000?CA>>,=<=>>A94-*+,-*-%$(.2540%2&4<?>>8899-9''%#(.09;<:5?=,2456>:<@8955?A<-,-''((7'%),;11/3599<33.($$$:;>:>9-)$&%)'5-0706;5;;:=<5>@AF;>?EDF=FE@>;65*57;=73632.(&3;>@B<=JEA=@@:62/4899;I@GDB8;76@8:;=C@FDEDDB48=;<BB:<BA89::9+*2::=@BA?;<:97247579:?>BC=CB<?;;AHFGD<>;@>C6C;66?/2/.::.),&))+-%%*,'&)&,/,0(-)*-4773*,%0;>><A@2-88:B@01686*0;=<;F;;89;99;:,,/54204.''#"&$)$'(()+,,---*)-.1%,20/>?6)?58B:7<;56''-=>GF:>9@>44-2''+/,0.-+,+1974.20%'$'$)+&3990*</BAAB===?<;;7:>=2?>;:0.' +@SRR11410539.1032430 1032430/1 +CAATGTACTTCGTTCAATTGACGTTCGCTAAGTTCAAACAGACGACTACAACGGAATCGACAGCACACTCAGCAACTGTTTGTGGACCTAAAAGAAAGTCTGCCTAATTTGGTTAAAAACTCAGAATGTGTATTAATTATTTTCAATGGTTTAACGAGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCTTTCCCAACAATTTGTAGAACATTGCCTGACACTACTGATCAACATCTTGATCCACAGACACTTGAGATTCTTGACATTTACACCCTTGTTCTTTAATTTAGTGTCAATTATATTTTCAGGAACAAATGCACTAGCAGGTTGCTGTTCTTTATCGGGGTGTTAGCTGCACAGGGGGTCCTAGCTATTCGGCGGATCAACTTACTCCACCCAGCGTATTTATTCATACGGGTTCTAAAAGCAAACAGGCATTGCAGGCTGTTTAATAGGGGCTGAGGTGCAATGCGATTTCGTTTTTGTAGTCGTCTGTTTAACCCAGCGCAATACATAAC ++ ++%&##%(*-209C=7%&%%%$,(.-$#$)'''(-%&++32438++)'%%)).,//4982.&$++*-'$(,$*+''&03243'%489.-+@C:'$&&$)%11'(%%366=6*+6<,,*-3685...=$$)%$$%)%%+.&%&%*(8;B;=DG>113(('%#$%+-C:E=@@=330212,<,::8==61/5??<89*$&'*,..''46646*(%14+--.,0%0&2356588:;4++%$''%%(&(.;<78A12117-477;;89@ED?PB?::<:;?:=10/%&(29:650+,-*..)(@727$'#)+()'('&+%1=9B>:;8''(00*("%$%6;;&'939959?=73<%*6/.0*+'(()&%%$(&*((/..1*'$*51><4$()%'&22**++('(3/*&'''./&)0-:;:::7(&%%4%.>61*$()(($$%'&*,%*2001<97@>;@DGG@56737:BB@87-*4C<<55+)77357$($+-,(('%,.9;:669:;<1&&$(&&#$$'01,('$&''' +@SRR11410539.49493 49493/1 +CGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACAGGTTCGCGACAGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGATATTATCAGAGGCACGTCAACATCTTAAATTGGCACTTGGCGGGCTTAGTAGAAGTTGAAAAAAAGGCGTTTTGCCTCAACTAGACAGCCCTATGTGTTCATCAAACGCGTTCGGATGTGAACTGCACCTCGTGGTCATATTCATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGGAGACACTTGGTGTCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTGCGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTGCGGG ++ +$%%%%%'$$%/$#(&(./,20/4?><BC-DFDAD672436?@970846)1&+.889BB>:BBD<=C?CD?@H>=*BEIFF>5,/%(&'22;9+*/)72B4<>?BA98<5;>=3=A>77,2'+$%$$..33/2(.0=9)?2/A45=2=CC<'(''./4==<==1-&,047799>:D;@6@B>78A=7.'%&28CJBBC@C@<A.,'$$%-+*+:;:9:7:BBDDF92EDE>7&8:A);-.;3&$%&#%&'--4403%',/,7*$%()$58<?:CE@KCC=>15+($&'6<;>97?AA??A:?9?@DHBA7<44546,.4+'70(77844>,&1*:9=>B?;8>;>7DCHB**>C<<C1+1;;>78:>@?(<63+AEA>JA6BBC<A=?3KDD79BAEAHI-=99)BBAADBDA;42..&,%8.0<>>;74230:<11<C224@G?>@BDFB8B42/-/33368?@@=55&&.&$%$&% +@SRR11410539.844846 844846/1 +CAGTATTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTAAACAGGAATCGACAGCACCTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCCCTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGAGGTTTAAATGGTTACACTGTAGAGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGGAACCTTAGCCATCCCGCTA ++ +(&(%%$'%-.-1:D/=7=DB;<;4001=@BEE(.FIHILB@<><7322'=>6*&,7,.779?5=3=?AAF93//BB@AFB?>4;=507:962+/7=BAB>==@=:9=((=((:B8F<,+%-/.'+)1%,88:668%A3E1A675;C?JE:?<G?>;;--:77:74+))/56:=9+;>;@?88DA>7?AGLH5'7@B;,/?;;;D@DB@;F45G;?BB@A>//:9LCDD973..)(9878$%5<9@<.0,3:7;?ADDG@:<?DAFC./;87:32$0<KIEAD@?9=(-33B=??4:/0'(0'.,-%%,.62>7223BCD1+7B8@CDF96II=@?==::@CCA:::::85.-903?<>A>.77692.2864$%37;ACCALG@BFB>DBEEKBKDCDH@?=@<1-.*,/.*').+549<..996=?:DIB@<;<B:;:?B==BB==G<45*&+':13-/.616+.''29@>@@08:>?<EDI@8<<;?7071)+.&*-))(#$$(%%83##($ +@SRR11410539.187077 187077/1 +GTTGTACTTCGTTCAGTTACGTATTACTAGGTTAAACAGACTGACTACAAGCAAATCGACAGCACCTTGTGTGTACAAAAGCTGCCATATTGCAACAAGATTTGCTGCATTAGTTAGTCACCACAAATGTACATTGTACAATCTACTGATGTCTTGGTCATAGACACTGGTAGAATTTCTGTGGTAACACTAATAGTAAAATTTGTGGGTATGGCAATAGAGTTATTAAGTAAAGCAACTGAATTTTCTGCACCAAGTGACATAGTGTAGGCAATGATGGATTGACTAGCCACACTACGTGCCCGCCGAGGAGAATTAGTCTGAGTCTGATAACTAGCGCATATACCTGCACCAATGGATATGCACTCATATGAGTTGGTGACATGTTCAGCCCTATTAAACAGCCTGCGTGTTTGAGGTGCCGCATCGTTCCGTTTGTAGTCGTCTATTTGGCCTTAACCAATGTAACT ++ +%/12:;;?A;;E?:69<@=>8930/+952.(DB<><2./+'%2.-3&'14$;:;6/3.175>CF<=?=+*%'/0-37:9,%6:BAB=877>-;*)5(*%$%,-$&(%*%''%,-/$%+)&&&.079:8;:>C=>B:<=8:;77=5ADDFF;>A>9%%)$,3,+A;C>@@A3=(@:::B>;55-/0)))0./9:7.>@DI7CCEJ@@9<B@@G?@D>A>;:=??9:13$$&,)+&#%&&%6995PLJFG:85343&();<9:137/712,-.4..4544-0(00-(%+1&)'$)&'&%%&)&158=>>B>3.7,<>:<6<3>16/6.<(3-)+*&(,-:>?<5;2388:994<=10,(*&%%*&'.:@=:65,%#,94(*/.-6677>=9;485+'((,?@<7:/()()+8A@>B<;---,&%&$,*'*%')'.19>E<>3459572%%))(#$#%$'''$'#%%$%(%%( +@SRR11410539.2448953 2448953/1 +CATTGTACTTCGTTCCCCAGCGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGGAATTTGGTGCCACTTCTGCTAACTCTTCAACCTGAAGAAGAGCAGAAGAAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTACAATGCGAACATTGTGGAAGAAACTAAAAGGTAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAATACGGCTGTAATGCCATGCAAGT ++ +$%'(*(/++,',/2'(''$'-22203226000AIGJMD>56:<:7;:6875)5%)&'.<;D=C<D9A@D;>A8@CE8;C>@@,)<;8924:**87??@C;<GEGHHG242*1-11,97%6-$/,,3:<HE;<AA//CABEHG>C66DHJCCEB??297<<>=CEF<A7>@9<7727;BDG@72,-0,,.=@<9/3-,*+-1E;=;I=?<33%9;>C..<=4>444449,,77;=8;5BC=<?=CFCHD2:916:AA<5411(-3CHHI@AEGEJ>89%<=MG=>??@B:=>@?7;@@7/;=..&$)$&%$%('.@//0,%-2+-..,$%'440&(0512*'(57,&0,%**+.17?A772;236>?;<B>5**+*+78&,'**/2=2+*9>?25/1,,2%,(+%%&&$$#%$*'%&$$&$&+2%&&$%&, +@SRR11410539.2111921 2111921/1 +CATTGTACTTCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTGAGGTTGCGCTGTGAGGACATAGTCACATGCAAGAAGACACACCATGAGGTGCTGACTGAGGAAGGACATAAGATAGTAGCCCTTTCCACAAAAATCAACTCTTTTGATTGTCCAAGTACACACTCTGACATTTTAGTAGCAGCAAGATTAAGCAGAAGCTCTGATTTCTGCAGCTCTAATTAATTGTTGAGTCACACATGTGTCTGCAAGCTTTGAAGTCTGCCTGTGATCAACCTATCAATTTGCACTTCAGCCTCAACTTTGTCAAGACGTGAAGGATATCATTTAAAACGCGAAATTGCACCAAAATTGGAGCTAAGTTGTTTAACAAGCGTGTTTAAACGTACATTTGGTTGACCACATCTTGAAGTTTTCCAAGTGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTGCTCTCCCCGTAACA ++ +%$&'$.(**/$%6<6>6?DAC;<@FAA:A=--1>BB;>;:::812'),%%68:1))055374?>@4<<*%#'-%'$'%'-(&'$')&$$%&)('$$2/+,-++*)90%3%?BCE??8=B@BBBFE;791)&+,'05>5;89A;4&&24/00..:E<?DANM=A+%;;<@DHGNLA@<9B89:A;<7D;$>ACE9A7BBADHEM<93A;A;B6@DDEA85-,$'&&)));<7?BBOKI@?=>EAD4?1EGJI6768<>14'82>;(6:1-/+09<?6=79(<=>6:02567A<@@@9;>3.?,,BBE=8<=@=@N@?,9:?.9'??;>+++<<=3)=/0/:817:69*AA5:>;)):?===22$$(*068A9?87>><;,,18:3:>)CDDACAFGB::=ED<>=?A564%'(*&&$1148:26/5@A>AC=:=?D:@5=?<CRK5==<7FE??;?;@B=;7=:;EE<@?C@EAGHD>@>?B=?DFDCE<1+($%).;<;.$&&''' +@SRR11410539.261583 261583/1 +CATTGCCTTCGTTCAGTTGCATGCTAGATTAACGGGCGGCTACAAACAGAATCGACATAGCACTAGCAAATATTGGACTGAGACGGCCTTACTAAAGGACCTCCTTGAAATTTGCTCTCAACATACAATGCTAGTTAAACAGGAGTGATGATTATGTGTACCTTCTTACCCAGATCCATCAAGAATCCTAGGGAGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATGAACAGTTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCTAATCAGGAAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +%%()#$&(%'&40)$)%)%4-.+12/+$''&%&&**0#%$(()-1333213540+&%%&#)-,%0$*3552268?AE?;?7:,%%&569??@?IN1:@<89>%.),,4:<CGO=CG@BC::BD@=;BB88<B?BG<<@?B?>9$6<33;<:>:442/)&%587+;$('%2'5'>9;A4.@;-4<>--2-&&&%&%&(36;AB=?QI:>FBBF@@E;7>:9?@98':22?=34;301--095%%7659)';598<7F??AQG69-.9?>E;HE@;H;0FFJ:9AIECCHI>41->/@A@>:94-$.06<<B@G@E:45>=D@7:<C;<?:?A@A::8&.9<9:@ID/CAEGEA?=:3)*(5<:9384>GA6@=)*(-484=B>CDDAAFEFC@AAC;CHG?::?858635/6:>3C89<B@?=A6:;0/+,*+)AEAME?76(9;<37-9?@A@9663337?B??@GBD::9949C>A@>BAAFEC@67;==AFDB@14* +@SRR11410539.2339632 2339632/1 +GTTGTACTTCGTTCAGTTGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACCACAGCGGATGGACTTACCCTCTTGAACAGCATCACCTATATCTAGACATCTTTCTTTAAGAAAGTGATGTCAATGTCACCTAACAAGAGTGGCAGAATCTGGATGAAGATTGCCATTAATGTCAATATAAAGTAACAAGTTTTCTGTGAACTTAGTTTCTTCCAGAGTTGTTGTAACTTCTTCAACACAAGCTTTGATTTTCTTATCATCTTGTTTTCTCTGTTCAACTGAAGGTTTACTTTCCAGTTATAAATAACTTAACTTCCTCTTTAGGAATCTCAGCGATCTTTTGTTCAACTTGCTTTTCACTCTTCATTTCAAAAGCTTGAAACAAGTTTGTCATAGAGATTTTATCAAAGACAGCTAAGTAGACATTTGTGCGAAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCGCTAGCAATTTGGC ++ +&''%$%%%)(6@+9157*'*&'+7<A23/B:8999@?BC@EEBB@8::66)/388><A.)9::DAH3+)1)*'*%+%&$)4''%(<=CC?<>;;@+E(=72;20*+*$$#%%%-)5;<>;A=9BF=;<4:53.FADE/*804:?=CFF%?ABA;;2./GAECKBBE;>A67<>DA;BCCK<;<>IHBB;<8??CFE@JO62C67B12=16OGEA?998/=BBEDFIMCJB.7F<40=:%9><=333A@;A6?@A>E@BA5BEFFCDEHCC@FEC<:<:<97:58HF<CC=AHID00/23087:?@=;8:;A)0:=HFD?-.%%#$''*:;:A:,-58>;FEGIE@9?0>>>6((8?A@@A=?>>:;22434@AF@@72;AFDDBED+;KP?0D<<;?6AA=@74>?M>9A6.'4''<GIJE72A=>7<CD<<@7FFB@66F>?DEJ5A<4..,$.?A=BC=9;<;E?CD9@=421/9;/+=,?=<6--,2%&)*%*$$#"%#$$ +@SRR11410539.2467772 2467772/1 +GTTGTACTTCGGTTCAGTTACGTATTGCTAAGGTTAAACAAGACGACTACAAACGGAATCGACAGCACCTCATCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAAGTGTCTATATAGTAGGTGATCATTGTTCCAAGAGGGAATGTTTCAACTACTATGAGTTTATACCTACTAAAGGCTGGTGGCACTACTGAAGTACTGGCAAAAAGCTTTGAAAAGTGCCAGCAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAACAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCCTGTCTGTGGAAACTAGGTGCTGTCAGAGATTCCGTTTCAAGTCGTCTGTTTAACTGGCAATACGTAACTT ++ +(*+%&$++)&$&&&#&*44)(.<458??C@A/E=;44'+(('2-62/.%1+-;7',(4;979517>?=<J@-$A==?A@@AADGEHG?BF@B2)(+-,0,,08730,0(%&')###+,+&$%#%$%%%%$%)'$',--*('$&-,,-%,&'&'3%%%&/.88'%#$##$#%$&%#156,(&'1/'9759=/'-6:46<=>@D<==924)()149=-34.0*('*335453):9:D;9*A$41234$'$'$%%(+-5:++<=;DGA*/81B>B,A>@AADC<6;442-37=6:=:0(30'64354*9>9>F@;;:BCB6=C>?DLMB=87@@BAA=5@=DDC?A=>ABG<9''6=;??A?B=:@67;%:01572FFE@;9@BH,%??BCC(GFDE<BJJMABBH48>;.-15/&)))0,,786>77;B:61.)*&,88;33-,:;6649;417689;A<9=65@?.472*%%'02=@7:8:>3##$'*/*'9-2BA>;2++$*+-0./=>@53**. +@SRR11410539.2285457 2285457/1 +CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGAGAATCGACAGCACCTGGTACCAACAGCTTCTCTAGTAGCATGACACCCCTCGACATCGAAGCCAATCCATGCACGTACATGTCTTATAGCTTCTTCGCGGGTGATAAGCATATTAGGGTAACCATTAACTTGATAATTCATTTTAAAACCCATCATAGAGATGAGTCTTCTATAGGTCATGTCCTTAGGTATGCCAGGTATGTCAACACATAAACCTTCAGTTTTGAATTTAGTGTCAACACTGAGGTGTGTAGGTGCCTGTGTAGGATGTAACCCAGTGATTACCTTACTACAATCTTTAAAGAGTCTGTTACATTTTCAGCTTGCTAAAGTTGCACATTCCTACGTGGAATTTCAAGACTTGTAAATTACAGCTTGTCATAAAGGTCTCTATCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACACTTAGCAATCTATCTTTTA ++ +0%''$$#359=>E:2*-DECBACHCJ=<A51-=HGGIF4?8A<>;>?<312')&*2/899@;61/2;@<?BD?;B@111+6>@?D4;2626<=>=36.43>8<>C@<<83,*&(-?DB@C<?C@<?A=CEFDB5>?9;?>@19*'655=>E0@588:A@611(.+''41,3-3?@@;<=A@>>//0<7735FG?>678:@AE>+,-:<@=><<@CA*BDF=>>AEFD<C9A<?G@@78@9?992<A7787681<?;+$>9::?98:AE>>>>7A>B>ALB=>@DC=(+B94???>D?AD@A@?DCG73:-62=<>78;22=?B@BECACA9+.AB@A>8?;<=7:;?>CC>AAB=CD-1-64<9>G?BBBB?J18-,$&&#"+67/9--#**48>?;<B?77@;=;1@C/.9:61,01**(,--+$($.9;=>>A87AA7/E9:>=:62777*<@=6489?ACC@69=CCIE@CB<=;<?<6:73,+*&#$'&#&%&%%#$%$%%%%# +@SRR11410539.2124668 2124668/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAAAGAGGCCCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAATACTAATGGACCACTTAAAGTGGGTGGTGGTTGTGTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTGCACCATTATTATCAGCTGGTATTTTGGTGCTGACTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAATCTCTATGACAAACTTGTTTCAAGCTTTTGGAAATGAAGAGTGAAAAGGGATTTTTGTCGATTCCATTGCATGATTAATCCTACCTTAGCAATACGTAACT ++ +$,-/2313(45D2;3<A=4+%%$,..5913):(*,/31.0/50//2;9560,143556<;;:99:=?8>@6??A@A<B7,57@2BA:4/:+'+(*(*5620++&&'$)(*%%%*,2,,--&%%((%	<<@@<=B;>;?@B?>C>8=24--/<=,EGD78FBD::;<KLH8E;<:5*+$'*(2&+...).01<7<GBDGAA=?DF985*,)+&':@:;JE?867EG3*1$')))36@57KF:<?BA2$*0>;:<+GD4BC@009CFA=>356,7@)(CCCCB@>@D2BE<E=3-(.0230/.@>B>9%%.*37:<DCE<HH85-$(/,(,-<:;B<.5::9>HC>8:55B??@=KJ=();CIEEH=HHGEDAHG?DDC@@=@A>BC>=<;@DC:;HDFCDD;<HDIDA=9??:<7>A=?CC;CECCPP?GF;H?B9CGIPG11HMHGKKH9>8989>=&+)&#%&%+069=:BD:#('**&&$)'&#%',&&**$$%$&**+-.9;B>@>1&, +@SRR11410539.673633 673633/1 +CAGTATGCTTCGTTAGTTACGTATTGCTAAGGTTAAACGAACGACTACAAAACGGAATCGACAGCACCTCGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAGCGTGCCACTCCATGGCACTATTCTGACTCCAGACCGCTTCTAGAAAGTGAACTCGTAATCAGGGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTTGCTGTATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATGTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTCAACCTTAGCAATACGTAACT ++ +*#&&+**29@?=H?7=;A<:4B>AD?AE897DPLFI?,&%'*?DCG@?JKI>=:<?=>E:BDCGFEAAF9CDAQF@DH?A>6<;?BE7?1744@@6FNFBAGHHBDEDNHI=6@->>HB9:&&<,/%25;9/:1A@A<)*($%&49;@C<3--/*.@:9/93GEEH@IB><53,*%7-:;:2088&&2+2:99355:A@EMJ:CGFDGCAF@EHBC>B2+>**.427*+12>A>?-)<,-33<:;C:?<8>8%,4:>>>B>BF?EBEKKB???DGFFEIB>**/GADE=>?;@7716=:;@;>EKHE9*(C?;:1/)1/,57D=8A7;02<79EC7./4/',+2?::0<89D/*>)?DMA>CF<=ACA?@?88FEG<>?3@?>BB@==/4-54'/1-3@@3487$$(+*./100>@BGB838@<=<DELDKKAG?ICADEIB>:@@C;EADA?@G11--1)9&6>>CHB<@@GIB998HGC<89897)'9)*%%%10','))68;<?@DC;41#% +@SRR11410539.1516950 1516950/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCAGGAGATGCCACAACTGCTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCGCTGGCAATGCGTAGCT ++ +&02-/*;??=AM1@;>DCHA>HI=G=====.?GG=?932412'&&1+9AB8:%,$0574421>DBA@B=24-$;;;7?E4>09:67@B54BD<=BDCE;49?@?@MF9BEF@FFL92>566;==8<3>1200=@ADDEIKCEB?=FFJE?;@;6.4ABC7:>BE@DKFF>IGFFEHHAA<A<9988<:17:<9=;52&&-.5%&4:<=>;76.=?D=>KBFCC44<>FDG@;>D=:ABICBHD==@@IJH;>DFG<55EKGLC>>994<=:<F=?;:;=57,:?D=C79=@9:B:;A>:65;??IG>>AE89G<@A8@>D@<<5>43&(%%),-.57;:77>>?4?013<:>06+526CFCBC=6AB0:=?CJI;)*%%$%(,;75;@?8215*(:ABBB;@@44?;EC@@@81:5:=:7>=?;?9><8567;>A@?><3765D>=9;;<<%:@>:9?<33228@@><::;+-1='0*8879<=A?B?@FG?A<>BGE@A?9<?>DDAFD.%,$0&%&#'-..((6/)%%%% +@SRR11410539.565909 565909/1 +TGATATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAAATCGACAGCACCTACTCAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCGACTGAACTTGCAAAGAATGTGTCCTTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGTTTGTTGATTCGGATGTGAAACTAAAGATGTTGAATGTCTTAAATTGTCATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTGGCAATACGTAAC ++ +%,)'%&$7=<?:E9;6>B@;?=EEDE462(()/;<JME1=1<A4336079:&5&)'9:7:7D>D?>>-))/.-&%-$-/002-.(74F9:C@>922AFC=?A>5B-D=A<AHHGM=73?5<>=>ADAHF36=52*-)8-.3582:;D-<58;954,0++86*+)&%++,:D;KF><87A3=>G=>62E..AFFFD>>4178.9BB44<(1;+.,-523+469:5413:;F?>92,)%',327<:::/:D>)21@9<@@--7-/$%&&++,++;A?A71=522454311362),3.<C<<797<@7@>@H??@67=>8)-1)(+++8:==CE0/:;.E8AB@22>A?@>>77@<868<C49>EFMHF:,0(*0A@<3FF9:97=;4968((121BDAEA8<>BGB,=FAKC@014**(:;14JB:99@7783FGJ57BBA5:79:=<5334,,,022;A=:,2.35??>F<?:CE89::;;;?@65233564743%/:7:55D=9,/' +@SRR11410539.448279 448279/1 +CAATTGTACTTCGTTCCGGTTACGTATTGCTAAGGTTAAACGGGCGACTACAAACGGAATCGACAGCACCTAGGACTGGTATTGATTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAAACAGTACGAACCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAGAATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTTCTTTGACCGTTATTAGGTGCTATCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'$%$%-.-67548JG28279=98362669@:001=GA89;>%+&7/)-*%,68=D>?C@>?@F5.=>CFDEBDH?;:88.*$&)&*,25-->==3?<975?<;:;<?D<DBC?;>DGFFC//0//24>CBCFE?GA=;<.,.'(2667849=JJ988571554.$%&(*788A?I@F@C=*5936K;?DD8;BGHH>DD44??@7%'FGC?B=%%/36,$2/)&08:*6:?E<@@668;9=BDDC?QLJ@;=966HFEC954?DE9;/*;?AB?AC4:-?*.@C@'(B7>=BFEBA;?DEFEEA88<@9=D;ED>@9:;7798788<4+''))'%(65B@9IIDFD?EE;?:1::=85*))/294>5=<HF:=>;5::<9*22589B>?A@?:E57@4GLMEBBCF9J@:;A<;L?41057==);A44A==23(&((-679DGC>?<LC897.94<75-&0=@EOD=@;KGD.EGB<A>>A?C>>D?@?@>==99<<89D?<()' +@SRR11410539.2204217 2204217/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCTGGAATCGACAGCACCTCCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAGTGCAACAGGACTAAGCTCATTATTCTGTAATTTGACAGCAGAATTGGCCCCCTTAAAGCTGTTACAATAGAGGCCATGCTAAATTAGGTGAATTGTCCATACTAATTTCACTAAGTTGAACAATTTTACTATCTGCATCTACAACCTGTTGGATTTCCCACAATGCTGATGCATAAGTAAATGTTGTACCATCACACGTATTTTATATGTGTTATAGTCTGAGCTATGACAACCATTAGTTTGGCTGCTGTTGTAAGAGGTATTATGTTCAAGGGAACACAACCATCTCTTACCTGGTGTGCTGTCGGTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGC ++ +-/13)3+9:=<<M?;4<;=80(<6CF88=9:3ECBEI=<9<9::78.)&,-%$$$&%/,/2;8>23)44=412<;:;?B..:EBIK?FDEDA=>=@56G;>6650B::<=<=858./=8=7.,0/;<??;9@2(+6==>99,)BD<9ADFB;6=B@B>CBEIEJFC22'%;:@46<=,99A?BD=BB=CB??B>AFDB:8;<@94218(())*,''*?@=9@::CB2ABE+>'.0<>AB@DBDHG-?;66*,6&&&.7569?;?E@<>ABLDFEC>?;@??<=@AA794,77?@<AA4/*98:89@BDCF?;<>?;GEN=@>A?HHABAHFCIDGAD:;;A>AF56C@7=8;<@9>>$>=CIIFEJ@;>B:=D@CCGCG;39-/&&#.2;=9855:<2<933>EA'1=A:>FE9@A;%&7087FEDEDACD-4()>BA:@::;?>8,5>?E?>2&%$#$&'($+57<9>,-0053:<G8<F@>B<=@9:?@A880804,<;89966)' +@SRR11410539.1607713 1607713/1 +CATTGTACTTCGTTCGGTACGTATTGCTAAGGTTAAACCAAGACGACTACAAACTTAAATCGACAGCACCTACATTCTAACCATAGCTGAGAAATCGGGGCCATTTGTACAAGATTAATTATTAACCACATAAGCCAAGAATTACTAATAAAATGTGCTGCAAAAATAGCTGAAAAGCTCTGGAGTATGATTGCAGCCAATCCAAGTACATGAAACTTACAGTGAAAGAATATATGCCAAAAACCTCTGCAACTAAGCCAAAAGCAGTTAAATCCCATTTAAAGTGAAATGGTAATTTGTATAGTTTCTAAAGAAAGGATAGGTGTCTAAAGAATCTAAACCACTAAGACAAACACTTTACAAGGTAGAACCAGTACAGTATTAGGTTGCAATAGTGACAGCCTTCTCTGTAACCACGAAGGCTACAGTAAGAGAAGGCATGCCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTACAATACGCGTAAC ++ +#$((,30125;=E@>,+.-3+735476=<=3A>;770*7)*87=21*3<934+%&%%(589:85/..6::@A?8976*9<=>))*,;;A@*9>?:<*2A9868;=H@>:G>?=>;==?=?48<2232(-$$**&12&'+1..66@?CG?BC:<01.#$(&''((/.,'*-0(')%%&'((((,#,07:A66:++,$$$-.&&:7873-,0,+)))$%%$%&+34202(>C<@38,,4476,(')+-:?54%-9@=?=99@@<036;<EC>AC:<BC?FF>AA-'*/61??;=C<>>DI<:C@@<B>1;0FG,07(%@?B83=9A>:A8IS;+C?36:=?@@BFA>CEC?<89><@$$&542--+$').+A>?A;@9,'.)**039@:==?<<9745/-*#$%'+0,0263/--+)##'&&$%'*,.'2667,,+5+7;>793/-.00-0(<AA8:>AA5+0;CDLD?<:58899:9=9112%-%*$%$$1.101..&'$ +@SRR11410539.1812663 1812663/1 +GATGTCACTTCGTTCAGTTACGTGTTGCTAAGGTTAAACAGACGACCTAAACGGAATCGACAGCACCCTACACTATGCGGGCAGAAGGGTAGTAGAGCTAGACCAATAGCAAAGAATGACTCTTACCAGTACCAGGTGGTCCCTGGGTGTAGAATACTTTTGCATGTACCAACCTTTGATAATTTGCAACATTGCTAGAAAGACTATACAAGGATATTGAGTGTTGGGTATAGAAGCCAGTAATTCTAACATAGTGCTCTTGTGGCACTAGTGTAGGTACCTTAATGGCATTACTGTATGTGATGTCGGCACAAAATAATCACCAACATTTAATTTGTAAGTTATTGTACCTCAGTAAAACAACAGCATCACCATAGTCACCTTTTTCAAAGGGTGTACTCTCTATTTAATACTTTACTGTTTTTAGTTACGATAACCAGTAAGACATAATTTCGGTTAAAGTGGTAGTCTAGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTCTTTATAAC ++ +)%/&&$#$$&&%%'%#%62()#&$),58:24,:67;?AA>A<5)))$)#'02&)%(:<;C<A98:;=-+(12595++0%(0,)(-,---5167))&0826:178BE;=6745+%(..,.5:80.669:310/,&,8:*+++3/,&(+0&'&6';777<BEC.2+##$*A@00>C>B?:9C==EHI@C56>98<7624+,,)$%#$$$$&#&,8=40D/2&96696+,000+(%%,'97A9:=A::;77;D*;3<D=E>@AA;48::,,-'+4,+$''%$%'',88400.--046525;00<>@B=55$),,-..);<<B=?;88-.ACPNE352>D;<694;.$9<725775.%,.147?A889?87//6-)&68,,;9>:>??CI87.0&',-A/54?-4(:45:<8#%%%66;E??A<:<KGB9@B<507506<B@=@?67(=645//$12623;<*+')8,/)&,085<5@;B7);320%48:@A@:=>@AB3434870)1&&,1)((,$%$$# +@SRR11410539.2462459 2462459/1 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTCCTTTATCAGAACCAGCACCAAAATGTATAACTCTCATATTATAGGGTACAGCCTAATGTTAATGTGTTTAAATATTGACACAGTTGAGTATATTTTGCGACATTCATCATTATGCCTTTTTGGGTAATGTTGCACTATCACCATAATTTGAAGGTCACACTTTTCTAATAGCATTCTTTGCATTTTGTAAAGATTAGGCATAGCAACACCCGGTTGCCACGCTTGACTAGATTGTAATTTTGGGTAAAATGTTTCTACATGGCCATCTTTACACACCAAAGCATAAATGAAATTTCTGTATAGTCAATAGTCACTTTGACAACCCTTAGAAACTACAGATAATCTTGGGATTTTATTATTTCAACAAAATCATCAAGTAATAAATCAATAACAGAACACACACTTAGATGAACCTCTTTACGTTGCTGTCGATTCCGTTTGTAGATCGTCTGTTTAACCTTAGCAATACGTA ++ +(%%&,.-+,10321-(4@CC;=?I=B@D?-.2HMHDI>9,,/,/.+*3335:8+//210/42/13377A6>6::DE3.6@01@B4F+:?BBHHAC00179:<?A39?=DFF>@-9+:HA>B?CB%>74)>CDABDG@HBDHAEA==@DCD63;<<JCB9A=BEDF=:7('45:ABB?3.=9:=<=B=?::)%-%)0+13++2<.B:<0<6843586.1,3*-)(36-5>?C<<=>-7+9??CEAF?@?LGMBDCA@KIED>?*('<=,,;4(8<7;@959<@;78=GC?B>>6555.(#'%+$%->BEEB@A?/5=7131:23?C;=8424A;>B=@?BGFD>'>6:7@GIJ=:D>EG@=B@LLEBAB@?:/:790>AC=5:4=?569C:;6()54.-/++18156B==BD=AA<>86'(&&<CFD@EA89>>>-.;>?=A:?;9F9<;?:;5<>8-0%%$''*<)<942(,0&'++79:02++(+'&''&$%('+44B@9BCGCEAD8<8=++$%-&.3;?AE<<<>C@?=>C:AAB?>>8-' +@SRR11410539.2040419 2040419/1 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+GTTGTACTTCGTTCAGTTACGTGTGCTAAGGTTAAACAGACAGCTACAAACGGAATCGACAGCACCTTTTGCCTTGGTGATATTGTACGCTGGGGGCCTCATTTGTACTAAGTTTAACGGCCTTACTGTTTTGCCTTTGCTCACAGATGAAATGATTGCTCAATACATACCACTGTTAGCGGTACAATGCTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTAATACCATTTGCTATGCAAATGAAACATAAATTTAATGGTATTGAGTACACAGATGTTCTCTATGAGAACCAAAAATTGAGTGCCAACCAATTTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCCCCAAACACGCTTGTTAAACAACTTAGCTCCAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTGAAACATAACGGCCATGAAAACT ++ +%.0:;:776,+:2/*745597@.8@@866*<=68:9)$*$-%$%($$3447:>>>;)>9+-$,&%'&&''&%&%'$%989,0&)%&#$)(*$%&%)031/')*,&%##&&,(@;>>?C18@CB;4=@D==QH79-+.*,9=A;@=>D=A>@C>66BI7HHB11/0)$+$$$)*34,0(.-&($*-8:5*.01A7:@II?AB497<=()A4200-*)0.(6/67//+-16;DD<%$2;?BBBC=+3%%$$$$%'')+(./,(*(&)*)%):5::/-)--,B?==@@5;07C<M;>BA@800-$$'2,++56693426A>@A;B6A86;>=C5;AFF>@@?C?AFC?95,(,,2;@>:>BBBEC>A=F<9+333<=9D668;9<:99<968,0;C11'>445=&%78;89.-***01+-550159=>>AB6A22001=<><)@011AA>@=56)..12'(.2;1210<;9:;)'$%&'$$#%%'$%'#&&'%'('''%$$ +@SRR11410539.1646670 1646670/1 +TATTTTCGTTCAGTTACGTGTATTGCTAAGGTTAAGCAGACGACTACAAGCAGGCTCGACAGCACCTGTGGTGATTCAACTGAATACAGTAATCTTTGTTTTTAATATGGCAGTTTTTGTACACAATAAACCGTGCTAACTGGAATAACTGTTGAACAAGACAAAAACACCCAAAGTTTTTGCACAAAGTCAAACAAATTTTCACAAAACACCACCAATTAAAGATTTTGAATTGGTTTAATTTTACCTGCAAATATTACCAGATCCATCAAAACCAAACAAGGATATTTATTGAAGATCTATAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTTACTTTACAAAAGTTTAACGACGCCCCTTTGTTTTGCCACCTTTGCTCACAGATGAAATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACACTCTCCATCTTT ++ +(+,.9;78GD2+6-/A74::895757:,-;@FA8:)8679>=;;388=:-1/02037:13.3=::890741*,+&)3&''')&)(&+$'$&**,((97.+$$$.2999-.)$)*0444%)$'$$##&+-.,-03''3$&*.040'&'(09:-/46?;<>=A:FGIC860-85//%-'+652/3**559<;=;<82337<97.(&&562/.,>@::8F;@?@@/6ABID3.)))-.1>><=>9<&&%%%'$)*--4672(10;3<33A@>?FHIF@>>>%:56,*,)547@C>@@BEB@9<0-(*++-57,67<=?@A>=6F>CGAECGD?81;9:4222033,)254:=-(((+'(95*)&&)//?2225,*-568:74547+$%###$$+/775.1EF@CC78,+))))$$'6925CA=87C><=>D3<@A?>A::771/18965./*(359;?;<B7=7:<B63/7/4.48*-,..'(&$&128&,+($#$$ 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+$#%''455<?B0708E6,79=?BD?CB89/ALHEI=4*+/3203.)*5971*12>;:259=7666658053356803DC'':B:;8;98B9<:B4314)'8=97,7777-///12&)5?C@CGDHKHICD00///97@@(1'((?BBA;:@=035592;+,/;=A?D?9/.(%#&#&&-0%89=55:+++:;.)-))$%&(45663@C<;-1;:@@>:87C@ADB<@?7<=<)+&%))'#%+(2@A1%:+JMG<://A<<84;<9;:65?..5GEKG;=;<DA@BCD=<%%?-'35-+33DFD:8D;920+5+'%5:?D@<DF8E<3)410,*:>A5',99<??=?D?>5,5>>0''-4:<99GKKCE>>)*,017*%%7;=A@==;7<<8//-47>@>*?6:9<78?A=?C>67.,,,6;<?BDEBII9>B55BEF9@;8==;=B?A=5/683'=:1(64.06)))'(%')&&)%&&'.7-0199B03.//1,,1%%%-.64)8;<><78,,$ +@SRR11410539.868783 868783/1 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+CGGTGTGCTAGTTTCGATTACGTATTGCTAAGTTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACCTGGTTTGTTGCTCACAATTTTGACTTCCTTTTAGTTTTTAGTCCAGTACTCAATGGTCTTTGTTCTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTCTTGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAACCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTGTGTGCATCGGCTGAGTCATTATAAATCCACATTATGACAGCAAAGACTGTGTATGGTGGTGCTAGGAGGTGTGGTTGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTAATAAA ++ 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+CAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAGTGGAATCGACAGCACCTCATCAGGAATGCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTATCTACTGATAGTAACAAAATTGCCGATAAGTATGTCCGCAATTTAAACACCAGACTTTATGAGAGTGTCTCTATAGAAATAGAGATGTTGACACGAGCTTTGTGAATGAGTTTACGCATATTTTGCGTAAGCATTTCTCAATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAACAATGTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAAGGACCTCATGAATTTGCTCTCAACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTCTTTATGTATAA ++ 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+TAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAACACCTAAAGACCATTGAGTACTCTGGACTAAAACTAAAAGTGAAGTCAAAATTGTGAGTAACAACCAGTGGTGTGTACCCTTGATTCTTTTCACTGCACTTTGGAAAGTAACACCTGAGCATTGTCTAACAACATCAAAGGTGTAAATTCATCTTCTAATAAAGCACTACCCAATATGGTACGTCCATTCATACCATTTTGCAGTAATTCTTTTAATGAAGCACATATCTAAAACGGCAATTCCAGTTTGAGCAGAAAGAGGTCCTAGTATGTCAACATGGTCTTGTGTTAGAGGTTCATAATTGTACTTCATAGCCACAAGGTTAAAGTCATTAGAGTTGTGGTAAATCGATTGAGAAACCACCTGTCTCCATTTATAACAGCGGCGTACAACCAAGCTAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ 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+#%'(*&&-..,&*/3(-:14+0%($%+,*)-$$+=<:@C;8*..*87@@<7??5?584;;>:;5224/-'&'(,&9@=))*0.10131)A?800:?).C@8<:92/=340++'&'(*&3:98=@;A<:?5-1''(&,.**&&&(/(+3:=;:.2,2*(/07?A;22606<=2FA??0,-22+/=4@??8;=65&==;>B?BEEH;886.1.+<3)%#+-(&'$&)3*).+%)*#$$)),-'%'/+))(($$&&%$##$%#%'"#$%'')/).*(44:C16))8925-9--*9<24>9C?.,*%$(,.('0359?<>@9;-(+#=?<==;,,2-&%$((0'+'*$$$$%$%('$#%#'#'##'$((++45;77?D=GI=BBCHE89<5*+*+-&&$&$$(*+,(<>;%%.'&,&&0&'&*-(;>D/5-'*'%&&%%'#$2%$))1245%.11/3,&&&'*$$#&%3:??E*-%&##%)$%&+8%%**)/2+.$%$$')*)'(($$+)-, +@SRR11410539.628809 628809/1 +CGATGTGCTTCGTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCGGTAATACAAGGAGCTGGTGGCCATAGTTACAGCGCCGATCTAAAGTCATTTGGCTTAGGCGACAAATGGCACTGATCCTTATGAAGATTTTCAAAGAAAAACTGGAACACTAAACATAGCAGTGGTGTTACCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAAGACCTTCTAGCACGTGCTGGTAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGGGTGTATACTGCTGCCCGTGAACATGACATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +)$$%'0.9<A-BFF@70@?@7A?C<;=@@BID&>GE@C69)))'..0,))696;#'&79;DD:83;=<=DD:;>=3(+%*+'1+7>AABDCDA?>:6530&-&-:<DCBC:C=CE,$67001/$%'('/08<,+&%''**.4744@@$$.$'::94<96BDN:>;;'(7:-*;79<@75-680CDC>:52<-&8?=?=D71)2499?<>;>;9CC:????<<<<:;A9?AA5-:><78C<AFA22CF==79005*))&%#'*8658:;B54444;01(7::D9=?F8948CBBCGAIKC,<G?ABCE<3BAB:AHD989;:/01.47@<<BCE?DEK@&&A?=EH>6>FCHG?GGIHEIKJDB>?<=23>>=@BA)&78780&--/+#$&%%%&%125:3ABEH?5678<@E9ICDIRHD;K8@568C4*-HIHKH*==>=A.@<<F7@C?EBA<BCAB>94=AGG?B9EB@75@48=99?8?BBAGH;;=52+.348<334(- +@SRR11410539.392938 392938/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCTTTGCCTAACAAATATGGACTGAGACTGACCTTACTAAAGGACCTCATGAACCCCGCTCTCCAACATATAATGCCTAGTTAAACAGGGTGATGATTATGTACATTCCTTACCCAGATCCATCAAGAATCCTAGGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGAAATTTTTACTTTATGATTGAACGGTTCGTGTCTTTAGCTATAGTGCTTACCCACTTCCCACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTGTGCCTGGCTACATAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ ++./2>/&&AD@Q17,<0/)A>CBCH<=>::1DHFBE+==<E>CA>;2<:>>;()1B>>A:0,.--.,$%&.''(-/*%%-6:>33478;-*6,8=7::>>BC-+D?7:9=3.-(&$$$$.16.3$5()'(%$&**.+%#(->7=DF?==>66@65:9BF?;2*(#%%%(/-&(-05766A88A=7=++25@**/1''('3;C@=DACB>>D738?8<???BD8>DA?>>A;AAB>882234743/'#$%-*,:9=<:67<'+==3-E;679>:111-810)0*,-.<AC@7//+)))2376810A))*EAF=4=+&+%@?>@<CDAIA?B@@C=11+#�'%%)-%#$%1%..-1(,5:;8105<8DBC7693<EDA+<:56G?8?;<78:??9>B==953..$$&.6/;;<=><;:58790656-AC?=?268FLAGIB?BDB0@DG;JHE>?64CDAB>:BCDKE+=;A@E??B@:+88=87CDA886956438@AAGC9632%% +@SRR11410539.1236414 1236414/1 +CGTACTTCGTTCAGTTACATGTAGGTTAAACAGGCGACTACAAACGGAATCGACAGCACTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAAAATTGTCACCTGAAATTGAGAGTGTTCAGGCATTCTTTAAGCTTGTAAATAAATTTTGGCTTTGTGTTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTAATTTGGAAACATTTGTCACTCAAAGGTTGTACGAGAAAAGTGTGTTAAATCAGAGAAGAAACTAGCTACTCATGCCTCCAAAAGCCCCAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCCACAGAAGTGTTAACAGAAGTTGTCTTGAAAACTGGTACGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTGCAGGTGCTGTCATTCCGTTTGTAGTCGTCTGTTTAACAACAACT ++ +'$&'02568A470@:;55%#%(((?>:9;=3+-&.311-*$-/&,'*%1:9<;8:7894(:0*-4;;EGAD=;>?E@BB>78/(+,,2:26+,,8=@A?@.@33>=B3?523507:8<C<>72@+19=@98@A275:@30+)(('-*/430#$$%&<?@.2/-$'248>BA956%5677;68@=5:<GHIC4978:8*0-/1&&4>;BA>=D;;89B9<?-306;1:?;DGBFICBEE=9:82(+(,;(-'''(//2:1+,*7099<&(2$)(,**$$,5*74=@AEB<845-14<6-095,,,%$$%%++-,7<@=399?&(BGE07ICG;IC3'9?ECEF99JDAKD@@0@>,<=:@5<:**=BC=;99@7<;9@D?@++,,*(*127(-,+,5646/()$%'%'337:?<::;CC>>=?98??4474-520/,::<C5?>>B56*1(#$(.-3890598//,,.-1:<=B74569::>?:;974/.*&&&$%($ 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+GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTTAGCGGCCCCTTCTGTAAAACACGCACAGAATTTTGAGCAGTTTCAAGAGTGCAGGAGAAAATTGATCGACACAACACGAGCAGCCTCTGATGCAAATGCATAAAGAGGACTCAGTATTGATTTCTGTTCACCAATATTCAGGCACCTTTTTTAGCTTTTTCCTTTGTAACTTTTATAAAATTTCACAGGATTCAACAATTTGTTGAATGCTTTATAATCAAACCTTTCACAGTTTCCACAAAAGCACTTGTGGAAGCGAAAAGATGCTGGAAAAAATGGCGATCTCTTCATTAAGTTTAAAGTCACCAACAATATTGATGTTGACTTTCTCTTTTGGAGTATTTCAAGAAGGGTTGTCATTAAAGACATTCGGAACCTTCTCCAACAACACCAGGTGCTCATCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +(+-396;=>><H?5/88<6?<?C=?9:;))2?HDOOI?66DB@HDDA@8:-*%'-16<==;<?>9>@@BC>?::820%%.2&,%57<?=>=DGDBB@2<>CCAD?A-54CDLC-.4*:AC0,E;0:B:C;4:D?81)',7;8;::8))1,(,,():+117068:@CBE@?>@(3(9ABA=B:<?;<:9=CD>?8=EFGE??C??EB+=B>?FB?54;HB33-/*-*&+856<?@44&&$&'''#.351.-1%4*<:<<>=<E;<;CB=??0$%-'8<=556?@:<:1?<?2=@JKD744*2EED?C:9BCB*,,,,6>?@=>33+3%%C;)04/)$&&',4966(423=;A?CC@H@3.-..+(;DGFHIA>C8BAA?>HMIJC>:)A)CDFE@IKJEF;EA@4*,(-828<:9)*.&&-/<DD=;B?@>)*%'./+69>)/)8?AB/8:);..223C>A943/+$$.()6<>CCC;>>HDH8;FC:=98@?ABCKABCDHKKA=>@EC=CD5.$) +@SRR11410539.1425784 1425784/1 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+CGATGTACTTCGTTCAGTTACACGTATTGCTAGGTGCAAACAGACGACTACAAACGGAATCGACAGCACCTCCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAGTGCAACAGGATATTCACTCATTATTCTGTAATTTGACAGCAGAATTGGCCCTTAAAGCTGTTACAATAAGAGGCCATGCTAAATTAGGTGAATTGTCCATACTAATTTCACTAAGTTGAACAATTTTACTATCTGCATCTACAACCTGTTGGATTTCCCACAATGCTGATGCATAAGTAAATGTTGTACCATCACACGTATTTTTATATGTGTTATAGTCTGGTATGACAACCATTAGTTTGGCTGCTGTTGTAAGAGGTATTATGTTCAAGGGAACACAACCATCTCTTGCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACAATACGTA ++ +%%%&).-45=.AN;@8@?=-(+=?B@@<-/(%($)&0477</068@DCBF@IJ5?,.2>8C<DBHDB4056&;27,429<76=DBEGAGECC8385633=:<>?&%(+=@BC@<A84A9=FBB=?.5(+48E6BD:;D@3>=CG63CDB@<;2/>6<BDC;1,,-1AB>34*(.3....1,&)-179;7845131+.+->B:5-+02.*855.-6:113:E>1=C>FGEAEF;<;C;>A;5C@BAC<?;;4**=@BDDBB;:;=7;D=DABEBGBDBC<?=CA>>9;DD69OB?=@-<=@=BA=BCGC;;C@IA@?676837565;:7:65;D<=?>?793529;?B<=CD=63=>GCF=4DCCIHIHKJD@EF?B:ECFIHD?8A9<==<FKH?99B=BE>5A6459<@C=CEDJIC?))0235BHFFD?DC<=01/>?;@BK>99CA@>D8=IJC>BA-8DEC>B=CCJF:9:?MKOACE?8;89>7;;942+(--,,1,)) +@SRR11410539.59797 59797/1 +CATTAGCCTTCGTTAAGTTACGTATTGTAAGGTTAAACGAACTGACTACAAACGGAATCGACAGCACCTGGCACATGGCTTTTGAGTTGACATCTATGAAGTATTTTTGTATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCACTGCTTCAGACACTTATGCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTATGGTGTGATCGTCTGTGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTGAAGGTTCAACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACATAAC ++ ++%$&'&&&'*$'5)%%*121500.**&3/0-ALEDH/7++3++<762:6774/$&$09<@E>8B@B<<B=>@BEBI@C==50//-<=4-*3<:>@>50.-(,-,-,,5-+$&5;;;=A==<@=>?:?@ECEF@:<@@9:<;8348,/,;@<>0330//12725.():7886-,34/,-16:;>?<==7;?;7A9:=91+-1*0*9<@BAA?28;:;5('148;A:HH:CFGEDGHDCE@@934=446-0<;CB7$$&'))78DBF<=GHC:?>><;4320*@2=C?DE2,ACD?68;;2?CC6;@?BDD7((%%000<9960(&'02$$9==>6521=624.)4>=@23@<E445IB>JLGDJH+-D=AGHEB>>::;>A?@98=>??=B78:F=:+++-9<E11A?@H?AGF:7<=>=?>=<67ADD?:43<&-(6;--3095>46;<;;CCEB=?:>=E5AEB;>9491&-,+01%*%$,--/0(**+' +@SRR11410539.1172049 1172049/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTCAATAGCCGCCACTAGAGGAGCTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAGCGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTAACATTTGTCAGAAAGCTGTCACGGCCAATGTTAATGCACTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTTAACACTTAACGTACGTAA ++ +*--)+*9:;76H15-4A@>:8:=CF?A?$&5BMGDH=6061187:;9;<=:5,0-7;54317:=D>?J>;/-*,-;<=@?A>;A7?:C22.,-/32>>=>@=?BB@CC<@@@@CAB62147D;A==40+.3/+*>88EDABBA<;?DDE;3/.0:789'68230=)@B<B:>?@?:44+09F?-3@=FB-);.>FC;<88:=998IFF<?=IH??A=FAA:??;:>B;=AE?@>=G@==@B8:>9CC<<JE>AJKF<>;=(=%65@1;;-+57>??:6?:2=:>;?<7%?C693BEA9A@E@C=9;BD<?<?,A235ABC3$):>?MEF=A>?>:8+@87629>FFAA66::C;>IIGK>B;25??DD<;8;:>7:=<989;:9576.6117;77>AI<;??;>5>>EB=>E76=EBA?HB:29+,,'?@<@@C@E>><<06BEBCFFB@13>>B>7:;;52;964=>$&3=8:302+20569:9;;4,+/'#$$$$'#&#$$$#$ +@SRR11410539.2265078 2265078/1 +GTTGTGCTTCGTTCCGGTTACGTACTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGCTAACTACACTTAACGGTCTTTGGTGCCGATGACGCTGAGTTTACAATCTATTGGTGTACTTGATCCCTCTGAAGACATGCTTAACCTAATTATGAAGATTTATATTCGTAGAGTCTAATCGCATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGGCGC ++ +-().:3:===9A?$)%*770/*)%00,-*(0'*%:<<D=BCC?8:<>/=:<?=<1=?7659B;;DA@@B<BGIACAAE==A49&--,;?B:9B?EFC;9;5==4.22/0.+*&/32634&256AEE>?;=??2$%#$$$')+,)5%$('$',3,$)''%($""$$%&#&$%&'*)))+():899=;,''&%#$&%&;<A9;94%,++((&-0+$$'++&%%'$%79<67893./9>@GCKA5401,,+59;/4;=?58E<>'(<83,;=<4;<AFBDF=A@ADAA===<<8:47*<.37779-.8(((%&0&343@<7>35702&&+;ACEI>>:669;3A?A7897<CAG=://87;>--//68<5?<A==HGG,'$'03420---4-<?@BHE?<>B0399;<:?@59>?::3,68BC;>-=?BA?88.3.39;:==69:ADL278:ABJ98866726<C?<=8,,*)(('&&&'(&-#($'%$$ 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+&(&&49=>>FB?7:=?/;>CC<?..9)*672,+(&''*>?=:=7<</4$'&-3.(&(373:9789<:<49)D=3BD;50,+'(.10299:?A:67309:6'455/)*+/7:700-/53*-+()-&&',324.&&+324731130*-7:>@@>@>?:BA%$$$<:@D5/EKCF<==<<9>78865@@<=>;*+))&(*'8<>=-./366106;05=C9>74+>90))('-29>83:994:.(()&&+..%+'$074<(0--*57333-$''()686',@?35,,-@>=;432'+./++&&+,,3768-::;>?0*7**+0,2$%::21A656+*-56;<HE<&'-@GD?6'$/611,55;:;C<67928023498>?=>@:87521,,1()2=8+%1&&(.+,30,&-74%%(;?<>?9:98601/23??A???>4-;464-,75..9./(1>==E82/.')'+-02A@B?@;=;;;52()#$'&$$$# +@SRR11410539.1152939 1152939/1 +CAGTATGCTTCGTTCAGTTACACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAATTACCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTGCTGTAAGATGCTGCTAAAAACACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTATTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACAACTTGTGCTGACAATGACCCTGTGGGTTTTACATAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTGTAATGCGTAACT ++ +&$&)*,,;=.00?;;1:DB7$6=<?;=A+9;BA-ALKILA<=<;GCF@99DBE;@589G<=@B531/,237@?BA9933BBA@>F=;AAC:>A;@@CD>>HCA@%%721/1$%&9<DDDBD:.//::5+1*+:;<GF7>3(=+**0=464..&'1,1-.50//,.21&%55>?()<BA0,:/+<;4.+5*,26@<:23:<>=9BA?C@CDG=F<FE;<=:5&DE8B?@A&@%=2=&4573='+7365),0=33@CGE@9940@?*$%'8B797@4@AEF>@?<A?:?34EAH:;?CDD53A:<??<:77-,'16=>CFC64:::564<<**-)-$%.(97CA''?%%%78:845+)131BDEA.<>?:BBEI>+)4E@C?>@2167@AB82$/./9:;;=11200.$$%+'@A<>2><8=EGG/%1$'%'-/824430;7<6=773;?49B.:HA>::;@8<.?C705&<>@@A;8;?AJF<>8@?275:9>78=9,:;+983400*+**'&)*,-/-) +@SRR11410539.366867 366867/1 +CAGTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAACAAGATCGACAGCACCTCAGCCCCTATTAAACAGCCTGCGTGTTTGAAAAACATTAGAACCTGTAGAATAAACACGCCAAGTAGGGAGTAAGTTGATCTGCATGAATAGCAACAGGACTTCTGTGCAGTTAACACCCTGATAAAGAACAGCAACCTGGTTAAGAAGTATTTGTTCCTGGTGTTATAACACTGACACCACCAAAAGAACATGGTGTAATGTCAAGAATCTCAAGTGTCTGTGGATCACGGACAGCATCATTAGTGTCAGCAATGTCTCTGCCAAATTGTTGGAAAGGCAGAAACTTTTGTTAGACTCGAAATAAGAACACCTGTGCCTGTTAAACCATTGAAGTTAGAAATTGACACATTTGTTTTTAACCAAATTAGTAGACTTTTAGGTCCACAAACAGTTGCTGGAGGTGCTGTCGATTCCGTTTA ++ +*$#&(-(--/)(-)-&0<>B@<<<CD<@?./2175)-(167?=A<<=79&'2$&&'%31-;88;;;;9,)(%*-,+&-0=?71+9=>><(1I<?BA?<'9>8>0/0:4:B744963=/ECLNJAGEJLI50-9=<++*+,-247;;8;<6AE>?@DK>J;=()')(4704.'7:@2,)4541389>,)6=@<EC4/-.+2(0458;B25;A.0%&&,33<@GDC@%&3)+8/<;:?663A;893>;939:CED?-);DF@D6:89:;<@5/79;4=?:=;?46;D70/&&*3646:29-0=/5-6-2*$#$%16657=04;<:99;?;....02337'&*%)14(045)(+4,<CDID4;5&&<5/(%('%*&)-0;;:=<:01;CDH@??;;:;<=DDC@A979&&(4=@CF>@*B;@AC32;B@@?B<FABFC2*(:5<6?GGG.4)4;=B?EIKF1)@@@66B8<9??D?=C73=A>?-*,$$5)# +@SRR11410539.1660182 1660182/1 +GTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTTTTAGAACAACTTCAGAATCACCATTAGCAACAGCCTGCTCATAGCTTCTTGAGCAGTAGCAAAGCTGCATATGATGGAAGGGAACTAAACTCTGAGGCTATAGCTTGTAAGGTTGCCCTGTTGTCCAGCATTTCTTCACAAAGCTTGTTTATGTCTACAGCACCCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTTCAAGGCTTCAGTAGTATCTTTAGCTAAAGAATGTCATTGTGTAACTGGACACATTGAGCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAGTAAGACTACTGATGTGCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +$&%-&,,18;C,:5:DE?A=GHFG?ABC9.A?9:;18--=->??20-/0')0337::@EDJEC@::CAFEAB?=0;618HKCA9>45448@=<=CB;;333CDDEC=;<0/($4:;;2.*+>??@JC@.@&=56,,+6+8D5ED=ADA@BHIFCDGHBGAC?FCD5+%$$$"%.115;:56),5<3666.'021378489=98:*4;=BCC:=;>=??>D>@EB>>=?;9,@A>;//9:==;EGMJE<:756<F>CBFEB?KGCIAGE:;@FG:?=>A?>:=,'77:<>EC?AAC;;+/7511:@BHE=;8?6238,.,9(39;<;@BIC1856)0''9>;8@A6-889DFGFB?:CD*&+;36=A?@@=B9>;5=BADCB:0-+/=7?9.$%*3*-;<>?C//B;A>;CC88>C27+:EG@BC8AGGH:7797+5(CACC=5@DGEGBF6C<A./77@BAGB<A767?:<7<9:04>9;C>>@=C::>?@=AD@;67AACFCDA31) +@SRR11410539.1874045 1874045/1 +CAGTAATGCTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTAAACGGAATCGACAGCACCTTTTGACTCCTTTGAGCACTGGCTCAGAGTCGTCTTCATCAAATTTGCAGCAGGATCCACAAGAACAACAGCCCTTGAGACAACTACAGCAACTGGTCATACAGCAAAGCATAATTGTCACCATTACTATGGCAATCAAGCCAGCTATAAAACCTAGCCAAATGTACCATGGCCATTTTATATACTGCTCATACTTTCCAAGTTCTTGGAGTCAGATGAGAGATTCATTTAAATTCTTGGCAACCTCATTGAGGCGGTCAATTTCTTTTTGAATGTTTACAACTGAAGCATTAATGCCAGAGATGTCACCTAAATCAACATCTGGTGATGTATGATTCTTAAAATATTATCTAACTCCTCCTTGAATGAGTCTAATTCAGGTTGCAAAGGAAGGTGCTGTCGTTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&%#&$$$#'(.(;G=81>FD;==EFDDBA;GG)-DCCFJ8;254852-)*+)*-0/3645266:B>3BDAFADDAC8;;;:87DHCEIBEBGAD<;;;>@<=HBBC>C:=><<9*0++(+58?)):9:@C5GE>*+31267++-/.6:7679830,CB14?D9=:=0.-,*++;>8;>HB<=;@@>EEEA<<??<>=>;=>;72<89-A<87B?C;>A?5<<712/4;:9002,;<9?7;@<9976665.-,),3=A6=;?9;=A/5,-:7:BF)%&*$'',,9>=A.99BCEA?@?A>>:;@<=;*1578579E1182180/;:0==@9:C<CDGD=:<@579:;C823<:96*0:CECBDADC>@@?AD>=?CFC<;:=G=A23=49?569?D?>A==ADDKFC>?DC@.&&-/54=7>?AH,408;<BDEI<:9A?@@@A@6;59CAF>;=<&74-,%);-.2+'&$'.:=;B>A?BGB=??;A;?CCI442625@.:@@=>:7.'()) +@SRR11410539.2289681 2289681/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTGGCACATGCTACGCAACTTTAGATACATTTCTTTATTTAACAAAAGGTGCACAGCGCAGCTTCTTCAAAAGTACTAAAGAAACACCATTAAAGACTACACGTCTCTTTGAGTAGTACTAAAGAACCAATAGAAATGCTTTGTGGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGTACTAAAGGAATGTGAGAACATAACCATCCACTGAATATGTGCTAAAAAGAAACATCATTAGTAAAATAAATGTATCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATGAGTAAACTGGTGTTAAACAGAATACAGTGAATGACATAAGGAATAGTATTAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACGTAACT ++ +%566;7<A?=?N(<4<CBCA;7A:=9?>568APKGIA;3458;9:>65+.(($)-777=?55277=>;%.04<3((+6?<-/$%89;EC@CDEA677(((4ABHGGCB>BB*&+9D>>66695)::;4483?28GH614;'&,((&($-1/<6;=EE23.9A88@.?;;:;DA@A,(#1)0%(%0656;*A6<;AA::8-2D33599A1>7.%9E>?GAFHI@@?B=902':9<7@<EGD--:7/:?+-.4><=AC4+;$$$%///%+-'33=?A>B:;BE@@DEICF;?E?@9EOH.$'98&<E?@4435-601*.-,,,('$&5>9:<FI8<@<BEIGB?B=G<>G=@AC@;<::@D?44:?B900@=FID?@BE<F>:-/3-))*&-3352BGGICB@?;<>?>@EF4</=//4CE?::6<:<>*/:=+,>AGC8?;:;EAEDA;385=88%-.<6:<40?<9?A;=AEAB051/%64878>8512978;:BDFD>?BED<.%- +@SRR11410539.2225052 2225052/1 +AACATTCGTTCAGTTACGTATAGGGTTAGCGCGACGACTAAACCAATCGGCAACTTTTCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTGGAGAACTCCGTGGAGGAGGTCTTATCAGAGCACGTCAACATCTTAAAGATAACTTTTATTGGCTTAGTAGAGGATTGAAAGGTTTTGCCTCTTGAGGCAACCCCTAGTGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGAGCTGGTAGCAGAACTCAGAAGGCATTAGTACAGTCGTAGTGGTGAACACTTGGTGTCCTTGTCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAGGTTCTTCTTCTGGCAGAACGGTAATAAAGGAGCTGGTGGCCATAATTGCGGCGCCGATCTAAGTCATTTGACTTAGGCGACAGGCAACGATCACTTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAGCCTTAACCGTACATGCTT ++ +##%$%+-6661-:5890-&$%,%''&+%%#$$'$'*$(+'(%%&$.07'&'''#$$$$+,.15-00/+.03?A7@3>=@:2=01;>8A;5,2,)(($%('(+,,(*'2+,.+)%)+++,/34-,%%'.'2/79'(,,+-$$*+%(.-$%####%)),,0''15-)*%%%(%%'%%'$%&*+++$##$$"#$$&&5'(+**)('#%&)*&-3+%(*''79<83&)9502667-29::@<>;=A6<4:<@<<:-/9886.041%1499-0-(1+(,&9?58&''&'',)(%&&(%&$&))**+/002<>55;8889==995;=5<3789;88;7.36EE303=<<ID=?C=>%%=;DD3041@GA=@=853-$'))9,?CB679398;;+'$$))+,.0%%0.$#$&$..4*0:/.,)+-8-02.61)),7=1(33==<@?:0$%')%%.'&&7#"%&%*.)3=,:@BAA@2BBJCH75==<?=<B?A;1.*%&#$#$((('$''0+++*** +@SRR11410539.2393508 2393508/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACGAACTGACTACAAACGGAATCGACAGCACCTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAGATCGCTGAGATTCCTAAAGAGGAGAGGGTTAAGCCATTTATAACTGAAGAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAGAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAAATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAGAAAAGATGCTCCATATATAGTAGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATATGCT ++ +$$45:7328(7:D4557FFDA@EI?B-;.A(BBDFI9C=<H?AKGBEE<881A683;2-:<;<>CHABLG:@GFA@AE<??B@@AFD9GCED=>HF5@=4BFCEA9:@>25888;AC@BFH=B@>BBCBBHIOJI=>BD?;899''/7++7:/.:ED@B@229>EE.+2,3/5<>BCCFD;=@JI,49B,3'&$&1(1;=<;:?ACH;6=@:786&&%)>BFE>EI7===ED66;'547('9H@7*-5EC?A<DF<5$6DB7-8DD@=ACC>FGE/E'G576,,949<;=;<@>DA2C>>:AC=/*7$%$<><335/$$$$8JH>?GH7E<8:;?A<<<GDIKGDDEFGI>FFBD=?CA-+--3)('-14-514>?F@GIDEFGDCC;>==ADB>C=>?556;.45::,=J9(/@:326=A>DB>)./2($024;CEKFMP<F=D,,=@?5511?AJDCD?EBBA>%2317/5FDCEA<@DDKGAB6ECJDA@@9@87A=:??B88=?846*3,-*(%%#$ +@SRR11410539.714447 714447/1 +CATTGCTGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTAAGGTGTCTGCAATTCATAGCTCTTTTCAAAACGTTCCGTGTGCCAAGCAATTTCATGCTCATGTTCGGCAGCAGTATACACCCCTCTTAGTGTCAATAAAGTCCAGTTGTTCGGACAAAGTGCATGAAGCTTTACCAGCACGTGCTAGAAGGTCTTTAATGCACTCAGAGGGTAGCCATCAGGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCCTCCGTTAAGCTCGCATGAGTTCCGGGTAACACCACTGCTATGTTTAGTGTTCAGTTTTTCTTGAAAATCTTCATAAGGATCTGGTGCCAAGCTCCGTCGCCTAAGTCAAATGAGCGCCGTAACTATCGGCCTGGCTCCTTTATTACCGAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAG ++ ++$$%%&('3/3&()+&//20?>36;45,@HIIK:1,/-,0/.56767+*'%42/110()./1%9;<38B70,35?::7.0'%1(:??GFH>@$%::61@A=@;E;=%26;?9A<96;D?4,)$27A536')%'-*+.'972,+*,;9;614-'#&.+++5;>6712./?7<FF4?-A8>=>;;52.02&((')2@BC:-474=??80'),0+,8/3C;<=;06:8:@.8=*7&9=36>8CBAC?82;>9:..*9''':-2<>@;8C>C9?9;70)**A8223455==@;>9@<89@><?%7/'()7?)6.2481/0065757:===5<@DB823;;E(3+<,3?=?9:?=8><A<>:;4%'))-95(;*(-9:==571-4$+&.)47982358@;;6,+'%*,&,569.&+,--(-./)$)68(1(+<935-=7;.$%$999;>>9@:<AB48:FEG=:A=<=:8;:788556694/&)5:7004%%## +@SRR11410539.2067893 2067893/1 +TGGTGCGCTGGACAGTTGCGTATTGCTAAGGTTAAACAGACGACTACAAACAGGAGATCGACGGCACCTGGCAGCATCTGCAGCAAAGCGCAGAAAGATGTATACGGTTGAATTGTGGCTGGAAAAAGCTGTTGCATTACCAGCTTGTGGGCATTGCTGTGGCAGCCAAACTACCAAGTACCATATACCTCTATTTAGGTTGTTTAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCTACAAGGTGGTTCCAGTTCTGTATGGGTGGTACCAGTTCCATCACTCTTAGGGAATCTAGCCCATTTCAAATCCTGTAAATCGGATAACAGTGCAAGTACAAGCCTACCTCCCTTTGTTATTGTTGTAGTAAGCTAACGCGGTAATATCCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGGCAACTAACAACCATGGC ++ +#$%)'%%$&(+%$$&)+#$$%,-1388())7++%+%922;62/,826464)&,()%68<@85)13/446'++*,6.)81)**'0..+%&+./.40%(>:541189+1@<94504#)%&%'$&$$%%%$$&((+()(35-/+$*'-337*,-6*+0+366300%&$#%&(*00:?>=>8C:1/'$28:79:=AA???=>9<=2/0069:;=?A><>467(,6>;>@2+,:>>?>788<>9?G8;@?812+(&&+,,306/0;DD:;;>A<88''/02@@5:9?C20+'*))#%#&%+2-1/*5:4./-79AC@D9.3)1.592>:?ADDB=<@30.150142.,585)4<@B>67625GBC?@>EA>==+CB81<9?<?54556%'(),=CDC@<?=654==90.&1#%%%(*/''815>?999$(,+4:D@<?>A?@?<:-.869@?B<=<848:@?B>@<;()'8?=<;*%,013?665:52*')48>>;A;>867%(.++*,**4+*)/'&&%# +@SRR11410539.699316 699316/1 +GTTGTAGCGTTCAGTTGCAATATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCTTTAAGATATTGACATTACCTCTGTCAGACCCTATCCACGGAGTCTCAAAGCCACGTACAACGTCGAACACATAAACGAGCAAACTGGGTTCGGACATGTGTTTTGCTCTCGTTGAAGCGGACAGGCTCTCATCCTTCTTTCAGGTCACCCGGACAAAACCCTAGATATGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCAGCCTGCAGAAGATAGACGAGTTACTCGTGTCCTATCATCAACGACAGTAATTAGTTATTAATTATACTGCGTGAGTGCACTAACATGCAGCCAGTGACAACCACAGTTTTAAGAAGATCGTTTAGAGAACAGATCTACAAGAGATCGAAAGTTGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTAAC ++ +$&)$(+*4987)'..3$2#%%(%&$$%$&4;@FF?==>=B=501,7474=03(/'10016989>=E@=93571//7/**;+,+/$$%%+).++#&$%+%+*)'$(&1+.&**:9;:>456((),,&'&4%),+)'%%%*$&%$#&*(%$&3$)(**#$$#&$#(43$&$%%(*###"%)(+687754&1$*)*%&')*)%+(.+(%%&&*.-&*58>3>IG>DACHG>@@B=:%%7,(*%%(&&-))7=6<@B@A?@>EG=A=@56@A<<9:>?7,'>CCFD<//<9992--?9665C@:?A35D867>,$%$%%&''))*)'$*''*01;91/$)-..;*%%$$,:9CA6E>@@:9.$)#1&&+.()(')65/0$%&&%'%($)(&$)%''*&--/7=700/---.**'*7&%*$&%7;2&:,-:7DDD67:=<?B006@>@>4<?BBCC59?FA=28:8<><=ADDCC=6667515%&'($$857()$ +@SRR11410539.1242026 1242026/1 +CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCGCCTTGCACATCGGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATCATGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTGCTTTCCATGCAGGTGCTGTAGACATAAACAAGCTTTGTGAAAGGAAATGCTGGACAACAGAACCTTACAAGCTATCGCCTCAGAGTTTAGTTCCCTTCCATCATATACAGCTTTACTGCCTATCAAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACATAACTTAAT ++ ++%%)&(&%&));@<?9@9;81,:;;@==?775<@?<AC<:<61-,,-))12.-1311%:34,+((%::<E@547>=?(.@?<:;@93-59(71=24ME580/3..?>2C*,;7>3859C:6D>8:8-0>;9/825>A29()&$$%%*,29<>925565568;=>A=<3422/131//'':539:342**428<DFC@@KOLFB==?GG9<FADE<>?F@B@AA6'&&'+%0,*)--33@ADIG>A@BB;9;=2268'78;C<<>;2'&&..-&$19:<H>CB;::''()(.>854487,)$%,-1/=4*-BD;:?>=692278:>:<2%+%%)%.&(('%&%$%$(%+,)*'$'''%%%;<::E@;=3,A,?<&<<EFA)->CDOC<9;5:**?:AB;>?JMC)&,14@<<,1-99:FFED>FBC;55?9NR@>?=@53ACEB><;889,('/55@@A6>.38?<;C><=:;;A57>GEJBAFB<>=;?AD<:-*.$'#$$&',-' +@SRR11410539.2288664 2288664/1 +TAGTAGCGTTCAGTTACGTATTGCTAAGGTTAAGTAGACGACTACAAGAATCGACAGCACCAGATGACATGGTTTGTAAGCCAATCATCTGCGCGTATGCCTTCAACAGGTGAACGTGTACGCCAAGCTTTCTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATGATACGCTTCAAGAAAGATGTTGGGTTACTGGGCGGAGATTCAACATTATTCGTGTTAATGCCTATATTAACGCCTTGACCAGGGCTTTAGCGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTGGTGGGGATTTGTTTATTATGACTTCACGGAAGAGGTTAAAACTCTTTGACAGTTGCATTGGGTGCTATTCGGGTGTGGTTTGGCGTGTGTAGTCTGTTTACGTCTGCCAACGCTCCCTTCTATTT ++ +#$&&$*+2?5C;?AB9;510//352''-BB<33,+.0/<>B5531**#%168@?.5(,+*%%()%&#&%(#&&&%'+(($('#%$$$%&%$$&&%$##$#$#%$$#$,339:;=;6>=9<B;:4*+&###&&26418<;4'7:5835),)').+015C<=<897:94*@:;?@A?@CAD?FD==;;<876BAC>><458?DC;@46=?;@C<;?D39>AB?A?@>?=>;;EEF=CBA@AD8<(&%%#$'$"$%%$%%(&&'$%$#&$&'%&$$'%('.$'$$%)-&$%&%*379<+$72129<@B@<E?995700*''''*>AB?;<E;ADEDA@>>6+,%3452<7<=DAA=A<@CMH=M=5-&,.*%&)%%&2$#$$''%')+%/0+%)*'%#$0:?=6C;C88JKCD,*7BA><<<9%'37721)($&'*&*,/0%'$/'%'$#&$$'%,$+(-'+.&(&$#%%$%$$%&$%,.-%&((-,++,''(%')).++2,+*14, +@SRR11410539.2011633 2011633/1 +GTGTGCTTCGTTCGGTTACGTATTGCTAAGGTTAAACGAACGACTACAAGCGGAATCGACAGCACCTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTACTATTCGCCCATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGATAATTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATAATTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTGTTAAATAAAAATGTATCTAAAGTTGCGTAGTGATGTGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCCTGTTTAACCTTAGCAATACGTGAGCTTT ++ +'/)1'..127=*8',/1+-*2-/1349222EDA58+1%%+)3211)*/2$(*+(.;B>8899972523(*+%$)+(41:7?@==215%7-$%%'+%'&&(-)1754)5&''';:5/=89<=87:;33'(<79;7?<18..6:@FF;6;,?;?@CJI?//.,-C;DDDFB;70,$3$$(-/038535=;;>569>8;>@@IE?45GB9=359=9=C=>;<6;9FC<;;89)7A=?E><?8H@A@B+/2?<;>DD:06@78=90$)$68:@C=>:;AC,,8>??B=:>?;C<<F@=>>97536>:>/;GGC279:7796:58:9:DK?HC>79;?=;@BC>:=<'/-6?=?;>=9?9<BA3870()(-<?@@+1,14/4/622364/)0(*)&,65?54C:G@A41/23887<=>@?9@A1'==B@B>B@>>01/35CDAFC@@AC098<0?-,=3-::8BDFJ@@B8EC@8655<:6++.A@;?@>?7740*))++/056('&&%%*' +@SRR11410539.2215734 2215734/1 +CAGTATTGCTTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAAGCGAGGAATCGACAGCACCTTAAGGATCAGTGCCAAGCTCGCCTAAGTCAAAAATGATAAAGATCGCGCCGTAACTATGGCCACCGAAACTTTATTACCGTTCTTACGAAGAAAGACCTTGCGGTCGCCACTGGTATTTCGCCACATGGTCAGGACGCAAGTGTCTCACCACTACGACCGTACTGAATGCCTTCGAGTTCTGCTACCGACTCGGCCATAACATGACCATGGTGCGGTTCGAGCATCCGAACGTTTGATGAACACATGGGGGCTGTTCAAGTTGAGCCAAAACGCCTTTTCCAACTTCTACTAAGCCACAAGTGCCATCTTTAAGATGTTGACGATGCCTCAGACCTCCTCCACGGAGTCTCGAAAGCCACGGCCGAGCACGTCGCGAACCTGTAAAACAGAGGATGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAGC ++ +,%)''%%%$&'(%1;<>8984-,.0--1)-5,,5EKC25'0,.--3255(+$%$'1**-0<=8;>B+9%1,6868../B;3=6@FAF@A?5<<DDDA;12)&*02/023.-(%$&(-/-*/5795890/36936:6594/,($)*,+-,..:<?LGFGFH;862-<2%(-#'#%*/()$$(,,565,-)+./.&%%$+-,1&((#%'1'2$&/00=&''((')-32/+(67148@FAEIHH44<=D8?@.>::>%%$0.)'$%*('$')3(:89?@>CA@@,&),>;:%-9;<@>@;C00@@9;?<<@CB:;>@E7A;<;%+<;=<2+5/>%&7%'2%%&5=>;@&5556520+4+*)+.:4/<=@A/A<;==?8GCC?C?AEDC<;1;479<FC@99@:851'$$0//;49=9C54)+*0,;21)09>$3300(*)*78::(=2/>:;<<@@C>9-69:?;<;(1:%-&'++*@<?<D5:18=GB@9>;=<ACFEBCFDE=@>7@,7CC?@D?;02&' +@SRR11410539.455079 455079/1 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+/$$)$''%$72<?GG?<?ADD50-*+.4;412.>EEHLI>@=G<@D;;=>=>/:25265>@H7G5CE<??<GCSB@@*?::.++0/5>8/98?<@<=-5==>>AA702;;</:332<&=?6:>BDB=9:?991DB?=B>@A>6%:64>9;=<=D?>@20;:53&&,.$%1A-EIKFLBDGJGAFEE<;HE?BAILKAADJB>E66B=<CCA67)(+,008F@C>@>?/,/>>:,09A;87(&*9:8B00==?;?B?=;50:<?6AB1786<>>467@<&*..;>ABCB;;>?C?@CCBFE;=:=DF?>:@120:>><)D@AA><67;;<BDF@?EB9;F>C0&(1(=89<;;:-005$$49:676;?<A54A>>6FHE-.-1>/733.:C?6444=ACFG=>=CA6D4D4--.;6;<C@>320C5465$#%8:?44@FEA@5666=67+-DBED1-CCHH?38?NLMCCEA>@<<AADFB6??4;68&-;BCDFK@@<:-. +@SRR11410539.1509310 1509310/1 +GTTGTAGTTCGTTCCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTATACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGCGGTGATAGTGCAGAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTACGCAACTGCAGAAGCTGAACTTGCGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCCAGATGTAGAAACTAAAGATGTTGTTGAATGTAAATTGTCACATCAATCCTGACATAAAGTTACTGGCGATAGTTGCTTAATAACTATATGCTCACCTATAACAAAGTTGAAAAACATGACACCCCCGTGACCTTGGTGCTTGTATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTTATAGCAATACGTAACT ++ +&*.''&#',-45,'*'-4727ACDHF974'+'8A>31+.*/*9333867:90;255930644:;:6@>@,'&0.9481:>>917;384A67DBH@>>>@647?AAIGE:@CCGEAG@65AC=?AECH?::,),$%-0+12/<51+1()9@;D>GFD@A4F?AG?3($-$#*,-;9KGEGGCDADDWDC@BE11<>?<:<?A>85>?=<;.377ED:'(>>>-><=>:3>@1('45/0?A942-/.,>?BBD;<4%*$%,++1,,,1,4687@AB?@>D>B@>@;7<@BFD<@AHAB;AA:CC>=@>4443@6==1587439&-><<4/*5%584.3572)6A?LK=ED88@-(%&('.7<;A?B@;C=?%%,;C.<'2*+)*>>7>A@BG?B:5B8=(''*ADA@A;=*&&%+$009@>@?B78CGG793;77D>@76**4<>=EDKG=7>CI<@@A67CC<CF9?<<6+7;@<AB+4499FA)+4::E7622;=::;15035%%#'(&$$%%+,33?>?67*) +@SRR11410539.2471101 2471101/1 +GTTACTTCGTTTGATTACGTATTGCTAAGGTTAAACAGACGACTACAAAACGGAATCGACAGCACCTTAAGGATCGGTGCCAGAAACAGTCGCCTAAGTCAAATGACTTTAGATCGGCGTAATAACTATGGCCACCAGCTCCTTTATTACCGTTCTTACGAAGAAGAACCTTGCGGTAAGCCACTGGTATTTCGCCCACATGGGGACAAGGACACCAAGTGTCTCACCACTACGACCGTACTGAATGCCTTTGGGTTCTGCTACCAGCTCAACCATAACATGACCATGAGGTGCAGTTCGAGCATCCGAACATTTGATGAACACATAGGATGTTTCAAGTTGAGGCAAAACGCCTTTCAACTTCTACTAAGCCACAAGTGCCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCCTCCACCCGGAGTCCAAAGCCACGTACGAGCGTCGCGAAC ++ +(%%((*--9@6'-)*-01-<88<BCC;;2GJDGL@<E<B;EE=:>8967.(89>>?B@AAAADBBBOE./>B848'+5+&&'&--()'$*5)202/0/6=;<=>@=BHIAI;5/3$&('&$$##$..40+++*+89=,%8(0()=83:>>>>IB>;;-.>,:0543AB@>GKCF/89<?+B?4@@=@>?==CCBFEC8=''$'68A<CC0D>623<$46E603)*,.146499<@AA=B:8<:=>?;2400)&(9:>AB<=37628.73967;>*71285:==.7((*')2BAA=BCC>;;@A@000.'))$-.364<:;61'0$#)&.(5128@E22835B9?>?DDBI>??@==-3**'*42;>A>6FDC-3@AB<KB@@D<=CCACD<:AC;=IE?@HB??3A8EDEBC;//*%045:8?/%;4*/%3(&;01((<<'62518**51;?D:03-,& +@SRR11410539.519451 519451/1 +GTTGTGCTTCGTTCCGGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGCCTCATAAAACTCAGGTTCCAATACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTCTTATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATGGCTAAAGACACGAACCGTTCAATCATAAATTGTACCATCTGTTTTACGATATCATCTACAAAACAGCCTGACTAAGTTCTTGATGGATCTGGGTAAAGGAAGGTACATAATCATCACCCTGTTTAACTAGCATTGTATGTTGAGAGCAAAATTCATGAGGTCCTTTAGTAAAGGTCAGTCTCAGTCCAACATTTTGCTAGGTGCTGTCGATTTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAGC ++ +-%'%,+./,26;:)+%*(0+))0--,+++*'@IFDE?;:B=;@@9>9=9:71235<:<?A@?B?@=:8:898;;((;<<C>-A<=AE@),%%&%&)&&00)2A=@A==@8<>=<:<>@A9:;7<ABCE><;8689A>%&9<:>=@88<ECFD@A=A<9925671-A=HI@?D?2,07548FB<?;MJAEF>977..'5<40B=ABD=;;B.3.>>AB?A?BBA34<3?;:=5G>@HDDG4D?8:+'("$$&:=:.@?LG<<<888L580076683,((2$&-88:/?:;BBJ?3...40/05:=24<BDF:110,/$)$(+&''-3???FD?<>C>AE<9F?9:&<?6>595/>@?>?>@:;?=A@=A=CDFBA>>=8=446956/48;:9/39=@A?D?@>'**,-;55;4:2)-68;%02(;;>;=7>8?9:F<<F:<ARL:96800?=;?157:9;=A258CCMBA55997=A=@>@<>>::;:278>>:5*+)+&( +@SRR11410539.1228354 1228354/1 +CATTGTACTTCGTTCAGTTACGTATTTGCTAAGGTTAAAACAGACGACTACAAACAGAAGGATCGACAGCACCTTCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAGAATCGCCATGCCAGATGTTGATTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAGAATTTAAATGAATCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATAATAATATGGTACATTTGGCTAGAGTTTTATAAGCTGGCTTGATTGCCATAGTAATGGTGAGCAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAAAGGTCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTGCTTATTACGTAAC ++ +'$$%/3+:AD<>N21+4;;:8973249=?B/0-:>=,..*(&+&831.)%)01**&,&&*%220-<;FDFG<=E>89:CHFA-.GEDCA@?A:;89=2?@9AJ=5=@G==<GD>>BC>A?77=:9(4+8C;;**,,,5.>?>H99809&7*&&*2++*5???AF?@@CEEGHBC9?:>:<EG89;D7?FD@=FE)'$)8?JJHC@@>AA?<=;C@G:CGML??4G(8@8HD@CADJGE22(<869340167><<3<;**,-/11-(39<76'?<=EC@>?<>;;9/0&%-%54+2;CD==>H3226A;0?06E:0-%%*&&&)&&&:,+2>@?:;96>ABA,1510)4/0)6):<5665036144<@::4-4,478==?6=<;?=>F%@66/3D>CF37<HB>CEB@77724?A><=/2<=EHI?EC?=<<B7494ADC;>8032&+ACD>=EE/2658/;;;*'+3%%&4:@BBCD?A=DAGBCCB:>;9:8<?B>=>;@:90-//''(6>;9,/' +@SRR11410539.2220484 2220484/1 +ATCGGTATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTATTCTACACTCAGGGACCACCTGGTACTGGTAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAATGTAGTAGAATTATACCTGCGTGCTCGTGTAGGTGTTTTGATAAATTCAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCACATTGCCTGAGACGACAGCAGATATGATTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGATGTTGTCAATGCCAGATTACGTGCTAAACACTATGTGTACATTGGCGACCCTGCTCAATTACAGGTGCTGTCGATTCCGTTTGTAGTCTCTGTTTAACCTTAGCAATACGTAAC ++ +%'.-1/+(+%,-228@9:3:=@B;AEEBD3,<9:3CLHAE7>//>;ABBC@CHKH@9=<=98<?.=+:=BCEBA?=,;;<8(6269<:00@DCJFME??IGI8A-7;6<7<=DE>>D@?@@=D@A?BB@4ABCD>:CBBBGB:=,'8@988=68CBB@@C@B?A=C<BE;9?>@EB@BBGC?BDDD>'(976533;7(4.6'&-,245:;78==B9975,$*)&(((,099;9?4<=:<945...)/('28:7.3/,42-;=??E9'3<8:@D@@=84CECAA@B;<B?>:@54:;<8A<4,(((+,4ABC?C@@ACI46++CBEFCFC?@87:79D>C:??=A<6/%&88@99CB9@><::;BCBGEAB>:8751?CFFBEACACMI71*'*9>=9C?ABA98''8'.384=9>9==/58?@E>=39<<===;/39BAJLJGBEK<4838>4,09EGFFD>B=?<.69>IIN@DFD;:%1:999<=?=>>9300008,761''% +@SRR11410539.1892985 1892985/1 +CGGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACTAAACGGAATCGACAGCACCACACACGTGGTGTTTATTACCCTGACAAGTTTTCAGATCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAGAAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAAGTCTAACATAATAAGGGCTGGATTTTGGTACTACTTTAGATTCAGACCCGATCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACTAAAAGTTGGATGGAAAGTGAGTTCAGAGTAGGTGCTGTCGATTCCGTTTAACGTCGTCTGTTTAACCTTGTGCAGTAACTTT ++ +'#$''*'+--&,992-502.,)66:=9CF,,8>98;?54'('*'.115(,9<679::46763'*,*%%44;13BBA?;9=@@B@87.+&0203;T3;32+%4,71;=865DDDFDA8:;:9:3>:<IGBHECK4)<>FDHBJBOA6<GH=@>@A?BC?BDA=CC;:=9;;@:;=@<>BA?>BFA:8DEB<A;>=/B*@24ABA:29@=>CB7A<=?BC>BDBJI423:32:'')&3>C<EAGI;:B5,/4++$&)21>2;=>@@AD?'8.%,.98:8LKJ??CJ=;C62EGHAA2?<7$$.%'%$%3366>>=?BABB=CE>=@>?>::C?<;8:))>>3CD?A?6811-4+)'3587CEKG=>?DOK;D@FC@=9;G@GGLJ;;>=FIEEFEBE?=>5@BDCD?8-.((89A2:;>8:BD;>5874DFAED4A@=1B/-,:AACCB=>?@EG>>,774%&&%%'5<>B:DA;01/-**$'$'%%%%)&''& +@SRR11410539.1230662 1230662/1 +CATTGTACTTCGTTCCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTTTTGAAGAAACTGCGCTGTACCTTTTGTTAAATAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTATAATAAGTACAAGTATTTTAATTGGAGCAATGGATACAACTAACTACAGAGAAGCTGCTTGTTGTCATCTCGCAAGTAATGACTTCAGTATCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTGCAGAGGTGGTTTAGAAAAATAAGCATTCCATCTGGTAAAGTTGAGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACGTAACT ++ +)((,8:7<?A?:EC,/3?;5:9532039:?>>2AIIFIDA88>00%#%#%-051.1<A>>?FBCAECAAB=22332116.1*%%0')+06-*$((,28;?DB22-*&-'(9=;B7GJ::AD?44,&&5<>H>ECCDA<>@6:=:DA==..:AA<?9;653746457A/<;3327=ADCFFAHB=;3.&&%&<9%&%&59:=@CEC?A90(8))20&&8>><<:=8'-ABD=<@A>BF>89<:<A:))&')(##487>A6,;$%%&418,56??EDHDF@=D=63))%%9:DCC<=9:7?866/3-943432<&12345@,,9;8->C?ALH2C'?<H<0+$$/1+,/-8?7D<<>=>@06/0*)5;;G;:FA40,)0457722/9;0CAD=8689;D;7*&1?@C9<=BJHIAC>BBEBAB9=<:<BHFF@AC,%777(6BCBE;7B>AHC<?<FBE?::::>9:9210387;2200'*CEB=;((#% +@SRR11410539.1607630 1607630/1 +GTTGTACTTCGTTCAGTTACGTATTGTAAAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTCTGAACTCACTTTCCATCCAGCTTTTGTTGTTTTTGTATTAATAAACACCCAAAAATGGATTCATTACAATTGAAATTCACAGACTTTAATAACAACATTAGTAGCGTTATTAACAATAAGTAGGGACTGGATCTTCGAATCTAAGAAGTAGTACCAAAAATAGCCTATTACTGTATTAGACTTCTCAGTGGAAGCAAAATAAACACCATCATTAAATGGTAGGACAGGGTTATCAAAGCCCTCTTGTACCATTGGTCCCAGAAAGACATGTATAGCATGGAACCAAGTAACATTGGAAAAGAAAGGTAAGAACAAGTCCTGAGTTGAATGTAAAACTGAGGATCTGAAAAACTTTGTCAGGGTAATGGCACCACGTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATAGTAACT ++ +%24*76:>4=7K=82<>8103;=<;*6>@*'%(>JIDH?:B;AB>D?A=<>>4.236?:69888?@B?>7-)@?@ECC>B@+9BCD;5@8802&''-;<9>D9C<DDC;)%#$;?DEF?90/21?@>>82'*$%'0564+(()$'**,6ADBADCDCBLMGCFD::<89H@=2*98<6;?JGFAD98.$$,1137=428/$$$'&$$+*#&&30>277+,,&''&&$%%&&&&%('&(%+/0,%$(')'167=9BLH?;45.:157;:9?@DB<45.0157A;@>FEDH6>:<70A<@)7&*:82(09++&'-,+.'%&&%%')0)0,28:=+<)(('362:68<>75<<8?<@;6*8-.18=@A88>=?@GK18E;*248()27<>79867:7:;=BB>>A86859?D>@A?=:608,&))%-%:;<C:87/4)*+''&$*0/<?C;<>=3,:-C<<B@:>ACGI;<8FFL?C26=<9;<BBAAD>>/:5736>2.&&',50&, +@SRR11410539.2265575 2265575/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGAATCGACAGCACCTACTGTGTTATGTATGCATCAACTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAGTTTATTATGGTAATGCTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATACTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGGCCTTTGGCCTCTTTTGTTTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAACCATACT ++ +''..8;9;=@85H=>:<GHG=ACGEJ<<A235EGDDG=83471557::9=</7((069=D0:->@ECHFEE<:ABCCBCB?<;7:9@$%<?A:12EG=@C?8;;&&/&9DGGCAC?:@BEEM>???G???=;B:;?./<98A?::30'(><+/16,9((-:BEBD;9:=?DGDDCEG79HFCA;;94?@KHGDEE6<=122+*<?93,>340=;:>AC?@B>?7,./8:<7:?@<=:;67@=J?7>?>A8CC@DIC?7-61E@<EAACC=0-(;4387/0AAMIH9983<527<?KDJ<EAHD>?<>;999>?=>:>8899<<6B@ECPGALEAAB?B;:./2477/.9336:7884,)(.+''/1&4.46/.2BFDDCC-/$$#.+4?DB@-*)(()')+*',=;<<85::BLE9==@>/&6=?$%<;44;4/067=>@89CEAC9E@?C?I8=FDG??>864+DD?@4:=ID>989:=<@AAABEEF:@933*+$$%',)%## +@SRR11410539.2236911 2236911/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACAAACTGCCACCATCACAGCCAGGCAAGGATACAAGGTTAGATAGCACTCTAGTGTCAAATCTACAAACAATGGAATTAGCAGGATATCTATCGACATTGCAATTCCAAAATAGGCCCTACACCATCTGTGAATTTGTCAGAATGTGTGGCATAAGAATAGAATAATTCTTCTATTTTATAAGCTTTGTCACTACAAGGCTGTGCATCATAGAACTTCAAAATTTCTACATCGGCTTGAGTACACACTTAATAGCTTTAGGGTTACCAATGTCGTGAACTGGGAATTTGTCTGCTAATAATGCAGCTTTAACAACCATGTGTTGAACCTTTCTACAAGCCGCATTAATCTTCCAGTTTCATCACCAATTATAGGATATTCAATAGTCCAGTCAACACGCTTAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTT ++ +%$&'3630:09;A:A=>@@1<==:?B?C=>>%-1DD?B/,4019.-,+//479:5;6=;>><:A=DBGFKA?A@+6A9CCE??EBDD.<$;:>AB6,-&'%$%&./(BE4)+--,36<><:2)4=,'/'((6;?<A?C@>BB?ACHAC34*1,;>7986??<89@>=86:6A;<<?%-?@><0.,)(('.0/85:C:C>7@98;BBE>89C15D;<;8':;3:<23*3C+>)8<:6909=?>A@=CCA<@=66*((-351;0.9;:68=;<<4/*90/14/4)*.01(0''&&3:CAA7B5/;*,$$$%$-'$+*1:9:;22.(.157827AB@CAECGB>>85.00(*(('+'156;E<>B@?=5CEB;;836*,+2359:=23:72++3-./12?>=>@F=?H>FH>AADGEIE>@;<<9)+14==;;>@518?AABCFDGEEA@??<A>=?A@33B;3+>79A/:62248:><<(:45;;>?AABGC<=>OKKD@B=8=>>A9;870 +@SRR11410539.1158374 1158374/1 +CAAGCGTACTTCGTTCAGTTACCTATTGCTAAGGTTAAACAGACGACTACAAACAAAATCGACAGCACCTCATGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTAGAACAACTTCAGAATCACCATTAGCAACAACCTGCTCATAAGCTTCTTGAGCAGTAGCAAAGCTGCATATGATGGAAGGAACTAAACTCTGGGCTATAGCTTGTAAGGTTGCCCACATGTCCAGCATTTCTTCACAAAGCTTGTTTATGTCTACAGCACCCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTTCAAAGAGGCTTCAGTAGTATCTTTAGCTAAGAAGAATGTCATTGTGTAACTGGACACATTGAGCCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAGTAAGACTACTGATGTGCAAGGTGCTGGTAGTCGTGTTTAACTTTAGCAATACGTAACT ++ +$$%"$%)*/05;<HG<7:E:04/:127=>A892CHGGJA6<9<C<<::;933*/&),89?<E+;%)%77@9.>AC=CDIF;@GM;@;@GJDD08;;@KA=DDCB>FEHG?BC6)5?FD>HFB;;9?>>0?+<HD@@AE93A67B952.//,03*322;%%@@D?@B=6334/''.57=A8EC@E7E:320/$&-&6;>3EECA?A49><48;8II@>640)+75BI@DG>@=.0%&.)24*))'%$#%&--5=>A@EE3ACC?=:;=-2EKL<EDCF=B<>:?@B<<;GGHHBEBD35246&>HJOJ@C:<633=47=A;D>B?AB@ED)/$'*&%,3777457ABC>?7/GGA>0&>@B*,(*)?>?>@9@D@=<;;A@B?CCD5=8/2;:?753$$$)$&:55@:((11<JFHD@?H?=?.C@@540'4689<::;8%&7=@B?A6?>;AC?82>;><=0A?=73%&#%360%*1/3B::7:@6/997/*)&++-.&% +@SRR11410539.292614 292614/1 +TGTTGTAGCTAGTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGGTTCTGGCAATTGGTGTAAAGGTAAACGAAACTGTATAGTTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCATCCACACTACAATTCAATTAAAAGGTGCTGATTTTCTAGGCTCCTACTCTAATATACCATTTAGAATAGAAGTGAATAGGACACGGGTCATCAACTACATATGGTTGATGTTAGGTACATGACTGTAAACTACATTCTTGGTGAAATGCAGCTACAGTTGTGATGATTCCTAAGAAAACAAGAATTTCATGTTCGTTTAGGCGTGACAGATTTCCATTATGATCTTGCAGTTCAAGAGTGAGCAAAGATAATAAGCATAATTAAAACAAGGAATAGCAGAAAGGCTA ++ +$&%%$##$$(',(+<83;D?4?ABD<;438<:1@FGGH3<77;0>CCF>>EGC;'(455<>?)':<=C8C>AEM-29<<;+-+0$%9-,67-+9B?B>:&&*:=@>9(')%%$./26=BA=BBDAA==B>BADA)*8>?>QJ;<B?A@5A,@@;?A//</+*%$&'&)&)A?=@E=>2'3,?8;06'(0F-,$..1:969@'%385..8111-)6;;9H4?K>(/(03A>;B?>@CBD?<;>=::72@?@?>AD=BBE:;GIC@E@2-#'-2++8:;;8=A?@EGAEEE@;:BCD/6@??+B?@D=.'.%$$$5;<BBBFEBHF)*;554?ADA:;<35A>AE<848D948>>16*03$332)2+%>@<$=;9=A@@=9:A<%&&&/-:&'&/361-'2>>9+?9**,-22@HF?A@CBD@8;337:29<78:''AA<4:85' +@SRR11410539.2323656 2323656/1 +CAATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGGTCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAATATACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAACATGAGCAGGCTGTTGCTAATGGTGATTCTGAGATTGTTCTTAAAAAGTTGAAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGAGGTGCTGTCGATTCCGTTTGTAGTCGTGTGTTGTTTTAACTATAGCAATACGTAACTTA ++ +,$(*,++=@C@ALC929<???ADHCD:78014DJHGH><7@:;<7=;65?>396<;D=?BCBEACF?=D<40C72A67:=97<@B>>A8.3*?*2HD;A66CCGBD8<24>7C>>B=B??@9>A=:<=<;04==@F69'()*+,'$-2;:;=>=<7:7?8>BE57,**.4-69BB30CB>=97,,/0.,099>?AA?AOGCFBCEKKFCG?A>>AC99??D@J=<BEG<BA>D=;::;=<:;<3;4:>>>DFB9=?C=>>;.4<,6-14>7:8D89A:CD@A=:>=6-%')+667;AA683686:9532?>@BAADD>@>>C@CA=?:66/0>8=?ABKKGIJDBDBC6>45%0-&&:>>:?6199A=;=-+1:--039EG@?CB??:111:BJHDHDEFD4+759:5)%*?CNLBDDK<@H@FC>KLGAHGIHDEDFED>?=B0598;-,=?:<5./4<::D?9>=9::8<7>:C;9B>8.&%&)'*.,::?>81+/*?A?@A922942()%&'( +@SRR11410539.44699 44699/1 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+-(%#&&&8;;>>I>8,.38BE=JIJG<>;+,0>BBDF8;55?<:939@:<<8)))-&--8<@7969<;9510*6&&2---9///((,455989<AEB>;98<<')/,,5689<?AA6>?A)C>ED?AGD5++.;4(.*/HD?@DBACC?>6?3239A6?B?E@=A:-'*5=ED>?,.7.=<@E-,(.,%)#%$+$*89<=;<9116/3+(2&'(49:;79<</<749;==MK@CA>KKP>00/CDB@:978/=@B=?.<)7:=>@996/-124..30)(&&(.(+(68=;4;:A54-&,56;DACCI?@<<<<3;&%%;?=<;;+.);--65>>A>BEFI+D@@DGEHJ20569.1.69:<,&%%64=?=B6869FC<>8GD>A::BHGEIDNA>?<<C>B@<>EA<<;?:;967><A3</;;@<?>A@BDBC4?0FF0ECCBBFGH@I<3B@@F@;BDCCD?B@JHE>;36<?;993477>AABB@?((&%%---.6=B@;&%& +@SRR11410539.864290 864290/1 +CTGATGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCGCTTCTAAGTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTATTATGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAAGTATAGAATTTCTTAAGAGAGAGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCCACCCTAGATGATAAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTAGAGAGAAGTGAGGACTAGTAAGGTGTTTACAGTGAACAACATTAACCTCCACACGCAAGTTGGCGAGGTGCTGTCGATTCCATTTGTAGTCGTCTGTTTGTAACCTTAGCAATATAT ++ +)$&$%&/-11234?--&4+/*9:>A=@-4+.*2=>@C796:69885+**23*.%'&(.730>;BC?H=G?@>@J9:HM:AE8EJEFGE9<BA>,757.<3?99/90300?1++((,/,,&'/<?@:9@?BB@>C+83?HHE??J=>@<=BGD?FB?<=@?=;BC<=B@C@AB=GA9H6C7EHJGA?=9:GKB7>B@E>>5--/&',&0+0/7;@@@@>GK;:G=?F?$''6(89'3::=)-0139?:;A?>@GC@<5=1,2979735,/):=+8)*,(+A=:=''02&&'..?77<68=66547>8@<==:<93-)677++0,,,&'-(%&$(,2:993**+%$$%&)+'-4-1025969;D==AF=>BAEGF?>??ABBEFI>DC10,/5<;69;>@@AB9(-/$978)6;;FBB=?8>@&&,:34@556=<488==5)1.(4/.,;<(((,-9?<:==@9;11/4).,36=??=>797:>):<96'(%%%)&&&))/'$-0'% +@SRR11410539.98118 98118/1 +GTAATAAGCACAGTTGATTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCTACAGTCATGTAGTTGCCAGCTTTAATACTACTATTCCTTATGTCATTCACTGTGCTCTCGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTAATTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTCTTTTTTACTTTCATTCAGAGTGGATGGTTATGTTCACACCTTTAAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTAATTGGTTCTTTAGTAATTACCTTAAAGAGACGTGTAGTCTTTAATGGTGTTTCTTTAGTACTTTTAAGGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAAATGTATCTAAAGTTGTGTGTGATCATGCTGGTGCTGTCAATTCGGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTA ++ +)+&'&%%))()%.')(%()**/,+,168>;;(-66@BC;<8;>CCFFEEFG9<367@=<991+&$'-425<926*83<==1+&%%%134010..96*/7::%(*2<;?:989<=-,-+)%122(%&238<;:--84@68D@BFB<=@AFHBGFI48AD>?8543+(*++4335578;>@@@9;><56>@CJHC=@8:5E<ADEEEA8>;@891%8===41&$')'%&11++)();9;=B,0<:6')<9C<;C89D@9%%%%%709;5C4<?FG@?6,-,.+579=CD>B?BDKCCAECH7;--;<,7<BCE5?6&9.39;=F9<>AA;A:;8:5;4(=AB2+5<;=.),0++**%')011%'98371:576><A<;BCA1%&&-$'(0*178629:<,>4))4407AAD4>C<?@???50@9;<>;B=::-5-/-++%'#'#%$$&%#%(+1/6;55;#�>,2FF@;?B=;;46:17;9:89;;;2A(.:80/*&($ +@SRR11410539.97901 97901/1 +GATGTACTTCAGTTTCGGTTACACGTATTGCTAAGGGTTGGCAGACGACTACAAACGGAATCGACACACCTTGCCACAGGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAGATTATCTGGCTAGTGGGGGACAACCGATATGGTGTGTTAGATGTTGTGTACACACTGGTACTGAAGTCAAGGCAATAACAGTTACACCGGAAGCCAATGTGGATCAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTGCTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTCTTGTCTCAAGGTATGTGGAAAAGGTTAGGTGCTTTCCCATCGATTCCCGGATCGATGTTTTAACCTTAGCAATACGTAA ++ +)#&''%**,&%+690+%-9:3')6.0/;=;;=:;)/$2-(+))&*)2235..34'-%)%<86,+&%%%--//'&&$$%-,'%)**;-9:79.2/*+/.2116/0+2&&+&-%10.-0;:;:D<C@=B@7FBEC>@JGE>5@9;=IH<;9?<A98E8?A6608:7&%&&0778*5:82;;9,3>57'<3689A98,-(&*+/(,$%,'//5590<6513057=9-/<;::9=<:81,&$,+2')%0453///./8063.<1:6;18'&$&(%$'(*+1-<*239:<AGE01<8:77+07;9B=;</251'%$'*&(**3=9@?70:3;/58;6((@6777898+/'35/8=AA6900>?>KR6&'77))553,)6:9:92,-543+/%&((('%&)+9=ADCBB?;2*869=HGJ>349((+,-983441-;35+&&'&++'$$#+7;:33==>.35(9=<8-,/+*').3$&%+.26224())$&$-.$$-$+,0-&'&'%((*.3399210&' +@SRR11410539.822872 822872/1 +CGATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATCTCTTCTAAAAAACTTTGTATTGCATAGACCCGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTGCAGAAATTGACCCTAAGTTGGACAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTAGCAATACAAT ++ 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+GGTGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTTGCCTTGGTGATATTGCTAGAGACCTCATTGTGCACAAAGTTTAACGGCCTTACTGTTTCACTTTGCACAGATGAAATGATTACTCCAATACACTTCTGCACTGTTAGCCGGGGTACAATCACTTCTGGTTGGACCTTTAGTTATAGTGCTGCGTCTAAATACCATTTGCTAATACCAAATGGCTTATGATTTAATAGTATTGGAGTTTGCCGGAATGTTCTCTATGAGAACCAAAAATTGATTACCAAGCAAATTTAATAGTGCTATTGGCGAATTCAAGACTCACTTTCTTCCACAGCAAGGTGCGCGGAAAACTTCAAGATATTGGTCAACCAAAATGCTAAGCTTCAAACAGCATTAAACAGCTTAGCTCCAAGGTGCTGTCGATTCC ++ +%%&&(+/.45=89B@<7:FFEECCHEB:<B12-<?DCF6BACBA?>:>:=>@6@:=:B<>98)4':=:<7A?3/1///.:96*&'.%%--,%&&,-0+%*,1907,,-,&/0<?:40.2753/&*',&'%$#$%&(%+*,++:1/+:::99;.%1-'4244)+%&457362,),*&('*%,+0,(3((A@9A@>E7C369..).22347.$+%)#%$%&&%&%)$+&)268868;9>>G9:3&3---33385())))/.$$#%&79*-%+"$'*,$/&*(%#$#'+6()==;727+684.**,-77,-()061/-/,+'&$'(*9@BA56($3531957:*+&%&,26@:<>>9=74367),<=35(*5%4*+(&($$$$.3-,06=?4,351)%%$&159A448<CB<951%$./&((*$$##%%%$'+-,.)(0%))++.45)7//-,>5584.2-+36&& +@SRR11410539.1893571 1893571/1 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+CGATGTACTTCGTTCCAGTTACGTATTGCTAAGGTTAAACAGACGACCCCCTAAACAGGAATCGACAGCACCTGGTGTTGTTGGAGAAGGTTCGAAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCATATTATTTTGGCATCTTTCTCCACTTCACAAGTACTTTAGGAAACTGTGAAAAGAGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCCTCTTTATGCATTTGCATCAGGAGCTGCTCGTGTTGTACGATCATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAAGGCCGCTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAGCA ++ +%'%%%%&'-/-7>@%(%357.+'/(/2=B8<;+=GBAEC685970.-'''&)574)%+-*:84=CFFCAB=:B++>;IKDFF<??B*<,:<,+%%,%(&1++38:?BDAFG>BGEAE851:C<;8<:;LK?-)=/2-8@537?;8,+)())-.1+1=>9@CD623&&''661((0''/,+0&,87;5;733*/49?@A?4-4%,$$$'+%$./+418::5.2*/6757(1./G@%3/><?F:=;?C@;GOO5BIJ>EDGGAB@669%)-;@B66:B7-4<C??FIQB@B>@?A?>JN?,.?>?A=?>:AK3,,'76=><>78/4AEGC==8:;>-&%31/-.9<==9710444857<=>>-,,:9>?A-.././.%$9;?@BE97A=69%(%(320)-&)/1<;.0-'+''===4/-=;ADBC6CDDCC<@B;;A><?GFDCME?<116/'01.41&DFF&6C1017;==>>?;?=C@IB?>;63,4;;=895$%249;>2==>94/*')$$# +@SRR11410539.2485496 2485496/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTGGTCAAGGTACTCAATGGTCTTTGTTCTTTTTTGTATGAAAATGCCTTTTTACCTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATATACTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTTAAGCTAAAAGACATGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGG ++ 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1317217/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAACCTTTCCACATACCGCAGACGGTACAGACTGTGTTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGTACATACTTACCTTTTAAGTCACAAAATCCTTTAGGATTTGGATGATCTATGTGGCAACGGCAGTACAGACAACACGATGCACCACCAAAGGATTCTTGATCCATATTGGCTTCCGGTGTAACTGTTATTGCCTGACCAGTACCGGTGTGTGTACACAACATCTTAACACAATTAGTGATTGGTTGTCCCCACTAGCTAGATAATCTTTGTAAGCTTTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGTAACTTTC ++ +0++-.4/79:7@HG82BJH4>@<>=>:;B==&@CA;<.>>?B=A=+:;966'3(-)347<==6608>?G@@89663,236<@A:46E<>9B-47*@AA94A<9<+)%%$$&'(&+44:@::)12-@=@;>--0=:<@:?@9DE5.=<>31:97242+58;:@C*(77:<;>?:>BC?FGB>**2*+,*+3)8877;9AC@6;,+$&499@67E?;9438+0(0(9/06=?DFD@65;?ED@GG),;49<99?GA=@D1BEBA8;9999?59=>>01:@@D3++/@@@@GCBA05:312$-44&+4=885B@89B>AEKA9:>6A998:21=C?J@03@@933?<<:;@A;@:A;FD>?<?BAD;8334///,%3.7*<BCGCA978=IKC5?=F=E=<037BC78@HB@CIC?<;67,+,,,886=C:?<=DC<@227<:72:ABD>;@8067<8>EE0:@A8947A@@A>:A??DA=<588<++*)586:=<<6:@<=CAD2=''<=9)....19:5694' +@SRR11410539.724924 724924/1 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+(-.-89?65E7<%-55=;9;<014>:AA&4F??ADE?<;A89;5<<;786&).3./316)+96:>;<=?8?BDD;B%+2D-@FEA;596=>0/29+=><@@?EF88548;+,&'*3-099;=782*?ADAB<?>>85467897,3016B;=<99CAH>@=CH@GJH@/98<<B@@A899A=?B=>77A??=A,-@'(850*,*(-,,-0110==))0.///4428=6253>A?CC<;;A=>@=?8::<;EA;=,ABF@=>>:4*/'.%((,++2;;9IJ<;A;8@B84<2-1(,2-3341*%'$$5379<A>EDA<C<:66;+6=>830343>;;A@9:?@=;AAADFB2714299>.)7345))*=B>?ANIAC@B:CCBNN<2*&BD>CC70B>A<<B=7=<2*:>F;<:-1895$..780*,<<B88;<GG@EFH7)'*(5()4226<GBE@?=??A876:AAA>@;>@::::>;DCI<:D@9:63?11?ACBB:,*.699CC>C=::7+$ +@SRR11410539.1888160 1888160/1 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGGACGACTACAAACGGAATCGACAGCACCTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAGATCGCTGAGATTCTAAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACCAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGGGAAAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTGCTGGCTAT ++ 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+CATTGTACTTCGTTCGGTTACATGTACTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTGGGCGACGACTTAGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAATTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCCAGCCTTCTAGCACGTGCTGGTAAGCTTCATGCACTTTGTCGAACAACTGGACTTTATTGACACTAAGAGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACCTGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTAGGTGCTGTCGATTCGGGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTA ++ +#$%%)(6;CD@AC7@*1;;&%'$$+%7=891BEDCF1@=??ACF=<:934+3/20662'+69/<=?@HD:@F?@7DE=0=4<EC>AGBEBA>62<72%&,,8+++((8=36737;>3358?=AB<$(<@?@:=***)($%&****..5.0C=44=4<>GL=A770=1?A?ABDG@B9ABKKD>@8822((%*37?CBC>EDC)1::>=?58@<:52'&&333'+337=4.1/36:66A33BA;;8D=?>?33@445..00(3(3*-0::6>AFEFIEBD=<;>;658-+35=ABDIL708&30))'&0922,.-,-0??AB79?>;0=ACAB6)&2;@BJ3.<..6<2388;<@..1;==4B?3*'18;1)1*8;473747:7:91*12EDDHHCEEB?@B8@>32271''''')%&((7:06*1C><43200*%$)36<4@/34:)2--?@=:=?;---.1''5223&)*$$&&).17916:4A?B>=>?>>=<24?A@B=42%("'$ +@SRR11410539.1895395 1895395/1 +TGATGTACTTCGTTCAGTACGTATTGCTAAGGGTTAACGAACGACTGGCTGGAATCGACAGCACCTTGAGGAGCCTTGAATACCAAAAGATCACATTGGCACCCGCAATCCTGCCTTTAATGCTGCAATCGTGCTACAACTTCCTCAAAGACAACATTGCCAAAGAGCTTCTACGCAGAGGAGCAGAGGCGGCAGTCAAGCCTCTTCGTTATCATCCGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTGGGGGGAACTTCTCCTGCTAGAATGGCTAGCAATGGCAGTGATGCTGCTCTTGCTTTGCTGCGCTTGACAGTTAGATTCAACGAGGAGGCAAATGTCTGGTAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGTGAAGTGAAGCCTCGGCAAAGAATACGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACAGCCTCTTTTTTCA ++ +#($$$%%,0448=9,(&33;<CDHG@A@78.,66-'&&$#*<951/'(&'+-)/4/1)0.479:;:@DB9**:=>=6-+0-+&089;+&*6=;C>?BAGIDFHI=BAB=?B?7)($$$59780.8=6=::.7'&:25446<>4845./%):@==://1/01BB-(+GBFF)58A=?98.5/*/5:00881453,*&<8:;;>:<;/&%"&%''*%%($,229=1812<;=>;>$&()05;>A;>A@-;42%./2-*(0(+)**&)*''',1*3-/6530%+6;<=-));,+%)'&%%)./+&&68?F7F@7111=6-.'$&%&'+&'$%$%%%$"%(*))'$*%%*+1(+<96-/&'**,-,(68++<34C12>:::?;>=?'68=:>??=@A5=BB;:6)$%&%$$$,''656;;<<0+(1.+$&'&&+,*.6721B1)=9;GE18.78;.788;5079<148674(+('$$$(($$(%$##)(%&&%$$$% +@SRR11410539.1455590 1455590/1 +CAAGTGTACTTCGTTCCAGTTACGTATTGCTAAGGACAAACAGACGACTACAAACGAATCGACAGCACCTAGCCTCATAAAACTCAGGTTCCCCAATACCTTGAAGTATTTATCATTAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGCTTTCTTATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACGAACCGTTCAATCATAAGTGTACCATCTGTTTTTACGATATCATCTACAAAACAGCCGGCCCTAGGATTCTTGATGGATCTGGGTAGGGAAGGTACATAATCATCTGCAGCAACATTAACATGTTTGAGAGCAAGAATTCATGAGGTCCTTTAGTAGGTCAGTCTCAGTCCAACTTATTTGCTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&%'#)*679;=@=A>%*8;;A=<798444:6+,'5&%+1%;9:;7<8;73956+*&)+009:>?82;8',<*;:>>44@BAG@+38/>;6)000DFD>586864.+*&,..-8969:71444,4+*),7?A4=?99B?>8@;;:>=<AB>8=?D<?>0/%%(*00))$#$%D<><8;=922462)*,1/:79:99+;4088.*/%,.042/2+.6;=H9<6ACF@78,&*(14&@02106</9@;?@F=D<=;EL=:509A>?:42:@+567<845575C@><?9D@FE;A<CA>=:==AB>?@=B8+?AAC64605579>7<0:05453?KHFB28:=;?A955)1%89,-0*3,/8;56:8)'/'%+-%'$$+&%*%%&'..:<2++),%512%*(167+)'%2789?<@EC?+?*D;@5879:==:44;+,)**<DEF657%':79@949ACMB;=:DBK@ADB;<8;@A;@B>88,/,02,0114>943%&&& +@SRR11410539.2193881 2193881/1 +GTTGTACTTTAGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTACTACAGTCAGCTTATGTGTCAGCCTATACTGTTCGTCAGGCATTAGTGTCTGATGTTGAGTATACGGAAATGCAGTTAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTAACGACCTGTGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCACATTTAACATCGGCAAGGGTTTGTTATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCGCTTGCATTAGGTGCTGTCGATTCCGTTTGTGATCGTCTGATTTGTGCCGGGATTACGTAACTTA ++ +%%&,((%%&(():;@<<FF18?FDDD40??@-GPHGJC==<2@AACDB>DGC>2.4+;;<@D<8CBC?=8535?:6?=BCA?@@A>?,0,12'=<;B@@@DC?5'&00238733;?@FD>@DHBEC:/8&51'$$3'(+())),*,/5)*/.089792.'-24@@;@>--5:A?BCL:CC?C229999::5,++++*-'(1312+63;<=;=79:95>:?:D67>?5(.$$$)+*)'#'04:45+4268:E@00714<>C=CD<?9:>?1)+%%&$&'%%$&*/.6:2217>>C=257)5:9:9;;0DEBDGD==BD2AECABC3EB=:@<><=720444=>9B1@=:A;0)<0IDA722.4/B;?=8:67<;C?@@C@('&'$%%2:98:8=?@/+,-5+4017CB=87@ADEJH:95;>;89GJCB?HEB2822((1*/'&,,#$+,1/47C<=A@>BA@=@;>?D=A8*'$&')&:/52757,$###(*)%+29>8765%%,% +@SRR11410539.2322211 2322211/1 +GTTGTACTTCGTTCAGTTACGTATTGTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGCGGCCTTCTGTAAAACACGCACAGAATTTTAAGAACAGTTTCAAGTGCGGGAGAAAATTGATCAACAACACGAAGCGACTCTGATGCAAATGCATGAGGACTCAGTATTGATTTCTGTTCTCAGTATTCAGGCACCTTTTTTAGCTTTTCCTTTTTGTAACTTTAAAATTACCACAGAGTTCATTGTTTGTTTGAATGCTTTACCAATCAAACCTTTCACAGTTTCCACAAAAGCACTTGTAAGGAAGCAGAAAAAAGATGCCAAAAATAATGGCGATCTCTTCATTAAGTTTAAAGTCACCAACAATATTGATGTTGACTTTCTCTTTTGGGTATTTCAAGAAGGTTGTCATTAAGACCTTGAACCTTCTCCAACAACACCAGCAATACGTAAC ++ +(+,+,(%%*@@G1-&85686.?89:(&&'4=EE=?58:7932/,*(-/238365?=ABHCFAAG@?F>C4C*29>:;8,-/?BGFC><9;6798/&&)%%#&%(%,$'2B4A2.&;164<,:)539..3-,+,#$$(()63,+%*.''08??@>D?EFGH211-(#%'+%%*)($(&,,+&'+1.)&*+$$&,(47<,9:;BAE??DDHD;4-5<===G<=CAFDE>;3.)=@>HN;3254567206$(%+&&#%)&)A7@BA22;822794/$$((%58;@4814<7987>AA@1408:;3.$.(&&&%+##'$-)-))(+*@53)&3$$%)7965A=7CD1271<=@246<@BGH==8=?801$>?BFAA755<AAE>DA:;81?A>AFD?>F@G>>5,)43:?C/?$%/2,4>;/,25;>@3332&%$$*#078787:,970+;<2@@:F0@DEE?CC>+/& +@SRR11410539.881123 881123/1 +CAGTAACCTTCGTTCCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAATCGACAGCACCTAGCAGCATCTACAACAAGCACGAAAGATAATACAGTTGAATTGGCGAGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAGCTAAACTACCAAGTACCATACCTCTTTAGGTTGTTTTAAATCCTTTAAATAAAATATCATCTTACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCTACAAGGTGGTTCCAGTTCTGTATAGATAGTACCAGTTCCATCCTCTTAGGGAAGTCTAGCCCATTTCAATCCTGTAAATCGGATAACAGTGCAAGTACAAACCTACCTCCCTTTGTTGTGTTGTAGTAAGCCCCAACGCATTGTCATCAGTGCAAACCAGGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTATGTCGTCTGTTTAGCCTTAACTACGTAT ++ +(&%+#$#$#%(3?<*11799..'+,,1088$%.A@;;>;7..4(1&79-,*-&/369:9;>EBBAC@?93-05134;;B.%4++/**&,)-&&:'-EHCDGE@<?NH777=?689-,A>;<?AC=4AA773583>CCI=>G31461-)26<=55+-*)%+7;<;;:56?34.=5BB:10&+.568117;@B=B9969:<;=?@F776&$++*&'&%%*%%#$$#'+95><=7223-.3*+6-8'):38?B@8GHEC@=:=78<AADC>6<:@=1<9/*:9@4B28+.*67?>=;027''0+;>7,3//%)$16*+',5.+)*.-37''*-,628?9C=AAC=?746C=A%&)==5576;;0*:8;5;$$&<(EA<787.+$%$*'(01%%$$%(.85:===@)&?7A@<444.'+&++'(B:A;:316567;<.(;=3079@E=76D4>>9=<&&.;D@DEC>@>;8=;=>FD+#%%05=>G>@88,'%$&$&%&&&$+$%#% +@SRR11410539.2128799 2128799/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTCCTTTATCAGAACCAGCACCAAAATGTACTTAACTCTCATAAACAGGGTACAGCTAATGTTAATGTGTTTAAATATTGACACAGTTGAGTATATTTTGCGACGTCATCATTATGCCTTTAGGTAATGTTGCACTATCACCACATTTGAAGGTCACACTTTCTAATAGCATTCTTTGCATTTTGTAAAGATTAGGCATAGCAACACCCGGTTGCCACGCTTGACTAGATTGTAATTTTGGGTAAAATGTTTCTACATGGCCATCTTTACACCAAAGCATAAATGAAATTTCTGTATAGTCAATAGTCACTTTGACAACCTTAGAAACTACAGATAAATCTTGGGATTTTATTATTTCAACAAAATCATCAAACAATAAATCAATAACAGAACACACACACTTAGATGAACCTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACAATAATAAC ++ +$%%&-2/;B;=>F270:FD@<9CB>D@@>-.?@HCBD11()/6999:4.::31&)%+-65:24/74179).:==EC*&;>7?DD?N:GIFAGFIK?@:;''(;=66&(+&(+,*(/%%%+&-111657>AA>35/0@<;<@8;;9DBA26,6ACEG=8-2;AGEC>CD::32.(03767232-0077890*10-:<56@B@BG@B72920/$''$'+--9-9399:>8886?49@1B=BDGDAGJI@CA@BPH>;47867600*6=B<:9998>ABCA.5?FEBF4A56;::;5255-1:77===AIGEBJ==E@E:<89>?8:<E?<<<>C=?DB16=20AHIJB<:::=2*B6<A3;B@=?;B<@;8>DF?C5.;=33BCDA=B@7:8=FCE??=@B>>;FA>CH>??;8;<:FHHHACB@GDEB,-7==A@;>1+>.0'+058<=?;A<<;><9<760.9$4&/47565:39977<<<?B3?2@;<<G@:<<?AA675<=542,+04423-<=96=><;>>)'&&&$$%$&*' +@SRR11410539.2374698 2374698/1 +GTTAATACTTCGTTCAGTTGCATATTGCTAAGGTTAAACGGAGCATTGCAAACGGAATCGACAGCTTCCTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGATATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAGTGCTTATATCATTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTAGCAACGTAAC ++ +&$%#$'&23538H?92:68&%#)))+-3;79,H@;BD;=%+%%9+,/'*/0-+69=<559-+.&#$$$$$(%+3;<?AE><A8-4(('/=<?;<<?E?9;999>AA:?DFDF:=;??=>9>>9<@D=>=;94<=C>BCB9950.,'4')?@BC:;>=76FD@@1,4?>A>1(232)*'/+,1869>?=8:01554?CC@KFF?AEDG=DAC;;=86>166553/045>EHD@?46@?@FD?ALG@@B@9D77@8:EF@@:D>>@@AC@<;=A>))*$&5%%%%)5.)$$6=CC??DK70;<GGE?@EDDEHACFH<=IL?SKEI>EGIJKEF=728$22:A73=6288=@JJECDA34@@@AK;=BDE>>@;;=BA913B/A967=:BDAA82;??=ACALK>GIDGF@CH<&9C@8:8,&>)@A0,4@@==8<<GCAJDH@@0?/:@DDE3.6<;<;((*&(2.&+-37452(&#$*&+$$'&+&&& +@SRR11410539.850400 850400/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAGCAGACGACTACAAACGGAATCGACAGCACCTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTACCCAGTTAAAATGTTTGAGATACTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAGAAGCACTGGTGCAACTGCAGAAGCTGAACTTGCAAGGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAGCTATATGCTCACCTACATAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCTTAGCAATACATCAAC ++ 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+CGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACCGTCGACAGCACCTAGCCTCATAAAACTCAGGTTCCCCCAGCTACACTTAGTGTTATCATTAGTAAGCAACAGAATACTATGTCCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTTCTTATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACAACCGTTCAATCATAAGTGTACCATCTGTTTTACATCTACAATAACCGGCCCTAAGTTCTTGATGGATCTGGGTAGGAAGGTATAATCACCCTGTTTAACTAGCAGTATGTTGAGAGCAAATTCATGAGGTCCTTTAGTAAGGTCAGTCTCAGTCCAACATTTTGCTAGGTGCTGTCCGATTCCGTTGTAGTCGTCTGTTTAACCTTATGTACGTA ++ +*%.-.+---.4677228=<==?C=@?>D995>JDCF:00/27;?><@91/%$&%+*05/((99?=;A:CC<<,48<82;63.4;268743'1%%'%%%%&(++8:BC?;>897.2+%%)),-7<6->;8&&4.0%%(:<>B7=<><,,0<>A@31.6460/(*$$-%***<>8B@97761132&.1+3/19:58;:34*<841A>ABA>,,=*,8956273;7A?CB=5=97;;D<:B=89.:?;D@>918<5*+(+%3.1+2585ID;>4-6(*&)+=<>BCD@AEFBB?=6%&015-'''&$%%12;<=,,*+,1,=><=<89054*+7;;>34.6*-%63@B<:47567359>:8333/3(*$')-29;38-.-1$))&*0.*(+'*3))3);82?<+,.:2=;@67-947))@@@@BDFLG@A?=8.@9748$$93.*.676A>:;55<??=>A?89=21-/./&$$$$)$%% +@SRR11410539.2020881 2020881/1 +CAGTATGCTTCGTTCAGTTACGCATTATTATTGCTAAGGGTTAAACAGACATTGGCTTCTAAAAACAGAATCGGCGGCACTAACCTTTCATACCCAGACGGTACGACTGTGTTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTGAGTATTTGTACATACTTACCTTTAAGTCACAAAATCCTTTTAGGATTTGGATGATCCTATGTGGCAACGGCAGTACAGACAGCTTACGATGCACCTGAAGGATTTGTGATCCATATTGGCTTCAGTGTAACTGTTATTGCCTGACCAGTAAGTGTGTGTACACAACATCTTAACACAATTAGTGATTGGTTGTCCCCACTAGCTAGATAATCTTTGCTTGGCTTTAGCAGCATCTACAGCAAAGCACACCATGAAAGATAATGGGTTTGAATTGGCGACATTCTGTTGCACATTACCAGCTTGTAGACGTGCTGGCGGCAAGGTGCTGTCGATTCGTTTGTGAAGTCATCTGTTTAAACATATAGCAATACGTAACT ++ +&%'7;99788;:KF51930(()4((,&.0,,0((+&'%'0++/250(*,3%$%''$&+$'56351,('$-')#$'$'(((,.0&+&*-(//(+5423A@242//&*6;87766432462E<CAA<A8:/132:<=:=321)*,./04<<D:3--0=;CCC4?<=1))***(')),+139=@32;=CB44:6>?@<A>=CIF<@DFB>$$(;?855..-44>9?;5<@6643+&)$#$$$'0.)#$&-.,,0(%4-$&*%69833>@GH:@6>77+-&02+1<<9A;<8..49;:;92%.),/*,.@94>=<8@@@=44=C==;7/20>7786899@C?@E;?>E@344=:B:=G:B6>7<><>;;A<4%#$%$&%%%&&'')+0<==884>+988-))()'#$$%%%('%/)'')$&'#'1.-,&'$%&*&+,/5<44@?3$$-))-11354''-2:;;:/,2)++'.3-17/10;>@BD;63%(&,1075+&%'$$*.3%*+''26/+,''$(%*58=00//9<;98)) +@SRR11410539.1500677 1500677/1 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+$#&'%%$()))1;:1,=9<.?>?<=B0/A<='646$$&#+)*/,46'%128<?4#&%,%%('$$+-.7@?JEDD?:28--7'72C?DD7,.89:),3--+&$,%&%-;<>?LF591*),+*./0,9@?1A@?9@?=BBCEA:A/487((<;><;>DC?@959EHGBBB::6.449:89>7<@@;@7<:<=B=>56*)0'...3;=?.%%?;C;A@JH@C?FCFIJAAA;+$9$98:<0+))*)%&&*.,=11228F:86<7=447:I@>B>DD?D7<=>304?1>DBC:;@FF<G5GL@=<>C?@99@<CB=FG<?ABFHIBFF@@D@??====><<53,.*&%%$$$$+7?@=>@=2+*+&&(4@B2?>=2236-55998;AEDD?BJ:6-(6BBLM83>CF@<??::?7933/<55113/62;36-+8)/&%((6;:@>?7;)'26473:5:99-;.-*---)*&$+(#*,///8467.7:@@BAA<2/.%$2)045>BB@<,+' +@SRR11410539.54220 54220/1 +AGCTTTTGCTTTTGATTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAACTTACTCCTACTTGGCGTGTTGTTCTACAGGTTCTAATGTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAGCAACTCATATGAGTGTGACATACCCATTAGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAATTCTCCTCGGCGGGCGTAGTGTAGCTAGATCAATCCATCATTGCCCTGCACTTCATAAATGCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTGTGCCGCACACAAATTTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCCGGCTGAATAAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +&&'('%&#(,,,+)((+/*38;5B>D?GF8>@>?,@DDBFG7>6:6@A>B;@??2+/2369=9E=F<CE>?/@;<=??'&B:=81<=A9=9443&'$35;>>@;BGMB@BDE@DBBJ35ABB5.1+D>??BGEICEC=BC5<2@HDA@44::<543+0$'007;?@B>/4)0=7CEF?=77KIF?B2%*6-../==;9;:==CB<BEAA/%?77A<8?7791/,)&3/./&,(0#$2%))($)*4?>307=26+$$7-4447:8;9;>;=<0/%('&&)%))&'&$"&$$&'/01-482>=>@=6945@?'&=B89/C.61*..5966%>,21###%%'%*-57876//20/./(A9CBA>>0)1)65;BAEHBJF>ADC@B?EI@@D-8.A=-+252789115=?>@??<06;BABBA,/36>45==$.%'*)*$%)()).>B55GEGHB78:66:;<;1-*%)*9>>A>ICB>C@A'ACDA?@=CCEKB'468;>6>44640;?>?>@;5700.,)))9;;=:;910%%' +@SRR11410539.1110144 1110144/1 +ATCATTATTACTTCGTTCGTACGTATTGCTAAGGTTAAGCAGACGACTAATATCGACAACTTTTAGCCTCATAAACTCGGGTTCCCAACTACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATACATGTGTCCTGTTAACTCATCGCGCTTTCTTATGTGTGTAGTACAAATGAAAGACATCGGCATACTCCCTGATTGGGATGTTTGTGAGTGGGTAGCATCTATAGCTAAAAGACGACCGTTCAATCATAAAGTGTACCATCTGCTGATATCATCCACCAAACAACCTGCGGCCCTAAGTTGATGGATCTGGTACACATAATCATCACCCCTGTTTAACAGCATTATTGTGTTGAGCAAATCATGAGGTCCTTTAGTAAGGTCAGTCTCAGTCCAACGCTTAGGTGGCGATTCCGTTTGTAGTCGTCTGGGTAACATAGCAACCAAC ++ +$#%$"#%#%'&+335:,()2,-)%%$%(+178+EB@9;%/,.-1+)&&$$'(1-908++10001636750/39<<78=(,??<384//%+/1204833<EF;987<&&,+4501+A;:772('$--+-''')-57-7%%'6=24%%,;<;87*$,))-?>GA>972%1)++(''(.02;9(;%&7882:(-4.+))52770/,,,'*84**%$$$&'$30%%%-(),(%'.53635470($)&+('%*-232,.67'%((&#%&&'34:691'$%,+-/-.801++$./3-3*+'&$$'#%/044''.%(7;=7;9881&&/&%+1,*(,02*(3+<;?<3055-'&%/-0473$-1'-($(+%)&&&$#'&&)$+3--5++4107//4802,668+<79**2+)(&$$%*&+0&'&-./2898:9.,0-28<72<5&&$$%*-'46/4$%&&&'$ +@SRR11410539.823019 823019/1 +ATGTTGTACTTCGTTCAGTGCATGTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTGACACTGACTTAACAAGCCTTACATTAAGTGGGATTTGTTAAAAATATGACTTCACGAAGAGTTCAACTTCTTTGACCATTATTTTTAAATATTCGGATCGAACATACCACCCAAATTATGCCAACTGTTTGGTTGACAGATATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAAAAATATTTGTTGATGGTCATTCCATTTAGTTTCAGCTGGATACCACTTCAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTACATAGCTCTAGACTTAATTTTAAAGATTACTTGTGTATGCTGCTGACCCTGCCTCTTTGCACTTCGTCAATCTGAGTTTATGGATTTATCACAATAATGAGTCGTCTGTTTAACCTTAGCAATACATGCT ++ +(0112:6**1-23<2)#%1%0(''.+*'&'>DDFG77((1)>>?@6523+3.0-;;9:42.-13:;AF514<5/678</*.09<9/'(()(*&57::-.$4%'9*EFKB;==>042(+%$2351,$%%$,*($#'0'&#(.**0(,)&'$%(*,-++++,)&'&)$)-/,+%#$&&&&'(+,--/0+))$%$##**-,7:;5./%()'&'',&+'(%',;:>?0'95;AB<=>139=7><E2.(,%'6%$$%'.(&%03'.*%#$&-/&&(::?8>@?>=EB<@62<1-:A>44DD?<6:>;9%&($(1.*,/47/)00>0)+%/1+-,%#(*0068()$()'+*:5<:;;+*196324,2/7>=9:@<=.,%#'.-)6?;6145:;<8244765?@.40.-)(((*%,*+*,::3/59;BD=7.((&%$$#%&$#$&$&&%**+.%$$,$&%&)),&*+)$()%&$$$$&*$$08:.(-,6::<67@BAB<9;<<9:3$$$"# +@SRR11410539.1027762 1027762/1 +GATATTACTTCGATTTCAGTTACGTATTGCAGGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCTGGAGATGCCACAACTGCTTATGCTGGCCAGTGTTTTTAACATTTGTCCAAGCTGTCACGGCCAATGTTAATGCACTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTGCGGTGTCTCTATAAAATAGATGTTGACACAGACTTTTGTGAATGAGTTTCGCATATTTGCGTAAACATTTCTCGTGATGATACTATCTGACGATGCTGTTGTGTGTTTTAAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACGGAATGCTGTCGATTCCGTTGTAGTCGTCTGGGCGCAGCAGCCAACGTATCAA ++ +&#&&&*&,,.&'$8==><<GDCA?B@98%#%'('$&?B@@11AACHCDBEBE;><@FH@B>C4<.,-/199(&.&(.9770&/1-477786++/.*(%)#%$%%&--3?HE@A?<99:?<&&;???AC>8/-,*+62<?;>AA=>,,)(,00384;78//<=<+166:<EE7GAE@@?@C@5649:8:446-3:<:?GA>62:+)','446.2-/9<88+6(&&*++%%'&//,,1>:@6==:80C;66(;B95:22A?@,*15=>=FB@61089:187::/4*('4451--+&$$#(+%+(../832?3@C18237778'-.*'(*+&'(,46988686>22.=?D685GAEAC??F76FKB:6@ANKA--,1,&*6/0=HHDCED>:=797&0('$&.;EC99<>;<@E<=+7;<2A89<>ADE?CFBB?<:C=@AIB9C@HJ.&75%+(())//1HJSMABK@7C::=*-***+595:?BDJC5:;FD5/8504::;5,,)$&&$%%$%#$#$'(%%+-$% +@SRR11410539.1372458 1372458/1 +CAGTATTGCTTCGTTAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTAGGTCTTCCTGCCATGTTGAGTGAGAGCGGTGAACCAAGACGCAGTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTTGATCGCGCCCCACTGCGTTCTCCCATTCTGGTTACTGCCAGTTGAATCTGAGGGTCCACCAAACGTAATGCGGGGTGCATTTTCGCTGATTTTGGGGTCCATTATCCAGACATTTTAGTTTGTTCGTTTAGATGAAATCTAAAAACAACACGAACGTCATGATATATAAAAAGTCTTCATAGAACGAACAACGCACTACAAGACTACCAATTTAGGTTCCTGGCAATTAATTGTAAAAGGTAAACGGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +)$,()#$'036@:B=496:H=:1FEG><<'(1EHFJL><457??:<C@9@@3,&(-136C?/@(?@B?756C<>@;'(.3:=ECHC7*)8:44):;=8>BAA=/<5798253/35./.**/)-<@@B63702-.F@DCBD8@DD:59;96B=:E6,1-***798)56:<;<:>?5=@GFADC@BCF?EDCGA>;6:78:>A44>;?BA<AAC;7344442;(.B?CBG@BCG37/.07);;H?/46=223/-1?&&5*+28AC@E1(0>?G?CABCJI>>9>ADELB:;7CF?77934717//5538:76324%$$+23755:<=GCC63821-4)*/7++,./:;<*)>?5=@;0/1GECJGDBB>>79GE>:>>?ABBADC?BF5,(30=?9:$'322;>C<<D:;:?@LE@BD:5@?>B84249DBFA38G>GDFF6=-/8=4:-@@9:))7,C@A>?<AGESFDG=@;B403/<@;9DAAGBB=>AB@<8=A@?;7@=>87%% +@SRR11410539.1731916 1731916/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTGGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTGTATGAAAATGCCTTTTTACCTTTGCTATAGGTATTATTGCTATGTCTGCTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTGGTTTATCTAGTTCGCTAAAAGACGTAATTATGTATGCATCAACTGTGTGTTACCATCACTGCGGCAGCAAGACAATATAATATTAATTACTAGAGTGTGGACAGGTGCGCAATCGAGTTCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTGAAAAGAAAGCT ++ +&*,7<:=?;;6D3;5?FC?AB@FDF54;-,-).=@F?DAD?EI=BC>AC<3,0.986486<1?>EEE@BA6@@A=:9/1+2<KI43301@CB<CC@A>CVGD@88888&+?@A<:;//6@-/87;A9A?<A@C:;FB0:?@<QHSGED@BD>=AB=FBFCBIGMF?98;GEDADKC408::425//3;<@<;;8;))%&(=5>22,/(9778D709341.6968+68;:B@=>A;90*-%-7>=CBC<=;6=<;=AE>EA=@??18<55=>???ECK<..846),;?AD7A<54.((/1/74769?HHGDAB@63*+;AFB@9A<?GF>?=854%,?2.$,+/3+2>@*)29+'+,/()69EJ2%(54'*(*)-/(++.%$4/6;$$++%,'%%+-($(*%-##''-$%.,$4,-'%%#$%')$'#%#%&++,%$&$'',...26=7-4:2%#$$**(&%#'4);5D@J66B:5/);?9<45B989789201//$$,'+&%$$##''')$$ +@SRR11410539.1635244 1635244/1 +GCATTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACGAACGACTACAAACGGAATCGACAGCACCTCGGTATGAGGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGGAAGATTTTCAAGAAAACTGTTCACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTAATGACTTAACAGGAGGGCATACACTCGCTATGTCGATAACAGCTTCTGTGGCCCTGATGGCTGCCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGGTAAGCTTCATGCACTTTGTCCGAACGCAACTGGACTATTGACATAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACCTGGAACGTTCTGAAAAACTATGAATTACGGACACCTTAGGTGCTGTCGATTCCGTTTGTGATTCGTCTGTTTAACCTTAGCAATGCGTAACT ++ +*.*,2371=BB@>Q9A&-6:7?=;;::;6;221CEA?A81*(*1.)*007CEC</2FBB9DH<B5CA=?3>775%%,*'?@B:=A==:9998=>8(($(5+;<>7.C3HL96=GAEEAA?BDCBEA:>;<443///-16>@AB@&&.&.>>/13'&49<=77+,+084-*,+$$%)'+2344/5?.;9::89AF=?>65?>BC<D?C;/.,'$&$%&%(&''56)%0((27;>5:?C?CEB>>:==A64))'*+&*$$$&/3464:DBB986>8;5.';=9;??06(=;:4766IJ><G<>B6>*,//15<G<;@.091+-%67=?=>ADB=@B@8$$86/0&%0,-;??@($@>A@E;/--,.'97A8ABCDDAB@F>;9;;=<DDCD<13421>?6>/6+56/...1241$($6:7@DAHBA8<773,)25907---+%/,0-*9@?>9=1@9<:B>>ABBB@?B8=9;1,*$&%**2>6;IID@?,/+,25878%%;<8531( +@SRR11410539.2351902 2351902/1 +CAGTGACCCGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAAAACTTACAAAGATTATCTAGCTAGTGGGGACAACCAATCACTAATTGTGTTAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCCATAGATCATCCAAATCTAAGTTTTGTGACTTAAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTACACTTAAAAACACAGTCTGTACCGTCTACGGTATGTGGGAGAAGGTTAAGATTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACACTTAGCAACTCTTAA ++ +.*0534421&/1)12=>;67A?.:779?C<A@989?7>?BD?<884.--,'-2331(,1888=A0-<?B@?=?12A5<36AB8,&=)@==>>==;96.:66=<<581003CB>?B@E@A?:=>::@EABD?A84:DEG=B9:88==II32ECAE@?A:@AA@:<=6.-'78:7;78),8?A94B20@??25;36?BG;>>A?>>;>:>6797@@FDF4?,;E=EF8FA>F(@9B:103685::;7;=A8:A;>66>?=56@?</=6<5:)1D?@BA>@:;>.'69.8B669;<4',237@CE<6,&8,<>-8:430+8<>8859((,,*53<147=9''?550)9&%4>27JD?DDD;<9ACF-',-*'(*=<3302:BBBBBBA@=@:7'(+'$%'001<EBIJ=;6?;;:;?A=>7778HI=C?;=<8<57.-.878=88-,C8@FB>@=99+6(/;&H46*+.'&,<>BA?BA<??2A=GBG:?AA<;:;>A==<>6.,.%##%)%''&#'##$## +@SRR11410539.1038477 1038477/1 +CGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAAATCGACAGCACCTTCAGGTGATGGCACAACAAGTCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGCTGGATGCTGTCGATTCCGTTTGGCAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'#$$558/6DA3):8=A:?HGDEBBF>>-FFBAD@=./;6@>>=<:;:(,',9>@>@>E?EE?@B>9;88@769:816>22://+&?+EB?9A677>?FCCDA=A=?EFD<=:=>/1<@3..;@D;AIFC?9;;<8<?@8/7/-0:57A;=>F@JMD:7666;151CBA8<<;;=4552A1E@B??=4EDHBB:>CA@/>::@/@&&&(.--4+?;;C>86:7;>@BA:>D@A@E?<A=<?>9BC?DAC?;;CDA:<;?AEBAAB=ABAJBA:999%)/&+:>@;<A@@2@4</;:DIG=BC=I>BLICA-.E683@FI@II?A''46.79<@GGHF5>;;;;9,577CADH?>BDE@@>AE=@C=21(-7DC:>;HK<;45=6<<:?<==><<;4.<;@::B=?@@<=:59??<>?;6:<07$($$$%%$7643<?E:>D@:=;FA>=@D@>C??41<=>BDAB=030-'$$%5:0/&&$&*-$64;5:9BECHEBD<D@>-&%%&8@>>AA?@?=''=B;=C??>>)6=96'1# +@SRR11410539.1390629 1390629/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGACAACTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAACCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCGTAGTGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAGCCGATGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +%*+24.;>?CCH=>4AED@@?B>>>74/2(BQDAC2=>>@=>994553437/0.7<<A@**2;:244=8,89:70;:ABLCF640--);)')%$&%/,&,))&2567077:%60=6;>H4)1/&118?:??9116:/53:;78EF>BC@LNFCAF><50(69:=EHDMGDADE@?ADD=??2M>%1*&<FAJD<>>53&'$$%(&(1%%>?A@@:<DDFE?:88-26<>?0+(,;:)'*9+,3;>AA5@B@<69@E;31:>89AB:<F<80D==02>@CB>?:986-&&%&*'$$$%%(,$)7<?BA??9<07:81232/5:=56;7:<;=B=<9?877;>9+%''+0.&$''-//-,*06,-3?H<===?BDCB>++-2/-,5:9??8J.0A1<>;99>443/-57<:<;=33:?CBEB8:>AB9<8@=@A6,*<=;377=C@34(.../056(*:;7''.(,&'.5===@61D@?AC?A?JDK@@>@:@-):CB@BFEHDA@;633=?CJDE<52% +@SRR11410539.921407 921407/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACCGAACGACTACAAGCAGATCGACAGCACCTGGTGTTGTTGGAGAAAGAGTTGAAAGATATGGCGACAGCAACCTGTAGAAATACTCCAAAGAAAGAATCAACATCAATATTATTAGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTTCTGCTTCCTAAGATGCTTTTGTACAAACTGTGAGAAAGGTTTGGATTATAAAGCATTCAAACAAAATTGTTGAATCCTGGTAATTTTAAATTCTGAAAGGAGAAGAAGCTAAAAGGTGCGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTGTTATTTGCATCGAGGCTGCTCGTGTTGCTGATCAAATTTTCTCCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAAGGCCCTTCTGGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTCAACATAGCAATACGTAACTT ++ +$$+-59655379B*0(28>A117578/0945.@9:784&,**.-0//--013&.))//08;+$..,--1799:041/0-./(64,$$$%&#$%%*&'')$$$%,(.&0)*227.*%%1?>;:58'0/-+&0*&'+&$6$'+%%$%%*)-+%.%&$*)&()/6@CD>@=:;924?*8:<<=8:;?AA6:<DB75573=?>A>>87+-.10,-+$%&%&&&/0//*%#'+++&0-1..&))(**&7:475F:4;>@A5<CC6:BC>;<3645:9<?99?3350.1>A@@F@8+($&)&&&(-'+10/+0)$)*((12.$+980*352:GGI@<>@ABA04,-2.23467400124**2(*%&#&%+,/12;0.-'$&'00++--,/-(+(&')&''%''-/-+2+%*&%)**,*&++(:3@BD>>;>>=8:094;8DCDEK816..1+%)3-,##'''&(*>;=BA>AC?KC?@9?@D=<?89.(&'&$&&&(**1).%==>91/-'%12&&& +@SRR11410539.1934526 1934526/1 +GTTATTACTTCGATTTCAGTTACATTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGTGTACTCTATAAGTTTGATGGTGTGTAACAGATGTTCTTTGCACTAAAAACTCTAGGTAAGAAATGCAAAAGTCACCATTAGTTGTATTACAGTAATATCGTGCCAGGCAAACCAGGCACGACAAAACCCTTCTCTTTATGACTGCAGCAATCAATGGGCAAGCTTTGTCTGTTATATGTACACCACGCTGGCTAAACCATGTCCAAAATCAGCATGTTTGTTAGCCAAAACAAGTATCTGTAGATGCTATGTCACGAGTGACACCACCATCAATAACCTTGTATCCTATATGATTTCACTTGAAAAGTCAGTATGTTTAGACATGACATGAACAGGTGTTATTAAATAGAAAATAGCAGCAACAAAGGAACACAAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCAATAACC ++ +&%%'%*6888+0+?E(<8;:>@=**.95:ACH:;9DLIDG@=449;=9?@6;<?9>8:<:===B<@7DCDC>>9E>:8?9:A<CAC><:8B?<==999-*))+41:322/**,7%+115:<DFD?3?.D;AA:<2A9743;12''(<@7<:211(/.0%&$$'%&%%&(($+51+1.//-('<348@8479:9876757+.0*$$6;>@A?1689;<A=/(:BE?5A79:2443452<ACD*$-%#(-0,,%#''+9;<D@=;>45538;.89:50&&?:<>1+14*.,0/=?G>C::1,21409B=>>H)&+::>>>ED:ABG=<5=4.%$*000:1AA@=?6-A775$%/014>AE78;K@*:BEBADFFF?BC=AO@8;:@59EF??D<>==?<;>@@@--5560/33E?LOKNJHIG>76;2@E?721<('8>776(*C?@B97,-+;8;3?9><;929ACD@B9FEI93C7:7.9<::=@5((&'&(6''''))2%&&'(%% +@SRR11410539.1424426 1424426/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAAACAACACCTAATTTGGAAGAAGCTGCTCGGTATGAGATCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAACACCTGAAGAACATTTTGTGAAACCATCTCACTTGCTGGTTCCTATAAAAGATTGGTCCTATTCTGGTTAATCTACACAACTAGGTATAAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCTACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGGTAACATTAACCTCCACACGCAAAGTTGTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTGGCCTTAACTAATAAC ++ +&($&&*'(/012<9,'87>DDEGGEE10C34/9<DGH=96;69(('),,./%'$&((%.$%.2?A@DC@IE/0AE'((4??;;2=678<-/19::A-;CB6ACA=>A?CDF>9A@==<=?==FBIF@E?>CB@876;?BDD??7<68==<=?8=1:=;@A71:;<<GD5D+8(),7>;?<>>>5(AFC>@BEE$698AA;::76=?75886<=9:AA/0ABAFK5%,--1%'''*(;@<70%)04=@=B<0,//)*:6C<=8>>%(5EEI>D<)+;6&,65=//3:>>@6C741,,,017?</%-99978),===>3410,4;:<<9;/6-+:97?DGG@?>?CAFB;A=>FB:;>A=B55C:>9@?E=@:87.///3858=7.))%.3)*4600;>C:A01,)6-0/$%25?:;;2367::?==<3&524/0795-24@<>?;7C>:FF:;0::IA:;9796<A;::4$$#$#'(($$%%%&&# +@SRR11410539.603810 603810/1 +CATTAATACTTCGGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCATTGGCGCTGGACTGTGCCTGATTTTATTAAGCCAGATATATTACGCGTATACGCCAACAGGTGAACGCTTGCATAAGCTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTGCTGACATTAGATAATCAAGTCTCAATGGTAGCTGGTATGATTTCGGTGATTTCATACAAGCCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTCATTGTTAATGCCTATATTAACTGACCAGGGCTTCTTTGCAGTCATGTTGTACTGACAACAAAGCCTTGATATAAATGAGGTTGTTAAAATATGACTTCCTGGAAGAGAGGTTAAAACTCTTTGACCGTTGATACCCTAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTTAGCAATACGTAACT ++ +$'#%$$*'#)*'%)8.<)1/5<B<DEFF>==))2AB9'('%%*%(.+-+)*0225485950$$$%''#$%$*2,,("#$%&+*147*%$%$%&/5//:B=87=<79=<AC;66@331&%%&(7<:92,(##%'*&&./&+,28,/7876-*1%.*07:69>567<8:2327,+-&'.12.)/07DC><>==>;552'95A@B?F<43;88:57%&&224><=B36+=%11<AABBCAJF1*,3;>?BADE:74445'*)/<;;;9B<474=453;=8-/15?@98?5DHCCD;11+/48:7798;;:?>5(&&,0))%),+(--=:;111'').)'(&0-10045++114845-.6;<;2563.+*+)(%&#%&$&,(-996=@?;5357-$/0%'%$%4600111?:;?@C8;=976.2(*.065-,1021+&#$('1756:B?@>9:<CBD=5<41-''&&(1:5-.$&#$.'('+)&&;@?62(+ 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+.$&%'&+59<@=GA*,%/601:C>BE<;5/0;EMKGKE.0+*%%%%>B9BDBHL=A373;8=BHBBEGF@@G>AB>856==?@>>78FGCHFCHFFKCB8578536,,+3..-5/@=4449;A@@:<9>?B>;FIG:8:34.''')*%*,22<965/(3:6337='*16GHDC>0B<>9=9CAC6=9:?8//A))+EC/=CCFBB<BB@BIJ93.+$*&+%1368?HD?6,B0=;6>:)&#&+1*78:5:D,?/*('.4560+B8<9;;==92&A,>ACE<FQN?=74:7<>CBAIABD5.C77@@:726$&$$(##%#$(*),44,?99:;H<()%$*&%%%(+)(8,(/:<AAEECDGA@<?<>>@;;66@5)--<FHA6@6$$($76-.3/4<<:7898??5>8D>9:CEGC=ABA+C:<=@:85)-,1<=996=6>DB0+&%/');0//.156*0,50=;:::67().-17?=>&'&%%&*7)<=;;80,$'%%%((&$&+,+$ +@SRR11410539.1221028 1221028/1 +CGGTAATACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAGAATCCGGCAACACCTTGGAAAAGAAAGGTAAGAACAAGTCCTGAGTTGAATGTAAACTGAGGATCTAACTTTGTCGGGGTAATAAACACCACGTGTGAAAAGAATTATTGCTATACGGGGAGTGGCAGTGAGTTCTGGTTGTAAGATTAACACTGACTAGAGACTAGTGGCAATAAAACAAGAAAAACAAACATTGTTCGTTTAGTTTATTGTTTCAGAACATCACTAGAAACTAACAACTCTGTTGTTTTCTCTAATTATAAGTCTACCTTTACTAAGAAGAGATAAAATCATATCATTGATTTGACCTTCTTTTAAAAGACATAACAGCAGTACCCCTTAATTTAAGGGAAATTTACTCATGTCAAATAAAGAATAGGAAGACAACTGAATTGGATTTGTAGGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +2$&*%&)*/3:9:@7)*-9;<==GHFH@??+(236:67012389CA<?>?<=)2)-0/2:$$5$&8/0;>CCEE?A;@F'1C>41>;)).1)1+,.006989?D>;:?>;3)(%$',*<@=33((+-69C60;./+9136757;9?@A=A<A?;77;9%))*')%%'#$$%&&*%*)('(1$$%('794DFD):69695,00'==>AA./#'DGB09*(2)8887A<BE=?<ACE>5237;339.+.00>??@@A@?9C?1./%+,'*+%$&%'))*>@A>CB==F@AD=599;;;<?DBC=CC=E?C?7/C*=?>=7635055+87=?@@0<:,,1((,*::<@CBB:A:BA@@77=BCIHEDA;?@E6OIN>DF-%,2123559673;8;9BAD;8BCECI@860(',478=C76;6>==9>@A=;BH220:9=;@*6DAB83.:<997<8;4:AF;.5+.8B:AB=8=A==>AC?HDL?9149949=:>?=122&)&'2%056=??553,& +@SRR11410539.811643 811643/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACCGATGGAAATCGACAGCACCTATTCTACACTCCAGGGGACCACCTGGTACTGGTAAGTCATTTATATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTTGCTCTCATGCCGCTGTTGATGCGCTATGTGAGGAAAGGCGATAAAATGTTGCCTATAGATAAATGTGGTAAATTATACCTGCGATATGCTCGTGTAGAGATGTTTTTGATAAATTCAAGTGAATTCAACATTAGGAACGAGGTATGTCTTTTTTGTGCACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGTGGCCACAAATTATGATTGAGGTGTTGTCAGTAGCGGATTACGTGCTAAGCACTAATATTGTACATTGGCGACCCTGCTCAATTACAATTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCGCCAGCGGCTACGT ++ +&(*00-46>><D52.00756:<56;;?@<;39JB?B@;::??:53470,)$$%&))(-0>>>9A@8B;:=<<;/24-$4,=993441./-.%+8;>FJI;<51-&8@8330&*/)1,6>4877?<)5(,'''/;=77?EDBBH==?A,8&7%(#($&$%,--((,54:<8:BDF88CA9:94840%#%%$$+04(533$+(-'(9=A@D%%ED<==?<>7:;6*-88=<168+*%*005.++;((%#)'$'()/(7+(&.%*'96?><;9CGF@>=KDD622=862GJF@@B442&-,%-,*'%1=72445<<CA=<.%$$%'32.01-'$,,-,%.)47:@>:551/&%$$C>?73@?BC88ABC@?+8%%-.1)789%%%&$$$,124@AE=12(?<7+3:<>=>7/1)'(&&'%*)55&%$&'').003**+'+''&'$+6>74<8=<<DDE@A8=0;%%%($&##%'-<:56956<<),,57=20<4;?9:B9>GF<54*+%&&*$%#$%)12&$ +@SRR11410539.1713855 1713855/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAAACGGAATCGACAGCACCTTGTTAAGCGTATTTGACTGGACTAGTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTCTGGCCTCAAGCTGATGTAGAATGATGGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGGTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGATTTGTGATGGTGGCAGTTTGTAGGTGCTGTCGATTCCGGTTTGTAGTCGTCTACTAACCTTAGCAATAC ++ +$$237:6>AC?AQ591<FFHCBIKEF?AD886DKF<=/4;6DCFC=@?=;>==7689B?<?D@@A>CFD?GBFD89<*%/'),?A@>B>A,(,'$5=>D?B66:A9=9:9=3372>@//59<FF4:>>DAAAFF>G<=A4+5&--%*@D+9%%39&%A>E7>GI@EA89%>@B=EEEG@E:-67>6C=<>GC,6474:@?>'%&8=.AEF39?BBK90=GIA=?9002+,$'#+*)+-*=<=C?DHFBA.:*0,-*'%'*79:3.8=?DCDE;>@?A8>4*3+CB@B@A95++1=>DFFH;@5:&35:8B4C8EAA=DFCBC=>9'>ED>4A5>CDCED@?B=D?>A>34>;238*:61*@>>345:<DBFCGAC>C?E==:5@A;<BC?>A58/3?A@CE>FEC951/.(.9BDBCB=?66AHBBD=9B?DB5555...499>?B()%6888>A>I=@A984+:.0G<<>A:=66608;86DC7@=AJF<599:8=655,%'*55?AE3'68013,( +@SRR11410539.1547229 1547229/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGGCGACTGGAATCGACAGCACCGCCTTAAGGATCAGTGCCGGCTCTGATCGCCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCACCGCGCTCCTTTATTACCGTTCTTACGAAGAAGAACCTTGCGGTAAGCCACTGTTTCGCCCACATGAGGGACAAAGGACACCAAGTGTCTCACCACTACGACCGTACTGAATGCCTTCGAGTTCTTGCACCAGCTCAACCATAGCGCTGATATGAGGTTACGGTTCGAGCATCCGGAGCGTTTGATGAACACATAGGGCTGTTCAAGTTGAGGCAAAACGCCTTTTTCAACTTCTACTAATTGCCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCACAGGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAAACAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%**+'+'47;8:@91,8:@B7414=AA;<<=-BJF<>,2-4760/)&$&&(68AA*&<:>3-&66>@@<(D1++'+8--,#%&')#&&:??@A666.7;9<?>D<4ED580)-733:116?A@?73+''&#%(**))7@B9A;A;?583$7:FIDII65:980))-B>=9EG@A=@?=B577=77),-23*++(25751/0151/?>&?BC=00?+,,?;5;EAGCCE<<;44('+34<@BEEE15<<=6-/(:60,$$'()+071?>1-.==4,0$&/*0.*%$-/&$=(,&<*.:;:88AC@'':'(&'8=@@?0/887:9,2203439;59EB=)+*96:+0469::15>?@>?CA-?()226A7B<7+)%(/45@>@IE@./1(5::<>977C@=;4B5559679887:4;)><0)1>;>C0A7999C?+8::77<7778=51=11313.0,-%4756/0-=21=5-<755617=GBD;>AB;=;<AACAB?EJBC@@?8643017<@B/'* +@SRR11410539.781248 781248/1 +CATTATTACTTCGTTCAGTTACGTATTACTAAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAGCCCCCTATTAAACATGCACGTGTTTGAAAAACATTAGAACCTGTAGAATAAACACGCAGAGTAGGAGTAAGTTGATCTGCATGAATAGCAACAGGGACTGTGCAGTTAACACCCTGATAAAGAACAGCAACCTGGTTGAAGTATTTGTTCCTGGTGTTATAACACTGACACCACCAAAGAACATGGTGTAATGTCAAAGTCTCAAGTGTCTGTGGATCTGGACCCAGCATCAGTAGTGTCAACAATGTCTCTGCCAAATTGTTGGAAAGGCAGAAACTTTTTGTTAGACTCAGTAAGAACACCTGTGCCTGTTAAACCATTGAAGTTGAAATTGACACATTTGTTTTTAACCAAATTAAGTAGACTTTTTAGGTCCACAAGTTGCTGGAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTTAACCTTAGCAATACGTAACA ++ +(%$&'(05:@E@>K1?:=FD?2*75;8/5;%&*&08;9:234.=@BEG@HI?B9?:?::8?658C?<>90/+-'%%%8;36AB>2+'),+32CCDJABDQBC=?445=5=:A@G?8=5:>A@A552/**(''&5502(0446;7:=<9<C+=>EHHG9;67..9=@>?507)@7=:;DBDC>CDAK@CBECF=2<3.5'('(<<D<>95*)24EBCBB(11)*5687=68-*&&*.(7:2+01289689+'/*'(5.0;;=;?@<5=>>)(6;<5$&%9:=@?;>BD>0/),0*&654*5733)+683@6:=,,,2503)1>71,))*1>>G>@A23*+%*=9--@<3@CCE>E8AA=?<C0<6:=45-=B@D;:@/FBAAHE=<:D9CDAGA=:;>=?>9@?;>ID>9?AEDH@>?PEB,-)8&&/.1&''1173?CA?>-%82++//002->E<<>150)+><>D>:@=<J/465?@7?B>785:B;:ABC99:462/*'('')-*%'((+' +@SRR11410539.378820 378820/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTACCGGTTGTAGGGAAGCATTGCTACTTAAACCAGCAAATGGTTTAAAAATTACGAAGAGGTTGGCCACACAGATCTAATATGTTGCTTATGTGAACAATTCTAGTCTTACTATTAAGAAACTGTGAATTATCTATAGGTATTGGGATTTAAAACCCTTGCTACTCATGGTTTAGCACAACGGTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAGCTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGGCATAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTATAAGAGTACAAATTCTATAATTAAAGAAACATCTATGCCGACTACTATAGCAAAAGAATACTGTAGGTGCTGTCGATTCCGTTTTATGAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +*&))1329:;69L==5:DIHAAIHDE@?988''3;=DFD1212>EJAAE:;<,4$'$.53&%&48=?>=90++%$/#'05/%*(''&#/8,,/)252..5BD;5)%%&*+)&''/236676688+(011--2987*))*34BA@?,&>+)*),%%*/89?@;740&&035615@A=?9=?A<?GBD?891///.*%('$$$+(&)'$$#&&2-05%*8%-..&(-*//*))$/9B@AAC@46:;/%+%%%%&)$%-&+895B<<<A448799FA98=E1.C>>CH;=@<>9943$&+&=IHHED889A@BAGK9CA5;;831*;?9?@;<1*&4747-%245<?BHFICE5BA>HG@?8/.,%,%(%'8<A@B;<9HCFFH?JE6:89;HBDJCCFB:3336,)&$##$'(*()$%*+'<=<BA>D<8-'''*$'EGA.355=B?@>>%%A@?G==7@HD3;-.CD0&(00,++4329.3@AA<4.<=@BE01+.4:+%%$$(8;<6@:7@>500'($&035<=ACJEIB5(+ +@SRR11410539.2197758 2197758/1 +CCGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAGACGGAATCGACAGCACCTTGGTCAGAATAGTGCCATGGAGTGGCACGTTGAGAAAAATGTTAGTTTCTGGATTGAATGACCACATGGAACATACGCGCAAACAGTCTGAAAGAAGTAATGAAGCTGAGTACATCAAACCTACAGACAAGCCATTGCGATAGCAATTCCACCAGTGATCAATTTATTCTGTAAACAGCAGCAAGCACAAAACAAGCTAAAGTTACTGGCCATAACAGCCAAAGGAAAATTAGCAATTATATACAAAAACCTATTCCCTGTTGGCATAGGCAAATTGTAGAAGACAAATCATGTAGAATAGGAAACCTATTACTAGGTTCCATTGTTCAAGGAGCTTTTAAACTCTTCAGCGGTAATAGTACCGTTGGAATCTGCCATGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGGCTT ++ +3+)++22.4245.)3:@@>;7634326%&1986/1*2769BAE><A?::@B04372>AA652?<<96:-/69D47G@E@IDFD<:675:@?A91@:D;9/&..,)8++:2+6EBC=:47++195:*:<@<0D3@AC>84&'096>3@EGB0+-&=)./=2%((*(6:7013-326+(*'+3/9,0$346,)/(60-/.><..10;:A.@()-.-0'('),,-<8,'09;:<?<66:(13(-//,-696:120479;;@=?=??A@<>.158*,:12:;BA@=?=@3<JH1'7*2798-9$%>>;A<9611=78/77526F?@?BFC@DC<<<>>;@<A48;;A68A2A48A@=>>:??;<'2&%A:9:&360412//243.2';8:<C@LH8?@:*+.*)'134:556(3478448*6$%*/0-5%0*;;9=<?BB>:=?8<>:7355=8;5;>95686?D??9?9F8@>>=@52@8;??-3)$$$.0/0//*&&### +@SRR11410539.1225701 1225701/1 +CAGTATGCGCTTCGTTCCCAGTTACGTATTGCTAAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACGAGTTCGCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTGGCATCTTAAAGATGGCACTTGGCCCAAAGCGGTAAATTTGAAAAAGGCGTTTGCCTCAACTTGAACAGCCTATGTGTTCATCAGCAATTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCCGAAGAGGCATTCCAGTACGGTCGTAGTGGTGAGACGCGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTTAACTTCGTAAGAACGGTAATAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCCTTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACAATAGC ++ +,''.'%$##+9<>=E7&*'$)76,.(;;;84.%#$/)-8;8@11;+9697-146*6',24:;<;9C<<8>=AD@??=@/$&&&,3*9%('.*)(&,->:62625/D@A**0?9<?>EAC=EBE@@<74'%.3327>9=65256202++*()5<A=4566+;@:;<,$$%&%#$$#&''('(0),)*..0...*%*(3354/%((-;%&%%%89?9:8A?25**1,*)'&'*%%%('),637:;65;785=>BFEAECD8:=<@:=>@=@?8302%-*((+*''42:52;/@BB'8-,')06DHDG1&805=9A8D:=;;;B>AC8A45,(%%14;::<?;C=<>D@@>;>;2:==:((2<@A?=@>HDGCNE20078:;+DI?<<;*566;==99=;?CIF%0;''')*(-(;>===?>@?>56/BA@5C+3DGHDF@7@8;>42@G9:<AGDCGB:BD=>1032=<<;5:81129700;--200.;CDBC=8ABBG@BD<HELFBB@:<327($/-*+&)%%'*')))&&###$&& +@SRR11410539.312034 312034/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCCAGGACGACTACAAACGAATCGACAGCACCTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCCATTTGTATTTCTAAACATTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTTGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTAACCAGCAATACGTAAT ++ +%#$$1:8>DEA>IH05+(/23-67%+5=;88)HG@><.7?8:3+.1.4,&(353++*982>E;E4<=CB@C>DEBBGBB:5:3//0,'99@E@@BFF@:6//-..88:5.++#&$-:;>=?A>@DD+0776@A@@@CDG@AC=><CAIE5/6=A<;;ACGAB=@,,@7=;F<>;8-'(-+79<8679.>=''+>?ACEEIB>:<A@?@7<@0=>H>;:>268DA>@?@C?=>B@@@27CCEFG9;=?B>?@@A?6>9;=>@B;IA9=B@A:<78=B66@=>;@=344=D@,,<9@DKBHF?='7&')%70406'75:79GE?FB93CECCBC@F<;IQ@2?CB<>0AABD;=IFB>F?3328;<GE?=@?67,1,.331188=>B:'DJGH88E8?5(&;?BEMK;>C=?9;882(4<F?CFA;A6==@<BF>ADEB?H@?=%%($$8ABCEC<BDFLG?2%8;L@AG@;3*;@>BCB@86*$$%#$001;=?@D<9-1& +@SRR11410539.853615 853615/1 +GTTGTACTTCGTTCAGTTACGGCCTTATTGCTAAACAGACGACCTACAAAAACGGAATCGACAGCACCTAGCCTCATAAAACTCAGGTTCCCAATACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTCATATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACGAACCGTTCAATCATAAGTGTACCTGCATCTGTTTTTACGATATCATCTACAAAACAGCCGGCCCCTAAGTTCTTGATGGATCTGGGTAAGGAAGGTACACATAATCATCACCCTGTTTAACTAGCATTGTATGTTGAGGCAAAATTCATGAGGTCCTTTAGTAGGTCAGTCTCAGTCCAACATTTTGCTAGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGTA ++ +$$$',+11102361-<94+3'(%$'.,,1652:>)($)$--/(%(/3575938264>;9>E<8A8>BB/)<78'>*6>@ED@+ACDIMF56BFIEA?@ID=<77=:>@B=C?D?45=B@;=CCAB5:415//69;>=>?@BG?9:;9&&)*)$+36580>;;F<<1B19;<9*#)99<EAAFA8-.7:7BFHE5>@I324;(%8%%%5314@9=?<88=7CE>FGHHC>;50/%@94CBFD;DCCACC<8EE@893)02:=547<>>FACCF>@2:67/=:832/'(38?BC>DADB;7688BD>>?:=0)268@D<<::403-*((+'(3'0BJHFCA<=E7<B@:@9&'.@7@CA;;3DC5;DE=D989=BAAG<JHF@BB>C89<CEC?C<?ABF(+-5567?9>>2311/?4599=96+(7+A9A;>:;6A<>,,A9:ABKJUMBA>=:%7B;<<40><:8<68<@=JBDD@:?<>@=A>>812/2/1)23/*&%$(%$"% +@SRR11410539.152875 152875/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAATGGAATCGACAGCACCTACTTTTGAAGAAGCTGCGCTGTGCACCAACTTTTTGTTAAATAAAGAAATGTATCTAAGGATTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAATTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAGAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGGTGCTGTCATTCCGTTTGTAGTCGTCTCTATTTAACATGGCAATACATGTTT ++ +)/0696<=>?@M972?IEB@8987;-:7//'7-7DHJ8D9C@BB><55//+&$''3>@AHECIJBFDB>8=BG;532/32'<@8B88<.D;:425$$&./;<@BHEACE>EH:+11@<>CD?C=??%?+EKEDDBG?B9;@(><@@9971&$.<F@<<;:CHDDB:=,5)(8;9:=C<CD@AAA@@850;<>>==::=GHFEK=&&&)7:78@@DCBDFA?>458?F<=<>8D5A<?=4:@;;DD>BEE?@=;>A>55./,.054$:AABFH/(,,?7:712A9@==CGE>BBCEGH<DIGB9EC88DB=<865;=0;;2:3A:<;<<:@E<??B@:IE==B<2E=:;DB@7=/:4>DGE=?EDF@76=73@402+9))79:<402>J208829<>H@BC7F?@DOL>;C88=;1256<=@99<DGIFB8>>?EEKFTIEBDHD9@>DAHAA9;@=88?><6>C@>B@<?9::8:>GEKA<8778404-'()00.00.(/&.6661/+/&$&&% +@SRR11410539.2484305 2484305/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGGAATCGACAGCACCTACAGTATTCTTTGCTATAGTAGTCGGCATAGATGCTTTAATTCTAGAATTTGTACTTCTAGTAAAAGTACACAATTGTAGCAATAAAATAAAGAAATAAGGCATATAATTAGTACAAACACAGTTTAAACACCGTGTAACTATGTTAGTAGTTGTACTAACAACTTTGTTAAGAAAAGGAAACAGCATAATTAGCTATAGTATCCCAAGGGACACTATTAGCAGCTAAACCATGGTAGCAAGGGTTTTCAAACCTAATACTCTAGATAATTCATTAGGTTTCTTAATAGTAGGGCTAGAATTGTCTACATAAGCAGCCATTAGATCTGTGTAGCCCAACCTCTTCTCTGTAATTTTTAAACTATTATTTGCTGGTTTAAGTATAATGTCTCCTACAACTTCGGTAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +*++(*)57::=D8/*6+/<63443617812/?HEFJAAB?F;=94/7:?A=*$7;<;..<=87))<>=06756DAB>76@E?CG,=BGDGA;B6>B;859:53/0@8ADCA?1<,1>BEL??>9;=>@@99FGH@;EA>H;21(+196?>651)+),.=;2+11B9<=<=?BBFB>?828-?>>=@?;8(&<78;?NF@76/6=9:1249743/-/'**4,08<;8-.+*%%$%'589;22(35/*&&)'&*0-19?EFII@CCB=ACCEE::>845+;?54951)$$)(115=0CE;<@?:$*281512:%;CCO6?110=&:DHG?=<@:><BCADAC=%%54==IEC?DC>B?87)6&)%3,8&.9@ED=>===<9-.56:205%%+)3..71054)%%&''...47AD8.%,6<@CDDEQOE@B0<1EFB8C>QEJI>@LK=23(,.1:>?B<=C8?B;:=:))D8>=;129A63?BDD:48:...699DCE=BED;>?>B=ACDD???>;<=<=BBADD><98$$& +@SRR11410539.378851 378851/1 +CGTGTACTTCGTTCAGTTACGTATTGCTAAGGGTTAGAACTGACTACAAGCGGAATCGACATGCACCTGTTGAACCTTTCTACAAGCCGCATTAAATCTTCCGAAAGTTCATCACCAATTATGGGGATATTCAATAGTCAGTCAACGCGCTTAACAAACGCTGGCTGGACAGCTAGACACCTAGTCATGATTGCATCACAACTAGCTACATGTGCATTACCTGTGGACTTGACAATACAGATCATGGTTGCTTTGTAGTTATAAAGCCATTGTTTGAACATCAATCATAAACGGATTATAGACGTAATCAATCCAATAGAATGATGCCCGCAGGCATAAGTTAATCTGAAGCAGTGGAAAGCATCAATGGCGTCTATCACACCAGACAACAAGGTGCGCTCCAGGTCCTATTTTCACAAAATACTTCACCAGATGTCAACTCAAAGCTTATGTACCAAGGTGCTGTCAGTTCAGTTTGTATGGTCGTCTGTTCCAGCTATGTTCGCTACGCTAACATA ++ +&%($$$"#$&)()($/.-%1./001('-'('+7>6---,),75?>9;79%;*,,0*2-,+&#$(+00-+)&%%&(,(..2)&$25,33%)$##'+*)-$(#&#%%%,9<:85.',,')'*((&*794($$%'%%'&.&6-9<?$$(%$$##$&&&#%%3$%,%&$,8;<849>=@C@?7;:9=>;:6@F??G=@>=@A==<<<D;=A>4<>@CCD776)((*+&9;=:NJF@@:<=0//-(//43+/EE3../2,'%(*+'-01,$,%+$*(15<??A4=<A<<@@0479>?:><368565.-/--,.814,,?=>9264?6-/3-1/#$%%&1:01021,2-,)*%&-2,-,):*+**'&,&$$%%($&)-44+)-6.2&#&01:9((0&&612-(/8=%41-79;=>5GGL</--8:<B::112*%%%*.1)*096;>>=990$$$%%$#$####$)$/%%*%$&%$%&&%%&''$$'.%)+*(&&&%&'#$$#"&#$##$%#"%#%%$---.'($ +@SRR11410539.1346832 1346832/1 +CGGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTCAGGTGATGGCACAACAAAGTCTATTTCTGAACATGACTACCAGATTGGTTATACTGAAAATAGGAATCTGGGTAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGGATTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACATGTACTCATTCGTTTCGGAAAGACAAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCATAGGTGCTGTCGATTCCGTTTGTAAGTCGTCTGTTTTGAAAACATAGCAATACGTAACT ++ +5$(%,--;==9;M.5/<@@=B?D??D@AC66-BCCDH6?:9=A9:7676FG@>;=FD?==?;97B@@BA/0*9=@8=B?@;99**4231+&8,CGE06,33=><AEEAGH>AJEA:1))BDB<;>>@@B:3+*(&(*03(-4CB?:.51,9;DA@=;4++,7<=<6CA<40125868/0.4&4/423@=7@4@DDC>8=?BDB2>999;776?@@>A=998956@><B;;??=@<;<;???B<HE@5<@:BAEGA:@DHBGDCCB?/<(../.==010<@;;<11A:6/47B5:=C<>?ECHL;AFJBE''?33/77-6>7:=AE::/'4877GFIJF49()(-75878=<;BA>?>B?A@DCCBFGGLA?;GE>@?FI88/040)5894ACIHA@>AFA876(&>>CC?=D9217@<HD?A-/)-&+46$&91+2A@F>AA;886>;;31;<=51<?@?B?EB@?GF=:ACC9''%&.1%$3%7:@8888<8AA<+(%(22>16=?@>?@1)))($%%1233AB;=EBB91#( +@SRR11410539.1236160 1236160/1 +CATTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACGGAGCGACTACAAACGGAATCGACAGCACCTACTACCGAAGTTGTAGGAGACGATAAACCAGCAAATAATAGTTTAAAAATTACAGAGAGAGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGGATACTATAGCTAATTATGCTAAGCCTTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTTGTAGGTGCTGTCGATTCCGTTTGTGATCGTCTGTTTAACCTTAGCAATACGTAACT ++ +(%$&(%%-./36=:=35=@.BDA?>B;>?AA+@DD88-6$)$$58=<=408908')+><@<?31803>?>7>C<A<60)5-293855--3*$1-&),%2-*-ACEA:;0%%<>FGPE@A;<07873**.$+&,+'''61,=++:;?AFHABE@F@89CC>@>9:<:7?0:BA<;99KJHCIJ??>?<0:<>::++AEBBCADAB?;6+@B9=C@EGH?55?<145-,4#&==;@/*69<EFB;@@B=?AC@C@@<@4B>89?89:*.8<:,(05329..0*.*,=8<:@++)252@C@??KF321><:>9?69>B>97?67AEC;D:7/+;---2-**0.968=AD5HF?DC?>@,2/,+&'$'.,&$$4786.=@6,--*&',/AA>IDIHB8;<8<<087:<@CKB8:8<0-6&1)8>CE><6.5&8801?@+*<<:BA=$$6)&658130)*3+2BB-':<32,/4&0635??>BD=A@>?2369A;3+,#$8;:>@:<CD?2/***,G<A<==<C;920+* +@SRR11410539.234314 234314/1 +GAGCCTCATGCTTCATTCAGGTTACATTATTATCTAAGGTTAAACAGACGACTACAAAACAGATCGACAACTGCTTAACTCACATACAGACATTACAGACTGTGTTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGTACATACTTACCTTTAAGTCACAAAATCCTTTAGGTTGGATGATCTATGTGGCAACGGCAGTACGGACAACACGATGCACCTAGGGATTCTTGATCCATATTGGCTTCCAGTGTAACTGTTGCCTGACCAGTACAGGTGTGTGTGTACACAACATCTTAACACAATTAGTGATTAGTTTGTCCCCACTAGCTGGAAGATAATCTTTGTAAGCTTTAGCAGCATCTACAACAAAGCACAGAAGAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGGCAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTCAACCTTAGCCAATGCGTAACT ++ +$###$%%$%%&&'%$$--+,)'***)'(#++$($'&&+*&'%&%%&(++'&.1--89>=8;;4-6675('(*)'''01/05,2.'&+'(%'*+/%++8:*@065430/+')-;2.:<<0956-4145+19..10./222+1'064--20.;;D73A@;56:;<;7;7875735B<:9925''.''%"&)&*.2<A>:5>22*)500.'':230)1/29$+975120-/,.*)&*+.*0+5&9<A>C@<9:?;88:>7::>@,209=?@;9381)+;@@DF>85901--'054$+'1&*'--731,,6>>@AB<:8C?>>>9118=88/)301B7;<?G==<35/2.')'+%5..28:??8&&%%/-/0),*,71898B.%5&&***11?87727,%&4:3**++8/>>?679=?5=.(.3=>=AAC//ADBICEC>=2).((-974<4==;5:52'%$,CBBD?;EGDCA137:96)'785A;7D..-.&()$($%%##%-.*)1$(,-&& +@SRR11410539.2477472 2477472/1 +TCTAAGTACGCTAGTTGATTACAATATTATAGGATTAAACAGACGTTTCGACAGATCGACAACTTCACCTCATCTTTAAGATGTTGATGCACTCTGATAAGACCTCCTCACGGAGTCTCAAAACCACGTACAGTACGTCGCGAACCTGTAAAACAGGCAAACTGAGTGGACGTGTGTTTTTCTCGGTGAGAGCTCCAGGAATAGGGCTCTCCATCTTACCTTTCGGTCACACCGGACAAAACCTAGATGTGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCGGCCTGCGGAAGATAGACGAGTTACTCGTGTCCTGTCAACGACGGTAATTAGTTATTAATTATACTGCGTGAGTCATAAACATGCAGCCAGGTGACAACCACCTGAACCCTGGGATCGTTTAGAGAACAGGTCTACAAGAGATCGAAAGTTGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGAACCTTAGTAATGCAATGGCTT ++ 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+CAGTGTACTTCGTTCAGTTACGTATTGCCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTATTAAAGAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCTAAAGCTATTAAGTGTGTACCTCAAAGCTGATGTAAAGGAATGGAAGTTCTATGATGCACAGCCTTGTAGTAAAGCTTATAAAATAGAAGGTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTGTAGGTGCTGTCTGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATCGTAAC ++ +*%#&(*+&&+)29+=7=DEF98<<8;51%$$%.@NFEE>6,/.5;:>A8399*'&)-.=C?E@F@II@AHJ;DE895=;CEEDD>CF>ADAA>8;8;DD@44560/%&%(%%7>?B@@C74242&1592511B<@DPLA=336B*0FE5<69@@D:@7?@0&65:;26533;CB;GFEE<<>3$*)(')*/1?A68@BBFEDG=0/.<BFBCD,.3>?<:7ACJE>;0,/01+&-3.,:586@343,=:=750-%&%)(/=:56226;94*&&%'3357:?:@ACD4,%)(,.,'555=>?A<C?115*'1>B@><0/8??A6.>@;><>@ABA1(27:=B:66:)-.41:;6:>B?<>BEDIDHDI>;B=;;B5?=A?>787>?B>HEH::=GCDHBC9=(1>BE=A?A47/0$146=>ED?@B<;@H>>E?<AB?@??@?/($..1GGKABELBA<>>/3400.)8<A<;>98C4480),'24?>&('+.D;=<;76210$$)+'+,(+(.0--+,#$%$&'% +@SRR11410539.20470 20470/1 +TGATGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAACCAGATCGACAGCACCTCATTTCATCTGTGAGCAAAGGTGGCAAAAACATTAAGGCCGTTCAAACTTTGTACGCACAAATGAGGTCTCTAGCAACAATATCACCAAGGCAATCACCATATTGTTTGATGAAGCCAGCATCTGCAAGTGTCACTTTGTTGAAAAGTAGATCTTCAATAAATGACCTCTTCGCTGATTTTGATGAATCTGGTAATATTTGTGAAAATTAAAACCATAAATCTTTAATTGGTGGTGTTTTGTAAATTTGTTTGACTTGCAAGCTTCTTGGGTGTTTTGTCTTGTTCAACAACTATTCCAGTTAAAGCACGGTTTAATTGTGTACAAAAACTGCCATATTGCAACAAGATTGCTGCATTCAGTTGAATCACCACAGGTGCTGTCGATTCCGATTGTAGTCGTCTGTTTAACTATATACATAATTT ++ +%34&&8%89;<<K--%8=BAA@DAAB>>A>>+8.2)''.,-25?@>?5-57>)5.0=8??E>>@CCBAHB9@EJB?>F?<=;8@996&+09013.35/+.*%'/00,,-+--&')%;==7*+$&+..1/1<3811?58-8*/'1%%/>A>4/2'%.$%('2--.0202265CD=DDCB@852),.),*;A?EIAD:=:52)*%&0<GADBBBC:56:?;>>AJ9AEE?>@C=::B<;=8-%#"(*$$)/'%4+,%-7A9.0<:733@DH7===?:235;<@279*)&,;>@SPI@BCC;?>48ABCCNL?A882?DK@@CB<7&&&%%01)<A><88%&&+$$%+2;?B?>;@A9015&&,>@=A(.23JGDE99A>CC?HG;22.4>%87;<EEFI<<>@BB6..481<=9B12-55=AAFA):A5;2?<A?AB??.@<93+129,9:2;>BAEC++)$%*3,22:=778,,01-011++(%'%'&%$$##$ +@SRR11410539.860199 860199/1 +CATTGTACTTCGTTCGGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTTTAGCTTGGTTGTACGCTGCTGTTATAAGTAAAGGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCCTCTAACACAAGACCATGTTGACATACATTTGCTAGAGGACCTCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATGTGTGTGCTTCATTAAAAGAATACTGGAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTTGATAGAAGATGAATTTACACCTTTTGATGTTTGTTAAGACAATGCTCAGGTGTTATTTTCCAAAGTGCAGTGAAAAAGAACAATCAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAAAGTACTCAATGGTCTTTGTTCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +##$%%''78:<8G0?%,064.(0*+.*.,1&?KI@B)9**7<>>?:0;5678.(.$792:(.,*//+.+,BB=<<<>BEKCHEAFBF>=I=FD=955$('*''-0/2.<=:;KLBD,C<;79=<A=8=?;87,-:>;BC>?=?@;=H?88>A@F@F@B?;8:83-1<B:=:9@;?A?@?<5;<?=?=?;ACCA=>=?9>5/*+&#$(%')($$%)&$$%&*-/'<=ECF;:)#(@@CCAE;<F>?D9896CBN@:66-%%,.0@=:=>6:98JL@(%-*2/++'&6;AA?@?:0>6<B?A3422;==;61///384+-0)&3343%%681:7:;66178>C?>@<@?HBACEC?GBD:9;*-;B=CF@BAE9;458769;=?DC-1BB5/=.+)+7--=7.'/8AADD>.0(3688$97<?;=;A5:AE9>3+55?4<==:966<.?IHBG?EGH@9BDEQ:07,,4%%%%76AD=AB>:==A>>@:C7/5-=BAB=@<DDDCA?A>FDC<?99:94<@9>AB:&'/2017037754/++''% +@SRR11410539.432634 432634/1 +CATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAGCCTAAACTACCAAGTACCATACCTCTATTTAATTTTGTTCCAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTTGTAACAAACCTACAAGGTGGTTCCAGTTCAACATAGATAGTACCAGTTCCATCACTCTTAGGGAATCTAGCCCATTTCAAATCCTGTAAATCCGGATAACAGTGCAAGTACAAACCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCGCAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTGACCCCAGCAGTCGTCTCTTTAACAACAACAACTACGTAAC ++ 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+CAATTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGATTTTTAACGCCACCAGATTTGCATCTGTTTGTGCGGAACAGGAAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCCTTTTAATTGTTACTTTGGAGTGTCTCACCAATTAAATGATCTCTGCTTTACTAATGTCTGTAAGATTCGTTTGTAGTGGGAGTGATGAAGTCAGACAAATCGCTCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ 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+GATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTACAGAATAAACACCAGGTAAGAATGAGTAAACTGGTGTTAAACAGAGTACAGTGAATGACATGAGAATAGTAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAAAGCTCTTCTAAACCTCATAAAATAGTAGGCAAGGCATGTTACTACGATGGCTACAATACTGCCAGCTACTATAGATGCTGATATGTCCAAAGCACCAATAGGTTGAATTAGTGGTGTAAACATATTAGTAAGTAAATTTACAGCATCTACACCACAGAAAAACTCCTGGTAAAGATCTGTAATAATCATTGTTAAGTACCCATCTACCACTAGTAGATACACAAACACCAACTTCTGATCTTCACAAGTGCCGTGCCTACAGTACTCAGAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTT ++ +&$*%-%36;:<K<@8:FCA.>A??A3/@;;3CDFHJG=A<A9?<83(278%3%('%%5;:>+A&<?FFI>CEA@G><:53)(4**/?CC2BH+78@>GJ;9<;A>HDCCD=1''&$+,688ADCC:>648/*+58@BH@=67//+4&&&*2+<B@1)3B>;698<@BA<<<A=<>OQ?,5B:;:8:6@CCA>F??BFMFM<G?9=8<<=?DEFIADHEC><=7./1$-;<>>C5,+$%%67@CEEIBEEB=>8CA@6253A<;339*+).;;77CD?F9BBBA>=6879B<<ABA?HD>:FFKB12>8:=CHI@HG3*+133B>DFD@F>2;<?7977?6?D79B47G<<52?:<C>:<GEGI?BAGG;=@78>=:HEAB<<?82>??5.7-6-8?AA=BDE<88CA96)).(+9:;=?4324=?>K>BA':A@>;>>;CF61364.0.,AEG=>>:76==DB787C:F9@B<9969;A=74+ +@SRR11410539.2047746 2047746/1 +CGATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACGGCACCCGACGAATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGAGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAGGTCCTAAAGTGAAGTATTTATACTTGCATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCGCTGGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTATAACCAATACAT ++ 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+(#%'-.*,,-*;B?(-'-88/*+3398,(6./0>><98+(($%$%,,5:/63477&$(48837//%$%%'/1><EI;DC56(+%&,)-&&%&-(-+266&*0655=>:C@;9++BC=81:)=A?+)%('&%%$.#$2,>>AGGJG2;3.1:;8<AF@:>:?@=:71---1''-%%,%%)(**/5;::;B>@EA=;.**9:8<B?BC:?;9@@?3%335<=0<A==:952&2*.91.3..3;7/03,19<19/1.&+(($%($#%55/('%$%%)&+)%&,1$-??-.5;;89:0(&D@H=:;;=73,&%$*%(&*178>ADD<5566'+/--.%-*&*--1>@6/*+61,711.@AFB8=@DG?CAA?5-4,.&$)/0.5346>><=742,%$&)')%11,.2'-'+0+9>@:=;FA@DCBKDBB@F:>>6/''$%'%###$&%(%%&$'($'$$($('%$%)&-,87=@68:;:3,/..5527:3=?F=728,69<<AA>@:42+) +@SRR11410539.2159471 2159471/1 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+()$%)1-<>CC?L(0%<9;8<>DCBC::9()*>JCADA8))0)1012:9<=1?8;05/6:GFGB<=:7/01*-.=:<?B<:>@707.AB;=JC90087559,(1=8@B@B?661$%-6<><<8?<@AK=@BDEA=@<6=;B>6@<;9=223<@:;:<<@>74:@=8-A+9IFGAADD?EHHFIEA;<0.-9<=<77<@:5C<76:%&:=?=298::FEM=9@C@C=57FB>=688B:?FC886BD@CBD?<CD?HN7152/7;8<;<8JD;;2'<'1///@BC?<9<8897BBC@<A@;D>C==D@CA=ACEHE;:>><;<A<=1<?9?4?BCLHE?><?>8-?7941,-.@:>C?8,,&/%$**0&339,459=<EABBC??C8>=FI:6;=BFB@A4897==4$133:867>79=BC64/0051*7259;8754..410/(.094-2024?CBB?:>9<HA;><FDIBFDC;=<<A<=A@?<=<(-/$&63,**%&$ +@SRR11410539.1450863 1450863/1 +GTTGTACTTCGTTCGGTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACCACCAACCTTAGAATCAAGATTGTTAGAATTCCAAGCTTCTGCTTGCAGCCTGTAAAATCATCTAGTAATTTATAATTATAATCAGCAATCTTTCAGTTTGCCTGGGCAGTTGTCTGACTTCATCACCTCTAATTACAAATGAATCTGCATAGACATTAGTAAAGCAGAGATCATTTAATTTAGTAAGAGACACTCCATAACATAAAAGTGAAATGATGCGGAATTATAGGACGGAATAATCAGCAACACAGTTTACTGATTCTCTTCCTATTCAAGCATAAACAGATGCAAATCTGGTGGCGTTAAAAACTTCACCAAAGGGCACAAGTTTGTAATGTTAGGAAATCTAACAATAGATTCTATTTAGTTTGGACTCTAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTTAACTTAATACGTAAC ++ 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+CAAAGTACTTCGTTCAGTTACGGCCCAACACTTCATATACAAGGTTAAGTCATTAGAGTTGTGGTAAATCGATTGAGAAACCACCTGTCTCCATTTATAACAGCAGCATTGCAACCAAGCTAAAACATTAACTGTAATAGTTGTGTCCGTACCAGCTGCTTGTGTGCTGTTTGCCTGTCAACAAAGGTCCATAAAAAGTTGCAACTAAGTCTGTGCCAGCATGAACTCCAGTTGGTAATTCCATATGGTGCATGTAACAAAAGAAGACACAGTCATAATCTATGTTAAAACCAACACTACTGAACTGATGATAAGGAATGAACCCTTAATAGTGAAATTGGGCCTCATAGCACATTGGTAAACACCAGACAGGTGAACAATGTAACAAATAACACTGAAAAAGTCTGTCCTGGTTGAATGCAGGTAAGGTGCTGTCGATTCGGTTTGTAGTCGTCTGTTAACCTTAGCAATACGTAAC ++ +4#$$$''.058:L<;77>5+3./...(*-:9;77&#,*,<79;3CFCC:<@::0:'(5(,>A>A>4468A?>G<87)132(-:=<=:89@=@?@?74=762%*,&*+*,5%44377017=:@A8.:6347.+:<>>>82@@C/5:00.&-1;:B6<>5..4-&$(013276@9>:D>8C--7;<%)+))-+3?@A3359=07&&$%---)/.';<>?@C8/+),)79*><?AB47C>A9;9;9<>>><?@<?ABA98689,&&%&$8:=@859;<;??9?9D?A??<?@:57..2)&)&%''$$#'&&''%&'',(/4=;;ABD669:?7?7:55255=<?=;;IB0BB@BCD99:23;46-762.&''$#&3,0,*%#$%$')*012)*)**20/-0/L?5;9;>;99;<9;=D99C.-0&'%#&&*9*.8C>:AE?C6@CBDB@@DEB=?95?316*$%%&%)...77<=:<;00' +@SRR11410539.1083446 1083446/1 +CATTGTACTTCGTTCAGTTACGTATTGCTGGAGTTAAACAGACGACTACAAACAGAATCGACAGCACCTGTTGAGAGCAAAATTCATGAGGTCCTTTAGTAAGGTCAGTCTCAGTCCAACATTTTGCTTCAGACATAAAAAAACATTGTTTTGATAATAAAGACGACTTAAAGTTCTTTATACTATACCACTAGACGAGATGCACTTAAGTGCTATTGAAACACACAACAGCATCGTCCAGAGAGAGTATCATCATTGAGAAATGTTTACGCAAATATGCGTAAAACTCATTCACAAAGTCTGTGTCAACATCTCTATTTCTATAGAGACACTCATAAAGTCTGTGTTGTAAATTGCGGACATACTTATCGGCAATTTGTTACCATCAGTAGATAAAGTGCATTAACATTGGCCGTGACAGCTTGACAAATGTTAAAAACACTATTAGCATAAGCAGTTGTGGCATCTCTGATGAAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +(&')'((674::B/<59FD<:684?B')/$%$9NEAEE945?BHI?CB>==6((%.1:=CECCAADB>I<?@DB>7<DGID@@CG66,--A23<;<95,,++'2(<4:<?A5,<22C78D?ABK=2;A*CA>CA>9EHF4252>CCF?FDA@224'+3,,(&,$(&@GFHH46EE<F>9,%%'&%&#$%.*2003.&)==D@@<,,0@B;E?>>8>>34=<>@@FD??7E4CC<@<%%:@(((2168::58DCB88413+(5411LDDA::E@A@@>864/012=@:C<@B6<B@DC@<<@@ADF@D<>AFAC1;>7C@>@;=3;;:6;;.=>C>:FI64152<FCGKCCAB@EB4817C>/''',,?9?'-6$'$*<,80%033,>/0572CADHB1IGJIHG>>LGKG>@CE?BBA*,&'(*439.042/;>GJKA-'1//514?48::34-/./<@5*8/7?>C,8,=:1;.,020-/577=@@B9;7JHH@CA8.<98.7=47876:99<97@;:66FDA(5% +@SRR11410539.74585 74585/1 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+CGATGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTTATCGCAGAAAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATCGAGGGTGTCATGCTACTAGAGAAGCTGGTGGTACCAATTTACCTTAAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAAGGTTATGTTGATACACCTAATAATACAGATTTTCAAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCGCCCCACTTATGTACAAAGGACTGCGGAATGTAGTGCGTATAAGGTGGCCTAATGTTAAGTGACACACTTAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGAGCGCACCTGTTGTCTATGTGATGGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ ++$$$(.2/0320<:D<AFHG>=@<65'61:*<9<?B2:,,:BA>7-0/<<34/21978=@1B*44@?=?@AD='%*$)-,21)''AA?;455;:C<;86;9ECFAGAE@H=54-45.&%.-2'/+57756;=88<91+4&)%33077-&,+-1068:;9=;00103+4%:7C:CHDSMGAD/>=9=?GDA?A:/<;>BD0/?:<672$+-$%1AC<549::=78;>?=3<A?825346<<=HGC+0%&58B=;1563+99;'782;@?CA@0,8'%27+.+.()*%46::)4%%%%%33=>:95.*688'9>752++77BE=;2/66/'*'(///'',#$$%$6@<?E@,--A@:;89:666<=>99;-6A38823/.:76'**48<;9===9414359861)(#%'(0-;B=@82+)=/AB>>9<B><>B5(''':?@):(3&%2,,<>?CBAB86;<?;8<88>(+$;>:9EC=ABA?>9<;975*+462758;9>=>;44%($'+%*7:@FB;9++$( +@SRR11410539.1178449 1178449/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTAATTGAGCAGGGTCGCCAATGTACACATAGTGTAGCACGTAATCTGGCATTGACAACACTCAAATCATAATTTGTGGCCATTGAAATTTCATCAAAGACAACTATATCTGCTGTCGTCTCAGGTAGTACGTTACAGTACAAAGACATGCTGTTCAATGTTAGATTCACTTTGAATTTATCAAAACACTCTACACGAGCACGTGCAGGTATGAATTCTACATTTATCTATAGGCAAATATTTTAATGCCTTCTCACATAGTGCATCAACAGCGGCATGAGAGCAAGCTGTATACACTATGCAGCCCGAGCAGAAGGGTAGTAGAGAAAGCTAGGCCAATAGCAAAATGACTCTTACCAGTACCAGGTGGTCCCTGGAGTGTAGAATAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTATGTCATATATT ++ +&78;8600.6=I==8=B5,=8A=B>52-%%&9>=ADB?9;??BE@FCC9<3A=>6=?==E>:AAA@CGAEIHIE=8:16/7<8444415992.//9:4/5?6?@EDEB@>?<496(..*+2955;;@=CCD@A@<C8;7=7:E;A8?CD>@;224<EHC14/;89%+7@88<=BED>BC4<9?:?8<=)3+10(&$))5-6;6783=8=9:&)@><--97:A,)45-.56$$8=13//885&&'66>=<>;<;C:<<A?>713034$<&74819778?8,&,&.2),<>:GLID<=0)5122448>7:<>D>>?DAB?9=E>G<CBB>>AD?76A33-,)52:D9<>9-459/11859578;979<66(%%+&)()'1)%*&++%'.)4)*'#'%'(,=:**9;>A8/,--8:7=892<?70.+22,:BAE3B/;G=?8;?HH9<6AB>33+14654<689@8<=>>@;*+''*<@FD;>9=>;@AA8679;83$$#%%'%&&&0* +@SRR11410539.1092856 1092856/1 +CGACGCTTCGTTCGGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTTCATAGCCACAAGGTTAAAGTCATTAAGAGTTGTGGTAAAAATCGATTGAGAAACCACCTGTCTCCATTTATAACAGCAGCGTACAACCCAAGCCTAACAGTAACTGTAATAGTTGTGTCCGTACCAGCTGCTTGTGCTCTGTTGCCTGTCAACAAAGGTCCATAAAAGTTACCTTCTAAGTCTGTGCCAGCATGAACTCAGTTAGTATTCCATATGGTGCATGTAACAAAAGAGACACAGTCATAATCTATGTTAAAACCAACACTACCATGAACCATTAAGGAATGAACCCTTAATAGTGAAATTGGGCCTCATAGCACATTGGTAAACACCAGATGGTGAACCATTGTAACAAGCTAACACTGAAAAAGTCTGTCCTGGTTGAATGCGAACAAGGTGCTGTCGATTCCGTTTGTAGTCATCTGTTGCCACTAGCAATACATATAAC ++ +$$#%$%)*/6:/:%*9;6+((('*69.8,FHB=AE6;64/*)%'((,.001685/44:86;<>A@GBAA@@5:5233??:;7=>@>@</<@@A<?D63>244.%-8<>AF?:?CBB620/687=?1AA@::;B4867<@@<=<85;1-2++*..+*'((*++*('$&%+$1237:98550/67;'0855900,<72=<>://10/'%3,149:+456/--*).==)2?78;7(>>135HHB<BF@=;=>;9;1,(''*7339CABFE5B;??0'0/503:>>?A?>B@B:4$$)))***'%'78??D40?7=;<BD=A>F=@;>DHOB;:80-55.-.,.<=>F>>888DC:BEIE77@HB88>;=1;:533,--328?@?@8))+*+$,&&(.24-/+.**69:;A;<BBA@755@?9><;BBBBA?B=:=9=>DQK?6.56B?77=::=BB?DA64;4578>>+@B=;9238>@B=+.;??B:36674(-96450##'&$+'&'+,)(/-**2--( +@SRR11410539.1753754 1753754/1 +GATGTGCCCCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAACAGAATCAACAGCACCTTGCCAGAGATGTCACCTAAATCAGCATCTGGTGATGTATGATTATTAAAATATTTATCTAACTCCTCCTTGAATGAATTAATTCAGGTTGTAAAGGATCATAAACTGTGTTGTGGCTTAATTCCTATTACAACATCCACAGTTACCAATTCTAAATGTGTTGTCTGCGTATGTGATTTGGTTCATAAAATTCACTTTTTTGTGACCTGCAAACAGTGCGCATTTGAAACAAGACACCTTCACGAGAAAGTGTGCTTTCATCATATGACAAATGGCAGGAGCAGTTGTGAGTTCTTTTCTTTGTGGGGACATAGTCATGCAAGAAGACTACACCATGAGGTGCTGACTGGGGAAGGACATAAGATGATAAGCCCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCTTAGCAATGCAGTAAGC ++ +##.$%#%%''05@,71657)40)&/2(5878+5,2)*/3%%1/3-++464/1));;=,*17*5*--+-(+05694<..5;/-&5%,4-,3$5??GE=?DFCFB:98328,$(*2464,,01=75:3)**72888>89626+)$$$&/2.--'0005(%.1)*><69==CF?>@4648;'+')''(465935.8-1+33229-.5()%'./+$0.0..('()/.,4,8<,662&(,*(%%,3+38(,0317()*,)()--&$%%%$$$#''%'((*122)+,%;'$()--/,'%*(.%&0:>A4=2/5&533+,1(,?:=:8991,&%'&&%57>EFIIF=?953971/-=B?2$$-%,3:EDIB8::6.('*67/.&&(*41-,*-./10+65**17;;<;;;)&<?9731,-,$&44%+/.$&$%$%7;8408011'831?;DE?;96644DH:=8<<A;5486-'8>88;?+6$,.-+**,./*).%%%((*( 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+(%$'*64?AC@AA1@9=BCC85>?<1&9:0031<<BD=8'(-(../1/-771**(,365C:7ACHH?<===45()6<=;>D=BD8;JLHAD8:EC7?D>8AD:=>6567,,>=@?=.015979<1?+47==9)0'==''++6A<;==<;;%&=1-1/.,-0//44;887=A43/3?=@>239;240.,-1?BEGABD@D;9<89<@@BEC60073222216:;><;A7<B;<<=??<BE@AEB?@D?:@@A7**,8959--84%%4@-AE8B8EF:<5989IHB@5=<=/+%%.8)40129<>GE@7:6?@A67757;<12B@>?>DC@EAD>>D4:.5-'1*6--/.<C:CAD@>C=><>>*8<DECA?A>ACADG.*<649C8:?=48<>34;F<@BE66B?<29@''>?<+4311'/9AC>A<:9830+178;:>@(+35>><4;*0%'/5;>?CF@9;=C@7AD?=A@?@>BBB;@A<><=E36;<>?;10(2''++ +@SRR11410539.1896966 1896966/1 +AGTGTACTTCGTTCGTGCGTATTGCTAAGGTTAACTGCAGACGACTACAAACGGAATCGACAGCACCTCTCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCCACGGAGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAAACAGGCAAACTGGGAGTTGGACGATATCATTTTTCTCGTTGAAACCAGGGACAAGGCTCTCCATCTTACCTTTCGGTCACACGGACAAAACCTAGATGTGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCAGCCTGCAGAGAAGATAGACGAGTTACTCGTGTCCTGTCAGCGACGGTAATTAGTTATTAATTATACTGCGTGAAGGTGCACCTTCCTTTAAGCATGCAGCCAGTGACAATACAGATTTTAAAGTTTCGTTTAGAGAACAGATACAGAGATCGAAAGTTGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTGGCAATACGTA ++ +#'#$&$***9;>+,$*&.,623:;@:89);><:,$)#'%,%497:>;<EE(<&--98A=:3.66604/7&.98,(6;66:@::=@EABB/?BB@>9..013<;9:;073/99<:==>+):*;55)&B<6/*1.7,,7C@C<;C;?@?=;?:4:?AD=/'13679+//-,)$*'.;>=5,,'%&%$-//,5309:F??6=>>80<AA=<:;?>87/C<@8ADIKD8>DE>E40&<15+EBG@CFFB8?A6%%2'7A<B=B?HGA::7;3:8<>;AB:=BC8,+19A??===/<;5@A>21.-'&('0789=;;449AD><;<:B?++01)/*/'.>EI3<JEHIB9;FFB?BCHCA-)),46662/..%(<.*$#'+.#*-//009>9114,+$'&(864,%%"%%%+((*(*+-+&&-A>=ID55311168551(''-*,(3+::;C;?KD:=BC;><:6-A/:;:7==9;<8<@EDIBABB:6<<@BBEB4+,,0--(//+*'&(#%$ +@SRR11410539.209013 209013/1 +CGGTGTACTTCGTTCCGGTTACGTATTGCTAAGGTTAAACAGACAGCTACAAACGGATCGACAGCATAGGCTCTGTTGGTGGGAATGTTTTGTATGCGTCAATATGCTTATTCAACAAATGACTGATCTTTGAAATTGGATCTTTGTCATCCAATTTGATGGCACCTGTGTAGGTCAACCGTTCCCGAAGGTGTGACTTCCATGCCAATGCCTTGACATTCCGAAGAACGCTACAGGCGCTGGGGGCAAATTGTACAATTTGCGGTAATGTTTGTAATCAGTTCCTTGTCTGATTAGTTCCTGGTCCCAAAATTTCCGCCCGGGTTTGTTCTGGACCACGTCTGCCGAAAGCTTGTGTTACATTGTATGCTTTGGTGGCAGTACGTTTTGCCGAAGACTTCTTAGAAGCCTCAGCGGCAGATTTCTTAGTGACAGTTTGGCCTTGTTGTTGTTGGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +,$&&'*)4541005$&$*$653+/((*/:A45+=G>13)'$)%)%$%&#$#$$/%).$$//((%*'.,8<ADBEF>=36@47:@F9:?=HB@AAB@>>=@::<=<<=BE@AB5''445*101((12;>@?44*))*08==67///,'(&//D)))FEC=@788AB?B7)9+'9>9A3442'25'-8;::.5B'596CPQBH:/*%%$$'$##$)63;<=>,1<6,-,-''12(())12357*,/)*.''$+401,3#%+->4+81)=C;<??K<<972@=AEA<>;C?:?@D>O5-39=;;H==99@>@A9DADC)+$$%(&,>CDB@<8=<?@G55/0=9<1.,*((&&66663A??6-;<DHB;<>?>CC?$,815/->>=CBJGJ:4521+.1%(6:;4564927=:63-(($)'-%%%&-$$)%07<A52+:=D<=7)2??LO8MI:E?2***70.,**(7.=>AE1?:C=;1*30:>??0F?C?A22.-.-*79;;;<D?A>8''+ +@SRR11410539.393760 393760/1 +GGTAGCGTTCCAGTTACGTATTGCTAAGGTTAAACGCCGGGCGGCGACTCTAAACAGGGCTGTCGGCGAAGCACCTAGGTCTTCCTTGCCATGTTGAGTGAGTGAACCAAGACACCCAGATATTATTGGGTAAACCTTGGGGCCGACATTGTTTTGATCGCGCCCCACTGCGTTCTCCATTCTATAGTTACTATAGTTGAATCTGAGTCCTAAGCGTAATGCGGGGTGCATTTCGCTGATTTTGAGGTCCATTATCAGACATTTAGTTTCGTTTAGATGAAATCTAAACAACACGAACGTCATGATACTCTAAAAAGTCTTCATAGAACGAACAACACTACAAGACACGAATTTAAGGTTCCTGGCAATTAATTGTAAAGGTAAACAGGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCCAAAGTGCTGTCGATTCGTTATGATATCTGTTTAACCTTAGCAATACGTAACGCT ++ ++1544/$$8%)$67=:;776789;=77).32-.%&##%&,.1&'&*$#)($&'(*$)%$#($-0#%'$$#+88?<:=6B5'.69::>>CD@?BA?32?03*0.88>1>5626:((1'$$$)&&)%%*,/0301%$+$%%'8660,%,#%+)6?>7877><-ADDDC3699<6?:;=7?=>;7.''*'4943*#'#%%')(/8802*2((-)(*%(%)+++'7$(38CBA;<=D:('):8<71-+$$@9<C:;=*$4)+4169;6.794>?>RM5B1B;@8:/'5&'('0((',4220++9;35665*#'?+@B?1,3=@IH??;>@?HC<=B?448454058882',5-2-36-$$0;A@:;@::;(*(3?A>B>689+'0'%'.5$$$>DGCC@@<IEEEIDGF<=,01<8A93;3:AFEG?<=A9CBIH==79CB5B.==C$;23**A:95575314))***#%)&''.2+)0370125214(44588700))%##" +@SRR11410539.1505449 1505449/1 +CGGTGTACTTTTCGTTCAGTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACATAAGCACCTTCAGGTGATGGCACAATAGATCCTATTTCTGAACATGACTACCAGATTGGTGGTTTATACTGAAAAATGAAGTCTGGAGTAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTAAATAAAAATTGTTGATGAGCCTGAAGGCTATGTCCATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTCCGGGAAGAGACAGGTGCGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +%%)'#&%%&&'+.997.(-+//-5227/.8/2*@65352003.1BA?B>7:6%0%%%.4862+$%&&'8?=<@9+$2.)+7940+).&&&%$&$$&+888;9-(%&'.;A?<=??=<=((,&%/$'(.,/++..((BEB:21220:=845'5834%*$&0,-((.,*514-*3.)6;>::;390086.309>5:,15B>:99>61'%.'./<->34368-:CBA99G=<>?9<=E;;6798D>?D:+>>?><A<3&$.'-.($-.,*(18<@CB?>@;2+/**(%$%%&588++1,&+?:@:;==8492B:>?;>;//3$($?6;,21*1&&/0(*-.1-/%(''<=;BJB@?><89=601...//<<9>@=<6@A>'?<;:<>-(:+?@>A@<;=>:0.-/B>=88=BGGD;>@33D@?AA.)89)3(,)&,&0-24,,%&$/4:C;<>@>>=880+999=;669<?>HHC;AB93330/35;66=:9A4.A<?>=<?>C>E==?:41(4=@B@@>,,*))()()-*&$($$#$ +@SRR11410539.2437535 2437535/1 +GTCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACGTGGCTTTATTAGTTGCATTGTTAACATGCCAAACAATAGGTTTATGTAACAATTTAGCTCCTTTCTTAAAGAGGGTGTGTAGTGTTTATAATCAATAGCCACCATCACCATTTAAGTCAGGGAAAAATGTAACTTTAAGCTCTCTTGAAGCAGGTTTCTTATAACCAGTTAACTGGTTCGTCATCAACAAATTTGATATTATCACATACAAACTTAAAATTATCGAAGCTTGCGTTTGGATATGGTTGGTTTTGGTACAAGATCAATTGGTTTGCTCTGTGGAAATAAGAATTGTCTTTCTTATAATAATTGTCCAACTTAGGGTCAATTTCTGTACAAACAACACCATCCAATTTATAAGTAACTGGTTTTATGGTTGTTGTGTAACTGTTTTCTTTGCGGCGCGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +$%##=9:H@<78GF>:8977:448<=*AJFDH@597:<52.)()6866'-/7;:>;+768BEDB9??G>B//A=864013803..009=>A@<0167>@C@DF/:,8C@:@330//%)-)/C?DAA;=AAE>G?88),*79;=:13'$0=??C/$%8:7<78;66:=?>*>A?CCB?AA=7::4/%1=6ANJGMC=;85-:=??AA@D>G?9;ACE9;:>@HCC=7::C56<?<ACBA<59/21,$#')53>++2AABCFC?@4-G>A<=.:,((<:;AAB=FJIG>@:3900>>FMKE@>LJG6;?==;*0>@9:LKRF<BCD;@AAB>A6768,289I))CA<59%&)-;<8;'/44=F?@DIMEH705?DEDFDL::;BD@AB@>??4+?6:69CFCDB@?AFBA8971>?D&&E=>=IGBF0BFDBA:;>?+ENCB@)/<@:AIBHHBA@<EDECQF</@2'##%%$&(99:@<8CDAIA+.8@BJA9C69=<<=282??..>><:3/1==89B<9/-& +@SRR11410539.1908484 1908484/1 +TGATGATATACTTCGATTCAGTTACGTATTGCTAAGGTTAAAACAGACGACTACAAACGGAATCGACAGCACCTGGTGTTGTTGGAGAAGGTTCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCCAAAAAGAGAAAGTCAACATCTGTGTGTTAGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTCCTGCTTCCACAAGTGCTTTGTGGAAACTGTAAAAAGGATTTGGATTATAAAGCATTCAAACAAATTATTGAATCCTGTGGTAATTTTAAAAAGTTACAAGGAAAAGCTAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTAGCCGCGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTACAGAAGGCCGCTAGGTGCTGTCGATTCCGCGCCAGTCGTCTGACGCTCAACAATACGTAAC ++ +%(&*$$&'-,,./&$$(-4-7@D@>;>;:=;6'89(@AC>=9'9--1+;;;957:;94)/46939-.(,,,9:9))=768/@<;<=8:<+89)5(().37748B?BEC:64$'$$&%&&+563313$'$@A:%$(*&...1:>01/.,+$$(,)+'*&/8:;BFE925566789864D'4../-**077:5FFIG68>>:9;?@>%3(./0137-6:2/405777%4,-04857-/%)('&,,%55646;IG;3:=86?DH><;<.6./,,-''.>AA78;<51+19@@>ARC@@3.-:CEB=AA%658//37+42))?AABBIFJJIEEAA041++46//)81(BCA::/*#%)%%*/;9:B:96=9>?N;C<93/.56@?>76981C8)+$%%%%8<@=E;<:A?858?GE<FBDE@E7<-9;95=;89*+)79<6===DBCH@DD@AB><<7@BABA?/>(?BC>>95</+==))$&)%''',,***)+''&$'&#$')(%$*$%$$# +@SRR11410539.112459 112459/1 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+$#&''%&.19;?;:>81+29>7;%,-45'%/()*=DCBE=8''3)%&$&+&&8:4-%**26?E>?:F>=<BA@A4:),,',??A0))*??=E5929@?8>>?@5$3)1///2=@79:::12=D999I?EFCK=5<ACBB8,,)&&&,7@B@9;=((1)1B>??>?@GG?=34*54835>BG=@9;:JLFB?>%&<+1C==2>15$8::<AHAACC8-,+*')*$,(56@:=B>0004950=++89%3=<:42014&&&(+,04?;25/,(&%2-42323-00():;:;3=C@IFID>5.0A38-0C8?42(62@<?DBE>891-.*2%$#%:;=DA%%>009:668=9;@:?@GF?DFFA762897/+,(7?@@EAA775/1'/28>33:@,+,)&)454>A=9C>0001201','=?DE2AC@5)//74,;27<>00,00/))888C@=9854.459//9%8<>@EF?BBMKI98C76915<0:CDB;=*(((///66>>FDB97)) +@SRR11410539.586359 586359/1 +CATTAGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGTTTCCACACAGACAGGCATTAATTTGCGTGTTTCTTCTGCATGTGCAAGCATTTCTCGCAAATTCAAGAAACAGTTCCAAAATTTCTTGCTTCTCATTAGAGATAATAGATGGTAGAATGTAAAAGGCACTTTTACACTTTTTAAACACTGTCTTTGCCTCCTCTACAATTGTAACCATTTAAACCCTGACCCGGGTAAGTGGTTATATAATTGTCTGTTGGCACTTTTCTCAAAGCTTTCGCTAGCATTTCAGTAGTGCCACCAGCCTTTTTAGTAGGTATAACCACAGCAGTTAAAACTTACCCTCTTGAACAACATCACCCACTATATATGGAGCATCTTTCTTTAAGAAAGTGATGTCAATGTCACTAACAAGAGTGGCAAGTGGATGAGGTGCTGTCGATTTCCGTTTAGCCAGTCGTCTGTTTAATATAATAACTCTCATCTT ++ +$###%$&'-1/4<B<4.9EC=2;00*+++;--/=B@?B=<::<B;CCE@A699@(.'45;@>?@<?7EC40;:?E9;2>GFCBG?99=EBHHEEBJI=:<DA>=E>?:(53,022>7@FD76CELC=EB./;;8>=?--,9:8>>BCB.4::-568/),,+,2017=AA<E36*<6?E=;=;@;<<A=5E?A<43,(8FBA;<<>4,*=8;BB@612%.;<989;?>EB>>@8=@>:24$&$'54--:;?@?>@B3JCEBB=6<726=@=B>=<@9:BB@<7869>9@?A>;2/)$$57CEE8@560#678=@::04(=<>?D?58AF>@?=:7;<IA>>9:GGB<:5:.44;7++;<>7;-,(.%-+.33%%&-:://45683?>333-7>8>>@A9::97)=??B>;>;:BDBH9<<>56+874:C9>?50><>@?9??/9;;:78/1.5665$%%104<52**2;59@4092,66:,---5)$%$$,),+&*2%$(+-%%&%%#$$#%#&&(')'$'( +@SRR11410539.786146 786146/1 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+&%$%))(788&+3:D3@=?BC97222).;BABC-DDEILFB0@D@6533(,0326.2/26087>&'$)57@88>@@@?;91>,('&2/@@C;<JHHGA>GNDDDDFE86:BEAAIJ<==?62:>C014@CCE>569;==))+(23.074413(*,'2,--4<45''7:>779<443<=45<EH9'9A6+-&,545,*,9;<3,(%/4:<<;:9@BF?6773,62C=74,07-1':=F=579CEE99:@@04-=?8>HI?AEHF7FB@?=AL4.(,-6-934<>=38?<AC=C%%<<578:<IF::C<1111;>KG>FFIC57?=?EDDHD@GED@..1BCGCBCAB=?>=92%%:/.44<?FCEA00BAKJ@?;,.8=A>>><82:99D<;CDH?C=++'.5*//('%)27865,+$%$(&4479@EGBCC&)-)7846715297DFHABCAG@>><6+.+2)/1-)246/389;<@=EDK=???8:99,56<<?374+.+1:88;<==<:9(+% +@SRR11410539.194114 194114/1 +TGATGTGCTAGTTTCAGTTACGTATTGCTAAAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCCGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCCGGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGGTCTTGTAAAACCTTCTTTTACGTTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAGCTCCTTGAACAATGGAACCTAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACGTAACT ++ +%*(%#%%$%$(*-05.>BB889:::?@?@87+->>;=:4--@AIL@B<@AC=<8<184.-&('#%"#$%%626=<<6<D:65BA8:9=B461///.?AB<;63(5345912*)398:B9:8;@66((-:9FFF.4063+:0)(55766;<D@HCAD;((CE?@-C,AAA9@GG=OLH;:=:2-./>+(,&*2001DONCDAB>AA;9:B;7889?//6/2;:@8:11BC8...2093A>1,549<8778B?=6368:BB11*)7')-/.AB>EFD;>>??;JGI;4<9F?IC<<C,<>:H@;CHLME4-D0.7/@D@E@B;?8.?;8><@A@AG8F;=6,;0HJFB;;A=GDHC>>C7.465:<=<@LCA@4><:=@CD8:@:=A@FG:C2>?ED18C=<=<;(289?08@B=<907-:;9BAD?;0,*$&+77,3;;272577=GDCAAED>1+8786;-;D@;><8>A<;6689@A;-798:<61,/304''&&&''043.&&B@A95)+ +@SRR11410539.2006663 2006663/1 +CAATGTACTTCGTTCCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTAACTTTTATCACTACGCAACTTAGATACATTTCTTTATTTAACAAAAAGGTGCACAGCGCAGCTTTCTTCAAAAGTACTAAAGGAAACACCATTAAAGACTACACGTCTCTTTAGGTAATTACTAAAGAACCAATAGAAATGCTTTGTGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGTACTAAAGGTGTAGACATAACCATCCACTGAATATGTGCTAAAAAAACATCATTAGTAAGATAAAATGTCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATGAGTAAACTGGTGTTAAACAGAAGTACAGTGAATGACATAAAGGAATGATAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTAGCAATACGTAACT ++ +6+,++-//049;B9'.9:<??6,3..2,>9551:CA?CB:?=?:@@=?<;3522190<<9=3<:<5:@<B''&&&&&:=EC>DD;:;=>++,.*7>DCABDM=LHE@D?@:9/125.%(.@-9889=:52-6%%*4140(@H?33:=48780('6?=?7@BCCBHNB/A22B0;??=>GEMI=@>@=:<9B?;@DHG,BH=<CB986@B<****.>:C:;;@>;A<79GABCAEEBD@AGIAG@B5<&&5?/;86)017));;.+0:.2,+.24>???@@88;>9>@;?;<89=6A9FI;+))*+A<>BI=2<7CGFCC<?9J=:5?24,-,5)*-77:2-**);75=;?A=@B>=A:A>CGFHJ8,,>A?E9AC<<AIHHCE84&&&%'39;<8EECH@??93479$0(897))%,,%'A==>HL?)9EHF@HB:6>>=<B>?669D8=AEC'+9>@>FD;===C?35=CDME@IB;=89<;421-%%#$2(///..<<6>?2* +@SRR11410539.2324982 2324982/1 +CTGTTGTACTTCGTTCAGTTACGTAATGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATGGCTGCATCACGGTCAAGAAATCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTTAAGAACAACTGGTACAACAACAACCTGCTCACCGCTTCTTGAGCAGTAGCAAAAGCTGCACATGATGGAAGGGAACTAAACTATAACTTTAAGGTGCCCTGTTGTCCAGCATTTCTTCACAAAGCTTGTTTCTACAGCACCCACCATGGAAAGCAAAACAGAAAGGTGAAACCATTTTTTTCAAAGGCTAAGTGACATCTTTAGCTAAGAGAAATTGATAGTAACTGGACACACAGGCCTAATTTAGATGATGATTCTACTCTGAGTTGTTTGCAAAACTGAAAATACTGATGTGCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTCTTTAACAATACAT ++ +'$%$%.+*''''-0+-5-86:.(($''%,5//4CIEEF==113/76989>68,2$%5797:1,),--,)24()((#$#*98<&0(($1$%&**'%20159;6C6==7DEHC?@A/6+%-0>==>;:6;ABA:=BC==6-)%($&*&&%&/--7//0)+14+/%$$#$%.129@@77/=>D::BB20+11('$$18337)*,00-%..)1/1$'&$('%$-1,'(-*5568=?>@B=88@<>D@@CACE?0,,..()667:>:922,--+..,**&%+864637-(7>>E?8--7.'.,6388&669:;QIB>:477/15.0%%%#%%%*-,),,6<<90*..%1'/16-%+*3367;=>?;75-.-+(((((00->B?<BB::??BB?>968E@.6)>8=799>+A==@D3.*(''%**+-1)&&99:67%248;:>=<?@99;024<<A6=DA77)%-&+11+))'%%&%%$$&&& +@SRR11410539.2118848 2118848/1 +CAGTGTACTTCGTTCCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTTTTCTCCAAGCAGGGTTACGTGTAAGGAATTCTCTTACCACGCCTATTTGTGGCCTGTTAATTGTGCAGATGAAACATCATGCGTGATAACACCCTTATAAAACATTTTAAAGCATTGAGCTGATTTGTCTTTATGTGCTTTAAGCTTATTATCATAAACCAAAGCACTCACAGTGTCAACAATTTCAGCAGGACAACGCCGACAAGTTCCGAGGAACGTAATACGGACCTATATTACAATTTTCATAAGTCTACACACTGAATTGAAATATTCTGGTTCCTAGTGTGCCCTTAGTTGAATATTGCGTGGTGCAGGTAATTGAGCAGGGTCGCCAATGTACATAGTGCTTAGCACGTAATCTGGCATTGACA ++ +*'$()1/00/*8HD$-0<CCC;78*;=9?2,0BGFGKC4=1;9<:8;@79:./242;<=:9359>?ABH<HFNGCD$9==,B;D:FC;20+4)-:>39?A<:?D@FCDADI=A<?2+CAA76)/::>56<:54>*%%+66?2:1<@<9:81;9;;A89CACBGGHGDGD:BC9FCDCBMEDH</;9:;:8D@@D<BPOA?AMI@=:;?6346<9:?BEFBA=>BD?;DF:;B??>>DIGF>.75;B94=/09?B=?G,='66ABG?A?<<AA@C=9;@AB7<;6(@137)*++1/27;@;9<&$%#$#$%&$(0/6+-(,*9:@A<6+=@BD?>=?@<EHCGD?<=;<E>./)%+=+47=?224;=A&'%&&('/?=>BBCDF<9B?GGJOLFBD=892=<>;<;,,('$$,'247A>:<=<EFBE@CA?<D=<=F??A;2,( +@SRR11410539.114143 114143/1 +GATGGTATGCTTCGTTCAGTTACGTATTACTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCGCCTAGGTCTTCCTTGCCATGTTGAGTGAGAGCCTTGGTGAACCCAAGACGCAGTATTATTAGGTAAACCTTGCAGGGCCGACGTTGTTTTGATCGCGCCCCGTTCTCCATTCTGGTTACTGCCAGTTGAATCACGAGGTCCACCAAACGTAATGCGGGGTGCATTTCGCTGATTTTGGGGTCCAGTATCAGACATTTTAGTTTGTTCGTTTGATGAAATCTAAAACAACACGAACGTCATGATACTCTAAAAGTCTTCGCCGACAAACAACGCACTGAAGACTACCCAATTTAGGTTCTGGCAATTAATTGTAAAGGTAAACAGGCTAATATAATTTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCCAAGGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACTGTGGC ++ +$$&$%&&$$//-,*70+#)$254.(.%&$489:-3/16866&&0)#$#11956/>;?==789344?:(>?23,99:<<()*+0387++34429:<952-$+$$%+'-$$$::78<8'-5.1<861&**$-*7EGA=A8;*#%5'%38;?B=>*)()))*'166/....*8C?@B%:8=98:)/=?:BEDE:90;:8:>4)$$1%23-.:22@AAB*/22379<%.,(99?=DFIB545<;>A=3).;:((3+/116,$)%;9;:77:8>AJ:EE?;JD?67>@BD;581*/.45+,CDB:9=6439+,,6;%$2C2GIE00=DKF=..-,41AB@='',(%%('$BC8@=/((((0402;2>AI5B:>@<''&'(((,',55%&/1$'%%$$$3.--6.,%',/6/37@@FC?BDC<=>>CACAC>/00=>@ER=?66?<;?B>;?%=45%3#6@654*8?;9@A7:<A?5*&$'-,+67/0BEE55','2766;91%$%&,()' +@SRR11410539.1215747 1215747/1 +AATTGTACTTCGTTCCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCACATCCAGATTCTTACCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTTATATAACCACTTACCCGAGGTCAGGGTTTAAGAAATGGTTACACTGTGAAGGAAGTGAGAACAGTGCTTTAAAGTGTAGAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTAGGTACCATCTTGCACATGCAGAAGAACACCTGGGTAATGCCTGTCTGTGTGGAGGAAACTAGGTGCTGTCGATTCCGTTTGGGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +#$##&/0<>@=:C?&.5>7??21:98<6>>@A.>JIEI76<6455350''),/08<<D<;<=<>>?@9:B@'><&&3,*,520+)%&(&:BAFD;A>9:>994&&*;;:;9B@=EFHDA???2,>C9*5DA614-.;.>1>5?1C698B;8598=<@?E56/*-&5*;FA=;:>=><;=8846/,$),;;FF@>GRL1&5C;;9;=:=CABA/.881@;88<:==@0026<ACK@::1:8../@71+'(0108423.21)%&'36<<2432.4>'3$9-&7-6:@;>?++48AA@9<%%0/97980$$,*)%&'&%'(&0//0/*$$%'7;4899+1%,,>5668874(&1><97889626)-$(:78,;+12-*3.982467%47@DEAHD<>A52399<B?@,$($,$&,,,)(*$(((0.('')**%%%.0+-*#%%+00<ADBF8>??3333%)(%&$(7),43,6055-3556.39;:>;4*)(048;=?>8:@78,2,18-/.//.0.,,,%% +@SRR11410539.1516895 1516895/1 +CAAGCATACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAAGGTGTCTGCAATTCATAGCTCTTTCAGAACGTTCCGTGTACCAAGCAATTTCATGCTCATGTTCACGGCAGCAGTATACACCCCTCTTAGTGTCAATAAAGTCCAGTTGTTCGGACAAAGTGCATGAAGCTTTACCAGCACGTGCTAGAAGGTCTTTAATGCGCGCACACTCAAGGGTAGCCATCAGGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCCTCCGTTAAGCTCACGCATGAGTTCACGGGTAACACCACTGCTATGTTTAGTGTTCCAGTTTTCTTGAAAATCTTCATAAGGATCAGTGCCAAGCTCGTCGCCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCACCAGCTCCTTTATTACTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAGCACGTAAC ++ +2&&$$%%%,,.48:30)A>A>@;4=/6562.-2@HEAC:-(3(0,*,%&('(&'9;489<;A:C6=<??>ED2<D8>@>@=?@59?5758CD9IG??@?;@<D<;01-:1-,54/0.7-1)DLD?<826;8767*$,226-0,.%.4*&&,37598:7.-(2A72>120*,)/%%:67AB>B1?;@9;DDHHFGE@8@/.0;;<>B<8<44-'&A@?,8(539==>:=>77''85-*'%%&-/)$$)*0-=-:<42.',4;:8@:21-,A=9646>?;AFGGB>D>@<IGE@=2/456(-9<@GD;=/;<BDACFA@@<FEBD>@::?A879A??-7:1''446AA-*3ECF@+-1G3:CA>96>965?=>G:@6?<;BB:137)C*;?<54@AB?AFDAAA?@/'CBEICCBCRN;00-%907=9:2+,/,*)#&8;=?6A;:?>=*2*+A:;8'$*'0><AC??@=:IHAE?JFOBBI@98<?@2?>BBHJB@B35)*'**&;;2$(% +@SRR11410539.1391150 1391150/1 +TATCAGTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAAACGGAATCGACAGCACCTAGCCTCATAAAACTCAGATTCCAATACCTTGAGTGTTATCATTAAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTCTTATGTATTGTAAGTACAAATGAACATCAACATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACGAACAGTTCAATCATAAGTGTATAATCTGTTTTTGATGTCATCTACAAAACAGCCGGCCCCTAGGATTCTTGATGGATCTGGGTAAGGAAGGTACACATAATCATCACCCTGTTTAACTAGCATTGTATGTTGAGAGCAAAATTCATGAGGTCCTTTAGTAAAGGTCAGTCTCAGTCCAACATTTTGCTAGGTGCTGTCGATTCCGTTGTAGTCGTCCTGTTTTTAACAATATCTGTCTTTC ++ +%&''#$)'*(*,1,04<4/9A>910999<416,-.+7:564<9<95500*1078847)+*375706477,25-**-*3;38>@479.0.%#$%%'1.''150-((3=.7:1)+$#(*++-$%-0;984*2*4,013=<85?:>A@?;==8../((::2*#,%.057..//68=?A;:9/446//6CF77;CF=>@810,)))&2%%/2//26%(965525-482):;>*@>43/;'*:<)+7?93<52597:;*+'*)17800.''&24:552;0-)+$,'+&%%,)(0.2765'('$$'&('.''''),++('*+&)**.-,)'+&;;435BB@8:2+90'-5134&@:=?@;@&B<A@A@:;/+7123/0.10186229(5<AFA?@6746:9(-,3-.1::>C>94,+6((1)-,&6/+-*+-/3338863.5&&@>CB@EFTJ;:-6'4>308+'/21<>$)**.+'))487..2+,6551-)($%((+%(*%,,,,-# +@SRR11410539.1062869 1062869/1 +CTGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAAAATCGACAGCACCTAGCTCATAAACTCAGGTTCCCAACGCAGCAGTATCGTAGTAAGCATAACAGAATACATTGTCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTCTTATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTATTAGTGGGTAGCATCTATAGCTAAAGACACGAACCGTTCAATCATAAGAATTAGCATATCTGTTTTTACGATATCATCTACAAAACAGCCGGCCCCTGGATTCTTGATGGATCTGAATAAGGAAGGTACACATAATCATCACCCTGTTTAACTAGCATTGTATGTTGAGAGCAAAATTCATGAGGTCCTTTAGTAAGGTCAGTCCAACATTTTGCTAGGTACTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%&$'(120;>A;>FD=57?BDA=@B<A@B?673@IFBD.3**57?@>98576&0')065/51355:=A@2>+/%6$&26@>:956?>;>AB''&$&+&*$%#(1+%-,.>@A9@A?;891401(($&#)%./247C>>A@E66;=>B>72.,--7:8::(;+EIFC9;;5),BBGJC<,.8A4;:>FD=@K6.2<6/49-+3;21;7<A@??/1&AFEADE?:407,<0,0/7-<B>BBBCCGDAFI85GEE?==@AD<KDA97/9.0%&%$%#%%#%$'+,,10:;<:4%&01974<A@CFB@FGG<01-87568353-%)$%(&(/879455'''&$%989/<<>-@5;$8@-6=A?C3-9:779;9A@GAB@?:=;BCDB=??A?<88&<<9EE=G/DC4:??0B/0619;6=756'<7;/544?C@;=<<HA=@@;;6.(3<<7+.$$%29<IFH49796:9=A@ECBE77AAGJI??DCACHAB7-%, +@SRR11410539.2450744 2450744/1 +GTTGTACTTCACGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAGAATCGACGGGACCTTGTTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGTGTCATGCTACCTAGAGAAGCTGTTGAGCAATTTACCTTTACAGCTAGGTTTTCTACAGGTGTTAACCTAGTTGCTGTACCACAGGTTATGTTGATACACCCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAATCAATTTAAACACATCATACCACTTATGTACAAAGGTTTCCTTGGAATGTAGTGCGTATAAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTT ++ +&--'+)9:;3#:9?.6.<?@D9:=<;=9?8HJ&CRJIK=2-1->@=>4559:$+))'*.,.&*%*,))-1:>@BF>?>C?>?0.2,,-0@.BBEC=>?BB?,--/6?;B4D:6-/*@?<90KJ6@BI.&7&%12;AC=?E@>@D<80/=(40-9>??,8.0&'489>CE>EDCGB@-C*@<C>>AAOI>:A=:=?CIJF34D?:4=6;=ACA@96))'01A@>A>?@AB?BD=GD>EEDD?00<>DD@@JKKGD35G37(<<?BIAC0IL@A:=>@3CBA24$.=@?>>@>@A1:<95<><97)9=:=BA297);ED,76'(*8:@BEFD@;<;7@D?8=@168:/'*%%/+85699<>>758:8EEEBD;<//1EGKLH?CC;*<,D@(%*47-%@9DFI=<>;<DBBFEB6:<B9>++/89.:=@EE<;:D;>C>?7AEFEBKE=?BBMFEB?E>A24/.-619;=AAF>5. +@SRR11410539.487450 487450/1 +CAAAAATCAAGTACTTCGTTCAGTTACGTATTGCTAAGGTTCAAACAGACGACTACAAACGGAATCGACAGCACCTTAGATTACCAGAAGCAGCGTGCATAGCGGGGGTCAGCGGCATACACAAGTAATTCCTTAAAACTAAGTCTAGAGCTATGTAAAGTTTACATCCTGATTATGTACAACACCTAGCTCTCTGAAGTGAAGTATCCAGTTGAAACTACAAATGGAACACCATCAACAAATATTTTCTCACTAGTGGTCCAAAACTTGTAGTGGGAACACTGTAGAGAATAAAACATTAAAAGTTTGCACAATGCAGAATGCATCTGTCATCCCAGGATTAACACAATTTGGGTGGTATGTCTGATCCCAATATTTAAAATAACGGTCAAGAGTTTTAACCCCTCTTCCGTGAAGTCATATTTTAACAAATCCCACTTAATGTAAGGCTTTGTTAAGTCAGTGTCAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGCAGCATAGCAATACATGGC ++ +(''((&%(#$%&&%&(*3?36.,:=CE?97794;243(1((28:(.92;6=;>><;?<1<ADD4(*><'7$+*0002/6/102-8.-66*9/.99FCD@/<+6$(,,.*%%%,$.<?:=D=:8/01568920))++)*)*,-/+;0707@CAI:<;7839==9::?&&+6CFNA:;D55>9<@>51*+3;9;<277512,5($'0:/0A02A30+-,.2><A@75<=A<=3*)'&,-.5>?=;<C@QHCDGD@:B380132:>?;867:6+'3B64,6==7320+'&))&(0797(0,%'35967>AK:;9;BE=8;@8:9*(,+,27;997--:*9(1-IGCE?GDDC9=7011.047B=7.;*))349:CE@B??FADCKB@@C:<6@;</);9>KF=<573))=FB9=<1@.<B>DGIIECC>+*<:;?99>>8**+?AAA?:;6,#(-EDCB*+++>5=@67;77:/18=579<66<;;<<8::AB95.0011'((*+010$'*&-(@??=8/&&/$,'%% +@SRR11410539.299203 299203/1 +CGGTGTGCTTCGTTCGGTTACGTATTGCTGAGTTAAACAGACGACTACTAAAACGGAATCGACAGCACCTCGGTAAAGAGCTGGTGACCTAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAAACTTGGCACCTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAATAACTTCTGTGGCCCTGTTAAGTACACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTGCATGCACTTTGTCCAGCAACTGGACTTTATTGACAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCCCGGTACACGGAACGTTCTGAAAAAGAGCTATGAATTGCAGACACCTTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'$%%%&%-//146/&$)'+,1.-.00)/,&'7/.%)'1.4025.-.(#%0461;,0,<820)+*%(%568=(-(&$')&763)+'&%*)$&'%2/@3;EBDCEB;=6>?769@?DDCFFCJD>AB@<6+%'*%---&-D=9&877//6/28:44)5:C=59=::.01?E>B>BE=B@:;EIFBB>?=738703>-17:AC@8*2.6>A>87688831??@?214;=AE<2BAA:>E78<;;==4,05534<873+*$+)'-014--./6688.'+#$%($$8AB@BA<39/5?@CFGHIK84A;?1.;-+5'**(27<A79824/'(1+-111001:;53../$%,34>C@CD@K?97253,(),002<8<A><<I@<=<=?>ECBFHFBBBAHC:A9;7,6*'''*2:-3$'@CC?F@PH?@B@J3,&*$*$/66:324;:@9:*8<;=<=;;BBCEB@=C;:KE;=;BD?9:64;>>BEABAG?:4577877>??CB.1&,% +@SRR11410539.1457199 1457199/1 +CGATAACTTCGTTCGGTTGCATTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTCGCTTCCAAGAAAAGGACGAAGATGACAGATTTAATTGGTTGCTTACTTTGTAGTTAAGGACACGCTCTCTAACTACCAGCATGAAGAAACAATTTATAATTTCATAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTTAAACTTAGAATAGACGGTGACAGCAATTTACCACATATATCAATGCAACGTCTTACTAAACCTATTAGCAGACCTCGTCTATGCTTTAAGGCAATTTTGATGAAGAGTAATTGTGACATTAAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAGGACTGGTATGATTTGCTTAGAAACCCAGATATATTACGCGTACGCCAACCCGCGCGATTGAACGTGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCTTAGCAATACGTAAC ++ +%$#%$$#&*(79*=,3;=++&%**,,&)1..4>=;><1*-,(&$&)$&*/03$*$09??:2/0:8>?CE>993468*/*,-965&':A:118:FHBD04,,AD<;<<>,.6@/6;><99950103>>//%)')&&#%315<:DA<D@A.A&>25>3@1>BB?GGBGH<B=?<91%$0./.*';B?++9:22=935$.6CE<>61('#$*$%%%%&(.567A@CJ>@>EB-213+**$$$$$'%(*0%:453-,.,'*(&.+,79<<>612&&(%$&*1))$&'&--77A;42:3@=?=DD7&((.0%5/499<;4$$)'%*645355;:7(=?8GHN8$(;=@9:79:.154:732312120DE4B00=99===?A:FE?E@C<GKP1'80*>05B?DGCCA1(&(*11=;B>B<;<DBA>>:<8=<363-8566,,/($$&('($$-6.:>:?@:+>?53E502<''(.1=III?9=?<A?;:((;?0?*55566->@810B<:4,% +@SRR11410539.394448 394448/1 +GTTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAGCAGACGACCTAAACGGAATCGACAGCACCTAATTTCGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGATTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAGCCATCTCATTGCTGGTTCTATAAAGATTGGTCCTATTCTGGACCCAATCTACAACTAGGTATAAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAAAGACAACATTAACCTCCACACGCAAGTTGTGAGGTGCTGTCGGTCCGTTTGTAGTCATCTGTTTAACCTTAGCAACTCTGGC ++ +%77%(',/--181:%*:=@C?CC=@ACA-*.8EC78*0,,1.6,5.22325(+*::;>G9D5>?CEF9:991$48<E2;98?A7959.4397'.38764<.+74&('(',D6JGBFDID??AFG>AAC>>F;HA5398?CIJC>FEAC<84?=<B???AB37$5;@>@GFE?EDALG?MFG=BFHEB??>EFBB74-C>EFG;104<@@)==A9;7,#'('':6:?+6)958:&244;>?'')BC@4*2(.9$88339>-&878<;A7497.%(3BBKAI?01>956;<F<<:@AFA?GCEJHG@?==8(9>5>9:**/>9:;@G5><-09=6>@BBB83,*&#.=>875@>CDFC@ECGB873@()<94<>@?7@=F;KHFFD89++*8@8.B>8:>899453389?:;:=43-'&&&&++22./89;=9:<=A68(3'(1566;97-0;2*?@??@>8;,*227;?=8'*,-,--,+12B?400,1,)&&)$&3.32*++ +@SRR11410539.2010016 2010016/1 +CATTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTGAAGTTCTTTTCTTGTGCAGGGACATAAGTCACATGCAAGAAGATACACCATGAGGTGCTGACTGAGAAAGGACATAAGATGATAGCCCTTTCCACAAAAATCAACTCTTTTTGATTGTCCAAGTACACACTCTGACATTTTAGTAGCAGCAAGATTAGTAGAAGCTCTGGTTTCTGCAGCTCTAATTAATTGGTGAGTCACATATGTCCTGCAAACTTTGAAGTCTGCCTGTGATCAACCTATCAATTTGCCCTTCAGCCTCAACTGTCAAGACGTGAGGATATCATTTAAAACACTTGAAATTGCACCAAGTGGAGCTAAGTTGTTTTAACAATATGTTTAAAGCTTGTGCATTTTGGTTTGACCACATCTTGAAGTTTTCCAAGTGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTATAACAA ++ +,%%&$%$&2323?.*%9=<8.200/4=CE@@4CGC?C4>9:;672::77::*0'*'698>@>:GGFCBG@ACA9ABB999A:?DD4E;:38>@=@/6013?B?:*%*71242.1+%)+04635734CB??HGI>;<'%(4&'?H>DAADFD;%%23??@@DDF,.5:HH=@;5B67?A;KFQLA>AED=78>767@C*BCFD0A5@?<A@=N>7BAF;;:4512)&&($'%1.,)7909,%(*:779;86:12>/02/2,,*3&&1%$;:<>9??@<9&&-())463-=A=99+8<><>74//7;96?47;77.,4-/-.<7-8**62-79717&&(2><?9;:0+-/''&<9939@@BGCELB>75)),/1324502++A88'<,1*-27..12524>A778:4)$08<CC:AC>DBCB0G@B@??D:()*/1;-@C=?>?@A=9-;9=BYI:>;<9MIDBCF;412<=BADFC;;;EDIBA@A:<75:?<??B=:6&.$&&**% +@SRR11410539.419511 419511/1 +GTTGTACTTCGTTCAGTTACGTATTACTAGGTTAAACAGACATTTACAAACGGAATCGACAGCACCTGGAATTTGGTGCCACTTCGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAAATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAGGTAAAACCAGCAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAAGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAGCA ++ +%23.0/;<A:?I24-:>AH?@ED>.%4-(*8FDGH@7393>/018/9?A??;=>A=A@@60ECECBHAB@>;;?;=>ADE7643%$%1/47<B97/-?=DDEF432339700).*),'$$$)+,1462@?321172/::B))9EFAAFFDEBB>A33ADEB?C8@7050/-0>F>A5/;-->;%%=?C@EIGFFDFB6>@BD;?78-*<?BF9:?@2?9;729),?;:<.52F@=7CABDDEFB?9;:9>?6>./=059EHGD><CEAC86:A8:KEAA@>BE0?:;:778<88BE;;@=;=:77:CBBCF9;A<<EABHK=D?BEB924258DF4&1-156@=9-B$:5=;;?JH;A;''BB;7?B@EA=?IFC:8<9?GG=B?<025)*')8A=BA621>4)4AAAABA2*<>BC@D=?C55@AC--86>>=>8:5?A>:5)>0BBFEDCA-D=BDB<?:1-5?@@D@DB?::9=9<?@4:==<<@DE4@'3;<=AA9+6$%% +@SRR11410539.1036694 1036694/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACTTGACTACAAACAGAATCGACAGCACCTTAACATGTTGTGCCAGCCACCATAAATTTGCTTGTTCCAATTACTACACAGTAGCTCCCTCCTAGTGACTATTGATTTCAATAATTTTTGATGAAACTGTCTATTGGTCATAGTACTACAGATAGAGACACCAGCTACGGTGCGAGCTCTATTCTTTGCACTAATGGCATACTTAAGATTCATTTGAGTTATAGTAGGGATGACATTACGTTTTGTATATGCGAAAAGAAGTGCATCTTGATCCTCATAACTCGACAGATCATAATAAAGTCTAGCCTTACCCCATTTATTAAATGGAAAACCAGCTGATTTGTCTAGGTTGTTGACGATGACTTGGTTAGCATTAATACAGCCACCATCGTAACAATCAAAGTACTTATCAACAGATTGCTGTCGATTCCGTTCTGTTTAACCTTAGCAATACGTAG ++ +&$#$'.'68956BC;6<<4)62<;8:98>32.BD@DIE8//-(,-:6;6:66720*.)16:;9<:@@@DCCC>AA>''<90<,,,:*9;E@>A>%*9>>=97:?<?=/5&'&(%(,./75333,*;:597:&'972*,%$(+*-75:J<A..5///1...<?<:;E:7?>:;?88>089AA>24G:;HA=,,=/;+<?>ADE@G=@@?F?>76(0%'110=<<=@F?>?CFAHMRC>BEC99221*,335;A@?A@=9B@BHAE@3?/5>ADBB>88949;LGPJEDFEHBD?00C6&$$$1<565)07:A;6;>A><=60,./$$'),57<7BBECEH947<+3)('&'*4445<BCNJLICFJEBE<=9;398;10;:;HJ;79<:=BJI<A;666<?GKGFMC36<24+3:9@<><816,=?ABCGBIEC?BGA0'7AB48<<;;><9<23658((2?ACA;>@>BB6711%+3213*//36253-'99876<6.$ +@SRR11410539.1262957 1262957/1 +GTGTACTTCGTTCAGTTACGGCGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTGAAGTTTTTCTTGTTGCAGGGACATAAGTCACATGCAGAAGACTACACCATGAGGTGCTGACTGAGAAGGACATAAGATGATAGCCCTTTCCACAAAAATCAACTCTTTGATTGTCCAAGTACACACTCTGACATTTAGTAGCAGCAAGATTAGCAAGCTCTGATTTCTGCAGCTCTAATTAATTGTTGGAGTCACATATGTCTGCAAACTTTGAAGTCTGCCTGTGATCAACCTATCAATTTGCGCCTTCAGCCTCAACTTTGTCAAGACGTGAAAGGATATCATTTAAAACACTTGAAATTGCACCAAAATTGGAGCTAAGTTGTTTAACAAGCGTGTTTAAAGCTTGTGCATTTTGGTTGACCACATCTTGAAGTTTTCCAAGTGCAGGTGCAATCGATTCCGTTTGTAGTCGTCTGTTAACCTTAACAATGCTCAACA ++ +%(+/-7=@<448@<>96.-%')(',((,@@@AD3>:<>>=>76?945.4*/-4<<@=997:;;;=:12-+5,*-3=>A>7$&:3.AAAAA;7&'&:AA:4=;)7&)(124-;;@5?913.:9?CC>A=;;;7$38%:@=A;AC?>>67=9?DCCCEE9;-352=<2+;12>B:JH<955:866@47.?E.2=.'*<<C?>B=><86AJ=AB=DFC6EJGA@@,--B=8>A?BEG;FBCDDF9@<576502/2>DB-/5:4C><?<==>9B=9ABB,(;B?>@9?;=C@??GC>762B01:8B=69:=:==(*$%%)4>@=?=<B::00<I0*<68C@=7>B?D+?>CC?<@<@>C@AFC<3*),20(7:C><65>574219;=0:?6EGF@A?BEB77:<G@>=47;@?DEB><=>9E07::?@8.17?@=>==<.+/*)#&%#,--0&*775J>:>598.++)--6/02597<>F:@FC::314133/()$)$('&)''$#"#%%$%$ +@SRR11410539.1480000 1480000/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAAACTGGAATCGACAGCACCTACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAAACAATTTCAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTGATACCTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGGACACGATATCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCGGCGATCATCAGCACATCTAGGTTTTGTCGGGTGTGACCGAGGTAAGATGGAGGCCTTGTCCTGGTTCAACGGAAAACACACGATCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTGCGTGGCTTTGGAACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGAGGTGCTGTCGTTCCGTTTGTAGTCGTCTGTTTAT ++ +,3420/'&*--3//)7A??:7777914>56-<?@FIE=>B>C9:037649=623367C>=8A<@=@BDBFFEA12++/077<:9545?6><<4300((,,%32,/.16976..0011$*)-07;11/,918<<17A>?-::@?ED?21&%&&)%'$$''82;3272<8:898945=898<DFEE<=?</07;>F=/):,+3*()((-.8<-'=,:=?LBF</415C>?=:AACC:=FF??A67>@E8-07B(/5**1>5326)69A?<?615@CEFC0(A03=5*=>=:5.,+8:;BBC?;64-6$+$$'%%'/'/47>21/'%.7547%-/2()0>67?71*=49KAGFD=B?>80/(@;JGD7765;5C==C8.<(83E8;556968(+:@1;>GAAC>:0,><>D777<7;0=AE;>;7F67>77930GJ;15<41)4<6;:5(%$,;38:EEH15654:+*22266-&$ +@SRR11410539.2321235 2321235/1 +CGATGTACTTCGTTCTGGTGCACGGCCTGGGACGAAACAGACGACTACAAACGGAATCGACAGCACCTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTTGTTAAATAAAGAAATGTATCTAAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATATAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGGAAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGAGGCCCGCAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACAGCAGCCT ++ +'$$#$(,((,1:@43*$%,$%#$#&%$##%%$##'4'87::?==6389FF<?24>0+5964989>?>GA:<DQC@>F=I>2EKFBB@<<A5--...7KGGIEHHBE8@;<+1:5><;>B=A@FIB45=FB?@9:1<5-8&:5;DCB;2:=A@@BCEBABCFD?=>974-++*04%*89><GDCDACD?;6=223ACE@D=75;==>0?BGECD?BG<@A?9>7:>??EC/8?8>;=98<>>IJE:>=9A>>19BC+8@?@D:B8:;>=@MB>9=9$$5406-AC?D@CACAE?ADDB=HB;:>?E?4><;>7<<:E=;9=388)64/321*+***&&/0$)+<=>DEJ@//AF<<DI<>F??=>@A??C*.4=7?366=9/%&>GF7*-?77634123ABA>BE5'6%/,//0,1++355>>9:>BCI<>89CED>C@EFB@8?3:?><CHAB>88811:22(+9:@?C<<:9.2(+$$'FB?J;5=:=?>@@AGAA:>:8804332(0&&%0&$%& +@SRR11410539.1662695 1662695/1 +CAGCTACTTCGTTCGGTTACATTATTGCTAAGGTTAAACAGACGACGCTACAAACGGAGATCGACAGCACCTTGAAATGGTGAATTGCCCTCGTATGTTCCAGAAGAGCAAGGTTCTTTTTAAAAGTACTGTTGTACCCTCTAACACACTCTTGGTAATGATAAAGCTCACAAGTAGCAGGAAATTGTTATCAGTGCCAGAAAAGAATAATTTTCATGTTCGTTTAATCAATCTCCATTGGTTGCTCTTCATCTAGTGAGGAATATTTATTCTCAGTTAGTGACTTAGATAAATTTTTAATTATGAGGTTTATGATGTATCAAAGATTCCAAATGGGGAAACTTTAAAAGTCCTCATAATAATTAGTAATATCTCTGCTATAGTAACCTGAAAGTCGAGATGAAGCATCTGTTGTCACTTACTGTACAAGCAAAAAAACAATATTGTCACTGCTACTGGAATGGTCTGTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +0$$#$%*/325H<9%+)/.0$$*158666+,=AHB=@4<67@<A<4/5:%)573<**+$&+)*'*5-<?;@@<@ABJC=@;=6438/2130:90<<CFB1754/)+2-9,,;CC?..9974CGB),=21?A:8''&.2)0:32/,<:995579132--378:=@24<=6%&%'(),&&%%%&%%%29:=<7@:@B@</?+?29&2)&(./..EB38>AB@<>IGD?<6B8:866;=<<:5859335:B@;;;?2;&C?>3&12//:80689?<5-;>=23??8.232335/1/0.'''(*).2677:@HH43:<@=7)+%233(5;AE:>====6,$$46449><FJ9)*889;=9622/788;51,7:??9=1<ACDI><==<AC;;;<<51,*(,+6>9C35%>?>CFBCE;682236==AA=:;==44><-&$&&78=BABD,(D((D=B?C=?ABB??5=6::9@B93;4BBBD?;?>>>=>?=ECFBECB:><;<4<:9A?@8<88>1:55>BDB=''#( +@SRR11410539.1822939 1822939/1 +CAAGACGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTTATCACCCGCGAAGAAATACATAAGACATGTACGTGCATGGTTGGCTTCGATGTCAGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCCTTTACAGCTAGGTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATATTGCAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCACATACCACTTATGTACAAAGGACTTCCTTGGAGTGCTTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACGGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGGTGCTGTCGATTCCGTTTAGCAGTCGTCTGTTTAACCTTAACTTATTACGTAAC ++ +.%%$$#%&')%.-41/2;??9:<FEB281++3@NJHMI;::8;<==@7::=&5&),74/+/5639<:967;@FFFAE>IHF>./).*213310+3778BBFBGA?>EHFB3=&,$)/668AE>>J<43%):99;9:9:6A<7937%%%.;>,8:16:6776955.&3567;>7-1&1,;CB79K59CB>=?C>DEA:;;>.)<+1::5>??<=8==<;>98<=<?00%.54:::@4523-.'7*?@HHE@?(-G/>H@<+1C>A9LOGE;4++$:9C===:/%;9817;CE@<A6618*-049:<B?DDD=ACICA@%@A-&>.57>=,--$&&&&)%'9641<?8CE-4?>A=BH<@DFAD@C?A?HGF;-.49;;FL>E?;=??9>88-+&,474<=B@KD?@DGHEDECAB:EG;BBMJEEADD@DA>28=:<1-648@>?BKK@?=<1AF:9=A8/1//06A;=?<;:228B<=>?:=DCA:>7@<>,48344022&'065&%%%&&467:<>C==@CGD.BC''&''4')-;;6*4* +@SRR11410539.1352976 1352976/1 +CAGTGTGCTGTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCACGTTCACCTAAGTTGGCGTATACGCGTAATATATCTGGGTTTTCAAAATCATACCAGTCCTTTTATTGAAATAATCATCATCACAACAATTGTATGTGACAAGTATTTCTTTTAATGTGTCACAATTACCTTCATCAAAATGCCTTAAAGCATAGACGAGGTCTGCCATTGTGTATTTAGTAAGACGTTGACGTGATATATGTGGTACCATATCTAACGTCTATTCTAAACTTAAAGTCATGTTTAGCAACAGCTGGACAATCCTTAAGTAAATTATAAATTGTTTCTTCATGTTGGTAGTTAGAAAAGTGTGTCCTCTTAACTACAAAGTAAGAATCAATTAAGTGATATCTTCGTCCTTTTCTTGGAAGCGACCATAAGCGCGTGTGTCGATTCCGTTTGTAGTCGTCTCAACCTTAGCAATACGTAACT ++ +($&%%+$%*'7:5;498=;5-96344:8483DQIEG:)%*%1,'&/*.22%&024:=?ACDIBIDD>F?CCCNICGIF>9:=GE<>ECCEDD@:5:;8;B??@>A?<:FH?50&$'9A=?756>=>?9:?@@KG>>B7:GECED=8E?@@=C<<33>CDC@B?C>>CDG:=>760;>@=FBGC>@>A:<;>;9CCBCDBAKHEA;>GHGJ<>A>DCGIB;:C:779767B?7=?><?;=;+=124<<;*,:9;8(56<;7272A54474435-+/1+,,*&)--)$$%(48967:?9>?1///66&&;<2+.9<8A0C770<)>9?A@8;>67?<=123:=@??D4D>@@AE<??D:EC<B?DE?122./@:C39-4376999((/+9A@>><>A?@BB9FCA+70'+)*)-34$9640:9;=8::56:5:=AAN@<A<?@:9:,+'(%&*##&(&(&88<@ACDDE?GAE>=;94=2-.)&&'(+(0=38>>AF@<:,*#% +@SRR11410539.1345613 1345613/1 +CATTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTCCGCAGATTCCAACGGTACTAATACCGTTGAAGAGCTTAAAAAAGCTCCTTGAACAATGGAACCTAGTAATGGTTTCTCTTCATACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTGTATATAATTAAGTTAATTTTCCTTTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAGTGGATCACCAGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGTTCAGTGTGGTCATTCAATCCAGAGCTAACATTCTTCTCCGGCGTTGCCACTCCATGGCACTATTCTGACCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCGGCGACGCCGCCGCGAAAAGT ++ 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTGTATGAAAATGCCTTTTACCTTTGCTATGGGTATTATTGCTATGTCTGCTTTGCAATGATGTTTGTAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTTGGATATGGTTGATACTAGTTTGTCTGGTTTAAGCTAAAAGACTGTGTTATGTATGCATCGGCTGGCGTGTTACTAATCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGTGTGGACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGAAAGCCTTAGCAATACGTAAC ++ 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+CGTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACAAAATCGACAGCACCACACCACTGGTTGTTACTCTACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTGTATGAAAATGCCTTTTACCTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAAACATAAGCATGCATTTCTCTGTTTGTTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACCAAC ++ 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+-*$'%%%0023=EA/3<7GFGBCFDAA:?4++7@@520&$1>?>@?=9;73)+'/9:<?:%*6@@;CDD;A74.*'&,0/4=1<-;.&9<<@9:C@A9;4((4;=C:2&0$-(>>2%)()%'77?<9331043B>:<??B@C=D<66;9;9>@@BE6;=;AHIBD;44><=?94E6A@8:@A><<&&'9:A:96C<>DF.7+*,460<734($%&*$)8<C=<8;;..**0--;=>G?BB=B:ADFDCE=;A?=?77.+-.''%$%$&'23234;A85/75/75AB:77$7<:<B=58(343453)()&&'46486A:95,0<?>996CB<>9::2-$-$$,77AA?12&-04A@:;:544%79;99-169;572278<H>D@=)579@77;.-649:<8<3159>>@EMK@=18'73&&+%>=><>=7204))/..447'8@=@=10($&'+&2633/$/-0//(6==<=EACAG>GFCB@>ECGFE=?=DBIAB>=9<::=>@===>>DDD8>+678<=ACF>6)* +@SRR11410539.1116391 1116391/1 +TGATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGGTCAGAATAGTGCCATGGGTGGCACGTTGAGAAAAGTATTGAAAGTTTCTGGATTGAATGACCACATGGAACGCAGCCACGCGCAAACAGTCTGAAAGAAGCAATGAAGTAGCTGAGCCACATCAAGCCTACAAGTTAAGCCATTGCGATGATAACAATTCACCGATGATCAATTTATTCTGTAAACAGCAGCAAGCACAAAACAAGCTAAAGTTACTGGCCATAACAGCCAAAGGAAAATTAACTTAATTATATACAAAAACCTATTCCTGTTGGCATAGGCAAATTTGTAGAAGACAAATCCATGTAGGAATAGGAAACCTATTACTAGGTTCCATTGTTCAAGGAGCTTTTTAAGCTCTTCAACGGTAATAGTACCGTTGGAATCTGCCATCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&,*$&(%.46:BD18488?FB<8754*7;001028>>.,(1'.'(;??AHIAA/2./4:5:06+-*--,.)+,2@9<G?@@G>??66&-3:/59:<<>=A;'7<0'&(&-*$&$$*6@@B=592D>:9>422?>(-(+-.145*+*'--+000177:<>91+9079C62E=5E:;>>?=69A7=@?3:;7*.40D<>???62994,+-464D@34>AE>FG983'(38::)*'(('%879:C78791,,3B>>DFG9,*/49)4<=6;:?EF?>@??(89>>8:=CB>@.18;?DBD74FB?DC/.:*0:<9:*+''(%'%*60:9:@II;E<><DCEK79:1GG5<B<401+:7777-2-2)(310CB@A<;<A=62)*(%(%$$*+)-1:970007..51?FE<?=BDBG>@DF3>/9CFEGE9>@BFC@NJC//>$*=<@1A.><DA=CD?BDC<C@;=<.)$$((?:8<<;@EDLHBE:CDL?<<<;<76>15;4/079886=/:;:878+;=9-- +@SRR11410539.1996412 1996412/1 +CGGTATGCTGGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAACACCTTGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATACTTGAGGGTTATATACATTTTGGTGCTAGTTCTGATAAAGGAGTTGCACCAGGCTGGCTGTTTTAAGGCAGTGGTTGCCTACGGGTACGCTCTTGTCGATTCGAATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAACTAATAAATGGGATCTCATTATTAGAGTGATATCTTTGACCCTAAGACTAAAAATGTTACAAAGAAAATGACTCTCTAAAGAGGGTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAAGCTCTTGGAGGTTCCGTGGCTATAAAGAAGGTGTGTCCAAGCGATTCCGTTTGTAGTCTGTTTAACGCAGCAATACGTAACT ++ +,&+('#%&,$&/(>-1<=;2+<67;)%&45&=>9:>64031A?B=AGD@B7<5:1A:23&%&&'-1148?85%&448>;2,%$+:88>?>=2,>;;DDIGADHH<?IJNJEC;&&(434@?:40%$2=;91))%%')($$+'0,*)&&228;A1&(.('&$*663.?>>:;+.4&6,249.%+'('&%#&(,)'(()$&&&1/1>67KGB=BB<=144144('-&&>=8466C:4++/57C>;=AD@3BCE?=?HA?GDD9(/)3A7:71*,-/@@CH6:?ABCE?GGD9:;DCC624(5;015:@C<DGD<9<>A=?FA===67/0&%+/++)'++0.)57:<889;<:44EKKIL?@AB6><<%2CGCIBF?D><'&;HK2'6?G@OLTED<;FJGFFGGJ6A><ADFE<3571+'?@:6*(+'',>=C@?.531A<;6;@E?A@>B9FJ8&.'0*-')%$$)#$%%++(+>?9>?;0.+))5*''()%%&$$)&778:/510.-&' +@SRR11410539.127831 127831/1 +GTTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGGATCGACAGCACCTAAGGTGTCTGCAATTCATAGCTCTTTCAGAACGTTCCGTGTACCAAGCAATTTCATGCTCATGTTCACGGCAGCAGTACTACACCCCCTCTTAGTGTCAATAAAGTCAGTTGTTCGGACAAAGTGCATGAAGCTTTACCAGCACGATGCTAGAAGGTCTTTAATGCACTCAAGAGGGTAGCCATCAGGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCTCCGTTAAGCTCACGCATGAGTTCACGGGTAACACCACTGCTATGTTTAGTGTTCCAGTTTTCTTGAAAATCTTCATAAGGATCAGTGCCAAGCTCGTCGCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTGTGGCCCACCAGCTCCTTTATTACCAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +&''%%$4564<A*;,-7=?8;8813*65-.6GB@@C@78;8;?<89=9<;.+$&,3:@AC75@CBE<>?>7<BF?AF7<02.:58-5+9<ADB=<08?>?98838A=DEC>A591ACCCEGC==?FJBB?@DA;);77)*&.(+)&&-,55?>32087A;13DA=D566GH:.$;22@B?D<?=A@;<>;EHIG:5>/,8;;<;A<;575+.%%,%'/6-<6+D@AFA93445969=@34A/82A<9;=<=89;211?794<279B?B969;8:52'-+(*)%$.4)'-03@A=<9><BAAB@@A>=:>>946-<<=:27344158??=;592+$-?>@KMA@:A>??4;;?;<EDDCFCC;D?8:@B;57027<718/9DBIGBC1>??;>C;8(/0?;BABF;CB67;%&/<5B<<?444220.+*%&%%#&&(/29=>619.==659;A2%.=@AHB<A9:CA<><GCC-768=@<AD7??=E>?@@CFG??FD<=>;:30% +@SRR11410539.1916943 1916943/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTGTCCACACTCTCCTAACACCATCATCATGCACAGTTCTTGCTGTCATAAGGATTAGTAACACTACAGCTGATGCATACATAACACAGTCTTTTAGCTTAAAAACCAGACAAACTAGTATCAACCATATCCAACCATGTCATAATACGCATCACTGGCTAGCGGCATATAGACCATATTAAAATAAGCTACAGTGGCAAAGAGAAGGTAACAAAAACAAACAAATGCATGCTTATGTTTGACAAACATCGTGCAAAAGCAGACACATAACAATAATACCCATAGCAAAAGGTAAAAAGGCATTTCATACAAAAAAAAGAACAAAGACCATTGAGTACTCTGGACTAAAACTAAAAGTGAAGTCAAAATTGTGAGTAACAACCAGTGGTGTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACAG ++ +$%()015-.10:B.=77D@.5.;323%0=-.:=AAEF9A11=8;<87((%'%(*%+346?>@EHE>=G>:;C9@EGB;>$)@22@;>>=2'#053'&,4@>@D5>4;53AC>B<<AB0??F9@5;<>>?98B:95?7<??3:07=A2544440.;5::750#'%&'BC>?>:::7@/CD8/1.5;94@8;?A>59&&?//<:=@96@4577<B=4;>9B(($##%(&$$&2<6AA6675=?AGGIDDE:G>23<B>EDFBJHHB==)-1/''&'6675EFEJF>HIC;$(6*+@<//00@D>A>=IBC>GEB:C:-%A58GG>475441/%')&'(165989>?CAF=:@:>IE7((:7BHE3(.3?5<>C?;449FGJE4+'$)@>;CG<?8<777:==>A<>5>46:.'3?AB544DHH<7(5%2<<???6102&<:9<?;;9''$$&(6..=851258,=4'''&('&,-56399:''13:<==?9=<@FDE@BB.6$'%&&&(#& +@SRR11410539.795351 795351/1 +CAATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTTGTGTTGTTCTTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACCTTCACAACTAATGGTGACTTTTGCATTTCTTACCTAGAGTTTTAGTGCAGTTGGTAACATCTGGTACACCATCAAAACATAGAGTACACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATGATACGTAAC ++ +-%&'')):>B<9C961>A@474B?18@A:AC&7?D:<2-64:B<EEJD<GIEA>@DB;:8<@GEGFC7B>9=>;CE33$>*259A>=C=FIBBHEEACDDNEACAGACBE@>96DEDH?ED:8>:9>?CB9:>@BAB741'.889;877(/%)'7:@>;5=@A@CCAF@;$'5=@??:?B?778?46@4.>.-:=7FFE=A=<;<18A=<5<6B;5,,.=@:IG@@KBA;<>B<ACECB@>=GGDD?A<B;:;=:=;?8;<GA@<?>?@(+2847565?=753>>?:ED:>8885BCH>BC<;BD5*+,.*+0/%058?=>153654::;@HCJ@?=86EA=<:,08:C?CCA;22<?=@9;59)''$$$0656*===>+0DA>8CDCC9@A?=DBCC<D@C<>/:05M=45>:3-/>=35222GA=?93%33)=>>85<??62(5)3'%02*%;=/>'4BAAAD=ADGIE8923?F73074416<<<9;>=>8<8;(($#&%&651*0' +@SRR11410539.1463754 1463754/1 +TGATAGCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAATAACGGTTGAGTTTTAACCTCTCTTCCGTGAAGTCATATTTTAACAAATCCCATAATGTAAGGCTTTGTTAAGTCAGTGTCAACATGTGACTCTGCAGTTAAGCCCTGGTCAAGGTTGACTATGAGCATTAACAATGAATAATAAGAATCACAACAGGAACTCCACTACCTGGCGTGGTTGTAGCAAATCACCAGAATCATACCAGTTACCATTGAGATCTTGATTATCTAATGTCAGTACACCAATAATGCAAGCATTTCGCATGGCATCACAGAATTGTACTGTTTTTAACCAGCTTGGCGTACGTTCACTAGTTATTTGTGTCACATAGCGTAATATCATCTGGGTTTTTCTACAAAATCCCTTAAGATCCTAGGTCATGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTCTTAATAC ++ +%-(&(#(*6+59>FD@=78778+>8<<->HHDG>?;=9.6+/5+4682+138=;9=AC9883@:B>>7$$'#&,+$%%/8C@>A;:=3;@CC<A:1:+(-64444;5219>@DED78?@&7;?999;<:<6;<:.%)4668;36972@:;7;:6CHGCD;;2)%)#)/0,982,;=<>78,:4+$*$%&'%$'.,+,<>==?6:0@CAC>()$$+%,..2145=B=>=A7>4476554,,%&%*.-/))(%%'.+%2'#$##&(&'+)0357?<7-:8''+79>?<>?@BA@G;6?7..520>57?5;/'-*)*$3)(1&&(/0:<BEACA2<CJB<946:3446<6;5:8$<>C>7&&$%$$110-/*0)'*'3+4+.*')4)&''((*(%/,.%%$(')+,-,,$$+1=580@DBCB;*/++018<''5&&)#%+$((++,(**'*()--75GE:<6?>C=9<9;>657)+65-.,$&&*$$%'&%%& +@SRR11410539.276914 276914/1 +GTTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGGAGCTAAGTTGTTTAACAAGCGTGTTTAAAAGCTTGTGCATTTTGATTGACCACATCTTGAAGTTTTCCAAGTGCACTTGCTGTGGAAGAAAGTGAGTCTTGAATTTTGCCAATAGCACTATTAAATTGGTTGGCAATCAATTTTTGGTTCTCATAGAGAACATTCGTGTAACTCCAATACCGGTAAACCTATAAGCCATTTGCATAGCAAATGGTATTTGCTAATAAAGCACCTGCACCAAAGGTCCAACCAGAAGTGATTGTACCCGCTAACAGTGCAGAAGTGTATTGAGCAATCATTTCATCTGTGAGCAAAGGTGGCAAAGCAGTAAGGCCGTTAAACTTTTGTGCACAAATGAGGTCTCTAGCAGCAAT ++ +%*-.<>A?>F.81:@@::8:<;;<?A?<)>F<F@$8;:>5?A=DKDIJC>*/DA<=<D;H@GH;=88<?B<??89<?B9FDB==83,*;:FA?ACABA9///2+9675???2%$387??BBD@>CHA006BGGL827<=7D920:ACC@>:=>B9D-+))+344;8@>A??<QTSM><=EDBH>?FHEF>>CA:<DACNKBBBG:2C:A:=NF=/4BBCFEC:85/83=@776'%$%*25A:%@CDA<;8%&?9:F@AIDECE8HFBFHPEFADABBEGE?232<==G78>983()'128;<EBC=<BBA%2;34ADC<9>3?A4CC@EF8/278435<@FD<D@8+(%((2EE=89:46:<BD?BBJKEF>;??>8>0//34&-.6'16453&,,-323.3578JHFH9>??GA8FA<4>??86'+090/+:+3/*8',3/& +@SRR11410539.491996 491996/1 +TGTTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCATTAGCACCTACTACCGAAGTTGTAGGAACATTATGTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTAGCATAGACAATTCTAGTCTTACTATTAAGAGAAACCCTAATGAATTTATCTGAGTATTAGGTTTGAAAACCCTTAACTACTCATGGTTTAGCTGCTGTTAATAGTGTCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAATAAAAGTTGTTAGTACAACTACTAACATGGATTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAGGAATACTGTAAATAACTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGTAGC ++ +$'&(%&&+..17H/+$:.57B=DA@@;;977/554-12;:::;;;;6<;?B<=9;<=0)&$%(1319970;?:GA:6166?895BC*,.%099''==A6JEGF@DEFEGK?:@?A@ISD;87:12,/;.*04A?@7772.34120=7@9=@E@B=@:***$$#&&023A>><4>2=A<>EE:3=BCB5585+/DHCDC?%%*$%$,18/*7$$$'2526769II=9;?>822++-%%,4::C<DD>@CE<5:?A2@A?>B=<21/?;88A;<;AD;2+,-&-.88=?B@B><<9=.;,<=CHL66,1,,/=A;047?1BC;=LI?8823.;:78=>@$*$772+7:,39;:7.16+;;98<CD>+)650=?9=;==78BC?<068B;CA>6@GKC;;A<9=0100.1/,79<==1(-*:+3'*=4===<7AC.>%;9+,563+414C<911:65D<??B@-,,'(%&&$..**01-.$%&&$$%'&21:;?D577GHN66779:7:;1,,,++)&(%'('(''&%%$$$ +@SRR11410539.1795528 1795528/1 +CATTGTACTTCGTTCAGTTACACGTATTGTAAGGTTAAACAGACGACTACAAACAAGGAATCGACAGCACCTTCCCATCTGGTGTAAGGTAGGGGTTGTATGGGCTGGGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCGCCAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTAGCTATGCCGTTATTATTGCCAAGCTTAAGGTTGATACAGCCAATCTAAGACACCTAAGTATATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTGAACCCAATTTCACTAGGTGCTGTCATTGCGTTTGTAGTCCTGTTTAACCTTAGCAATACATGT ++ +*&)*-10782=:D?2.:995%5620/-/#&%&',3379:85858;;94.335'-#$+$'*0.0(0++-,./:>CEJ@?D0)*'"%#%)&'%%&(=364587+,)&'#$&')($'()(),/-766*$$+$$()$%-34:)FIK<CEH=..BBD>@;5BKJC=>@=-->&25:81459;6>C:-88=>?@?>:;8578112--D<=;;=<@CEFE>B=ACA226;29=;66/.*)2'22.,%%&8;>IDBFA=B662303*B35A7=>AD@;&&:02)<>16:CEG>@96().,*')&'&&$%'#$*,,/+,0)))/0,***01+57976;B??>?;94+9/@A@DBDE=;5>;63%%-021>@F>FD=>BD;,@>?9?B<HA0(+)'210);58?C;9=4;<>8DA;@GH??BDG,999?AC?00CAHCBBD@GE>@B=?:1,%&&&:?9>I<AAACC>>4(//22&'('007;B/;=5**3546<842*/*,2//--,#$&$$# +@SRR11410539.1929900 1929900/1 +CATTGTACTTCGTTCCGGTGCGTATTGCTAAGGTTAAACGGGCGACTACAAACGGAATCGACAGCACCTTGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGACATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAGTGGGTAGTCTTGTAGTTTAGTTGTTCGTTCTATGAAGACTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCGGCAATGCACCCCCGCATTACCTGGTGGACCTCAGATTCAACTGGCGTAACCGGGAGTGGAGAACGCAGTGGGGCGCGATCAAAACAACACGTCGGCCCCAAGGTTTACCCAATATACGTCGGTTCACCGCTCTCACTCAACAGCAAGGAAGACCTAGGTGCTGTCGATTCCGTTTGGTCGTCTGTTTAACCTTAGCAATATA ++ +%#$%*0/679?CE=(,),3'356;@C,*)((0EGC7:7>+144&%$/*-02*;9;33:=>B;;@@D;=::=48=48:<O;;9:<<9:<B?;9?;@243=;83347;82,%#$%'++%%-)5@@H;=C>@@=:=<::6558)+)-(($/.66:?@=;C=B89+6364<579:IF=7(((--)+,55<@?8?04-42337B@AID4+.&&10+-./;<@:AA;6<<9?=E@J:51,52-'%':::8600=:>6:<GN=E<6-=+>=DBE@=?AE886BHJ5,5&)2),;;=A=;986$33680)++9<<GG=987;7625,0$%$$)-.22/006'++#'547:2((&)4/;6236+///))-424427228$@=72++@=?=11,<:8/%&''-)%%$$*)(&+->;A558;AB5,8'%,6%%%$(,22*733:>@?9=62@DBB<7>?<>:-,1110$%6857>?B46@BC8=8.&/.+*&%%& +@SRR11410539.618447 618447/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTGTATGAAAATGCCTTTTTTGCTTTTGCTATGGGTATTGTGCTATGTCTGCTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACCTTGTGTTATGTATGCATCAGCTGTAGTGTTACCGCAAATCATATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTTA ++ +&55.1-=AB9;I2:<;FB0=@CDDE=><2**@LIFK@A66A>>A@9D?DE=?02;>::,,,0+-,/,'89@CHCCGFC:<5H>:;42>8445648;9@<8NI='&EFLC@?GEF87755<?11B>BA>79<HBD=>EEE?EE=E?IGHC@@<++<BH988,,23321%5.0DB:860,,051//3,A;:744==A8646:E1=9;<;8BA=?A:56/14248./*+<>:B>@@?:8;A>BAI>>9<6(+37:&?@<>4>B0/.<;?7*.,-.6:EBOE;=D95$))'9<>@;587A:?;=7>>'/<@B?H?/?FD@?3DFB?==45D?13:;?B7<BCFCC@BB;D>AI3*?08;GFE?;;D?=:3)(1'##'.-;0:?CACB><)9<0?C8?@72&+7650%""%++.+(:(.0>A>'9$9;;EIG?B:.08:E?=33B=%.CCB<;8896+)6638>H84=;<7,)+4?<>HD=@;GDH9>=?8=9=@==BE/9:@DC;4<?>>?D>>=,,&&&$ +@SRR11410539.513337 513337/1 +CAGTATGCTTCGTTCAGTTACGTATTGCTAAGTTAAACAGACGACTACAAGCAGATCGACTAACACCTCCATGGCGGAGTTGGTACTATTACCGTTGAAGAGCTTAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTTCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACGGGAATACGGTTTTGTATATAATTAAGTTAATTTTCCTTTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATTAATGACCGGCTGCTTCGGTGGTGGCTAACCTGGACCTGTTATGCACGCGTTAACGTGGATCAGCAATCAGAATTAACAACTCTCGGCGATGCGCACTCATGGCAACAACTCGACCAGATGCTGCATCGTTCGTTTAGCAGTAAGTCTGAACAACCACCAGCATTTTTAGTAACGCGCAGCCC ++ +-(----'$++-.1,0(:93+;6>:@=420(((0'''%%#&$)&$((%&#%&(#$)*)%##$%%-'))0$-%-',1+.%*44%&((4524738<:GDC>D8;:@@>34/(3554>49DCE>@@;?AF@@;320;9:60/5257-1-*78&*&(277804&364))*+)$$$'&'&,6+)+(.00.8--5&+3.,*$&(+'.:>7<BCAFEILJ367CGGGIGNI;=DB>:B;:C>?=B;=>.%4;9712631/0048DA9)*$'(,37<2?7=EBIB@;<3EJADABB>A.&9,47,2>/1./0:=EC>:?*+>??94+<<;:<@@417-9=>=.))1$%*+%%1'*-.%$$%$&$%#$,)*%***,/&$'%#%*''&%(((%'+'&$&$$%%$&(($%#$'*)'*)$))%'$%&%%%*,&)#%%$#')$%(%')/')&(%&%&$$#&)&%$()'%$$#%#$).,,%(--++%$#"#%%''*.4$&$$$'(%'&%%'%$'&)%%$'%##$#$$'$$##$% +@SRR11410539.286573 286573/1 +GTTGTACTTTGGTTCAGTTACGTATTGCTAGTTAAACAGACGACTACGAGCTGGAATCGACAGCACACCAGTTACCAGAGCAGCGTGCCGCGGGGTCAGCAGCATGCTGGTAGTTGTAAAGCTAGTCTAGAGCTATGTGAGTTTACATCCTGATTTATGTACAACACTAAAACCGCCTGAGTGATATCCAGTTGAAGCTACGATGGAACTGCATCAGCAAATATTTTTCTCACTAGTGGTCCAAAACTTGTGAGTGAGACACTGTGAAGATAAAACATTAAGTTGCACAATGCAGAATGCATCTATCATCCAAACAGTTAACACAATTTGGGTGGTATGTCTGATCCCAATCATTTCAAATAACGGTCAAGGGTTTTAACCTCTCTTCCGTGAAGTCATATTTTAACAAATCCCACTTAATGGCAGGCTTTGTTAAGTCAGTATCAAAGAGTGCTGTCGATTCCGTTTGTGATCATTCTGTTTAACGCCAGCAATGCATGT ++ +*+,&&$&'(&#'2.0)342),*(%%('*($%%&$%$*(*'$+('&$&&((%%13;A<:7*%$#$#$%&&%$)3/&0(+((*'/1(-($%#&%(*43-*',&()($%&%$'&%&(*#)),+$#%%'5>=@=9D?4+))-++8DFCDA4&&))%#*-*/44443..-&,+.01&+0###$$$()&#&+&&,&)&-%$#''*%%%26/0,,010:/%.<&<@AC<=A:96B;?==?1:)>8<33;?=+*#&'&-&'(()%%767150-%%($99;<@89-?5,,(7B3222110+,-+$3%%6655)%23+$$><>=838?<5.(399:7=3=@BBA?>@<632(*(,,0/()%%*()*$')(,'(%%)0*$%('5,1;5558:=9DCD?9;=8>62/*+*/101109<FCDC:;?A3()-*,&'))+5=;DFI@EE;=31-%''%+346%1(.61::)7<DGHA&23;;4$+''+.%&).&%*('+,+&%'(-/35-,.&%%# +@SRR11410539.1324112 1324112/1 +CGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAACGACTACAAACAGGCGGAATCGGCGGCACCTACTTTTGAAGAAGCTGGCGCACCTTTGTTAAATAGAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATATAGCTCTTTATAATAAGTACAAGTATTTTAATTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTGTTGTCATCTCGCAAAGGCTCTCTCAATGACTTCAGTAACTCAGTTCTGATGTTCTTTACCCAGCACACAAACCTCTATCACCTCAGCTGTTTTTGCAGAGTGGTTTTAAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAAAGCTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGGTGGTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACT ++ +%$'',43:;56=E./014>1@@AGHH@CBEG&@EFACA9+*0094=?:878.*)')%&/,5:9+,-)/68==>9<ABE51+7),,,.-((&)%$3539?:35),+(.$'%14687><6B6FH08DI?GEEHBJ@==,:<@=6:C>?@E?FEA=BBABIDC>?>66@.%87?AB7;=>CCEGCCEEB<,40-==CCG?%'%*&,&$,?EB>@CEC<0011.38;--3/2&'&%%%&%669<A?AB>ADD67;<,03=;3*%.<771=>BL<>:;:4*$.1&&3*5?BBDDCD=HA4,)0'%#%'-*)*0/>??G>:393258048@ABAAPNI@4B23CF:=IIM@))24B9>C?8:<>EC>?BB?ED9;@@B:<9></+-?BA:97*B@9>==@8EH93669=BF@?4%'%-2446=778@BF9?::CCI49CF?11=<:@CAEEHIJ@>?>--A2221A28A>9>=BGC-4;@AF11510;6@C73=;;0+('% +@SRR11410539.395798 395798/1 +CATTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACGAACTGACTACAAACAAGAATCGACAGCACCTAGCACATCACTACGCAACTTTAGATACATTTCTTTATTTTAACAAAAGGTGCACAGCGCAGCTATTTCAAAAGTACTAAAGGAAACACAATTAAAGACTACACGTCTCTTTAGGTATTACTAAAGAACCAATAGAAATGCTTTGTGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAAGGTACTAAAGTGTGAACATAAACTATCCACTGAATATGTGCTAAAAAGAAACATCATTAGTAAGATAAAATGTCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATGAGTAAACGGTGTTAAACAGAGAGTGAATGACATAAGGAATAGTAAAGTATTAAAGGCAACTACATGAGCTACCATTCACCAAGGTGCTCAGCCGATTCCGTTTGTAGTCGTCTGTTTTAACAACAACA ++ +%&03596?EF@?G*9$)*272/6658<<>()1/+/?B75''+%&9;@?<<?A,2'(-6@<>?E=9:A@DC<72245>?CB?EG:7;@/%78-:;BDAEBHJKBIEE>D@<;/07=;.(&2A7B>62:<8+:%$+&033/GIF76A::;AB8).5322+-(%(.>>,4F;9=AF=<>@D:OI6.8?,A&1A=@IQ7,>E>>=:16-45=00223;'<+,17;6+8?BHC==@B=BC4812-39FHB11DC>D960%<F@@BCE%-<213....-*,'&*)))-665@AECE:;DBD<GO=2/$*-)<=AEACA?:8*+)>844-6:::=963@AA>??@ADID?:BAAAH;5719)(;:98:8763D;718>=<**%*>=:==?(2,+'%%-377>AGD;C>GH7CAJ7;7@BC:=EI:<FH70A=B@A@@<#$%#$"$#&'./0:%%;88*4?'&*%%#'.547934(;=E53793?:;=32>=@5-,'#&%))(, +@SRR11410539.37919 37919/1 +CGGTAGCCGCTGATTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACCCGGAATCGACCTTTCCTAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGTGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAACAGTACAATTCTGTAGTGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTAGCCTTGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCATGTTGACACTGACAACAAACCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGGTTAAAACTCTTTGACCGTTATTAGGTGCTGTCGATTCCGTTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAT ++ +($.'*#%%$$&$#(*&#)21%'(7138=>F668ENG?A41&&.%-1;:33458&=:/3:?=<56&.&&&+69A:EB=>8=CC@C@EHLJ@EHCGFNI?GB<<GEC??:7-+*$&,---134B:8>>BF@:C<97966655-::;>7>?:;6><5;FIBEEDCB;4-()9,78<?;9CFLJ=?AG9;;)<C@GC?@AE?44?BAD>>>-0:9784=99=>?CCEHIC59@30+*#&$$$,AABI*B:>=@@TLJA9@=@IKACA?BAC>=9:8C4=.0+CJE78<5JH>968>@@>AGBJE==>A66<.:<9:87A<HFAA=>54EELOECB0@'::///,/-.?8@<A5A:8;22?BB?@;;8;'$$%)'+*$)%4?IBFE@;8A<@B>GJJ@FD688>?<887231../:?4</2ADHFBD?G@G=EB@?<:;<>2-,/491>796,<?BDID?>=;;KIAC?>;?<932=BC@87+427>;;@C@?644#%$ +@SRR11410539.2339655 2339655/1 +CAGTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCTAGCACACTCCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAAGGTGTTCTTACTGAGTCTAACAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATATTCTTTTGGTGGTGTCGGTGTTATAACACCAGAGGAACAAATACTTCTAACCGGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTAGCAGCGTGTTTATTCTACGGGTTCTAATGTTTTTCAAACACATTGCAGGCTGTTTAATAGGGGCTGAGGTGCTGTCGATTCCGTTTGTGAGTCTGTCCTGTTTAAACGCTACAACGCCCGTACATCAGC ++ ++$$%(').46:<H<<7;=:?;<@F@E85:--;?GF@C=67:7<??<@87DE>9/3'/03($&'(),%();4BG=>:?@@?@:@@@>:;7HPO7,0/97C@D?A@BD?AHDILHG@>@?A@A@A;?+0+/@=9:**.@EEC@BEFC64*#)89:755,3;6.9:3.)1.*(07E:DED5=B:99AC=?=::C?=6:FFC@@5CIBDCB;+,?@HJBBJJIB+?<90/82:210%**2:DA>227.///;76677<1<9=<:770.7,,1/4/$%%$&02+/11157?%%-,*5%-2368;;//*-./3,%5757>>@F?@9=-=+;;09$,@HDCGHDEB@ECE529.;/2:,CEAC>@72,)5&/2?:;>296CC987&&)3088C@CC;@7;;<<%$=6:/,#%(,-:C@EEDEC>>8))&/BGA@?;?ACHCGD8CIIB;78'%(%+)+,/36=88>A>@:9D<:.?4=BEGCE91/*(-0%(&236')(&(/1)*((:;=CB>78/3('%#($%$%&'$%&&'%&&%$$ +@SRR11410539.2279760 2279760/1 +CAAGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACTGGAATCGACAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCACCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTACTTACATAGATCATCCAAATCCTAAAGGATTTTTGGCAAAAGTAGTATGTTACAAATACCACAACTTGTGCTAATGACCCTGTGGGTTTTGCCAAAACACAGTCTGTACCGTCTGCCAGGGTATGTGGAAAGGTTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTATAACAATACATAA ++ +1%%('*/0245D23,/03-//B8@B?@;.-6?MIFJB8>>??0/,73@8<6&%+-,355?91-@EC=?FI@=@6=7<>;<<<@=GA@@4;=8=DACDDB99:0/,,3@:;1((,HC8;B@?:@BFDF@79::<@93.;:9?@GF44==9<9@DBBFDE=DIB>994*550$0638*9?=,C<04).)+-.<E@87++=4,8B@<6769>?@DF66==95AC3DAA==+.95B=C@B>00837:=>=BBFC</1<9;HC>3=7625(/55344-78=?6/>&)'8A33<3CE<B@=?BFE@?@>DCFG629299:>D9889C/%%%%-.:5C5:;>?..B;=>$$);?A(550=@>6-,++-.(&%'(%&0$$+27:AB5-,7(0<67559<DFFC;<BEC=9656A>?DD<9/$$&67424@A;;=@??A>>@<:?B408/644)/$$967--&0AIB9AA??@?=<A>>@=<=7:;DCCA?7<>=A;>D@601%%()**21,'&-%'%% +@SRR11410539.745498 745498/1 +CGGTATTGCTTCGATTTCAGTTGCATATTGCTAAAGTTGAAGCAGACGACTACAAACAGAATCGACGGCACGCAGCATGTTGTGCCAACCACCGCGAATTTACTTGTTCCCAGTACTACAGTAGCTCCTCTAGTGGCGGCTATTGATTTCAATAATTTTGATGAAACTGTCTATTGGTCATAGTACTACAAGATGAGACACCAGCTACGGTGCGGTCTATTCTTTGCACTAATGGCATACTTAAGATTCATTTGAGTTATAGTAAGGATGACATTACGTTTTGTATGTCACGAAAAGTGCGCTTGATCCTCAACTCATTGAATCATAATAAAGTCTAGCCTTACCCCATTTATTAAATGGAAAACCAGCTGATTTGTCTAGGTTGTTGACGATGACTTGGTTAGCATTAATACAGCCACCATCGTAACAATCAAAGTACTATCAACAGGTGCTGTCGATTCGTTGTAAGTCGTCTGTTTAACCTTAGCCAATATTTATA ++ +-$$&$#%%))+(%$)-0+.124,42557=>><76*721*/6,;697+3&860/78+3234==8<9=$,5/%$*%)2-,+A>*@<A=++50&+/('%&'./*%*.045814+3(-&*%*3,.*4%&&',+?5347,,,&*1:;>CCACICFMMI@B;C=<DF?C:9CAFD@GCHJJ7<<>;-,(1%%')(%.,;6'*35;=<934-<;;//<23%%$'+5=<1121%$#&(&&2'&&/,.''(+,1()'26<=D==@FB;4+-0((06)*,,($(-2*<B@DA70,%%%$#'/499/3:4-%#%'''1183(#$%-0,+/>>@;A>D88856,+790(/=?AB:H?=@:GHD:9979-$*-2>GFEEIE63.-*-F?;?=8:9AC@?CFCB;;CMGCUF:>?@<;GFFFEFGF::7<<BAD?;A=?AAH@>9><=925+)387A66=;;74BBE@<C>BI*64;<(&)(1=A?;@?A<>>00./0//(&-11+)#$%$## +@SRR11410539.2282109 2282109/1 +CGGTGTACTTTGTTCCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGAAACGGAATCGACAGCACCTGAAATCTGGCAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTTGCGTACCAGCTTGTGAGCGTACTGTGGCAGCTAAACTACCAAGTACCATACCTCTATTTAGGTTGTTTAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTCTGTAACAAACCTACAAGGTGGTTCCAGTTCTGTATAGATAGTACCAGTTCCATCACTCTTAGGGAGTCTAGCCCATTTCAAATCCTGTAAATCGGATAACAGTGAAGTACAAGCCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCATTATTATGGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGAT ++ +-%&*$*'12379><-/14ABCBBDMACAC9==6INIFICC=>A:A;9=93%'$31.2%)-2<>@9-(;=<=;*$'&2()&),6@BC7:DC<:<438DA=DC<?:?FC;;=<?99221:5,891?48>:=(+%/-00'&&&)/2+,+9:?879)3(-.;,9/FGA@;047;<8A><<>;A>;@ACBEB:85<A;8AC@AA558ABFBG?>?75CB@CFJCH>?@@@;>?:D4DG<?@A@D@?;>@B@9913::=>37345/0)7==?B=9=55=<AA?=A@C?>61633=>A=>;9:8?CEDE=529*;:5&/8/;=EEI9CE9?;;6++-@???DC;C=A@?A@/(-+-2//01489$('-.)/2;=CDFE;BD:=>BAA<9;A::F>@7856;-,-('))++.**+..-,23CDI<A?879887666//+&,0//.(' +@SRR11410539.2327446 2327446/1 +CAGGTGTGCTGGATTTCGGTTACGTATTGCTAAGGTTAAACGGGCGACTACAAACGGAATCGACAGCACCTTTTGTGCTTTTTAGCCTCTCACTATTCCTTTGTTTTAATTATGCTTATTATCTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAAATTTCTTGTTTTCCTTGCAGGAATCATCACAACTGTAGCTGCATTTCCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTGAAAATCAGCACCTTTATTGAATTGTGCGTGTGGATGAGGCTTTGGTTCTAAATCACCCATTCAGTGTTTTCAGGTGTCGATTCCGTTTGTGATCGTCCTGTTTAACATAGCAATACCT ++ +-$'')#$#$($($5?3;$+%)$-'2..0=;;,,2GKD@B=;*++7+++-(*)*%%2429;=@EDCCBC@?BAB@24.14453.&$$$.%%%&%7756.4/3>:?CLCDIKKL>A=DC9=?A<?IFG>AHC<GD<:;:<ADBHDFBC?=<@<>ADBA?=+%/5<<@+)-BC8EF4=227-2/,626<;?L<N18:8B=-0<=/*)796;;<><<?978>@><9=>?668DF;(-/38./*EK8<=9?DF=2311:>DCE8><B@;<A40<55@;;998B?<<EB>=9<61/17C=,-->?>>=>881>>??+?)>@EB<@ACC??D35'58;;9?:=6+*2:0.0*6845933,#$%&%)+663:3*8%%21;*''&&"#%'+2B??5CEFBAD>;B9:90,,'%$&%%#%(((&1<BBIB??9<;5&()&#$&&&*418;3)(%68>17<943*)& +@SRR11410539.2307189 2307189/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGGTGAAGCTACAAGCAGATCAACTAACACCTGTGAATATCATCCATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAACACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTTGTAACACAAAGGAATTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAGCTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCCTTTGCAACCTGAATTAGACTCATTCAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTGAGTGACATCTCTGGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACCCAATACGTAACT ++ +%.0+4.23712?42.9><:=;BGEH2-A5631//9:40*/))*')(*)&'#$&((%-(($%%%##$))))%$(%%-3296%%'(&%%,./:<<>0A@=8=6?DD?>=<21,./(/009:HA=C;)9>?BA<<@C@<==77:552*+2'()03@'50'(/(+33.)4($+31>CHEC>CH9470@@=><>4><'.;9=<?@C7:?<:>EA?<FAB:;BB?656*;>@HCABD9?>9@;<69?A@;**7:9>5DC*.9;9=<92**('%()%+04;:?;:=69:>474.+3448.359<6<=6:432+1%%++15;?<9:><=<,++556AD=9@./90-+7)&<;<;6?@823=//772701>@DA@==;;;C?B@CA<.*>&,710AF=B9DDEGE;?863.#$%&&)9%'3=;;:6666@9CF:8CBGF2%$2:;*8B?DAFC;;2928?19873?EEHA;==DD?3;;?<@=9:A=49ABB@>HI53))*++114..'*%# +@SRR11410539.2200529 2200529/1 +CGTTATACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGGAATTACTTGTGTATGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACATCTTCTTTGCTCAGGATTAAGTATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCGGTTTGTCGATTCCGTTTGTAAGTCGTCTGTTTAACCTTAGCAACGTAAC ++ +#%$$%,,238<>O860@9=A68464667*=*EDBFI;=9@:=>=AEHAFF5:$'#):==<(?&;@AA>6=EBD==6;<>@79=@3)3;FCHHNKEE=7+*,-056DB;=8:%%*:@A?FCAED;=<:;FBEF=*)((8;A><F?=FEM:A(*6D467?>;@FH=<@;;7<><==?-223<<55357CFD;;&,$7:8244021310,-%9;=>ABP<?06E>:17:BBBB@?>)-;'(43-8AD9IH7%&;:8A'.54-@-7-9CEBBA=<77//.$%$$8<CGIBCG61<A+*,$%14?;;<<EDA=79/./>A?@B?42:>=9@<9C=@CGFDE88>7FC??ADE76/6431=:69''4.569AC89<@=CA=@AH==6-B;?:DD?;B??=618??@C::@$<@87;=IEFB>?<B@AD<BEEA@=5+&$9*++=A<5=1*/%(#'6;=A:8GGEB8==;0.&'&6:9<C@F;<;++',&'.&+'(*('))& +@SRR11410539.1165351 1165351/1 +CATTGTACTTCGTTCCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAAGGATCAGTGCCAAGCTCGTCGCCTAAGTCAAATGATCGGCGCCGTAACTATGGCCACCAGCTCCTTTATTACCGTTCTTACGAAGAAGAACCTTGCGGTAAGCCACTGGTATTTCGCCCACATGAGGGACAAGGACACCAAGTGTCTCACCACTACGACCGTACTGAATGCCTTCGAGTTCTGCTACCAGCTCAACCATAGCACATGACCATGAGGTTGCAGTTCGAGCATCCGAGCGTTTGATGAACACATAGGGCTGTTCAAGTTGAGGCAAAACGCCTTTTTCAACTTCTGTAAGCCACAAAGTGCCATCACTCAGATGTTGACGTGCCTCTGATAAGACCTCCTCCACGGAGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAAACAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +'&&(9<:;<?99GA%-*<<>=:<7?=>>?;++;BIEBD161320756/+644)</448<?CI@E=GHBA(<12/<@9>9;FD>?;;<C7>;:@CC>8<<7;A<><30,$#%+:84=@E??>=@:.---0834,((+..>@JIEDDDCCCEKFB=98:600'89=<DE8E7::79%879<@03=FF?MGFDBA3;''*&:<<B8AB7CD@4-/014GB<?B?>ED@=;887622/004388?@A;<9,798>DDFFC=78?>ID?-=/0>@8(=%0*778AB>A79+(.;**&)*5=;:.-815,,7++%87<BB=<:<6?@?<A64;<<B>ADC56558/928<BCCF=:;>?:;>=4911**//2'&,-.?=;<<=A:B:99,()#$,'*-25==AD<<@CB591B/C@<AB?>;;G:=>9;.;,0%:9<9);FGG?FB993<<;-->@3?;9C33BADBCHED?A>/(/,3>@DEA@59>B>?>;=9BBE33@><@;:?7@78444987;?8;BA<<72884'* +@SRR11410539.1427267 1427267/1 +CAGTATTGCTTGGATAGTTACGTATTGCTAAGGTTAAACAGACAGCTACAAACGAATCGACAGCCACCTCATGGCTGCATCACGGTCAAATTCAGGTGTAGCCATTAAAGACTTTACTTTAACTTTTTTAGAACAACTTCAGAATGCTATTAGCAACAGCCTGCTTTCTCGCTTCTGAGCAGTAACAAAAACTGCATATGATGGAAGGAACTAAACTCTGAGGCTAGCTGTAGGTTGCCCTGTTGTCCAACATTCTTCACATAAGCTTGTTTATGTCCTAGCACCCTGCATGGAAAGCAAGCAGAAAGTAATTGAAACCATTTTTTCAAAGGCTGGTATCTTTAGCGAAAGAGAATGTCATTAACTGGACACATTGAGCCACAATTTAGATGATGATTCTATGAGTTGTTGTTGCAAAACTGAAATCAGACTACTGATGTGTGCCAAGGTGCTGTCATTCCGTTTGATCGTCTGTTATGTTTTGTA ++ +)$(&%$($'''(+&$#%%+(-$%$$)),-%&,==4,-+&%'(&#$#&28=>:,%$14..''%)),(34;<*-)*$%#,5:>4CA>6C8;=B+.(1)0'#($$$-1012,*,$$+&$#$&$))/7:G@8,6&*A?99=>404,-0,%$%*,.2(1(''$&))&$$$%*-&$$$%'%$&%*-('-''$1:<3%/969687>?>:,-&(13++,--/.:=<;<74,%)%$#%%(--/:<;AAFB><=0('.$$*),/(++$%%%&)),+,.0?@93*''#$''245772'4:6./369/'%')#*,),/954&&&(.+..38;:<PEA=+66&()%)%&+(59?>1(()().%.(.)14788&&'&'25;=:;54+++*&...'(9=9BA=9?A>?>87A@<8,&**8;>>;<&>B;?>?;593-,*%$#$'$#++16<;B1$9A<$;56*/-+*,$&&&&)+.354(&&(*)&($%&(%$#$%%%#$# +@SRR11410539.1664447 1664447/1 +CATTGTACTTCGTTCAGTTACGTGTGTGCTAAGGTTAAACAGACGACTAAAACGGAATCGACAGCACCTCCAGCAACTGTTTGTGGACCTAAAGAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTTAACAGGCACAGGTGCTTACTGAGTCTAACAAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGATACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCCTAACCGGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAGGTGCTGTCGATTCCGGATAGTCATCTGTTCTTTTTAACTAAGCAATACGTAAC ++ +'%&&*0+-.023DA@:@?7*0,*&$%.9@=9:1E88;='2040<:6449:7%935277633)+$%**-.7>E<9+,;=B?<<::AB@;=9-.%$)'':<CBA<ACECJ=AEFCE2)&-574((9+-1345;CF44AJ:?BD??AFFE9&&155<76,5:>6;9=>=957230<4607:::510/>;?><9;<?=A69::7<>;=A.(&-'&'(&,./)',-'#%'3382DAA?<=4454./12348++++;<<887:69;EDAJFFFA99=C@C=>>=B@?>F=DB69==@9,'82<=;.9;>..@C@6@2>:;789966311$%;:=9?$(?AHAEDA?>>EA@1-7/<=;AB?@0/.=+<A8?4779:;>E@@@>1'/;=>AB?C?EB:3?23=>>B@>%*/;9:;34:;E=48@;::@<D=:DFG/0267=>;<D?=?<?A;B9?D@AACFCCBB=:891809AB=>?568?=<>;7;><E>55'*%(%'14.664.40&&'''&**''%'$,320%$%&((( +@SRR11410539.819470 819470/1 +GTGACCAACTACGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTGCAAACAGGATCGACAGCACCTTACGACAGATGTCTTATTGCTGTCGGTACTACTAAACTGCTTGCACTGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAAATTCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTGGGTTTTGTTACAGACACCTAAAGGTCCTAAAGTGAAATTATTTATACTTTATTAAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAACTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGTAGCA ++ +%'%##$###%#*1;<.(-2-$76//&&%/5'(1BFEDG>:8;9<87+-&-13.)%&%',.00-**))))(((29<>:CAA89;F5**-2/1+#&'*)&:22%%;?A?D;8@@--=>=3/>@DA8???.$.--5<<9;>44477<<387&.526272/9=CDA9:7455*'*/0'/)&))/((2:3&&&66+,/,'2415*+*/3'*(9:-.8>@&)4=;:>+.986>;><797-+9/00,+-,.3<A;=7>8;*354765&,@FFM</9-$(++87*9&:>?2&)'',8>?4.))%)''.1132+,+,146=@?BB.&)94=9@A5?45D=BILC6920/2><A367><>?23/44DF>C:<>?7?31+07<<2->,&568)38(&67<=>=,-/A+.-?GEAABB7@@@>6>2/654.:(+?<:>?CED;H?9:;;;46826;5;H@DE::;@8:G>98:8=BDGC?B;FED.*..7>8=9D;>?5$%,,--&+,*)$&$&$&# +@SRR11410539.56894 56894/1 +CATTTATTACTTCGTTGATTGCATGTAAGTTAAACAGACGACTACAACAGATCGACAGCACCTACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTATGATGATTTTGTTGAAATAATAAATCCAAGATTTTATCTGTAGTTTCTAAGGTTGTCAAAGTATTCATGACCTCACGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTACCAAAATTACAATCTAGTCAAACGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTGAAATTGACCTTCAAAATTATGGTGATAGTGCAGCATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTATTACCTATAATATGAGTTATACATTTGGTGCTGGTTCTGATAAAGGAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATGTAATACCATCAAC ++ +/1782..1)332'%)+**27-1(&$(%&420.2-44469?@>='++)''&67;<A;F9A91/A<;>>@KJA@8A>792,)2,441?BEFGCGFAHE?:;<;59</879?>>?:32)68>9>FDADA674.-89:696877=::>-$&<35>B5:<?=BC0*8$%)%)',,%%+&$'$$%%'$%,.;>BB@@AC?=?;CCH>?@DFEL92ED?@@<B?>2>0=;(;5?A1&%&-,/+,1-440(:($%,,)*'*&95;?881>*,+C3A<(#(.3-3*55:88><3*33530))6??*+*2,-1.+*/'',,$)*)57698KO>85:32$&/:<?C?;3++&+*1/)9:9./()%6+-,.,*-:766)*21**68886.+*>6>>A@D;>;3@=>GHNH>BEGDHEHGDFFH11.0&&'%$&&1*2?=;>A?@?&+(0340=<=<5*+;,+79;DEDBFC>>@$524.0,%6%37-(2'%(-)28?A>/5()8;64@:4><71/0'%&%0021$($'()(% +@SRR11410539.1549846 1549846/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTATTTAAACGGAATCGACAGCACCTATACAAGCACCAAGGTCACGGGGTGTCCATGTGTTTTCAACTTTGTTATAGGTGAGCATATAGTTATTACAACTATCGCCAGTAACTTCTATGTCAGATTGATGTGACAATTTAAGACATTCAACAACATCTTTAGTTTCTACATCTGAATCCAACAAACCCTTGCCGAGCTGCTGAAATAAAAGTAGATAAGACATTGTCTAAGGACACATTCTTTGCAAGTTCGCTTCTGCAGTTGCAACTAGTGTTTTGAGTTTTTCCATTGGTACGTTAAAGAAGTTGATGAAAACGTATTAACGTAAGCATCAAGCATTTTAACTGCAACTTCCGCACTATCACCAACATCAGACACTAATGCCTGATCTAGTAACAGTATAGGTTGACACATAAGCTGATAGCGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTGTAATACCTTCAAC ++ +-+./2>9<=>967.=3>?B9@A@?<>?B?==,CKH@B-60205<:83*&&(359:/2(07=AA867:>BAIGEIB??8BGKE=:-943-=)/@9==''4%,-(0;=G>?>?;ADD@?@A;)::912*5:AAABDC@663+:4549A:=FFEBDB40-;=CBH:@=@?=AEEDC:9JGI=EF@FE<?=49<>=BIH?>>DGAEPF?AAGFB:=CCB>CAA:A%%=**9FG?HBCGG896=BLBHFEG@DL@=EGBA<CD@B=EGCHD>?C5267;3?CI:C?A=>AJGA8=@A@;+&+33578:;5>4734++;?DAFD?=>:=<FKIRGG=AACB@DGJ@AFAEF3,,*?@DFDFEF@OHH>DDED79B;;ABE@;8<88+6;99;2&)??588/-GJBE;>@ADI@D78;:;><67$$A;B>G?C;<;7734=>A:=@;<0*/7>=00:?AGI@A>@:89+%$(#+)%&$(9724@>ABDFB:9367E8BD?8;3,&*?AB>**&&$'+,6642&,%%#%&$ +@SRR11410539.2008465 2008465/1 +CGGTAATACTTCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAACGGAATCGACAACACCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGCACGTCAACATCTTAAAGATGGCACTTGGCTTAGTAAAAGTTGAAAAAGGCGTTTGCCTCAGCGAGACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGACTCCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCGCGGCTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAAATAAGGAAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTGCTGGTGCTGTCGATTCCGTTTGTAGTCGTCCTGTTTAACCTTAACTTAATACGTA ++ +/&()((*8674%(A@<;478<3>=<>',>??<=7EA@<>'1*+01=50,671//2072?@E@'(;<A@@>DC?@C3?@;AGNLHEFAE;7H@AB;496-(;--%%%&.-+%2009:=DCAB0,26:6:??9525,,7<3B?=B22A?:?>9DE@>=C162(&&&(-,,,-34**&$2$);5521$*??BG@1,002.7%'&%%)*6%;668?928AJJFA<A@B958B4<,/0,-/16:59;<?@=95;56>9A?C=>@B<CB@C87:7<AA2545,*&'977$88*351:3225.956?<:2>$&&176-2<3&=946669:6/*3))+.7>9?=<.@<869;F?320:66>=8;@AEDGB;<=5<43)7>@?A<?B:><;&',.49$*212*130*9CCDCB=AA>>@>?562184B9<?876%%1,3DE30;B677680//@?>99+*)4/15524;@686;?))1('))&(/%(/*(9<>@A=<?IDA;9?=<@>**.D;98A>>=B?>%%%%%?B@A<:*. +@SRR11410539.105820 105820/1 +CAAGTGCACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAGCAGTCGGCAGCACCTAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGGTGATAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACATAAGATTGTGAGGTGTACTTAATGGTGTTGTAGTCGTCTGTTTATATATATGCAATATTT ++ +-&'$$%$%.56:?F6=7>@C?.'A8@A:=+2&?IHHK@92527==<=;:;;(,%$/6$&,')+,,)0:>;<=4655<$;B<B@:?B7?@@81>=>>?9@>:>@IJIDJECBACA?G1-@8=>>@CEFJ@JCB?8%*7BHEBIJCDDBAICEFCFCHF9>HE@;?B?:::<=E7/=>FA:=C@>A??;832+.9BABCM8,,124978:AAB?>6122//851BB::BC?<;8;?;<<>2247:??@>:<82?@@BCCDJD55@;E5?@A,<&6<::9=9=32=/@??@C7HLB<DC==<=>>;8D@>?==>A67:2,764;866/3?A@IAADA47786/+)/-13;9:9:61-853,+(023$3A;A;;<9@CD8EEA?=.:<<;>;=D=HC@FKDC;</*/-03/(=66??>EIEE@?<EGIGBBA9@9;).$$%'%#,3045)(*)&&&$%%&'-$%(&%)49<>9;6883389++#,*%(/2,245(.%'& +@SRR11410539.1167057 1167057/1 +CGGTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTCCAACTTAGGGTCAATTTCTGTACAAACAACACCATCAATTTATAAGTAACTGGTTTTATGGTTGTTGTGCCCGGCTTTGTTTTCTTTGTAGAAAACATCCGTAATAGGACCTTTGTATTCTGAGGACTTTGTAAGTAAAGCTTTTTCGTCTATGCAAACCTACAAAGTTTCTTTAAGGATTATATGTTTATAGTGACCACATGGTAATTACCAGTGTACTCACTAACAAGTAAATGTACCATGCTTAAGTTCAGCCACTTCCAGGCAGGTGGTGCTGACATCATAACAAAAGGTGACTCCTGTTGTACCTAGATATTTTGTAGCTTGTTTACCACACATTACAAGGTATCTGAACACCTTTCTTAAATTGTTCATAAGAAAGTGTGCCCATGTACATAACAGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGTC ++ +*#%%%)$7<;>;JF405<7/4221224)0-./A<;AC;69@B?@:8/*9DB?4588?>>9D>K<EI==EF4%%<23CGCA<=<27?A;?@?AADJABEB=--ABBA0)BAC>BLA>/0--:<:>?@MHNC?B-/01/56-2'%%%#&$%'&$','),6:='''25:K>@B:<>::>>51776&*&(14==>2>-5+<CE>JKJ98*++8453'110../56::/)(#$$%#%$&#%')$,7;?<B@8%&'%%(()8=8:FECB390>;<::-()725:676.%88;6D50,/.2'#)&'--0,5;=A773('''--))*((.64+-$$%'%%'#%&/442119''&('*,.//*:*<:=8@>>+'5<2/+/%53;BB7+*/$653@;7=:C@1,(.56898<;=87(+12$$+18-.28<:69<=<>>8((((*-24,/019;A6558/0/;51;CCA@@?4??C?+=5A;<=9?4/:5A:8B;88;:CB=>7:893.43662664455.+,*/*+%##%&%%))(&%$ +@SRR11410539.635065 635065/1 +GTTATTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAACAGGAATCGACAGCACCTAGCAGCATCTGGCAAAAGCACAGAAAGATAATACAGTTGAATTGCTTAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAGCTAACTACCAAGTACCATACCTCTATTTAGGTTGTTTAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCACAAGGTGGTTCCAGTTCTGTATAGATAGTACCAGTTCCATCACTCTTAGGGGATCTAGCCCATTTCAAATCCTGTAAATCGGATAACAGTGCAAGTACAAACCTCCCTTTGTTGTGTTGTAGTAAGCTAACACGTTATCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTATCTGTTTAACCTGTAATACATCTT ++ +$$'('+)44=@?H6>;?FFA?:CADA8=.==0:FFFI>><;>3;/*(268,&;<,5>AAE=GGHFBB7230*'(626)$)8GHH>IEI9=6AEA)FG>?IG?:BB84,,+2*$$$''8>D@A@B<?FG?C<<=@KGFGBDD4,<;B7;A><?>@9;28/000-99AA@898E@A?2--;9@CECDGD9A?DC<HE?7:78<887:=@AA=6EBFADJBA<?/;;9>?<3>@A49389?35>3:;;>:'1--045)-,77<=(9>79A:#%%%4100303;118/5-2-99><??9:1-;-,5<?80;779:14-9@GFG?BC4A9:9567@@@=A=6>0347''2.7<98*+)2**(*&+&);>43;@:?=9C@ECA7=<B@B9<7--0'+*&'(+0('800D@A)((/(>==@732676?>?>73/-8:<;9;+8?<>FBB<B=<%&;B>=<DD<@@DH@=?=B@5+12(,342-'$%$&&()%##&&%$$ +@SRR11410539.1263560 1263560/1 +GTTGTACTTCGTTCCATTACCCTTTAAGGTTAAACAGACGACTACAAAACGGAGATCGACAGCACCTAAAAACATGGAGGAGGTGTTCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTTACCATTATTATCAGCTGAGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTGGAAATGAAGAAGAGTGAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACAATACATCAACA ++ +$%&()$))*(501&(-/3<><6657))1AFB8<%<;=>;<B<@B?@@35=(*,%/(:576?;=791/9:,*(04=.85..//5))(($'7()%'''-24:9346.%$&%,349BGDCFCBEC>?4;07@9??BCJAGFDTG668CF@FE@BE6FJDGG?@FAGB@@3,?455?8:BB<@G733?::7CD1>@C6+;>AC<=LI@?DFH>DC66:=>D=>856CC<6736865>=E01=1;>7:7*-+()33=<@;>=3/%8=@F=--+=@;:9BGHBCDG>JHLQF<93B?AEG9%%%?EC9,)$%&*)-3>@FBGC876/5;1*'',/38887%&766>EA77<84/8ADB?>=>C22&%'26B:8:>F=IHD@BA><>34=:7::9>:==>;=5/.75?=?CC@=>776=B09;B?A>7FHCGG9%%4>DCA::<<ELKPIAC>BFBCA?&88844;AAH.@>@CGAA=@>DFD;;:BC@&,397=?<>68@;92+*($&%$&)$%%&)% +@SRR11410539.1857886 1857886/1 +GTTATGCACTTTCGTTCAGTTACGTATTACTAAAGGTTAAACAGACGACTACAAAACGGAATCGACAGCACCTGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTAGGCGCACCTGTTGTCTGCTACTGATATAGACGTGCCACATGCTTTTCCACTGCTTCGAACCACTTATGCCTGTTGGCATCATTCTATTAGTTGATTACGTCTATAATCCGTTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCGTGAGTGTGCACATGTAGCTGAATTGTGATGCAATCATGACTAGGTGTCTAGCTATCCTGATGCTTTATTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTGTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTCTTTGGCTATAAGCAATACGTAAC ++ +'&(0-,&&&(+,+0/-%$'4<0*%%%('#)-89''36;=@D@<<>684-/-5332287;)3:<>E94:@89=82,%&103-2&&,589;EIFEE57:0(*%&''67>>><&%56;?E922,;0/*%)2)-0043:8571762+-+%$%,//,(+-,1&2%,/'7466;=AHC36?ADB;=-)($%#'&&13=29BAI2;=.51:=B=?/?-2(+%:.0:867.758??:@AF@EF>@?D3,*776EFDJ;HAC>?@--+*,-?EGI;624129:>BAD=?46003++/-(())5;9'((:<(6=**0$$/&&#$%*%40,,81//.6/52.,-)+).**<0@>>7900+(-,&*5?.)-.A<?;5++)&)('''')1'15*((55;3;<112+8<=>:32.&&0/19;<AFB999=.03((+((20(*)0>CED>>A@C2;667*2:071/5>3-($)&%?=?=3.@==GI;>9B@36655+56<4-'&')*)'#&%.&)&+&(&$*('&%$ +@SRR11410539.920390 920390/1 +GATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAGTACGTTTTGCCGAGGCTTCTTAGAAGCCTCAGCAGCGGAAATTTCTTAGTGACAGTTTGGCCTTGTTGTTGTTGGCCTTTACCAGACATTTTGCTCTCAAGCTGGTTCAATCTGTCAAACAGCAACAAAGCAAAGAGCAACATCACCGCCATTGCCAGCCATTCTAGCAGGAGAAGTTCCCCTACTGCTGCCTGGAGTTGAATTTCTTGAACTGTTGCGACTACGTGATGAGGAACGAGAAGGAAGCGACTGCCGCCTCTGCTCCCTTCTGCGTAGAAGCCTTTTGGCAATGTTGTTCCTTGAGGAAGTTGTAGCACGATTGCAGCATTGTTAGCAGGATTGCGGGTGCCAATGTGATCTTTTGGTGTATTCAAGAGCTCCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATAGCAATACGTAGC ++ +'$&%('56999@@99<EEG>CCCBC;?>33>DHEKOH@99A5B@77<>@DC@?AFG=9<;1D.DD58?8/3D@@@KGPA3.$..2+%/:33<EFIC867.;8924)%$&&&%)*0204724<:;8ABCJ7>8-2:>IH.CG>=>;>;@?C82100+$835;GG@A=?9>9:?:956=/73<>AA:35;:%-%6=%%<>?;26@?+78<A&'6/=D?;:1>>&&..<;8688@I0B(F75<5@B?C;><:-7977%(5426<FGI=?0A=5.<.DDLEDDAFFCE?HIA;488;D@@EEBCGB66550A:1('/++(%'7-<>=>;=@>>A>:A?.9BEEDB@CE8I5=66997666>?BFG79GH9EC?B?@A5AA78;8=4./....:,+-31+-024;<GE<?:4@BBBJ?C46-EBAABCCC<?D?@JDE@17?A94453&'+$'16;<>2@01A:78::6:?A=@@<:89:?9;@<7?==?=@:72+)%*.-44;9327&$%&( +@SRR11410539.2170521 2170521/1 +CACGTGCTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGAGGCAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATGAGTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTCTTGGCACTGATATACTCGCTACTTGCTGAGCTTTATCACTACCAAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCAAGGTGCTAGATTCAGTTTAGCAGTCAATGTATTTGAAACGCCTTAACTCTGTGGC ++ +,$&%'$7:A=;D-+%;;?:E?EDBB'%.%8<007:)8@;CCCAB:B;DC<A:>=C@?AC<;;@BH?/:?ACEDCA?8@?(-33FE@6-0EGDB>/))A=16<>F@;EG?=DB@>><=5*$%')213@C@HC@EGDD82@46COD@@CIJ5.'-&16.+66;60+/'92:;::>7'/&)&&$(=4<@=+10@DD>GJC9>>2104D?CABDL?C=<:>B1.'%*24?;;:7;<578>?56,)&03-2412>CJD=>B899>?A:>E;59:;'8A@=@ADEFCC=DFFHF@AE9>53(($@A?;8DDB@AF@D>DIGREDF9B<<)&57%'8?65:;=>?FC:83541>D=?A?1.))'9;0/77///%$22.3ABC?@9B>AEHEDEA,(?GF?BDE8?20-@C@B56/<,84<>>>3==6'%'+*))/19?@?GD@(AADD@D?@:=85CBABA@?@B>>ADF>?++367&&&$$'1')&.,1-%$%()&.#$%$#$%&&$%%#%$%&$$#$')&$%'#$# +@SRR11410539.2162857 2162857/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGATTAATAGACGACTACAAACGGAATCGACAACTTCTCCATGGCAGATTCCAACATTACTAATACCGTTGAAGAGCTTAAAAAGCTCATGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCAACTGCAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTTTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAAATCAAATTGGATCACCGATTGGAATTTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCGACTTCTTTCAGACTGTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAAAGGTGCTGTCGATTCCGTTTGTAGTCTGTTTAACCTTAGCAATGAC ++ 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+CAATGGTGTGCTTCAGTTCAGTTACGTATTGCTAAGGTAACAGACGACTACAAATGGAATCGACAGCACCTAGTGAAATTGGGCCTCATAGCACATTGGTAAACACCAGATGGTGAACCATTGTAACAAGCTAACACTGAAAAAGTCTGTCCTGGTTGAATGCGAACAAACTTATGCTTAGGTAATCTTAGGATTAGCTGTATCAACCTTAAGCTTAAGTACACAATTTTGCATAGAATGTCCAATAACCCTGAGTTGAACATTACCAGCCTGTACCAGAAATTATGATTAGACTTACGAATGAGTAAATCTTCATAATTAGGGTTAAGCTTATGTCTTCAAGAAGTGGAATCACATGTCTTGGACAGTAAACTACGTCATCAAGCCAAAGACCGTTAAGTGTGGTGTACCACAAGTTACTTGTACCACGCCAGCCCTCAACTTTACCAGATGGGAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATCTTGT ++ +%&&%#%/)7-++,'$#(.4/4:7357:7<A269--1&0&*)&(%./7997842)#$'$*-.133//28=;8-/4?25..8(/256=D9;A>A<AC@?,57?BA@9/647::(.)88757<=@:?;;?97$%';;@BB@?@HD@46:??8++51%'23;:?//-$%(*)/211+)%##$$%)'/$$'(&)*),(--)-33'...9**,+)(++.+,,779:6.B?BCADIH8=955:6=:7((966%9:DG>5*)(-376:@A8961269AAC=888.?&6511782-+)+34<898<:66B9((8:9=A=CIFB8746448-,0$($&%$$$-,,16<.4))%(')/(*)04=974..0/)()-7607412*+-()+,0),:23%)2>?86;024;>572,,-$%>;;;>=69662%,*++++'&(($'''&&'88-,4,-/000,+3/7:=&-@14*2?7433-::3687<7<;8&')5251.<32.,'$&$'$%%%$%#$#$ +@SRR11410539.151547 151547/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGTAGTCCTGGGAGAATAAACACCAATAGTAGATATATGTGCTGGAGCATCTCTTTGTAGTCCCAGATCACAGTATTAACAGCCCAATGTCCACACCCAAATTATTGAGTATTTTCACACTCTGGTACTGGTTTAATGTTGCGCTTAGGCCCAAAGCTCAAATGCTACATTAACAGGTAATGTTTATTTTCAAACAATTCTACATCAACACCATCAACTTTTGTGTAAACAGTGTTATTAATGATAGAAACTGGTGCGCTCACCCTGTTGTGTCAAAATGTATATTTACAGCGTAAATGACTTTCTGTTTCAAATTACTTGTAAAAGTGTTCCAGAGGTTATAAGTATCAAATTGTTTGTAAACCCACAAGCTAAAGCCAGCAGGTGCTGTCGATTCCGTTTAGCCAGTCGTCTGTTTAACCTTAGCAATACGTA ++ +&-.45378:<8G70+7GE@<:><BA9@966%08AADF?@?ABE@D?<?;8:<6,12<96:><=:9842-(#&%+,''-*$&,1(%&&(,./403::?<EDGCA@?-@<?C<<D>>?;;;<?@?A?<31%%5458679293310.4()%%'*&%..45/213A1(67AB2,((-&'..-7BDHHM>E3@/-;AC<BB??G>?JKDBG8:FE1:-**--+)+++45((E/=78:8:>ECBCFA2865<;87:>?>/@:D?K0@=?7@??B;<A76/,:<<?D??*$?..,,,,.'D;@EF4>:=HGIKDG?-0**+(&#.*'((()/%$$%-(-;<8?5<>%%#(('(%$$#$&&%$$$##$#$#)#$#&&%"$%'&&$##&%$&$$&%&.34368B>=EE:;+1A1,,DE74ECFDJ?9@9=GIHAEELC:<A2AD?>D;=DCDEUI>JBF77>60A?=9@<>ADED<?8C9+$$$$57:>57938661()%%%'123>;11=6-- +@SRR11410539.590637 590637/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAAACGGAATCGACAGCACCTTGTTGACTGACTTAACAAAGCCTTACATTAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAGCTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAAAAATATTTGTTGATGGTGTTCCATTGTAGTTTCAACTGGATACCACTTCAGAGAAACTAGGTGTTGTACATAATCAGGATGTAAAGCTTACATAGCTCTAGACTTAGTTTTAGATTACTTGTGTATGCTGCTGACCCTGCTATGCGCTGCTTCTGGTAATCTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACCTTCCCATG ++ +)&#$398;<===OB:35;;;<5A>:987-.)DGFDF?301259:<>96=>;94%''%54;=959:@>ADG<::3&$*?@CIF<==JH;19864$''()'*<:?I=GHJDAC<>=;80'.01378+2>>8E7')5>B8<123=?>@=98=A984>>?JHMA;=C@A><),<9.567:7>:956===@E@99B-?4;89;;??FGK:=@A@BAD@B%?CCEDB<:?114+E==$&%3333:<6;A?MH<C43383.125<;;<22922DEEA357??JH;<D51=7716733*NBE?=E@:0+0=?C89<:DD11*4;*+9;:>/344:<8:>CD<?7<B43-+/,$&%02-.?=BBEB96>2A28:75:@@?8?FHC-...,/0+1)6459:<?CH4)8;?A2.*((1489:-;08>AB>AA?<B4?<CCDDEA=(129A@345054<A<3*A,'(1:CCAA/&3:677679;;DB?8842*(-%%''%,,&+&&$$$'$$%++)&% +@SRR11410539.2106460 2106460/1 +TCGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGAAATGGTGGTGCCCTCGTATGTTCCAGAAAACAGGTTCTTTTTAAAGTACTGTTGTTGTACCTCTAACACTCTTGGTAGTGATAAAGCTCTGGTAGTGTTATCAGTGCCAGAAAAGAGGAATAATTTTTCATGTTCGTTTAATCAATCTCCATTGGTTGCTCTTCATCTAATTGAGAATATTTATTCTCAGTTAGTGACTTAGATAAATTTTAATTATGAGGTTTATGATGTAGTAAGATTCCAAATGGAAACTTTAAAAGTCCTCATAATAATTAGTAATATCTCTGCTATAGTAACCTGAAAGTCAACGAGATGAAACATCTGTTGTCACGCCTGTACAAGCAAAGCAATATTGTCACTGCTACTGGAATGGTCTGTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTGAAC ++ +%#&&.44=EA:5@CD?=@::77&$-'(,;JFFIE8450;639244;=8@;>@@>?=@-)?@D@?=:..017-/$$&>7==<:/&''(+98,7-/%'&++).7?@;;;7+';<,)..+/,66'450)'*-093/+18:D?<?<?;@;C>@>?A>:=44*%(+(-D:BC1,>4BHEC45-=34,)-&),4;8:59IG9*8<?DD:5BD@?=7D@A:;F9@CC@+08E9?F<FF>71A5DFEDB>98,((@=>8;>C=:5;B:46:;;8911.5=:<364CBCEFE8;.*5:?>B?AAB?+,+&&*.,1A=<@<=@@./:<:8;>8CJC3/9:>:B0EAC=<><>9<DEHD<(,9@CBAC0:9???AEBBA<9/08B::7:26A5=5B=@3->8)B@=6;)('''/194>>@(?13.&:0::<;@:685AGDDDA>F895=978>CC@>8:5>;AEBC?;=A?GCAA=GEJ2;==;.'108@HIB884114;679978?:1(-%% +@SRR11410539.967465 967465/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAAAACTACAAACGGAATCGACAGCACCTTGTAACTGGACACATTGAGCCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAAGTAAGACTACTGATGTGCCGCCCATCTGACATTTAGACTGTACAGTGGCTACTTTGATGCAGGTTTGCCACCAGCACCCAACAATTTAATGTTGAGTTTGAACTCTGTACTATTCTTGAGGTAGAGATAGTCCTGTGAATTCATATGTCTAAACTCTGTGTGAAACTAGTAATCATAAACACCAAGAGTCAGTCTAAAGTAGCGGTTGAGTAAACAAAAGAAGGCCAAAGTAACAAAAATAGCCTAAGAAACAATAAACTAGCATTATACACTGAGTATATTACCAGTTATGAAGAAAATAGGGCAATACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTTAAAAACCTTAGCAATATAACT ++ +)3735466<9<K/=6:8;91.-,+,236,,5<?>11('(0../7;:?58>B;>>D@>AFBEE).;;;;806:@A+?;;=@>EB?:/4454:@?AEE@BEDA?>9&(#%),&&3475<?7;?@77*'%#%)%*/03<=64135;;:(:)'.$&&,::A;B>D489?>@BBDC?==6>@(1>899:HBA96$+5%DCBI?>@''.*'87>>?&&A:;9ECEF:=ABD?CBC67)+21;1&''85=@@:75($+,'$%$((366**00(6654H>>602%$()'$%#**)'%%$*'+/,''*%&*,/+,.01.1-%(+.');5=87.>4@BA@=8;99>C>447=@B:0@@,'&+)'*-,78=::222+-9>B<>>1>DAB>?>A@DE<==5&/-389CD@AB?6.-&%''$'-.0;<C=E>:6,**2(87>F<@:<AC>@>=;97889=<91&%047:&239:D8@?<9B;9<-*67*$&('&%)%)5'0$$%%-16.( 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+''($$$#$)$36=>%.%+8;DF8<<;A;D<1.(7CA9:'0./=?@C@:2=;=9)((1).63<=;;:8.?+:847211/-&#.99<?>@E9>6@/0;>?C7<=<6<$$-/0<?D=DB2?>?512//.78>93D77;1@A<=E:=CF=??7<B?DACD@?A7:EA??A<<0--3677;74<<<=;9685&7507&'=?@B621-&'9;@<?=2+5751<@05%%/355<AD;;;>>-8@DF66==;?E@:LH=:AA<=<;>9;566$%%#+DECGGIB@A3</51.0&,,2-6AAH@9B9:=5,'?,=>@>:<>99;>J5?EFBB===?<?@/224;:>>@6D527'1&->>1==5CA;5B;DEB=5000&&%'28<7?<;8-;7313*(=DBDB@>13'%$+566;EBC720)4)7<@GD?<JJEGA?A<FBBAGBBA:?+?5?BDFGDA=?=66'-5B63;<8@@89<@CAIFLA>779<8>A>AHIE;<;<99..+,$''$'%'%$# +@SRR11410539.1086220 1086220/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGGTAAGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAAGTTACACTTGTGTTCCTTTTGTTGCTGTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +&))%&%$%*&7D1@8>@CC=;<:4569<90+CEA::*:66=3@<>A@AAB:78;3=<>A<9A4?GC?7+7?4D/44DC?//5?@B9B>?@BH?6669789?B5>9::><:=;<ED@C=GF-046D?:>5>94EHACEBC<6DHG>CEE:81109>6F=>?IGCFFBDAA:1(&&).,@@>?GLBGFKD>A;7?B6DC6/+15<+6334::>111243=?:CBDGMIDAHDHI2)39<6<''&&29<@3,*1.@D664;;60522,168,'';;8:'2$&&%%/;=B1%?<E:..444A>?B>::80-AD;5256;GEB>=?@C>A@;E=DC>?=))4*+',533=?@=<2@B57C=9<=@:;<:;1&%:00:BEBGCI@MHAFFCDAC?BF@:;;1256;AHINF34+)(>>=>?;=CCEDDD<?;8CA8HGA@?,,-/5C:>1,:>6&&67<>C>:EBJG37=@>@ABA8:BCGD7=:13EAEBD=?A>@A<>;EAF<<D1)?<?BDAAA<;<ABC?69;@910611+(% +@SRR11410539.1433900 1433900/1 +TATTGTACTTCGTTTCAGTTACGTATTGCTAAGAAAATTAACAGGCGACTACAAACGGAATCGACAGCACCTAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAGCATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCTGAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAGCAGATGGTACATATGATTGAACGGTTCGTGTCTTTAGCTATAGATAACTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTTCATTTGTACTTACAATACATAAAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCCTGTGATAACACTTCAGGTATTGGGAACTGAGTTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTAGCAATACGTAAC ++ 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+TGATGTGCTTCATTCCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGAGCTATGAAGTACAATTATGAACCTCCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTGACTTCACTTTTAGTTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +#&%%$%%9;=7(8:)-2>BD??;B??A//,9:.C5;..'(./68FD>;86@BAB;>>D?<BD650?FDEFIGL@888:;JNDKMFC?LGDFECEEG<?4;,,47=7522A>@PKF?<6%-<BFDTCE<@ABG>>?D9A?AFDG?DRRHCC>9=@?,;%845053.)(*;?ABA?.):<=:9>%)??@;E?78@ABA@>?@?:1+666/3>4<<248@AAICC13ACDEE;?DFG=;@9<>==:;11;=@A>%798()*9;?8966%&77:>@=>;?FGCB=73<BBFF><8:>>ACB>=01&&'(-85;@F?%%&BB:<B8?)??EEB@IHIEBDC=>DDADDEB:5$9=<?A@AB:@CB.2(;@@37<<DEF*2IHA>HBHBA9:4AG'?DKEII=:9049<3=@C=E;;?;>@A9DC??><85+5?<@HB?=))/;98;=I;1:2:>=;:9''.0%$*022'AFFD@C>?KB=925/))%0+/865>===>$0:GFLDGEE=?=>A;<<@=B>:8:AG?BDECIBCE<1$* +@SRR11410539.1301140 1301140/1 +GTTGTACTTCGTTCAGTTACGTATTGCTGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAATAACACAAGACTTGGGTTTAGAAAATGTGGCTTTTAATGGTATAATAGGACACTTTGATGGACAACAGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCAGGCTAACAAACATTCGACAGTACAGAGATTGAAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAGATGCTCCAGCACATATATCTGGTGTTTGTTCTATGACTGACAAGGTGCTGTCGATTCCGTTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'()%%&(+.23C)-&:9=@C==;;:658$(36>@?2//)(415.55=<21#%%$'*.(/)+-566B760-,*+,-+89<>:=8;AONIBA>@/C@CDFA>>;9,,,<D<<8:==;68++$#$$,.=>=A89-$'+)74;074BI75-&&%4455002+.'$$#$#%&.)&$#%(5:7A=?E?HB0)32<>;4<?;>.';'*:;;:9ABJGFFCBC7D).95312299@AAFDD@D47<?@EDHHC9?6>?@E>::/+----/48>E;77A@@AC>?G?HF==ADDJHEGGG=92)'%%$$$)&.(*(1%#%$**+'*/)'%$$'$%'''>@@=?@A7C@A@7;79>157BCC=<DCC?BBCJDABEEAA>?=AD@9:/27@B:>/0.)(-27325-?<>@A;A@4+::<A:;@?<=HCHKB@:@DD;7DE;77055-###$+))8;69:=:@8-)'&(-2<=?A9=A88.2.3A0;CDA@C<6*)% +@SRR11410539.53203 53203/1 +CGACTGTACTTCGTTCAGTTACGTATTGCTAAGGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTCAGCTTCCAAGAAAGGACGAAGATGACAATTTAATTGATTCTTGCTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAAAATGTTTATAATTTACTTAAGGATTGTGTGTTCCAACAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCCACATATATCTAAATCAACGTCTTGCTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCAGTGATATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATAAATTATTTAAATAAAAAGGACTGGTATGATTTGTAGAAAACCCAGATGTCATTACGCGTATATGCGCTTAACCGTTGAACGTGGTGCTATGTTGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAG ++ +))**,'')./239=(<8<9<731411515;45&7DKDAC9/52<>::;98567&7,..03--,$'#*,./14-,*(%1>?)+-.6;@0-??1)+*3:>:54?@=BADCCD?>C?862$-7:DAEGIFE:;65:87A;C--0E=?A=89>A<87*+94(.&)*+*'#$*0;=>@CB91))/<=2C7EC/(),-1-$%'(+4415=<;98DB?JHE=?73;29:=@5282><@ECF@BB=?:5997'04.3--&'%#$%-611?:385:$:9>EB8898;A>8886139%5603:;>@;<>DD=)*'%&&'.)&%%+/#&*-2;?><<ABG-&8A.((113<9=77<;;B?@=A=HG@=;;0''6687:.$$$&1485?A=0((><4648@A@@=MJ,,5+*//>)8:8<:;5$#$$$,299;;7/((#%,#"%%&&(*&#&<;@>82%&*%#$%''$'-12768<CCJ>F=?<?:;=DDB@8@ADEMKJ>@CC>>>5(+# +@SRR11410539.1842478 1842478/1 +TGATATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGGAGCTAAGTTGTTTAACAAGCGTGTTTAAAGCTTGTGCATTTTGGTTGACCACATCTTGAAGTTTTCCAAAGTGCACTTGCTGTGGAAGAAAGTGAGTCTTGAATTTTGCCAATAGCACTAATGGGGTGGTTGGCAATCAATTTTGGTTCTCATAGAGAACATTCTGTGTAACTCAAGCCACCGGTAAACCTATAAGCCATTTGCATAGCAAATGGTATTTGCTCAGCACAGCACCTGCACCAAAGGTCCAACCAGAAGTGATTGTACCCGCTAACAGTGCAGAAGTGTATTGAGCAATCATTTCATCTGAGCAAAGGTGGCAAAACAGTAAGGCCGTTAAACTTTTGTGCACAAATGAGGTCTCTAGCAGCAATATCACCAAGGCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ 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+GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCACGGAGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAACAGGCAAACTGAGTTGGACGTGTGTTTCTCGTTGAAACCAGGGACAAGGCTCTCCATCTTACCTTTCGGTCACACCCGGACAAAACCTAGATGTGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCAGCCTGCAGAAGATAGACGAGAGTTACTCGTGTCAACGACAGTAATTAGTTATTAATTATACTGCGTGAGTGCACTAAGCATGCAGCCAGTGACAGCCACACAGATTTTAAAGTTCGTTTAGAGAACAGATCTACAAGAGATCGAAAGTTGGTTGGTGAGTGCTGAGTTCCGTTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$125?>>?A;AD.4,62-$?@CHGI>>B*+:DDA@AC;89<BAH@GK?HJC?9;<8569A726;9B@IBF?CKH=6844=;9<HFA>HFCC4B1:90&():*:>.4+59G9;0@=>;)90000@>-C>B=833431@?@E><901,0,*(./1/1/=;03267;;?:+=@D79B>AB@?B<2;@?;7440',&-65/=>>@BC?>C9=85:?;:89?@5>=C>D;>C5HA<C5<<<;**+*1000'8.-97/**@<>@ABFCD-.<2D>D?;44<;68;BFH9CD>EBC525,5,%2-(,(,+*$-64;<EEAAL71>%&99<913@;;:91BBA;9;454897(%78::>>?FIFC.=?II7>?@BHFFB;&,CEB6@0DB=>9GGEDMKN@FJ:>F?<<LM6C04EF<@..98=4319:64:=6>>>D6;EB9:D;+&,))'3)))*'&&(%'&,1<>>6.192*8?77??9;;:;:@=8:ACCE<@:03,* +@SRR11410539.712190 712190/1 +GTTGTACTTCGTTCAGTTACGTATTGCCTGAGTTAAACAGACGACTACAAAACGGAATCGACAGCACCTACTTTTGAAGAAGCTGCGCTGTGCACCTTTGTTAAATAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATGCTGGCTCTTTATAATAAGTACAAGTATTTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGTTGTATGGTACAGCAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTTACTGTCCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCAACTT ++ +&-0(,-;>A6=G0+$(.3374::<?65&/**<7@IMA;45569740()013'257665576,)&+-66@9>EESEAGJ@E:=FKDA=7=0?/.+-.-8F?JKCD@5--*39<88@?76,<><:LM@B>@>BGFDJ4B<C>?==8382<==A=9B@AFFE?BCD@81()1+1=A:C>95:68;579@@:@A<GFEDDA44*</201;CHFACCHE>440:@;=<5<A9?+78:66409><@CA;>D=AB9-.::7'-8=<:?AAC;=30?A9B43-&$7@?@ALJD@CDEEHF@@@C=E?99>@100+;CD/AAB>@7/<978>&?C=DHF>?QJA@E=:;B<>DFI>87IJFAFB?DH@@>?B939A=@ABEH/0;3+)(4+2>?A@<=60*'$'3-9::+++))-1,&=57?D94-%%)23A9==>FDG=?))@@A<2177434FAFDCA@=&&@11=7<4>BB<A<<JE>@9?;929===?;;=449:7...1-*-$'%%)%.$$**( +@SRR11410539.1602242 1602242/1 +CACGTCACTTCGTTCAGTTACGTATTGCTAGGTCCAAACAGACGACTACAAACGGAATCGACAGCACCTAGCAAAATATTGGACTGGGCTGACCTTACTAAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAATTAAACAGGGTGATGATTATGTGTACGCTTCACTTGCTGAATCCATCAAAGGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATTAATTTACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTTCATTTTAATACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGAGGACACATGTTAGACATGTATTCTGTTAATACACTTACTAATGATAACACTTCAAAGGTATTGGGAACCTGAGTTTTATGAGGCTAAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +#$$$$+$$)'09?4946C634298:;*(*)(''%%-1*;<;>CEHAF@@GFDD8:B?;<?F=;<D?@8?;889:9401478:,$&%'$$$((5645889GKD$7>E;:A85)*+,BEIG>C@<9?-.30*+.9@<911)''19=A-25<?C88ADAD?8/*%&*$+%&+,($#$$$%%''.56A/,;12(,3';,,.0+5<C?AAA:59?BAPI<>C>@C;8476,5.3587)+$%%(.41472&"$%.14457<=FH5>GC==D544<=278<9/1A=AK@>B;1JKH?995+&&01),7224:BE=4522.37:34<@FEC;442=B<<245;5786866227<A>>@:;9:.>2>EDE<A=EFB==;CFD73)'&%15/1/5*(&-&%&)5,,*(2676*-42$$#$$$#$$/0107=:86=:=-9@@,(;D@?A,7A:E?@?,+@BCKC=90-222.%%->79@(8;ACK;6:;GGM=D>?8:789%%,46<=:778@9:@?8=EB@14( +@SRR11410539.856880 856880/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAACCTTTCCACATACCGCAGACGGTACAATTTGTTTTAAGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGCATACTTACCTTTTAAGTCACAAAATCCGCTGCAGGATTTGGATGATCTATGTGGCAACGGCAGTACAGACAACACGATGCACCGCAAAGGATTCTTGATCCATATTGGCTTCCGGTGTAACTGTTATTGCCTGACAGTACCAGTGTGTGTACACAACATCTTAACACAATTGTTGATTGGTTGCCCCCACTAGCTAGATAATCTTTGTAAGCTTTGGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAAGCTTGTAGACGTACTGTGGCAAGGTGCTGTCGATTCCGTTTGTAGTCTTCTGTTTAACCTTAGCAATACGTAACT ++ 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+CTAATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGGCTGTTGGTGGGAATGTTTTGTATGCGTCAATATGCTTATTCAGCAAAATGACTTGATCTTTGAAATTTGGATCTTTGATAAATCAATTTGATGGCACCTGTGTGGTCAACCGTTCCAGGTGTGACTTCCATGCCAATGCGCGACATTCGAAGAACGCTGAAGCGCTGGGGGCAAATTGTGCAATTTGCGGCCAATGTTTGTAATCAGTTCCTTGTCTGATTAGTTCCTGGTCCCCAAAATTTCCTTGGGTTTGTTCTGGACCACGTCTGCCGAAAGCTTGTGTTACATTGTATGCTTGGTGGCAGTACGTTTTTGCCAGGCTTCTTAGAAGCACTCAGCAGCGGAAATTTCTTAGTGACAGTTTGGCCTTGTTGTTGTTGGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATAGCAATACGTAACT ++ 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+GACATGCTTCGTTCAGTTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAATTTTGTAATGATCATTTTGGGTGTTATTACCACAAAAGCAACAAAGTTAGGATGGAAAGTAGTTCGAGTTTATTCTAGTGCAGAATATTGCACTTTTGAATATGTCTCTCAGCCTTTCTATGGACCTTAGCGAAGGAAAACACAGGGTGTTCAAAATCTTAGGGAATTTATGTTTAAGAATATTGATGGTTATTTTAAAATATATTCCCAACACACGCCTAATAATTTAGTGCGTAGTGATCTCCTCGGTTTTCGGCTTTAGAACCATTGGTAAGGAGTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACCAGAAGTTATTTGACTCCTGGTGATTCTTCTTCTCAGGTTGGACAGCTGGTGATGCTGTCGATTCCGTTTGTAATTCGTCTGTTTCTTCCAGCAATACGTAAC ++ +&#%&''/02.:A/($+,-(*0+/:,,++9:GHE<55916/27=8CD98*,295740.*011772@@@AEB?++*+--+%07<=I@379==2,%&)&01)+,-*'$%)*.<<496,$)(()$(*.%*$%&.0+$$)9==8;,;(%9</2''$%%%),$(')----2)662.26:9/17=/<>?>,+&,269>6997''&.)78:9A?,%)*+)$&%$%+58<>?6632.17780?>0&&')))$%,-AAC@;/-8+/+*%)**)588@>>>?A=(*&$%%'..5311.&'(-..:48/6-.(*.(*%'79>3:73#'6<DB>;<;>?.2'&)59==>/1.%)$$$7=C<>:23(0&/41/1)-56/===?:9=EBA;./):AB@9;>?99>>8,'.+*,-</1(029;23>-85*-.%$%)&%3/0)*#(($&'2$'(%&%#.)*'.,:53A?:=B889&04::8*.))(/998<99650%&%(,(&)68>?7)+%)& +@SRR11410539.1842263 1842263/1 +TGTTGTACTTCGTTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACTGATTAGGAATTGCTATGTGAGATTAAAGTTAGCACACATCTACTTGCTATGTAGTTACGAGAATTCATTCTGCACAAGTGAATATATATCGTAAACGGAAAAGCGAAAACGTTTATATAGCCCATCTGCCTTGTGTGGTCTGCATGAGTTTAGGCCTGAGTTGAGTCAGCACTGCTCATGGATTGTTGCAATTGTTTGGAGAAATCATCCAAATCTGCAGCAGGAAGAAGAGTCACAGTTTGCTGTTTCTTCTGTCTCTGCGGTAAGGCTTGAGTTTCATCAGCCTTCTTCTTTTGTCCTTTTTAGGCTCTGTTGGTGGGAATGTTTTGTATGCGTCAATATGCTTATTCAGCAAAATGACTTGATCTTTGAAATTTGGATCTTTGTCATCAAGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +#$#%&**--.&)(5=82.>:>7>7EC?E8+112;BJFAD76-.1)57<?=9=>=61366024/1&&''/0/.2<8C=>DAG67,/+67='&9568:A9>>ECEF/9/10&'$'&.5;B=96692?C=<389BB@9;9722588@@@?BB<=7800+7**-097;=A;=?@>@,31233-*''$%/>BH@JG>;6,)''#(/3578B@@DD.13,9><?944,8>3;37=:>A???<=;=<;84/761=;;<=>@9446:5BB=DG2@@@<@629;().(())>BC%%?66612.,2-41/<;?EC:704C9>@85CEAF.,FB@BC=BABC==@DAC78&/7:;<+(((+&9/?5=0.34,44?@:E?;?>FD=55A?CDB4199:5>>?DC=>><?7?734@AF<31.10/,-<@E=?<2''*>B82<49BCAD;:B9:8><8:JH?;97>?CH45/(''?G@>A<6A*+9+9=56628=@=KA<>6BAH=;C?<>;:<335:=:95320.+:BC>>D?>--* +@SRR11410539.2039774 2039774/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAAAACGGAATCGACAGCACCTGGCACATGGCTTTGAGGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTATCCGTTTATGATTGATGTTCAACAATGGGGTTTGAGTAACCTACAAAGCAACCATGATCTGTCAAGTCCTTAGTATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTATTTGAAGTGCTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAGGTTCAACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +'+-231:>8;=HF0,<22.?<F?BE=06-16INHDG7@44=<<59865<=;;4=;=9=:>>DA=DAC?9=/25379F==5777:2$A-2A<8555//-)'%%3645GG@9=>BE?8:9?:12'&&*/,0177C:CE879>>:<EB@CA@FBAF=3.+3@=7..3E?66,+704749./;?289:@>A=;<444450@;@=;;5&&##"$+/:@A70?@AOFB>EAFEE67BEHF=>@B?9,)%%+7;CAAC=DDC<9%&@@?>:5.3.%6?*+-..3++'+*5<=CC@FBD@>@C9;??B@>@AHD>>A@B?@??:7;2.>72:12--+&+,-65-7@'&FELH>>65/D9CC=<8;790,,*)-4/<CD99<9C@0104BDBAAHIHL?@FG9)GIHCD=@><B88611;1=9%@;2601505;=8639:BBDL?;<8><='./657:?CBB:<<?@>;:;;4257<AHC@33$$ +@SRR11410539.1476200 1476200/1 +CATATTTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTAAAACGGAATCGACAGCACCTTGGTGAGATACAGTCATGTAGTTGCCTTTAATACACTTGTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATCGAGTGGATGGTTATGTTCCTAGTACCTTTCTGGATAACAATTAGCCATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAAGTGTGGCTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCGCTGTGCACCTTTTGTTAAATAAAGTTGCGTAGTGATGTGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTATGCAGTAAC ++ +/*((''&46:<=<:=8;7123/.56>955*(::<;>;>879-6'0+9;731'*%254;<<29?B@?;<9==;7-=>@?9:89CBC;;;A?<687:7**.&&../0$)$%$(;970<;9:BGBC87'$3*86::=:9:255>;@;1113=803=>=<:9;&'+'%9EB?@=43,-,,047::5542,),.:=<?<=E@7858<?<=86<<@887651.,*,'+''&1&728;>?039=;;;5.&'%(-,-00/38?7:;><6/2,,+*%#$$(2::9999;050:;@:<@>ED;2<:;E0>6A@B7:IDBBB:479++27=>29==,(+:6;0.)/2552/+,16:<>AF=@49+%0012<6:1:7,=C?>2$,+9'@<=58967:>AB@;=44,739=A@FB0<,832301:;6:0?BB>==<@EFNA>?;ABG:9C><A<;A=?B=.-%%.%-+',' +@SRR11410539.1526595 1526595/1 +CATTGCCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACCAAAAACGGAATCGACCTGGCACCTGGAATTTGGTTTTGCTACTATATCTCCAGCCTGAAGAAGAGCAAGAAGAAGATTAGTTAGATGATGATAGTCAACAAACTGTTGGTCAACTAGCAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAGCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTGCAGCAAAGCATGGAGGAGGTGTTAATTGTGAGGCCTTAAATAAGGCTACTAGCAATGCCATGCAAGGATTGAATCTGATGAAGGTGCTGTCGGTTTGTAGTCGTCTGTTTAACATAGCAACGCTAACA ++ +*&&&(*,*.38E74.4:??B8<8>?ADD:98FSIFG-.)/);?@@8/'601/76549<?606(#&&(%%(;;B:<2)-..((+,,+%$'%#$#$#&')%420AAEDDC1;95;A279@C80>2*8:;*4EEA<B@43$$=AD>7D9:C;>*9ECMLBE<>()'()()4.;,9:<14?>?<CC=:C=@65?;//<=B?9<>7DBA65'*&*(:>@5;AH4+9$./?>??C>A42:A@A:@9D@7A:>DAFED?A&:23.4/226<A=4>?:>4/@EEMC;;A67CLFLJC=?=,))*>>BGB>=A>=?C@?::;=AC<:6***%&'.*+-1;@A79&'&)+.=><.&&*/BDHC;<$&%&-6-0$(559>@?C62GJD=<%/DC:#%#$$'%%$)/*,.8/.4/483&(%%&/#$$$&9;AFD=>2556CB@A?90<'::;9-%&7511)*(=*;ACCA4@8<:<45020&8<A?65%%0250-(,1.')6.-454561%*3,.&&%(%(&&(& +@SRR11410539.511920 511920/1 +CGGTATTGCTCGTTCAGTTACGTATTGCTGGGATGAACGGAGCGACTACAAGCAGAATCGACAGCACCTGGCTTTTATGAAAACGAGAGTTGACATCTATGAGAGAATATTTTTGTGAAGAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTCACTGCCTTTCCGGAACACATATGCCTGTTGGCATCATTCTGTGGGTTTGATTGCGTCTATAATCCGTTTATGATTGATGTTCAACAATAGGGTTTGGGTAACCTACAAAGCAGCCATGATCTGTATTGTCAAGTCCACATGGTAATACATGTAGCTAGTTGTGTCTAATCATGACTGAGTGTCTAGCTGATCCCTTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCATGTGGTGATGAACTGAAAGATAATGCCTGGCTTGTAGAAAGGTTCAACGGAATTGCTGTCGATTCCGTTTGTAGTCTGTTTAATAACCAATATCGCT ++ 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+$02*,(;<==<MD$*$*?>C=:;;89@AB447DHEHL?798?476669:78-/(*))99@DD?B@B:D>>/3CDCB?>?C>=HA685;DDFC@BCCDHE?B=?CGL@<DB15@20988<;82+?74?BGQ=&5H<FDHGKC?CJ<C=>9?7>=;851.1339?CCD?B?96GA/1;@DLJHE@<GBDIGABGDCFCC878;&&@>=<HHRL@HB:>H:=:9;GGCC@<@@=A?7D@BD?:5-2)%')()())>>C80/1&(+,,)#%((:9A771255@=<<B711/<@B::6-E3B;=8?((><>EH?49><<<;<===<;D;06(+.2>@I22@<:;8<9=<>@B9+:=BE4:?A>DEF>@?KK=B@E<HB:=>@@:69-,0032)6=B@ASOMF.B8./.'6629FF@@<:<CCDCA@9=8+:;B;*34379B7,)#%%&8;'<???;45$,17<=@>D448624C=<CFEDF>A>IHKHECC;?A=>?D@?<;;4325'&($%#'&'%,.1/( +@SRR11410539.715925 715925/1 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+&+-2.,0042..-'%)&)$$*23--())'))%$%&&$).08;84/*4:@A>;9;11+)'0*436511?7=CG78;A>CDDD>A;5+-)&'%'%%).)$#%'-58DG.*=<23A>51../;=BD55C6+;))+0189ACAC@EDDIIKOH?9B<CCA@GFCD.%%$'&&%%(.,&(%(--..)*+%$&(((*)#$'56<;887/(&'&*5'/1=?F=1;2AEADB=9=>?/039911-<;:70/$+$-3+)'*3=>DA8=IF=;G:97;@<99;<B@GACG@;A:/GIF87EH@>;=?<4*))*:>A;=:;615@B<==CD@=A=?BG?B;=<1889;;8F><45>4312,*><467988/)),0645.'%++%,)%$%$)+022;49@:6>=@B1A;;9:33/%&12272)6//;<>A>B?@95CD>B6889<BCDBCGKFME@98-?BC;?4,B?9159620-A:;9FEK9==8574.3=<=B6@A<CF@>7BBB?@@B@53, +@SRR11410539.1031143 1031143/1 +CAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCACAACTTGCGTGTGGAGGTTAATGTTGTCTACTGTTGTAAACACCTTAATAGTCCTCACTTCTCTCAAAGAAAAGAAGTGTGTGTCTTAAGATTGTCAAGGTGACTAACTTCACCATCTAGGTGGAATATTGGTAGGATTACTAGTGTATATACACTTTTATCCTCTCTTAAGAAATTCTATACCTAGTTATTGTAGATTGTCCAGAATAGGACCAATCTTTATAGGAACCAGCAAGTGAGATGGTTTCAATAAAATGTTCTTCAGGTGTTTAGAAGAAGAAGTAAGATAACCATTATACGCTGTAACAGCATCAGGTGAAGAAACAGAAACTGTAGCTGGCACTTTTGAGAGATCTCATATACCGAGCAGCTTCTTCCAAATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACAACTC ++ +/()*...;;=>CD8>8>?=<63GCEF::A//AGHEHL<@>>E>=89966880./2687.>F9G5A@=<I:6089ADF=:<ACA@D7<>-,)0?BF@+1:7I9:DFGDECDC=CCB@@>ACGD9:;>9=67:EG=;?FF/-:93+'=8@C='D&F@DB<()4$$,.(.77&)9--&266028('''(66<7?9;),44---18;BB<<6CC:<8>6A5(01+(4<==BEG@:%%(89C<=8'(**+226>8>9=928123/$$(:;:;64;@--=66.:<>=D<>==>89DE@A74>7?:8<F64;<<AGABD=;=<=IA885=?5H<?@?:G4>@9@9<@AEBA=,7-)&('-489<CDCC;=<DFG?2A)(<BCHKB@?B?98247AD?>)BD=?43CEG>@A@HLFA<@B>>BEE><9(--+67784=/**@@>/GDHE;;DAQE0=F>::94:<:=>A?9?@@K@AB9D@A4235.:79989./*$%$)$%((0)'$+& +@SRR11410539.1943800 1943800/1 +CATTATTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAGACGACTAAACGGAATCGACAGCACCTAATACAAGCACCAAGGTCACGGGGTGTCATGTTTTCAACTTTGTTATAGGTGAGCATATGGATTATTACAACTATCGCCAGTAGCTTCTATGTCAGATTTGATGTAGCTGACAATTTAAGACATTCAACAACATCTTTAGTTTCTACATCTGAATCAACAAACCCTTGCCGAGCTGCTGAAATAAAAGTAGATAAGACATTGTCTAAGGACACATTCTTTGCAAGTTCAGCTTCTGCAGTTGCAACTAGTGTTTTGAGTTTTTCCATTGGTACGTTAAAAGTTGATGAAAACGTATTAGCGTAAAGCATCAAACATTTTAACTGCAACTTCCGCGCACTATCACCAACATCAGACACTAATGCCTGATCTAGTAACAGTATAGGTTGACACATAAGCTGACTGTAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATAGCAATACGTAACT ++ +&$'(%%.)56:;<S7/9>CB5B?HH@HDBEAA7B@=//.)#*&7*;'1(69<?69==6>?:*%:?CF7G?ACGFBC@CFB?E@9K@EBB9=D9DF;>BAEDAH5733))@C=98898?;;553:?E>;)/(:8.'04737$9?;=;:4,;1G%%%(AAE<.%715/())262.(''&19868;98445;1::<=>=80:;GGCDCA3,8,-=;39>3=B=A:75@11?BEED>>>A>A><:78E:;@A>DF?CD6.3;A5E@?A<BA88:64>9@@8F;7':=7788<92@9:=A;I@BDB?A952)>),(3005377>??:<;;9DIERKH;>55957BC6>CB66'()C>@A9115GC46A>?24&,)**+)37934-09CBEFQEA;5JIB92,?@>A7%)*>?3:ADBF@CBH2@A11D<?AEGIC<CA=2,5C@=<B@@94:?@7:7=6:CDA7B><775??B@C:034AAJJBAHBBA<DCEC>468?AE;4147=>?@?B@@D<0=%?B:>CDAEB;9&&#% +@SRR11410539.2287969 2287969/1 +CAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAACTGACTACAAACGGAATCGACAGCGCTGGTGTCTGCAATTCATAGCTCTTTTCAGAACGTTCCGTATTGCCAAGCAATTTCATGCTCATGTTCGGCAACGGTAACACACCCTCTTGTAGTGTCAATAAAGTCCAGTTGTTCGGACAAAGTGCATGAAGCTTTACCAGCACGTGCTAGAAGGTCTTTAATGCACTCAAGAGGGTAGCCATCGAGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCCTCCGTTAAGCTCACGCATGAGTTCACGGGTAACACCACTGCTATGTTTAGTGTTCCAGTTTTTCTTGAAAATCACTTCATAAGGATCAGTGCCAAGCTCGTCCTTTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCACCAGCTCCTTTATTACCGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +)$&$)/-9@A?>I54/0=@><:B==A===**68>A<@=;**2((@<<9+412-314-79;@<,-+($)/%)19@C@EECE@DEB=;CEC?<:>53753+)%.,('&*%++-,0466ADEFK?B:BDBDEFAD@@+23@&'6'-2#$$%(68902>:8))48D:4CEF<CE93))?7EEG?FB5+089BC<3<5<3>B<<>==@LIECHB@B<AHFDHA?F6.@=A>A?FI@B@HG8=()68I34442::.)6$')?@>D<9533B9;?9:E;@CHE=>?;;:/AB?88,,97@@@=C4HE@AGADC5//BDAD>C=2.*&+22289CCC@>;?00@A@ADE=8:@B@:.54>45;77(**22=82'%#&47A<=BG6F5+>49IAGEBB:B@@<&&.&((121)?77&6?A>?B=A=A<B3:CB<=@9B=9@DA9=<994/+8>?5<DGE@DC;;5-)>ACDIC?ADFGDBF@JF=/6>A>@@=AF?>@G>?;:9:HBEFIDA8:8$&& +@SRR11410539.716146 716146/1 +CATTTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTTGAGAGCAAAATTCATGAGGTCCTTTAGTAAGGTCAGTCTCAGTCCAACATTTTGCTTCGAGGTGCTAAAAACATTGTTTTGATAATAAAGAACTGACTTAAAGTTCTTTATGCTGTAGCCACTAGACGAGAATGCATAAGTGCTATTGAAACACACAACAGCATCGTCGAAGTATCATCATTGAGAAATGTTTACGCAAATATGCGTAAAACTCATTCACAAAGTCTGTGTCAACATCTCTATTTCTATAGAGACACTCATAAAGTCTGTGTTGTAAATTGCGGACATACTTATCGGCAATTTTGTTACCATCAGTAGATAAAGGTGCATTAACATTGGCCGTGACGAAGCGACCGATGTTAAAAACACTATTAGCATAAGCAGTTGTGGCATCTCCTGATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +$#%%#(/=D7-&866@B=BGEG;;?--/<:9<A9;;8A;CD:>96*+*//34476>@;6:;ADAKEGCFE=98:AA=-8;>:993*579=ENGCAB'(73-=580626/000E==D>?FRK4=F/+($,,+$#*6:;4,?GLK?DEPGDGFFLCIQO,FJ@DICAGCJK68DEBOKB<##'2&&6778@=@>;,&'$$$)$(,42;=<HAA<47-))+-&*-9:?@C=JIB=B84=003@AF=CC?>8:;DCA;GH:<@@BHA>FBC=?F=?=77<?AE=FH>B@;BDIHD=;=>=-B>A44<B>AE?HEHGH@@B69.;0A<=B@:,,>B31<@84>6EHA=@<@FMC@CDDE==>>DHEBB66:4736CH9JIC=?62B9;@F=?<@B*(#7./6?B@@IBFG?;??=ED>((%%%%/+)*%(-8@D77,:<=:;<;=<599<7+,*1-378+7>BDD?CF$'GD90>+2=>@?C?:33,-1#%##'A&266<2:4@6:BBCBBCBIFI<>BCA@EG@-1& +@SRR11410539.1105915 1105915/1 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+TGTTGAGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCACAACTTGCGTGTGGAGGTTAATGTTGTCTACTGTTGTAAACACCTTAATAGTCCTCACTTCTCTCAAAGAAAGAAGTGTCTTAAGATTGTCAAAGGTGATAACTTCACCATCCCTAGGTGGAATGTGGTAGGATTACTAGTGTAATATACACTTTTATCACCTCTCTTAGAAATTCTATACCTAGTTGTGTAGATTGTCCAGAATAGGACCAATCTTTATAGGAACAGCAAGTGAGATGGTTTCAATAAAATGTTCTTCAGGTGTTTAAGAAGAAAGTAAGATAGCCATTATACGCTGTAACAGCATCAGGTGAAGAAACAGAAACTGTAGCTGGCACTTTGAGAGATCTCATATACCGAGCAGCTTCTTCCAAAATTGGGATTGCTGTCTCCGATTCCTTGTAGTCGTCTGTTTAACCGCTAAGCAATACATAA ++ +#&&&$#&'-5<>8:B=921DHD9:>B=?>@>;/4;C@8=?5161<AABEB=<958682=;<9=;F?ACB@KACABB=>=:96<8.+/3?CEC:;44=A:=BDH>C@@C=<>@C@=ACBB9;6:822668><ACCA%8>GH6&@A21<5;><1987BDC55=,&;?@*/8=:@G=<676+**+>)),(88756)*)5*+4/106,5+'*')/**823AB;6//4/345:;-&8'((727:0+:$;:<<>@BA?@EBBAA@A:@88<54:@?:;:9/89;996<5877<=??:?>G?F=/4<.BA@;<;<;FC:=DGED<=<AC?D<<@?>?;2;1=>>:;7)*'-+%''$&255,921/99678;;<?C783CEF@:JG1+<54458;<968*,&$&9(9:;67=;=:=?>::;/-,%(2==BA?@?CCEHD==931,##*$$%(,(((''/),+**2;;=,$'%(++%55&'%(*&21/+&:@<?AA<50)*%%'')$/**))*++$) +@SRR11410539.946267 946267/1 +CATTGATACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACAGCGACTACAAACAGATCGATAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAGCTGTATTCTTTCTTATTGCTTTGCTGTAGATGCTGCTAGAAACACCGCCACAAAGATTGTGGCATCCTGTGGTGAGTTGTTTTGTGTGCTAATTGTGTTAAGATGTTGTGTACGCGCTGAGTACACTGGTCGGGCAGTTACACCGGAAGCCAATATGGTCAAAGAATCCTTTGGTGGTGCATCATGTTGTTTGTCTGTACTGCCGTTGCCACATAGATCATCAAATCTAAAGGATTTCGAACTTAAAGGTAAGTATGTAAATACTACAACTTGTGCTAATGACCACGTGCGGTTTAGCAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGATGGAAATTGCTGTCGATTCCGTTTGTAATTCGTCTGTTTAACCTTAGCAATGCAA ++ +($#$%$$$$%(/8C7708<>7A<FEDFAACCB+?HIFG65''-,%##'+363<>@60-'(1./%&').3-//0366(592?<?=::1+4004('(&()*/.+//3('..<B;83''6<>>.901*,*($##($$&0/-,%%('&().%$(,..//2*#$'+*0&''%$10/,,,-.55+(&&/3'%&&,%%/#$%%+(-%(###)-34&)47668:3AF7/;FB4):>>4@?(6)'%)$$&,--'-2+(+42;5.5#%&./5892084226789,,56:<80,)3-,$+/323935757C688,7114'&&-.&.192777>;:;?4<1+*/$-/&'-4<::7:/)=--+(=+>?*$7'/1+#$%'##$/0&%()%&$&,%%#)-0+-('%,)*'''''.16565<95.'($&%"048;.%$%-.-**$((,493043<=;<?<:;3346+,1+.()#&%%+$%$%$$*+)6-*012?<12*&*A01$&#'$$67=<577:;B??;;5877)((%' +@SRR11410539.415291 415291/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCACGGAACACTTTTACAAGACTTCAGGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAAGTGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACAAGGTGCTGGTGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGA ++ +$*,,8877965<:-7;GE98::>7:356%&5?>;CF:2;6=A::72+064*1&).<<=C>;6BDA@>7722,*$(,/481121<7:<DEBFCJJCHFECG:65.*''+49861..'(-/18>AD?DHLEA@=><:BJC3A.%29=@9@3<;9.%$&.28:::9@C<=GE=@FIE=::74>ABC;;HI?@?@AEJAFD+;+0-0;+19B;==9=DCCF?B@C?@D??=89;@::85:?;1)<JJA27IIBB=@7;C@AA?BC9879??F>A?6-178:968;?9++9--,?C@GD8;66?A83=7....*3**46)/8:7?@275632110356'<<79611,1)%%:8:DE9//138@BA9:<??77A>A>?A<=::=<<97;1>=44;>?>C:4@<CHB@73:6>?0)&(.&%:+4/)'*./,8678971ADD>A67CE><75=BCCFADE44CB>GE(;:=95,-)-+,1*,7>AH9=?=99241)(-06:;8:824'+**)'&&$ +@SRR11410539.1714375 1714375/1 +TATGTTGTACTTCGTTCAGTTACGTATTGCTAAGGGTTAAACAGACGACTACAAAGGATCCCGACAGCACCTTGATTTGAGTGTTGTCAGCGCAGGAATTACGTGCTAAGCACTATGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAAAGACCCAGAATATTTCAATTCCCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTATCACTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACACATAAAGACAAATCAGCTCTAATGCTTTAAAATGTTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACCGCGTAACCCTGCCGGGAAAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACGTAAC ++ +##'+46,/(0024>K,2)AA@:<@><3238:()52.1:;@34/C>A?GAEC>76*.+2&&:2>?5>-@H=>CFBDGE,21*E<17.%(&%$$/&-'$%%+')$''65<>:AD?CA/0>@A339-7?>@MPIJCC:=4545)''(*8;@BC=;CBBABD:8/?A?@AB.:<:?8C9:%&$(&(**.1(?;<GG@B>>9:%-*38>B@?9&&48=355//4BD?BA0.6;''@<>=A<:=IF?@,@;BFD()A=7?4:>;@1&$2$#156?;8?KJM=EGFIB9:;07--BFC''(A<@@CC==:939::22.))*<??9995-),3;<3/;>BCB836(*-2%---.//04;>=C55<?CBDAB78<409.;=82300<=BGGFCB@DKAC@EFCBA@?G@D=&/&=?AACCC:;9@DBI6>@78>AF15;<8;670((#$%''+76()%$%).&&,*'+/9;???<6BDFNG=@?FCA9=4548-*=0714$$#$#&()*++*+-.+()& +@SRR11410539.582859 582859/1 +CGGTGTACTTCGTTCCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTGTTAAATAAAAATGTATCTAAAGTTGCGTAGTGATATTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTTAGTGGAGCAATGGATACAACTAGCTACAAGAAGCTGCTTATTTACATCATCTCATAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAAGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTGGTTACTGTCCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAACTACATCAACTTC ++ +(#&+%%$,3697@?$*%<<=7AC1?AC=<:A@'2AIGILB@22<;CD?DHB;>68+/*36=<=)2+;<A>CB=BCF?(*=6LC7AE:3;8:68&$#$%&*37:@AEHB:?A))0//39;D=EH3?18>?CBG;H:1(&&)<=?898-79?;BCB?>?449=5<?AGFD2.+++-.@C>DBGDECDB236BH@>?AEEDFFDA@9B=?:,:BC=:;CB?<-.>0=$$0-.7&120866623-$4/-#$&*<@=>B=.-78'.2%+:3CDFCED?L>3=,)39;0?@;6:>@BFGFBF@9:7121368?=?<<4102&>?9DA:6<=<=;@>EA@FA@=A89BB<AB?BFFP861>2JGIKDDG<=?>>E<@HA:?ACF0471+)&%+(%%)$(,6<<BC@E=4,.46>EH@@?778616)(),-,9899;FEC7:1C@/.2%'123'*DFD@?=--<**)=C<A=;:?A@BC<=./?F3;57<>9<=>A;=7445621.+-('#%#%*+,&&$$$# +@SRR11410539.2126554 2126554/1 +GTTAGCGTTCAGTTACATGTTAACTGGGTTAAACAGACGACTACCGACGGAATCGACAGCACCTAGCAAAATGTTGGACTGAGACGGCCTTATAAAGGACCTCGCTAGTTTTGCTCTCCGGCATGGATTAAACAGGGTGAAGTGATTATGTGTACCTTCCTTTTAGATCCGTCAAAGATCCTAGGGCCACAGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTTTCTCTCGATTGAACAGTTCGATGTCTTTAGCTATAGATGCTTACCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTTATGCTTACAATGCATAGAAAGCTACATGATGAGTTAACAGGACACGTATTAGACAATGTATTCTGTTATGCTTACTAATGTACTTCAAAGTCGCCCCAGGAACCTGATTTTATGAGGCTAAATTTCGATTCCGTTTGTAGTCGTCTCTTTAACCTTAGCAATACGTAAC ++ +((+,/59?/,%&)069%%$'($%'+#$)22<>;?56=76.)+&$&$/./12?<=<@6;4A??1;3=A685C?@:=;@?86227,%%&,-*+%*01)4;7.851&%%&'%(DB1+.78$<*+($)%&'%*#%&/*2))44,'$-%%&,...,)((0112$/6788:8@771$,+%)((<78>640&)00#,)-7@3@AF@1694702*&'&%$(),'78A=@EB6454,7568;3/1-&%$(.0))4)%<(1,$$0(66;=5.17.<;98;6'#/4136/.67<89=>:=;,,.@?@;<686+3@:''.-/.=:;@FF==8:984/('234:8=>$#0+,*-876C=91(,4/.:2145754227<B=<3*))')$%+&$$%'-268@:2<;655((,0&6.'$$$)%&)+*+%&)%&&&'&(2504935,&,0F9..,0%***$'(()*/0,77(*-479,21577033+&---779=96,.723762-.''% 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+$'+&9AD??MC5*+;;/45>==?9?1/04CGHFJ@@>AA::20*55?@?;491::;>::>6:677<0:AC9:7/.4==%+%%3$%.%)$%9;;<;D@AA747A223BC<66274&,&&0073#)CCEBE?7=<9DBFDBBDHHA240<=B6:59633.,1&37;:;BB9AB?A@@CI>@@D;1129450>?BA7;9>>DCLE@=;<<<343533,)-37;8@H@58@AB@CDIFEEGDA@A@DBE8748:;7$$&&);D?><>&$?9:AEECHLLJ>7D59HB>@=>EAC@8*&&&$%9481//8<=DE>C7<:;D?DEKIE@B<;$))))***11G>>>DC5<918;::=>815;=:@?;66021A??BEKGD7*3+')2>:7=D757:<:;A>8A2:6??D77L>>EHE:<FEIEEE@DCE?=AC@<G<'5(8::>FD>@=*?93?:55=4;>>.AFFFA@<A<<@;'*)**(%&'48<<@?A99=10*-*,6))++,0A=<61$&& +@SRR11410539.2346994 2346994/1 +CATTGTACTTCGTTCATTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGGTCTTCCTTGCCATGTTGAGTGAGAGCGGTGAACCAAGACAGTATTATTGGGTAAACCTTGGGGCGACGTTGTTTTGATCACTTTTTCGTTCTCTCCATTCTGGTTACTGCCAGTTGAATCTGGTCCGCAAACGTAATGCGGGGTGCATTTCGCTGATTTTGGGGTCCATTATCAGACATTTAGTTGTTCGTTTAGGTAAAAACAACACAGGCTGATCATGATACTCTAAAAGTCTTCATAGAACAACGCACTACAAGACTACCCAATTTAGGTTCCTGGCAATTAATTGTAAAAGGTAAACGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAGGTGCTGTCGATTCCGTTTGTAATCGTCTGTTGTTGCCCAGCAATACGTAAC ++ +1-/00309;79:C/1&),(-&&&%(.7:()BBGCAC9843:5;;9610:8+3%'*,9?;943021-+,%'2$$77?DG=CCF>A<5,,-;=9($&<?AB=?;9>=<7,+%%*-&*))+(+1../%$4$$#'.&$'+56=A=C><2,''4##$')))'.++'/.47=AD:>87:9<5881$3*,.400//5+&*'&.'56:=>=<=>CC@8==9=9?>>B<==;?C?IGE>(,,>782**..,(%&&1.59,#),1%,48:<9,')%&%&%*5:962:.&((#$))56/*&%&$#'/,EG>12=?E@<9382/.4.3845<;:5+;<?5*BFF>@DEEG<8:DIA04@DE><9+8887;>:7:1$*:FHL<>...=;>?>CE@A?8,4;6088=;55DACCCDIFHC8<C>?<EE8B7@D>7;39;)1+,(#(*248*@?EA@B8A?2+-,,'-'39548,#$%##$$&#$#$#"%$'$'& +@SRR11410539.2012668 2012668/1 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+CGGTAGCGCTGATTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAGAATCGACAGCACCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGGAGACTCCGTGGAGGAGGTCTTATCGAAGGCCGCGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCGAGGCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACGCGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGACTTACCGCAGGTTCTTCTTCGTAAAGAACGGTAATAAAGACTGGTGGCCATAGTTACGGCGCGGTCCCAGTCATTTGACTTAGGCGACGGAAAAAAGCTGATCCTTTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +.(.-,(+'()&$--($(&($4.?;DA9:<''0@ID?B&>22?B972.(&()$(''-389></7+84@?E=3/:@D>@B?DE7?<;<D;*%:,%//&/2207/0$$%&%*'#*#$+,//4/1,01,66.0)0524%%*()$+#-*./%'0),138::1.(/$%'**4542;>;;:26<;4(%%(+408=;RO=,2;@GJGF=0565>2*$55;;C7<0><8+=9:CGGE@@?BAB86;:0=/3:6*&,68/=<=AA?<=>?6@<C=DDCEDBEC?C>>EBG@@;>=98*'#*.+-*136102-1*+*&8294@:979;79/7)%/,++&'<78<@<A@:;><01)')(*,)8%%.80(3-#''+$(((048&(%+>D:76<>GD2259:'+01012?<A;HK;6%)&&)-((&'%-.;6/'**+5&'&(%%*&$$07,--.?<;<<?;?=?:7+-*%)(''$#'2*%4$#$&%03>;99/68@A?G:;6;:A<==80=7=@AE?>C@A>??A===?ABFE>=62%% +@SRR11410539.502390 502390/1 +CAAAATTGTACTTCGTTCAGTTACGTACTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACCGCCTGGTTGTTACTCACAATTTTGACTTCGCTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTTCTTTTTTTGTATGAAAATGCCTTTTTACCTTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACTATAGACATGCATTTCTCTGTTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAAGTGTGGACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCTGCCAACTCTTCACTA ++ +/&'%$%*')',284:C2+&8A@=5),%-=561FNJHK56;=>@DA><5(;;;5')%*45520+..5::F>;>>=74#$$(-35:-2==>FBBEFC9=;=A?----$&:;=;3;38JD>>$$/G(5FKFIDAGHA<715DGG9BC6%7;<=88DBFC@ACMHFCD<<BBRJCD=@FIRKNABHEB/4/4112./1AC<C<A;=C88CDTGBA<?:=<FAAC@/)><=<%%9.4)'--<ADCFGL>AEC?B>JH;@;GFG:DD>=??><<=MH===DBHF9?7ADEEGEKD66DDA?<48=C@B>@BBIA?=A?EDADFDHD>04;>9AC@CFF?AC?BOH67<9AD9=GHFED@C=F:=?@8:B?<=HHRE;<:A@HK5868?;:?=<>@CEE=@E?7@;9777-)-:7+,34>?B227.45CGJCE=@5F9HC;=BCGFDDB@FBAA66>B?<885$&%)+*=>E4;2=ADB@A<CCGMB?>;@@HC>=917*.552,,'%$&(##$&'$&&'*5%$/% +@SRR11410539.336997 336997/1 +TATTTTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACCACAAACAGATCGACAGCACCTGGTGTTGTTGGAGAAGGTTTTTCGAAGGTCTTAATGACAACCTTCTTGAAATACTCAAAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTCTGCTTCTAAAGTGCTTTGGCTGGAAACTGAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCTGTGGTAATTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAGTAATACTGAGTCCTCTTTATGCATTTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACGAAGGCCGCTAAGGTGCTGTGGATTCCGTTTTGTAGTCGTCCTGTTTAACCTTAGCAATACGTAAC ++ +%&'''%&**798;2;36/;3/&,4/<;@?@B==2CGGFH1@:;A;?=201/02*0,,;;>@E=:AA?DDL<A>EEL6B<>>?;.)./+/43&@;CE'F>@DD@C=<;8@@4;>=<8<@@OA@AA,;DC+,:,58<?34EB;EFGIIGF?AC=>@A8>LKF?A011255998?+:<<:=557?EG@CBMK=?=::AA>?A@87A9?1<>529+1223134;;=89/+*,+/'197H695:;BB?BC9@;=:0-/+)@E=GC<9;33,$:/8<4:;:8:ACGK5?/7G?ED9(B>?@;=>A@IL9,+(+=AECA09;9=??EE8:=;;A4+++%$$+17788956:<@C;ICD=<;CABAEIAD+(=A9268---.0.*=99?<9=;A<6C9<59A=9?:A1<CAH.-6=4CH@GDB8B9:::@FC;485CFHCEFHA>9,+*2:4:%$*+,8<@BCDB>?B<GE:??DAIA:700<?<%%*EB=?D=>AEC?58;4345;6/5*$ +@SRR11410539.393872 393872/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAAATTCCACGTAGGAATGTGGCAACTTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTAGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATATGTACGTGCATGGATTGGCTTCGATGTCGAGGTGTCATGCTACTAGAAGCTGTTTGGTACCGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGCT ++ +'%##&,'2357:A-0*=BCE<9A<@B==G?@?HIC>CD:@=A>>=31:45417/48;;=>B8C3ADAA<>=<-;*9<A6:ABBJHFIE;<<:CBDAB=9+#%357=>44ACGDCBC@BI?C>75&3724?CFH23;=<88:?<=8<:<8I=@=@BCD.,-B7AF=HC5DK70::C972+678(>@?>:A<9;:=8;;=@A007=?5@:56;;:=?+728<7=8C;88@B48C@;B;;9<BB@@@ABE=>??.4B@>6011)*)*1*2/./()(%/264:C:B;;-EE=A@=812/<<<:A3B>;<:84,-9=>DEHF6;CHHFADHB7421217-C697,<2;E37CEAEAE9656==@EEGC>BFHDJED<;?,..5><0(-$$%'57E@K@DEIAKE3;;HFF@BK;314%2<AC=?9:0/8=8.7(8):@=<A=94>@?<8$+BA=;76@A@>267$$6D>>BA:*45:8;><511/%%+=57@A>>1)() +@SRR11410539.2377687 2377687/1 +CATTGTACTTCGTTCAGTTACGTATTACTAAGGTTAAACAGACGACTAAACAGAATCGGCAAACTTTCCTTGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCCCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGTGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAATTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTA ++ +''../5378;59L=?;:EF@8::80+%9476''+/:=;5364;3/,(.-'('*/2:<+,5<:$#'('##$&'/360:159D:.//78<??43EBHHCGAAA:;8?98=7JJHB>>@A(321422,,8422@ABE4:'2<C:::=7C8??JGCCA<=8JHDDEKEBEGFJGE8;@>%%.../:9))377<578-266<8;>:B217=@@@G78;13-,'(*(37;1-&&0/7;6C@>@B,&??>8911::GG5??ADA<?:<:;><='7B/-02:9979>=B<<>D37=<<14;?B1@E;;979;?<@A?>>889?DI>ACHIH@<>;CBF>>>@?@;==96;>C>A8;J6'D:5<:67;B?<A?:9A1;/0494;BDGD??@'++4;F?=4DEG>E?@E;D?%&$*)%&'3799B=>BD0>CBA::>?.@5IIHNHG:D@=;;9:;*%AA793;3.(<=A7E8-.68F?@?>>@DCNI:=;B:4*8;<<:23::863*++47><?4<99?D;-+( +@SRR11410539.379139 379139/1 +CGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACGCACAATTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAAGTGTCAACAACACAGTTTATGATCCTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTGGAGTGACATCTCTGGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACTTAATACATCTTT ++ +(&,4648:::<I><7A7=I=;C@EEBC=::7CEDFI@B?AA@=>?DDD::8+/))+5;:99;7::B@F256//:;><BCG>A;>44;59?@B8=97/C@<=;???=-538ABCCD=>ICA=9*(78>@@<7;<A@9;<>GC>++745,;52%*1'225:BA/0>@=19772BDB?==C<=>;ABA=:8>E:*/=84:467B67A?9@CB@7DAD<=CBCACB;A<>=;/49;:66#$$$#$&6A=?>?:>9@A8*-02=@CA=:32.7<;9>>@D:>448;<>F@@<?4=@=IA>???-$+,#)38C?94B:D==95><21=@:*,(5*&7@B@@@?I=@<IGA=<<;22:3;9@<?BADD<6@>A<DA@@B@AE;=;C9=8578<02?<792++=?C=..-AA;>=;B@;=@@=@CB?65;<E:LA0'+'%9<:;?=A;ACA@96=@CCCB:3/0.8@664:8A7=A851-:;@A=96?B;976))$$&641)),(%&'& +@SRR11410539.1383549 1383549/1 +GTTGTGCTTCGTTTCAATTACGTATTGCTGGAGTTAAACAGACGACTACAAACAGCACCTAAACATGGAGGAGGTGTTGCAAGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTGGATCGATGATTACATAGCTACTAATGGACCACTTAAAGTGGAGGTGTGGTTATGGTATAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCCGGCCCAAATGTTAACAAAGGTGAAGACATTCAAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACAGAAGTTCACTACCATTATCAGCTGGCTATTTTTGGTGCACATTTTCTCACATTCTTTAAAGTTTGTGTAGATACTGTTCGCACAAGTATGCAAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +#*,+-'(((046553%&%+)++2346.*,)+)<;@GHD:764453741134)$%&13;8<:=::<;035('(*9>=>@173528:4+&'7945-.0-,0+5<44;?B>,469++1&'&/*,.+%06<<:E?9B<71>A@<:B@B?9<:46/))*HJ>2=0/+'&($'#&#$#(%%%%$(),;7;<<6:9:459G@@4BE>CB::7-+919//.&&)%$0+.3/0??>26EDB@:FE)%'+,*5;21/<9*/0/3DF=E?:;/1/53'',4:;<<721:97>>53/120&.+-->?;,(&&+./4304-)%()3&''*.34222&&5$$&.,-4>:'&&&02:>=KK923'+04B6=:=F<GFEDFE@)4((()))$)&%#%%%%38=>@BC>=<?EIIK<6;<B??==GCKLF;@G?BA5G=?@?AAKI@%'?@BC@AI><;;;;9'36@;@>>99.,*..7:CCE?:00160=>>>AB9CD@A?=4<978=@E?7,1$ +@SRR11410539.914423 914423/1 +GTTATTGCTTCGTTCAGTTACGTACTTCTGGGTTAAACGGAGCGACTACAAACGGAATCGACAGCACCTCTCTTTAAGATGTTGACATTTGCCTCTGTTGAGACCTCCTCCACGGAGTCTCAAAGCCACATTGAGCATTCTCGCGAACCTGTAAAACAGGCAAACTGAGTTGGACGTGTGTTTTCTCGTTGGAAACCAGGGTTAAGGCTCGCTTACCTTTCGGTTACGGACCAAAGCCTAGATGTGTGATGATCGGCTGCAACACGGACGAAACCGTAAGCAGCCTGCAGAAAGATAGACGAGTTACTCGTGTCCTGTCAACGACAGTAGTGGTTATTAATTATGCTGCGTATGAGTGTGCACTAAGCAGCATGCAGCAGGTAATAAGCCACACAGATTTAAAGTTCGTTTGAGAACAAGATCTACAAGAAGATCGAAAGTTGGCGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAATAAC ++ +&.-$$(%57:34:*.(3<?:4093/020(',<E?:;27'*)'+--,29?CE::.3,<644/--,0;;<>%=>D?478A70.1*(&+#$%%%().89&+*%#*$-03/31%+',.3.534(201/67((/''&((&(%%%'$2+2<<B@BA>=?@EE@;=FD?B;?;8.7>@:<>89:@BCBAM>9=0344$,,+))*&(+5&*7721;.')785-5957-.'*)+%*36<,>678'>:?33=8+5&099<9-&'688>==(*3EFBH52()2-=?@9;:*=;;@>3;93382/575*+/-)4/-?1,<1448<=<F++@?@/*=1*.@79=>11401058((/312.8%()%)90/88;?>892*&-1800/('$$$%*)**+.&12%*$-,-27::45.3>?>;FC*'(+&-2%&45/9-))&(%132)&3)+*(1),+'#,./3,.**$&5(784;>BEEC69=LJC/8547<89;:(672%)$$%(/$*015<>86(*$&(# +@SRR11410539.979342 979342/1 +CAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAACTGACTACAAACAGAATCGACAGCACCTACCACCAACCTTAGAATCAAGATTGTTAGAATTCCAAGCTATAACGCAGCCTGTAAAATCATCTGGTAATTTATAATTATAATCAGCAATCTTTCCAGTTTGCCCTGGGCGATTTGTCTGACTTCATCACCTCTAATTACAAATGAATCTGCATAGACATTAGTAAAGCGAGATCATTTAATTTAGTAGGAGACACTCCATAACACTTAAAGTGGAAAATGATGCGGAATTATATAGGACAAGAATAATCAGCAACACAGTTGCTGATTCTCTTCATTCCAAGCATAAACAGATGCAAATCTGGTGGCGTTAAAAACTTCACCAAAGGGCACAAGTTTGTAATATTAGGAATCTAACAATAGATTCTGTTGGTTGGACTCTAGGTGCTGTCGATTTCAGTTGTAATCATCTGTTTAACCTTAGCAACTACGTAA ++ +*'($(-,1264<H3;:8FEE<ABGB;9@:??,=BCFG=5''1*+;<<:.855+.)/*178;672>C:B<@:>>D?<889=>68./*03/1&?DJ=F9A31ADD=A??DBDEHCEC=:37?:>?A=A?:-+&+8A8:C=;B?:A2675:@<;;:1++(CD:99>=&-'3(,HDED@;206300JFH@:=?B=:>><A?>C252G/(+(*0>:>@FDAA54<<BFEDACEA@A;97?A@63$):==7ABCK?@BC=>68>55=03,,:?4:*6997+///896-B@B7AFI>@BC00.4?@>ACB??>>3>:&'59C>AD>6>-177=EB?AIJ?>CC<C@A@87&%&*-9;7/5=;;=>,4/.>A<?:;:67??AF78?=D@FJI/3?BE?99BJG-'FC>08?@?BAF207733694.)8;<>A>>?,,1/.226=7:;::<C=>@?@/?-353<>==61/-,52',#(#$##$$&&$/258;95+)$&$)'(1()+84233%* +@SRR11410539.1420379 1420379/1 +TAGGTAGCCTTCGGTTCAGTTACATGCATTGCTAGACAGACTGACTACGAAGCAAGGTCGACCTTTATCACATAGACAACAGGTGCGCTCGGGTCTATTTTCACAAAATACTTCATAGATGTCAACTCAAAGCCATGTAACCCATAAGACAAAATACGACTCTGTCAGAAGATTTTTAAGTGTGTCCTGCTGTTTGGCCTAATCTTTTATACCGCACTACACATTCCAAGGAAGTCCTTTGTACATATGGGAGTGGTATGAGGGTGTTTAAATTGATCTCAGGCAGTGGTTTAGCACTAACTCTGGAAAAATCTGTATTATTAGGTGTATCAACATAACCTGTAGGTACAGCAACTAGGTTAAGCACCTGTGAAAAAACCTAGCTGTAAAGGTAAGTGGTACCAACAGCTTCTCTAGTAACATGACACCCACCTCGACATCGAAGCGATCCATGCACGTGCATATGTATAATAACAAGCGGGTGATAAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAAACATATATGCGTAACT ++ +%#'(&&%%&#%$$'((,(-/-)/%%$%&()%&($)&*',''(3/*%&$$('#'%&''*)((#&##&.,4(2+,><CA566-=8334;>>9&+)**/6:8-/*+,ABBE:?9<>83467=D72?*+)()678193'')*&&568,0=@CA:894<986695>:B5+8-,2)0079776234:4)5((-*)%%$&(.((&&&%%56331,*+,)1&*%%&''-42<)1823/60)78:=?CCBAC:83-)'**%(0&&+'222%$(35:=;6826=B=;>-><410-032596--)1.%+)())*.:>A>I:=897/2+.0%%)98?;C=<:<.,+=:11BAA;($?=:<<9;:12,+3*=54-/#544292,$%5.*/.65,2:>?@>DF1-;723'B7;86=;==<@<DGED(<)3++&'*.8><<&%%%%./69;863040..%%-8669=;942/*$$$%%$%)'*,00.++)((&)%+6/06CHJ>A341;@@AB7..;<>D9>9CAB9:782/)6;1224)35-/')%%(&%&$'$,'' +@SRR11410539.81436 81436/1 +TGATATGCTTCGTTCAGTTACGTATTGCCTTTAAGGTTAAACAGACGACTACAAACAAGGAATCAACAGCACCTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACCATTCCCAGTTCTTCACGACTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGGAGTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTTGTGATGGTGGCGGTTTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAATGACATAGCAACCATA ++ +%.,/(*':=?:;>'<7;==58767582$%$(<;<)CIFIL7CCEE=?>@>41;:01$%(,,48:&+46:<:>BBH>AC=>=50G;EGEFBD?B;74*).78<>?125<BB>?>D69=C>GIILBCEC4@989%&&$&57;>=118D%*?HF>++,+-'/+08=414GJB=9BCCBBC>A;34445;(*1)+5;A==;=CK@922(,')07@=>HFE6>M8@?B?ED&::IB5A>:=>HD=?==@IDA>4417A=>A@:GIGBA>EGIHC3B>@>>@::&/.//288>>>;444?>FKJJ?87<00+(219<:@<B>@@=9;;;;=46CGE=/7';?@BFCC7GEEGBE?68=8-/;;@?E=B;7524435=>?78/3.<=;<?:0&$%%'2;BDABAADE=>=?>98-6C>CI=9?B<C>C@>9GHFIF@;>A?<-31/..99<;AA<-/$*71/99;34=+*)$(/;?677>9E?:;8769568;><EFLB@>=<>?<@8;897'($%&)&&++.&'(-%$$ +@SRR11410539.1886476 1886476/1 +GATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCCTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAGAGTGAACTCGTAATCAGGCTGGCTGATCCTTCGTGGACATCTTCGTATTGCTGGACGCACCATCTAAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGGCTTCGCGGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATGCAGTCGCTACAGGATTGGCAACTATAAACACAGACCATTCCAGTATTGGCGGTGACAATATTGCTTTGCTTGTACAGTAAGAAGTGACAACCAGATGTTTCATCTCGTTGACTTTCAGGCAGATCCCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +&####%+1(36F><7>A?7<92.//$11/0-<MIDGA==?6:=99+322113(+)*&20/+))5;;75<-*:3=7?=<=//.+'(,,'.+)39//@66440,+51<BCC@?@@9?784,3344*1=?<EAEJDDA>>62)/*+4:>CCE=>@C@9535.%&&000.%4ECEC:1.&1464$*,4?7:<F@C93EDF@3@ACHHED5<;>@C?000&#*-8;95:.)*2A?@8;=68;4?6:>78,?D;>GD@@;GJ=(=AG=CB>><<:7<??<,),%)/,??67HIHC@;279>BA>;<@,.+)8?6;:;.6>6F200/,+062.,)/0&4:9>C;)#*/3,&%.+*786680))*72>?;:822<<8934$30077;98?F5,493..$$##$#&,((',,43>A923355//3692(+'+++%($/>?D>:5'>89=87CD7:+&&($%%*;19:;+.)$%#'$#%#%#/15=>>LG36:ADE<979458<;68CE5313436<67??:?A=;3.& +@SRR11410539.1136118 1136118/1 +GTTGTACTTCGTTCAGTTACACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAATCGACAGCACCTCAGCCCCTATTAAACAGCCTGCGTGTTTGAAAAACATTAGAACCTGTAGAATAAACACGCCAAGTAGGGTAAGTTGATCTGCATGAATAGCAACAGGGACTTCTGTGCAGTTAACACCCTGATAAAGAACAGCAACCTGGTTAGAAGTATTTGTTCCTGGTGTTATAACACTGACACCACCAAAAAGAACATGGTGTAGAATGTCAAGAATCTCAAGTGTCTGTGGATCTGGACAGCATCAGTAGTGTCAGCAATGTCTCTGCCAAATTGTTGAAGGGGCAGAAACTTTTGTTAGACTCAGTAAGCACCTGTGCCTGTTAAACCATTGAAGTTGAAATTGACACATTTGTTTTTAACCAAATTAGTAGACTTTTAGGTCCACAAACAGTTGCTGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGACCTGT ++ +')-343:;;>=E71)0:>?)=67>?@E/.2))73CBGIA4''-*9887/356$*$&%),.<B4A2;@AA=.)BH@C)C>79IKIADEECFB->JDDG@ADE;=*91&,9:8;5:99;4719333(';<@A?+,*05/)---.6.3A>:<64=:CHHLHEGF670<.44+%&)8:>C3,(,-3=ADEGCD0?><GLA.=?1>.6::??;04E8G/720@;>@DB@<+,1,.6=54--%'.7:5=1/;=@6?ALIA+&*DB<>@//63*'#&(*+4<+-6;=:;@A001CA5;===?@514$,2$#&5;975,13:6=404+/7=<?A>@>A5211+-FHJ?D5</7/7348;4@D*$79KI>AD<=<98/(++$%&$&&+7&:3;;ECIGHK<;>;FDC>?:9?=6HPIFHEA;A67:K@;;AAAABED8:=<6+%4050CNKE752<113(*=@A<@BIKEGI@B8D?:CAB>9;66ID=?:CBFA84=;?9:=A@?<1),,.5)% +@SRR11410539.2428356 2428356/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAACAGACGACTACCGGCAAATCGACAGCACCTTAAGGATCGGTGCCAAGCTCGTCGCCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCGCAGCTCCTTTATTACCGTTCTTACGAAGAACCTTGCGGTAAGCCACTGAATTTCGCCCACATGAGGACAAGGACGCAAGTGTCTCACCACTACGACCGTACTGGTCACCTTCGAGTTCTGCTACCAGCTCAACCATAACATGACCATGAGGTTAGTTCGAGGCATCCGAACGTTTGATGAACACATAGGGCTGTTCAAGTTGAGGGCAAAACGCCTTTTTCAACTTCTACTAAGCCACAAGTGCCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCCACGGGGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAACAGAGGTGCTGTCGATTCCGTTTGTAGTCATCTGTTTAACCTTAGCAATCTATCTGGC ++ 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+TATTGTACTTCGTTCAGTTACGTACTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGGCTCTGTTGGTGGGAATGTTTTGTATGCGTCAATATGCTTATTCAGCAAAATGACTTGATCTTTGAAATTTGGATCTTTGTCATCCAATTTGATAGCACCTGTGTAGGTCAACCACGTTCCCGAAGGTGTGACTTCCATGCCAATGCGCGACATTCAAAGAAGAACGCTGAAGCGCTGGGGGCAAATTGTGCAATTTGCGGCCAATGTTTATGTCAGTTCCTTGTCTGATTAGTTCTGGTCCCCAAAATTTCCTTGGGTTTGTTCTGGACCACGTCTGCCGAAAGCTTGTGTTACGTATGCTTTAGTGGCAGTACGTTTTTGCCGAGCTTCTTAGAAGCCTCAGCGAATTTCTTAGTGACAGTTTGGCCTTGTTGTTGTTGGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACAATACGTAAC ++ +%$46,83=@A9:<**%).59<62$2.))CGIDG5=<=B9=A>@92<=25<>CB;<;D>F;EH??GD>?B?CC;;FG@BD5655<44DDOHDABA96'$:79BGB;8IGAG;6I->EEHLA@@%%5>>?AD?.))))%+*-08;?IHNC?BA((A67552=>2&557::C@D==;A2,<459:(=;JG?C/6,+31?<DFG=I@=@?>>@??>=5/9=@CCA=08)*'.3,*:585<9;/:=,<;8/06BC<8813;3?78681:L@H:@A?FD@B@@31/&5'/-27=?@EA89;>:A914A):-3579@<5=<:29>I;>BA;@EHHKCD@E=?AEEB9E;:@A??:54--/<<<5>;8<3)&0*:3.@C:95D:;3,19?D=MDDB@=>64.47>DBCDI@IG:;<;0&'*$$,:;C?774>AC??==?BL,<ABFI6KO7JJ;AA=>6/4==@>;7621-7<'(5?AG84???B84@9A?=4DG<=99'(%::44?@?41$ +@SRR11410539.206915 206915/1 +GTATCGTTTGTGCTTCATTCAGTTACGTATTGCTAAGGTTCGATCAGACAGACTACAAACAGATCGACAGCACCTACACTATGCGAGTGAAGGGTAGTAGAGAGCTAGATAATAGCAAAATGACTCTTACCGGTACAAGGTGGTCCCTGGAGTGTGAATACTTTTGCATACCAACCTTTTGATAATTTGCAACATTATAGAAAACTCATCTGAGATATTAGTGTTGGGTATAAGCCAGTAATTCAACATAGTGCTCTTGTGGCACTAGTGTAGGTGCATAATGGCATTACTGTATGTGATGTCAGCACAAAATAATCACCAACATTTAATTTGTAAGTTGTTGACCTCGATAAACAACAACATCACCATAGTCTCCTTTTTCAAGGGTGTACTCTCCTATTTGTACTTTACTGTTTTTAGTTTTGATAACCAGTAAAGACATAATTTCGGTAAGTGGTGGTCTAGGTAGGTACTGTCGATTCCGTTTGTAGTCGTCGATTATTATAATAATCTA ++ ++$$%#&%&004-//-'#',)&.,-+/)0,18+06&'-&'+%#$$$$'(&%&#+.)),--)(+)7:<;0>-??=757;7'26---&$$#$$'-34.2-/&$&$.&3*((-)&&%0&2?@>B>BBC?;44000&.,&,%&%&0&)3:=33+,&+;.2-,)&&+./698@65785+,:;778.0+801251%'$$*'())4++;;:B<>?0)C+..4<@;@6+-+(),'(+36;671<7;22+.+3+--3*1+(*##%&&.(15:>B@::5@4-+)&-(.$6;=A17A@BAC;>?3467;;:3329749:;DEA:6<?<B77788683?=:;:?C21&'+'*',-*#%'6()$)%'%)&&8*(''*7,,-..-+'3$/.//24.989&/8<?53:<79,/09@@B1/.7AAA=:>;<;CA15'-/''99;;;<<87=<>+,<:45;>;>,1'(/&&)-('=+../(,27.4&(&%(/2304**+)+*%60&%&/0-$*')$,(($'(*&&%)*'')# +@SRR11410539.278949 278949/1 +CCATTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGGCCTACAAACAGATCGACGGCACCTTACTACCGAAGTTGTAGGAGACGTTTATACTTAAACCAACCAAATAATAGTTTAAAAATTACAGAAGAGGTTACATGCACAGATCTGTGGCTGCTTGTGAACAATTCTGAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGGTTTGGCTGTGTTAATAGTGTCCTTGGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAATTACAACTACTAACATAGTTACACGGTGTTTTAAACCGTGTTTGTACTAATTATATCTTATTTCTTTACTTTATTGCTACAATTAATGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTAGGTGCTGTCGATTCCCGTTTATAGTCGTCTGTTTAACCTTGTAATACGTAACTTT ++ +1'$$&$+&$$&$-(,+$7=5,1&725<:9B56,210&(07161>243)7//@@:<222'1?44))(&''''(,,*0-/$$.%,,(1(2/325%&'%'$'%%)+.*24%%%;>AD<-9,75:516654138557797(.-=6.$&'&%$%0*+2-5+'6>@;B@<A6,*((.85740;1+*,;<FC8:B?9>8:/=65502)*1884=<7.9&8',)>:==4456:203379AA661089@B?71/-/3+7?+100)07>A?A;@6E9..8.1'(12;42..*(*%$,$&%(///5:78%252AFBACA>?=EEE@<?<BA()')46793;;6@;<<:723283//.)296658578*224?=8:B.123/9;87,('%&%$213?7961../11)()+124356,3$$'#./2599600.''/0-:;<99.)87.6)9<=?AC43;?;?<8,'$%1;6>8<A:,%7766($,=??=>6/)(/63;>603+)02238498+%''%%))85.1146-,))%&$'**,-574--$$+* +@SRR11410539.666616 666616/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTACCGAAGTTGTAGGAGACATTATACCAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTAAACCGTGTTTGTACTAATTATATGTATTTTGCTTTGCTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +'&%%,20-/7.&:694@E<2D@IOJK><>$%2GIHHJ7)%)%86550--783=-1/399CJ=>62'BBFHHEAAE@>=A@E:214'/9BD@@B4-%$$565/;B<EIJKGCG61BII@EH,*98?ABB>;<467C:<::99B=H?B?709279===7=;1149;BIKGE<>A;1@311;=E>64/))+-*&'9@6ECDGMKE?AE=?5<.0:FFIIBB@DE7//A=13199<CKAD=:B=@B<58BAC3)-8>@@A3<-GA9:?99?=A=>9;73-11;@:4546?=74;687>=<GNG;@<**7<==;CF5CAG:IIC::>DGD:?AFC?>?<@>5=C6<;ABA;=9:<@B?9;F5B@=)BE?A632,'64434-%%'(.+1=?IDGF1/=E7ABAE?1?A<@ONVLF;9J4K@EIF??@:7:75:00405GI11.B>B=A;==;44*1?=DE5-<;EE&-9<44<?AA>?0?@==93A==EA:<=LHKCAG><@86B:?<=:)*))+028::::;<+,$) +@SRR11410539.175445 175445/1 +CGGTAGCCTTTGATTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTTAAGAACAACTTCAGAATCACCATTAGCAACAGCCTGCTCATAAGCTTCTTGAGCAGTAGCAAAAGCTGCATATGATGGAAGGGAACTAAACTCTGAGGCTATAGCTTGTAAGGTTGCCCTGTTGTCAGCATTTCTTCACAAAGCTTGTTTATGTCTACAGCACCCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTTCAAAGGCTTCCGGTAGTATCTTTAGCTAAAGAGAATGTCATTGTGTAACTGGACACATTGAGCCACAATTTAGATGATGATTCTACTCTAGCCTTGAGTTGTTGCAAAACTGAGAGTAAGACTACTGATGTGCAGGTGCTGTCGGTCCGTTTGTAGTCGTCTGTTTAACCTTAACTTAATACATGGC ++ +.%&)&&$$#&(&&-/84-6;<8233100/,,()*:KGFI?>>?A>?=>CGEDFA9:==902(%&215:?>?/2DEAECB6@GCC;=BGHBF=:?=C<633336@<?;,+*(*2?BCBBHD@BDKDBAA34EMKF99=><BAB@A>BBBB@AEFCC@G6C4BAHDCKE5534.'')%#()):<36=9>;DC:3%%+))-11897<./52(743>?@DF>@<7:=:<D@JJGNEELI21'':;DEAHKPL>CC6-@DA>?ILHAMI90:DECICED:EA@?B;;<C><=9=?GI?=3ABC=@/964@HKOB;22E@BB5C/?EEEECDBDFNH+>@A09<DJF&)%/>F=CD?@H@6,<96CF,&'25@<?=B@CE@DBABB?D>BCB<GF?>&&763%(1716GFAG?3287:>ADB@<;=+)%#$'(22=FG?CD<CHHA>849-2-01>@C@437:>DBF@FE,:(4?:;;939&'(&*%&).(-'14;76=;<:63'''1,.$$$%(1320/%$#$% +@SRR11410539.767457 767457/1 +GTTGTACTTCGTTCGGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCACATCAGTAGTCTTACTCTCAGTTTGCAACAACTCAAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCCCCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTCACTACTTTCTGTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAACTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTGAAGCTATAGCCTCAGAGTTTAGTTCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAAGAAGCTTAGCAAGGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAGTTGAGAGAAGTCTTTGAATGTGGCTAAATCTGATTTGACCGTGATGCAGCCATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTGCAACATTACGTAACT ++ +$$%%%&''*)4?*9%+)-)A?HKGC0/.6(>GD>C>81/59@B<777CEB;.4.;<;<;?>?CFBF@E?A7B72@?>=D3+)(+**9A2;6;:>J?@66EABB>?%&)1716@<A.'0.3=643--4=<6:GFGD?A<2>>,,7.?/8BAFFDE@AB?@<7927+01<8$$$/>?)&=@@ABB?AABJI:>A@7?/9>?@D?>A5+($#'(&)**/:;A@40/019)-;;:72B=BBBD@?A77@AB><<2/+,%245;3)354&44A>?<C14EDII7A56;;1/('&(%%$+56=52<98+A@@7FCC6/7?;58:;<>8:=>?@229.9:;;E@?CEC::188399'&(&'&&%'#&-.*.,+.>==7,-/59<=>46>88J@?@BB>CEFBJE?EA=?<<A<?60=<=<<8?GG=:;DBA=5851441''&*)&)5:9>A?FGEI7E;EFB;/4'$/>?=D:9DAAEF:=<HGKB>GF=A84@:7=3)-,,,.-3783&''&& +@SRR11410539.465845 465845/1 +CAAGCACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAAGTCGACAGCACCTCACAACTTGCGTGTGGAGGTTAATGTTGTCTACTGTTGTAAACACCTTAATAGTCCTCACTTCTCTCAAAGAAAGAAGTGTCTTAAGATTGTCAAAGGTGATAACTTCACCATCTAGGTGGAATGTGGTAGGATTACTAGTGTAATATACACTTTTATCCTCTCTTAAGAAATTCTATACCTAGTTGTGTAGATTGTCCAGAATAGGACCAATCTTTATAGGAACCAGCAAGTGAGATGGTTTCAATAAAATGTTCTTCAGGTGTTTTAGAAGAAGAAGTAAGATAACCATTATACGCTGTAACAGCATCAGGTGAAGAAACAGAAACTGTAGCTGGCACTTTGAGAGATCTCATATACCGAGCAGCTTCTTCCAAATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAACCATGC ++ +,&'%%&..768H/1,:;?>C?CBCB:>9&'2B@<24/,%&&'5745.,01$.()(488D?A;F5@=,/:D01((,041;32::5.F@@482(66446:><CB@@>DDGABAAB@?<>??<9:;E=E>CACC56:II3*@<;%*)=@F@B;;?@475;-)9GG8(<@B<B:*(=D@C?>61B6BA=:FG?@68@05>@;=;FHBD<?C?>=762/++/9459;::22<'/@FI?78048<<2B0=:8=9B=DEF>@@;@=@?FB//@A?>H?ACFGBD8712796B>A>E><;=H<;9:9AGC=A+<?DFGD?A?;D;6//:<;<>=?;EBFD?NCF9?;/+)40778>@FD=9>89>DBB=?BEBF=GDB1,64.+%&)14>?H?BA6;87AF3.8<FIJCC<<?:<==>A6+0)*182?4<B?@IFEB.2:.*;CAGA'*'*3?C;<;<>:;@<ADGMICE>JFD7*&6=?:5>=:873*+&'$%+&+'(+-&%$# 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+%$"#$$%$79<7:GD%(%+9;6@>CHAA779%&4@9?CE92((-6<>@D88=@4:24575-%&*****+**%'14:B;::9&)+88=??:>@B?BGF@CHG?<9BE'B?98>=9;?:=IKKD($8;</A430''--/;?B6<EB?FCDG7>:=<AE?>EDAB9/43070&)69367==:@6F4F;=B;6C::DCC../;:4(''''-11DA=<NF;5;1?;=AD419?A@A@?===?;:,.-**)%&(22,'%+&$&6.6C9;>GA9:IF?I;@>E910*1.-048A=@;>EHBA=HIE=A668D@=78/A9912955>ABBG@99MHGC=?>68<;@@<3=AGC@<911.(2:;;AA@>;65?BBBAA?DCE<CBC;=?=:<:>955-**,EJFBBC6600256<:;;A@B<852&&'$(%*,,,+*&))*)-.012:DBPD<?;8::C8<,;CCBI@::=BDE=>9?@@/1977,89=:@ABA?CD:;:<;88:;8-,' +@SRR11410539.2368368 2368368/1 +CGGTGTGCTGAGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGGCTAGCACCTTCAATAGCCGCCATAGAGGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAGCATGCTTAGAATTATGGCTTACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCCGCACCGTTTCTATAGGTCGCTAATGAGTGTGCTCAGTATTTGGTAAAGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACAAGGTGGAACCCTCATCAGGAATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCGTGTTAATGCACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGCTCTTT ++ ++#&($'*')*&''(/-2?A;74>:;>54A;<+AEEJLI?:9AAEG?B<:9:5<,1,,,/#$$%$##$#$%(%./..042146,*/)(>;,+,78A?C?<58?;>:>@CIG>=>1401<:<<?>B>BB7:9<99:8967286:BA<=DMD>A?KKJ?98AIIFFC492>:E651*$&),0'*147<3./0<G@26B?EFB3352ADF<==33,<*CFDDC22B<67*&%'(,,+:*83373;%-,&&.1;>@EE;NK:4:A=CAC@BA=>;12+(79BFD<G:CEE<++1'56528<<<@>?*0&%c?84501:C74-,6*)(60114&)/%&$&368;29=A;=?9D;<=B6;KI;>@<9>A--2-%&&'%&)$%%(',03,,0*0213-&.**,,5=<<@C>9?DB<<B9:7.+59<=>EC:>@CEGDA634)*+22$+)&&%&+,*14,/:;AB@64271983+2+8=>>>D465;;DAAA@5:5-+*,++(++,,,/976773).%#)(((* +@SRR11410539.1722559 1722559/1 +GGAAGTGCTGCTTCGTTCAGTTACGCTGTTGCTGGTTAAACAGACGACTACAAACAGATCATTTCAGCACCTTTCTGAGTACTGTAGGCACGGCGCTTGTGAAAGATCAAGAAGCTGGTGTTTGTAACATCTAGTGGTAGATGGGTACTTAACAATGATTGACTGAAAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAGTTTACTTACTTTAATATGTTTACACCACTAATTCAACCTATTTGGTGCTTTGGACATATCAGCATCATATAGTAGCTGGTGGTATTGTAGCTATATTAGTAACATGCGTACTACTATTTTATGAGGTTAGAAGAGCACTTTGGATACAGTCATGTAGTTGGCATTTGCTCACGCTACTATTCTTAACCTGTCATTCACTGTACTCTGTTTAACACCATAGTTTGCTCATTCTTACCTGGTGTTTATTCTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$%$$%#&'-***,9:HA>67@<35$$)$.1$#$$'$+48.<88<?=8/.))7:57&&0,8%%%$%3+35;<AC6>4238?7<@8A==60(.+,/)*2315;9=-51'B%%*::;=<:;=>?:*''$$&')'+%-B=@?8;:.9<=<822355;?@8''63&%%)%$&',:<=KHB<=AC?60CACNEDC?:9<98;8<98315%%$%''*'$&''$$%&&%*7;9;CC8/)245CE6GHGE?23@>:2:74'(-+17:G>@F<?B/).-.00.,*(%$+())((,%*5@BDIJH<@=>?5*&&)*-37<?:99,.#'%()==@EBCLHE<;)/9?864@>*3)$"#.0/()1(%<;;=@=7-)-((+'*,$#(/%#&%$)%&:49@89-/)*$$#"&69?=>?49ADDA:EEAC@GHF><>0+*($$,/:8$###..5=CBAD?I8;AEKMHFCC?>>331+<<?D@49A@BD=@=FELA?DA=?==?AB<?A22*+*+1-0?@8:=;;.3(( +@SRR11410539.1005600 1005600/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGGCGACTACAAACAAGAATCGACAGCACCTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTTAACTGCTGTGGTTATACCTACTAAAGGCTGGTGGCACTACTGGAAAGCTTTGAAAAGTGCCAACAGACGTTATATAACCACTTGCAGGTCAGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAGTGTAAAAGTGCCTTTTTACATTCTACCATCTGTCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%/313277244=>71>@B?DAEDEB<<+3*3BEBCD62-6*=>@:1)-/0'0##(,88517)1(,.120<>11DABBDA??*((&&/48=@>@23<15>;;:HFDB;@@8:F@<8767+6<3/-><9DF=EB@>-765<B>>E>CDJHIL4B>F12490*<C<<<=,045<>15B@?<?&(+1598@8CBIPE&FB@>@GABB==7314'))-$8=>>1/0?@<9A@EA668..5'%-1<;9<77'1'%',%-$6+'-'*204/7;DB>@<=89556:45/%((4698A@<9>5212('''>>/374==?=45AA99CAEB;4;5<><439941+0$78:>A66;:0&2ABC@@09;IHDCGBACG3*5'/20.,68<<IHL?C@A36=K@@678/<1?6@;9229-(7<?;@A9@==?ED@BCEC>EA<A@:-7;56.46?DGC::6?=:9;BAMGBC:BAKA@FA;8.4;798><88=714:AC>>:GB@>0-#' +@SRR11410539.1784654 1784654/1 +GATGGTATTATTTCTTCAGTTACGTATTGCTAAGGTTAAACAGACAGGCTACAAACAGATCCGACCAGCACCTACAGGTATTCTTTGCTATAGTAGTCCGGCATAGATGCTTTAATTCAAATTGTACTTTCCTATTAAAAGTACACAATTGTAGCAATAAAAATAAAGAAATAAGACATATAATTAGTACAAACACAGTTTAAACACCAATTAACTGTGATGAAGTAGTTGTACTAACAACTTTGTTAAGAAAAGGCTTAGCATAATTAGCTATAGTATCCCAAGGGACACTATTAACAGCAGCTAAACCAGGAGTAGCAAGGGTTTTCAAGCCTGTCTCCTAGATAGTTCGTGTGGTTTCTTAATGAGTAAGACTAAATTGTCTACATAAGCAGCCATTAGATCTGTGTGGCCAACCTCTTCTGTAATTTTAAACTTTATTATTTGCTGGTTCAAGTATAATGCAACTTCGGTAGTAGGTGCTGTCGATTCAGGTGTAGTCAGTCTCATTTGGCCTCCCGTAAATATAT ++ +*%'%%'$$&$"#&$#'1-000/,'*&&+)*1()*%#&)*$.132.$$'-*&''*,+))$$$-('%,0*43523('%()*')/5573--33+%++++**145<5/-,11.())%02-.'$$$06&)&),-5$,0+%&451&$2245222-2'''),581%&/6)6@B:&4/95354+2:9:9/0.-,%+%+2443.)'&,-,9:86&$&'+).''&,#&'&/**(&--3,3%)$*212:-,)56.%*07;17;/';.((.537<9BEF;387/43.12834::./-3@<;1?@C6:647;/29++***'$'$$(#1,+%(%&*(159:52'(&//*%%%'(-+&'*&('$'$$+&''*'()%%%))--,.,')+%%,$%$%/25A<<=CA?@-.(021&&&%(/)<*+))1,+..&&#%&%(-:A=;686=?;775&&,8001*67@666(,+.*$&$,,).0.'&&&%354/33,/5755;::>50//(((&$&%#$%$%'&(',,**$%''#%%$)$+($&%&$&%&$$ +@SRR11410539.1998471 1998471/1 +CAAGTACTTCCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACATTTGAAACGGAATCGACAGCACCTACACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTGAGTCAGAGTACTCAATGGTCTTTGTTCTTTTGTATAGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTGTTACCTTCTCTGCCACTGCTTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGAATATGGTTGATACTATTTGTCTGGTTTAAGCTAAAAGACTGTGTTATGTATGCATCCGGCTGTAGTGTTACTAATCCTTATGACCAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACAGGTGCTGTCGATTCCGTTTGCTCAATCGTCTGTTTAACCTTAACAATAA ++ +0%&#'*+02)-35C<<7<=<*601127?@F?>4GIHFH8;5954'''&$--,2:>9;9??E>EAE?B:3:$-)@<DEHF=A69DC8@@?><@6603/2C@@5-LDA7:;ADB;BD?B1&#-*661&-:8<DEAAA>A7865DBF??ABPGDC?:**<>8GC=889?ALDF:>IHPM@DBEA51<?99:336:?CF?E>@=++<?JK>B>BEGHAA@AC<7:EGK:A@;;=C69=GB@AE5==;;JEKAEDL<2:>6>?C>@<630116235&&'91-24=JHHD=>BA@08<?<4088AEEC@=842683,<3+)*)04>;???@?=;6C6;G.7*----48C@D@,)73/(,8<;C@>?NLA459?=IQD.0>;;5$<78<7EGA6/(1+15'--,*$&#')/3687>@//4,-6:@8&*'+,&'=928:87+18A64AAAC>B=BA@;C0905D><*34..).;DC??@<>C>A=?B>FD5,$%%*+('$.356E=50-(*),&&2++%#$ +@SRR11410539.2476742 2476742/1 +CGGTATACTTCGTTCGAGATTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATGACTTCACGGAAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGTGCTTTTTATTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +%#%'(%%,-10;>/+$442192E@ACBBD9:3JMHIJ::&&3,8+40')356=2638?@BC61BFH@@BN@@DD@?BD=ICBQH;;DIIF<==B@<H<@D==8?24>*ACA433%&&$-2:;H=)<59;:?'+5BBEHJDD?>9@@=?5%68EF@E@@6<?D>?;:.1=4/>6771+$//12/5/'(,%28D9.1678<=DDN<>@CIF:C7B=;@DC=815?<B=%+$%&%&''+5434GC??A<A962655B=@@45;**79@>>?=>:NK;<@63B>=:4>=;39>?<89238I@:;;9-)(%*<;CA378;<B5;?A?A7=:<>E79>BE>B?:;70/+/+1;@=?96A7GIDH@D54=933</D?ABEILGBI=AC964DE117>?B?D/&2'*9;67+2D9:?89;;.0;443;+--4-,8678;8/%&(,6:>;8:@ACC8=CB3);+563:>?A@971/%+,%.3;;6-/,85842521=>978;846/7734438661-% +@SRR11410539.548657 548657/1 +GATGTACTTCGTTCAGTTACGTATTGCTAGGATTAGTAAGATGACGACTACATGACAGATCTGACACTTTGTGTCACACTCCTGTGCATCTATCATACACAGTTCTTGCTGTCATAAGGATTAAGTAACACTACAGCTGATGCATACATAACAGATCTTTTAAGCTTTAAAAACCAGACAAACTAGTATCAACCATATCCTTCATGTCATAATACGCATCACACCCAACTAGCAGGCATATAGACCATATTAAAAATAAGCTACAGTAATAGCGAGAGAGTAAACAAAAACAAACAAAAATACATGTATGTTTGACAAACATCATTGCAAAAAGCAGACATAGCAATAATACCATATAAAAGAGTAAAAGGCATTTTCATACAAAAAAGACAAAGACCATTTGAGTACTCTGGACTAAAACTAAAAGTGAAGTCAAAATTGTGAGTAACAGCCAGTGGTGTGTAGGTGCTGTCAGTTCGTTTGTATGTGATCGTCTGTTTAACTGCTCTGTATCCCGTAAC ++ +&$'#'%&&+%150782?==96750/&&(&&-$'%'#'#$$%%%'12776&)(&&&&&%,%$####$$%&%#$$%(15:8)*.0#$#&'%%''%&(,//89:9<@<=<,.50,:,9'))3)=9%&%,583C?B<:C>D<CB?472002,*'%#$%-00(--*'(%$$$%,.3459:CADECF?;93361+<))+,27?**/()+('&,0//&(##%%.-(/)%))335650,+)))/47>:322722602//./,'&())'))&&&&+#$#%%&%'%)%($(-/+.341.*/130-'(%&$$.552)386<EGB>DFGHD;?;7237,.==56613--0/4+0),7821-&&,.($%$(**$'&(.78-(.;=BCFLHFC=A<BC<5,+%7801/39-/3..00*;=<B+6=67661EHB:4456+&+-0+1266::5**./53364..&(&%%,-;,-9/>;*((20..3,%-$'.,-+243'$''%%%#160.A19=;6)&$0#$*'&$#%&&(+'**+% +@SRR11410539.2286820 2286820/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAGGCAGACGACTACAAACGAATCGACAGCACCTACACTATGCGAGCAGAAGGGTAGTAGAGAGCTAGGCCAATAGCAAAATGACTCTTACCAGTACCAGGTGATGTTCCTGGAGTGTAGAATACTTTTGCATACCAACCTTTGATAATTTACTAACATTACTAAAACTCATCGAGATATTGAGTGTTGGGTATAAATGATAATTCTATAGTGCTCTTGCATGGCACTAGTGTGGAAGTTACTTAATGGCATTACTGTATGTGATGTCAGCACAAAATAATCACCAACATTTAATTTGTAGTTGTTGTACCTCGGTAAACAACAACATCACCATAGTCACCTTTTTCAGGTGTACTCTCCCTATTTGTACTTTACTGTTTTTAGTTACACGATAACCAGTAAAGACATAATTTACTGATTAAGTGGTGGTCTAGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTTAACAGCAACTCTGTCTTT ++ ++35)6/<?A<>K950<9=EC@EGDE<:A//3D>18'%4.20.979507;=7+3$:::=?:B4AAA?9,'':?B<<4678@=8C::3@9B:>;96.25:>C=A@?AB96-/DEFG<>:?A<?>:;3%$$(,,.44,%#)#)+),+$%$,-*03122++146;9@B322@?<;92,26><@<?@A.('&$%)##$%%'$(75:>@:;(57:BEEFIABBBB=;8;><==66(+124+.+,$)(83:GDCI=GC./)%0*.3'+*'5/3%($$%$$(%'*==<.5DCDCB@@20;77@@>=402$)++158>FC?B>E@B?CA>+8IA889<B3,3-/8=>@>C>597>.0100./$$)&&03.,%%%(9;:<541178QL2+2&0@@>;D?8=5530@A>A1-*.3=C?;<>>;:80$%261&+6;>A=?E>-1=?A<8D=?>4545(##&+%23*-5:9:>97562(-/20241/.)&&11-/0/69>>@32335/877)$.,*,*+'$%,+&)*0,32/2( +@SRR11410539.1849204 1849204/1 +CGGTGTACTTCGTTCGTTACGTAGTACTAGGTTAAACAGACGACTAAACAAATCGACAACACCTCTTCTGGCCCCGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCCTTATACAATGCTAGTTAAACGAGTTGTTGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCACAGTTTAGCTGTTTTTGTGATGATATCATTAAAGCAGATGGTACGCTCATCGATTGAACGGTTCGTGTCTTTAGCTATGAGCAGCGCACATAACATCCTAAATGGGGTATGCTGATGTCTTTCATTGTGCCACAATGCGGCAAGAAAGCTACATGATGAGTTAACAGGACATATTGAACATGTATTCATTATGCTTATAATGATAACACTTCAAGGTATTGGGAACCTGAACTTTATGGAGGCTAGGTGCTGTCGATTCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTA ++ +.%('&&$()*&/00-+.0/($%%$$$$)-'5@?;=61%%)$319(,-$.,/43,-%/(),--.*$$$#$#$)+,-<?=:78+7811;1223/&,/>@,2<@9;<7*)32/010423023'*##$'#%13531*$)66672-&%*$'&$')+27=-.68569:79.3.2255.2+&$&(39867%))//+&'#(&*)(/12423433()%(42,-*)0'&++-(%.)0*..0.,1'(+)#$$***6899;2-6+0446/389410?97-&%#&&$($&%.&%++,$$#%)--)%$&(212.*$%)#%$../1-1125'3263-123$$)#%%$%&+)%686168=?A=89<JG?>3.<93'#''&($$&'*,.84/3*'+/11.,--'../335A==%%2222,-(5-,/2())(+()'*$**--*78'+'67:5.7+C?>C*$/1),-23=>E9;785:548728;9'(..-*&$$5.&&/,&& +@SRR11410539.2113941 2113941/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAACGGAATCGACAGCACCTGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAAATAGGACCTGAGTTTACCATTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAAGTCCATGGTAATGCACATGTAGCCAGATTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAAAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATACTATAATTGGTGATGAACACGAAGATTAATGCGGCATGAAAGGTTCAACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +$%,.+0/;=@<=EE@88AA:*$##"'66;./2GJC>>,.,--.$$-3/74:>504>>;A:A84>BBCCJ<;=;AEH8/%'((/-7@BCBBD?E@=.??BAB?<BOL>CDDD/9<+/(5:42-)'&#$#$$%'58A=?@D<>CDA0+5+0+>6=;98A<<899HF>A@AF;:=?624D==<CE@?DDAE88<9:BA>B<:;:.&&+.3.9=AB<><586'2@DDCF<>@;A>BCCC;@?@AIDIIE;;>?@G67:>EFD;115218/177=B>IJB=?*+><@9777?<;>CFE<2<&(%%'(-5:/0;;>?@?@<=;;94+*')(048C;:@@F;==<7>68:64.&&9B@:<-5/894224*)'/,,)@866:GCGD<CF@2.9<<--.<:=:=AAEC:98,'###&*)))(-<>EAA@A<93:721:3--2%-//999533/.1'5C@?D--.:*5'79:?=@BEF?&',$&<-155=?3+<<<DFAAE>??A@322134431&&% +@SRR11410539.1457535 1457535/1 +CAGTATGCTTCGTTCAGTTTCATGTATTGCTAGTTAAACAGACGACACAACAGATCGACAGCACCTTGATTTGGTGTCAATGCAGATGCAGTATAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTTTGCTAACTAAGGAATTTTATAAGACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTAATCCTACTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCAACATAAGAACAAATCAGCTCAATGCTCTAAATGTTTTTATAAGGGTGTTATCACATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGAAGAGGAAATTCCTTACACGTAACCCGGAGAAAAACGTTGGCTATCGATTCCGTTTGTAGTCGTCATTTAACGCCAGCAATACGTA ++ +%$%$%$##%((391,%($&%%#$$$'%'%$$%&%(+--4246-.*+&)(()%%9<?>9:78@9==ACEBFG=*/574@893018--,((&(+*+*+,..,2589,;-+B68:/05:674256>9;2413088:6:.:;;@@B;4---*(%(2++00''%)%$$$$$#%#$$+)575206;>=E,:<96-)-(,,''010/0631+,/2//2886:?%%7-.1-(%'6:.2-)2568<>>:5>49:,+/00$$*,,245356@D=?>A>622/'+--2>600199=IG><==><35)())%%&)))&'$('#+-70726?<=//**(*&'&./)%$$##8<A23/01?;BC<3>5=7899:;<;:=:89;(4:;5:0/.0-/9::8@?;?22:<:4+-*+(++*$%$&**1*+*'&-41/-,%%(,,+530($%%$%%$#%$%5;:EC6;<C<9*+&&3<97($0238/6('',)-<@==:0'& +@SRR11410539.1039522 1039522/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTCTTAGCTAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTGCTGTACAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATAGCAATACATCTA ++ +&%%%2:8=A=7;N=D?BIHB;64)38=AC>;7DMIHLD7989:=<?;=:==-4.,>;?=C96;88ADBC?9&,0*>88:<;89136;?504*;-/LG7=/+'((;<59*#('652'@:=@=0D<A?9>?@D4=>?;99A@B<?D<''>@DDEB;;C>B=>?BAF6(&,+86998;3::'E>9960<954+2/12=EBBBSOE?8<=EGLAC=@A9;<DA:9@@G&&-))(.&'D=AB@?.&66;8=>EHE8*/9-77A?BDC7DCEC<==FAC@7@?494;BD00>=>>C><=0557ABF??4;F88GCF=155;9;@;99;A<<A9?@:IHIA??A>@?;=??B6<993?>=ACDB0*(..//@BB;GF8>@EFB@BCIIKFF?@?@B@DDFGCKFHMB.,5A>88H6>7@<>EDBEBKCFEHGC>DE94C:A6.===><:<?CC?HE84<:5,..-28><<:<8CAACD?A<A>CCBC?9;:=>:/454%%.',,**9<9<8'%%(% +@SRR11410539.1855281 1855281/1 +TGATGTACTTCGTTCAGTTACGTATTGCCTGGAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCCAGAATGTCACCTAAATCAACATCTGGTGATGTATGATTCTTAAAATATTTATCTAACTCCTCCTTGAATGAGTCTAATTCCAGGTTGCAAAGGATCATAAACTGTGTTGTTGACAATTCCTATTACAACATCACAGTTACCGAACCTAAATGTGTTGTCTGTAAGTAATGATTTGTGGTTCATAAGAAATTCACTGTGTTTACAAACCAGTGTGTGCCATTTGAAACAAAGACACCTTCACGAGGAAAGTGTGCTTTTCCATCATGACAAATGGCAGGAGCAGTTGTGAAGTTCTTTTCTTGTGTGCAGGGACATAAGTCACATGCAGAAGACTACACCGTGAGGTGCTGACTGAGGGAAGGACATAAGATGATAGCCCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCTTGTAATACGTAAC ++ +#%$(*././/58<=,)-)+026:<<=::;=48$)<AAD<8014896>:+834--%(&)389E=@=C:>>=<6'442/1.)69:?.?6B85@45CB<BC:=CCB?%9<;<8:48.3@BE?::;=72/<4*2/0*02*.+1=:=1-059=AAE?@$(:3C?@7(?@)@>A9<A@BDB;;8;8;>28<A@>4916/047278=78@@;B8@@DC6.*4%%'))'9;@61.*EE??A@<<)*>;CF6>4443.(',@?>=767&0104.*))/196;=:E@HIB4C@BB8&7B>BBCCC:@5C>;BC55=8A6;A?:952/3/(,3*9531056;<6<B<@C@?C<@A85%(@B?D:<1-CEH?A::=DEE?MHOD>KG?(<3=7;555=?::346=A4=340*(%/165=?A=<74/0,*,=>><<=4,*+$)&'340>:<+,?B@@<88;7>@>986><43<<9=:8KD8?;AFE43--75/1>6?>>02'*+()%%-.26500*($ +@SRR11410539.2360387 2360387/1 +CAGTATGCTTCGTTCAGTTACACGTATTGCTAAGGTTAAACGAACGACTAAACAGATCGACAGCACCTAGCACATCACTACGCAACTTTAGATACATTTCTTTATTTAACAAAAAAGGTGCGCACGAGAAAGCGCAGCTTTCTTCAAAAGTATAAGGAAACACCATTAAAGACTACACGTCTTTGAGTGAGTACTAAGAACCAAATGAGAAATGCTTTATTGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGGTACTAAAGGTGTGAACATGGCAAAAAATCCACTGAATATGTGCTAAAAAACATCATTAGTAAGATAAAATGTCAGTACAAGTAAATAGCCAGATAAACACCAGGTAGAATGAGTAAACTGGTGTTAAACGGAAGTACAGTGAATGACATAAGGAATAGTAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGAACGCTGGGAAAGCTTTATGCACCGTAAC ++ +($*((%$..2>=L@A:<>5-$'0-233710/%%-=F?771,'&.44/1%24'.*+4.4<>765=6@B32,*+463?99=98-.34;<?:@7F;CEEHID?EED?@<=97576<4.&*5/+%'(,-$$$')02>;97@<:<@8C*5EE9,''%#%&'1$(.,3369::BC.-;78??:);6+98,'$')&'%44)501&.2&'*,)/))*17<219;;1''*$''-6=@<9:<982*&-+.(;;=<B;@A@%%85/33,'22=<=?EG1,2609773952$$$((((/-//7334644;@87<::;BC?8733?>C>?>./>:;,D@AD@E::3+&%%$$$%)***)&%$$'%''%&))1%'*)/1*2'-81+-28=>78815;>BB??94#&$&%%''97<E;@AAEA77;<5>:A453<786)?87:GK44DA>3-5,45?EE?>BEDDAG?A?:9%*..29BA=BDEOD8::??F32663.*07,1$$$##&$''%'%'$$#$%#$$%#$$&#$# +@SRR11410539.1444645 1444645/1 +CAGTGTACTTCAGTTTAGTTACGTGTGCTAAGGTTAAACAGACGACTACAAATGGAATCGACAGCACCTAACCTTTCCACATACCATAGACCCGGTACAGACTGTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGTACATACTTCCCCTTTTAAAGTCACAAAATCCTTTAGAGTTGGATGATCTCTCTTGGCGGCAGCTTGGTACAGACAACACGATGCACCACCAAAGTTCTTGATCCATATTGGCTTCCGGTGTAACTGTTATTTTGACCAGTACCAGTGTGTGTACACAACATCTTAACACAATTAGTGATTGGTTGTCCCCACTAGCTGAATAATCTTTGGCGCTTTGGCAGCATCTGGCAAAGCACAGAAAGATAATACAGTTAGATTGGCGAGGCACTTCTGTTTGCATTACAGCTAGCCAGACGTACTGTGGCTTAAGCGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTAACT ++ +,&)#%*'**,&#'&((%**/$$&-$58<;A=0;AC@C==A?F<AC@@9723'&')*2719350138@9>::<>A<C<@CD840-1&')+.)42(/38999C67'1566243C<AEGGGCDHE@A==A8B559D>>)9=?>CEBEICABAGCH?8:6,%%$$%$%(23<>:?@=872..37=@78;95*$$%''*-/+-*)&3$'&(&&#$)#%&'1.///6::9:;B;::8,=,,@942;=;:0*(%($(A@>>767)93:,37845G:DBAACF??>BBG6,--((9:BCACC=@4+71-/95BCABF>:;??@CF?6-+69A@BD9:CEBDD9;>><788=8>>;:5:8((0563+1"%-*,+'(-14)0*''0+/1&%&)(*'$$$%)'.+45;>3-&$%%.*.$$)).-0.'%$$+#$%&(+&.0/'+$%&$+&'%%'&%%126+;<3:;6211%%%&'($-.>;<@=8<?445#'(198%$44:=0*B/A::<50''&))()11$$3;;74'* +@SRR11410539.2257537 2257537/1 +CAGTGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACCGGAATCGACAGCACCTAGGTCTTCCTTGCCATGTTGGTGAGCGGTGAACCAAGACGCAGTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTGATCGCCCCACTGCGTTCTCCATTCTGGTTGCACCAGTTGAATCTGGTCCACCAAACGTAATGCGGGGTGCATTTCGCTGATTTTGGGGTCCATTATCGAACATTTTAGTTTGTTCGTTTAGATGAAATCTAAAACAACACGAACGTCATGATACTCTAAAAAGTCTTCATAGAACGAACAACGCACTACAAGACTACCCAATTTAGGTTCCTGGCAATTAATTGTAAAGGTAAACAGGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAAACCTTAGCAATACGTAAC ++ +)$$%$'%++-),4/=6:LKHD?FDCD5=3214@=<AF=BBBDCGF>=9D?@2$C>@:@?BDHFHAB1IG<:8A=?<=23799788<?AB37::(BA588**0;D;;4;?17446DG>468'(;DFH5/7/16:><<:<HB@JI<?BLC@><?-<;52(%'),&<;9=2<338;4)036-$%21)6BB@?A=??==77;2/:;=A9865655<,//-E:?9CEBDFEEFCTA=6*,-8:<B?BC7/.&&%0785//15=>JCDBB@BC:0:/;:<AC=><?@448)*7FA::?>===22==DCA/C.>?H505?@NJHC>C?GGE<;B?BC=43:>B;;576699'B>D@E>A;44:>=14@@>=373<HI?D@<AD6&>?FI:.(++-2>BHFA<=EE?FAFB79CB<D=E?8;9;CJIJD;?DABBGJFDB7>A@?B@:,@??)EFFDF@:?C?@A(<?JH:66?:7@B?C==EGIFJ;&221+229:A;200(*$ 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+$%,-486;=>:8GA)19>GFB>;>=:;/,**/0B?;;:,<?=B@61-($$'4:@FC@CEC@>155B?D<=<FIFB:9:B?B?B8<CE@CD<=9<@>?25'(<=>HAH?B6?3>9@A;@?@;/(>:68-16,4'42379=@:94-10)),(.2653)+-:>;3/-&)***55;@:>A<>A>>=EFEDD>78E?;CC@0+2,/?>B@E=@A<9<70@11CFIBJGGHIDFDC@CDF32;92/:6@B@585A3=><>@998;><6A6<>3CD@FDB88ABBE8;013@513*45:-*4,2,07<ACB=D?>==43/41:LG?B><99<CG=9A989/'%+0-15)*$$$*--0--/66000B6699:0/AACE<:;?CB-6&)),26%/9;?3.@FCA88D66<01A;CB8EGE?%*=@@9C>><855629DA460=9:B=/:A89??AGCACC>CBAJ?3>AADE=@A?B@?B;>;D@GEB9;98=:<;<C/1?@@?=6<;<::03/.))*( +@SRR11410539.2064609 2064609/1 +GCATAGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGGCCATTGGCGACCCTGCTCAATTACCACGCACATTTGCTAACTAAGGGCACACTAGAACCAGGATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGAGCACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTATTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAGAGGTGCTGTCGATTCCGTTTTGTAGTCGTCTGTTTAACTAGCAATACGTGGC ++ +####%#'%%(./4<*2(;GGH?CHGED3?8--:BFHFI@::9;5?:<3-766+-(-).8?9940>?<AAHKDHGH1:':>DJL95CEHB@A@7::,-0=8C;<A;=;D=A:./285+%&306*1@ABLIGD@48@./-2'.2++074@88:K=</,-96-.(5:723C>;B6>09969&<?DDBFF676:>559;<88,,1334@=;86;C87;:2282257;=5@B@>=@2?>D@D;>A=9:12>567')*/-*5;=9///7++)3=>A;;$$75.246932FLB=FGEC;=B=?<443DF>>@:?A=44/-/&8997<7AC:BAB6'%.7:F>B?<<>C:/03@=FBKI?:?%4&&<ACDLDCDIFD>EH@E:;:D<=4***))()47=48341-+&+'(*'0'.6563977A,?;A@=333,*2233AEEB=96'%90C@BB@?@C@5C;>?HAKC52=:7=9?BAD@CA:0**'018887302#%$ +@SRR11410539.1623861 1623861/1 +CATTGTACTTCGTTCAGTTACGTATTGTAAGGTTAAACAGACGACTAAAACGGAATCGACACGGCTTCCTTGGTATGACAACATTAGTTTGGCTGCTGTTGTAAGTGTTATGTTCAGGAACTTCAAACCATCTCTTGCATTGTTGATAATGTTGTTGGTACATCCATTATCCAACTTTCTAAGCATAGTGAAAAGCATTGTGCATAGCACTAGTAACTTTTGCCCTCTTGTCCTCAGATCTAGCCTGTTTATACATTTGGGTCCTTAGCTTGATCAGCCATCTTTTTCCAACTTACGTTGCATGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAGACTTCTTCAACTTTTTTAAGAACAACTTCAGAATCACCATTAGCAACAGCCATATAAGCTTCTTGAGCAGTAGCAAAAGCTGCACTATGATGGAAGGGAACAGGGTAACGCCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$#()053./1/,4-/'56;;93<323*)$%+>55;=;7031320('144/1/16;:95/-*+$'#$$%('**.,*)().*)*$$'*::AB1:>E=<=;34*)+,)3%$%#($4.'$'+*+$(*%$&'&'+%*,57637;AC4?B<<B8:::CA6?5'))%%)$$/-.+3&&F44BDF9;9;<7A@:@2>A883'$..*++@8:9=?<?/)($%-34BHKQGBHFFA8BA74;<,CFE3*E.G>A>=<AAA<:?68::5/65((1(.?;66BD@9?A9CGC?BE?BC@(,33332+:7DFA=90<>@FA@8::<>)-%*((&&.4615=HCA;93(;;C6--.-5;BB8FBD241AAGFDC=?:C4:--$%*357376><834012'4//1532)$$)*--2$$6@D@=<<.*2>>67==9):=<.93&;:BCAE3378.?708,'0-,&%&%'&/9<@E=?<ONI?>?<8512:<>HHH;;6666.:<89BDCC<41$, +@SRR11410539.157302 157302/1 +CAAGCGCATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTAAGCGTGTTGACTGGACTATATGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAGCACATAGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCCAAGCTGATGTAGAATGGAAGTTCTATGAGTCACTTTTGGCCATAAGTGACAAAGCTTATAAAATAAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCGGTTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACAT ++ +-&&$$#$'''*58?AF./$)()%($$%+.14851+=AGEH6=117487:976=<7>36-7>;?B?=CEFEEDGBDC-.CA=BB?:=;>A;<2,,&%&)&&'$#"$$)54./.4=>F==FCHB:<A?5CB>?67A:8>=4GEAAA<A1.&C?3*)#%,34-'=9>7:??A=D;BFGDDFA@=5234366.5;D@AG?<@=@ADD>;;;73.)+#%%-.AAA<FH?,%B:DD=><D?.9935;;(3$%%$(66;A@>=6F<=>/5AC>3.%#%$%$$&&()*+''##$,#&%2259CECA?A@A<FLCF:'))%%))$$+:A>A@@<<;;<:2588;'16312+-59>?C;=>31855;>11A@99BBBAICC?H>,..36=6@67>8453<><;G@E89?EDCGAC<?<4,,,+&,.)$%.007<ABAA;=3C7BG@AF-'@+::@@ADD2,371=>=7915'+15E>>F89>29FHAAJ;?E?>B<6@>DHB=<6A@HCCCB;>87879787))#$#%*,-..,' +@SRR11410539.802415 802415/1 +GTTGTACTTTGATTCAGATTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAAGGACGACAGCACCTCGTTCACCTAAGTTGGCGTATACGCGTAATATATCTGGGTTTTTCTACAAAATCATACCAGTCCTTTTATTGAAGTAATCCATCATCACAACAATTATATGACCAGTATTTCTTTTAATGTGTCACAATTACCTTCATCAAAATGCCTTAAAGCATAGACGGGTCTGCCATTGTGTATTTAGTAAGGCATTGACGACCATATAACGGTACCATGTCACCCGTCTATTCTAAACCCAAAGAAGTCATGTTTAGCAACAGCTGGACAAATCGCCTTAAGTAAATTATAAATTGTTTCAATATTTCATGTTTGGTAGTTAGAAAGTGTGTCTCTTAACTTTAAGTAAAGTCAATTAAATTGTCGTCCTTTTCTTGGAAGCGACAAAGGTGCTGTCGATTCCGTTTGCTTGGTCGTCTGTTTAGCGCCCGAAATACGTAGC ++ +'012-))**)*&()&&&'=>=<9/--67)$'01-?KFBDA<>>>=321)%*+.16$%,+#$$22=9@B?>>*>EABAA7=3858?8<>9@?=:CG?A5??75.,3>9=>BECK?79$&)89>@;;755895=00++1342212+'$**,''4)'7:4?;?559-.-,$$&*(($%/)0289?686550322;63;33;?9:/;:B<@<78>?=J=@==>??B4.7-15756%'::?=?BB=@E645*'36/)45233+'%$(.+(%%$'%&%&$$%&*)'78@??;??>A@;8<.)56&)56+.,,EF7/:8@?C=@<=>?9??:879GB;;9+*')&%-###$$68;??;33:>A37DFI=:;)0##/&4:A<=56A?455+$%$+&$+-'2;>/934@BCC>=((+&#%'0%')$'->@?B6;:<@8:46))1''')$%'&+&'(2<=;@@,/?A??A<7>?;;9$(09:.&$$&+/5:746,+%&$$$$$$%%%$$$''-,)''& +@SRR11410539.991348 991348/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTGCAAACGGAATCGACAGCACCTTGTTTATCACCCGCGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGAAGTGTCATGTTTTACTAAGAAGCTGTTGGTACAATTTACCTTTACAGCTAGAGTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAATCCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAGTAACT ++ +(&))*));<FBB@3=8AG9<<<BD?@,67-./?IGIJAB891+62,,-9@B==16/7<>BDDCCCB><>H@CDB946'78<..,-);99?>=?C=E:;;35:6FBD:<355BE?BADAC9FG?:?853++:B<7;13*$%%0:62$'.7*4A@9>:/,&$)),)-C6>>=?>>663?;:=&A8;I@80+5452D>EGDDA>2)9371+122798=G-;,>15:;9CA:?>B1CB8AFH;<=@@@@:9B@GC?,/50'>')'(:8;=BF6=89679;;:14*'&&3).)/9@DB?B<;A=/C@:;'$%'8<?B>>45.)@E=CA)*(0<?:5-/<9=GC>?D@=CC''>>D;8?@<=B@CFC411EA@;9,3577DF:)79;<=/=.EA1F/:G9;8<8B?>'788@DDEJE@@89A>?67E@A,47;@<<@A;57>B>2AIIEFLH9>99KFI?CAHF?<:00D@BC=>;D%;D;;?A>56DA>9:7;@?=<<:;CDNHB@9;=C856A;><>A@BDE@@@>;:B;<=;;?@AB-<('41'* +@SRR11410539.1845353 1845353/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACAGGAATGACAGCACCTCCATGGCGAATTCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTGTTTTTGTGCTTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTTCGAACTGTTTGCTGTTTACGCGTTTCCATGTGGTCATTCAATCCAGAAGAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +,+-.441:?3:<>8<3<KE>>@:888>?451BDCDF<@9:?9<<9;>:;94+'02)/22>:6<=A<;D<A:6(/9&&,5'9235(,3++7:48B<=:AA@>7<<=///99;52=<<4;45;:;?;:72532011+.4()'--:E?6-*9;@466/68<>05)7;853-47:+).+-*/HA=:DD66HEFE9=66@@4442FCLHE<89?DEBCDD776:A?@??VF766A8<B>@6:=@A<;;7/=A55/032'%$06>;EDB9A=789%4B>?>DB9B7;>?420099<=8A>D@/08/1.))078C@:A2>>??AEFMKB99?90,-.*55792?&1544/75/9=;&&-?5?D79@B?70/27=:BA>%#%$$&0+-7:5>>)-0+.+-*+6;@BAA56%%<54)'$&%%,67;>??>GC;7=$%*%>6::+)?9=:C=>C<7?HHC>283$+++',955C>9=@>?9.26A?JBF==9:;=?<=9;<B>>CCDAECAABAA:7$'# +@SRR11410539.298486 298486/1 +CGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAACGAATCGACAGCACCTTCACGCATGATCGTTCATGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACAAACTGTTGATTCATCACGGGGCTCAGAATATGACATGTCATATTCACTCAAACCACTGAAACGGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTCTTGAAATTCCACGTAGGAATGTGGCAGCTTTACAAGCTGAAAATGTAACCAGAGACTCTTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ 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+CGGTATTACTTCGTTCAGTTACGTATTGCTAAGGATTAAACAGACGACTGCTAAAAATAGATGTTGGCACCTACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAGCATTACCTAAAGGCATAATGATGAATGTCGCAAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCTATAATATGAGAGTTATACATTTGGTGCTGGTTCTGATAAAGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ 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+GCATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCGGTAATAAAGGAGCTGGTGGCCATGAATACAGCGCGATCTAAAATCATTGACTTAGGCGACGAGCTTAGCACTGATCATATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACGCTCGCTATGTCGTGCTTTTTAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGGGCTAACTGGACTTTATTGACACTAAGAGGAGATTGTATACTGCTGCCGTGAACATGAGCATGAAATTGGCAGTACACGGAACGTTCTGAAAGAGCTATGGTGCAGACACCTTGCCGGGCTGTCGTTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATCTTTCA ++ +%&%$%'(7:<?@C6:4;DB>>=:98<5<,56'6@<ADA;:;:BB@@BGFKMHD,2C@;:<97BCDFBB?EHKGDF<BC3965C?@47B?@@=8**$&($%$&+&),+(/%+,./%)(.3A==A><=CEC@:../--+('+-/.3+)C)C@<<<3?CRSL4<452'+BD;<=@>;4<?=JLC@<@A;515?;<?A71%9;>:=@>DAB@B@?B>:=@A8BACFD>@I34+483/+/$(9?67>770/-&&%%&&&&%(&%046722;<D<?BGHC@CBC-BEAD@>32*5DBDA>7)*&%$447?8:75;/45,?JCDD05>=?7,))0B?;4:$233?6))?)+*))=>=D>?7&'@HCKJFC>;>?GK9=@7)-&&.;=93*(37''5;>B@I>?>87//;744221.-3++,''+%()=CEIDD@A1<3;@=+'=FB?::%(90.(1'+&&(%&##$#$$,/./,$/3(,377E:90/061<=;A?@@66(*(-.13666<7%%%%%%## +@SRR11410539.1907056 1907056/1 +CAGTATGCTTCGTTCAGTTACACATTGCTAAGGTTAAGCAGACATTCTAAACGGAATCGACAACACCTTAAGGATCAGTGCCAAGCTCGTCGCCTAAGTCAAATGTTTCGGTCAGCGCCTTAACTGGCCCACCAGCTCCTTTATTACCGTTCATACGAAAGACCTTGCAGTACTGGTATTTCGCCCGCGGACAAAGGACACCGTGTCTCACCACTACGAATAATTGCTGAATGCCTTCGGGTTCTGCTATAAGCTCAACCATAACGCGACCATGGTTGAGTTGAGCATCGAACGTTTGATGAACACATAGGGCTGTTCAAGTTGAGGCAAAACGCCTTTTCAACTACTAAGCCACAAGTGCCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCCACGGAGTCTCCAAAGCCACGTACGAGCGTCGCGAACCTGTAAAACAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCCAATACTGGCAAC ++ +)%)%#*%015;7D=525=<4%0-((*+./..-??>56%+'**-'&(#'4551,/,12*''.)(&)2414117><7/*5A6?@673=>AB@GCGF?9<62<+1-)(&''%++%/+),)''$'$$$*.....**,.0=07:78<8441=B>F96'%$(,-0$%&%)$02)$++$#'$%0'6:49/.-'.2258411)89+$.22-;4026::;:'%%#&'(($#'$'&+)0++%%%&)(0)->87-1*))%$#$&1-:*+30/1000%%&$)+*+$'$%%$&(&76CD)%2,(*06@BC??9@463778.*//17<>=<<')058<6809BCECB;;98:C8<((()'588:')(3B>@7D1*.8<>=<DCDHGH@JDJHBDKF286;)00;:;@B?=C8<??E??*.$166:(:66635<2963/1223,/<?0086;@B><?CCE?>=9/3.AACG?9?>AEA69;A>G><H=;>98C=?=>KCA=A=;71'42/)($#$%$&'' +@SRR11410539.2148301 2148301/1 +GTTGTACTTCGTTCGAGACACGTATTGCTAAGGTTAAACGAAGACGACTACAAGCGAATCGACAGCACCTACAAACTGCCACCATCACAACCAGGCAAGTTAGGTTAGATAGCACTCTAGTGTCAAATCTACAAACAATGGAATTAGCAGGATATCTATCGACATTACAAAATTCAAAATGGCATACACCATCTGTGAATTTGTCAGAATGTGGCATAAGAATAGAATAATTCTTCTATTTTATAAGCTTTGTCACTACAAGGCTGTTGCATCATAGAACTTCCATTCTACATCAGCTTGAGTACACTTAATAGCTAGGGTTACCAATGTCGTGAAGAACTGAAATTTGTCTGCTAATAATGCAGCTTTAACAACCATGTGTTGAACCTTTTTACAAGCCGCATTAATCTTCAGTTCATCACCAATTATAGGATATTCAATAGATCCAGTCAACACGCTTAACAACGTTGCTGTCGATTCCGTTTAGTAGTCGTCTGTTTAACTAACTAACTA ++ +%..8=7;>88886..&/++;:9DE8=98C:;3HJF>>-'$#$%%::?:;A<77.*$%99?@EBI@=>==4<>CB:88420*15B<BF>;;;??AE??<C=3+2CA;126*1%*-72;074;2,*--48995=@A9BFB=BEE?CEB<3/<=A@<778;5/-2*+()%+%*'$*,$%&*'&$(.2265:89<7952:;;=DFH84>8=+=44-/.936-.12=6>0+@>:>:@AJBGD@C>:9C<9;0117AB@EFCFKB<<?63.*,2(/18=96=486##*24=<;C>C?@=/4+,,,/&1;;(D:;===18'%*$495BA?776580)13967802=7/4''%,06412+399?@://*(--79=?@=>B@@DA=76=<CBABB:;>?BA:,*02'/57923745'-C-A=ACB?<<>3.2%%%'479>=BA?A)655*/)$))4/27=CEAF<8'',3.($&&%$)))0'./<<A?=>:@>2+33>@<@>7A=@@??)(&*$%#$('#%+ +@SRR11410539.2352082 2352082/1 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+-&&%%$+()%##&)($(&),#)541.+-'&*,011'''%,034041:8,'%',+02550.,79-83*4(,489;9*<''=FB>:5:7DDB'7..)()'$%&#$',3B43+++(&%&&<?82+$/&%0$.&'%)/1,.;,$&'*(5>5'(-)*&),$()*'((5:2.&.01237=731'(%&)',5<,/&'+&&?655'3760.62&&;97777359,,6)+(''(*%(,,+1220++<+/13/2*&'''%$%%**&)%'&+$.01,)#%$&&(%(2,,,280+'#*'-)().*+.01:=B?/%.$''%52551.)),12-/(+*<9223019229))(,*&'89?>:7A()6978<3961//2*%&&;)1''3,++0)0+.,0*+***$)13+(/(+$68,-$&&'+-,...+*,.$(*$%$%%#$$(&),+%&%%$&$#$#$%$&'()))+/-*1(0078)#&###$'%,3559=32)56/'''+(4+'/0&%-)&$(,%%%($((,(()'')$ +@SRR11410539.365304 365304/1 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+GTTTACATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGATTACCAGAAGCAGCGTGCATAGCAGGGTCAGCAGCATACACAAGTAATTCCTTAAAACTAAGTCTAAGAGCTATGTAAGTTTACATCCTGATTATGTACAACACCTAGCTCTCTGAAGTGGTATCCAGTTGAAACTACAAATGGAACACCATCAACAAATATTTTCTCACTATTGGTCCAAAAACTTGTAGAGGAGTGGGAACACTGTAGAGAATAAAACATTAAAGTTTGCACAATGCAGAATGCATCTGTCATCAAACAGTTAACACAATTTGGGTGGTATGTCTGATCCCAATATTTAAAATAACGGTCCAAAGAGTTTTAACCTCTCTTCCGTGAAGTCATATTTTAACAAATCCCACTTAATGTAAGGCTTTGTTAAGTCAGTGTCAACAAGGTGCTGTCGATTGATTGTAGTCGTCTGTTTTAACCTTAGCAATACGTAACTTTT ++ +&/0)#$$$#8;>;AI3842@BG@<AKHH>;E>>.B<:;<D<<<<B???>9;AB<6586<:8<>52>@G?@EHDD>:?9>?6A297>5>99IGG@;6<==>A=742-877DC?EG=A576EEEBE28AABEHE;=CD=68>'(>@=@>=;=;9<6MJNEBB78B;:;<@><@CG;CFGEEAECDDF>F@BC=;?@129;((A>=A@C;CAADLDDFH?CE@99=<?50902178>=@HCLA>/=53*)%*23&&5??;9<@EG>+/%%))//;5859B@B9:=7974+1D>79BDFIHBAB)'>EJ<<:53303=?B<C;3BB>BC?=@.*;@A@DCCE@??C;C?@=?=2423/3=??D=C==<;?CFFF?D=;7=?=B<85>7=))=89%:;<FDG4++769?D=>A&/;BCB>?:AABEHB>;./;::8;>FD97<>AA>?@<<9;99=GD@D33/+0(,6(/:;<5<8+7A@B@<44,+1,%%+362)($99;@A>@=@7<=:;:9.))**,*023--(*+++ +@SRR11410539.290353 290353/1 +CATTGTACTTCGTTCCAGTTACGTATTGCTAAGTTAAACGGAGCTGACTACAAACGGAATCGACAGCACCTCATCAGGAGATGCCACAACTGCTTATGCTAACTAGTGGAGCAACATTTATTGGCTATTCTGACCAATGTTAATGCACTTTTATCTACTGATAGTAACAAAATTGCCGATAAGTATGTCCTGCAATTTGCACAGACTTTATGAGTGTCTCTATAAAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATGGCACTTATGCATCTCAAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACC ++ +$$)*)+'=AD>=ID%&+8BA<);6BCB>>:+)36<EGC7&*&'$$/)+'**1469132437;<71=@;=<>4146-A<:;;GB@>;;;<DH>89=G;=,0+**/1'$$'%&'((05=?70/5+1/*'$%$$($(,18559;4:.45,;ABJD;;3>=<A=>-)/75<@HJAH=HFEB9=<=><=;:8,,1$&(***.1'%&&&04=PNJE;((:?60/.74+1%&3;<6&%33><1@5=98A=?;92:<D17A5CBECHKEB8/2((:CBEDK?:::?6*<4BCJ?8D@A<:<)&(?>@F<;>>@<=33:47ABDG35>DD@A=B=<5%,/.()+00//,,,/,99&8B:A<<:A=?BCAIH52EH4(7;@DEA8:6;75;CC@HIKGFE;54BC=064311B?HGEF??<?:>6CB?FHHN<=ICADE?AICDC=@JH>AFJE@>@@6.>D?B==:;?@@HGOK><EB=B122236@>B<988878A60%89C8BC?=>:>?<>57;,--.-,&&&44?=;64*)%% +@SRR11410539.1559780 1559780/1 +TGTTGTACTTCCGTTCGGTTCAGTATTGCTAGGTTAAACAGACGACTACGAAGCAGATCGACAGCACCTCAGCCCCTATTAAACAGCCTGCGTGTTTGAAAAACATTAGAACCTGTAGAATAAACACGCCAAGTAGGAGTAAGTTGATCTGCGCCAGATAGCAACAGGGACTTCTGTGCAGTTAACACCCCCTGATAAAGAACAGCAACCTGGTTAGAAGTATTTGTTCCTGGTGTTATAACACTGACACCACCAAAAGTATGGTGTAATGTCAAGAATCTCAAGTGTCTGTGGATCACGGACAGCATCAGTAGTGTCAGCAATGTCTCTGCCAAATTGTTGGAAAGGCAGAAGCTTTTTGTTAGACTCAGTAAGAACACCTGTGCCTGTTAAACCATTGAAGTTGAAATTGACACATTTTGTTTTAACCAAATTAGTAGACTTTTAGGTCCACAAACAGTTGCTGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACA ++ 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+GTTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAAGCAGACGACTACAAACGGAATCGACAGCACCTAGCAAAATGTTGGACTGAGACTGACCTTACTAAGGACCTCATGAATTTTGCTCTCAACCTAATGCTAGTTAAGCTGGGGTGATTGATTATGTGTACCTTCACTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGACACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTCTGTACTTACAATACATAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTATTTATGCTTACTAATGATAACCACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCCAATACGTAACT ++ 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+GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTAAACGGAATCGACAGCACCTCTTTTCTCCAAGCAGGGTTACGTGTAAAGGAATTCTCTTACCACGCCTATTTGTGGCCTATTGTTTAGATGAAACATCATGCGTGATAACACCCTTATAAAACATTTTTAAAGCATTGAGCTGATTTGTCTTTATGTGCTTTAAGCTTATTATCATAAACCAAAGCACTCACAGTGTCAACAATTTCAGCAGGACAACGCCGACAAGTTCCGAGGAACATGTCTGGACCTATAGTTTTCATAAGTCTACACACTGAATTGAAATATTCTGGTTCTAGTGTGCCCTTAGTTAGCAATGTGCGTGGTGCAGGTAATTGAGCAGGGTCGCCAATGTACACATAGTGCTTAGCACGTAATCTGGCATTGACAACACTCAAATCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTCTGTTTAACCTTAGCAATACGTAACT ++ 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+CAAGCATGCTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACAGAATCGACAGCACTAGGACTGGTATGATTTTTGTAGAAAACCCAGATATATTACGCGTATACTTAACAGGTGAAGACGTGTGCACCAAGCACTGTTAAAAACGAGTACAAATTCTGTGATGCCATGCGAAATGCTGTGGTATTGTTGGTGTACTGACATTAGATAATCAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGAGTTCCCTATTGTAGATTCTTATTATTCATTATTCAATGCCTATATTAACCTTGACCGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACCTTAGCAATACACGTAAC ++ +4+*%&$%$:;@>>N05-=DCD>?<:9=;:->(AKEBC3:;:<==9<8>;236+%*:>3-)&'%%&'''&17B@DFIGFFHEEKQMJ@A5598=EHF;G:@6+2518@CDA?:5)'#$%%$%$%)3420$2/+.+-%0%,+*+-+++2*6<=>@B>6&&9??C;0+BBC<2@A@J?B>0/3:98=B23:=5+-4<8===AB=>9:8>;>GHGAFD66>6471.)()5=2A?FB:;=(-1>?BDDCCA?IDC=@BAAFNC9BAD@CD(@?B:<8-'-(.%%'+%7.*')$%%'(+/.1<@BCCGCFE;<<D;<<46)3;?@@B;HLFF>>=?BB?@;8*1%)*:;=9GH@CCA66=<<@<??BC@<C@=GD?MFASI@@CCE74@C:A:ABDD:;1,/4<,?CL?BB>@>D>==D4*5('33:<8;,2%/8B?A<>/C@CBHC:8486=JF?C>845?:;=':=BDLFAD>KCLBAI?88<@BCB@::14644588>;>>74+(1/0$$% +@SRR11410539.1057777 1057777/1 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+@SRR11410539.854400 854400/1 +GTTGTACTTCAGTTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGTCCACACTCTCCCTAGCACCATCATCATGCAGTTCTTGCTGTCGCAGGATTAATAAAAAACACTACAGCTGATGCATACATAACACAGTCTTTTAGCTTAAAACCAGACAAACTAGTATCAACCATATCCAACCATGTCATAATACGCATCACCCAACTAGCAGGCATATAGACCATATTAAAATAAGCTACAGTGGCAAGAGAAGGTAACAAAAACAAACAGAGAAATGCATGCTTATGTTTGACAAACATCATTGCAAAAGCAGACATAGCAATACCCATAGCAAAAAGGTAAGGCATTTTCATACAAAAAAAGAACAAAGACCATTGAGTACTCTGGACTAAAACTAAAGTGAAGTCAAAATTGTGAGTAACAACCAGTGGTGTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTTAACGCCAGCAATACATGCT ++ +'&''))))+$#'(,,?%,?=:?<FCCE=;:99/?A@=>$496;<=8=87;><:>9=<7;<>88323)*-.6//>1@17B<>/2/164<;20''.7?A9&&.0;9<<88268026))--<<=;(()%%...*.+))$(&)3145?78)&*&+(78;D:7:8;FEM;;3229BD;C>AGBF>KNB>??;<@?B01D@<9<44A?>:/4(*-35937696';2+69<BH;<@?=99:9AB::@??<;7:A@FFCEGHG=78;@?4403C<=@ED9;9>2:=A76516,5@>ABE?;:;30/E?+89>?>BCA?A7;FBFEEHGAB<<56701=?.-(1.2978+;)*..12893.'%',55,&%(93)))/;6:<D@<??D>FF@5-&$*+@=34++;//>B6:,14310-,:=B:>DFIF=<=>;+766574>:<:=>E978958>AB@@JFFCIAB:ABA@E;=FGB>:2C9:K@9<6<ED*)+/,<547+&()%%&%%&&%$%+*'&/(''$$ +@SRR11410539.1431913 1431913/1 +TGATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGGCTATAACAGAATCGACGCTTCCCTAGGCATGCCTTCTTACTGTACTGGTTACGAAGGCTATTGAACTACTAATGTCACTATTGCAACCTACTGCCTGGTTCTATACCGCTTGCAGTGTTGTCTTAGTGGTTTAGATTCTTTAGACACCCCTATCCTTCTTTAGAAACTATACAAATTAGTTTATCATCTTTAGTGATTTAACTGCTGTTGAATTTGCAGAGTGGTTTTTGCATGTATTCTTTTCACTAGGTTTTCTATGTACTTGGATTGGCTGCAATGTTACAAGTTGTTTTCAATATTTGCAGTACATTTTATTAGTAATTCTTGGCTTATATGTGGTTAATAATTAATCTTGTACAAATAGCCCCGATTTCAGCTAGTTAGAATGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTCATAGCTAATATAAGCAATCATATTTTTA ++ +#%(%%+)/0123@61))144>;?:D=-,2&&)*36@A?4+-,0%&)1+..-,&%8:81720*))+8:47<::C;=BDDGD@=3*53C959ACE>BB<((89<;1+*,/((('.7/=?9:;?=;6148*%-.>>2*,/))%++//03*100'0$#%&&%&+1%7@?<=83).:*.78.&&%)0-..)$%(*(*&&&*(++557756/1/%+4764)*,*+(&-$$%'('%)$'()+&*$,.*0</(()((&(&$()))/7;++4-*8:;=CDB=1%$##$(1:?>?EGB>A=@79:79E@@?901?:<=?:>=?@6;?=7:1/*$#%#(##$)64:9==:%%21:<=*.(+311115G=2/083;=A5<@>9/,"#%)$%%'$(.12124))%*,+-+.367:>>>9*%<:788<;8I,=5450(-25;7:>65436798<673/65@=+-)*-?23467+$()$)$&&$#%$%#$%&'$***(()&%/2=8*% +@SRR11410539.977310 977310/1 +GTTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACTAAACAGAATCGACAGCACCTACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTAGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGAGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCTATTTCAACGAGAAAACACACGATCAACTCCAGTTTGCCTGTTTTTACAGGTTCGCGACGTGCTCGTACGTGTGGCTTTGGAGACTCCGTGGAGGTCTTATCAGAGGCACGTCAGCATCTTAAAGATGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATCTTTTT ++ +'''(2):;<>??*3$'(,8>;FEFI8?9HH-DJIINJ?B?B;>:8.,$%128.&)*.6:>=0'(/(7)::ED==BA89?ADGC?G>BG?GF@)>(;<@FDDDG-:4MNBB98;/06EDGD?8<@:55'$/'42.;;>4BCDBDF=@=>78850=<BGF@@;13=9>FDKCF>G79;@<6==>=@;84,89;CD@01)151,&$)88::?@(%=)69:HFGKFEEEMEIB787+*2(3>BEMC?=?DAEC@B>0'BB@?>9<*%?9@??@CAB@=<DHDOI>''@)/C@@CCBA;99,'+<9<=>GJC3<-7=>?BG?66:2./22A333+(:8B@A<@8=G84+?89=9&<2?57LEFFNDHDMHB8C<EFGHEDEBG<8A:EH>6A;>-)(($'.23277675:=9<@GE:-3C=@?A;5901'.34,5+)23(1*;BF<JN=5;:A61931/8><@@A6D<??GDIB><::942@3=<BE9:;A<32)+*(%#$&&%&&''' +@SRR11410539.639972 639972/1 +CAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTCGAAAGCTATTAAACAGCCTGCACGTGTTTGAAAAACATTGGGAACCTGTAGAATAAACACGCCAAGTAGGGTAAGTTGATCTGCATGAATAGCAACAGGGACTTCTGTGCAGGGTGCTTTCACCCTGATAAAGAACAGCAACCTGGTTAGAAGTATTTGTTCTGGTGTTATAACACTGACACCACCAAAAGAACATGGTGTAATGTCAGAATCTCAAGTGTCTGTGGATCACGGACAGCATCAGTAGTGTCAGCAATGTCTCTGCCAAATTGTTGGAAAGGCAGAAACTTTTGATAGACTCAGTAAGAACACCTGTGCCTGTTAAACCATTGAAGTTGAAAATTGACACATTTGTTTTTAACCAAATTGAAATTAGACTTTTTAGGTCCACAAACAGTTGCTGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACATAGCAATACGTAAC ++ +%##&)./99;<@B?1)=C>6=;@DA?/4=887EFBEF=0')'%**/:98DE6**(+08=:=+<&7<<>::*+++-4&))+8;95=0=<DA?6<<?@<<669ICE<:@=:%)&956867.<-:=>;<..;=665'''9<8*2578:;>B?:=7=@<=<=B0:()))+0)=@A45:42,<,2$%.*8*)))*''//,/66A?@:+AI5<15,-88>:<E,B&/.7</>?C<?.?.,2=>@B99'(6;;;@5@B?D@7;DA-$'.98,879=;3./8-',A(01:=A@357<:<A=A<>@0*+''',?95D@1.9678;3@8463-1=<>?;>B?>3.6031164/469-3.)867370'$&/;42+3*+5:.:%&?11?C;8@:9@8AADDKFKIKPFB@//3BB;?B7024841478:5F<FIMA9;B@;---B@?11-%&%#$)$*$=??>;1+,:77;):AD@+$/&+==;79%&8A77;:8=@?@E?A>C?>1&++8=;:@AAGHE201(.055?AAE@=<70' +@SRR11410539.1100671 1100671/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCATTGTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGTAGTGCTTTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAAATCAGCTCAATGCTTTAAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAAGAATTCTTACGTAACCCTGCTTGGAAAAGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%',,/4656/77B56/?AD@B<B==>986)*8EHB=A?@BAC@@:=8:BCEAA47FE@2DFEDDCC3821=*;@47-?<(8>=:>67651/%%1)/;A>B:05>>7D<B<?++**4/0206:@DJECCEDH@34245=>:6@;58787*8AE1/:<?B>615;?;*51/0,1-(;@<AA<=DC/><=>/<8:68<?9586CTH@<;;KCC>A9?C@-%81<A>9?DHE78:9,0,1%%+53546>7?@577=?<>@?;<HHD7AC:7/87951%'%&3+02224359EDC?B@BE@AD89899:HLH7426;>./,,44<=C80=:8D8>:==>;=>@GPOHE?BCBFA>50'19??9@<:?A=:<<8:=51/<41.680..34)3674,15667;;=44-.063D-0412%2*033666?C??<=:;-,*4427878920)-0A<?@<;DADDB>A=KGHCC<=77>=>;?::CFF@BAGEABBA?D?=:..$$ +@SRR11410539.1398437 1398437/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAGCATCGACAGCACCTACAAAGAAAACAGTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTGCTGATGATTTAAACCAGTTAACTGGTTATAAAAACCTGCTTCAAGAGAGCAAGTTACATTTTCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACCCTCTTTTAAGAAGGAGAGGTGCTGTCGATTCCGTTTTGTAGTCGTCTGTTTAACATAGCAACCATGGC ++ +$#(+...24537A63,6<8?=<@==A=?9<:&)6G>:;$9=<=?6543*,+,%,/44<?B/GCCGAGC7?=%0BFF485;?7/98775./@=2();?><<;EF>51128@/0;=C:;C?**@;00$78FE@:9$$74.*+21<<A8=:5F>=?:613,/--.5?9;:=6%(&/*1,<;;?99;CD4<;<==@::%5DCEF?E::><,1.-?<<B<;89<=<EA%%>;=55(,355=A?;86>9:><62%&02<FB@A=<>?BGBDD1,>368:3))476A@BSIHCG=GJJGKCC?5::<@::=23-4'*(219@4<7(002*223-3+/8;88=NE?>@D;++0:<<86:>BFB?6@?B?C>=325=;@A@GAB<A<=<:1+BCA?<BBB803$*(+21)168ADBC3-::8<;@@5;;AB<8760.&(077874(*$'(0/201%%*#$%$ +@SRR11410539.1433222 1433222/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAAAAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGGTCAGAATAGTGCCATGGAGTGGCACGTTGAAGAATGTTAGTTTCTGGATTGAATGACCACATGGAACGCGTACGCGCAAACAGTCTGAAAGAAGCAATGAAGTAGCTGAGCCACATCAAACCTACAAGACAAGCCATTGCGATAGCAATTCCACCGGTGATCAATTTATTCTGTAAACAGCGGCAAGCACAAAACAAGCTAAAGTTACTGGCCTGCACAGCCAAGGAAAATTAACTTAATTATGCAAAACCTATTCCTGTTGGCATAGGCAAATTGTAGAAGACAAATCCATGTAAGGAATAGGAAACCTATTACTAGGTTCAATGTTTCAAGGAAGCTTTTTAAGCTCTTCAACGGTAATAGTACCGTTGGAATCTGCCATGGAAAGAAATTGCTGTCGATTCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +'(%%-23;?@42@@B<C<=8;<84(*3/*56/-+(&&<::BEAACCB@@;<==;980.&'14;<>@.5*3,8:579?<8D2:?642>9;<4915(;@8997A?A433%%+6(+.0*:;==D?<>7-2;;<@B@@D<A?;4768:.BA;4-0:=@EFD80378'1<F3.<67=89>:9.:>@<=<>1??>&;1/4*-&+*)3::<?><4;<EE9@KB@DFBJ>CAA>ABC?@>4<;>.&ECDDHHEDCCFC=864)*(8%-3;=5;,2AA9+:45598A;*/-/2>@5650/(#&&(&''88)30529:;40*00<><?1&&;88</216>?>+8E>?E@CLE=**=B?A@?@3')'2/8B>>>6$$5=@:1+)7=8:88:579/88/)++//,.0=D0:*+%%.0+%$%+**$)))))))*+)56<?<B>?D.495;864>7<98669<97<=B7>>8834+*'#&%$%),/0/:=>@G+*(%-:04**:?51B;EFGDDFA@?;59=43)//129;5* +@SRR11410539.906274 906274/1 +CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCAACACCTGTTGAGAGCAAGAATTCATGAGGTCCTTTTAGTAAGGTCAGTCTCAGTCCAACATTTTTGCTTCAGACATAAAAACATTGTTTTTATTAATAAAGAACTGACTTAAGTTCTTTATGCTAGCCACTAGACCTTGAGATGCATAAGTGCTATTGAAACACACAACAGCATCGTCAGAGTATCATCATTGAAATGTTTACGCAAATATGCGTAAAACTCATTCACAAAGTCTCTGTGTCGACATCTCTATTTCTATAGAGACACTCATAAAGTCTGTGTTGTAAATTGCGGACATACTTATCGGCAATTTTGTTACCATCAGTAGATAAAAGTGCATTAACATTGGCCGTGACAGCTTGACAAATGTTAAAACACTATTAGCATAAGCAGTTGTGGCATCTCTAAGGGAGGTTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +2#$%$$$*)(.%%,($2<?<@>ECCC<4D?@2===DF?:4423>?<<<E8:766:364./))*&1((++==B@@:?2/,-6)+$,+,0=78<7;9)*4*120+&3/0+91@<?9:;6.755AA@B=?EQNEB=A(50/AA=<<>CB>AGFI@C@HE;3-099;AB.:7B;?F@<FA>>9DF?DDF?&&33/1435(0<;@8:9998A:BBB9=7:;GB?B@E6D/F<>449B?4'9$8?:>;;5++,8853/;7-)+)'(*7:<B@3>;01@BAAE<<A>><?=B>C?A>=:;9BA84-4)))-3*&-%$'*//9<=?BC;@87,<+0354??2?-9<>;67>>>@EFH@A>>:;?/.46=2B@@;=>=7>18:FA=CMG?<??>>B=@682A4A;ECB58FD;767DFB--0&('%$$31<<E:<FFACACH:<D@;</.)+3<AGGCBJHDEFA>:<JI=??@>97<10)%&&1,*(7&*89C:6A>@G@,/7;@H<=A;6?=;<@A;<500-..3@:=BCAH:,.,1*- +@SRR11410539.225069 225069/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAATCGACAGCACCTAGATTCTTCCTTGCCATGTTGAGTGAGCGGTGAACCAAGACGCAGTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTGATCGCGCCCCACTGCGTTCTCCATTCTGGTTACTGCCAGTTGAATCTGAGGTCCGCAACGTAATGCGGGGTGCATTTCGCTGATTTTGGGGTCCATTATCAGACATTTTAGTTTGTTCGTTTAGATGGAAATCTAAAAAACAACTTTTACGAACATCATGATACTCTAAAGTCTTCCATAGAACGAACAACACTTTACAAGACTGCAATTTAGGTTCCTGGCAATTAATTGTAAAAGGTAAACAGGAAACTGTATAATTACGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACC ++ +*'().7155A<=L?3,8BD8<AJGFF??><1.>;;@D@/)*,)<6+A?=;;&3#$'(6=@E=@;CE?=2%%&%''26475?>BCGBIF?::>99+4/)/28,+('./.9@;714C@AB69305A:>A9;>9=)2@>;<=B><IIADAA?><74515658:76;:8;C-/2;@CEACC6:GE<@9AIE=AJB::;:=4>/0+00:)4%%03689BAA48C7DBD08;=>3.,0)+///%()7666,+-.+?89?@BFGJ;:7CDICAA6<D@><852$%?A><>6<=443210/%%%%%$),,30%10/:><8'%*=+GI05>BI@/562930*48456&&,$$$%'22<>>>?@8@>?@@@@<DHC=?G@??9:9=0205A?DE4%-65AD?/$%%;<79=<?CB,-+.%%&0/,4844B=B;=AHIHF>AF=ECTL>A:?B;757949;/.23@66FA;>CCE<:;<GGJ:;:94/';=4BCB-)376?=6@><=BBHB>54*. +@SRR11410539.1307255 1307255/1 +CAGTGTACTTCGTTCAGTTACGTATTGGAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACACAGACCATTCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAGTAAAAAATTTATCTAAGTCACTAGCTGAGAATAAATATTCTCAATTAGATGAAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTTAGAAGGTACAATTGCTTTTAAAGGAACCTTGCTCTTCTGGAACATACGAGGCATTCACCATTTCAAGGTGCTTTTGTCGATTCCGTTGTAGTCGTCTGTTCAACGCCCAGCAATATGGC ++ +-&&'&(&69;::D1,$-<==244<<A;0.?G?@B:<@ACAB>=;=936568;=4:<A?:845';:;0);2*+.:<=B';.15D5B;<JEEAGIJIJB7113?75>EEGAA<=C?A<C??5+,1<<AEHCDLF?@BAC=GBE;@II94,9@=<63<A:=61.0,5488<=;<567:338;<==@5,%+-//89/.FE@<?B?<==>;8778=?<:94;::;//==966:73),$,*/300/88-;>A>67,1265*6(5>C;<:<?:;@:=@;=787?95+8E@A@7&/4A>1177:99898:228=>D@?@6=..3650*+:CD8:9:<?C@@9;;349AA:?A@98,/2:;639@=@B6+1(3.:;<92>+2;975&'-$%'%%)5(1''.2-+((%&$56664;:<%'/-8<8A21:69>?<@CF>??<?67&+(.///79>A?FG-2%&*8<5)).>A:;=@=>;673<>>BC@;>5190,%&$((-)))&2&2$$#($*)' +@SRR11410539.728888 728888/1 +GTTGTACTTCGTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAAGTCGACAGCACCTACAAACTGCCACCATCACAACCAGGCCAAGTTAAGGTTAGATAGCACTCTAGTGTCAAATCTACAAACAATGGAATTAGCAGGATATCTATCGACATTGCAATTCCAAAATAGGCATACACCATCTGTGGTTGTCAGGAATGTGTGGCATAAGAATAGAATAATTCTTCTATTTTATAAGCTTTGTCACTACAAGGCTGTGCATCATAGAACTTCCATTCTACATCAGCTTGAGGTACACACTTAATAGCTTTAGGGTTACCAATGTCGTGAAGAAACTGGGAATTTGTCTGCTAATAATGCAGCTTTAACAACCATGTGTTGAACCTTTCTACAAGCCGCATTAATCTTCAGTTCATCACCAATTATGGAATGTTCAAATAGTCCAGTCAACACGCTTAACAAGGTGACGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'()(,+125032450+8:71''//12-08019<AAEH=8797:>>:84489$6&&(,4/,1C>BB@9=B?BB2::6?@CB<?=DEC01E>C8C2;:;>9B34.>A@A@>15(.-,09654C82;>?=<??@=CDE?BA;+,7ACA883/>@@B88CC@87>:<;@C;=<;77'6>@CB>228:-))'769@:==9;1-)1-%.$%%2=89;9>>@A<;*+(+?<C7;;?BCEB@JCGC@BBF@?<=?9;;>B;;==:;,,*,*4>9:;>96(&),365??BB;@A@AABBA<93,.$$$$#)9?=6B<7..374,,>?FE422<@B<*))79:>4,(7/,7087<5757?C@=?F>;<1.(%(()9;<=0*A@DC;((:44HDD>AHEDDBFI;<;;C@68243*463<..3==9=9,,'3;??@>@88@EFD?76$+.,$#67$68;<??,,><,(@C@9C:))>=CB),+&'#$##&$&,12>CDFIE=@=HDG:=D>>@;:AB9EDHFH73321/188-@GEB2,$ +@SRR11410539.1791086 1791086/1 +CAATGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACATTTAAGCAGGTGACACCTTCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAGAGAATTGCTTACACGTAACCCTGCTTGGAGAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAAGACCTTTATGACAAGTTGCAATTCCACAGAATCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTAGGTGCTGTCGATTTCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +.$%)),/5698<M8?8@AA:@<ABB?1>89;/DKHGK<A))6=-0,)12%/.-1%345E?AAA?78=<@EEAHE>?H@8AEFFDEC@CB:2$$*&;9;ABB>D?A==?7:*1('%&#$%$$..9$AC=BA@9=./879988>C*;11=>;55@A>877<=-00/8AGA?AB-,0B73<22>??=C;;9;>EF>)@IIOB;>CB<@CC>99B>ACD>79:12--=??::@:::@@D?92<-+.<=AC;6:@:93@2@D?-B)(0:02'<=:49:7?437-.2515:>GGA??A@F@89::;;6B;=;7-4HN99IG@?:69./(?B6DB0+)**)(*589&&';>A;B;<355B;@=;994;0514>@CAB;?=99;%3$%$$$$+*/(*'22'-989=D=8;<?A@?>$8E?>BFIF56567>>=>>:<:83@KJ>:35528;@5066?BHF>BDCD:57-,883/9:8D7;A82<9;?:==<<991:/01&'))'*2630/++ +@SRR11410539.928929 928929/1 +CGGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGAACGACTACAACAGATCGACAGCACCTAGCACATCACTACACCTTTAGATACATTTCTTTATTTAACAAAAAGGTGCACAGCGCAGCTTTCTTTAAAAAGTACTAAAGGAAACACCATTAAAGACTACACGTCTCTTTGGTGAAAGTACTAAAGAACCAATAGAAATGCTTTGTGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGTACTAAAGAGTGTGAACATAACCATCCACTGAATATGTGCTAAAAGAAACATCATTAGTAAGTGAAATGTCAAGTACAAGTAAATAACAGAATAGAAGCACCAGGTAAGAATGAGTAAACTGGTGTTAGAAGCAGAATACAGTGAGATGACATAAGGAATAGTAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAGGTGCTGTGATTCTTAGTAATCTGTTGCAACAGCAGCTAATACATGT ++ +4$%%#(&89<68@75*,@1@C=BB<A):A11/:GDAC;;&&.77;53(%''*,+;97=:543849:+'%$*,-&5%&+%**'(&)171=>BBBBCI?JGIDGFJ@@;66('')8?BG=::?;1-+&''(4346'?@9&&(;;<<BC00=:986;9;45787(9><=2.<;<:::<9<:(.*',(((A===GR,;=;&:8;:<9@CB228::D1ADG<B>BF?>?C9%%103*,$1?@>F=JH@((=8797464@<89-.('&)?:A==BBA9459<=:;@=<?CDJ@B=AG@@:FIF(%;:59@=@@D;057(&%)(*';8<8A<<<EE>=@:AGIEB967=73:6@/=>4>A=8@2?90-06>60/025DC?><>@E--4%&&&,-')&*69996<2)>;===24*3+<AD=@;>@A/8><=<;=,/,&01585.;987)4=7==6854900+7?<57+).-/0('$$('$$3:2.58)-/.0+((1$$&*)%%(+)&& +@SRR11410539.891112 891112/1 +CAGTATGCGCTACGTTCAGTTACGTATTGCTAAGGTTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGCGGCCTTCTGTAAAACACACCAGAAATTTTGAGCAGTTTCAAGAGTGCGGGAGAAAATTGATCGTACAACACGAAGGCAGCCTCTGATGCAAATGCATAAAGAGGACTCAGTATTGATTTCTGTTCACCAATATTCCAGGCACCTTTTTTAGCTTTTTCCTTTTTGTAACTTTAAAATTACCACAGGATTCAACAATTTGTTTGAATGCTTTTATAATCCAAACCTTTCACAGTTTCCACAAAGCACTTGTGGAAGCAGAAAAGATAGCAAAATAATGGCGGTCTTCATTGGTTAAAGTCACCAGCAATATTGATGTTGACTTTCTCTTTTTGGAGTATTTCAAGAAGGGTTAATATTAAGACCTTCGGAACCTTCTCCAACAACACCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCCTTAGCAATACGTAAC ++ 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2161861/1 +TGTTGTACTTCGTTCCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAAGCAAGATCGACAGCACCTCGGTAACTCTAAGGAGCTGGTGGCCCTTAGTTACGAAGGCGCCGATCTAAGGAAGATCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATCAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGTAACAACTTCTGTGGCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTTAGCACGTGCTGAGTAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAGTACTTGGTACACGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATATAA ++ 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+CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACACTTCCTTCCCATCTGGTAAAGTTGAGGTTTGTATGGTACAAGTAACTTGTGGTACAACTACGCTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCTTAGGACAGACTTTTTCAGTGTTAACTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTAGGTGCTGTCGGTCCGTTTTGACGGCTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +9+0,*,+/03/@N1<79BCBB@@@:;;@B9:3E@CDG:>88C@FFCD9+EE9>9<A@>?75+(###))17>@B?>B@@E@AF5<<;=0%),2@58?@?CCB@@>8?8879;842.)*0+*(/(.#%'*11B7;676>?22$$2>>@AD38365A>7*./+'=78=F?B8(657::83+*99626;<9@E?C:;//3<=KFEC:<28+8110=AGJ8/>C?;A?A::;<69;:>:3@.@>A<BNBAA145/11155:6;@>>?DHD@./;:$/6BCBKE==A67//09=A@86:9::165;+:+;:999>=5555BD$/D:94.''%''-07<89<@45295)/+>>?<C@C>A@CDF><16-18>;9++$%$%43>F<9;7=AAHE5<+/97&1&'#$+*/51@EFC@CH=E==<=@C<(+@D>=983989--A<DA8;>654.--@ACAB?7<@A@?@6@=>:=007632.0.++'$#$'-4:=@>;::><>59589<@CCBD?:5-,% +@SRR11410539.1083900 1083900/1 +GTTATTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACCCCCTATAACAGATCGACAGCACCTCGTGAAATTGGGCCTCATAGCACGTGTATTAAACACCAGATGGTGAACCATTGTAACAAGCTAACTAGAAAATCTGTCCTGGTTGATTACGAACAAACTTATACTTGGAATTTGTGTTAGGTTGGCTGTATCAACCTTAAGCTTAAGTACAATTTTGCATAGAATGTCCAATAACCCTGAGTTGAACATTACCAGCCTGTACCAAGAAATTATGATTAGACTTACGAATGAGTAAATCTTCATAATTAGGGTTAAGCATGTCTTCAGAGTGCAGATCACATGTCTTGGACAGTAGCTTCCTGATGTCATCAAGCCAAAGACCGTTGGTGTAGTTTGTACCACAAGTTACTTGTACCATACAACCCTCAACTTTACCAGATGGGAAGGTGCAATGATTCGTTTGTAGTCGTCTGTTTAACTTATACTTAATACATATT ++ +(%&##%*/;1+')/3279::;>62<89/@=;12,)%)$/'&(%%%#&%%''+),79::B3/57531$&&110,++)-15889?735)/0+$(%$&#%&(/8.,-2/:9682:/@4:=DDAGEA=22((/+*%%&#&&&%7989++.2,.9.*%%%$%%%)2./)%%%/))&'(&)#$$%&&&#.+)'6+/49/.,52/;896:9:7985585768-BCEAGOJ>@<=>=:@5567?&'#//5:B8;1?3@?==>====?;HDE<D>2-7:2.+35767(899KB=??;TI<==<A<89>;:<@=?IB7BAFGGFFECC=:/0*';72-*(')$$%*)%,443/4-2'$+78A>?@>+&$(+%$$%%)&)''&*51+<::7D@FG9,;;96<6#'+,+)8.5=(%%786>>>::0)278<52??..8;321'#(5269:<405<>9A<27<4;+0+%&&&&%%*.%%$4<94063-,0)@;;<=''&,-(%%$$$))%#$%#$%'
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/SRR11410539_seqtk_sample_500_1.fastq.consensus.fasta Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,500 @@ +>SRR11410539_seqtk_sample_500_1.fastq/ARTIC/medaka MN908947.3 +ANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/all_fasta.loc Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,7 @@ +# Tab separated with three columns: +# - value (Galaxy records this in the Galaxy DB) +# - dbkey (Database key) +# - name (Galaxy shows this in the UI) +# - path (the reference file) +# +test_entry test "Test Reference" ${__HERE__}/nCoV-2019.reference.fasta
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/gupplyplex_output.fastq Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,32 @@ +@9bd6c9e7-e630-471b-88f5-f0f46e5b3767 +CATCGGTGTTGGCCCGTTTCAGTTACGTAACCTACCAACCAGCTTTCGATCTCTTGTAGATCTATTCTCTAAACGAACTTTAAAATCTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAGTACTGTCGTCTGACAGGACGAAATAACTCGTCTATCTTCTGCAGGCTGTTACGGTTTTCGTCCGTGTACGGCCGATCATCAACACATCTAGGTTTGTCCGGGTGTGACGAAAATGAATGGAAGCCTTGTCCCCTGGTTTCAACGAGAAAACACGTCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCATGCGTGGCTTTGGAACTCCGTGGAGGTCTTATCAGGGCATCAGCATGTAAAGATGAGCAATACGTAACT ++ +'%*+%%&#$%%%((*,88):*-++*,'$$#$%$#++13/*(%$$&/7%'13)034)--2/,7'$798<@8:<D568;@BDCLG216A88#)-;6..1%##''))++$$--)*+&(.,,.>>A2/0//1124664;67:>6014*8315---&'%%%%%%.+$%%)*%'''(*.%''37A8I<87*.,/552)$&%%$&=AB>9200402)&%'&)454?;>--8+'),)/8B/0C:=HB1((>&+030DE,6'01**))'+&&'''.0,020//4.&0(*7?A0/.023(2.42-+.(%=1.;:A3'A:)976;.LLP*%(,%2@=61.0&,,4/?D=&&&)(...$$,7)-,'<<B57///+,4888@344&(&'$$.?2*./(%)//01<''%5;;:<<=6231%% 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.V1.bed Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,196 @@ +MN908947.3 30 54 nCoV-2019_1_LEFT 60 + +MN908947.3 385 410 nCoV-2019_1_RIGHT 60 - +MN908947.3 320 342 nCoV-2019_2_LEFT 60 + +MN908947.3 704 726 nCoV-2019_2_RIGHT 60 - +MN908947.3 642 664 nCoV-2019_3_LEFT 60 + +MN908947.3 1004 1028 nCoV-2019_3_RIGHT 60 - +MN908947.3 943 965 nCoV-2019_4_LEFT 60 + +MN908947.3 1312 1337 nCoV-2019_4_RIGHT 60 - +MN908947.3 1242 1264 nCoV-2019_5_LEFT 60 + +MN908947.3 1623 1651 nCoV-2019_5_RIGHT 60 - +MN908947.3 1573 1595 nCoV-2019_6_LEFT 60 + +MN908947.3 1942 1964 nCoV-2019_6_RIGHT 60 - +MN908947.3 1875 1897 nCoV-2019_7_LEFT 60 + +MN908947.3 2247 2269 nCoV-2019_7_RIGHT 60 - +MN908947.3 2181 2205 nCoV-2019_8_LEFT 60 + +MN908947.3 2568 2592 nCoV-2019_8_RIGHT 60 - +MN908947.3 2505 2529 nCoV-2019_9_LEFT 60 + +MN908947.3 2882 2904 nCoV-2019_9_RIGHT 60 - +MN908947.3 2826 2850 nCoV-2019_10_LEFT 60 + +MN908947.3 3183 3210 nCoV-2019_10_RIGHT 60 - +MN908947.3 3144 3166 nCoV-2019_11_LEFT 60 + +MN908947.3 3507 3531 nCoV-2019_11_RIGHT 60 - +MN908947.3 3460 3482 nCoV-2019_12_LEFT 60 + +MN908947.3 3826 3853 nCoV-2019_12_RIGHT 60 - +MN908947.3 3771 3795 nCoV-2019_13_LEFT 60 + +MN908947.3 4142 4164 nCoV-2019_13_RIGHT 60 - +MN908947.3 4054 4077 nCoV-2019_14_LEFT 60 + +MN908947.3 4428 4450 nCoV-2019_14_RIGHT 60 - +MN908947.3 4294 4321 nCoV-2019_15_LEFT 60 + +MN908947.3 4674 4696 nCoV-2019_15_RIGHT 60 - +MN908947.3 4636 4658 nCoV-2019_16_LEFT 60 + +MN908947.3 4995 5017 nCoV-2019_16_RIGHT 60 - +MN908947.3 4939 4966 nCoV-2019_17_LEFT 60 + +MN908947.3 5296 5321 nCoV-2019_17_RIGHT 60 - +MN908947.3 5230 5259 nCoV-2019_18_LEFT 60 + +MN908947.3 5620 5644 nCoV-2019_18_RIGHT 60 - +MN908947.3 5563 5586 nCoV-2019_19_LEFT 60 + +MN908947.3 5932 5957 nCoV-2019_19_RIGHT 60 - +MN908947.3 5867 5894 nCoV-2019_20_LEFT 60 + +MN908947.3 6247 6272 nCoV-2019_20_RIGHT 60 - +MN908947.3 6167 6196 nCoV-2019_21_LEFT 60 + +MN908947.3 6528 6550 nCoV-2019_21_RIGHT 60 - 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+MN908947.3 23122 23144 nCoV-2019_77_LEFT 60 + +MN908947.3 23500 23522 nCoV-2019_77_RIGHT 60 - +MN908947.3 23443 23466 nCoV-2019_78_LEFT 60 + +MN908947.3 23822 23847 nCoV-2019_78_RIGHT 60 - +MN908947.3 23789 23812 nCoV-2019_79_LEFT 60 + +MN908947.3 24145 24169 nCoV-2019_79_RIGHT 60 - +MN908947.3 24078 24100 nCoV-2019_80_LEFT 60 + +MN908947.3 24443 24467 nCoV-2019_80_RIGHT 60 - +MN908947.3 24391 24416 nCoV-2019_81_LEFT 60 + +MN908947.3 24765 24789 nCoV-2019_81_RIGHT 60 - +MN908947.3 24696 24721 nCoV-2019_82_LEFT 60 + +MN908947.3 25052 25076 nCoV-2019_82_RIGHT 60 - +MN908947.3 24978 25003 nCoV-2019_83_LEFT 60 + +MN908947.3 25347 25369 nCoV-2019_83_RIGHT 60 - +MN908947.3 25279 25301 nCoV-2019_84_LEFT 60 + +MN908947.3 25646 25673 nCoV-2019_84_RIGHT 60 - +MN908947.3 25601 25623 nCoV-2019_85_LEFT 60 + +MN908947.3 25969 25994 nCoV-2019_85_RIGHT 60 - +MN908947.3 25902 25924 nCoV-2019_86_LEFT 60 + +MN908947.3 26290 26315 nCoV-2019_86_RIGHT 60 - +MN908947.3 26197 26219 nCoV-2019_87_LEFT 60 + +MN908947.3 26566 26590 nCoV-2019_87_RIGHT 60 - +MN908947.3 26520 26542 nCoV-2019_88_LEFT 60 + +MN908947.3 26890 26913 nCoV-2019_88_RIGHT 60 - +MN908947.3 26835 26857 nCoV-2019_89_LEFT 60 + +MN908947.3 27202 27227 nCoV-2019_89_RIGHT 60 - +MN908947.3 27141 27164 nCoV-2019_90_LEFT 60 + +MN908947.3 27511 27533 nCoV-2019_90_RIGHT 60 - +MN908947.3 27446 27471 nCoV-2019_91_LEFT 60 + +MN908947.3 27825 27854 nCoV-2019_91_RIGHT 60 - +MN908947.3 27784 27808 nCoV-2019_92_LEFT 60 + +MN908947.3 28145 28172 nCoV-2019_92_RIGHT 60 - +MN908947.3 28081 28104 nCoV-2019_93_LEFT 60 + +MN908947.3 28442 28464 nCoV-2019_93_RIGHT 60 - +MN908947.3 28394 28416 nCoV-2019_94_LEFT 60 + +MN908947.3 28756 28779 nCoV-2019_94_RIGHT 60 - +MN908947.3 28677 28699 nCoV-2019_95_LEFT 60 + +MN908947.3 29041 29063 nCoV-2019_95_RIGHT 60 - +MN908947.3 28985 29007 nCoV-2019_96_LEFT 60 + +MN908947.3 29356 29378 nCoV-2019_96_RIGHT 60 - +MN908947.3 29288 29316 nCoV-2019_97_LEFT 60 + +MN908947.3 29665 29693 nCoV-2019_97_RIGHT 60 - +MN908947.3 29486 29510 nCoV-2019_98_LEFT 60 + +MN908947.3 29836 29866 nCoV-2019_98_RIGHT 60 -
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.reference.fasta Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,500 @@ +>MN908947.3 +ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCT +GTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACT +CACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATC +TTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTT +CGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAAC +ACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGG +AGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGG +CTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAA +ACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACT +CGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGG +CGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGG +TGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGA +TCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGA +ACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGG +CCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTC +ATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCG +TGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCA +GACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAA +TTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAA +GCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATG +CAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCA +GACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGA +AGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGC +ATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGG +CTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTC +TTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGG +TTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGA +AATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGA +GATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAA +AGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTAC +AAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCC +TCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCT +TGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGG +AATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTAC +TAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTG +GCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGA +AGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTAT +CTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAA +GGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTC +TATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCA +CTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCC +TCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTT +AACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGA +AGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGA +AATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATAC +CTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGA +AGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGT +ACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGC +CTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACC +ACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGG +TGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGA +AGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGA +AGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGA +AGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGA +CGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATT +AGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTT +AAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGT +AAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGC +AGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGC +TACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAA +ACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAA +GAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGG +TATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAA +TGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGA +AATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAA +GCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAAT +CAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAA +CTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAG +TGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCA +AGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAAT +GCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCA +GGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGC +CTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTC +TTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTG +TGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACA +AGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGC +GTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTA +TGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCC +AGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTC +TTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAA +AGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGA +TAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCAC +CTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTAC +AACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACA +ACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTC +ACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTT +TGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCA +CACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAA +CAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCC +ACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGC +ACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAAT +GAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTG +TAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGG +CACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACA +AGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGC +TCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCA +GTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTT +ACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAG +TTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAAT +TGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAAT +TGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATG +TGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTC +AAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTA +TAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTG +GCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTG +TCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGA +CGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGT +GGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGT +AGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCA +CACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGA +ATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAG +TGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTAC +AACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTT +CTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGC +ATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGA +GGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTG +GTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGT +TTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAA +CTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCT +TAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTC +ATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATAT +TCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAG +CTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGT +ACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTA +TGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTG +TTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAG +GTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTG +TGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGA +CTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGA +TAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGAC +TTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACAC +TAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATC +ATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACT +AGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGA +TGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACT +AGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTAC +TTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGT +TGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAA +CTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTAT +TGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGAT +ATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGC +TGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAA +TGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCA +GTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACC +TGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTAT +TGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGC +TGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCC +ATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCAC +GATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGT +TGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGC +TTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATA +TTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACAC +ACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTC +TGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATC +AGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAG +ATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTAC +ACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTAT +TGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGG +TGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACT +CTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTT +GACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTT +CACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCA +TTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTT +TAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAA +GTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAA +TAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTG +TCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACC +ACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCC +ATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGG +TCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACAT +GCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACA +GGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCT +TAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGG +ACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGC +TATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGG +TTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAAC +TGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCA +AACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTA +CGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGA +CTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACAT +ACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAA +AGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGA +TGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGT +GAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTT +AGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTT +ACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAA +GCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATAT +GGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATAC +TAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACT +AATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTAT +GAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTC +CATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCAT +GTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAAC +TGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTG +TTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGA +TTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAA +GAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTG +TATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTT +ACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGT +CCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGT +TTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGA +AGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCC +ATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGA +TTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGA +CCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAAT +GTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAAT +GCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGC +AAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGT +TGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGC +ATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAG +TGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAG +GGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGAT +GTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTA +CAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAA +ATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACC +TTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAA +AGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCT +ACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTT +TGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCAC +TAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACC +GGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTG +CCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAAT +ACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGT +CTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCA +GTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACA +CCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGAT +AAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGAC +GAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTAC +CAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGAC +TTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACT +AAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGAC +ACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAG +GACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAA +CGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGT +ATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGT +GATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTG +TTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGAC +TTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTA +AAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAAC +TGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTG +TTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTT +GTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAAC +TTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATG +CACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCA +CTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTAT +GACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTC +TTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTA +CCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTT +GATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAA +TCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGT +TATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACT +CAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTC +TCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCC +GCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAAC +ATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCT +AAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGC +AAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCT +CAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACC +TCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTC +ACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTC +CGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGAC +TTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGAC +GATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAG +AACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGG +ACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTT +AAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCC +GGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTG +TCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTC +TTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTA +GACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTT +TATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGC +AATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAA +TGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTAT +GTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATG +AGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAA +GTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCA +ATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAA +AGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCT +TATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAA +GTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACT +AAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCT +GTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACA +TCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGA +ATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAAT +TATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAG +AGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCT +TGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGAT +AAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTG +AATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCA +GATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAAT +GCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCA +CGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTT +ATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATT +GTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCA +GCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATT +AACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAA +GCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTA +CCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAA +ACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCA +AAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACA +AGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTC +TTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTC +AGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAG +GACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAAT +GGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATT +GGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTA +CAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACA +CCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAA +CACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTA +CAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCA +CATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGT +TGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGG +CATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGG +GGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCA +CATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTT +AAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCG +GCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCA +GTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAA +TGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTC +TATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGC +AATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCT +AACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCAC +ACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTAC +TCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCA +CTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCAT +GCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGC +TTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAG +AGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGT +GAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTA +GAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAG +CGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCT +GCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGT +GTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACT +GTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGT +GTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCT +AGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAG +AAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTA +CAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAA +TTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTT +AGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAA +TCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATA +ACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGAT +GATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTG +ACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACA +TTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTT +TACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCA +ACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTA +AACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCT +GATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTG +CTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGAT +TGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCT +AAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGT +GGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACAT +TCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTT +ACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAA +CCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACA +AATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTA +AGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTT +CTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTT +CTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAG +TCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCAC +ACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGA +CTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGAC +CAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGC +TTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAA +GACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATT +TCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGAT +GGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCA +GCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGT +GTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGT +GCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTAT +TAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGA +TTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAG +GACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACT +TGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTA +TCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTAC +AAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTG +GAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATC +ATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTAC +TAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGG +GCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGT +TATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTA +TAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTA +TCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACA +ATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACT +TTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTT +GGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTAC +TGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTAC +TGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGG +TGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCA +GGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTG +GCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGC +TGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAG +TTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCAT +TGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGC +CATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAA +GACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTT +GTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGA +ACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACC +AATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAG +CAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTT +CATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACA +AAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATA +CACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGC +ATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACA +GAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAA +AATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAA +CCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAAT +TTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAAT +TGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAAT +TAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGT +ACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCC +TCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAA +GAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGG +TGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACA +AATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGT +CAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGA +TAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAA +TGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTT +AAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCC +ATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTAT +GCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTG +CTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACAC +ATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAG +CAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCG +ATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTT +CAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGT +GTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTC +GTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAG +AGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAA +AACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTAT +TGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACA +AGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGA +GTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCA +ACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATT +GTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTT +AATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAA +GCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTA +ATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCC +ATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTA +AAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGAT +CTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAG +CCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAAT +GGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATG +CCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAG +TAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAA +TTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTT +TCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTC +TCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAA +TCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTG +ACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACA +AATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACA +GGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGC +TTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAG +ATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATA +AACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGAT +GAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTG +ATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTA +CTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTA +GCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGAC +GGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGA +CAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTT +ATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACT +TCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTT +GGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAAT +TTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTAC +AGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATT +CTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGG +ATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCT +GTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTT +CGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAA +CGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTAC +GTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCG +ATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCT +CACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACAC +CAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGG +TGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGG +GCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGA +GGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGC +AATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAG +CAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAA +TTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGA +TGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGG +TAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAA +GAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAG +ACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAAC +TGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGG +AATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGC +CATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCA +TATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGC +TGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCC +TGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTC +AACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGC +TTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGC +ACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTA +GGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGT +ACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAAT +TTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAA +AAAAAAAAAAAAAAAAAAAAAAA
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.scheme.V1.bed Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,196 @@ +MN908947.3 30 54 nCoV-2019_1_LEFT nCoV-2019_1 +MN908947.3 385 410 nCoV-2019_1_RIGHT nCoV-2019_1 +MN908947.3 320 342 nCoV-2019_2_LEFT nCoV-2019_2 +MN908947.3 704 726 nCoV-2019_2_RIGHT nCoV-2019_2 +MN908947.3 642 664 nCoV-2019_3_LEFT nCoV-2019_1 +MN908947.3 1004 1028 nCoV-2019_3_RIGHT nCoV-2019_1 +MN908947.3 943 965 nCoV-2019_4_LEFT nCoV-2019_2 +MN908947.3 1312 1337 nCoV-2019_4_RIGHT nCoV-2019_2 +MN908947.3 1242 1264 nCoV-2019_5_LEFT nCoV-2019_1 +MN908947.3 1623 1651 nCoV-2019_5_RIGHT nCoV-2019_1 +MN908947.3 1573 1595 nCoV-2019_6_LEFT nCoV-2019_2 +MN908947.3 1942 1964 nCoV-2019_6_RIGHT nCoV-2019_2 +MN908947.3 1875 1897 nCoV-2019_7_LEFT nCoV-2019_1 +MN908947.3 2247 2269 nCoV-2019_7_RIGHT nCoV-2019_1 +MN908947.3 2181 2205 nCoV-2019_8_LEFT nCoV-2019_2 +MN908947.3 2568 2592 nCoV-2019_8_RIGHT nCoV-2019_2 +MN908947.3 2505 2529 nCoV-2019_9_LEFT nCoV-2019_1 +MN908947.3 2882 2904 nCoV-2019_9_RIGHT nCoV-2019_1 +MN908947.3 2826 2850 nCoV-2019_10_LEFT nCoV-2019_2 +MN908947.3 3183 3210 nCoV-2019_10_RIGHT nCoV-2019_2 +MN908947.3 3144 3166 nCoV-2019_11_LEFT nCoV-2019_1 +MN908947.3 3507 3531 nCoV-2019_11_RIGHT nCoV-2019_1 +MN908947.3 3460 3482 nCoV-2019_12_LEFT nCoV-2019_2 +MN908947.3 3826 3853 nCoV-2019_12_RIGHT nCoV-2019_2 +MN908947.3 3771 3795 nCoV-2019_13_LEFT nCoV-2019_1 +MN908947.3 4142 4164 nCoV-2019_13_RIGHT nCoV-2019_1 +MN908947.3 4054 4077 nCoV-2019_14_LEFT nCoV-2019_2 +MN908947.3 4428 4450 nCoV-2019_14_RIGHT nCoV-2019_2 +MN908947.3 4294 4321 nCoV-2019_15_LEFT nCoV-2019_1 +MN908947.3 4674 4696 nCoV-2019_15_RIGHT nCoV-2019_1 +MN908947.3 4636 4658 nCoV-2019_16_LEFT nCoV-2019_2 +MN908947.3 4995 5017 nCoV-2019_16_RIGHT nCoV-2019_2 +MN908947.3 4939 4966 nCoV-2019_17_LEFT nCoV-2019_1 +MN908947.3 5296 5321 nCoV-2019_17_RIGHT nCoV-2019_1 +MN908947.3 5230 5259 nCoV-2019_18_LEFT nCoV-2019_2 +MN908947.3 5620 5644 nCoV-2019_18_RIGHT nCoV-2019_2 +MN908947.3 5563 5586 nCoV-2019_19_LEFT nCoV-2019_1 +MN908947.3 5932 5957 nCoV-2019_19_RIGHT nCoV-2019_1 +MN908947.3 5867 5894 nCoV-2019_20_LEFT nCoV-2019_2 +MN908947.3 6247 6272 nCoV-2019_20_RIGHT nCoV-2019_2 +MN908947.3 6167 6196 nCoV-2019_21_LEFT nCoV-2019_1 +MN908947.3 6528 6550 nCoV-2019_21_RIGHT nCoV-2019_1 +MN908947.3 6466 6495 nCoV-2019_22_LEFT nCoV-2019_2 +MN908947.3 6846 6873 nCoV-2019_22_RIGHT nCoV-2019_2 +MN908947.3 6718 6745 nCoV-2019_23_LEFT nCoV-2019_1 +MN908947.3 7092 7117 nCoV-2019_23_RIGHT nCoV-2019_1 +MN908947.3 7035 7058 nCoV-2019_24_LEFT nCoV-2019_2 +MN908947.3 7389 7415 nCoV-2019_24_RIGHT nCoV-2019_2 +MN908947.3 7305 7332 nCoV-2019_25_LEFT nCoV-2019_1 +MN908947.3 7671 7694 nCoV-2019_25_RIGHT nCoV-2019_1 +MN908947.3 7626 7651 nCoV-2019_26_LEFT nCoV-2019_2 +MN908947.3 7997 8019 nCoV-2019_26_RIGHT nCoV-2019_2 +MN908947.3 7943 7968 nCoV-2019_27_LEFT nCoV-2019_1 +MN908947.3 8319 8341 nCoV-2019_27_RIGHT nCoV-2019_1 +MN908947.3 8249 8275 nCoV-2019_28_LEFT nCoV-2019_2 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nCoV-2019_1 +MN908947.3 22262 22290 nCoV-2019_74_LEFT nCoV-2019_2 +MN908947.3 22626 22650 nCoV-2019_74_RIGHT nCoV-2019_2 +MN908947.3 22516 22542 nCoV-2019_75_LEFT nCoV-2019_1 +MN908947.3 22877 22903 nCoV-2019_75_RIGHT nCoV-2019_1 +MN908947.3 22797 22819 nCoV-2019_76_LEFT nCoV-2019_2 +MN908947.3 22798 22821 nCoV-2019_76_LEFT_alt3 nCoV-2019_2 +MN908947.3 23192 23214 nCoV-2019_76_RIGHT nCoV-2019_2 +MN908947.3 23189 23212 nCoV-2019_76_RIGHT_alt0 nCoV-2019_2 +MN908947.3 23122 23144 nCoV-2019_77_LEFT nCoV-2019_1 +MN908947.3 23500 23522 nCoV-2019_77_RIGHT nCoV-2019_1 +MN908947.3 23443 23466 nCoV-2019_78_LEFT nCoV-2019_2 +MN908947.3 23822 23847 nCoV-2019_78_RIGHT nCoV-2019_2 +MN908947.3 23789 23812 nCoV-2019_79_LEFT nCoV-2019_1 +MN908947.3 24145 24169 nCoV-2019_79_RIGHT nCoV-2019_1 +MN908947.3 24078 24100 nCoV-2019_80_LEFT nCoV-2019_2 +MN908947.3 24443 24467 nCoV-2019_80_RIGHT nCoV-2019_2 +MN908947.3 24391 24416 nCoV-2019_81_LEFT nCoV-2019_1 +MN908947.3 24765 24789 nCoV-2019_81_RIGHT nCoV-2019_1 +MN908947.3 24696 24721 nCoV-2019_82_LEFT nCoV-2019_2 +MN908947.3 25052 25076 nCoV-2019_82_RIGHT nCoV-2019_2 +MN908947.3 24978 25003 nCoV-2019_83_LEFT nCoV-2019_1 +MN908947.3 25347 25369 nCoV-2019_83_RIGHT nCoV-2019_1 +MN908947.3 25279 25301 nCoV-2019_84_LEFT nCoV-2019_2 +MN908947.3 25646 25673 nCoV-2019_84_RIGHT nCoV-2019_2 +MN908947.3 25601 25623 nCoV-2019_85_LEFT nCoV-2019_1 +MN908947.3 25969 25994 nCoV-2019_85_RIGHT nCoV-2019_1 +MN908947.3 25902 25924 nCoV-2019_86_LEFT nCoV-2019_2 +MN908947.3 26290 26315 nCoV-2019_86_RIGHT nCoV-2019_2 +MN908947.3 26197 26219 nCoV-2019_87_LEFT nCoV-2019_1 +MN908947.3 26566 26590 nCoV-2019_87_RIGHT nCoV-2019_1 +MN908947.3 26520 26542 nCoV-2019_88_LEFT nCoV-2019_2 +MN908947.3 26890 26913 nCoV-2019_88_RIGHT nCoV-2019_2 +MN908947.3 26835 26857 nCoV-2019_89_LEFT nCoV-2019_1 +MN908947.3 26838 26860 nCoV-2019_89_LEFT_alt2 nCoV-2019_1 +MN908947.3 27202 27227 nCoV-2019_89_RIGHT nCoV-2019_1 +MN908947.3 27190 27215 nCoV-2019_89_RIGHT_alt4 nCoV-2019_1 +MN908947.3 27141 27164 nCoV-2019_90_LEFT nCoV-2019_2 +MN908947.3 27511 27533 nCoV-2019_90_RIGHT nCoV-2019_2 +MN908947.3 27446 27471 nCoV-2019_91_LEFT nCoV-2019_1 +MN908947.3 27825 27854 nCoV-2019_91_RIGHT nCoV-2019_1 +MN908947.3 27784 27808 nCoV-2019_92_LEFT nCoV-2019_2 +MN908947.3 28145 28172 nCoV-2019_92_RIGHT nCoV-2019_2 +MN908947.3 28081 28104 nCoV-2019_93_LEFT nCoV-2019_1 +MN908947.3 28442 28464 nCoV-2019_93_RIGHT nCoV-2019_1 +MN908947.3 28394 28416 nCoV-2019_94_LEFT nCoV-2019_2 +MN908947.3 28756 28779 nCoV-2019_94_RIGHT nCoV-2019_2 +MN908947.3 28677 28699 nCoV-2019_95_LEFT nCoV-2019_1 +MN908947.3 29041 29063 nCoV-2019_95_RIGHT nCoV-2019_1 +MN908947.3 28985 29007 nCoV-2019_96_LEFT nCoV-2019_2 +MN908947.3 29356 29378 nCoV-2019_96_RIGHT nCoV-2019_2 +MN908947.3 29288 29316 nCoV-2019_97_LEFT nCoV-2019_1 +MN908947.3 29665 29693 nCoV-2019_97_RIGHT nCoV-2019_1 +MN908947.3 29486 29510 nCoV-2019_98_LEFT nCoV-2019_2 +MN908947.3 29836 29866 nCoV-2019_98_RIGHT nCoV-2019_2
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/primer_scheme_bedfiles.loc Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,6 @@ +# Tab separated with three columns: +# - value (Galaxy records this in the Galaxy DB) +# - name (Galaxy shows this in the UI) +# - path (the primer scheme bedfile) +# +test_entry "Test Database" ${__HERE__}/nCoV-2019.scheme.V1.bed
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/test.fastq Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,40 @@ +@8db09f2a-de97-4ebd-80ac-fdd69d356cad +TGGTCCATGTAACTACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTTAAAATCTGTGTGGCTGTCCTCCGGCTGCATGCTTAGTGCCACTCACGCAGTATAATTAATATTAATTACTGTCGTTGACAGGACCTTTTTGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTTTGTCGATCATCAACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAGATGGAGAGCCTTGTCCCTGGA ++ +%&%$&$$##$$((%'(:7=@8,>@@C=DB;;>EG;:44456<7CC=<4:)21'-,,06::93;?@?9:=5:3<>?@B?+,0053%(&$$)566)*-)7<9//(&.=0.))*)44;CA@>94--%%21-.77;?=@3*19-((?6$/0/1322(#3572:;??<?ADDFJI?>??@AACFB@LGCADNBQK=?;<@>A@B<.,0%5676830370128=75A<COI;=++A6,-/.D@=DGB>?C;942(+--.-,*423/<=<>=42))&# +@9518353b-8dcc-460f-9801-2be35ffc6a19 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+AAACGTACTTCGTTCAGTTACGTATTGCTAACCAACCAACTTTCGATCTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCCGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAATATTATCTTCTTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTGTGATTGTGACCGAAGGTAAGATGGAGAGCCTTGTCCCTAGTTTCAACGAGAAAACACACGTCAACTCAGTTTGCCTCTTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGAGCAATACGTAACTGA ++ +(($%%$#$*/39A9C4:=:''$''&'27,53-/%((,-,$$-3732/12$*120*((6@BFFB*MIE1113667+6;@@;;;-$,6077831;13;7)'%+*,-5&#&--:1+/**9;/*435BDDFA=>@@AG;4:>83:>>C@<C=JG9;99GG<8221.**)&')&*7??=90+''(()8/165AA><--8<8%,4496?866>;;A@:<9:<5/<<$8@(;4>1/.8,>,$%$%)+-=><?@:+*&%;9>?C??C>8DF=>?=:226&%$*0026<3476,718:66/,*.&5>;A=<1:38-&''+&'*==89878CFE7//3-4*56>?9*5598..0101(%(*.;9;9410.0*%$2<?@@??97<47,+>AB:;:CC@>ABFF?D<;;8001ACC5665.))($$##
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool-data/all_fasta.loc.sample Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,18 @@ +#This file lists the locations and dbkeys of all the fasta files +#under the "genome" directory (a directory that contains a directory +#for each build). The script extract_fasta.py will generate the file +#all_fasta.loc. This file has the format (white space characters are +#TAB characters): +# +#<unique_build_id> <dbkey> <display_name> <file_path> +# +#So, all_fasta.loc could look something like this: +# +#apiMel3 apiMel3 Honeybee (Apis mellifera): apiMel3 /path/to/genome/apiMel3/apiMel3.fa +#hg19canon hg19 Human (Homo sapiens): hg19 Canonical /path/to/genome/hg19/hg19canon.fa +#hg19full hg19 Human (Homo sapiens): hg19 Full /path/to/genome/hg19/hg19full.fa +# +#Your all_fasta.loc file should contain an entry for each individual +#fasta file. So there will be multiple fasta files for each build, +#such as with hg19 above. +#
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool-data/primer_scheme_bedfiles.loc.sample Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,8 @@ +# this is a tab separated file describing the location of primer schemes used for amplicon +# sequencing (e.g. using the ARTIC SARS-CoV-2 protocol) +# +# the columns are: +# value description path +# +# for example +# SARS-CoV-2-ARTICv1 SARS-CoV-2 ARTIC v1 primers /data/galaxy/tool_data/artic_primers/SARS-CoV-2-ARTICv1.bed
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.sample Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,13 @@ +<?xml version="1.0"?> +<tables> + <!-- Locations of primer scheme bedfiles in the required format --> + <table name="primer_scheme_bedfiles" comment_char="#" allow_duplicate_entries="False"> + <columns>value, description, path</columns> + <file path="tool-data/primer_scheme_bedfiles.loc" /> + </table> + <!-- Locations of reference fasta files --> + <table name="all_fasta" comment_char="#"> + <columns>value, dbkey, name, path</columns> + <file path="tool-data/all_fasta.loc" /> + </table> +</tables>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.test Fri Aug 27 20:34:52 2021 +0000 @@ -0,0 +1,12 @@ +<?xml version="1.0"?> +<tables> + <!-- Locations of primer scheme bedfiles --> + <table name="primer_scheme_bedfiles" comment_char="#"> + <columns>value, name, path</columns> + <file path="${__HERE__}/test-data/primer_scheme_bedfiles.loc" /> + </table> + <table name="all_fasta" comment_char="#"> + <columns>value, dbkey, name, path</columns> + <file path="${__HERE__}/test-data/all_fasta.loc" /> + </table> +</tables>