Mercurial > repos > iuc > cemitool
diff test-data/pathways.gmt @ 0:3f9ff31c88bb draft
planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/cemitool commit 07372bcbc3a94f886436a7263f4cfcb01981c7f3
| author | iuc |
|---|---|
| date | Mon, 10 Oct 2022 16:55:19 +0000 |
| parents | |
| children |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/pathways.gmt Mon Oct 10 16:55:19 2022 +0000 @@ -0,0 +1,1650 @@ +NS1 Mediated Effects on Host Pathways Reactome Pathway CPSF4 EIF2AK2 NS PABPN1 +2-LTR circle formation Reactome Pathway BANF1 HMGA1 LIG4 PSIP1 XRCC4 XRCC5 XRCC6 gag gag-pol rev vif vpr vpu +3' -UTR-mediated translational regulation Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H FAU PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +5-Phosphoribose 1-diphosphate biosynthesis Reactome Pathway PRPS1 PRPS1L1 PRPS2 +A tetrasaccharide linker sequence is required for GAG synthesis Reactome Pathway AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GXYLT1 GXYLT2 HSPG2 NCAN SDC1 SDC2 SDC3 SDC4 VCAN +A third proteolytic cleavage releases NICD Reactome Pathway APH1A APH1B NCSTN NOTCH1 NOTCH2 NOTCH3 NOTCH4 PSEN2 PSENEN +ABC-family proteins mediated transport Reactome Pathway ABCA10 ABCA12 ABCA2 ABCA3 ABCA4 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB5 ABCB6 ABCB7 ABCB8 ABCC1 ABCC10 ABCC11 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 ABCD2 ABCD3 ABCG1 ABCG4 ABCG5 ABCG8 APOA1 CFTR PEX19 PEX3 +ABCA transporters in lipid homeostasis Reactome Pathway ABCA10 ABCA12 ABCA2 ABCA3 ABCA6 ABCA7 ABCA9 ABCD1 ABCD2 ABCD3 ABCG1 ABCG4 ABCG5 ABCG8 APOA1 PEX19 PEX3 +ABH2 mediated Reversal of Alkylation Damage Reactome Pathway ALKBH2 +ABH3 mediated Reversal of Alkylation Damage Reactome Pathway ALKBH3 +ADP signalling through P2Y purinoceptor 1 Reactome Pathway GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK14 P2RY1 PLA2G4A SRC +ADP signalling through P2Y purinoceptor 12 Reactome Pathway GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 P2RY12 +AKT phosphorylates targets in the cytosol Reactome Pathway AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK GSK3A GSK3B MDM2 TSC2 +AKT phosphorylates targets in the nucleus Reactome Pathway AKT1 AKT2 AKT3 CREB1 FOXO1 FOXO3 FOXO4 NR4A1 RPS6KB2 +AKT-mediated inactivation of FOXO1A Reactome Pathway AKT1 AKT2 AKT3 FOXO1 +AMER1 mutants destabilize the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +AMPK inhibits chREBP transcriptional activation activity Reactome Pathway MLXIPL PRKAA2 PRKAB2 PRKAG2 STK11 +APC truncation mutants are not K63 polyubiquitinated Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +APC truncation mutants have impaired AXIN binding Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +APC-Cdc20 mediated degradation of Nek2A Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 NEK2 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC/C-mediated degradation of cell cycle proteins Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC/C:Cdc20 mediated degradation of Cyclin B Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC/C:Cdc20 mediated degradation of Securin Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDC26 CDC27 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC/C:Cdc20 mediated degradation of mitotic proteins Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB CDC16 CDC20 CDC23 CDC26 CDC27 FZR1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +APOBEC3G mediated resistance to HIV-1 infection Reactome Pathway APOBEC3G BANF1 HMGA1 PPIA PSIP1 gag gag-pol rev vif vpr vpu +ARL13B-mediated ciliary trafficking of INPP5E Reactome Pathway ARL13B INPP5E PDE6D +ARMS-mediated activation Reactome Pathway BRAF CDK1 CRK HRAS IL6 IL6R IL6ST JAK1 JAK2 KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 PTPN11 RAF1 RAP1A TYK2 YWHAB +ATF4 activates genes Reactome Pathway ASNS ATF3 ATF4 ATF6 CCL2 CXCL8 DCP2 DDIT3 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 IGFBP1 IL8 KHSRP NFYA NFYB NFYC PARN +ATF6-alpha activates chaperone genes Reactome Pathway ATF4 ATF6 CALR DDIT3 HSP90B1 HSPA5 NFYA NFYB NFYC XBP1 +ATF6-alpha activates chaperones Reactome Pathway ATF4 ATF6 CALR DDIT3 HSP90B1 HSPA5 MBTPS1 MBTPS2 NFYA NFYB NFYC XBP1 +ATM mediated phosphorylation of repair proteins Reactome Pathway ATM BRCA1 H2AFX MDC1 NBN +ATM mediated response to DNA double-strand break Reactome Pathway ATM BRCA1 H2AFX MDC1 NBN +ATP sensitive Potassium channels Reactome Pathway ABCC8 ABCC9 KCNJ11 KCNJ8 +AUF1 (hnRNP D0) destabilizes mRNA Reactome Pathway EIF4G1 HNRNPD HSPA1A HSPA8 HSPB1 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +AXIN missense mutants destabilize the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +AXIN mutants destabilize the destruction complex, activating WNT signaling Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Abacavir metabolism Reactome Pathway ADAL ADH1A GUK1 NT5C2 PCK1 +Abacavir transmembrane transport Reactome Pathway ABCB1 ABCG2 SLC22A1 SLC22A2 SLC22A3 +Abacavir transport and metabolism Reactome Pathway ABCB1 ABCG2 ADAL ADH1A GUK1 NT5C2 PCK1 SLC22A1 SLC22A2 SLC22A3 +Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate Reactome Pathway IDH1 +Abnormal metabolism in phenylketonuria Reactome Pathway CCBL1 IL4I1 LDHB PAH +Abortive elongation of HIV-1 transcript in the absence of Tat Reactome Pathway CTDP1 GTF2F1 GTF2F2 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT4H1 SUPT5H +Acetylation Reactome Pathway NAT1 NAT2 +Acetylcholine Binding And Downstream Events Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG +Acetylcholine Neurotransmitter Release Cycle Reactome Pathway BZRAP1 CHAT CPLX1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A3 SLC5A7 SNAP25 STX1A STXBP1 SYT1 UNC13B VAMP2 +Acetylcholine regulates insulin secretion Reactome Pathway CHRM3 GNA11 GNA14 GNA15 GNAQ MARCKS PLCB1 PLCB2 PLCB3 PRKCA +Acrosome Reaction Reactome Pathway ACR +Activated NOTCH1 Transmits Signal to the Nucleus Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CNTN1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 ITCH JAG1 JAG2 MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RPS27A UBA52 UBB UBC +Activated TLR4 signalling Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 BTK CASP8 CD14 CD36 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FADD FOS HMGB1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR6 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 porB +Activated point mutants of FGFR2 Reactome Pathway FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 +Activation and oligomerization of BAK protein Reactome Pathway BAK1 BID +Activation of AMPA receptors Reactome Pathway GRIA1 GRIA2 GRIA3 GRIA4 +Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Activation of ATR in response to replication stress Reactome Pathway ATR ATRIP CDC25A CDC25C CDC45 CDC6 CDC7 CDK2 CHEK1 CLSPN DBF4 HUS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RAD1 RAD17 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Activation of BAD and translocation to mitochondria Reactome Pathway AKT1 AKT2 AKT3 BAD BCL2 BID PPP3CC PPP3R1 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Activation of BH3-only proteins Reactome Pathway AKT1 AKT2 AKT3 BAD BBC3 BCL2 BCL2L11 BID BMF DYNLL1 DYNLL2 E2F1 MAPK8 PMAIP1 PPP3CC PPP3R1 SFN TFDP1 TP53 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Activation of BIM and translocation to mitochondria Reactome Pathway BCL2L11 DYNLL1 MAPK8 +Activation of BMF and translocation to mitochondria Reactome Pathway BMF DYNLL2 MAPK8 +Activation of C3 and C5 Reactome Pathway C2 C3 C4A C4B C5 CFB +Activation of Ca-permeable Kainate Receptor Reactome Pathway CALM1 DLG1 DLG3 DLG4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD +Activation of CaMK IV Reactome Pathway CALM1 CAMK4 +Activation of DNA fragmentation factor Reactome Pathway CASP3 DFFA DFFB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 +Activation of G protein gated Potassium channels Reactome Pathway GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +Activation of GABAB receptors Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GABBR1 GABBR2 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Reactome Pathway CD14 IKBKE IRF3 IRF7 LY96 PTPN11 RPS27A SARM1 TANK TBK1 TICAM1 TICAM2 TLR3 TLR4 TRAF3 UBA52 UBB UBC +Activation of Kainate Receptors upon glutamate binding Reactome Pathway CALM1 DLG1 DLG3 DLG4 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD PLCB1 PLCB2 PLCB3 +Activation of Matrix Metalloproteinases Reactome Pathway CMA1 COL18A1 CTRB1 CTRB2 CTSG CTSK CTSV ELANE FURIN KLK2 KLKB1 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 PLG PRSS1 PRSS2 TIMP1 TIMP2 TPSAB1 +Activation of NF-kappaB in B cells Reactome Pathway BCL10 BTRC CARD11 CHUK CUL1 FBXW11 IKBKB IKBKG MALT1 MAP3K7 NFKB1 NFKBIA NFKBIB NFKBIE PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 REL RELA RPS27A SKP1 UBA52 UBB UBC +Activation of NIMA Kinases NEK9, NEK6, NEK7 Reactome Pathway CCNB1 CCNB2 CDK1 NEK6 NEK7 NEK9 PLK1 +Activation of NMDA receptor upon glutamate binding and postsynaptic events Reactome Pathway ACTN2 ADCY1 ADCY3 ADCY8 AKAP9 BRAF CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CREB1 DLG4 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 PRKACA PRKACB PRKACG RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +Activation of NOXA and translocation to mitochondria Reactome Pathway E2F1 PMAIP1 TFDP1 TP53 +Activation of Na-permeable Kainate Receptors Reactome Pathway GRIK1 GRIK2 +Activation of Nicotinic Acetylcholine Receptors Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG +Activation of PKB Reactome Pathway AKT2 PDPK1 THEM4 TRIB3 +Activation of PPARGC1A (PGC-1alpha) by phosphorylation Reactome Pathway MAPK11 MAPK12 MAPK14 PPARGC1A PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 +Activation of PUMA and translocation to mitochondria Reactome Pathway BBC3 E2F1 TFDP1 TP53 +Activation of RAS in B cells Reactome Pathway HRAS KRAS NRAS RASGRP1 RASGRP3 +Activation of Rac Reactome Pathway GPC1 NCK1 NCK2 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 RAC1 ROBO1 SLIT2 SOS1 SOS2 +Activation of SMO Reactome Pathway ADRBK1 ARRB1 ARRB2 BOC CDON CSNK1A1 DHH EFCAB7 EVC EVC2 GAS1 GAS8 IHH IQCE KIF3A PTCH1 SHH SMO +Activation of TRKA receptors Reactome Pathway ADCYAP1 ADCYAP1R1 ADORA2A NGF NTRK1 NTRK2 +Activation of caspases through apoptosome-mediated cleavage Reactome Pathway APAF1 CASP3 CASP7 CASP9 CYCS +Activation of gene expression by SREBF (SREBP) Reactome Pathway ACACA ACACB CARM1 CHD9 CREBBP CYP51A1 DHCR7 ELOVL6 FASN FDFT1 FDPS GGPS1 GPAM HELZ2 HMGCR HMGCS1 IDI1 LSS MED1 MVD MVK NCOA1 NCOA2 NCOA6 NFYA NFYB NFYC PMVK PPARA RXRA SC5D SC5DL SMARCD3 SP1 SQLE SREBF1 SREBF2 TBL1X TBL1XR1 TGS1 TM7SF2 +Activation of the AP-1 family of transcription factors Reactome Pathway ATF2 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 +Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H FAU PABPC1 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA +Activation of the phototransduction cascade Reactome Pathway CNGA1 CNGB1 GNAT1 GNB1 GNGT1 PDE6A PDE6B PDE6G RHO SAG SLC24A1 +Activation of the pre-replicative complex Reactome Pathway CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 RPA1 RPA2 RPA3 RPA4 +Activation, myristolyation of BID and translocation to mitochondria Reactome Pathway BID CASP8 GZMB NMT1 +Activation, translocation and oligomerization of BAX Reactome Pathway BAX BID +Acyl chain remodeling of CL Reactome Pathway HADHA HADHB LCLAT1 PLA2G4A PLA2G6 TAZ +Acyl chain remodeling of DAG and TAG Reactome Pathway DGAT1 DGAT2 MGLL PNPLA2 PNPLA3 +Acyl chain remodelling of PC Reactome Pathway LPCAT1 LPCAT2 LPCAT3 LPCAT4 MBOAT2 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLB1 PLBD1 PNPLA8 +Acyl chain remodelling of PE Reactome Pathway LPCAT3 LPCAT4 MBOAT1 MBOAT2 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLBD1 PNPLA8 +Acyl chain remodelling of PG Reactome Pathway CRLS1 LPCAT1 LPCAT4 LPGAT1 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4D PLA2G4F PLA2G5 +Acyl chain remodelling of PI Reactome Pathway MBOAT7 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLBD1 +Acyl chain remodelling of PS Reactome Pathway LPCAT3 LPCAT4 MBOAT1 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4B PLA2G4D PLA2G4E PLA2G4F PLA2G5 +Adaptive Immune System Reactome Pathway ACTR1A ACTR1B AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AMICA1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ARIH2 ASB1 ASB10 ASB11 ASB12 ASB13 ASB14 ASB15 ASB16 ASB17 ASB18 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 B2M BAD BCL10 BLK BLMH BLNK BTC BTK BTLA BTRC C3 CALM1 CALR CANX CARD11 CASP9 CBL CBLB CD160 CD19 CD200 CD200R1 CD207 CD226 CD247 CD274 CD28 CD34 CD36 CD3D CD3E CD3G CD4 CD40 CD40LG CD74 CD79A CD79B CD80 CD81 CD86 CD8A CD8B CD96 CDC16 CDC20 CDC23 CDC26 CDC27 CDC34 CDC42 CDH1 CDKN1A CDKN1B CENPE CHUK CLTA CLTC CREB1 CRTAM CSK CTLA4 CTSA CTSB CTSC CTSD CTSE CTSF CTSH CTSK CTSL CTSO CTSS CTSV CUL1 CUL2 CUL3 CUL5 CUL7 CXADR CYBA CYBB DAPP1 DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DET1 DNM1 DNM2 DNM3 DTX3L DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DZIP3 EGF EGFR ENAH ERAP1 ERAP2 ERBB2 ERBB3 ERBB4 EREG EVL FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCGR1A FCGR1B FCGR2B FCGR3A FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYB FYN FZR1 GAB1 GAN GLYCAM1 GRAP2 GRB2 GSK3A GSK3B HBEGF HCST HECTD3 HERC2 HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G HRAS HSPA5 HUWE1 ICAM1 ICAM2 ICAM3 ICAM4 ICOS ICOSLG IFI30 IFITM1 IGHD IGHM IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IKBKB IKBKG INPP5D IRS1 IRS2 ITCH ITGA4 ITGAL ITGAV ITGB1 ITGB2 ITGB5 ITGB7 ITK ITPR1 ITPR2 ITPR3 KEAP1 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIFAP3 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR3DL1 KIR3DL2 KIT KITLG KL KLB KLC1 KLC2 KLC3 KLC4 KLHL13 KLHL20 KLHL21 KLHL9 KLRC1 KLRD1 KLRG1 KLRK1 KRAS LAT LCK LCP2 LGMN LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LNPEP LRR1 LRRC41 LRSAM1 LYN MADCAM1 MALT1 MAP3K14 MAP3K7 MAP3K8 MAPKAP1 MDM2 MGRN1 MICA MICB MIR26A1 MIR26A2 MKRN1 MLST8 MOV10 MRC1 MRC2 MTOR NCF1 NCF2 NCF4 NCK1 NEDD4 NEDD4L NFKB1 NFKBIA NFKBIB NFKBIE NPEPPS NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 ORAI1 OSBPL1A PAG1 PAK1 PAK2 PAK3 PARK2 PDCD1 PDCD1LG2 PDGFA PDGFB PDGFRA PDGFRB PDIA3 PDPK1 PHLPP1 PHLPP2 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PJA1 PJA2 PLCG1 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKACA PRKACB PRKACG PRKCB PRKCQ PRKG1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PTPN11 PTPN6 PTPRC PVR PVRL2 RAB7A RAC1 RACGAP1 RAET1E RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RASGRP3 RBCK1 RBX1 RCHY1 REL RELA RICTOR RILP RIPK2 RNF111 RNF123 RNF138 RNF144B RNF182 RNF19B RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS6KB2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SELL SH3GL2 SH3KBP1 SHC1 SIPA1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SOS1 SPSB1 SPSB2 SPSB4 SPTBN2 SRC SRMS STIM1 STUB1 SYK TAB2 TAP1 TAP2 TAPBP TCEB1 TCEB2 TCRA TCRB THEM4 TNFRSF14 TNRC6A TNRC6B TNRC6C TPP2 TRAC TRAF6 TRAT1 TRBC1 TRBV12-3 TRIB3 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 TRPC1 TSC2 TYROBP UBA1 UBA3 UBA5 UBA52 UBA6 UBA7 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 ULBP1 ULBP3 VASP VAV1 VCAM1 VHL VPRBP WAS WSB1 WWP1 YES1 YWHAB YWHAZ ZAP70 ZBTB16 cd21 +Adenosine P1 receptors Reactome Pathway ADORA1 ADORA2A ADORA2B ADORA3 +Adenylate cyclase activating pathway Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAL +Adenylate cyclase inhibitory pathway Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAI1 GNAI2 GNAI3 GNAL GNAT3 +Adherens junctions interactions Reactome Pathway CADM1 CADM2 CADM3 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CTNNA1 CTNNB1 CTNND1 JUP MLLT4 PVR PVRL1 PVRL2 PVRL3 PVRL4 +Adrenaline signalling through Alpha-2 adrenergic receptor Reactome Pathway ADRA2A ADRA2B ADRA2C +Adrenaline,noradrenaline inhibits insulin secretion Reactome Pathway ADCY5 ADCY6 ADRA2A ADRA2C CACNA1C CACNA1D CACNA2D2 CACNB2 CACNB3 GNAI1 GNAI2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 +Adrenoceptors Reactome Pathway ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 +Advanced glycosylation endproduct receptor signaling Reactome Pathway AGER APP CAPZA1 CAPZA2 DDOST HMGB1 LGALS3 MAPK1 MAPK3 PRKCSH S100A12 S100B SAA1 +Aflatoxin activation and detoxification Reactome Pathway ACY1 ACY3 AKR7A2 AKR7A3 AKR7L CYP1A2 CYP2A13 CYP3A4 CYP3A5 DPEP1 DPEP2 DPEP3 GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 MGST1 MGST2 MGST3 +Agmatine biosynthesis Reactome Pathway AGMAT AZIN2 +Alpha-defensins Reactome Pathway ART1 CD4 DEFA1 DEFA3 DEFA4 DEFA5 DEFA6 PRSS2 PRSS3 env +Alpha-oxidation of phytanate Reactome Pathway HACL1 PHYH SLC25A17 SLC27A2 +Alternative complement activation Reactome Pathway C3 CFB CFD GZMM +Amine Oxidase reactions Reactome Pathway MAOA MAOB PAOX SMOX +Amine compound SLC transporters Reactome Pathway RHAG RHBG RHCG SLC14A1 SLC14A2 SLC18A1 SLC18A2 SLC22A1 SLC22A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +Amine ligand-binding receptors Reactome Pathway ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 DRD1 DRD2 DRD3 DRD4 DRD5 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 +Amine-derived hormones Reactome Pathway AANAT ASMT CGA DBH DDC DIO1 DIO2 DIO3 IYD PNMT SLC5A5 TH TPH1 TPH2 TPO TSHB +Amino Acid conjugation Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 GLYAT GLYATL1 GLYATL2 +Amino acid and oligopeptide SLC transporters Reactome Pathway SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A10 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC25A10 SLC32A1 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC5A5 SLC5A8 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 +Amino acid synthesis and interconversion (transamination) Reactome Pathway ALDH18A1 ASNS CCBL1 GLS GLS2 GLUD1 GLUL GOT1 GOT2 GPT GPT2 OAT PHGDH PSAT1 PSPH PYCR1 +Amino acid transport across the plasma membrane Reactome Pathway SLC16A10 SLC1A4 SLC1A5 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 +Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Reactome Pathway MAD1L1 MAD2L1 +Amplification of signal from the kinetochores Reactome Pathway MAD1L1 MAD2L1 +Amyloids Reactome Pathway APCS APOA1 APOA4 APP B2M CALCA CST3 FGA GSN H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HSPG2 IAPP INS ITM2B LTF LYZ MFGE8 NPPA ODAM PRL SAA1 SEMG1 SNCA TGFBI TTR +Anchoring fibril formation Reactome Pathway BMP1 COL7A1 LAMA3 LAMB3 LAMC2 TLL1 TLL2 +Anchoring of the basal body to the plasma membrane Reactome Pathway ACTR1A AKAP9 ALMS1 B9D1 B9D2 C2CD3 CC2D2A CCP110 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP162 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CEP83 CEP89 CEP97 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FBF1 FGFR1OP HAUS2 HSP90AA1 IQCB1 KIF24 MAPRE1 MARK4 MKS1 NDE1 NEDD1 NEK2 NINL NPHP1 NPHP4 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B RAB11A RAB3IP RAB8A RPGRIP1L SCLT1 SDCCAG8 SEPT2 SFI1 SSNA1 TCTN1 TCTN2 TCTN3 TMEM216 TMEM67 TTBK2 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG +Androgen biosynthesis Reactome Pathway CGA CYP17A1 HSD17B12 HSD17B3 HSD3B1 HSD3B2 LHB POMC SRD5A1 SRD5A2 SRD5A3 +Antagonism of Activin by Follistatin Reactome Pathway FST FSTL3 INHBA INHBB +Antigen Presentation: Folding, assembly and peptide loading of class I MHC Reactome Pathway B2M CALR CANX ERAP1 ERAP2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HSPA5 PDIA3 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A TAP1 TAP2 TAPBP +Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Reactome Pathway BLK BLNK BTK CALM1 CBL CBLB CD19 CD79A CD79B DAPP1 FYN GRB2 IGHD IGHM IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV ITPR1 ITPR2 ITPR3 LYN NCK1 ORAI1 PIK3AP1 PIK3CD PIK3R1 PLCG1 PLCG2 SH3KBP1 SHC1 SOS1 SRMS STIM1 SYK TRPC1 VAV1 +Antigen processing-Cross presentation Reactome Pathway B2M CALR CD207 CD36 CTSL CTSS CTSV CYBA CYBB FCGR1A FCGR1B HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G ITGAV ITGB5 LNPEP MRC1 MRC2 NCF1 NCF2 NCF4 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SEC61A1 SEC61A2 SEC61B SEC61G TAP1 TAP2 TAPBP UBA52 UBB UBC +Antigen processing: Ubiquitination & Proteasome degradation Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ARIH2 ASB1 ASB10 ASB11 ASB12 ASB13 ASB14 ASB15 ASB16 ASB17 ASB18 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 BLMH BTRC CBLB CDC16 CDC20 CDC23 CDC26 CDC27 CDC34 CUL1 CUL2 CUL3 CUL5 CUL7 DET1 DTX3L DZIP3 FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FZR1 GAN HECTD3 HERC2 HUWE1 ITCH KEAP1 KLHL13 KLHL20 KLHL21 KLHL9 LNPEP LRR1 LRRC41 LRSAM1 MGRN1 MKRN1 NEDD4 NEDD4L NPEPPS PARK2 PJA1 PJA2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBCK1 RBX1 RCHY1 RNF111 RNF123 RNF138 RNF144B RNF182 RNF19B RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SPSB1 SPSB2 SPSB4 STUB1 TCEB1 TCEB2 TPP2 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 UBA1 UBA3 UBA5 UBA52 UBA6 UBA7 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 VHL VPRBP WSB1 WWP1 ZBTB16 +Antiviral mechanism by IFN-stimulated genes Reactome Pathway AAAS ARIH1 DDX58 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FLNB HERC5 IFIT1 IRF3 ISG15 JAK1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 MAPK3 MX1 MX2 NEDD4 NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PIN1 PLCG1 POM121 PPM1B RAE1 RANBP2 RPS27A SEH1L STAT1 TPR TRIM25 UBA52 UBA7 UBB UBC UBE2E1 UBE2L6 UBE2N USP18 USP41 gag +Apoptosis Reactome Pathway ACIN1 ADD1 AKT1 AKT2 AKT3 APAF1 APC ARHGAP10 BAD BAK1 BAX BBC3 BCAP31 BCL2 BCL2L1 BCL2L11 BID BIRC2 BMF BMX CASP3 CASP6 CASP7 CASP8 CASP9 CDH1 CFLAR CLSPN CTNNB1 CYCS DBNL DFFA DFFB DIABLO DNM1L DSG1 DSG2 DSG3 DSP DYNLL1 DYNLL2 E2F1 FADD FAS FASLG FNTA GAS2 GSN GZMB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 LMNA LMNB1 MAPK8 MAPT MC159L MST4 NMT1 OCLN ORF71 PAK2 PKP1 PLEC PMAIP1 PPP3CC PPP3R1 PRKCD PRKCQ PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTK2 RIPK1 ROCK1 RPS27A SATB1 SFN SPTAN1 STK24 TFDP1 TJP1 TJP2 TNFRSF10A TNFRSF10B TNFSF10 TP53 TRADD TRAF2 UBA52 UBB UBC VIM XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Apoptosis induced DNA fragmentation Reactome Pathway CASP3 DFFA DFFB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 +Apoptotic cleavage of cell adhesion proteins Reactome Pathway CASP3 CDH1 CTNNB1 DSG1 DSG2 DSG3 DSP OCLN PKP1 TJP1 TJP2 +Apoptotic cleavage of cellular proteins Reactome Pathway ACIN1 ADD1 APC BCAP31 BIRC2 BMX CASP3 CASP6 CASP7 CASP8 CDH1 CLSPN CTNNB1 DBNL DSG1 DSG2 DSG3 DSP FNTA GAS2 GSN LMNA LMNB1 MAPT MST4 OCLN PKP1 PLEC PRKCD PRKCQ PTK2 ROCK1 SATB1 SPTAN1 STK24 TJP1 TJP2 VIM +Apoptotic execution phase Reactome Pathway ACIN1 ADD1 APC BCAP31 BIRC2 BMX CASP3 CASP6 CASP7 CASP8 CDH1 CLSPN CTNNB1 DBNL DFFA DFFB DNM1L DSG1 DSG2 DSG3 DSP FNTA GAS2 GSN H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 LMNA LMNB1 MAPT MST4 OCLN PAK2 PKP1 PLEC PRKCD PRKCQ PTK2 ROCK1 SATB1 SPTAN1 STK24 TJP1 TJP2 VIM +Apoptotic factor-mediated response Reactome Pathway APAF1 CASP3 CASP7 CASP9 CYCS DIABLO XIAP +Aquaporin-mediated transport Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP10 AQP11 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MIP MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 +Arachidonate production from DAG Reactome Pathway DAGLA DAGLB MGLL +Arachidonic acid metabolism Reactome Pathway ABCC1 AKR1C3 ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 ALOX5AP CBR1 CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP2U1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP8B1 DPEP1 DPEP2 DPEP3 EPHX2 FAM213B GGT1 GGT5 GPX1 GPX2 GPX4 HPGD HPGDS LTA4H LTC4S MAPKAPK2 PLA2G4A PTGDS PTGES PTGES3 PTGIS PTGR1 PTGS1 PTGS2 TBXAS1 +Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Reactome Pathway CYP1A2 +Asparagine N-linked glycosylation Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Assembly Of The HIV Virion Reactome Pathway FURIN NMT2 PPIA RPS27A TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D env gag gag-pol nef rev vif vpr vpu +Assembly of Viral Components at the Budding Site Reactome Pathway CALR CANX HA M NA NP +Assembly of collagen fibrils and other multimeric structures Reactome Pathway BMP1 CD151 COL10A1 COL11A1 COL11A2 COL15A1 COL18A1 COL1A1 COL1A2 COL24A1 COL27A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 CTSB CTSL CTSS CTSV DST ITGA6 ITGB4 LAMA3 LAMB3 LAMC2 LOX LOXL1 LOXL2 LOXL3 LOXL4 MMP13 MMP20 MMP3 MMP7 MMP9 PCOLCE PLEC TLL1 TLL2 +Assembly of the ORC complex at the origin of replication Reactome Pathway ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Reactome Pathway H2AFX MRE11A NBN RAD50 +Assembly of the RAD51-ssDNA nucleoprotein complex Reactome Pathway RAD51 RAD52 RPA1 RPA2 RPA3 +Assembly of the pre-replicative complex Reactome Pathway CDC6 CDT1 E2F1 E2F2 E2F3 GMNN MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Assembly of the primary cilium Reactome Pathway ACTR1A AKAP9 ALMS1 ARF4 ARL13B ARL3 ARL6 ASAP1 ATAT1 B9D1 B9D2 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 C2CD3 CC2D2A CCP110 CCT2 CCT3 CCT4 CCT5 CCT8 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP162 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CEP83 CEP89 CEP97 CETN2 CKAP5 CLASP1 CLUAP1 CNGA2 CNGA4 CNGB1 CNTRL CSNK1D CSNK1E CYS1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 FBF1 FGFR1OP GBF1 HAUS2 HDAC6 HSP90AA1 HSPB11 IFT122 IFT140 IFT172 IFT20 IFT22 IFT27 IFT43 IFT46 IFT52 IFT57 IFT74 IFT80 IFT81 IFT88 INPP5E IQCB1 KIF17 KIF24 KIF3A KIF3B KIF3C KIFAP3 LZTFL1 MAPRE1 MARK4 MCHR1 MKKS MKS1 NDE1 NEDD1 NEK2 NINL NPHP1 NPHP3 NPHP4 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PDE6D PKD1 PKD2 PLK1 PLK4 PPP2R1A PRKACA PRKAR2B RAB11A RAB11FIP3 RAB3IP RAB8A RHO RP2 RPGRIP1L SCLT1 SDCCAG8 SEPT2 SFI1 SMO SSNA1 SSTR3 TCP1 TCTE3 TCTEX1D1 TCTEX1D2 TCTN1 TCTN2 TCTN3 TMEM216 TMEM67 TNPO1 TRAF3IP1 TRIP11 TTBK2 TTC21B TTC26 TTC30A TTC30B TTC8 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 UNC119B WDR19 WDR34 WDR35 WDR60 YWHAE YWHAG +Association of TriC/CCT with target proteins during biosynthesis Reactome Pathway AP3M1 ARFGEF2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 KIF13A KIFC3 LONP2 NOP56 SKIV2L SPHK1 TCP1 USP11 XRN2 +Association of licensing factors with the pre-replicative complex Reactome Pathway CDC6 CDT1 E2F1 E2F2 E2F3 GMNN ORC1 ORC2 ORC3 ORC4 ORC5 RPS27A UBA52 UBB UBC +Astrocytic Glutamate-Glutamine Uptake And Metabolism Reactome Pathway GLUL SLC1A2 SLC1A3 SLC38A1 +Asymmetric localization of PCP proteins Reactome Pathway DVL2 FZD1 FZD2 FZD3 FZD4 FZD5 FZD7 FZD8 PARD6A PRICKLE1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SCRIB SMURF1 SMURF2 UBA52 UBB UBC VANGL2 WNT5A +Attachment of GPI anchor to uPAR Reactome Pathway GPAA1 PGAP1 PIGK PIGS PIGT PIGU PLAUR +Attenuation phase Reactome Pathway COL4A6 CREBBP CRYBA4 DEDD2 DNAJB1 DNAJB6 EP300 FKBP4 GML HSBP1 HSBP2 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPH1 MRPL18 PTGES3 RLN1 SERPINH1 TNFRSF21 UBB +Autodegradation of Cdh1 by Cdh1:APC/C Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC23 CDC26 CDC27 FZR1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Autodegradation of the E3 ubiquitin ligase COP1 Reactome Pathway ATM PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RPS27A TP53 UBA52 UBB UBC +Autointegration results in viral DNA circles Reactome Pathway BANF1 HMGA1 PSIP1 gag gag-pol rev vif vpr vpu +Axon guidance Reactome Pathway ABL1 ABL2 ABLIM1 ABLIM2 ABLIM3 ACTB ACTG1 ACTR2 ACTR3 ADAM10 AGAP2 AGRN ALCAM ANK1 ANK2 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGAP35 ARHGAP39 ARHGEF11 ARHGEF12 ARHGEF28 ARHGEF7 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ARTN CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CAP1 CAP2 CD24 CD72 CDC42 CDK1 CDK5 CDK5R1 CFL1 CHL1 CLASP1 CLASP2 CLTA CLTB CLTC CLTCL1 CNTN1 CNTN2 CNTN6 CNTNAP1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CREB1 CRMP1 CSNK2A1 CSNK2A2 CSNK2B DCC DCX DLG1 DLG3 DLG4 DNM1 DNM2 DNM3 DOCK1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EGFR ENAH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 ERBB2 EVL EZR FARP2 FES FGFR1 FYN GDNF GFRA1 GFRA2 GFRA4 GIT1 GPC1 GRB2 GRIN1 GRIN2B GSK3B HFE2 HRAS HSP90AA1 HSP90AB1 HSPA8 IL6 IL6R IL6ST ITGA1 ITGA10 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 ITSN1 JAK1 JAK2 KALRN KCNQ2 KCNQ3 KDR KIAA1598 KIF4A KIF4B KRAS L1CAM LAMA1 LAMB1 LAMC1 LIMK1 LIMK2 LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MET MMP2 MMP9 MSN MYH10 MYH11 MYH14 MYH9 MYL12A MYL12B MYL6 MYL9 MYO10 NCAM1 NCAN NCK1 NCK2 NCSTN NEO1 NFASC NGEF NRAS NRCAM NRP1 NRP2 NRTN NTN1 NTN4 NUMB PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PFN1 PFN2 PIP5K1C PITPNA PLCG1 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB3 PLXNC1 PLXND1 PRKCQ PRNP PSEN2 PSENEN PSPN PTK2 PTPN11 PTPRA PTPRC RAC1 RAC2 RAF1 RANBP9 RASA1 RDX RGMA RGMB RHOA RHOB RHOC RHOG RND1 ROBO1 ROBO2 ROBO3 ROCK1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SDC2 SDCBP SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A SH3GL2 SHB SIAH1 SIAH2 SLIT1 SLIT2 SLIT3 SOS1 SOS2 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC SRGAP1 SRGAP2 SRGAP3 ST8SIA2 ST8SIA4 TIAM1 TLN1 TREM2 TRIO TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TYK2 TYROBP UNC5A UNC5B UNC5C UNC5D VASP VAV2 VAV3 VEGFA WASL YES1 YWHAB +Axonal growth inhibition (RHOA activation) Reactome Pathway ARHGDIA ARHGEF1 LINGO1 MAG NGFR OMG RHOA RTN4 +Axonal growth stimulation Reactome Pathway ARHGDIA NGF NGFR RHOA +BBSome-mediated cargo-targeting to cilium Reactome Pathway ARL6 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 CCT2 CCT3 CCT4 CCT5 CCT8 LZTFL1 MCHR1 MKKS RAB3IP SMO SSTR3 TCP1 TTC8 +BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Reactome Pathway BAD BBC3 BCL2 BCL2L1 BCL2L11 BID BMF PMAIP1 +BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome Pathway ARNTL ARNTL2 AVP BHLHE40 BHLHE41 CARM1 CCRN4L CHD9 CLOCK CREBBP CRY1 CRY2 DBP EP300 F7 HDAC3 HELZ2 MED1 NAMPT NCOA1 NCOA2 NCOA6 NCOR1 NPAS2 NR1D1 NR3C1 PER1 PER2 PPARA PPARGC1A RORA RXRA SERPINE1 SMARCD3 TBL1X TBL1XR1 TGS1 +Base Excision Repair Reactome Pathway APEX1 CCNO FEN1 LIG1 LIG3 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG UNG XRCC1 +Base-Excision Repair, AP Site Formation Reactome Pathway CCNO MBD4 MPG MUTYH NTHL1 OGG1 SMUG1 TDG UNG +Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Reactome Pathway APEX1 CCNO MBD4 MPG MUTYH NTHL1 OGG1 POLB SMUG1 TDG UNG +Basigin interactions Reactome Pathway ATP1B1 ATP1B2 ATP1B3 BSG CAV1 ITGA3 ITGA6 ITGB1 L1CAM MAG MMP1 PPIA PPIL2 SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SPN +Beta defensins Reactome Pathway CCR2 CCR6 DEFB1 DEFB103A DEFB104A DEFB105A DEFB106A DEFB107A DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB4A TLR1 TLR2 +Beta oxidation of butanoyl-CoA to acetyl-CoA Reactome Pathway ACADS ECHS1 HADH +Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Reactome Pathway ACADM ECHS1 HADH HADHA HADHB +Beta oxidation of hexanoyl-CoA to butanoyl-CoA Reactome Pathway ACADS ECHS1 HADH HADHA HADHB +Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Reactome Pathway ACADL ECHS1 HADH HADHA HADHB +Beta oxidation of myristoyl-CoA to lauroyl-CoA Reactome Pathway ACADL HADHA HADHB +Beta oxidation of octanoyl-CoA to hexanoyl-CoA Reactome Pathway ACADM ECHS1 HADH HADHA HADHB +Beta oxidation of palmitoyl-CoA to myristoyl-CoA Reactome Pathway ACADVL HADHA HADHB +Beta-catenin phosphorylation cascade Reactome Pathway AMER1 APC AXIN1 CSNK1A1 CTNNB1 FRAT1 FRAT2 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E +Beta-oxidation of pristanoyl-CoA Reactome Pathway ACOT8 ACOX2 ACOX3 AMACR CRAT CROT HSD17B4 SCP2 +Beta-oxidation of very long chain fatty acids Reactome Pathway ABCD1 ACAA1 ACOT8 ACOX1 CRAT HSD17B4 +Bicarbonate transporters Reactome Pathway SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 +Bile acid and bile salt metabolism Reactome Pathway ABCB11 ABCC3 ACOT8 ACOX2 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 ALB AMACR BAAT CH25H CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 FABP6 HSD17B4 HSD3B7 NCOA1 NCOA2 NR1H4 PTGIS RXRA SCP2 SLC10A1 SLC10A2 SLC27A2 SLC27A5 SLCO1A2 SLCO1B1 SLCO1B3 +Bile salt and organic anion SLC transporters Reactome Pathway SLC10A6 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 SLC16A1 SLC16A3 SLC16A7 SLC16A8 SLC47A1 SLC47A2 +Binding and Uptake of Ligands by Scavenger Receptors Reactome Pathway ALB AMBP APOA1 APOB APOE APOL1 CALR CD163 CD36 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COLEC11 COLEC12 FTH1 FTL HBA1 HBB HP HPR HPX HSP90AA1 HSP90B1 HSPH1 HYOU1 IGHA1 IGHA2 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 LRP1 MARCO MASP1 MSR1 SAA1 SCARA5 SCARB1 SCARF1 SCGB3A2 SPARC STAB1 STAB2 porB +Binding and entry of HIV virion Reactome Pathway CCR5 CD4 CXCR4 PPIA env gag gag-pol nef rev vif vpr vpu +Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Reactome Pathway MAOA MAOB +Biological oxidations Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 ACSS1 ACSS2 ACY1 ACY3 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 AHCY AKR7A2 AKR7A3 AKR7L ALDH1A1 ALDH2 BPNT1 CNDP2 COMT CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 DPEP1 DPEP2 DPEP3 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAOA MAOB MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NCOA1 NCOA2 NNMT NR1H4 OPLAH PAOX PAPSS1 PAPSS2 POMC PTGIS PTGS1 RXRA SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SMOX SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TBXAS1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Biosynthesis of A2E, implicated in retinal degradation Reactome Pathway NAPEPLD +Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 CMAS CTSA DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PGM3 PMM1 PMM2 RFT1 SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 UAP1 +Biotin transport and metabolism Reactome Pathway ACACA ACACB BTD HLCS MCCC1 MCCC2 PC PCCA PCCB PDZD11 SLC5A6 +Branched-chain amino acid catabolism Reactome Pathway ACAD8 ACADSB ACAT1 ALDH6A1 AUH BCAT1 BCAT2 BCKDHA BCKDHB DBT DLD HIBADH HIBCH HSD17B10 IVD MCCC1 MCCC2 +Breakdown of the nuclear lamina Reactome Pathway CASP6 LMNA LMNB1 +Budding Reactome Pathway HA M NA NP NS PA PB1 PB2 +Budding and maturation of HIV virion Reactome Pathway CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 NEDD4L PDCD6IP PPIA RPS27A TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 env gag gag-pol nef rev vif vpr vpu +Butyrate Response Factor 1 (BRF1) destabilizes mRNA Reactome Pathway AKT1 DCP1A DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MAPKAPK2 XRN1 YWHAB ZFP36L1 +C6 deamination of adenosine Reactome Pathway ADAR ADARB1 +CD28 co-stimulation Reactome Pathway AKT1 AKT2 AKT3 CD28 CD80 CD86 CDC42 FYN GRAP2 GRB2 LCK LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 RAC1 RICTOR SRC THEM4 TRIB3 VAV1 YES1 +CD28 dependent PI3K/Akt signaling Reactome Pathway AKT1 AKT2 AKT3 CD28 CD80 CD86 FYN LCK MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 RICTOR THEM4 TRIB3 +CD28 dependent Vav1 pathway Reactome Pathway CD28 CD80 CD86 CDC42 FYN GRB2 LCK PAK1 PAK2 PAK3 RAC1 VAV1 +CDC6 association with the ORC:origin complex Reactome Pathway CDC6 E2F1 E2F2 E2F3 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +CDK-mediated phosphorylation and removal of Cdc6 Reactome Pathway CDC6 CDK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +CDO in myogenesis Reactome Pathway ABL1 BNIP2 BOC CDC42 CDH15 CDH2 CDH4 CDON CTNNA1 CTNNA2 CTNNB1 MAP2K6 MAPK11 MAPK12 MAPK14 MEF2A MEF2B MEF2C MEF2D MYF5 MYF6 MYOD1 MYOG NEO1 NTN3 SPAG9 TCF12 TCF3 TCF4 +CDT1 association with the CDC6:ORC:origin complex Reactome Pathway CDC6 CDT1 GMNN MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +CHL1 interactions Reactome Pathway ANK1 CHL1 CNTN6 HSPA8 ITGA1 ITGA10 ITGA2 ITGB1 NRP1 +COPI Mediated Transport Reactome Pathway ARCN1 ARF1 ARFGAP1 COPA COPB1 COPB2 COPE COPG1 COPZ1 GBF1 +COPII (Coat Protein 2) Mediated Vesicle Transport Reactome Pathway PREB SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A +COX reactions Reactome Pathway PTGS1 +CREB phosphorylation Reactome Pathway ATF1 CREB1 MAPKAPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +CREB phosphorylation through the activation of Adenylate Cyclase Reactome Pathway ADCY1 ADCY3 ADCY8 CREB1 PRKACA PRKACB PRKACG +CREB phosphorylation through the activation of CaMKII Reactome Pathway ACTN2 AKAP9 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CREB1 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL +CREB phosphorylation through the activation of CaMKK Reactome Pathway CALM1 CAMK4 CAMKK1 CREB1 +CREB phosphorylation through the activation of Ras Reactome Pathway ACTN2 AKAP9 BRAF CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CREB1 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +CRMPs in Sema3A signaling Reactome Pathway CDK5 CDK5R1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 FES FYN GSK3B NRP1 PLXNA1 PLXNA2 PLXNA3 PLXNA4 SEMA3A +CS/DS degradation Reactome Pathway ARSB BCAN BGN CSPG4 CSPG5 DCN HEXA HEXB HYAL1 HYAL3 IDS IDUA NCAN VCAN +CTLA4 inhibitory signaling Reactome Pathway AKT1 AKT2 AKT3 CD80 CD86 CTLA4 FYN LCK LYN PDPK1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 SRC YES1 +CYP2E1 reactions Reactome Pathway CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2S1 +Ca-dependent events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 MAPK1 PDE1A PDE1B PDE1C PLA2G4A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +Ca2+ activated K+ channels Reactome Pathway KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3 KCNN4 +Ca2+ pathway Reactome Pathway AGO1 AGO2 AGO3 AGO4 AXIN2 CALM1 CAMK2A CTNNB1 FZD2 FZD3 FZD4 FZD5 FZD6 GNAO1 GNAT2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR1 ITPR2 ITPR3 LEF1 MAP3K7 MIR92b MOV10 NFATC1 NLK PDE6A PDE6B PDE6G PLCB1 PLCB2 PLCB3 PPP3CA PPP3CB PPP3R1 PRKCA PRKG1 PRKG2 TCF7 TCF7L1 TCF7L2 TNRC6A TNRC6B TNRC6C WNT11 WNT5A +CaM pathway Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +CaMK IV-mediated phosphorylation of CREB Reactome Pathway CALM1 CAMK4 CREB1 +Calcitonin-like ligand receptors Reactome Pathway ADM ADM2 CALCA CALCB CALCR CALCRL IAPP RAMP1 RAMP2 RAMP3 +Calmodulin induced events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +Calnexin/calreticulin cycle Reactome Pathway CALR CANX EDEM1 EDEM2 EDEM3 GANAB MAN1B1 PDIA3 PRKCSH UGGT1 UGGT2 +Cam-PDE 1 activation Reactome Pathway CALM1 PDE1A PDE1B PDE1C +Cap-dependent Translation Initiation Reactome Pathway EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5B FAU PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Cargo trafficking to the periciliary membrane Reactome Pathway ARF4 ARL13B ARL3 ARL6 ASAP1 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 CCT2 CCT3 CCT4 CCT5 CCT8 CNGA2 CNGA4 CNGB1 CYS1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 INPP5E LZTFL1 MCHR1 MKKS NPHP3 PDE6D PKD1 PKD2 RAB11A RAB11FIP3 RAB3IP RAB8A RHO RP2 SMO SSTR3 TCP1 TTC8 UNC119B +Carnitine synthesis Reactome Pathway ALDH9A1 BBOX1 SHMT1 TMLHE +Caspase-8 activation by cleavage Reactome Pathway CASP8 CFLAR FADD FAS FASLG MC159L ORF71 RIPK1 TNFRSF10A TNFRSF10B TNFSF10 TRADD TRAF2 +Caspase-mediated cleavage of cytoskeletal proteins Reactome Pathway ADD1 CASP3 CASP6 CASP7 CASP8 DBNL GAS2 GSN MAPT PLEC SPTAN1 VIM +Catecholamine biosynthesis Reactome Pathway DBH DDC PNMT TH +Cation-coupled Chloride cotransporters Reactome Pathway SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 +Cdc20:Phospho-APC/C mediated degradation of Cyclin A Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Cell Cycle Reactome Pathway AAAS ACD ACTR1A AHCTF1 AJUBA AKAP9 ALMS1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANKLE2 APEX1 APITD1 ARPP19 ATM ATR ATRIP AURKA AURKB B9D2 BANF1 BIRC5 BLM BLZF1 BORA BRCA1 BRCA2 BTRC BUB1 BUB1B BUB3 CASC5 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CCP110 CDC14A CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC27 CDC45 CDC6 CDC7 CDCA5 CDCA8 CDK1 CDK11A CDK11B CDK2 CDK4 CDK5RAP2 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CENPA CENPC CENPE CENPF CENPH CENPI CENPJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CENPW CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CHEK1 CHEK2 CKAP5 CKS1B CLASP1 CLASP2 CLIP1 CLSPN CNEP1R1 CNTRL CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B CTDNEP1 CUL1 DBF4 DCTN1 DCTN2 DCTN3 DHFR DIDO1 DKC1 DMC1 DNA2 DSN1 DYNC1H1 DYNC1I2 DYNLL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 EMD ENSA EP300 ERCC6L ESCO1 ESCO2 ESPL1 FBXO5 FBXW11 FEN1 FGFR1OP FKBP6 FOXM1 FZR1 GINS1 GINS2 GINS4 GMNN GOLGA2 GORASP1 GORASP2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HAUS2 HDAC1 HDAC8 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HJURP HSP90AA1 HSPA2 HUS1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LEMD2 LEMD3 LIG1 LIN37 LIN52 LIN54 LIN9 LMNA LMNB1 LPIN1 LPIN2 LPIN3 MAD1L1 MAD2L1 MAPK1 MAPK3 MAPRE1 MASTL MAU2 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MCPH1 MDM2 MIS12 MIS18A MIS18BP1 MLH1 MLH3 MNAT1 MND1 MRE11A MSH4 MSH5 MYBL2 MYC NBN NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 NDC80 NDE1 NDEL1 NEDD1 NEK2 NEK6 NEK7 NEK9 NHP2 NINL NIPBL NPM1 NSL1 NUDC NUF2 NUMA1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 ODF2 OFD1 OIP5 OPTN ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PCM1 PCNA PCNT PDS5A PDS5B PHF8 PKMYT1 PLK1 PLK4 PMF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POM121 POT1 PPP1CB PPP1CC PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2D PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM9 PRIM1 PRIM2 PRKACA PRKAR2B PRKCA PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC3IP PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAB1A RAB1B RAB2A RAB8A RAD1 RAD17 RAD21 RAD50 RAD51 RAD51C RAD9A RAD9B RAE1 RANBP2 RANGAP1 RB1 RBBP4 RBBP7 RBBP8 RBL1 RBL2 RCC2 REC8 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD2 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RRM2 RSF1 RUVBL1 RUVBL2 SDCCAG8 SEC13 SEH1L SET SETD8 SFI1 SGOL1 SGOL2 SKA1 SKA2 SKP1 SKP2 SMARCA5 SMC1A SMC1B SMC2 SMC3 SMC4 SPC24 SPC25 SPDL1 SPO11 SSNA1 STAG1 STAG2 STAG3 STRA13 SUN1 SUN2 SYCE1 SYCE2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TAOK1 TERF1 TERF2 TERF2IP TERT TEX12 TEX15 TFDP1 TFDP2 TINF2 TK2 TMPO TOP2A TOP3A TP53 TPR TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TYMS UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2I USO1 VRK1 VRK2 WAPAL WEE1 WRAP53 XPO1 YWHAE YWHAG ZW10 ZWILCH ZWINT +Cell Cycle Checkpoints Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ATM ATR ATRIP BUB1B BUB3 CCNB1 CCNB2 CCNE1 CCNE2 CDC16 CDC20 CDC23 CDC25A CDC25C CDC26 CDC27 CDC45 CDC6 CDC7 CDK1 CDK2 CDKN1A CDKN1B CHEK1 CHEK2 CLSPN DBF4 HUS1 MAD1L1 MAD2L1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MDM2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PKMYT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAD1 RAD17 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 RFWD2 RPA1 RPA2 RPA3 RPS27A TP53 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 WEE1 +Cell Cycle, Mitotic Reactome Pathway AAAS ACTR1A AHCTF1 AJUBA AKAP9 ALMS1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANKLE2 APEX1 APITD1 ARPP19 AURKA AURKB B9D2 BANF1 BIRC5 BLZF1 BORA BTRC BUB1 BUB1B BUB3 CASC5 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CCP110 CDC14A CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC27 CDC45 CDC6 CDC7 CDCA5 CDCA8 CDK1 CDK11A CDK11B CDK2 CDK4 CDK5RAP2 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CENPA CENPC CENPE CENPF CENPH CENPI CENPJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CKS1B CLASP1 CLASP2 CLIP1 CNEP1R1 CNTRL CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B CTDNEP1 CUL1 DBF4 DCTN1 DCTN2 DCTN3 DHFR DNA2 DSN1 DYNC1H1 DYNC1I2 DYNLL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 EMD ENSA EP300 ERCC6L ESCO1 ESCO2 ESPL1 FBXO5 FBXW11 FEN1 FGFR1OP FOXM1 FZR1 GINS1 GINS2 GINS4 GMNN GOLGA2 GORASP1 GORASP2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HAUS2 HDAC1 HDAC8 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HSP90AA1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LEMD2 LEMD3 LIG1 LIN37 LIN52 LIN54 LIN9 LMNA LMNB1 LPIN1 LPIN2 LPIN3 MAD1L1 MAD2L1 MAPK1 MAPK3 MAPRE1 MASTL MAU2 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MCPH1 MIS12 MNAT1 MYBL2 MYC NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 NDC80 NDE1 NDEL1 NEDD1 NEK2 NEK6 NEK7 NEK9 NINL NIPBL NSL1 NUDC NUF2 NUMA1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 ODF2 OFD1 OPTN ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PCM1 PCNA PCNT PDS5A PDS5B PHF8 PKMYT1 PLK1 PLK4 PMF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POM121 PPP1CB PPP1CC PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2D PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRIM1 PRIM2 PRKACA PRKAR2B PRKCA PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAB1A RAB1B RAB2A RAB8A RAD21 RAE1 RANBP2 RANGAP1 RB1 RBBP4 RBL1 RBL2 RCC2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RRM2 SDCCAG8 SEC13 SEH1L SET SETD8 SFI1 SGOL1 SGOL2 SKA1 SKA2 SKP1 SKP2 SMC1A SMC2 SMC3 SMC4 SPC24 SPC25 SPDL1 SSNA1 STAG1 STAG2 TAOK1 TFDP1 TFDP2 TK2 TMPO TOP2A TPR TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TYMS UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 USO1 VRK1 VRK2 WAPAL WEE1 XPO1 YWHAE YWHAG ZW10 ZWILCH ZWINT +Cell death signalling via NRAGE, NRIF and NADE Reactome Pathway AATF ABR AKAP13 APH1A APH1B ARHGAP4 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 CASP2 CASP3 ECT2 FGD1 FGD2 FGD3 FGD4 ITGB3BP ITSN1 KALRN MAGED1 MAPK8 MCF2 MCF2L NCSTN NET1 NGEF NGF NGFR NGFRAP1 OBSCN PLEKHG2 PLEKHG5 PSEN2 PSENEN RAC1 RASGRF2 RPS27A SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 UBB UBC VAV1 VAV2 VAV3 YWHAE +Cell junction organization Reactome Pathway ACTN1 ARHGEF6 CADM1 CADM2 CADM3 CD151 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL17A1 CRB3 CTNNA1 CTNNB1 CTNND1 DST F11R FBLIM1 FERMT2 FLNA FLNC ILK INADL ITGA6 ITGB1 ITGB4 JUP LAMA3 LAMB3 LAMC2 LIMS1 LIMS2 MLLT4 MPP5 PARD3 PARD6A PARD6B PARD6G PARVA PARVB PLEC PRKCI PVR PVRL1 PVRL2 PVRL3 PVRL4 PXN RSU1 TESK1 VASP +Cell redox homeostasis Reactome Pathway ahpC ahpD dlaT fgd1 lpdC tpx trx-2 trxA trxB +Cell surface interactions at the vascular wall Reactome Pathway AMICA1 ANGPT1 ANGPT2 ANGPT4 APOB ATP1B1 ATP1B2 ATP1B3 BSG CAV1 CD177 CD2 CD244 CD44 CD47 CD48 CD58 CD84 CEACAM1 CEACAM6 CEACAM8 CXADR DOK2 ESAM F11R F2 FCER1G FN1 FYN GAS6 GLG1 GP6 GRB14 GRB2 GRB7 HRAS INPP5D ITGA3 ITGA4 ITGA5 ITGA6 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 JAM2 JAM3 KRAS L1CAM LCK LYN MAG MERTK MMP1 NRAS OLR1 PECAM1 PF4 PF4V1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPIA PPIL2 PROC PROCR PROS1 PTPN11 PTPN6 SELE SELL SELP SELPLG SHC1 SIRPA SIRPG SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SOS1 SPN SRC TEK THBD TREM1 YES1 +Cell-Cell communication Reactome Pathway ACTN1 ACTN2 ACTN3 ACTN4 ARHGEF6 CADM1 CADM2 CADM3 CASK CD151 CD2AP CD47 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL17A1 CRB3 CTNNA1 CTNNB1 CTNND1 DCC DSCAM DSCAML1 DST F11R FBLIM1 FERMT2 FLNA FLNC FYB FYN GRB2 ILK INADL IQGAP1 ITGA6 ITGB1 ITGB4 JUP KIRREL KIRREL2 KIRREL3 LAMA3 LAMB3 LAMC2 LIMS1 LIMS2 MAGI2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MLLT4 MPP5 NCK1 NCK2 NPHS1 NTN1 PAK1 PARD3 PARD6A PARD6B PARD6G PARVA PARVB PIK3CA PIK3CB PIK3R1 PIK3R2 PLEC PRKCI PTK2 PTK2B PTPN11 PTPN6 PVR PVRL1 PVRL2 PVRL3 PVRL4 PXN RAC1 RSU1 SIRPA SIRPB1 SIRPG SKAP2 SPTAN1 SPTBN1 SRC TESK1 TYROBP VASP WASL +Cell-cell junction organization Reactome Pathway CADM1 CADM2 CADM3 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 CTNNA1 CTNNB1 CTNND1 F11R INADL JUP MLLT4 MPP5 PARD3 PARD6A PARD6B PARD6G PRKCI PVR PVRL1 PVRL2 PVRL3 PVRL4 +Cell-extracellular matrix interactions Reactome Pathway ACTN1 ARHGEF6 FBLIM1 FERMT2 FLNA FLNC ILK ITGB1 LIMS1 LIMS2 PARVA PARVB PXN RSU1 TESK1 VASP +Cellular Senescence Reactome Pathway ACD AGO1 AGO3 AGO4 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ASF1A ATM BMI1 CABIN1 CBX2 CBX4 CBX6 CBX8 CCNA1 CCNA2 CCNE1 CCNE2 CDC16 CDC23 CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CEBPB CXCL8 E2F1 E2F2 E2F3 EED EHMT1 EHMT2 EP400 ERF ETS1 ETS2 EZH2 FOS FZR1 H1F0 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIRA HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HMGA1 HMGA2 ID1 IFNB1 IGFBP7 IL1A IL6 IL8 JUN KDM6B LMNB1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MDM2 MINK1 MIR24-1 MIR24-2 MOV10 MRE11A NBN NFKB1 PHC1 PHC2 PHC3 POT1 RAD50 RB1 RBBP4 RBBP7 RELA RING1 RNF2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 SCMH1 SP1 STAT3 SUZ12 TERF1 TERF2 TERF2IP TFDP1 TINF2 TNIK TNRC6A TNRC6B TNRC6C TP53 TXN UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBN1 +Cellular response to heat stress Reactome Pathway AKT1S1 ATM ATR CAMK2A CAMK2B CAMK2D CAMK2G CCAR2 COL4A6 CREBBP CRYBA4 DEDD2 DNAJB1 DNAJB6 EEF1A1 EP300 FKBP4 GML GSK3B HDAC6 HSBP1 HSBP2 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPH1 MAPK1 MAPK3 MAPKAPK2 MLST8 MRPL18 MTOR PTGES3 RLN1 RPA1 RPA2 RPA3 RPS19BP1 RPTOR SERPINH1 SIRT1 TNFRSF21 UBB VCP YWHAE +Cellular response to hypoxia Reactome Pathway ARNT CA9 CREBBP CUL2 EGLN1 EGLN2 EGLN3 EP300 EPAS1 EPO HIF1A HIF1AN HIF3A RBX1 RPS27A TCEB1 TCEB2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 VEGFA VHL +Cellular responses to stress Reactome Pathway ACD AGO1 AGO3 AGO4 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AQP8 ARNT ASF1A ATM ATOX1 ATP7A ATR BMI1 CA9 CABIN1 CAMK2A CAMK2B CAMK2D CAMK2G CAT CBX2 CBX4 CBX6 CBX8 CCAR2 CCNA1 CCNA2 CCNE1 CCNE2 CCS CDC16 CDC23 CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CEBPB COL4A6 CREBBP CRYBA4 CUL2 CXCL8 CYCS DEDD2 DNAJB1 DNAJB6 E2F1 E2F2 E2F3 EED EEF1A1 EGLN1 EGLN2 EGLN3 EHMT1 EHMT2 EP300 EP400 EPAS1 EPO ERF ERO1L ETS1 ETS2 EZH2 FKBP4 FOS FZR1 GML GPX1 GPX2 GPX3 GPX7 GPX8 GSK3B GSR GSTP1 H1F0 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC6 HIF1A HIF1AN HIF3A HIRA HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HMGA1 HMGA2 HSBP1 HSBP2 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPH1 ID1 IFNB1 IGFBP7 IL1A IL6 IL8 JUN KDM6B LMNB1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MDM2 MINK1 MIR24-1 MIR24-2 MLST8 MOV10 MRE11A MRPL18 MTOR NBN NFKB1 P4HB PHC1 PHC2 PHC3 POT1 PRDX1 PRDX2 PRDX3 PRDX5 PRDX6 PTGES3 RAD50 RB1 RBBP4 RBBP7 RBX1 RELA RING1 RLN1 RNF2 RPA1 RPA2 RPA3 RPS19BP1 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPTOR SCMH1 SERPINH1 SIRT1 SOD1 SOD2 SOD3 SP1 STAT3 SUZ12 TCEB1 TCEB2 TERF1 TERF2 TERF2IP TFDP1 TINF2 TNFRSF21 TNIK TNRC6A TNRC6B TNRC6C TP53 TXN TXN2 TXNRD1 TXNRD2 UBA52 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBN1 VCP VEGFA VHL YWHAE +Centrosome maturation Reactome Pathway ACTR1A AKAP9 ALMS1 CCNB1 CCP110 CDK1 CDK11A CDK11B CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL NUMA1 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 YWHAE YWHAG +Ceramide signalling Reactome Pathway NGF NGFR SMPD2 +ChREBP activates metabolic gene expression Reactome Pathway ACACA ACACB ACLY AGPAT1 FASN MLX MLXIPL PKLR +Chaperonin-mediated protein folding Reactome Pathway ACTB AP3M1 ARFGEF2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 KIF13A KIFC3 LONP2 NOP56 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 SKIV2L SPHK1 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 USP11 VBP1 XRN2 +Chemokine receptors bind chemokines Reactome Pathway ACKR2 ACKR3 ACKR4 CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 PF4 PPBP XCL1 XCL2 XCR1 +Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Reactome Pathway CCNB1 CDC25C CDK1 CHEK1 WEE1 +Cholesterol biosynthesis Reactome Pathway CYP51A1 DHCR24 DHCR7 EBP FDFT1 FDPS GGPS1 HMGCR HMGCS1 HSD17B7 IDI1 IDI2 LBR LSS MSMO1 MVD MVK NSDHL PMVK SC5D SQLE TM7SF2 +Chondroitin sulfate biosynthesis Reactome Pathway BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN NCAN VCAN +Chondroitin sulfate/dermatan sulfate metabolism Reactome Pathway AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST14 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GXYLT1 GXYLT2 HEXA HEXB HSPG2 HYAL1 HYAL3 IDS IDUA NCAN SDC1 SDC2 SDC3 SDC4 UST VCAN +Chromatin modifying enzymes Reactome Pathway ACTB ACTL6A ACTL6B ARID1A ARID1B ARID2 ARID4A ARID4B ARID5B ASH2L ATF2 ATF7IP ATXN7 ATXN7L3 BRD1 BRD8 BRMS1 BRPF1 BRPF3 CARM1 CCDC101 CCND1 CDK4 CHD3 CHD4 CLOCK COPRS CREBBP CSRP2BP DMAP1 DNMT3A DR1 EHMT1 EHMT2 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 GATAD2A GATAD2B GPS2 H2AFB1 H2AFX H2AFZ HAT1 HCFC1 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AG HIST1H2AH HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST3H2A HIST3H2BB HMG20B IKBKAP ING3 ING4 ING5 JADE1 JADE2 JADE3 JAK2 KANSL1 KANSL2 KANSL3 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A KMT2A KMT2B KMT2C KMT2D KMT2E MBD3 MBIP MCRS1 MEAF6 MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 MTA1 MTA2 MTA3 NCOR1 NCOR2 NSD1 OGT PBRM1 PHF2 PHF20 PHF21A PHF8 PRDM8 PRDM9 PRMT1 PRMT5 PRMT6 PRMT7 RBBP4 RBBP5 RBBP7 RCOR1 REST RUVBL1 RUVBL2 SAP130 SAP18 SAP30 SAP30L SETD1A SETD1B SETD2 SETD7 SETDB1 SETDB2 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMYD2 SMYD3 SUDS3 SUPT20H SUPT3H SUPT7L SUV39H1 SUV39H2 TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TBL1X TBL1XR1 TRRAP USP22 VPS72 WDR5 WDR77 WHSC1 WHSC1L1 YEATS2 YEATS4 ZZZ3 +Chromatin organization Reactome Pathway ACTB ACTL6A ACTL6B ARID1A ARID1B ARID2 ARID4A ARID4B ARID5B ASH2L ATF2 ATF7IP ATXN7 ATXN7L3 BRD1 BRD8 BRMS1 BRPF1 BRPF3 CARM1 CCDC101 CCND1 CDK4 CHD3 CHD4 CLOCK COPRS CREBBP CSRP2BP DMAP1 DNMT3A DR1 EHMT1 EHMT2 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 GATAD2A GATAD2B GPS2 H2AFB1 H2AFX H2AFZ HAT1 HCFC1 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AG HIST1H2AH HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST3H2A HIST3H2BB HMG20B IKBKAP ING3 ING4 ING5 JADE1 JADE2 JADE3 JAK2 KANSL1 KANSL2 KANSL3 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A KMT2A KMT2B KMT2C KMT2D KMT2E MBD3 MBIP MCRS1 MEAF6 MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 MTA1 MTA2 MTA3 NCOR1 NCOR2 NSD1 OGT PBRM1 PHF2 PHF20 PHF21A PHF8 PRDM8 PRDM9 PRMT1 PRMT5 PRMT6 PRMT7 RBBP4 RBBP5 RBBP7 RCOR1 REST RUVBL1 RUVBL2 SAP130 SAP18 SAP30 SAP30L SETD1A SETD1B SETD2 SETD7 SETDB1 SETDB2 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMYD2 SMYD3 SUDS3 SUPT20H SUPT3H SUPT7L SUV39H1 SUV39H2 TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TBL1X TBL1XR1 TRRAP USP22 VPS72 WDR5 WDR77 WHSC1 WHSC1L1 YEATS2 YEATS4 ZZZ3 +Chromosome Maintenance Reactome Pathway ACD APEX1 APITD1 CASC5 CENPA CENPC CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CENPW DKC1 DNA2 FEN1 H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 HJURP ITGB3BP LIG1 MIS18A MIS18BP1 NHP2 NPM1 OIP5 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POT1 PRIM1 PRIM2 RBBP4 RBBP7 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RSF1 RUVBL1 RUVBL2 SMARCA5 STRA13 TERF1 TERF2 TERF2IP TERT TINF2 WRAP53 +Chylomicron-mediated lipid transport Reactome Pathway APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE HSPG2 LDLR LDLRAP1 LIPC LPL MTTP P4HB SAR1B SDC1 +Circadian Clock Reactome Pathway ARNTL ARNTL2 ATF2 AVP BHLHE40 BHLHE41 BTRC CARM1 CCRN4L CHD9 CLOCK CPT1A CREB1 CREBBP CRY1 CRY2 CSNK1D CSNK1E CUL1 DBP ELOVL3 EP300 F7 FBXL3 HDAC3 HELZ2 HIF1A MED1 MEF2C MEF2D NAMPT NCOA1 NCOA2 NCOA6 NCOR1 NPAS2 NR1D1 NR3C1 PER1 PER2 PPARA PPARGC1A RORA RPS27A RXRA SERPINE1 SKP1 SMARCD3 SREBF1 TBL1X TBL1XR1 TGS1 UBA52 UBB UBC +Citric acid cycle (TCA cycle) Reactome Pathway ACO2 CS DLD DLST FH IDH2 IDH3A IDH3B IDH3G MDH2 NNT OGDH SDHA SDHB SDHC SDHD SUCLA2 SUCLG1 SUCLG2 +Class A/1 (Rhodopsin-like receptors) Reactome Pathway ACKR1 ACKR2 ACKR3 ACKR4 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 ANXA1 APLN APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DRD1 DRD2 DRD3 DRD4 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR1 FPR2 FPR3 FSHB FSHR GAL GALR1 GALR2 GALR3 GHRL GHSR GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GRP GRPR HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MT-RNR2 MTNR1A MTNR1B NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PYY QRFP QRFPR RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TSHB TSHR UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 +Class B/2 (Secretin family receptors) Reactome Pathway ADCYAP1 ADCYAP1R1 ADM ADM2 CALCA CALCB CALCR CALCRL CD55 CD97 CRH CRHR1 CRHR2 DHH EMR1 EMR2 EMR3 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IAPP IHH PTCH1 PTCH2 PTH PTH1R PTH2 PTH2R PTHLH RAMP1 RAMP2 RAMP3 SCT SCTR SHH SMO WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +Class C/3 (Metabotropic glutamate/pheromone receptors) Reactome Pathway CASR GABBR1 GABBR2 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 +Class I MHC mediated antigen processing & presentation Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ARIH2 ASB1 ASB10 ASB11 ASB12 ASB13 ASB14 ASB15 ASB16 ASB17 ASB18 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 B2M BLMH BTRC CALR CANX CBLB CD207 CD36 CDC16 CDC20 CDC23 CDC26 CDC27 CDC34 CTSL CTSS CTSV CUL1 CUL2 CUL3 CUL5 CUL7 CYBA CYBB DET1 DTX3L DZIP3 ERAP1 ERAP2 FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCGR1A FCGR1B FZR1 GAN HECTD3 HERC2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HSPA5 HUWE1 ITCH ITGAV ITGB5 KEAP1 KLHL13 KLHL20 KLHL21 KLHL9 LNPEP LRR1 LRRC41 LRSAM1 MGRN1 MKRN1 MRC1 MRC2 NCF1 NCF2 NCF4 NEDD4 NEDD4L NPEPPS PARK2 PDIA3 PJA1 PJA2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBCK1 RBX1 RCHY1 RNF111 RNF123 RNF138 RNF144B RNF182 RNF19B RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SPSB1 SPSB2 SPSB4 STUB1 TAP1 TAP2 TAPBP TCEB1 TCEB2 TPP2 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 UBA1 UBA3 UBA5 UBA52 UBA6 UBA7 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 VHL VPRBP WSB1 WWP1 ZBTB16 +Class II GLUTs Reactome Pathway SLC2A11 SLC2A5 SLC2A7 SLC2A9 +Classical Kir channels Reactome Pathway KCNJ12 KCNJ14 KCNJ2 KCNJ4 +Classical antibody-mediated complement activation Reactome Pathway C1QA C1QB C1QC C1R C1S CRP IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 +Clathrin derived vesicle budding Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 CLINT1 CLTA CLTC CPD CTSZ DNAJC6 DNASE2 DNM2 DTNBP1 FTH1 FTL GAK GBF1 GNS HIP1R HSPA8 IGF2R M6PR NAPA NECAP1 OCRL PICALM PIK3C2A PUM1 RAB5C SH3D19 SH3GL2 SNAP23 SNAPIN SNX2 SNX5 SNX9 SORT1 STX4 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 +Clearance of Nuclear Envelope Membranes from Chromatin Reactome Pathway BANF1 EMD LEMD2 LEMD3 TMPO VRK1 VRK2 +Cleavage of Growing Transcript in the Termination Region Reactome Pathway ALYREF CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 LSM10 LSM11 MAGOH NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 U2AF1 U2AF2 UPF3B ZNF473 +Cleavage of the damaged purine Reactome Pathway MPG MUTYH OGG1 +Cleavage of the damaged pyrimidine Reactome Pathway CCNO MBD4 NTHL1 SMUG1 TDG UNG +Cobalamin (Cbl, vitamin B12) transport and metabolism Reactome Pathway ABCC1 ABCD4 AMN CD320 CTRB1 CTRB2 CUBN GIF LMBRD1 MMAA MMAB MMACHC MMADHC MTR MTRR MUT PRSS1 PRSS3 TCN1 TCN2 +Coenzyme A biosynthesis Reactome Pathway COASY PANK1 PANK2 PANK3 PANK4 PPCDC PPCS SLC25A16 +Cohesin Loading onto Chromatin Reactome Pathway MAU2 NIPBL PDS5A PDS5B RAD21 SMC1A SMC3 STAG1 STAG2 WAPAL +Collagen biosynthesis and modifying enzymes Reactome Pathway ADAMTS14 ADAMTS2 ADAMTS3 BMP1 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLGALT1 COLGALT2 CRTAP LEPRE1 LEPREL1 LEPREL2 P4HB PCOLCE PCOLCE2 PLOD1 PLOD2 PLOD3 PPIB SERPINH1 TLL1 TLL2 +Collagen degradation Reactome Pathway ADAM10 ADAM17 ADAM9 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL23A1 COL25A1 COL26A1 COL9A1 COL9A2 COL9A3 CTSB CTSD CTSK CTSL ELANE FURIN MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 PRSS2 +Collagen formation Reactome Pathway ADAMTS14 ADAMTS2 ADAMTS3 BMP1 CD151 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLGALT1 COLGALT2 CRTAP CTSB CTSL CTSS CTSV DST ITGA6 ITGB4 LAMA3 LAMB3 LAMC2 LEPRE1 LEPREL1 LEPREL2 LOX LOXL1 LOXL2 LOXL3 LOXL4 MMP13 MMP20 MMP3 MMP7 MMP9 P4HB PCOLCE PCOLCE2 PLEC PLOD1 PLOD2 PLOD3 PPIB SERPINH1 TLL1 TLL2 +Common Pathway Reactome Pathway CD177 F10 F13A1 F13B F2 F2R F5 F8 FGA FGB FGG PF4 PF4V1 PROC PROCR PROS1 PRTN3 SERPINA5 SERPINC1 SERPIND1 SERPINE2 THBD +Complement cascade Reactome Pathway C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CFB CFD CFH CFHR3 CFI CR1 CRP FCN1 FCN2 FCN3 GZMM IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 MASP1 MASP2 MBL2 PROS1 VTN +Condensation of Prometaphase Chromosomes Reactome Pathway CCNB1 CCNB2 CDK1 CSNK2A1 CSNK2A2 CSNK2B NCAPD2 NCAPG NCAPH SMC2 SMC4 +Condensation of Prophase Chromosomes Reactome Pathway CCNB1 CDK1 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 MCPH1 NCAPD3 NCAPG2 NCAPH2 PHF8 PLK1 RB1 SET SETD8 SMC2 SMC4 +Conjugation of benzoate with glycine Reactome Pathway ACSM1 ACSM2B GLYAT GLYATL1 GLYATL2 +Conjugation of carboxylic acids Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 GLYAT GLYATL1 GLYATL2 +Conjugation of phenylacetate with glutamine Reactome Pathway ACSM1 ACSM2B +Conjugation of salicylate with glycine Reactome Pathway ACSM2A ACSM2B ACSM4 ACSM5 GLYAT GLYATL1 GLYATL2 +Constitutive PI3K/AKT Signaling in Cancer Reactome Pathway AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MLST8 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 TRAT1 TSC2 VAV1 +Constitutive Signaling by EGFRvIII Reactome Pathway CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 SHC1 SOS1 +Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Reactome Pathway CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A SHC1 SOS1 UBA52 UBB UBC +Constitutive Signaling by NOTCH1 HD Domain Mutants Reactome Pathway ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 MIB1 MIB2 NEURL1 NEURL1B NOTCH1 RPS27A UBA52 UBB UBC +Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Reactome Pathway ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC +Constitutive Signaling by NOTCH1 PEST Domain Mutants Reactome Pathway ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC +Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Reactome Pathway ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 NOTCH1 +Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 FZR1 UBE2C UBE2D1 UBE2E1 +Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Reactome Pathway ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 +Costimulation by the CD28 family Reactome Pathway AKT1 AKT2 AKT3 BTLA CD247 CD274 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDC42 CSK CTLA4 FYN GRAP2 GRB2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICOS ICOSLG LCK LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PAK3 PDCD1 PDCD1LG2 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 PTPN6 RAC1 RICTOR SRC TCRA TCRB THEM4 TNFRSF14 TRAC TRBC1 TRBV12-3 TRIB3 VAV1 YES1 +Creatine metabolism Reactome Pathway CKB CKM CKMT1A CKMT2 GAMT GATM SLC6A11 SLC6A12 SLC6A7 SLC6A8 +Creation of C4 and C2 activators Reactome Pathway C1QA C1QB C1QC C1R C1S CRP FCN1 FCN2 FCN3 IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 MASP1 MASP2 MBL2 +Cross-presentation of particulate exogenous antigens (phagosomes) Reactome Pathway CD36 CYBA CYBB ITGAV ITGB5 NCF1 NCF2 NCF4 +Cross-presentation of soluble exogenous antigens (endosomes) Reactome Pathway CD207 FCGR1A FCGR1B MRC1 MRC2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 +Crosslinking of collagen fibrils Reactome Pathway BMP1 LOX LOXL1 LOXL2 LOXL3 LOXL4 PCOLCE TLL1 TLL2 +Cyclin A/B1 associated events during G2/M transition Reactome Pathway CCNA1 CCNA2 CCNB1 CCNB2 CCNH CDC25A CDC25B CDC25C CDK1 CDK2 CDK7 FOXM1 MNAT1 PKMYT1 PLK1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A WEE1 XPO1 +Cyclin A:Cdk2-associated events at S phase entry Reactome Pathway CCNA1 CCNA2 CCNE1 CCNE2 CCNH CDC25A CDC25B CDK2 CDK7 CDKN1A CDKN1B CKS1B CUL1 FZR1 MAX MNAT1 MYC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RB1 RPS27A SKP1 SKP2 UBA52 UBB UBC WEE1 +Cyclin B2 mediated events Reactome Pathway CCNB2 CDC25A CDC25B CDC25C CDK1 +Cyclin D associated events in G1 Reactome Pathway CCND1 CCND2 CCND3 CCNH CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CKS1B CUL1 E2F1 E2F2 E2F3 E2F4 E2F5 MNAT1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B RB1 RBL1 RBL2 RPS27A SKP1 SKP2 TFDP1 TFDP2 UBA52 UBB UBC +Cyclin E associated events during G1/S transition Reactome Pathway CCNA1 CCNA2 CCNE1 CCNE2 CCNH CDC25A CDK2 CDK7 CDKN1A CDKN1B CKS1B CUL1 MAX MNAT1 MYC PKMYT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RB1 RPS27A SKP1 SKP2 UBA52 UBB UBC WEE1 +Cysteine formation from homocysteine Reactome Pathway CBS CTH +Cytochrome P450 - arranged by substrate type Reactome Pathway CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR NCOA1 NCOA2 NR1H4 POMC PTGIS RXRA TBXAS1 +Cytochrome c-mediated apoptotic response Reactome Pathway APAF1 CASP3 CASP7 CASP9 CYCS +Cytokine Signaling in Immune system Reactome Pathway AAAS ADAM17 ADAR ARIH1 B2M BLNK BST2 BTRC CAMK2A CAMK2B CAMK2D CAMK2G CASP1 CBL CD44 CDK1 CHUK CIITA CISH CRK CRKL CSF2 CSF2RA CSF2RB CSH1 CUL1 DDX58 EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FCGR1A FCGR1B FLNB FYN GAB2 GBP1 GBP2 GBP3 GBP4 GBP5 GBP6 GBP7 GH1 GH2 GHR GRB2 HCK HERC5 HGF HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G HRAS ICAM1 IFI27 IFI30 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IKBKB IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPP5D INPPL1 IP6K2 IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 IRS1 IRS2 ISG15 ISG20 JAK1 JAK2 JAK3 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 KRAS LCK LYN MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK3 MID1 MT2A MX1 MX2 MYD88 NCAM1 NEDD4 NFKB1 NFKB2 NOD1 NOD2 NRAS NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL PELI1 PELI2 PELI3 PIAS1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIN1 PLCG1 PML POM121 PPM1B PRKACA PRKCD PRL PRLR PSMB8 PTAFR PTK2B PTPN1 PTPN11 PTPN2 PTPN6 RAE1 RAF1 RANBP2 RAPGEF1 RBX1 RELA RIPK2 RNASEL RPS27A RSAD2 SAMHD1 SEH1L SH2B1 SHC1 SKP1 SOCS1 SOCS2 SOCS3 SOS1 SP100 SQSTM1 STAT1 STAT2 STAT3 STAT5A STAT5B SUMO1 SYK TAB1 TAB2 TAB3 TEC TNIP2 TOLLIP TPR TRAF6 TRIM10 TRIM14 TRIM17 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM34 TRIM35 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM6 TRIM62 TRIM68 TRIM8 TYK2 UBA52 UBA7 UBB UBC UBE2E1 UBE2L6 UBE2N UBE2V1 USP18 USP41 VAV1 VCAM1 XAF1 YES1 YWHAB YWHAZ gag +Cytosolic iron-sulfur cluster assembly Reactome Pathway ABCB7 BRIP1 CIAO1 CIAPIN1 ERCC2 FAM96B MMS19 NARFL NDOR1 NUBP1 NUBP2 POLD1 RTEL1 +Cytosolic sensors of pathogen-associated DNA Reactome Pathway AGER APP CHUK CRCP CREBBP CTNNB1 DDX41 DHX36 DHX9 DTX4 EP300 HMGB1 IFI16 IKBKB IKBKG IRF3 IRF7 LRRFIP1 MB21D1 MRE11A MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K PRKDC RELA RIPK1 RIPK3 RPS27A S100A12 S100B SAA1 STAT6 TBK1 TICAM1 TLR3 TMEM173 TREX1 TRIM21 TRIM32 TRIM56 UBA52 UBB UBC XRCC5 XRCC6 ZBP1 +Cytosolic sulfonation of small molecules Reactome Pathway BPNT1 PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 +Cytosolic tRNA aminoacylation Reactome Pathway AARS AIMP1 AIMP2 CARS DARS EEF1E1 EPRS FARSA FARSB GARS HARS IARS KARS LARS MARS NARS PPA1 QARS RARS SARS TARS VARS WARS YARS +DAG and IP3 signaling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 ITPR1 ITPR2 ITPR3 PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +DAP12 interactions Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 B2M BAD BTC BTK CALM1 CAMK4 CASP9 CD19 CD28 CD300E CD300LB CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CLEC5A CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRAP2 GRB2 GSK3A GSK3B HBEGF HLA-B HLA-C HLA-E HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIR2DS2 KIR2DS4 KIR2DS5 KIR3DS1 KIT KITLG KL KLB KLRC2 KLRD1 KLRK1 KRAS LAT LCK LCP2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NCR2 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAC1 RAF1 RICTOR RPS6KB2 SHC1 SIGLEC14 SIGLEC15 SIGLEC16 SIRPB1 SOS1 SYK THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TREM1 TREM2 TRIB3 TSC2 TYK2 TYROBP VAV1 VAV2 VAV3 YWHAB +DAP12 signaling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 B2M BAD BTC BTK CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRAP2 GRB2 GSK3A GSK3B HBEGF HLA-E HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KLRC2 KLRD1 KLRK1 KRAS LAT LCK LCP2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAC1 RAF1 RICTOR RPS6KB2 SHC1 SOS1 SYK THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TREM2 TRIB3 TSC2 TYK2 TYROBP VAV1 VAV2 VAV3 YWHAB +DARPP-32 events Reactome Pathway CALM1 CDK5 PDE4A PDE4B PDE4C PDE4D PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +DCC mediated attractive signaling Reactome Pathway ABLIM1 ABLIM2 ABLIM3 CDC42 DCC DOCK1 FYN NCK1 NTN1 PTK2 RAC1 SRC TRIO WASL +DEx/H-box helicases activate type I IFN and inflammatory cytokines production Reactome Pathway AGER APP DHX36 DHX9 HMGB1 IRF7 MYD88 NFKB1 NFKB2 RELA S100A12 S100B SAA1 +DNA Damage Bypass Reactome Pathway MAD2L2 POLH REV1 REV3L +DNA Damage Recognition in GG-NER Reactome Pathway RAD23B XPC +DNA Damage Reversal Reactome Pathway ALKBH2 ALKBH3 MGMT +DNA Damage/Telomere Stress Induced Senescence Reactome Pathway ACD ASF1A ATM CABIN1 CCNA1 CCNA2 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B EP400 H1F0 H2AFB1 H2AFX H2AFZ H2BFS HIRA HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 HMGA1 HMGA2 LMNB1 MRE11A NBN POT1 RAD50 RB1 TERF1 TERF2 TERF2IP TINF2 TP53 UBN1 +DNA Repair Reactome Pathway ALKBH2 ALKBH3 APEX1 ATM ATR BRCA1 BRCA2 BRIP1 CCNH CCNO CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 EXO1 FAAP100 FAAP24 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM FEN1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFX LIG1 LIG3 LIG4 MAD2L2 MBD4 MDC1 MGMT MLH1 MNAT1 MPG MRE11A MSH2 MSH3 MSH6 MUTYH NBN NTHL1 OGG1 PALB2 PCNA PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRKDC RAD23B RAD50 RAD51 RAD52 REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SMUG1 TCEA1 TDG TDP1 TP53BP1 UBA52 UBB UBC UBE2T UNG USP1 XAB2 XPA XPC XRCC1 XRCC4 XRCC5 XRCC6 ZBTB32 +DNA Replication Reactome Pathway APEX1 CCNA1 CCNA2 CDC45 CDC6 CDC7 CDK2 CDKN1A CDKN1B CDT1 DBF4 DNA2 E2F1 E2F2 E2F3 FEN1 FZR1 GINS1 GINS2 GINS4 GMNN LIG1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 RPS27A UBA52 UBB UBC +DNA Replication Pre-Initiation Reactome Pathway CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 E2F1 E2F2 E2F3 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPA1 RPA2 RPA3 RPA4 RPS27A UBA52 UBB UBC +DNA methylation Reactome Pathway DNMT1 DNMT3A DNMT3B DNMT3L H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB UHRF1 +DNA replication initiation Reactome Pathway POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 +DNA strand elongation Reactome Pathway APEX1 CDC45 DNA2 FEN1 GINS1 GINS2 GINS4 LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +DSCAM interactions Reactome Pathway DCC DSCAM DSCAML1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 NTN1 PAK1 RAC1 +Deadenylation of mRNA Reactome Pathway CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 PABPC1 PAIP1 PAN2 PAN3 PARN RQCD1 TNKS1BP1 +Deadenylation-dependent mRNA decay Reactome Pathway CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 DCP1A DCP1B DCP2 DCPS DDX6 DIS3 EDC3 EDC4 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 PABPC1 PAIP1 PAN2 PAN3 PARN PATL1 RQCD1 TNKS1BP1 XRN1 +Death Receptor Signalling Reactome Pathway ADAM17 CASP10 CASP8 CFLAR FADD FAS FASLG TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFSF10 +Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Reactome Pathway ACKR1 ACKR2 ACKR3 ACKR4 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 ANXA1 APLN APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CASR CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD55 CD97 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CRH CRHR1 CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DHH DRD1 DRD2 DRD3 DRD4 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MT-RNR2 MTNR1A MTNR1B NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTCH1 PTCH2 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHH SMO SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TRH TRHR TSHB TSHR UTS2 UTS2B UTS2R WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 +Defective ACY1 causes encephalopathy Reactome Pathway ACY1 ACY3 AKR7A2 AKR7A3 AKR7L CYP1A2 CYP2A13 CYP3A4 CYP3A5 DPEP1 DPEP2 DPEP3 GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 MGST1 MGST2 MGST3 +Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective ALG1 causes ALG1-CDG (CDG-1k) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG11 causes ALG11-CDG (CDG-1p) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG12 causes ALG12-CDG (CDG-1g) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG2 causes ALG2-CDG (CDG-1i) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG3 causes ALG3-CDG (CDG-1d) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG6 causes ALG6-CDG (CDG-1c) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG8 causes ALG8-CDG (CDG-1h) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective ALG9 causes ALG9-CDG (CDG-1l) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective AMN causes hereditary megaloblastic anemia 1 Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective B3GAT3 causes JDSSDHD Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective B4GALT7 causes EDS, progeroid type Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective BTD causes biotidinase deficiency Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective CD320 causes methylmalonic aciduria Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective CHST14 causes EDS, musculocontractural type Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective CHST3 causes SEDCJD Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective CHST6 causes MCDC1 Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective CHSY1 causes TPBS Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective CUBN causes hereditary megaloblastic anemia 1 Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP1B1 causes Glaucoma Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective EXT1 causes exostoses 1, TRPS2 and CHDS Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective EXT2 causes exostoses 2 Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective FMO3 causes Trimethylaminuria (TMAU) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective GGT1 causes Glutathionuria (GLUTH) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective GIF causes intrinsic factor deficiency Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective HLCS causes multiple carboxylase deficiency Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MAN1B1 causes MRT15 Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective MAOA causes Brunner syndrome (BRUNS) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective MGAT2 causes MGAT2-CDG (CDG-2a) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective MMAA causes methylmalonic aciduria type cblA Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MMAB causes methylmalonic aciduria type cblB Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MOGS causes MOGS-CDG (CDG-2b) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective MPDU1 causes MPDU1-CDG (CDG-1f) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective MUT causes methylmalonic aciduria mut type Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective PAPSS2 causes SEMD-PA Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective RFT1 causes RFT1-CDG (CDG-1n) Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Defective SLC26A2 causes chondrodysplasias Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Defective TCN2 causes hereditary megaloblastic anemia Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective UGT1A1 causes hyperbilirubinemia Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defective UGT1A4 causes hyperbilirubinemia Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Defects in biotin (Btn) metabolism Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defects in cobalamin (B12) metabolism Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defects in vitamin and cofactor metabolism Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Defensins Reactome Pathway ART1 CCR2 CCR6 CD4 DEFA1 DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB104A DEFB105A DEFB106A DEFB107A DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB4A PRSS2 PRSS3 TLR1 TLR2 env +Degradation of GABA Reactome Pathway ABAT ALDH5A1 +Degradation of GLI1 by the proteasome Reactome Pathway BTRC CUL1 GLI1 ITCH NUMB PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 SUFU UBA52 UBB UBC +Degradation of GLI2 by the proteasome Reactome Pathway BTRC CSNK1A1 CUL1 GLI2 GSK3B PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 SUFU UBA52 UBB UBC +Degradation of beta-catenin by the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Degradation of cysteine and homocysteine Reactome Pathway CDO1 CSAD CTH ETHE1 SLC25A10 SQRDL SUOX TST +Degradation of the extracellular matrix Reactome Pathway A2M ACAN ADAM10 ADAM15 ADAM17 ADAM8 ADAM9 ADAMTS1 ADAMTS16 ADAMTS18 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 BCAN BMP1 BSG CAPN1 CAPNS1 CASP3 CD44 CDH1 CMA1 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL23A1 COL25A1 COL26A1 COL9A1 COL9A2 COL9A3 CTRB1 CTRB2 CTSB CTSD CTSG CTSK CTSL CTSS CTSV DCN ELANE FURIN HSPG2 KLK2 KLK7 KLKB1 LAMA3 LAMA5 LAMB1 LAMB3 LAMC1 LAMC2 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 NCSTN NID1 PLG PRSS1 PRSS2 PSEN1 SPP1 TIMP1 TIMP2 TLL1 TLL2 TPSAB1 +Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Reactome Pathway CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4 +Depolymerisation of the Nuclear Lamina Reactome Pathway CCNB1 CDK1 CNEP1R1 CTDNEP1 EMD LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 PRKCA PRKCB TMPO +Deposition of new CENPA-containing nucleosomes at the centromere Reactome Pathway APITD1 CASC5 CENPA CENPC CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CENPW H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HJURP ITGB3BP MIS18A MIS18BP1 NPM1 OIP5 RBBP4 RBBP7 RSF1 RUVBL1 SMARCA5 STRA13 +Depurination Reactome Pathway MPG MUTYH OGG1 +Depyrimidination Reactome Pathway CCNO MBD4 NTHL1 SMUG1 TDG UNG +Dermatan sulfate biosynthesis Reactome Pathway BCAN BGN CHST14 CSPG4 CSPG5 DCN DSE DSEL NCAN UST VCAN +Detoxification of Reactive Oxygen Species Reactome Pathway AQP8 ATOX1 ATP7A CAT CCS CYCS ERO1L GPX1 GPX2 GPX3 GPX7 GPX8 GSR GSTP1 P4HB PRDX1 PRDX2 PRDX3 PRDX5 PRDX6 SOD1 SOD2 SOD3 TXN TXN2 TXNRD1 TXNRD2 +Developmental Biology Reactome Pathway ABL1 ABL2 ABLIM1 ABLIM2 ABLIM3 ACTB ACTG1 ACTR2 ACTR3 ACVR1B ACVR1C ACVR2A ACVR2B ADAM10 ADIPOQ AGAP2 AGRN AKT1 AKT2 AKT3 ALCAM ANGPTL4 ANK1 ANK2 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGAP35 ARHGAP39 ARHGEF11 ARHGEF12 ARHGEF28 ARHGEF7 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ARTN BNIP2 BOC CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CAP1 CAP2 CARM1 CCNC CCND3 CD24 CD36 CD72 CDC42 CDH15 CDH2 CDH4 CDK1 CDK19 CDK4 CDK5 CDK5R1 CDK8 CDON CDX2 CEBPA CEBPB CEBPD CER1 CFC1 CFL1 CHD9 CHL1 CLASP1 CLASP2 CLTA CLTB CLTC CLTCL1 CNTN1 CNTN2 CNTN6 CNTNAP1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CREB1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CSNK2B CTNNA1 CTNNA2 CTNNB1 DCC DCX DKK1 DLG1 DLG3 DLG4 DNM1 DNM2 DNM3 DOCK1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 DRAP1 EBF1 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EGFR EGR2 ENAH EOMES EP300 EPAS1 EPAS1 (HIF2A) EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 ERBB2 EVL EZR FABP4 FARP2 FES FGF10 FGF2 FGFR1 FOXA2 FOXA3 FOXD3 FOXH1 FOXO1 FOXO3 FURIN FYN GATA6 GCK GDF1 GDNF GFRA1 GFRA2 GFRA4 GIT1 GPC1 GRB2 GRIN1 GRIN2B GSC GSK3B HDAC3 HELZ2 HES1 HFE2 HHEX HIF3A HNF1A HNF1B HNF4A HNF4G HRAS HSP90AA1 HSP90AB1 HSPA8 IAPP IL6 IL6R IL6ST INS INSM1 ITGA1 ITGA10 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 ITSN1 JAK1 JAK2 KALRN KCNQ2 KCNQ3 KDR KIAA1598 KIF4A KIF4B KLF4 KLF5 KRAS L1CAM LAMA1 LAMB1 LAMC1 LEFTY1 LEFTY2 LEP LIMK1 LIMK2 LIN28A LPL LYN MAFA MAP2K1 MAP2K2 MAP2K6 MAPK1 MAPK11 MAPK12 MAPK14 MAPK3 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MEF2A MEF2B MEF2C MEF2D MET MMP2 MMP9 MSN MYF5 MYF6 MYH10 MYH11 MYH14 MYH9 MYL12A MYL12B MYL6 MYL9 MYO10 MYOD1 MYOG NANOG NCAM1 NCAN NCK1 NCK2 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NCSTN NEO1 NEUROD1 NEUROG3 NFASC NFKB1 NGEF NKX2-2 NKX6-1 NODAL NOTCH1 NR2F2 NR5A1 NR5A2 NR6A1 NRAS NRCAM NRP1 NRP2 NRTN NTN1 NTN3 NTN4 NUMB ONECUT1 ONECUT3 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PAX4 PAX6 PBX1 PCK1 PCSK6 PDX1 PFN1 PFN2 PIP5K1C PITPNA PKLR PLCG1 PLIN1 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB3 PLXNC1 PLXND1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU5F1 POU5F1 (OCT4) PPARA PPARG PPARGC1A PRDM14 PRKCQ PRNP PSEN2 PSENEN PSPN PTF1A PTK2 PTPN11 PTPRA PTPRC RAC1 RAC2 RAF1 RANBP9 RASA1 RBPJ RDX RELA RGMA RGMB RHOA RHOB RHOC RHOG RND1 ROBO1 ROBO2 ROBO3 ROCK1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS RXRA SALL4 SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SDC2 SDCBP SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A SH3GL2 SHB SIAH1 SIAH2 SLC2A2 SLC2A4 SLIT1 SLIT2 SLIT3 SMAD2 SMAD3 SMAD4 SMARCD3 SOS1 SOS2 SOX2 SPAG9 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC SREBF1 SREBF2 SRGAP1 SRGAP2 SRGAP3 ST8SIA2 ST8SIA4 STAT3 TBL1X TBL1XR1 TCF12 TCF3 TCF4 TDGF1 TGFB1 TGS1 TIAM1 TLN1 TNF TREM2 TRIO TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TSC22D1 TYK2 TYROBP UNC5A UNC5B UNC5C UNC5D VASP VAV2 VAV3 VEGFA WASL WNT1 WNT10B YES1 YWHAB ZIC3 ZSCAN10 +Digestion of dietary carbohydrate Reactome Pathway AMY1A AMY1B AMY2A AMY2B LCT MGAM SI TREH +Digestion of dietary lipid Reactome Pathway CEL CLPS PNLIP PNLIPRP1 PNLIPRP2 +Dimerization of procaspase-8 Reactome Pathway CASP8 CFLAR FADD FAS FASLG RIPK1 TNFRSF10A TNFRSF10B TNFSF10 TRADD TRAF2 +Disease Reactome Pathway AAAS AASDHPPT ABCA4 ABCC1 ABCC5 ABCD4 ACACA ACACB ACAN ACKR1 ACKR2 ACKR3 ACKR4 ACP5 ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 ACSS1 ACSS2 ACY1 ACY3 ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 AES AGL AGO1 AGO2 AGO3 AGO4 AGRN AGT AGTR1 AGTR2 AHCY AKR1B10 AKR1C1 AKR1C3 AKR1C4 AKR7A2 AKR7A3 AKR7L AKT1 AKT1S1 AKT2 AKT3 ALDH1A1 ALDH2 ALDOA ALDOB ALDOC ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 AMER1 AMN AMY1A AMY1B AMY2A AMY2B ANTXR1 ANTXR2 ANXA1 AOX1 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APC APCS APH1A APH1B APLN APLNR APOA1 APOA2 APOA4 APOB APOBEC3G APOC2 APOC3 APOE APP ARF1 ARHGEF18 ARHGEF7 ARRB1 ARRB2 ARSB ASH2L ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H AVP AVPR1A AVPR1B AVPR2 AXIN1 AXIN2 B2M B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BAD BAMBI BANF1 BCAN BCL9 BCL9L BCO1 BCO2 BCR BDKRB1 BDKRB2 BGN BPNT1 BRAF BRS3 BTC BTD BTRC C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CALM1 CALR CAMK4 CAMP CANX CASP9 CASR CAV1 CBL CBY1 CCBL1 CCDC88C CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCNC CCNH CCNT1 CCNT2 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD19 CD247 CD28 CD320 CD4 CD44 CD55 CD80 CD86 CD8B CD9 CD97 CDC37 CDC42 CDC73 CDK1 CDK7 CDK8 CDK9 CDKN1A CDKN1B CDKN2B CGA CGN CHD8 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CHP1 CHPF CHPF2 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CHUK CLPS CLTA CMAS CNDP2 CNGA1 CNGB1 CNR1 CNR2 CNTN1 CNTRL COASY COMT CPSF4 CPSF6 CREB1 CREBBP CRH CRHR1 CRHR2 CSGALNACT1 CSGALNACT2 CSK CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CSPG4 CSPG5 CST3 CTBP1 CTBP2 CTDP1 CTNNB1 CTNNBIP1 CTRB1 CTRB2 CTSA CUBN CUL1 CUL3 CUL5 CUX1 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXXC4 CYB5A CYB5R3 CYBA CYBB CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 CYSLTR1 CYSLTR2 DACT1 DAD1 DCN DDOST DERL2 DHDDS DHFR DHFRL1 DHH DHRS3 DHRS9 DISP2 DKK1 DKK2 DKK4 DLK1 DLL1 DLL4 DNAJC3 DNER DOCK2 DOLK DOLPP1 DPAGT1 DPEP1 DPEP2 DPEP3 DPM1 DPM2 DPM3 DRD1 DRD2 DRD3 DRD4 DRD5 DSE DSEL DTX1 DTX2 DTX4 DVL1 DVL2 DVL3 E2F4 E2F5 EDEM1 EDEM2 EDEM3 EDN1 EDN2 EDN3 EDNRA EDNRB EEF2 EGF EGFR EIF2AK2 ELL ELMO1 EMR1 EMR2 EMR3 ENO1 ENO2 ENO3 ENPP1 EP300 EPM2A EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 ERCC2 ERCC3 EREG ERLEC1 EXT1 EXT2 F11R F2 F2R F2RL1 F2RL2 F2RL3 FASN FAU FBP1 FBP2 FBXW7 FDX1 FDX1L FDXR FEN1 FFAR1 FFAR2 FFAR3 FFAR4 FGA FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FGFR2 FGFR3 FGFR4 FKBP1A FLAD1 FMO1 FMO2 FMO3 FMOD FNTA FNTB FOXO1 FOXO3 FOXO4 FPGS FPR1 FPR2 FPR3 FRAT1 FRAT2 FRS2 FRS3 FSHB FSHR FURIN FUT8 FYN FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 G6PC G6PC2 G6PC3 G6PD GAB1 GAB2 GABBR1 GABBR2 GAL GALE GALK1 GALR1 GALR2 GALR3 GALT GANAB GAPDH GAPDHS GBE1 GCG GCGR GCK GCKR GCLC GCLM GFPT1 GFPT2 GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GHRH GHRHR GHRL GHSR GIF GIP GIPR GLB1 GLB1L GLCE GLP1R GLP2R GLYAT GLYATL1 GLYATL2 GMPPA GMPPB GNAS GNAT1 GNB1 GNB2 GNB3 GNB4 GNB5 GNE GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNPNAT1 GNRH1 GNRH2 GNRHR GNRHR2 GNS GOT1 GOT2 GPBAR1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPER1 GPHN GPI GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRB2 GRK1 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR GRSF1 GSK3A GSK3B GSN GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HA HA-33 HAS1 HAS2 HAS3 HBEGF HCAR1 HCAR2 HCAR3 HCK HCRT HCRTR1 HCRTR2 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HEBP1 HECW1 HES1 HES5 HEXA HEXB HEY1 HEY2 HEYL HGS HHAT HIF1A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HK1 HK2 HK3 HLA-A HLCS HMGA1 HMMR HPGDS HPSE HPSE2 HRAS HRH1 HRH2 HRH3 HRH4 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSD17B1 HSD17B6 HSP90AA1 HSP90AB1 HSPA1A HSPG2 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 HYAL1 HYAL2 HYAL3 IAPP IDH1 IDS IDUA IHH IL17RD IL4I1 IL6 IL6R IL6ST INS INSL3 INSL5 IPO5 IRS1 IRS2 ITCH ITM2B ITPR1 ITPR2 ITPR3 JAG1 JAG2 JAK1 JAK2 JUNB KAT2A KAT2B KAT5 KERA KHK KISS1 KISS1R KIT KITLG KL KLB KLHL12 KMT2D KNG1 KPNA1 KPNB1 KRAS KREMEN1 KREMEN2 LCK LCT LDHB LDLR LEF1 LEO1 LGR4 LGR5 LGR6 LHB LHCGR LIG1 LIG4 LMAN1 LMBRD1 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LPL LRAT LRIG1 LRP1 LRP10 LRP12 LRP2 LRP5 LRP6 LRP8 LRRFIP1 LTB4R LTB4R2 LTF LUM LYVE1 LYZ M MAGT1 MAML1 MAML2 MAML3 MAMLD1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MAOA MAOB MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK1 MAPK3 MAPKAP1 MAT1A MAT2A MAT2B MC1R MC2R MC3R MC4R MC5R MCCC1 MCCC2 MCFD2 MCHR1 MCHR2 MDH1 MDH2 MDM2 MEN1 METAP1 METAP2 MFGE8 MGAM MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MGST1 MGST2 MGST3 MIB1 MIB2 MIR26A1 MIR26A2 MKNK1 MLEC MLN MLNR MLST8 MMAA MMAB MMACHC MMADHC MNAT1 MOCOS MOCS1 MOCS2 MOCS3 MOGS MOV10 MPDU1 MPI MT-RNR2 MT2748 MTHFD1 MTHFR MTMR4 MTNR1A MTNR1B MTOR MTR MTRR MUT MVD MYC MYO18A MYO7A NA NADK NADSYN1 NAGLU NAMPT NANP NANS NAPEPLD NAPRT NAT1 NAT2 NCAN NCBP1 NCBP2 NCF1 NCF2 NCF4 NCOA1 NCOA2 NCOR1 NCOR2 NCSTN NDST1 NDST2 NDST3 NDST4 NEDD4L NEDD8 NELFA NELFB NELFCD NELFE NEU1 NEU2 NEU3 NEU4 NEURL1 NEURL1B NFS1 NHLRC1 NMB NMBR NMNAT1 NMNAT2 NMNAT3 NMS NMT1 NMT2 NMU NMUR1 NMUR2 NNMT NOS1 NOS2 NOS3 NOTCH1 NOTUM NP NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPL NPM1 NPPA NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NR1H4 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 NS NTS NTSR1 NTSR2 NUMB NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 ODAM OGN OMD OPLAH OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OS9 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P4HB PA PABPN1 PACS1 PAG1 PAH PAK2 PANK1 PANK2 PANK3 PANK4 PAOX PAPSS1 PAPSS2 PARD3 PARD6A PARP1 PB1 PB2 PC PCCA PCCB PCK1 PCK2 PDCD6IP PDE1A PDE1B PDE1C PDE6A PDE6B PDE6G PDGFA PDGFB PDGFRA PDGFRB PDIA3 PDPK1 PDXK PDYN PDZD11 PENK PF4 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PGM3 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP5K1B PKLR PKM PLB1 PLCG1 PMCH PMEPA1 PMM1 PMM2 PNLIP PNOC PNPO POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 POMC PORCN PPBP PPCDC PPCS PPEF1 PPIA PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPY PREB PRELP PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PRKCQ PRKCSH PRKCZ PRL PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PRPS1 PRPS1L1 PRPS2 PRSS1 PRSS3 PSAP PSEN2 PSENEN PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTAFR PTCH1 PTCH2 PTEN PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTGIS PTGS1 PTGS2 PTH PTH1R PTH2 PTH2R PTHLH PTPN11 PXN PYGB PYGL PYGM PYGO1 PYGO2 PYY QPRT QRFP QRFPR RAC1 RAE1 RAF1 RAMP1 RAMP2 RAMP3 RAN RANBP1 RANBP2 RANGAP1 RBBP5 RBL1 RBP1 RBP2 RBP3 RBP4 RBPJ RBX1 RCC1 RCVRN RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RFK RFT1 RGR RGS9 RGS9BP RHO RHOA RICTOR RLBP1 RLN2 RLN3 RNF111 RNF146 RNF43 RNGTT RNMT RPE RPE65 RPIA RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS6KB2 RPS7 RPS8 RPS9 RPSA RRH RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RXFP1 RXFP2 RXFP3 RXFP4 RXRA RYK Rv1280c Rv1281c Rv1282c Rv1283c Rv2238c Rv2895c S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SAG SAR1B SCT SCTR SCUBE2 SDC1 SDC2 SDC3 SDC4 SDR9C7 SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEH1L SEL1L SEMG1 SERPINE1 SFRP1 SFRP2 SGSH SH3GL2 SH3KBP1 SHC1 SHH SHMT1 SI SKI SKIL SKP1 SLC11A1 SLC17A5 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC24A1 SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A16 SLC25A32 SLC25A4 SLC25A5 SLC25A6 SLC26A1 SLC26A2 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC35A1 SLC35B2 SLC35B3 SLC35D1 SLC35D2 SLC37A4 SLC46A1 SLC52A3 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A6 SLC5A9 SLC9A1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMO SMOX SMURF1 SMURF2 SNAP25 SNCA SNW1 SNX3 SOS1 SOST SP1 SPRY1 SPRY2 SRC SRD5A3 SSRP1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STAB2 STAM STAM2 STAT1 STAT3 STAT5A STAT5B STRA6 STRAP STT3A STUB1 STX1A STX1B SUCNR1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SUPT16H SUPT4H1 SUPT5H SV2A SV2B SV2C SYT1 SYT2 SYVN1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TALDO1 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBL1X TBL1XR1 TBP TBXA2R TBXAS1 TCEA1 TCEB1 TCEB2 TCEB3 TCF4 TCF7 TCF7L1 TCF7L2 TCIRG1 TCN1 TCN2 TERT TFDP1 TFDP2 TGFB1 TGFBI TGFBR1 TGFBR2 TGIF1 TGIF2 THEM4 THTPA TKT TLE1 TLE2 TLE3 TLE4 TMED5 TNKS TNKS2 TNRC6A TNRC6B TNRC6C TPI1 TPK1 TPMT TPR TRAT1 TREH TRH TRHR TRIB3 TRIM24 TRIM33 TRRAP TSC2 TSG101 TSHB TSHR TTR TUSC3 TXNRD1 TYK2 UAP1 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 UGDH UGGT1 UGGT2 UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 USP15 USP34 USP8 USP9X UST UTS2 UTS2B UTS2R VAMP1 VAMP2 VAV1 VCAN VCP VPS26A VPS28 VPS29 VPS35 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 WIF1 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WWTR1 XCL1 XCL2 XCR1 XIAP XPO1 XRCC4 XRCC5 XRCC6 YWHAB YWHAZ ZFYVE9 ZMYM2 ZNRF3 adhE2 ahpC ahpD bfr bfrB botA botB botD botF botG cya dlaT env fgd1 gag gag-pol ggtA glbN ha17 ha70 irtA irtB katG lef lpdC msrA nef ntnha pagA rev secA1 secA2 secD secE secF secG secY sodB sodC tat tetX tpx trx-2 trxA trxB vif vpr vpu +Diseases associated with N-glycosylation of proteins Reactome Pathway ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX CMAS CTSA DAD1 DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STT3A TUSC3 UAP1 UGGT1 UGGT2 +Diseases associated with glycosaminoglycan metabolism Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Diseases associated with visual transduction Reactome Pathway ABCA4 AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE BCO1 BCO2 CALM1 CLPS CNGA1 CNGB1 DHRS3 DHRS9 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GRK1 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F HSD17B1 HSD17B6 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 METAP1 METAP2 MYO7A NAPEPLD NMT1 NMT2 OPN1LW OPN1MW OPN1SW PDE6A PDE6B PDE6G PLB1 PNLIP PPEF1 PRKCA PRKCQ RBP1 RBP2 RBP3 RBP4 RCVRN RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RGS9 RGS9BP RHO RLBP1 RPE65 SAG SDC1 SDC2 SDC3 SDC4 SDR9C7 SLC24A1 STRA6 TTR +Diseases of glycosylation Reactome Pathway ABCC5 ACAN AGRN ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CALR CANX CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CMAS CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 CTSA DAD1 DCN DDOST DHDDS DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 DSE DSEL EDEM1 EDEM2 EDEM3 EXT1 EXT2 FMOD FUT8 GANAB GFPT1 GFPT2 GLB1 GLB1L GLCE GMPPA GMPPB GNE GNPNAT1 GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LMAN1 LUM LYVE1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MVD NAGLU NANP NANS NCAN NDST1 NDST2 NDST3 NDST4 NEU1 NEU2 NEU3 NEU4 NPL OGN OMD PAPSS1 PAPSS2 PDIA3 PGM3 PMM1 PMM2 PREB PRELP PRKCSH RFT1 RPN1 RPN2 SAR1B SDC1 SDC2 SDC3 SDC4 SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SGSH SLC17A5 SLC26A1 SLC26A2 SLC35A1 SLC35B2 SLC35B3 SLC35D2 SLC9A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STAB2 STT3A TUSC3 UAP1 UGGT1 UGGT2 UST VCAN +Disinhibition of SNARE formation Reactome Pathway PRKCA PRKCB PRKCG STX4 STXBP3 +Displacement of DNA glycosylase by APE1 Reactome Pathway APEX1 CCNO MBD4 MPG MUTYH NTHL1 OGG1 SMUG1 TDG UNG +Dissolution of Fibrin Clot Reactome Pathway ANXA2 HRG PLAT PLAU PLAUR PLG S100A10 SERPINB2 SERPINB6 SERPINB8 SERPINE1 SERPINE2 SERPINF2 +Dopamine Neurotransmitter Release Cycle Reactome Pathway BZRAP1 CPLX1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +Dopamine clearance from the synaptic cleft Reactome Pathway COMT MAOA SLC6A3 +Dopamine receptors Reactome Pathway DRD1 DRD2 DRD3 DRD4 DRD5 +Double-Strand Break Repair Reactome Pathway APEX1 ATM BRCA1 BRCA2 BRIP1 H2AFX LIG1 LIG4 MDC1 MRE11A NBN PRKDC RAD50 RAD51 RAD52 RPA1 RPA2 RPA3 TDP1 TP53BP1 XRCC4 XRCC5 XRCC6 +Downregulation of ERBB2:ERBB3 signaling Reactome Pathway AKT1 AKT2 AKT3 ERBB2 ERBB3 NRG1 NRG2 RNF41 RPS27A UBA52 UBB UBC USP8 +Downregulation of ERBB4 signaling Reactome Pathway ERBB4 ITCH NEDD4 RPS27A UBA52 UBB UBC WWP1 +Downregulation of SMAD2/3:SMAD4 transcriptional activity Reactome Pathway HDAC1 NCOR1 NCOR2 NEDD4L PARP1 PPM1A RNF111 RPS27A SKI SKIL SMAD2 SMAD3 SMAD4 SMURF2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 USP9X +Downregulation of TGF-beta receptor signaling Reactome Pathway BAMBI MTMR4 NEDD4L PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA52 UBB UBC UCHL5 USP15 XPO1 ZFYVE9 +Downstream TCR signaling Reactome Pathway BCL10 CARD11 CD247 CD3D CD3E CD3G CD4 CHUK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IKBKB IKBKG INPP5D LCK MALT1 MAP3K7 NFKB1 NFKBIA PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKCQ PTEN RELA RIPK2 TAB2 TCRA TCRB TRAC TRAF6 TRAT1 TRBC1 TRBV12-3 UBE2N UBE2V1 +Downstream signal transduction Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCAR1 BTC CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 CRK CRKL EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GRB7 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NCK1 NCK2 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RAPGEF1 RASA1 RICTOR RPS6KB2 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 VAV1 YWHAB +Downstream signaling events of B Cell Receptor (BCR) Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCL10 BTC BTRC CARD11 CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 CUL1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FBXW11 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HRAS IKBKB IKBKG IRS1 IRS2 KIT KITLG KL KLB KRAS LCK MALT1 MAP3K7 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NFKB1 NFKBIA NFKBIB NFKBIE NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PTPN11 RASGRP1 RASGRP3 REL RELA RICTOR RPS27A RPS6KB2 SKP1 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 UBA52 UBB UBC VAV1 +Downstream signaling of activated FGFR Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RICTOR RPS6KB2 SHC1 SOS1 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 VAV1 YWHAB +Dual incision reaction in GG-NER Reactome Pathway CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 RAD23B RPA1 RPA2 RPA3 XPA XPC +Dual incision reaction in TC-NER Reactome Pathway CCNH CDK7 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TCEA1 XAB2 +E2F mediated regulation of DNA replication Reactome Pathway CCNA1 CCNB1 CCNE1 CDC25A CDC45 CDC6 CDK1 CDT1 DHFR E2F1 FBXO5 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 RRM2 TFDP1 TK2 TYMS +E2F-enabled inhibition of pre-replication complex formation Reactome Pathway CCNB1 CDC25A CDK1 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +ECM proteoglycans Reactome Pathway ACAN AGRN ASPN BCAN BGN COL9A1 COL9A2 COL9A3 COMP DAG1 DCN DMP1 DSPP FMOD HAPLN1 IBSP ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMC1 LRP4 LUM MATN1 MATN3 MATN4 MUSK NCAM1 NCAN PTPRS SERPINE1 SPARC TGFB1 TGFB2 TGFB3 TNC TNN TNR TNXB VCAN VTN +EGFR Transactivation by Gastrin Reactome Pathway EGFR GRB2 HBEGF HRAS KRAS MMP3 NRAS PRKCA SOS1 +EGFR downregulation Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 CBL CDC42 CLTA EGF EGFR EPN1 EPS15 EPS15L1 GRB2 HGS RPS27A SH3GL2 SH3KBP1 SPRY1 SPRY2 STAM STAM2 UBA52 UBB UBC +EGFR interacts with phospholipase C-gamma Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 EGF EGFR ITPR1 ITPR2 ITPR3 PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +EPH-Ephrin signaling Reactome Pathway ACTB ACTG1 ACTR2 ACTR3 ADAM10 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGEF28 ARHGEF7 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CFL1 CLTA CLTB CLTC CLTCL1 DNM1 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GIT1 GRIN1 GRIN2B HRAS HSP90AA1 ITSN1 KALRN KDR LIMK1 LIMK2 LYN MMP2 MMP9 MYH10 MYH11 MYH14 MYH9 MYL12A MYL12B MYL6 MYL9 NCK2 NCSTN NGEF PAK1 PAK2 PAK3 PSEN2 PSENEN PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SDC2 SDCBP SHB SRC TIAM1 VAV2 VAV3 VEGFA WASL YES1 +EPH-ephrin mediated repulsion of cells Reactome Pathway ADAM10 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B CLTA CLTB CLTC CLTCL1 DNM1 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN LYN MMP2 MMP9 NCSTN PSEN2 PSENEN RAC1 SRC TIAM1 VAV2 VAV3 YES1 +EPHA-mediated growth cone collapse Reactome Pathway EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 FYN HSP90AA1 KDR LYN MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NGEF PTK2 RHOA ROCK1 ROCK2 SHB SRC VEGFA YES1 +EPHB-mediated forward signaling Reactome Pathway ACTB ACTG1 ACTR2 ACTR3 ARHGEF28 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CFL1 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GRIN1 GRIN2B HRAS ITSN1 KALRN LIMK1 LIMK2 LYN PAK1 PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SDC2 SRC TIAM1 WASL YES1 +ER Quality Control Compartment (ERQC) Reactome Pathway EDEM1 EDEM2 EDEM3 MAN1B1 UGGT1 UGGT2 +ER to Golgi Transport Reactome Pathway PREB SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A +ER-Phagosome pathway Reactome Pathway B2M CALR HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SEC61A1 SEC61A2 SEC61B SEC61G TAP1 TAP2 TAPBP UBA52 UBB UBC +ERK activation Reactome Pathway CDK1 IL6 IL6R IL6ST JAK1 JAK2 MAP2K1 MAP2K2 MAPK1 MAPK3 PTPN11 TYK2 +ERK/MAPK targets Reactome Pathway DUSP3 DUSP4 DUSP6 DUSP7 ELK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +ERK1 activation Reactome Pathway CDK1 IL6 IL6R IL6ST JAK1 JAK2 MAP2K1 MAPK3 PTPN11 TYK2 +ERK2 activation Reactome Pathway IL6 IL6R IL6ST JAK1 JAK2 MAP2K2 MAPK1 PTPN11 TYK2 +ERKs are inactivated Reactome Pathway DUSP3 DUSP4 DUSP6 DUSP7 MAPK1 MAPK3 MAPK7 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D +Early Phase of HIV Life Cycle Reactome Pathway BANF1 CCR5 CD4 CXCR4 FEN1 HMGA1 KPNA1 LIG1 LIG4 PPIA PSIP1 XRCC4 XRCC5 XRCC6 env gag gag-pol nef rev vif vpr vpu +Effects of PIP2 hydrolysis Reactome Pathway DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ ITPR1 ITPR2 ITPR3 MGLL PRKCD PRKCE PRKCH PRKCQ RASGRP1 RASGRP2 TRPC3 TRPC6 TRPC7 +Eicosanoid ligand-binding receptors Reactome Pathway CYSLTR1 CYSLTR2 GPR17 LTB4R LTB4R2 OXER1 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R +Eicosanoids Reactome Pathway CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP8B1 PTGIS TBXAS1 +Elastic fibre formation Reactome Pathway BMP10 BMP2 BMP4 BMP7 EFEMP1 EFEMP2 ELN FBLN1 FBLN2 FBLN5 FBN1 FBN2 FBN3 FURIN GDF5 ITGA5 ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LOX LOXL1 LOXL2 LOXL3 LOXL4 LTBP1 LTBP2 LTBP3 LTBP4 MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 TGFB1 TGFB2 TGFB3 VTN +Electric Transmission Across Gap Junctions Reactome Pathway GJA10 GJC1 GJD2 PANX1 PANX2 +Electron transport from NADPH to Ferredoxin Reactome Pathway FDX1 FDX1L FDXR +Elevation of cytosolic Ca2+ levels Reactome Pathway ITPR1 ITPR2 ITPR3 ORAI1 P2RX1 STIM1 TRPC3 TRPC6 TRPC7 +Elongation arrest and recovery Reactome Pathway CCNT1 CCNT2 CDK9 CTDP1 ELL GTF2F1 GTF2F2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +Endogenous sterols Reactome Pathway CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1B1 CYP21A2 CYP27A1 CYP39A1 CYP46A1 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR NCOA1 NCOA2 NR1H4 POMC PTGIS RXRA +Endosomal Sorting Complex Required For Transport (ESCRT) Reactome Pathway CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 HGS RPS27A SNF8 STAM STAM2 TSG101 UBA52 UBB UBC VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 +Endosomal/Vacuolar pathway Reactome Pathway B2M CTSL CTSS CTSV HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G LNPEP +Energy dependent regulation of mTOR by LKB1-AMPK Reactome Pathway CAB39 CAB39L PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPTOR STK11 STRADA STRADB TSC1 TSC2 +Entry of Influenza Virion into Host Cell via Endocytosis Reactome Pathway CLTA HA M NA NP NS PA PB1 PB2 +Enzymatic degradation of Dopamine by monoamine oxidase Reactome Pathway COMT MAOA +Enzymatic degradation of dopamine by COMT Reactome Pathway COMT MAOA +Ephrin signaling Reactome Pathway ARHGEF7 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GIT1 MYL12A NCK2 PAK1 PAK2 PAK3 RAC1 SDCBP SRC +Epigenetic regulation of gene expression Reactome Pathway 18S rRNA, 5.8S rRNA, 28S rRNA 28S rRNA AEBP2 ARID4B BAZ2A CCNH CD3EAP CDK7 DNMT1 DNMT3A DNMT3B DNMT3L EED ERCC2 ERCC3 EZH2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB JARID2 MBD2 MNAT1 MTF2 PHF1 PHF19 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RRP8 SAP130 SAP18 SAP30 SAP30BP SAP30L SIN3A SIN3B SIRT1 SMARCA5 SUDS3 SUV39H1 SUZ12 TAF1A TAF1B TAF1C TAF1D TBP TDG TET1 TET2 TET3 TTF1 TWISTNB UBTF UHRF1 ZNRD1 +Erythrocytes take up carbon dioxide and release oxygen Reactome Pathway AQP1 CA1 CA2 CA4 HBA1 HBB RHAG SLC4A1 +Erythrocytes take up oxygen and release carbon dioxide Reactome Pathway AQP1 CA1 CA2 CA4 HBA1 HBB RHAG SLC4A1 +Establishment of Sister Chromatid Cohesion Reactome Pathway CDCA5 ESCO1 ESCO2 PDS5A PDS5B RAD21 SMC1A SMC3 STAG1 STAG2 WAPAL +Estrogen biosynthesis Reactome Pathway CYP19A1 HSD17B1 +Ethanol oxidation Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 +Eukaryotic Translation Elongation Reactome Pathway EEF1A1 EEF1A1P5 EEF1A2 EEF1B2 EEF1D EEF1G EEF2 FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Eukaryotic Translation Initiation Reactome Pathway EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5B FAU PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Eukaryotic Translation Termination Reactome Pathway ETF1 FAU GSPT2 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Export of Viral Ribonucleoproteins from Nucleus Reactome Pathway AAAS HSPA1A M NP NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POM121 RAE1 RAN RANBP2 SEH1L TPR XPO1 +Extension of Telomeres Reactome Pathway APEX1 DKC1 DNA2 FEN1 LIG1 NHP2 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RUVBL1 RUVBL2 TERT WRAP53 +Extracellular matrix organization Reactome Pathway A2M ACAN ACTN1 ADAM10 ADAM15 ADAM17 ADAM8 ADAM9 ADAMTS1 ADAMTS14 ADAMTS16 ADAMTS18 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 AGRN ASPN BCAN BGN BMP1 BMP10 BMP2 BMP4 BMP7 BSG CAPN1 CAPNS1 CASK CASP3 CD151 CD44 CD47 CDH1 CEACAM1 CEACAM6 CEACAM8 CMA1 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLGALT1 COLGALT2 COMP CRTAP CTRB1 CTRB2 CTSB CTSD CTSG CTSK CTSL CTSS CTSV DAG1 DCN DDR1 DDR2 DMD DMP1 DSPP DST EFEMP1 EFEMP2 ELANE ELN F11R FBLN1 FBLN2 FBLN5 FBN1 FBN2 FBN3 FGA FGB FGF2 FGG FMOD FN1 FURIN GDF5 HAPLN1 HSPG2 IBSP ICAM1 ICAM2 ICAM3 ICAM4 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JAM2 JAM3 KDR KLK2 KLK7 KLKB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 LEPRE1 LEPREL1 LEPREL2 LOX LOXL1 LOXL2 LOXL3 LOXL4 LRP4 LTBP1 LTBP2 LTBP3 LTBP4 LUM MADCAM1 MATN1 MATN3 MATN4 MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 MUSK NCAM1 NCAN NCSTN NID1 NID2 NRXN1 NTN4 P4HB PCOLCE PCOLCE2 PDGFA PDGFB PECAM1 PLEC PLG PLOD1 PLOD2 PLOD3 PPIB PRKCA PRSS1 PRSS2 PSEN1 PTPRS SDC1 SDC2 SDC3 SDC4 SERPINE1 SERPINH1 SPARC SPP1 TGFB1 TGFB2 TGFB3 THBS1 TIMP1 TIMP2 TLL1 TLL2 TNC TNN TNR TNXB TPSAB1 TRAPPC4 TTR VCAM1 VCAN VTN +Extrinsic Pathway Reactome Pathway ADAM17 APPL1 CASP10 CASP3 CASP8 CASP9 CFLAR DAPK1 DAPK2 DAPK3 DCC FADD FAS FASLG MAGED1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFSF10 UNC5A UNC5B +FBXW7 Mutants and NOTCH1 in Cancer Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +FCERI mediated Ca+2 mobilization Reactome Pathway BTK CALM1 GRAP2 GRB2 IGHE IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 ITK ITPR1 ITPR2 ITPR3 LAT LCP2 LYN NFATC1 NFATC2 NFATC3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 SHC1 SOS1 SYK TEC TXK VAV1 VAV2 VAV3 +FCERI mediated MAPK activation Reactome Pathway CDK1 FOS GRAP2 GRB2 HRAS IGHE IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IL6 IL6R IL6ST JAK1 JAK2 JUN KRAS LAT LCP2 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NRAS PAK1 PAK2 PAK3 PLCG1 PLCG2 PTPN11 RAC1 RAF1 SHC1 SOS1 SYK TYK2 VAV1 VAV2 VAV3 YWHAB +FCERI mediated NF-kB activation Reactome Pathway BCL10 CARD11 CHUK IGHE IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IKBKB IKBKG LYN MALT1 MAP3K7 NFKB1 NFKBIA PDPK1 PRKCQ RASGRP1 RASGRP2 RASGRP4 RELA TAB1 TAB2 TAB3 TRAF6 UBE2N UBE2V1 +FCGR activation Reactome Pathway CD247 CD3G FCGR1A FCGR2A FCGR3A FGR FYN HCK IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 LYN SRC SYK YES1 +FGFR ligand binding and activation Reactome Pathway FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 KL KLB +FGFR1 ligand binding and activation Reactome Pathway FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 +FGFR1b ligand binding and activation Reactome Pathway FGF1 FGF10 FGF2 FGF22 FGF3 +FGFR1c and Klotho ligand binding and activation Reactome Pathway FGF23 FGFR1 KL +FGFR1c ligand binding and activation Reactome Pathway FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 +FGFR2 ligand binding and activation Reactome Pathway FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 +FGFR2b ligand binding and activation Reactome Pathway FGF1 FGF10 FGF22 FGF3 FGF7 FGFR2 +FGFR2c ligand binding and activation Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR2 +FGFR3 ligand binding and activation Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 +FGFR3b ligand binding and activation Reactome Pathway FGF1 FGF17 FGF18 FGF20 FGF8 FGF9 FGFR3 +FGFR3c ligand binding and activation Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 +FGFR4 ligand binding and activation Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 +FMO oxidises nucleophiles Reactome Pathway FMO1 FMO2 FMO3 +FRS2-mediated cascade Reactome Pathway CDK1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 FRS3 GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SOS1 TYK2 YWHAB +Facilitative Na+-independent glucose transporters Reactome Pathway SLC2A10 SLC2A11 SLC2A12 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 +Factors involved in megakaryocyte development and platelet production Reactome Pathway ABL1 AK3 AKAP1 AKAP10 CABLES1 CABLES2 CAPZA1 CAPZA2 CAPZB CBX5 CDC42 CDK2 CDK5 CENPE CREBBP DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 EHD1 EHD2 EHD3 EP300 GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 H3F3A HBB HBD HBE1 HBG1 HBG2 HDAC1 HDAC2 HIST1H3A HIST2H3A HMG20B IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IRF1 IRF2 IRF3 IRF7 ITPK1 JAK2 JMJD1C KDM1A KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 LRRC16A MAFF MAFG MAFK MFN1 MFN2 MYB NFE2 PHF21A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB5A RAC1 RACGAP1 RAD51B RAD51C RCOR1 SH2B1 SH2B2 SH2B3 SIN3A TP53 VPS45 WEE1 ZFPM1 ZFPM2 ZFYVE20 +Fanconi Anemia pathway Reactome Pathway ATM ATR BRCA1 BRCA2 FAAP100 FAAP24 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM PALB2 RPS27A UBA52 UBB UBC UBE2T USP1 ZBTB32 +FasL/ CD95L signaling Reactome Pathway CASP10 CASP8 FADD FAS FASLG +Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Reactome Pathway FFAR1 GNA11 GNA14 GNA15 GNAQ PLCB1 PLCB2 PLCB3 +Fatty Acyl-CoA Biosynthesis Reactome Pathway ACACA ACLY ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 FASN HSD17B12 HSD17B3 SLC25A1 TECR TECRL +Fatty acid, triacylglycerol, and ketone body metabolism Reactome Pathway ABCA1 ABCB4 ACACA ACACB ACADL ACADM ACADS ACADVL ACAT1 ACLY ACOX1 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 AGT ALAS1 ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARNTL BDH1 CARM1 CCNC CD36 CDK19 CDK8 CHD9 CLOCK CPT1A CPT1B CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 DECR1 DGAT1 DGAT2 ECHS1 ECI1 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 EP300 ESRRA FABP1 FADS1 FASN FDFT1 FHL2 G0S2 GK GK2 GK3P GLIPR1 GPAM GPAT2 GPD1 GPD1L GPD2 GRHL1 HADH HADHA HADHB HDAC3 HELZ2 HMGCL HMGCR HMGCS1 HMGCS2 HSD17B12 HSD17B3 LCLAT1 LPCAT1 LPCAT4 LPIN1 LPIN2 LPIN3 MCEE ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MMAA MUT NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NFYA NFYB NFYC NPAS2 NR1D1 NR1H4 NRF1 OXCT1 PCCA PCCB PEX11A PLIN2 PPARA PPARD PPARG PPARGC1A PPARGC1B PRKAA2 PRKAB2 PRKAG2 RGL1 RORA RXRA SIN3A SIN3B SLC25A1 SLC25A20 SLC27A1 SMARCD3 SP1 SREBF1 SREBF2 SULT2A1 TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TECR TECRL TGS1 TIAM2 TNFRSF21 TRIB3 TXNRD1 UGT1A9 WWTR1 YAP1 +Fatty acids Reactome Pathway CYP2A13 CYP2A7 CYP2B6 CYP2D6 CYP2F1 CYP2J2 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 +Fc epsilon receptor (FCERI) signaling Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCL10 BTC BTK CALM1 CARD11 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FCER1A FCER1G FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOS FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GAB2 GRAP2 GRB2 GSK3A GSK3B HBEGF HRAS IGHE IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IKBKB IKBKG IL6 IL6R IL6ST IRS1 IRS2 ITK ITPR1 ITPR2 ITPR3 JAK1 JAK2 JUN KIT KITLG KL KLB KRAS LAT LAT2 LCK LCP2 LYN MALT1 MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MS4A2 MTOR NFATC1 NFATC2 NFATC3 NFKB1 NFKBIA NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAK1 PAK2 PAK3 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 PRKCQ PTEN PTPN11 RAC1 RAF1 RASGRP1 RASGRP2 RASGRP4 RELA RICTOR RPS6KB2 SHC1 SOS1 SYK TAB1 TAB2 TAB3 TEC THEM4 TNRC6A TNRC6B TNRC6C TRAF6 TRAT1 TRIB3 TSC2 TXK TYK2 UBE2N UBE2V1 VAV1 VAV2 VAV3 YWHAB +Fcgamma receptor (FCGR) dependent phagocytosis Reactome Pathway ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CFL1 CRK CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2A FCGR3A FGR FYN GRB2 HCK HSP90AA1 HSP90AB1 IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 ITPR1 ITPR2 ITPR3 LIMK1 LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKIPSD PAK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PPAPDC1A PPAPDC1B PRKCD PRKCE PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YES1 +Fertilization Reactome Pathway ACR ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG CD9 HVCN1 IZUMO1 IZUMO2 IZUMO3 IZUMO4 KCNU1 OVGP1 SPAM1 ZP1 ZP2 ZP3 ZP4 +Fibronectin matrix formation Reactome Pathway CEACAM1 CEACAM6 CEACAM8 FN1 ITGA5 ITGB1 +Ficolins bind to repetitive carbohydrate structures on the target cell surface Reactome Pathway FCN1 FCN2 FCN3 MASP1 MASP2 +Folding of actin by CCT/TriC Reactome Pathway ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 TCP1 +Formation of ATP by chemiosmotic coupling Reactome Pathway ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP5S MT-ATP6 MT-ATP8 +Formation of Fibrin Clot (Clotting Cascade) Reactome Pathway A2M C1QBP CD177 F10 F11 F12 F13A1 F13B F2 F2R F3 F5 F7 F8 F9 FGA FGB FGG GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PF4 PF4V1 PRCP PROC PROCR PROS1 PRTN3 SERPINA5 SERPINC1 SERPIND1 SERPINE2 SERPING1 TFPI THBD VWF +Formation of HIV elongation complex in the absence of HIV Tat Reactome Pathway CCNH CCNT1 CCNT2 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +Formation of HIV-1 elongation complex containing HIV-1 Tat Reactome Pathway CCNH CCNT1 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 tat +Formation of RNA Pol II elongation complex Reactome Pathway CCNH CCNT1 CCNT2 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +Formation of Senescence-Associated Heterochromatin Foci (SAHF) Reactome Pathway ASF1A CABIN1 CDKN1A EP400 H1F0 HIRA HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGA1 HMGA2 LMNB1 RB1 TP53 UBN1 +Formation of a pool of free 40S subunits Reactome Pathway EIF1AX EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Formation of annular gap junctions Reactome Pathway AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 +Formation of apoptosome Reactome Pathway APAF1 CASP9 CYCS +Formation of editosomes by ADAR proteins Reactome Pathway ADAR ADARB1 +Formation of incision complex in GG-NER Reactome Pathway CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 RAD23B RPA1 RPA2 RPA3 XPA XPC +Formation of the Early Elongation Complex Reactome Pathway CCNH CDK7 CTDP1 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT4H1 SUPT5H +Formation of the Editosome Reactome Pathway A1CF APOBEC1 +Formation of the HIV-1 Early Elongation Complex Reactome Pathway CCNH CDK7 CTDP1 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT4H1 SUPT5H +Formation of the active cofactor, UDP-glucuronate Reactome Pathway SLC35D1 UGDH UGP2 +Formation of the ternary complex, and subsequently, the 43S complex Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K FAU RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA +Formation of transcription-coupled NER (TC-NER) repair complex Reactome Pathway CCNH CDK7 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TCEA1 XAB2 +Formation of tubulin folding intermediates by CCT/TriC Reactome Pathway CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 +Formyl peptide receptors bind formyl peptides and many other ligands Reactome Pathway ANXA1 APP CCL23 FPR1 FPR2 FPR3 HEBP1 MT-RNR2 SAA1 +Free fatty acid receptors Reactome Pathway FFAR1 FFAR2 FFAR3 FFAR4 GPR31 +Free fatty acids regulate insulin secretion Reactome Pathway FFAR1 GNA11 GNA14 GNA15 GNAQ PLCB1 PLCB2 PLCB3 +Frs2-mediated activation Reactome Pathway BRAF CDK1 CRKL FRS2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 PLCG1 PTPN11 RAF1 RAP1A RAPGEF1 TYK2 YWHAB +Fructose catabolism Reactome Pathway ALDOB KHK +Fusion and Uncoating of the Influenza Virion Reactome Pathway HA M NA NP NS PA PB1 PB2 +Fusion of the Influenza Virion to the Host Cell Endosome Reactome Pathway HA M NA NP NS PA PB1 PB2 +G alpha (12/13) signalling events Reactome Pathway ABR ADRA1A ADRA1B ADRA1D AKAP13 ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 CDC42 ECT2 FGD1 FGD2 FGD3 FGD4 GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITSN1 KALRN MCF2 MCF2L NET1 NGEF OBSCN PIK3CA PIK3R1 PIK3R2 PIK3R3 PLEKHG2 PLEKHG5 PLXNB1 RAC1 RAC2 RASGRF2 RHOA RHOB RHOC RHOG ROCK1 ROCK2 SOS1 SOS2 TBXA2R TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 +G alpha (i) signalling events Reactome Pathway ACKR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA1 ADORA3 ADRA2A ADRA2B ADRA2C AGT AGTR2 ANXA1 APLN APLNR APP BDKRB1 BDKRB2 C3 C3AR1 C5 C5AR1 CASR CCL16 CCL19 CCL20 CCL21 CCL23 CCL25 CCL27 CCL28 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CHRM2 CHRM4 CNR1 CNR2 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DRD2 DRD3 DRD4 FPR1 FPR2 FPR3 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GNAI1 GNAI2 GNAI3 GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPER1 GPR17 GPR18 GPR55 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 HCAR1 HCAR2 HCAR3 HEBP1 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR5A INSL5 KNG1 LPAR1 LPAR2 LPAR3 LPAR5 MCHR1 MCHR2 MT-RNR2 MTNR1A MTNR1B NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPW NPY NPY1R NPY2R NPY4R NPY5R OPN1LW OPN1MW OPN1SW OPN3 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 P2RY12 P2RY13 P2RY14 P2RY4 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PTGDR2 PTGER3 PYY RGR RGS1 RGS10 RGS11 RGS12 RGS14 RGS18 RGS19 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RLN3 RRH RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 +G alpha (q) signalling events Reactome Pathway ADRA1A ADRA1B ADRA1D ADRBK1 AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 CASR CCK CCKAR CCKBR CCL23 CHRM1 CHRM3 CHRM5 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPR132 GPR17 GPR4 GPR65 GPR68 GPRC6A GRK5 GRM1 GRM5 GRP GRPR HCRT HCRTR1 HCRTR2 HRH1 HTR2A HTR2B HTR2C ITPR1 ITPR2 ITPR3 KALRN KISS1 KISS1R KNG1 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MCHR1 MCHR2 MGLL MLN MLNR MT-RNR2 NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PRKCD PRKCE PRKCH PRKCQ PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RASGRP1 RASGRP2 RGS18 RGS19 RGS2 RGS21 SAA1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO TRPC3 TRPC6 TRPC7 UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 +G alpha (s) signalling events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA2A ADORA2B ADRB1 ADRB2 ADRB3 AVP AVPR2 CALCA CALCB CALCR CALCRL CGA CRH CRHR1 CRHR2 DRD1 DRD5 FSHB FSHR GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPBAR1 HRH2 HTR4 HTR6 HTR7 IAPP INSL3 LHB LHCGR MC1R MC2R MC3R MC4R MC5R NPS NPSR1 P2RY11 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B POMC PTGDR PTGER2 PTGER4 PTGIR PTH PTH1R PTH2 PTH2R PTHLH RAMP1 RAMP2 RAMP3 RLN2 RLN3 RXFP1 RXFP2 SCT SCTR TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TSHB TSHR VIP VIPR1 VIPR2 +G alpha (z) signalling events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A ADRA2B ADRA2C GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ RGS17 RGS19 RGS20 RGS4 +G beta:gamma signalling through PI3Kgamma Reactome Pathway AKT1 AKT2 AKT3 CSF2 CSF2RA CSF2RB GAB2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA JAK1 JAK2 JAK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 RHOA SHC1 +G beta:gamma signalling through PLC beta Reactome Pathway GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PLCB1 PLCB2 PLCB3 +G protein gated Potassium channels Reactome Pathway GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +G-protein activation Reactome Pathway GNAI1 GNAI2 GNAI3 GNAO1 GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 OPRM1 PDYN POMC +G-protein beta:gamma signalling Reactome Pathway AKT1 AKT2 AKT3 CSF2 CSF2RA CSF2RB GAB2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA JAK1 JAK2 JAK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 RHOA SHC1 +G-protein mediated events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAT1 GNAT2 GNAT3 GNAZ ITPR1 ITPR2 ITPR3 MAPK1 PDE1A PDE1B PDE1C PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +G0 and Early G1 Reactome Pathway CCNA1 CCNA2 CCNE1 CCNE2 CDC25A CDC6 CDK1 CDK2 DYRK1A E2F1 E2F4 E2F5 HDAC1 LIN37 LIN52 LIN54 LIN9 MYBL2 PCNA RBBP4 RBL1 RBL2 TFDP1 TFDP2 TOP2A +G1 Phase Reactome Pathway CCND1 CCND2 CCND3 CCNH CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CKS1B CUL1 E2F1 E2F2 E2F3 E2F4 E2F5 MNAT1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B RB1 RBL1 RBL2 RPS27A SKP1 SKP2 TFDP1 TFDP2 UBA52 UBB UBC +G1/S DNA Damage Checkpoints Reactome Pathway ATM CCNE1 CCNE2 CDC25A CDK2 CDKN1A CDKN1B CHEK1 CHEK2 MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RPS27A TP53 UBA52 UBB UBC +G1/S Transition Reactome Pathway CCNA1 CCNA2 CCNB1 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DBF4 DHFR E2F1 FBXO5 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 POLA1 POLA2 POLE POLE2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RB1 RPA1 RPA2 RPA3 RPA4 RPS27A RRM2 SKP1 SKP2 TFDP1 TK2 TYMS UBA52 UBB UBC WEE1 +G1/S-Specific Transcription Reactome Pathway CCNA1 CCNE1 CDC25A CDC45 CDC6 CDK1 CDT1 DHFR E2F1 FBXO5 ORC1 PCNA POLA1 RRM2 TFDP1 TK2 TYMS +G2 Phase Reactome Pathway CCNA1 CCNA2 CDK2 E2F1 E2F3 +G2/M Checkpoints Reactome Pathway ATM ATR ATRIP CCNB1 CCNB2 CDC25A CDC25C CDC45 CDC6 CDC7 CDK1 CDK2 CHEK1 CHEK2 CLSPN DBF4 HUS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PKMYT1 RAD1 RAD17 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 WEE1 +G2/M DNA damage checkpoint Reactome Pathway ATM ATR ATRIP CCNB1 CDC25C CDK1 CHEK1 CHEK2 WEE1 +G2/M DNA replication checkpoint Reactome Pathway CCNB1 CCNB2 CDK1 PKMYT1 WEE1 +G2/M Transition Reactome Pathway ACTR1A AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNA1 CCNA2 CCNB1 CCNB2 CCNH CCP110 CDC25A CDC25B CDC25C CDK1 CDK11A CDK11B CDK2 CDK5RAP2 CDK7 CENPF CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 EP300 FBXW11 FGFR1OP FOXM1 HAUS2 HSP90AA1 LIN37 LIN52 LIN54 LIN9 MAPRE1 MNAT1 MYBL2 NDE1 NEDD1 NEK2 NINL NUMA1 ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PKMYT1 PLK1 PLK4 PPP1CB PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PRKACA PRKAR2B RAB8A RBBP4 RPS27A SDCCAG8 SFI1 SKP1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UBA52 UBB UBC WEE1 XPO1 YWHAE YWHAG +GAB1 signalosome Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 CSK EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PAG1 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 PXN RICTOR RPS6KB2 SRC THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +GABA A (rho) receptor activation Reactome Pathway GABRR1 GABRR2 GABRR3 +GABA A receptor activation Reactome Pathway ARHGEF9 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ +GABA B receptor activation Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GABBR1 GABBR2 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +GABA receptor activation Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ARHGEF9 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +GABA synthesis Reactome Pathway GAD1 GAD2 +GABA synthesis, release, reuptake and degradation Reactome Pathway ABAT ALDH5A1 CPLX1 DNAJC5 GAD1 GAD2 HSPA8 RAB3A RIMS1 SLC32A1 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SNAP25 STX1A STXBP1 SYT1 VAMP2 +GLI proteins bind promoters of Hh responsive genes to promote transcription Reactome Pathway BOC GLI1 GLI2 GLI3 HHIP PTCH1 PTCH2 +GLI3 is processed to GLI3R by the proteasome Reactome Pathway BTRC CSNK1A1 CUL1 GLI3 GSK3B PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 SUFU UBA52 UBB UBC +GP1b-IX-V activation signalling Reactome Pathway FLNA GP1BA GP1BB GP5 GP9 PIK3R1 RAF1 SRC VWF YWHAZ +GPCR downstream signaling Reactome Pathway ABR ACKR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 AGT AGTR1 AGTR2 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLN APLNR APP ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CALCA CALCB CALCR CALCRL CASR CCK CCKAR CCKBR CCL16 CCL19 CCL20 CCL21 CCL23 CCL25 CCL27 CCL28 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CDC42 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CRH CRHR1 CRHR2 CSF2 CSF2RA CSF2RB CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DRD1 DRD2 DRD3 DRD4 DRD5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FGD1 FGD2 FGD3 FGD4 FPR1 FPR2 FPR3 FSHB FSHR GAB2 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR4 GPR55 GPR65 GPR68 GPRC6A GRB2 GRK5 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INSL3 INSL5 ITPR1 ITPR2 ITPR3 ITSN1 JAK1 JAK2 JAK3 KALRN KISS1 KISS1R KNG1 LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCF2 MCF2L MCHR1 MCHR2 MGLL MLN MLNR MT-RNR2 MTNR1A MTNR1B NET1 NGEF NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OBSCN OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AC1P OR10AD1 OR10AG1 OR10C1 OR10D3 OR10D4P OR10G2 OR10G3 OR10G4 OR10G6 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J4 OR10J5 OR10J6P OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR11H1 OR11H2 OR11H4 OR11H6 OR11H7 OR11L1 OR12D2 OR12D3 OR13A1 OR13C2 OR13C3 OR13C4 OR13C5 OR13C8 OR13C9 OR13D1 OR13F1 OR13G1 OR13H1 OR13J1 OR14A16 OR14A2 OR14C36 OR14I1 OR14J1 OR14K1 OR14L1P OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1E3 OR1F1 OR1F12 OR1F2P OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1P1 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AG2 OR2AJ1 OR2AK2 OR2AP1 OR2AT4 OR2B11 OR2B2 OR2B3 OR2B6 OR2B8P OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2H2 OR2I1P OR2J1 OR2J2 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L5 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2T6 OR2T7 OR2T8 OR2V1 OR2V2 OR2W1 OR2W3 OR2W5 OR2W6P OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A4P OR4A5 OR4A8P OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C45 OR4C46 OR4C5 OR4C6 OR4D1 OR4D10 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E1 OR4E2 OR4F15 OR4F17 OR4F21 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K3 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N4 OR4N5 OR4P4 OR4Q2 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F1 OR51F2 OR51G1 OR51G2 OR51H1P OR51I1 OR51I2 OR51J1 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A4 OR52A5 OR52B2 OR52B4 OR52B6 OR52D1 OR52E1 OR52E2 OR52E4 OR52E5 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52L2P OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52P1P OR52R1 OR52W1 OR52Z1 OR56A1 OR56A3 OR56A4 OR56A5 OR56B1 OR56B2P OR56B4 OR5A1 OR5A2 OR5AC1 OR5AC2 OR5AK2 OR5AK3P OR5AL1 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B21 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5G3 OR5H1 OR5H14 OR5H15 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5K3 OR5K4 OR5L1 OR5L2 OR5M1 OR5M10 OR5M11 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6C6 OR6C65 OR6C68 OR6C70 OR6C74 OR6C75 OR6C76 OR6F1 OR6J1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6P1 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A2P OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7E24 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B2 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8G1 OR8G2 OR8G5 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J2 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A1P OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLEKHG5 PLXNB1 PMCH PNOC POMC PPBP PPY PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAC1 RAC2 RAMP1 RAMP2 RAMP3 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS10 RGS11 RGS12 RGS14 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RHOA RHOB RHOC RHOG RLN2 RLN3 ROCK1 ROCK2 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHC1 SOS1 SOS2 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR UTS2 UTS2B UTS2R VAV1 VAV2 VAV3 VIP VIPR1 VIPR2 XCL1 XCL2 XCR1 +GPCR ligand binding Reactome Pathway ACKR1 ACKR2 ACKR3 ACKR4 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 ANXA1 APLN APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CASR CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD55 CD97 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CRH CRHR1 CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DHH DRD1 DRD2 DRD3 DRD4 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MT-RNR2 MTNR1A MTNR1B NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTCH1 PTCH2 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHH SMO SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TRH TRHR TSHB TSHR UTS2 UTS2B UTS2R WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 +GPVI-mediated activation cascade Reactome Pathway AKT1 AKT2 AKT3 CDC42 CSF2 CSF2RA CSF2RB FCER1G FYN GAB2 GP6 GRB2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA JAK1 JAK2 JAK3 LAT LCK LCP2 LYN PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCG2 PRKCZ RAC1 RAC2 RHOA RHOB RHOG SHC1 SYK VAV1 VAV2 VAV3 +GRB2 events in EGFR signaling Reactome Pathway CDK1 EGF EGFR GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SOS1 TYK2 YWHAB +GRB2 events in ERBB2 signaling Reactome Pathway BTC CDK1 EGF EGFR ERBB2 ERBB4 EREG GRB2 HBEGF HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS NRG1 NRG2 NRG3 NRG4 PTPN11 RAF1 SOS1 TYK2 YWHAB +GRB2:SOS provides linkage to MAPK signaling for Integrins Reactome Pathway APBB1IP FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PTK2 RAP1A RAP1B SOS1 SRC TLN1 VWF +GRB7 events in ERBB2 signaling Reactome Pathway ERBB2 ERBB3 GRB7 NRG1 NRG2 +GTP hydrolysis and joining of the 60S ribosomal subunit Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H EIF5 EIF5B FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Galactose catabolism Reactome Pathway GALE GALK1 GALT PGM1 PGM2 +Gamma carboxylation, hypusine formation and arylsulfatase activation Reactome Pathway ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK DHPS DNAJC24 DOHH DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 EEF2 EIF5A EIF5A2 F10 F2 F7 F9 FURIN GAS6 GGCX PROC PROS1 PROZ STS SUMF1 SUMF2 VKORC1 +Gamma-carboxylation of protein precursors Reactome Pathway F10 F2 F7 F9 GAS6 GGCX PROC PROS1 PROZ +Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Reactome Pathway F10 F2 F7 F9 FURIN GAS6 GGCX PROC PROS1 PROZ VKORC1 +Gap junction assembly Reactome Pathway GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 +Gap junction degradation Reactome Pathway AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 MYO6 +Gap junction trafficking Reactome Pathway AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 MYO6 +Gap junction trafficking and regulation Reactome Pathway AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 MYO6 SRC TJP1 +Gap-filling DNA repair synthesis and ligation in GG-NER Reactome Pathway APEX1 LIG1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Gap-filling DNA repair synthesis and ligation in TC-NER Reactome Pathway APEX1 LIG1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Gastrin-CREB signalling pathway via PKC and MAPK Reactome Pathway ADRA1A ADRA1B ADRA1D ADRBK1 AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 CASR CCK CCKAR CCKBR CCL23 CDK1 CHRM1 CHRM3 CHRM5 CREB1 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ EDN1 EDN2 EDN3 EDNRA EDNRB EGFR F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPR132 GPR17 GPR4 GPR65 GPR68 GPRC6A GRB2 GRK5 GRM1 GRM5 GRP GRPR HBEGF HCRT HCRTR1 HCRTR2 HRAS HRH1 HTR2A HTR2B HTR2C IL6 IL6R IL6ST ITPR1 ITPR2 ITPR3 JAK1 JAK2 KALRN KISS1 KISS1R KNG1 KRAS LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK7 MCHR1 MCHR2 MGLL MLN MLNR MMP3 MT-RNR2 NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NRAS NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PRKCA PRKCD PRKCE PRKCH PRKCQ PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGER1 PTGFR PTPN11 QRFP QRFPR RAF1 RASGRP1 RASGRP2 RGS18 RGS19 RGS2 RGS21 RPS6KA1 RPS6KA2 RPS6KA3 SAA1 SOS1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TYK2 UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 YWHAB +Gene Expression Reactome Pathway 18S rRNA, 5.8S rRNA, 28S rRNA 28S rRNA 7SL RNA (ENSG00000222619) 7SL RNA (ENSG00000222639) A1CF AAAS AARS AARS2 ACTB ADAR ADARB1 AEBP2 AGO1 AGO2 AGO3 AGO4 AIMP1 AIMP2 AKT1 ALYREF ANP32A APOBEC1 AR ARID4B ASZ1 BAZ2A BCAS2 BDP1 BRF1 BRF2 CARM1 CARS CARS2 CASC3 CBX3 CCAR1 CCNC CCNH CCNT1 CCNT2 CD2BP2 CD3EAP CD44 CDC40 CDC5L CDK7 CDK8 CDK9 CDKN2B CHD3 CHD4 CHD9 CLNS1A CLP1 CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CPSF1 CPSF2 CPSF3 CPSF7 CRCP CREBBP CSTF1 CSTF2 CSTF3 CTDP1 CTGF CTNNBL1 CWC15 DARS DARS2 DCP1A DCP1B DCP2 DCPS DDOST DDX20 DDX23 DDX4 DDX6 DGCR8 DHX38 DHX9 DICER1 DIS3 DNAJC8 DNMT1 DNMT3A DNMT3B DNMT3L DROSHA E2F4 E2F5 EARS2 EDC3 EDC4 EED EEF1A1 EEF1A1P5 EEF1A2 EEF1B2 EEF1D EEF1E1 EEF1G EEF2 EFTUD2 EHMT2 EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5B ELAVL1 ELL EPRS ERCC2 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRB ESRRG ETF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EZH2 FARS2 FARSA FARSB FAU FKBP6 FUS GARS GATA4 GATAD2A GATAD2B GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GSPT2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H19 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HARS HARS2 HDAC1 HDAC2 HELZ2 HENMT1 HIPK1 HIPK2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HKR1 HNF4A HNF4G HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 HSP90AA1 HSPA1A HSPA8 HSPB1 IARS IARS2 IGF2 IGF2BP1 IGF2BP2 IGF2BP3 IPO8 JARID2 JUNB KARS KAT2A KAT2B KHSRP KRBA1 KRBOX4 LARS LARS2 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAEL MAGOH MAML1 MAML2 MAML3 MAMLD1 MAPK11 MAPK14 MAPK3 MAPKAPK2 MARS MARS2 MBD2 MBD3 MED1 MED10 MED12 MED13 MED14 MED15 MED16 MED17 MED20 MED23 MED24 MED25 MED26 MED27 MED30 MED31 MED4 MED6 MED7 MED8 MEN1 METTL3 MNAT1 MOV10L1 MTA1 MTA2 MTA3 MTERF1 MTF2 MYBL1 MYC NARS NARS2 NCBP1 NCBP2 NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NEDD4L NELFA NELFB NELFCD NELFE NFIA NFIB NFIC NFIX NHP2L1 NKX2-5 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NPPA NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 NUDT21 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 PABPC1 PABPN1 PAIP1 PAN2 PAN3 PAPOLA PARN PARP1 PARS2 PATL1 PCBP1 PCBP2 PCF11 PGR PHAX PHF1 PHF19 PHF5A PIWIL1 PIWIL2 PIWIL4 PLD6 PLRG1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRMT POM121 POU2F1 PPA1 PPA2 PPARA PPARD PPARG PPM1A PPP2CA PPP2R1A PPP2R2A PRDM7 PRKCA PRKCD PRKRA PRMT5 PRPF19 PRPF4 PRPF6 PRPF8 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTBP1 PTRF QARS RAE1 RAN RANBP2 RARA RARB RARG RARS RARS2 RBBP4 RBBP7 RBL1 RBM5 RBM8A RBMX RBPJ RNF111 RNGTT RNMT RNPS1 RORA RORB RORC RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RQCD1 RRN3 RRP8 RUNX2 RXRA RXRB RXRG SAP130 SAP18 SAP30 SAP30BP SAP30L SARS SARS2 SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SEH1L SERPINE1 SET SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SIN3A SIN3B SIRT1 SKI SKIL SLBP SMAD2 SMAD3 SMAD4 SMAD7 SMARCA5 SMARCD3 SMC1A SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 SMN1 SMURF2 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN SNW1 SP1 SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRPR SRPRB SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SSB SSR1 SSR2 SSR3 SSR4 SSRP1 SUDS3 SUGP1 SUPT16H SUPT4H1 SUPT5H SUV39H1 SUZ12 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1D TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TARBP2 TARS TARS2 TBL1X TBL1XR1 TBP TBX5 TCEA1 TCEB1 TCEB2 TCEB3 TDG TDRD1 TDRD12 TDRD6 TDRD9 TDRKH TEAD1 TEAD2 TEAD3 TEAD4 TET1 TET2 TET3 TFAM TFB2M TFDP1 TFDP2 TGIF1 TGIF2 TGS1 THRA THRB TNFSF13 TNKS1BP1 TNPO1 TNRC6A TNRC6B TNRC6C TPR TRAM1 TRIM28 TRIM33 TSN TSNAX TTF1 TWISTNB TXNL4A U2AF1 U2AF2 UBA52 UBB UBC UBE2D1 UBE2D3 UBTF UHRF1 UPF1 UPF2 UPF3A UPF3B USP9X VARS VARS2 VDR WARS WARS2 WDR77 WWTR1 XPO1 XPO5 XRN1 YAP1 YARS YARS2 YBX1 YWHAB YWHAZ ZFP1 ZFP14 ZFP2 ZFP28 ZFP30 ZFP36 ZFP36L1 ZFP37 ZFP69 ZFP69B ZFP90 ZIK1 ZIM2 ZIM3 ZKSCAN1 ZKSCAN3 ZKSCAN4 ZKSCAN5 ZKSCAN7 ZKSCAN8 ZNF10 ZNF100 ZNF101 ZNF112 ZNF114 ZNF12 ZNF124 ZNF133 ZNF135 ZNF136 ZNF138 ZNF14 ZNF140 ZNF141 ZNF143 ZNF154 ZNF155 ZNF157 ZNF160 ZNF169 ZNF17 ZNF175 ZNF18 ZNF180 ZNF184 ZNF189 ZNF19 ZNF195 ZNF197 ZNF2 ZNF20 ZNF200 ZNF202 ZNF205 ZNF208 ZNF211 ZNF212 ZNF213 ZNF214 ZNF215 ZNF221 ZNF222 ZNF223 ZNF224 ZNF225 ZNF226 ZNF227 ZNF23 ZNF230 ZNF233 ZNF234 ZNF235 ZNF248 ZNF25 ZNF250 ZNF253 ZNF254 ZNF256 ZNF257 ZNF26 ZNF263 ZNF264 ZNF266 ZNF267 ZNF268 ZNF273 ZNF274 ZNF28 ZNF282 ZNF285 ZNF286A ZNF287 ZNF3 ZNF30 ZNF300 ZNF302 ZNF304 ZNF311 ZNF317 ZNF320 ZNF324 ZNF324B ZNF331 ZNF333 ZNF334 ZNF337 ZNF33A ZNF33B ZNF34 ZNF343 ZNF347 ZNF350 ZNF354A ZNF354B ZNF354C ZNF37A ZNF382 ZNF383 ZNF394 ZNF398 ZNF41 ZNF415 ZNF416 ZNF417 ZNF418 ZNF419 ZNF420 ZNF425 ZNF426 ZNF429 ZNF43 ZNF430 ZNF431 ZNF432 ZNF433 ZNF436 ZNF439 ZNF440 ZNF441 ZNF442 ZNF443 ZNF445 ZNF446 ZNF45 ZNF454 ZNF460 ZNF461 ZNF468 ZNF470 ZNF471 ZNF473 ZNF479 ZNF480 ZNF483 ZNF484 ZNF485 ZNF486 ZNF490 ZNF492 ZNF493 ZNF496 ZNF500 ZNF506 ZNF510 ZNF514 ZNF517 ZNF519 ZNF528 ZNF529 ZNF530 ZNF540 ZNF543 ZNF544 ZNF546 ZNF547 ZNF548 ZNF549 ZNF550 ZNF551 ZNF552 ZNF554 ZNF555 ZNF556 ZNF557 ZNF558 ZNF559 ZNF560 ZNF561 ZNF562 ZNF563 ZNF564 ZNF565 ZNF566 ZNF567 ZNF568 ZNF569 ZNF570 ZNF571 ZNF573 ZNF577 ZNF582 ZNF583 ZNF584 ZNF585A ZNF585B ZNF586 ZNF587 ZNF589 ZNF595 ZNF596 ZNF597 ZNF599 ZNF600 ZNF605 ZNF606 ZNF607 ZNF610 ZNF611 ZNF613 ZNF614 ZNF615 ZNF616 ZNF619 ZNF620 ZNF621 ZNF624 ZNF625 ZNF626 ZNF627 ZNF641 ZNF649 ZNF655 ZNF658 ZNF658B ZNF660 ZNF662 ZNF664 ZNF665 ZNF667 ZNF668 ZNF669 ZNF670 ZNF671 ZNF675 ZNF676 ZNF677 ZNF678 ZNF679 ZNF680 ZNF681 ZNF682 ZNF684 ZNF688 ZNF689 ZNF691 ZNF692 ZNF696 ZNF697 ZNF699 ZNF70 ZNF700 ZNF701 ZNF702P ZNF703 ZNF704 ZNF705A ZNF705D ZNF705E ZNF705F ZNF705G ZNF706 ZNF707 ZNF708 ZNF709 ZNF71 ZNF710 ZNF711 ZNF713 ZNF714 ZNF716 ZNF717 ZNF718 ZNF720 ZNF721 ZNF724P ZNF726 ZNF726P1 ZNF727P ZNF729 ZNF730 ZNF732 ZNF735P ZNF736 ZNF737 ZNF738 ZNF74 ZNF740 ZNF746 ZNF747 ZNF749 ZNF750 ZNF75A ZNF75CP ZNF75D ZNF761 ZNF764 ZNF767P ZNF77 ZNF770 ZNF771 ZNF772 ZNF773 ZNF774 ZNF775 ZNF776 ZNF777 ZNF778 ZNF782 ZNF785 ZNF786 ZNF79 ZNF790 ZNF791 ZNF792 ZNF793 ZNF799 ZNF804B ZNF839 ZNF840 ZNF860 ZNF92 ZNF99 ZNRD1 ZSCAN25 ZSCAN32 +Generation of second messenger molecules Reactome Pathway CD247 CD3D CD3E CD3G CD4 ENAH EVL FYB GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ITK LAT LCK LCP2 NCK1 PAK1 PAK2 PAK3 PLCG1 TCRA TCRB TRAC TRBC1 TRBV12-3 VASP WAS ZAP70 +Generic Transcription Pathway Reactome Pathway AR CARM1 CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CHD9 CREBBP CTGF E2F4 E2F5 ESR1 ESR2 ESRRA ESRRB ESRRG GATA4 HDAC1 HELZ2 HIPK1 HIPK2 HKR1 HNF4A HNF4G JUNB KAT2A KAT2B KRBA1 KRBOX4 MAML1 MAML2 MAML3 MAMLD1 MED1 MED10 MED12 MED13 MED14 MED15 MED16 MED17 MED20 MED23 MED24 MED25 MED26 MED27 MED30 MED31 MED4 MED6 MED7 MED8 MEN1 MYC NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NEDD4L NKX2-5 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NPPA NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 PARP1 PGR PPARA PPARD PPARG PPM1A PRDM7 RARA RARB RARG RBL1 RBPJ RNF111 RORA RORB RORC RPS27A RUNX2 RXRA RXRB RXRG SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMARCD3 SMURF2 SNW1 SP1 TBL1X TBL1XR1 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 TFDP1 TFDP2 TGIF1 TGIF2 TGS1 THRA THRB TRIM28 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 USP9X VDR WWTR1 YAP1 ZFP1 ZFP14 ZFP2 ZFP28 ZFP30 ZFP37 ZFP69 ZFP69B ZFP90 ZIK1 ZIM2 ZIM3 ZKSCAN1 ZKSCAN3 ZKSCAN4 ZKSCAN5 ZKSCAN7 ZKSCAN8 ZNF10 ZNF100 ZNF101 ZNF112 ZNF114 ZNF12 ZNF124 ZNF133 ZNF135 ZNF136 ZNF138 ZNF14 ZNF140 ZNF141 ZNF154 ZNF155 ZNF157 ZNF160 ZNF169 ZNF17 ZNF175 ZNF18 ZNF180 ZNF184 ZNF189 ZNF19 ZNF195 ZNF197 ZNF2 ZNF20 ZNF200 ZNF202 ZNF205 ZNF208 ZNF211 ZNF212 ZNF213 ZNF214 ZNF215 ZNF221 ZNF222 ZNF223 ZNF224 ZNF225 ZNF226 ZNF227 ZNF23 ZNF230 ZNF233 ZNF234 ZNF235 ZNF248 ZNF25 ZNF250 ZNF253 ZNF254 ZNF256 ZNF257 ZNF26 ZNF263 ZNF264 ZNF266 ZNF267 ZNF268 ZNF273 ZNF274 ZNF28 ZNF282 ZNF285 ZNF286A ZNF287 ZNF3 ZNF30 ZNF300 ZNF302 ZNF304 ZNF311 ZNF317 ZNF320 ZNF324 ZNF324B ZNF331 ZNF333 ZNF334 ZNF337 ZNF33A ZNF33B ZNF34 ZNF343 ZNF347 ZNF350 ZNF354A ZNF354B ZNF354C ZNF37A ZNF382 ZNF383 ZNF394 ZNF398 ZNF41 ZNF415 ZNF416 ZNF417 ZNF418 ZNF419 ZNF420 ZNF425 ZNF426 ZNF429 ZNF43 ZNF430 ZNF431 ZNF432 ZNF433 ZNF436 ZNF439 ZNF440 ZNF441 ZNF442 ZNF443 ZNF445 ZNF446 ZNF45 ZNF454 ZNF460 ZNF461 ZNF468 ZNF470 ZNF471 ZNF473 ZNF479 ZNF480 ZNF483 ZNF484 ZNF485 ZNF486 ZNF490 ZNF492 ZNF493 ZNF496 ZNF500 ZNF506 ZNF510 ZNF514 ZNF517 ZNF519 ZNF528 ZNF529 ZNF530 ZNF540 ZNF543 ZNF544 ZNF546 ZNF547 ZNF548 ZNF549 ZNF550 ZNF551 ZNF552 ZNF554 ZNF555 ZNF556 ZNF557 ZNF558 ZNF559 ZNF560 ZNF561 ZNF562 ZNF563 ZNF564 ZNF565 ZNF566 ZNF567 ZNF568 ZNF569 ZNF570 ZNF571 ZNF573 ZNF577 ZNF582 ZNF583 ZNF584 ZNF585A ZNF585B ZNF586 ZNF587 ZNF589 ZNF595 ZNF596 ZNF597 ZNF599 ZNF600 ZNF605 ZNF606 ZNF607 ZNF610 ZNF611 ZNF613 ZNF614 ZNF615 ZNF616 ZNF619 ZNF620 ZNF621 ZNF624 ZNF625 ZNF626 ZNF627 ZNF641 ZNF649 ZNF655 ZNF658 ZNF658B ZNF660 ZNF662 ZNF664 ZNF665 ZNF667 ZNF668 ZNF669 ZNF670 ZNF671 ZNF675 ZNF676 ZNF677 ZNF678 ZNF679 ZNF680 ZNF681 ZNF682 ZNF684 ZNF688 ZNF689 ZNF691 ZNF692 ZNF696 ZNF697 ZNF699 ZNF70 ZNF700 ZNF701 ZNF702P ZNF703 ZNF704 ZNF705A ZNF705D ZNF705E ZNF705F ZNF705G ZNF706 ZNF707 ZNF708 ZNF709 ZNF71 ZNF710 ZNF711 ZNF713 ZNF714 ZNF716 ZNF717 ZNF718 ZNF720 ZNF721 ZNF724P ZNF726 ZNF726P1 ZNF727P ZNF729 ZNF730 ZNF732 ZNF735P ZNF736 ZNF737 ZNF738 ZNF74 ZNF740 ZNF746 ZNF747 ZNF749 ZNF750 ZNF75A ZNF75CP ZNF75D ZNF761 ZNF764 ZNF767P ZNF77 ZNF770 ZNF771 ZNF772 ZNF773 ZNF774 ZNF775 ZNF776 ZNF777 ZNF778 ZNF782 ZNF785 ZNF786 ZNF79 ZNF790 ZNF791 ZNF792 ZNF793 ZNF799 ZNF804B ZNF839 ZNF840 ZNF860 ZNF92 ZNF99 ZSCAN25 ZSCAN32 +Global Genomic NER (GG-NER) Reactome Pathway APEX1 CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 LIG1 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RAD23B RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 XPA XPC +Glucagon signaling in metabolic regulation Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GCG GCGR GNAS GNB1 GNB2 GNB3 GNB4 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Reactome Pathway ADCY5 ADCY6 ADCY8 AKAP5 GCG GLP1R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNS3 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAP1A RAPGEF3 RAPGEF4 +Glucagon-type ligand receptors Reactome Pathway ADCYAP1 ADCYAP1R1 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 SCT SCTR +Glucocorticoid biosynthesis Reactome Pathway CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1 HSD3B1 HSD3B2 POMC +Gluconeogenesis Reactome Pathway ALDOA ALDOB ALDOC ENO1 ENO2 ENO3 FBP1 FBP2 GAPDH GAPDHS GOT1 GOT2 GPI MDH1 MDH2 PC PCK1 PCK2 PFKFB1 PGAM1 PGAM2 PGK1 PRKACA PRKACB PRKACG SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 TPI1 +Glucose metabolism Reactome Pathway AGL ALDOA ALDOB ALDOC CALM1 ENO1 ENO2 ENO3 EPM2A FBP1 FBP2 GAPDH GAPDHS GBE1 GOT1 GOT2 GPI GYG1 GYG2 GYS1 GYS2 MDH1 MDH2 NHLRC1 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PGM1 PGM2 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG PYGB PYGL PYGM RPS27A SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 TPI1 UBA52 UBB UBC UGP2 +Glucose transport Reactome Pathway AAAS G6PC G6PC2 G6PC3 GCK GCKR HK1 HK2 HK3 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC37A4 TPR +Glucuronidation Reactome Pathway SLC35D1 UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Reactome Pathway AKAP5 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CACNG2 CACNG3 CACNG4 CACNG8 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG4 EPB41L1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 MDM2 MYO6 NSF PICK1 PRKCA PRKCB PRKCG +Glutamate Neurotransmitter Release Cycle Reactome Pathway BZRAP1 CPLX1 GLS GLS2 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC17A7 SLC1A1 SLC1A6 SLC1A7 SLC38A2 SNAP25 STX1A STXBP1 SYT1 UNC13B VAMP2 +Glutathione conjugation Reactome Pathway CNDP2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MGST1 MGST2 MGST3 OPLAH +Glutathione synthesis and recycling Reactome Pathway CNDP2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GSS OPLAH +Glycerophospholipid biosynthesis Reactome Pathway ACHE AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 BCHE CDIPT CDS1 CDS2 CEPT1 CHAT CHKA CHKB CHPT1 CRLS1 DGAT1 DGAT2 EPT1 ETNK1 ETNK2 GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L HADHA HADHB LCLAT1 LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 MBOAT1 MBOAT2 MBOAT7 MGLL PCYT1A PCYT1B PCYT2 PEMT PGS1 PHOSPHO1 PISD PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLB1 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PNPLA2 PNPLA3 PNPLA8 PTDSS1 PTDSS2 PTPMT1 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 TAZ +Glycogen breakdown (glycogenolysis) Reactome Pathway AGL CALM1 GYG1 GYG2 PGM1 PGM2 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PYGB PYGL PYGM +Glycogen storage diseases Reactome Pathway AAAS ABCC5 ACAN AGL AGRN ALDOA ALDOB ALDOC AMY1A AMY1B AMY2A AMY2B ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CALM1 CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL ENO1 ENO2 ENO3 EPM2A EXT1 EXT2 FBP1 FBP2 FMOD G6PC G6PC2 G6PC3 G6PD GALE GALK1 GALT GAPDH GAPDHS GBE1 GCK GCKR GLB1 GLB1L GLCE GNS GOT1 GOT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPI GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 HAS1 HAS2 HAS3 HEXA HEXB HK1 HK2 HK3 HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA KHK LCT LUM LYVE1 MDH1 MDH2 MGAM NAGLU NCAN NDST1 NDST2 NDST3 NDST4 NHLRC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OGN OMD PAPSS1 PAPSS2 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM POM121 PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKACA PRKACB PRKACG PRPS1 PRPS1L1 PRPS2 PYGB PYGL PYGM RAE1 RANBP2 RPE RPIA RPS27A SDC1 SDC2 SDC3 SDC4 SEH1L SGSH SI SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC26A1 SLC26A2 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC35B2 SLC35B3 SLC35D2 SLC37A4 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A9 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 TALDO1 TKT TPI1 TPR TREH UBA52 UBB UBC UGP2 UST VCAN +Glycogen synthesis Reactome Pathway EPM2A GBE1 GYG1 GYG2 GYS1 GYS2 NHLRC1 PGM1 PGM2 PPP1R3C RPS27A UBA52 UBB UBC UGP2 +Glycolysis Reactome Pathway ALDOA ALDOB ALDOC ENO1 ENO2 ENO3 GAPDH GAPDHS GPI PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PKLR PKM PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D TPI1 +Glycoprotein hormones Reactome Pathway CGA CGB FSHB INHA INHBA INHBB INHBC INHBE LHB TSHB +Glycosaminoglycan metabolism Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Glycosphingolipid metabolism Reactome Pathway ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C CERK CTSA ENPP7 GALC GBA GBA2 GBA3 GLA GLB1 GLB1L GM2A HEXA HEXB NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 UGCG +Glyoxylate metabolism Reactome Pathway AGXT AGXT2 DAO GRHPR HAO1 +Golgi Associated Vesicle Biogenesis Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 CLINT1 CLTA CLTC CPD DNAJC6 DNM2 DTNBP1 FTH1 FTL GAK HIP1R HSPA8 IGF2R NAPA NECAP1 OCRL PICALM PIK3C2A PUM1 RAB5C SH3D19 SH3GL2 SNAPIN SNX2 SNX5 SNX9 SORT1 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 +Golgi Cisternae Pericentriolar Stack Reorganization Reactome Pathway BLZF1 CCNB1 CCNB2 CDK1 GOLGA2 GORASP1 GORASP2 MAPK1 MAPK3 PLK1 RAB1A RAB1B RAB2A USO1 +Golgi to ER Retrograde Transport Reactome Pathway ARCN1 ARF1 ARFGAP1 COPA COPB1 COPB2 COPE COPG1 COPZ1 GBF1 +Growth hormone receptor signaling Reactome Pathway ADAM17 CISH CSH1 GH1 GH2 GHR IRS1 IRS2 JAK2 LYN MAPK1 MAPK3 PRL PRLR PTPN1 PTPN6 SH2B1 SOCS1 SOCS2 SOCS3 STAT1 STAT3 STAT5A STAT5B +HATs acetylate histones Reactome Pathway ACTB ACTL6A ATF2 ATXN7 ATXN7L3 BRD1 BRD8 BRPF1 BRPF3 CCDC101 CLOCK CREBBP CSRP2BP DMAP1 DR1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 HAT1 HCFC1 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AG HIST1H2AH HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST3H2A HIST3H2BB IKBKAP ING3 ING4 ING5 JADE1 JADE2 JADE3 KANSL1 KANSL2 KANSL3 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 MBIP MCRS1 MEAF6 MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 OGT PHF20 RBBP7 RUVBL1 RUVBL2 SAP130 SUPT20H SUPT3H SUPT7L TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22 VPS72 WDR5 YEATS2 YEATS4 ZZZ3 +HCN channels Reactome Pathway HCN1 HCN2 HCN3 HCN4 +HDACs deacetylate histones Reactome Pathway ARID4A ARID4B BRMS1 CHD3 CHD4 GATAD2A GATAD2B GPS2 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AG HIST1H2AH HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST3H2A HIST3H2BB HMG20B KDM1A MBD3 MTA1 MTA2 MTA3 NCOR1 NCOR2 PHF21A RBBP4 RBBP7 RCOR1 REST SAP18 SAP30 SAP30L SUDS3 TBL1X TBL1XR1 +HDL-mediated lipid transport Reactome Pathway A2M ABCA1 ABCG1 ALB AMN APOA1 APOC2 APOC3 APOE BMP1 CETP CUBN LCAT PLTP SCARB1 +HDMs demethylate histones Reactome Pathway ARID5B HIST1H3A HIST1H4A HIST2H3A KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A PHF2 PHF8 +HIV Infection Reactome Pathway AAAS AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOBEC3G ARF1 ATP6V1H B2M BANF1 BTRC CCNH CCNT1 CCNT2 CCR5 CD247 CD28 CD4 CD8B CDK7 CDK9 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CTDP1 CUL5 CXCR4 DOCK2 ELL ELMO1 ERCC2 ERCC3 FEN1 FURIN FYN GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 HCK HLA-A HMGA1 KPNA1 KPNB1 LCK LIG1 LIG4 MNAT1 NCBP1 NCBP2 NEDD4L NELFA NELFB NELFCD NELFE NMT1 NMT2 NPM1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PACS1 PAK2 PDCD6IP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PPIA PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RBX1 RCC1 RNGTT RNMT RPS27A SEH1L SKP1 SLC25A4 SLC25A5 SLC25A6 SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 TPR TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 XPO1 XRCC4 XRCC5 XRCC6 env gag gag-pol nef rev tat vif vpr vpu +HIV Life Cycle Reactome Pathway AAAS BANF1 CCNH CCNT1 CCNT2 CCR5 CD4 CDK7 CDK9 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CTDP1 CXCR4 ELL ERCC2 ERCC3 FEN1 FURIN GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 HMGA1 KPNA1 LIG1 LIG4 MNAT1 NCBP1 NCBP2 NEDD4L NELFA NELFB NELFCD NELFE NMT1 NMT2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PDCD6IP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PPIA PSIP1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 RNGTT RNMT RPS27A SEH1L SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 TPR TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 XPO1 XRCC4 XRCC5 XRCC6 env gag gag-pol nef rev tat vif vpr vpu +HIV Transcription Elongation Reactome Pathway CCNH CCNT1 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 tat +HIV Transcription Initiation Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +HIV elongation arrest and recovery Reactome Pathway CCNT1 CCNT2 CDK9 CTDP1 ELL GTF2F1 GTF2F2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +HS-GAG biosynthesis Reactome Pathway AGRN EXT1 EXT2 GLCE GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 NDST1 NDST2 NDST3 NDST4 SDC1 SDC2 SDC3 SDC4 SLC35D2 +HS-GAG degradation Reactome Pathway AGRN GLB1 GLB1L GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB HPSE HPSE2 HSPG2 IDS IDUA NAGLU SDC1 SDC2 SDC3 SDC4 SGSH +HSF1 activation Reactome Pathway COL4A6 CRYBA4 DEDD2 DNAJB1 DNAJB6 EEF1A1 FKBP4 GML HDAC6 HSBP1 HSBP2 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA6 HSPH1 MRPL18 PTGES3 RLN1 RPA1 RPA2 RPA3 SERPINH1 TNFRSF21 UBB VCP YWHAE +HSF1-dependent transactivation Reactome Pathway AKT1S1 CAMK2A CAMK2B CAMK2D CAMK2G COL4A6 CREBBP CRYBA4 DEDD2 DNAJB1 DNAJB6 EP300 FKBP4 GML HSBP1 HSBP2 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPH1 MLST8 MRPL18 MTOR PTGES3 RLN1 RPTOR SERPINH1 TNFRSF21 UBB +Hedgehog 'off' state Reactome Pathway ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 BTRC CSNK1A1 CUL1 DYNC2H1 FUZ GLI1 GLI2 GLI3 GNAS GPR161 GSK3B IFT122 IFT140 IFT172 IFT52 IFT57 IFT88 INTU ITCH KIF3A KIF7 MKS1 NUMB OFD1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTCH1 RBX1 RPGRIP1L RPS27A SKP1 SMO SUFU TTC21B TULP3 UBA52 UBB UBC WDR19 WDR35 +Hedgehog 'on' state Reactome Pathway ADRBK1 ARRB1 ARRB2 BOC CDC73 CDON CSNK1A1 CUL3 DHH DZIP1 EFCAB7 EVC EVC2 GAS1 GAS8 GLI1 GLI2 GLI3 GPR161 HHIP IHH IQCE ITCH KIF3A KIF7 NUMB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTCH1 PTCH2 RBX1 RPS27A SHH SMO SMURF1 SMURF2 SPOP SPOPL SUFU UBA52 UBB UBC ULK3 +Hedgehog ligand biogenesis Reactome Pathway ADAM17 DERL2 DHH DISP2 ERLEC1 GPC5 HHAT IHH NOTUM OS9 P4HB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SCUBE2 SEL1L SHH SYVN1 UBA52 UBB UBC VCP +Heme biosynthesis Reactome Pathway ALAD ALAS1 ALAS2 COX10 COX15 CPOX FECH HMBS PPOX UROD UROS +Heme degradation Reactome Pathway BLVRA BLVRB HMOX1 HMOX2 UGT1A1 UGT1A4 +Hemostasis Reactome Pathway A2M ABCC4 ABL1 ACTN1 ACTN2 ACTN4 ADRA2A ADRA2B ADRA2C AK3 AKAP1 AKAP10 AKT1 AKT2 AKT3 ALB ALDOA AMICA1 ANGPT1 ANGPT2 ANGPT4 ANXA2 APBB1IP APOA1 APOB APP ARRB1 ARRB2 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 BCAR1 BRPF3 BSG C1QBP CABLES1 CABLES2 CALM1 CALU CAP1 CAPZA1 CAPZA2 CAPZB CAV1 CBX5 CD177 CD2 CD244 CD36 CD44 CD47 CD48 CD58 CD63 CD84 CD9 CDC42 CDK2 CDK5 CEACAM1 CEACAM6 CEACAM8 CENPE CFD CFL1 CLU CREBBP CRK CSF2 CSF2RA CSF2RB CSK CXADR DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DOK2 EGF EHD1 EHD2 EHD3 EP300 ESAM F10 F11 F11R F12 F13A1 F13B F2 F2R F2RL2 F2RL3 F3 F5 F7 F8 F9 FCER1G FGA FGB FGG FGR FIGF FLNA FN1 FYN GAB2 GAS6 GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 GLG1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNAS GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GP1BA GP1BB GP5 GP6 GP9 GRB14 GRB2 GRB7 GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3 H3F3A HABP4 HBB HBD HBE1 HBG1 HBG2 HDAC1 HDAC2 HGF HIST1H3A HIST2H3A HMG20B HRAS HRG HSPA5 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IGF1 IGF2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPP5D IRF1 IRF2 IRF3 IRF7 ITGA1 ITGA10 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITPK1 ITPR1 ITPR2 ITPR3 JAK1 JAK2 JAK3 JAM2 JAM3 JMJD1C KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KDM1A KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 KLKB1 KNG1 KRAS L1CAM LAMP2 LAT LCK LCP2 LEFTY2 LRP8 LRRC16A LYN MAFF MAFG MAFK MAG MAPK1 MAPK14 MAPK3 MERTK MFN1 MFN2 MGLL MMP1 MMRN1 MPL MRVI1 MYB NFE2 NOS1 NOS2 NOS3 NRAS OLR1 ORAI1 P2RX1 P2RY1 P2RY12 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE9A PDGFA PDGFB PDPK1 PECAM1 PF4 PF4V1 PFN1 PHF21A PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLAT PLAU PLAUR PLCG1 PLCG2 PLEK PLG POTEKP PPBP PPIA PPIL2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRCP PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ PRKG1 PRKG2 PROC PROCR PROS1 PRTN3 PSAP PTGIR PTK2 PTPN1 PTPN11 PTPN6 RAB5A RAC1 RAC2 RACGAP1 RAD51B RAD51C RAF1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RCOR1 RHOA RHOB RHOG S100A10 SCG3 SELE SELL SELP SELPLG SERPINA1 SERPINA5 SERPINB2 SERPINB6 SERPINB8 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINF2 SERPING1 SH2B1 SH2B2 SH2B3 SHC1 SIN3A SIRPA SIRPG SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SOD1 SOS1 SPARC SPN SRC SRGN STIM1 STX4 STXBP3 SYK TBXA2R TEK TF TFPI TGFB1 TGFB2 TGFB3 THBD THBS1 THPO TIMP1 TLN1 TMSB4X TP53 TREM1 TRPC3 TRPC6 TRPC7 TTN TUBA4A VAV1 VAV2 VAV3 VCL VEGFA VEGFB VEGFC VPS45 VWF WDR1 WEE1 YES1 YWHAZ ZFPM1 ZFPM2 ZFYVE20 +Heparan sulfate/heparin (HS-GAG) metabolism Reactome Pathway AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 CSPG5 DCN EXT1 EXT2 GLB1 GLB1L GLCE GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 IDS IDUA NAGLU NCAN NDST1 NDST2 NDST3 NDST4 SDC1 SDC2 SDC3 SDC4 SGSH SLC35D2 VCAN +Hexose transport Reactome Pathway AAAS G6PC G6PC2 G6PC3 GCK GCKR HK1 HK2 HK3 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC37A4 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A9 TPR +Hh ligand biogenesis disease Reactome Pathway DERL2 DHH ERLEC1 HHAT IHH OS9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SEL1L SHH SYVN1 UBA52 UBB UBC VCP +Highly calcium permeable nicotinic acetylcholine receptors Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 +Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 +Highly sodium permeable acetylcholine nicotinic receptors Reactome Pathway CHRNA3 CHRNA4 CHRNB2 CHRNB4 CHRND CHRNE CHRNG +Histamine receptors Reactome Pathway HRH1 HRH2 HRH3 HRH4 +Histidine catabolism Reactome Pathway AMDHD1 FTCD HAL HDC UROC1 +Homologous DNA pairing and strand exchange Reactome Pathway BRCA2 BRIP1 RAD51 RAD52 RPA1 RPA2 RPA3 +Homologous Recombination Repair Reactome Pathway APEX1 ATM BRCA1 BRCA2 BRIP1 H2AFX LIG1 MDC1 MRE11A NBN RAD50 RAD51 RAD52 RPA1 RPA2 RPA3 TP53BP1 +Homologous recombination repair of replication-independent double-strand breaks Reactome Pathway APEX1 ATM BRCA1 BRCA2 BRIP1 H2AFX LIG1 MDC1 MRE11A NBN RAD50 RAD51 RAD52 RPA1 RPA2 RPA3 TP53BP1 +Hormone ligand-binding receptors Reactome Pathway CGA FSHB FSHR GNRH1 GNRH2 GNRHR GNRHR2 LHB LHCGR TSHB TSHR +Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Reactome Pathway ABHD5 CAV1 FABP4 LIPE MGLL PLIN1 PPP1CA PPP1CB PPP1CC PRKACA PRKACB PRKACG +Host Interactions of HIV factors Reactome Pathway AAAS AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOBEC3G ARF1 ATP6V1H B2M BANF1 BTRC CCNT1 CD247 CD28 CD4 CD8B CDK9 CUL5 DOCK2 ELMO1 FYN HCK HLA-A HMGA1 KPNA1 KPNB1 LCK NPM1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PACS1 PAK2 POM121 PPIA PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RBX1 RCC1 RPS27A SEH1L SKP1 SLC25A4 SLC25A5 SLC25A6 TCEB1 TCEB2 TPR UBA52 UBB UBC XPO1 gag gag-pol nef rev tat vif vpr vpu +Host Interactions with Influenza Factors Reactome Pathway CPSF4 EIF2AK2 NA NS PABPN1 PB1 SLC25A6 TGFB1 +HuR stabilizes mRNA Reactome Pathway ANP32A ELAVL1 NUP214 PRKCA PRKCD SET TNFSF13 XPO1 +Hyaluronan biosynthesis and export Reactome Pathway ABCC5 HAS1 HAS2 HAS3 +Hyaluronan metabolism Reactome Pathway ABCC5 CD44 CHP1 GUSB HAS1 HAS2 HAS3 HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 LYVE1 SLC9A1 STAB2 +Hyaluronan uptake and degradation Reactome Pathway CD44 CHP1 GUSB HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 LYVE1 SLC9A1 STAB2 +Hydrolysis of LPC Reactome Pathway GPCPD1 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLBD1 +Hydrolysis of LPE Reactome Pathway GPCPD1 PLA2G4C +Hydroxycarboxylic acid-binding receptors Reactome Pathway HCAR1 HCAR2 HCAR3 +Hypusine synthesis from eIF5A-lysine Reactome Pathway DHPS DOHH EIF5A EIF5A2 +IGF1R signaling cascade Reactome Pathway AKT2 CAB39 CAB39L CDK1 DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 HRAS IGF1 IGF1R IGF2 IL6 IL6R IL6ST IRS1 IRS2 IRS4 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +IKK complex recruitment mediated by RIP1 Reactome Pathway BIRC2 BIRC3 CD14 CHUK IKBKB IKBKG LY96 RIPK1 RIPK3 RPS27A SARM1 TICAM1 TICAM2 TLR3 TLR4 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 +IRAK1 recruits IKK complex Reactome Pathway CHUK IKBKB IKBKG IRAK1 PELI1 PELI2 PELI3 TRAF6 UBE2N UBE2V1 +IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Reactome Pathway CHUK IKBKB IKBKG IRAK1 PELI1 PELI2 PELI3 TRAF6 UBE2N UBE2V1 +IRAK2 mediated activation of TAK1 complex Reactome Pathway IRAK2 MAP3K7 RPS27A TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC +IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Reactome Pathway IRAK2 MAP3K7 RPS27A TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC +IRE1alpha activates chaperones Reactome Pathway ACADVL ADD1 ARFGAP1 ATP6V0D1 ATPV0D1 C19orf10 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DNAJB11 DNAJB9 DNAJC3 EDEM1 ERN1 EXTL3 FKBP14 FKBP14 gene GFPT1 GOSR2 GSK3A HDGF HSPA5 HYOU1 KDELR3 KLHDC3 LMNA PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPR SRPRB SSR1 SULT1A3 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +IRF3 mediated activation of type 1 IFN Reactome Pathway DTX4 IRF3 NLRP4 TBK1 TMEM173 ZBP1 +IRF3-mediated induction of type I IFN Reactome Pathway DDX41 DTX4 IFI16 IRF3 MRE11A NLRP4 PRKDC TBK1 TMEM173 TREX1 XRCC5 XRCC6 ZBP1 +IRS activation Reactome Pathway DOK1 GRB10 INS INSR IRS1 IRS2 +IRS-mediated signalling Reactome Pathway AKT2 CAB39 CAB39L CDK1 DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 HRAS IL6 IL6R IL6ST IRS1 IRS2 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +IRS-related events Reactome Pathway AKT2 CAB39 CAB39L CDK1 DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB10 GRB2 HRAS IL6 IL6R IL6ST INS INSR IRS1 IRS2 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +IRS-related events triggered by IGF1R Reactome Pathway AKT2 CAB39 CAB39L CDK1 DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 HRAS IGF1 IGF1R IGF2 IL6 IL6R IL6ST IRS1 IRS2 IRS4 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +ISG15 antiviral mechanism Reactome Pathway AAAS ARIH1 DDX58 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FLNB HERC5 IFIT1 IRF3 ISG15 JAK1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 MAPK3 MX1 MX2 NEDD4 NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PIN1 PLCG1 POM121 PPM1B RAE1 RANBP2 RPS27A SEH1L STAT1 TPR TRIM25 UBA52 UBA7 UBB UBC UBE2E1 UBE2L6 UBE2N USP18 USP41 gag +Immune System Reactome Pathway AAAS ABI1 ABI2 ABL1 ACTB ACTG1 ACTR1A ACTR1B ACTR2 ACTR3 ADAM17 ADAR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGER AGO1 AGO2 AGO3 AGO4 AIM2 AKT1 AKT1S1 AKT2 AKT3 AMICA1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APP ARF1 ARIH1 ARIH2 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ART1 ASB1 ASB10 ASB11 ASB12 ASB13 ASB14 ASB15 ASB16 ASB17 ASB18 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATF1 ATF2 ATG12 ATG5 ATG7 B2M BAD BAIAP2 BCL10 BCL2 BCL2L1 BIRC2 BIRC3 BLK BLMH BLNK BRK1 BST2 BTC BTK BTLA BTRC C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CALM1 CALR CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CANX CAPZA1 CAPZA2 CARD11 CARD9 CASP1 CASP10 CASP2 CASP4 CASP8 CASP9 CBL CBLB CCR2 CCR6 CD14 CD160 CD180 CD19 CD200 CD200R1 CD207 CD226 CD247 CD274 CD28 CD300E CD300LB CD34 CD36 CD3D CD3E CD3G CD4 CD40 CD40LG CD44 CD46 CD55 CD59 CD74 CD79A CD79B CD80 CD81 CD86 CD8A CD8B CD96 CDC16 CDC20 CDC23 CDC26 CDC27 CDC34 CDC42 CDH1 CDK1 CDKN1A CDKN1B CENPE CFB CFD CFH CFHR3 CFI CFL1 CHUK CIITA CISH CLEC5A CLTA CLTC CNPY3 CR1 CRCP CREB1 CREBBP CRK CRKL CRP CRTAM CSF2 CSF2RA CSF2RB CSH1 CSK CTLA4 CTNNB1 CTSA CTSB CTSC CTSD CTSE CTSF CTSH CTSK CTSL CTSO CTSS CTSV CUL1 CUL2 CUL3 CUL5 CUL7 CXADR CYBA CYBB CYFIP2 CYLD DAK DAPP1 DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DDOST DDX41 DDX58 DEFA1 DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB104A DEFB105A DEFB106A DEFB107A DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB4A DET1 DHX36 DHX58 DHX9 DNM1 DNM2 DNM3 DOCK1 DTX3L DTX4 DUSP3 DUSP4 DUSP6 DUSP7 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DZIP3 ECSIT EEA1 EGF EGFR EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 ELK1 ELMO1 ELMO2 ENAH EP300 ERAP1 ERAP2 ERBB2 ERBB3 ERBB4 EREG EVL FADD FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCER1A FCER1G FCGR1A FCGR1B FCGR2A FCGR2B FCGR3A FCN1 FCN2 FCN3 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FGR FLNB FOS FOXO1 FOXO3 FOXO4 FRS2 FYB FYN FZR1 GAB1 GAB2 GAN GBP1 GBP2 GBP3 GBP4 GBP5 GBP6 GBP7 GH1 GH2 GHR GLYCAM1 GRAP2 GRB2 GSK3A GSK3B GZMM HBEGF HCK HCST HECTD3 HERC2 HERC5 HGF HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G HMGB1 HRAS HSP90AA1 HSP90AB1 HSP90B1 HSPA5 HUWE1 ICAM1 ICAM2 ICAM3 ICAM4 ICOS ICOSLG IFI16 IFI27 IFI30 IFI35 IFI6 IFIH1 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IGHD IGHE IGHG1 IGHG2 IGHG3 IGHG4 IGHM IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IKBKB IKBKE IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPP5D INPPL1 IP6K2 IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 IRS1 IRS2 ISG15 ISG20 ITCH ITGA4 ITGAL ITGAM ITGAV ITGB1 ITGB2 ITGB5 ITGB7 ITK ITPR1 ITPR2 ITPR3 JAK1 JAK2 JAK3 JUN KEAP1 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIFAP3 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DL2 KIR3DS1 KIT KITLG KL KLB KLC1 KLC2 KLC3 KLC4 KLHL13 KLHL20 KLHL21 KLHL9 KLRC1 KLRC2 KLRD1 KLRG1 KLRK1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 KRAS LAT LAT2 LBP LCK LCP2 LGALS3 LGMN LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LIMK1 LNPEP LRR1 LRRC41 LRRFIP1 LRSAM1 LY86 LY96 LYN MADCAM1 MALT1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K14 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAP1 MAPKAPK2 MAPKAPK3 MASP1 MASP2 MAVS MB21D1 MBL2 MDM2 MEF2A MEF2C MEFV MGRN1 MICA MICB MID1 MIR26A1 MIR26A2 MKRN1 MLST8 MOV10 MRC1 MRC2 MRE11A MS4A2 MT2A MTOR MX1 MX2 MYD88 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCAM1 NCF1 NCF2 NCF4 NCK1 NCKAP1 NCKIPSD NCR2 NEDD4 NEDD4L NFATC1 NFATC2 NFATC3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NLRC4 NLRC5 NLRP1 NLRP3 NLRP4 NLRX1 NOD1 NOD2 NPEPPS NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL ORAI1 OSBPL1A OTUD5 P2RX7 PAG1 PAK1 PAK2 PAK3 PANX1 PARK2 PCBP2 PDCD1 PDCD1LG2 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDIA3 PDPK1 PELI1 PELI2 PELI3 PHLPP1 PHLPP2 PIAS1 PIK3AP1 PIK3C3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIN1 PJA1 PJA2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PML POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POM121 PPAPDC1A PPAPDC1B PPM1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCSH PRKDC PRKG1 PRL PRLR PROS1 PRSS2 PRSS3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PSTPIP1 PTAFR PTEN PTK2 PTK2B PTPN1 PTPN11 PTPN2 PTPN6 PTPRC PVR PVRL2 PYCARD RAB7A RAC1 RACGAP1 RAE1 RAET1E RAF1 RANBP2 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF1 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RBCK1 RBX1 RCHY1 REL RELA RICTOR RILP RIPK1 RIPK2 RIPK3 RNASEL RNF111 RNF123 RNF125 RNF135 RNF138 RNF144B RNF182 RNF19B RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 RSAD2 S100A12 S100B SAA1 SAMHD1 SAR1B SARM1 SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SEH1L SELL SH2B1 SH3GL2 SH3KBP1 SHC1 SIGIRR SIGLEC14 SIGLEC15 SIGLEC16 SIKE1 SIPA1 SIRPB1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS2 SOCS3 SOS1 SP100 SPSB1 SPSB2 SPSB4 SPTBN2 SQSTM1 SRC SRMS STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 STIM1 STUB1 SUGT1 SUMO1 SYK TAB1 TAB2 TAB3 TANK TAP1 TAP2 TAPBP TAX1BP1 TBK1 TCEB1 TCEB2 TCRA TCRB TEC THEM4 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMEM173 TNFAIP3 TNFRSF14 TNIP2 TNRC6A TNRC6B TNRC6C TOLLIP TPP2 TPR TRAC TRAF2 TRAF3 TRAF6 TRAT1 TRBC1 TRBV12-3 TREM1 TREM2 TREX1 TRIB3 TRIM10 TRIM11 TRIM14 TRIM17 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM32 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM56 TRIM6 TRIM62 TRIM63 TRIM68 TRIM8 TRIM9 TRIP12 TRPC1 TSC2 TXK TXN TXNIP TYK2 TYROBP UBA1 UBA3 UBA5 UBA52 UBA6 UBA7 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 ULBP1 ULBP3 UNC93B1 USP18 USP41 VASP VAV1 VAV2 VAV3 VCAM1 VHL VPRBP VTN WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 WSB1 WWP1 XAF1 XRCC5 XRCC6 YES1 YWHAB YWHAZ ZAP70 ZBP1 ZBTB16 ZFYVE20 cd21 env fliC fljB gag hly porB prgJ +Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Reactome Pathway AMICA1 B2M C3 CD160 CD19 CD200 CD200R1 CD226 CD247 CD34 CD3D CD3E CD3G CD40 CD40LG CD81 CD8A CD8B CD96 CDH1 CRTAM CXADR FCGR2B FCGR3A GLYCAM1 HCST HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G ICAM1 ICAM2 ICAM3 ICAM4 IFITM1 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 ITGA4 ITGAL ITGB1 ITGB2 ITGB7 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR3DL1 KIR3DL2 KLRC1 KLRD1 KLRG1 KLRK1 LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 MADCAM1 MICA MICB PVR PVRL2 RAET1E SELL TCRA TCRB TRAC TRBC1 TRBV12-3 TYROBP ULBP1 ULBP3 VCAM1 cd21 +Import of palmitoyl-CoA into the mitochondrial matrix Reactome Pathway ACACA ACACB CPT1A CPT1B CPT2 PPARD PRKAA2 PRKAB2 PRKAG2 RXRA SLC25A20 +Inactivation of APC/C via direct inhibition of the APC/C complex Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 UBE2C UBE2D1 UBE2E1 +Inactivation of Cdc42 and Rac Reactome Pathway ARHGAP39 CDC42 GPC1 RAC1 ROBO1 SLIT2 SRGAP1 SRGAP2 SRGAP3 +Inactivation, recovery and regulation of the phototransduction cascade Reactome Pathway CALM1 CNGA1 CNGB1 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GRK1 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT1 NMT2 PDE6A PDE6B PDE6G PPEF1 PRKCA PRKCQ RCVRN RGS9 RGS9BP RHO SAG +Incretin synthesis, secretion, and inactivation Reactome Pathway CDX2 CTNNB1 DPP4 FFAR1 FFAR4 GATA4 GCG GIP GNAT3 GNB3 GNG13 GPR119 GRP ISL1 LEP PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 TCF7L2 +Inflammasomes Reactome Pathway AIM2 APP BCL2 BCL2L1 CASP1 HSP90AB1 MEFV NLRC4 NLRP1 NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD SUGT1 TXN TXNIP fliC fljB hly prgJ +Influenza Infection Reactome Pathway AAAS CALR CANX CLTA CPSF4 DNAJC3 EIF2AK2 FAU GRSF1 GTF2F1 GTF2F2 HA HSP90AA1 HSPA1A IPO5 KPNA1 KPNB1 M NA NP NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PABPN1 PB1 PB2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP2 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SEH1L SLC25A6 TGFB1 TPR UBA52 XPO1 +Influenza Life Cycle Reactome Pathway AAAS CALR CANX CLTA DNAJC3 FAU GRSF1 GTF2F1 GTF2F2 HA HSP90AA1 HSPA1A IPO5 KPNA1 KPNB1 M NA NP NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP2 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SEH1L TPR UBA52 XPO1 +Influenza Viral RNA Transcription and Replication Reactome Pathway AAAS DNAJC3 FAU GRSF1 GTF2F1 GTF2F2 HA HSP90AA1 IPO5 M NA NP NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RANBP2 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SEH1L TPR UBA52 +Influenza Virus Induced Apoptosis Reactome Pathway NA PB1 SLC25A6 TGFB1 +Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Reactome Pathway GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +Inhibition of HSL Reactome Pathway AKT2 PDE3B +Inhibition of Host mRNA Processing and RNA Silencing Reactome Pathway CPSF4 NS PABPN1 +Inhibition of IFN-beta Reactome Pathway NS +Inhibition of Interferon Synthesis Reactome Pathway NS +Inhibition of PKR Reactome Pathway EIF2AK2 NS +Inhibition of Signaling by Overexpressed EGFR Reactome Pathway EGF EGFR +Inhibition of TSC complex formation by PKB Reactome Pathway AKT2 TSC1 TSC2 +Inhibition of adenylate cyclase pathway Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAI1 GNAI2 GNAI3 GNAL GNAT3 +Inhibition of replication initiation of damaged DNA by RB1/E2F1 Reactome Pathway E2F1 POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 TFDP1 +Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 UBE2C UBE2D1 UBE2E1 +Initial triggering of complement Reactome Pathway C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B CFB CFD CRP FCN1 FCN2 FCN3 GZMM IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 MASP1 MASP2 MBL2 +Initiation of Nuclear Envelope Reformation Reactome Pathway ANKLE2 BANF1 EMD LEMD2 LEMD3 LMNA LMNB1 PPP2CA PPP2R1A PPP2R2A TMPO VRK1 VRK2 +Innate Immune System Reactome Pathway ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGER AGO1 AGO2 AGO3 AGO4 AIM2 AKT1 AKT1S1 AKT2 AKT3 APP ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ART1 ATF1 ATF2 ATG12 ATG5 B2M BAD BAIAP2 BCL10 BCL2 BCL2L1 BIRC2 BIRC3 BRK1 BTC BTK C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CALM1 CAMK4 CAPZA1 CAPZA2 CARD11 CARD9 CASP1 CASP10 CASP2 CASP4 CASP8 CASP9 CCR2 CCR6 CD14 CD180 CD19 CD247 CD28 CD300E CD300LB CD36 CD3G CD4 CD46 CD55 CD59 CD80 CD86 CDC42 CDK1 CDKN1A CDKN1B CFB CFD CFH CFHR3 CFI CFL1 CHUK CLEC5A CNPY3 CR1 CRCP CREB1 CREBBP CRK CRP CTNNB1 CTSB CTSK CTSL CTSS CTSV CYFIP2 CYLD DAK DDOST DDX41 DDX58 DEFA1 DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB104A DEFB105A DEFB106A DEFB107A DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB4A DHX36 DHX58 DHX9 DNM1 DNM2 DNM3 DOCK1 DTX4 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT EEA1 EGF EGFR ELK1 ELMO1 ELMO2 EP300 ERBB2 ERBB3 ERBB4 EREG FADD FCER1A FCER1G FCGR1A FCGR2A FCGR3A FCN1 FCN2 FCN3 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FGR FOS FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GAB2 GRAP2 GRB2 GSK3A GSK3B GZMM HBEGF HCK HERC5 HLA-B HLA-C HLA-E HMGB1 HRAS HSP90AA1 HSP90AB1 HSP90B1 IFI16 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IGHE IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF7 IRS1 IRS2 ISG15 ITCH ITGAM ITGB2 ITK ITPR1 ITPR2 ITPR3 JAK1 JAK2 JUN KIR2DS2 KIR2DS4 KIR2DS5 KIR3DS1 KIT KITLG KL KLB KLRC2 KLRD1 KLRK1 KRAS LAT LAT2 LBP LCK LCP2 LGALS3 LGMN LIMK1 LRRFIP1 LY86 LY96 LYN MALT1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAP1 MAPKAPK2 MAPKAPK3 MASP1 MASP2 MAVS MB21D1 MBL2 MDM2 MEF2A MEF2C MEFV MIR26A1 MIR26A2 MLST8 MOV10 MRE11A MS4A2 MTOR MYD88 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKIPSD NCR2 NFATC1 NFATC2 NFATC3 NFKB1 NFKB2 NFKBIA NFKBIB NLRC4 NLRC5 NLRP1 NLRP3 NLRP4 NLRX1 NOD1 NOD2 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 OTUD5 P2RX7 PAK1 PAK2 PAK3 PANX1 PCBP2 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PELI1 PELI2 PELI3 PHLPP1 PHLPP2 PIK3C3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIN1 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K PPAPDC1A PPAPDC1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PRKCQ PRKCSH PRKDC PROS1 PRSS2 PRSS3 PSTPIP1 PTEN PTK2 PTPN11 PYCARD RAC1 RAF1 RASGRP1 RASGRP2 RASGRP4 RELA RICTOR RIPK1 RIPK2 RIPK3 RNF125 RNF135 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 S100A12 S100B SAA1 SARM1 SHC1 SIGIRR SIGLEC14 SIGLEC15 SIGLEC16 SIKE1 SIRPB1 SOCS1 SOS1 SRC STAT6 SUGT1 SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TBK1 TEC THEM4 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMEM173 TNFAIP3 TNRC6A TNRC6B TNRC6C TRAF2 TRAF3 TRAF6 TRAT1 TREM1 TREM2 TREX1 TRIB3 TRIM21 TRIM25 TRIM32 TRIM56 TSC2 TXK TXN TXNIP TYK2 TYROBP UBA52 UBA7 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 UBE2N UBE2V1 UNC93B1 VAV1 VAV2 VAV3 VTN WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 XRCC5 XRCC6 YES1 YWHAB ZBP1 ZFYVE20 env fliC fljB hly porB prgJ +Inositol phosphate metabolism Reactome Pathway CALM1 IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5D INPP5J INPPL1 IP6K1 IP6K2 IP6K3 IPMK IPPK ISYNA1 ITPK1 ITPKA ITPKB ITPKC MINPP1 NUDT10 NUDT11 NUDT3 NUDT4 OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PPIP5K1 PPIP5K2 PTEN SYNJ1 +Inositol transporters Reactome Pathway SLC2A13 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A4 SLC5A9 +Insulin effects increased synthesis of Xylulose-5-Phosphate Reactome Pathway TALDO1 TKT +Insulin processing Reactome Pathway CPE CPN1 ERO1L ERO1LB EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 INS KIF5A KIF5B KIF5C MYO5A PCSK1 PCSK2 RAB27A SLC30A5 SLC30A6 SLC30A7 SLC30A8 STX1A VAMP2 +Insulin receptor recycling Reactome Pathway ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H INS INSR TCIRG1 +Insulin receptor signalling cascade Reactome Pathway AKT2 CAB39 CAB39L CDK1 CRK DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB10 GRB2 HRAS IL6 IL6R IL6ST INS INSR IRS1 IRS2 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA Reactome Pathway ACTB CD44 H19 IGF2 IGF2BP1 IGF2BP2 IGF2BP3 MYC +Integration of energy metabolism Reactome Pathway ABCC8 ACACA ACACB ACLY ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A ADRA2C AGPAT1 AKAP5 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CHRM3 FASN FFAR1 GCG GCGR GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 INS IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 MARCKS MLX MLXIPL PFKFB1 PKLR PLCB1 PLCB2 PLCB3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAPGEF3 RAPGEF4 SLC25A4 SLC25A5 SLC25A6 SLC2A1 SLC2A2 SNAP25 STK11 STX1A STXBP1 SYT5 TALDO1 TKT VAMP2 +Integration of provirus Reactome Pathway BANF1 HMGA1 KPNA1 LIG4 PPIA PSIP1 XRCC4 XRCC5 XRCC6 gag gag-pol rev vif vpr vpu +Integration of viral DNA into host genomic DNA Reactome Pathway BANF1 HMGA1 PSIP1 gag gag-pol rev vif vpr vpu +Integrin alphaIIb beta3 signaling Reactome Pathway AKT1 APBB1IP BCAR1 CRK CSK FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK TLN1 VWF +Integrin cell surface interactions Reactome Pathway AGRN BSG CD44 CD47 CDH1 COL13A1 COL16A1 COL18A1 COL23A1 COL4A1 COL4A2 COL4A3 COL4A4 COL9A1 COL9A2 COL9A3 COMP DAG1 F11R FBN1 FGA FGB FGG FN1 HSPG2 IBSP ICAM1 ICAM2 ICAM3 ICAM4 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB5 ITGB6 ITGB7 ITGB8 JAM2 JAM3 KDR LUM MADCAM1 PECAM1 SPP1 THBS1 TNC VCAM1 VTN +Interaction With Cumulus Cells Reactome Pathway SPAM1 +Interaction With The Zona Pellucida Reactome Pathway ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 OVGP1 ZP1 ZP2 ZP3 ZP4 +Interaction between L1 and Ankyrins Reactome Pathway ANK1 ANK2 ANK3 KCNQ2 KCNQ3 L1CAM NFASC NRCAM SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 +Interactions of Rev with host cellular proteins Reactome Pathway AAAS KPNB1 NPM1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 SEH1L TPR XPO1 rev +Interactions of Tat with host cellular proteins Reactome Pathway CCNT1 CDK9 tat +Interactions of Vpr with host cellular proteins Reactome Pathway AAAS BANF1 HMGA1 KPNA1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 PSIP1 RAE1 RANBP2 SEH1L SLC25A4 SLC25A5 SLC25A6 TPR gag gag-pol rev vif vpr vpu +Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Reactome Pathway ADHFE1 D2HGDH L2HGDH +Interconversion of polyamines Reactome Pathway PAOX SAT1 SMOX +Interferon Signaling Reactome Pathway AAAS ADAR ARIH1 B2M BST2 CAMK2A CAMK2B CAMK2D CAMK2G CD44 CIITA DDX58 EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FCGR1A FCGR1B FLNB GBP1 GBP2 GBP3 GBP4 GBP5 GBP6 GBP7 HERC5 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G ICAM1 IFI27 IFI30 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 JAK1 JAK2 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 MAPK3 MID1 MT2A MX1 MX2 NCAM1 NEDD4 NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL PIAS1 PIN1 PLCG1 PML POM121 PPM1B PRKCD PSMB8 PTAFR PTPN1 PTPN11 PTPN2 PTPN6 RAE1 RANBP2 RNASEL RPS27A RSAD2 SAMHD1 SEH1L SOCS1 SOCS3 SP100 STAT1 STAT2 SUMO1 TPR TRIM10 TRIM14 TRIM17 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM34 TRIM35 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM6 TRIM62 TRIM68 TRIM8 TYK2 UBA52 UBA7 UBB UBC UBE2E1 UBE2L6 UBE2N USP18 USP41 VCAM1 XAF1 gag +Interferon alpha/beta signaling Reactome Pathway ADAR BST2 EGR1 GBP2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G IFI27 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 JAK1 MX1 MX2 OAS1 OAS2 OAS3 OASL PSMB8 PTPN1 PTPN11 PTPN6 RNASEL RSAD2 SAMHD1 SOCS1 SOCS3 STAT1 STAT2 TYK2 USP18 XAF1 +Interferon gamma signaling Reactome Pathway B2M CAMK2A CAMK2B CAMK2D CAMK2G CD44 CIITA FCGR1A FCGR1B GBP1 GBP2 GBP3 GBP4 GBP5 GBP6 GBP7 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G ICAM1 IFI30 IFNG IFNGR1 IFNGR2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 JAK1 JAK2 MID1 MT2A NCAM1 OAS1 OAS2 OAS3 OASL PIAS1 PML PRKCD PTAFR PTPN1 PTPN11 PTPN2 PTPN6 SOCS1 SOCS3 SP100 STAT1 SUMO1 TRIM10 TRIM14 TRIM17 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM34 TRIM35 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM6 TRIM62 TRIM68 TRIM8 VCAM1 +Interleukin receptor SHC signaling Reactome Pathway CSF2 CSF2RA CSF2RB GAB2 GRB2 HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN6 SHC1 SOS1 +Interleukin-1 processing Reactome Pathway CASP1 IL18 IL1A IL1B NFKB1 NFKB2 RELA +Interleukin-1 signaling Reactome Pathway BTRC CHUK CUL1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 MAP2K1 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MYD88 NFKB1 NOD1 NOD2 PELI1 PELI2 PELI3 RBX1 RIPK2 SKP1 SQSTM1 TAB1 TAB2 TAB3 TNIP2 TOLLIP TRAF6 UBE2N UBE2V1 +Interleukin-2 signaling Reactome Pathway CDK1 CSF2 CSF2RA CSF2RB GAB2 GRB2 HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST INPP5D INPPL1 JAK1 JAK2 JAK3 KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTK2B PTPN11 PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B SYK TYK2 YWHAB +Interleukin-3, 5 and GM-CSF signaling Reactome Pathway BLNK CBL CRK CRKL CSF2 CSF2RA CSF2RB FYN GAB2 GRB2 HCK HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACA PTPN11 PTPN6 RAPGEF1 SHC1 SOS1 STAT5A STAT5B SYK TEC VAV1 YES1 YWHAZ +Interleukin-6 signaling Reactome Pathway CBL IL6 IL6R IL6ST JAK1 JAK2 PTPN11 SOCS3 STAT1 STAT3 TYK2 +Interleukin-7 signaling Reactome Pathway HGF IL2RG IL7 IL7R JAK1 JAK3 PIK3R1 PIK3R2 PIK3R3 STAT5A STAT5B +Intraflagellar transport Reactome Pathway CLUAP1 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 HSPB11 IFT122 IFT140 IFT172 IFT20 IFT22 IFT27 IFT43 IFT46 IFT52 IFT57 IFT74 IFT80 IFT81 IFT88 KIF17 KIF3A KIF3B KIF3C KIFAP3 TCTE3 TCTEX1D1 TCTEX1D2 TNPO1 TRAF3IP1 TRIP11 TTC21B TTC26 TTC30A TTC30B WDR19 WDR34 WDR35 WDR60 +Intrinsic Pathway Reactome Pathway A2M C1QBP F10 F11 F12 F2 F8 F9 GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PRCP PROC SERPINA5 SERPINC1 SERPIND1 SERPINE2 SERPING1 VWF +Intrinsic Pathway for Apoptosis Reactome Pathway AKT1 AKT2 AKT3 APAF1 BAD BAK1 BAX BBC3 BCL2 BCL2L1 BCL2L11 BID BMF CASP3 CASP7 CASP8 CASP9 CYCS DIABLO DYNLL1 DYNLL2 E2F1 GZMB MAPK8 NMT1 PMAIP1 PPP3CC PPP3R1 SFN TFDP1 TP53 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Inwardly rectifying K+ channels Reactome Pathway ABCC8 ABCC9 GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 +Ion channel transport Reactome Pathway ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ARHGEF9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B BEST1 BEST2 BEST3 BEST4 BSND CLCA1 CLCA2 CLCA3P CLCA4 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB CLIC2 FKBP1B FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GLRA1 GLRA2 GLRA3 GLRA4 GLRB HTR3A HTR3B HTR3C HTR3D HTR3E MCOLN1 MCOLN2 MCOLN3 NALCN NEDD4L OSTM1 PDZD11 PLN RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK2 SGK3 SLC17A3 SLC9B1 SLC9B2 SLC9C1 SLC9C2 SRI TPCN1 TPCN2 TRDN TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 TSC22D3 TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UNC79 UNC80 WNK1 WNK2 WNK3 WNK4 WWP1 +Ion transport by P-type ATPases Reactome Pathway ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 PDZD11 PLN +Ionotropic activity of Kainate Receptors Reactome Pathway CALM1 DLG1 DLG3 DLG4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD +Iron uptake and transport Reactome Pathway ABCG2 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CP CYBRD1 FLVCR1 FTH1 FTL HEPH HMOX1 HMOX2 LCN2 MCOLN1 SLC11A2 SLC22A17 SLC40A1 SLC46A1 STEAP2 STEAP3 TCIRG1 TF TFRC +JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Reactome Pathway IKBKG IRAK1 IRAK2 MAP2K4 MAP2K7 MAP3K7 MAPK10 MAPK8 MAPK9 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TRAF6 +KSRP destabilizes mRNA Reactome Pathway AKT1 DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KHSRP MAPK11 MAPK14 PARN YWHAZ +Keratan sulfate biosynthesis Reactome Pathway ACAN B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CHST1 CHST2 CHST5 CHST6 FMOD KERA LUM OGN OMD PRELP SLC35D2 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 +Keratan sulfate degradation Reactome Pathway ACAN FMOD GLB1 GLB1L GNS HEXA HEXB KERA LUM OGN OMD PRELP +Keratan sulfate/keratin metabolism Reactome Pathway ACAN B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CHST1 CHST2 CHST5 CHST6 FMOD GLB1 GLB1L GNS HEXA HEXB KERA LUM OGN OMD PRELP SLC35D2 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 +Ketone body metabolism Reactome Pathway ACAT1 BDH1 HMGCL HMGCS2 OXCT1 +Kinesins Reactome Pathway CENPE KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 RACGAP1 +Klotho-mediated ligand binding Reactome Pathway FGF19 FGF23 FGFR1 FGFR4 KL KLB +L13a-mediated translational silencing of Ceruloplasmin expression Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H FAU PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +L1CAM interactions Reactome Pathway ALCAM ANK1 ANK2 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CD24 CHL1 CLTA CNTN1 CNTN2 CNTN6 CNTNAP1 CSNK2A1 CSNK2A2 CSNK2B DCX DLG1 DLG3 DLG4 DNM1 DNM2 DNM3 DPYSL2 EGFR EPHB2 EZR FGFR1 HSPA8 ITGA1 ITGA10 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 KCNQ2 KCNQ3 KIAA1598 KIF4A KIF4B L1CAM LAMA1 LAMB1 LAMC1 MAP2K1 MAP2K2 MAPK1 MAPK3 MSN NCAM1 NCAN NFASC NRCAM NRP1 NRP2 NUMB PAK1 RAC1 RANBP9 RDX RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SDCBP SH3GL2 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC VAV2 +LDL-mediated lipid transport Reactome Pathway APOB APOF CETP LDLR LDLRAP1 LPA +LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome Pathway CREBBP CTNNB1 EP300 IRF3 LRRFIP1 +Lagging Strand Synthesis Reactome Pathway APEX1 DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Laminin interactions Reactome Pathway COL18A1 HSPG2 ITGA1 ITGA2 ITGA3 ITGA6 ITGA7 ITGAV ITGB1 ITGB4 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 NID1 NID2 +Late Phase of HIV Life Cycle Reactome Pathway AAAS CCNH CCNT1 CCNT2 CDK7 CDK9 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CTDP1 ELL ERCC2 ERCC3 FURIN GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NEDD4L NELFA NELFB NELFCD NELFE NMT1 NMT2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PDCD6IP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PPIA RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 RNGTT RNMT RPS27A SEH1L SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 TPR TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 XPO1 env gag gag-pol nef rev tat vif vpr vpu +Latent infection of Homo sapiens with Mycobacterium tuberculosis Reactome Pathway ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CAMP CYBA CYBB LTF MT2748 NCF1 NCF2 NCF4 NOS1 NOS2 NOS3 Rv1280c Rv1281c Rv1282c Rv1283c Rv2238c Rv2895c SLC11A1 TCIRG1 adhE2 ahpC ahpD bfr bfrB dlaT fgd1 ggtA glbN irtA irtB katG lpdC msrA secA1 secA2 secD secE secF secG secY sodB sodC tpx trx-2 trxA trxB +Leading Strand Synthesis Reactome Pathway PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 +Lectin pathway of complement activation Reactome Pathway FCN1 FCN2 FCN3 MASP1 MASP2 MBL2 +Leukotriene receptors Reactome Pathway CYSLTR1 CYSLTR2 GPR17 LTB4R LTB4R2 +Ligand-gated ion channel transport Reactome Pathway ARHGEF9 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GLRA1 GLRA2 GLRA3 GLRA4 GLRB HTR3A HTR3B HTR3C HTR3D HTR3E +Ligand-receptor interactions Reactome Pathway BOC CDON DHH GAS1 HHIP IHH PTCH1 SHH +Linoleic acid (LA) metabolism Reactome Pathway ABCD1 ACSL1 ELOVL2 ELOVL5 FADS1 FADS2 +Lipid digestion, mobilization, and transport Reactome Pathway A2M ABCA1 ABCG1 ABCG5 ABCG8 ABHD5 ALB AMN APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE APOF BMP1 CAV1 CEL CETP CLPS CUBN FABP4 HSPG2 LCAT LDLR LDLRAP1 LIPC LIPE LPA LPL MGLL MTTP NPC1L1 P4HB PLIN1 PLTP PNLIP PNLIPRP1 PNLIPRP2 PPP1CA PPP1CB PPP1CC PRKACA PRKACB PRKACG SAR1B SCARB1 SDC1 +Lipoprotein metabolism Reactome Pathway A2M ABCA1 ABCG1 ALB AMN APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE APOF BMP1 CETP CUBN HSPG2 LCAT LDLR LDLRAP1 LIPC LPA LPL MTTP P4HB PLTP SAR1B SCARB1 SDC1 +Localization of the PINCH-ILK-PARVIN complex to focal adhesions Reactome Pathway ILK ITGB1 PARVA PXN +Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Reactome Pathway CUL1 FBXW7 NOTCH1 RBX1 SKP1 +Loss of Function of SMAD2/3 in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Loss of Function of SMAD4 in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Loss of Function of TGFBR1 in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Loss of Function of TGFBR2 in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Loss of Nlp from mitotic centrosomes Reactome Pathway ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG +Loss of proteins required for interphase microtubule organization from the centrosome Reactome Pathway ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG +Lysine catabolism Reactome Pathway AADAT AASS ALDH7A1 DLD DLST GCDH OGDH SLC25A21 +Lysosome Vesicle Biogenesis Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 ARF1 ARRB1 BLOC1S1 CLTA CLTC CTSZ DNAJC6 DNASE2 DNM2 GNS HSPA8 M6PR SH3GL2 TXNDC5 VAMP2 VAMP7 VAMP8 +Lysosphingolipid and LPA receptors Reactome Pathway LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 +M Phase Reactome Pathway AAAS AHCTF1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANKLE2 APITD1 ARPP19 AURKB B9D2 BANF1 BIRC5 BLZF1 BUB1 BUB1B BUB3 CASC5 CCNB1 CCNB2 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA5 CDCA8 CDK1 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CNEP1R1 CSNK2A1 CSNK2A2 CSNK2B CTDNEP1 DSN1 EMD ENSA ERCC6L ESPL1 FBXO5 GOLGA2 GORASP1 GORASP2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC8 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 MAD1L1 MAD2L1 MAPK1 MAPK3 MAPRE1 MASTL MAU2 MCPH1 MIS12 NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 NDC80 NDE1 NDEL1 NEK6 NEK7 NEK9 NIPBL NSL1 NUDC NUF2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PAFAH1B1 PDS5A PDS5B PHF8 PLK1 PMF1 POM121 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2D PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKCA PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAB1A RAB1B RAB2A RAD21 RAE1 RANBP2 RANGAP1 RB1 RCC2 RPS27 RPS27A SEC13 SEH1L SET SETD8 SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC2 SMC3 SMC4 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 TMPO TPR UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 USO1 VRK1 VRK2 WAPAL XPO1 ZW10 ZWILCH ZWINT +M/G1 Transition Reactome Pathway CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 E2F1 E2F2 E2F3 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPA1 RPA2 RPA3 RPA4 RPS27A UBA52 UBB UBC +MAP kinase activation in TLR cascade Reactome Pathway ATF1 ATF2 CDK1 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RIPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 TAB1 TAB2 TAB3 TRAF6 TYK2 +MAPK targets/ Nuclear events mediated by MAP kinases Reactome Pathway ATF1 ATF2 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +MASTL Facilitates Mitotic Progression Reactome Pathway ARPP19 CCNB1 CDK1 ENSA MASTL PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2D +MEK activation Reactome Pathway HRAS KRAS MAP2K1 MAP2K2 NRAS RAF1 YWHAB +MHC class II antigen presentation Reactome Pathway ACTR1A ACTR1B AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 CANX CD74 CENPE CLTA CLTC CTSA CTSB CTSC CTSD CTSE CTSF CTSH CTSK CTSL CTSO CTSS CTSV DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DNM1 DNM2 DNM3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IFI30 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3A KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIFAP3 KLC1 KLC2 KLC3 KLC4 LGMN OSBPL1A RAB7A RACGAP1 RILP SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SH3GL2 SPTBN2 +MPS I - Hurler syndrome Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS II - Hunter syndrome Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IIIA - Sanfilippo syndrome A Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IIIB - Sanfilippo syndrome B Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IIIC - Sanfilippo syndrome C Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IIID - Sanfilippo syndrome D Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IV - Morquio syndrome A Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IV - Morquio syndrome B Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS IX - Natowicz syndrome Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS VI - Maroteaux-Lamy syndrome Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MPS VII - Sly syndrome Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +MRN complex relocalizes to nuclear foci Reactome Pathway H2AFX MRE11A NBN RAD50 +Meiosis Reactome Pathway ACD ATM ATR BLM BRCA1 BRCA2 CDK2 CDK4 DIDO1 DMC1 FKBP6 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HSPA2 LMNA LMNB1 MLH1 MLH3 MND1 MRE11A MSH4 MSH5 NBN POT1 PRDM9 PSMC3IP RAD21 RAD50 RAD51 RAD51C RBBP8 REC8 RPA1 RPA2 RPA3 SMC1A SMC1B SMC3 SPO11 STAG1 STAG2 STAG3 SUN1 SUN2 SYCE1 SYCE2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TEX15 TINF2 TOP3A UBE2I +Meiotic recombination Reactome Pathway ATM BLM BRCA1 BRCA2 CDK2 CDK4 DMC1 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 MLH1 MLH3 MND1 MRE11A MSH4 MSH5 NBN PRDM9 PSMC3IP RAD50 RAD51 RAD51C RBBP8 RPA1 RPA2 RPA3 SPO11 TEX15 TOP3A +Meiotic synapsis Reactome Pathway ACD ATR BRCA1 DIDO1 FKBP6 H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 HSPA2 LMNA LMNB1 POT1 RAD21 REC8 SMC1A SMC1B SMC3 STAG1 STAG2 STAG3 SUN1 SUN2 SYCE1 SYCE2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TINF2 UBE2I +Membrane Trafficking Reactome Pathway AKT1 AKT2 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2M1 AP3B1 AP3S1 AP4B1 AP4E1 ARCN1 ARF1 ARFGAP1 ARRB1 ASPSCR1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 C2CD5 CALM1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CLINT1 CLTA CLTB CLTC CLTCL1 COPA COPB1 COPB2 COPE COPG1 COPZ1 CPD CTSZ DAB2 DNAJC6 DNASE2 DNM1 DNM2 DTNBP1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 FTH1 FTL GAK GBF1 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 GNS HGS HIP1R HSPA8 IGF2R KIF3A KIF3B KIFAP3 LNPEP M6PR MYH1 MYH13 MYH15 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYO1C MYO5A MYO6 NAPA NECAP1 OCRL PICALM PIK3C2A PREB PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PUM1 RAB10 RAB11A RAB13 RAB14 RAB4A RAB5C RAB8A RAC1 RALA RALGAPA2 RALGAPB RHOQ RPS27A SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SFN SH3D19 SH3GL2 SLC2A4 SNAP23 SNAPIN SNF8 SNX2 SNX5 SNX9 SORT1 SRC STAM STAM2 STX4 STXBP3 TBC1D1 TBC1D4 TBC1D8B TFRC TGOLN2 TJP1 TPD52 TPD52L1 TSG101 TXNDC5 UBA52 UBB UBC VAMP2 VAMP7 VAMP8 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 YIPF6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Membrane binding and targetting of GAG proteins Reactome Pathway NMT2 RPS27A TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D gag +Metabolic disorders of biological oxidation enzymes Reactome Pathway ACKR1 ACKR2 ACKR3 ACKR4 ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 ACSS1 ACSS2 ACY1 ACY3 ADCYAP1 ADCYAP1R1 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 AHCY AKR7A2 AKR7A3 AKR7L ALDH1A1 ALDH2 ANXA1 APLN APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BPNT1 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CASR CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD55 CD97 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNDP2 CNR1 CNR2 COMT CRH CRHR1 CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 CYSLTR1 CYSLTR2 DHH DPEP1 DPEP2 DPEP3 DRD1 DRD2 DRD3 DRD4 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FDX1 FDX1L FDXR FFAR1 FFAR2 FFAR3 FFAR4 FMO1 FMO2 FMO3 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GCG GCGR GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GLYAT GLYATL1 GLYATL2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HPGDS HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAOA MAOB MAT1A MAT2A MAT2B MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MGST1 MGST2 MGST3 MLN MLNR MT-RNR2 MTNR1A MTNR1B MTR MTRR NAT1 NAT2 NCOA1 NCOA2 NMB NMBR NMS NMU NMUR1 NMUR2 NNMT NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NR1H4 NTS NTSR1 NTSR2 OPLAH OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PAOX PAPSS1 PAPSS2 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTCH1 PTCH2 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTGIS PTGS1 PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 RXRA S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SMO SMOX SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TBXAS1 TPMT TRH TRHR TSHB TSHR UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UTS2 UTS2B UTS2R WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 +Metabolism Reactome Pathway A2M AAAS AADAT AANAT AASDHPPT AASS ABCA1 ABCB1 ABCB11 ABCB4 ABCB7 ABCC1 ABCC3 ABCC5 ABCC8 ABCD1 ABCD4 ABCG1 ABCG2 ABCG5 ABCG8 ABHD5 ACAA1 ACACA ACACB ACAD8 ACADL ACADM ACADS ACADSB ACADVL ACAN ACAT1 ACER1 ACER2 ACER3 ACHE ACLY ACMSD ACO2 ACOT8 ACOX1 ACOX2 ACOX3 ACP5 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 ACSS1 ACSS2 ACY1 ACY3 ADA ADAL ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ADHFE1 ADI1 ADK ADRA2A ADRA2C ADSL ADSS ADSSL1 AFMID AGL AGMAT AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 AGPS AGRN AGT AGXT AGXT2 AHCY AK1 AK2 AK5 AKAP5 AKR1B1 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AKR7A2 AKR7A3 AKR7L AKT1 ALAD ALAS1 ALAS2 ALB ALDH18A1 ALDH1A1 ALDH2 ALDH4A1 ALDH6A1 ALDH7A1 ALDH9A1 ALDOA ALDOB ALDOC ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 ALOX5AP AMACR AMD1 AMDHD1 AMN AMPD1 AMPD2 AMPD3 AMY1A AMY1B AMY2A AMY2B ANGPTL4 ANKRD1 AOX1 APIP APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE APOF APRT AQP1 ARF1 ARF3 ARG1 ARG2 ARNTL ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C ASL ASMT ASNS ASS1 ATIC ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP5S AUH AZIN1 AZIN2 B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BAAT BBOX1 BCAN BCAT1 BCAT2 BCHE BCKDHA BCKDHB BDH1 BGN BHMT BLVRA BLVRB BMP1 BPNT1 BRIP1 BSG BTD CA1 CA12 CA13 CA14 CA2 CA3 CA4 CA5A CA5B CA6 CA7 CA9 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CAD CALM1 CARM1 CAT CAV1 CBR1 CBS CCBL1 CCBL2 CCNC CD320 CD36 CD44 CDA CDIPT CDK19 CDK8 CDO1 CDS1 CDS2 CEL CEPT1 CERK CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CETP CGA CH25H CHAT CHD9 CHKA CHKB CHP1 CHPF CHPF2 CHPT1 CHRM3 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CIAO1 CIAPIN1 CKB CKM CKMT1A CKMT2 CLOCK CLPS CMPK1 CNDP2 COASY COL4A3BP COMT COQ2 COQ3 COQ5 COQ6 COQ7 COX10 COX11 COX14 COX15 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CPOX CPS1 CPT1A CPT1B CPT2 CRAT CREBBP CRLS1 CROT CS CSAD CSGALNACT1 CSGALNACT2 CSNK1G2 CSPG4 CSPG5 CTGF CTH CTPS1 CTPS2 CTRB1 CTRB2 CTSA CUBN CYB5A CYB5R3 CYC1 CYCS CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 D2HGDH DAO DBH DBT DCK DCN DCTD DDC DECR1 DEGS1 DEGS2 DGAT1 DGAT2 DGUOK DHCR24 DHCR7 DHFR DHFRL1 DHODH DIO1 DIO2 DIO3 DLAT DLD DLST DNM2 DPEP1 DPEP2 DPEP3 DPYD DPYS DSE DSEL DTYMK DUT EBP ECHS1 ECI1 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 ENO1 ENO2 ENO3 ENOPH1 ENPP1 ENPP7 EP300 EPHX2 EPM2A EPT1 ERCC2 ESRRA ETFA ETFB ETFDH ETHE1 ETNK1 ETNK2 EXT1 EXT2 FABP1 FABP4 FABP6 FADS1 FADS2 FAH FAM213B FAM96B FAR1 FAR2 FASN FBP1 FBP2 FDFT1 FDPS FDX1 FDX1L FDXR FECH FFAR1 FH FHL2 FIG4 FLAD1 FMO1 FMO2 FMO3 FMOD FPGS FTCD FXN G0S2 G6PC G6PC2 G6PC3 G6PD GALC GALE GALK1 GALT GAMT GAPDH GAPDHS GART GATM GBA GBA2 GBA3 GBE1 GC GCDH GCG GCGR GCH1 GCHFR GCK GCKR GCLC GCLM GDA GGCT GGPS1 GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GIF GK GK2 GK3P GLA GLB1 GLB1L GLCE GLIPR1 GLP1R GLRX GLS GLS2 GLUD1 GLUL GLYAT GLYATL1 GLYATL2 GM2A GMPR GMPR2 GMPS GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNPAT GNS GOT1 GOT2 GPAM GPAT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPCPD1 GPD1 GPD1L GPD2 GPHN GPI GPT GPT2 GPX1 GPX2 GPX4 GRHL1 GRHPR GSR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 GUK1 GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 HAAO HACL1 HADH HADHA HADHB HAL HAO1 HAS1 HAS2 HAS3 HBA1 HBB HDAC3 HDC HELZ2 HEXA HEXB HGD HIBADH HIBCH HK1 HK2 HK3 HLCS HMBS HMGCL HMGCR HMGCS1 HMGCS2 HMMR HMOX1 HMOX2 HPD HPGD HPGDS HPRT1 HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSD11B1 HSD17B1 HSD17B10 HSD17B12 HSD17B3 HSD17B4 HSD17B7 HSD3B1 HSD3B2 HSD3B7 HSP90AA1 HSPG2 HYAL1 HYAL2 HYAL3 IDH1 IDH2 IDH3A IDH3B IDH3G IDI1 IDI2 IDO1 IDO2 IDS IDUA IMPA1 IMPA2 IMPDH1 IMPDH2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5D INPP5E INPP5J INPP5K INPPL1 INS INSIG1 INSIG2 IP6K1 IP6K2 IP6K3 IPMK IPPK IQGAP1 ISCU ISYNA1 ITPA ITPK1 ITPKA ITPKB ITPKC ITPR1 ITPR2 ITPR3 IVD IYD KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 KDSR KERA KHK KMO KPNB1 KYNU L2HGDH LBR LCAT LCLAT1 LCT LDHA LDHB LDLR LDLRAP1 LGMN LHB LIPC LIPE LMBRD1 LPA LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 LPL LRP2 LRPPRC LSS LTA4H LTC4S LUM LYPLA1 LYRM4 LYVE1 MAOA MAOB MAPKAPK2 MARCKS MAT1A MAT2A MAT2B MBOAT1 MBOAT2 MBOAT7 MBTPS1 MBTPS2 MCCC1 MCCC2 MCEE MDH1 MDH2 ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MGAM MGLL MGST1 MGST2 MGST3 MINPP1 MLX MLXIPL MLYCD MMAA MMAB MMACHC MMADHC MMS19 MOCOS MOCS1 MOCS2 MOCS3 MPC1 MPC2 MRI1 MSMO1 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2 MT-CO3 MT-CYB MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 MTAP MTHFD1 MTHFR MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 MTR MTRR MTTP MUT MVD MVK NADK NADSYN1 NAGLU NAGS NAMPT NAPRT NARFL NAT1 NAT2 NCAN NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NDOR1 NDST1 NDST2 NDST3 NDST4 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NEU1 NEU2 NEU3 NEU4 NFS1 NFYA NFYB NFYC NHLRC1 NME1 NME2 NME4 NMNAT1 NMNAT2 NMNAT3 NNMT NNT NOS3 NOSIP NOSTRIN NPAS2 NPC1L1 NQO1 NR1D1 NR1H4 NRF1 NSDHL NT5C NT5C1A NT5C1B NT5C2 NT5C3A NT5E NT5M NUBP1 NUBP2 NUDT1 NUDT10 NUDT11 NUDT15 NUDT16 NUDT18 NUDT3 NUDT4 NUDT5 NUDT9 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OAT OAZ1 OAZ2 OAZ3 OCRL ODC1 OGDH OGN OMD OPLAH OSBP OTC OXCT1 P4HB PAH PAICS PANK1 PANK2 PANK3 PANK4 PAOX PAPSS1 PAPSS2 PC PCBD1 PCCA PCCB PCK1 PCK2 PCYT1A PCYT1B PCYT2 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PDSS1 PDSS2 PDXK PDZD11 PEMT PEX11A PFAS PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PGS1 PHGDH PHKA1 PHKA2 PHKB PHKG1 PHKG2 PHOSPHO1 PHYH PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PISD PITPNB PKLR PKM PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLB1 PLBD1 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD1 PLD2 PLD3 PLD4 PLD6 PLIN1 PLIN2 PLTP PMVK PNLIP PNLIPRP1 PNLIPRP2 PNMT PNP PNPLA2 PNPLA3 PNPLA8 PNPO POLD1 POM121 POMC PPAP2A PPAP2B PPAP2C PPARA PPARD PPARG PPARGC1A PPARGC1B PPAT PPCDC PPCS PPIP5K1 PPIP5K2 PPM1L PPOX PPP1CA PPP1CB PPP1CC PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKD1 PRKG2 PRODH PRPS1 PRPS1L1 PRPS2 PRSS1 PRSS3 PSAP PSAT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PSPH PTDSS1 PTDSS2 PTEN PTGDS PTGES PTGES3 PTGIS PTGR1 PTGS1 PTGS2 PTPMT1 PTS PYCR1 PYGB PYGL PYGM QDPR QPRT RAE1 RAN RANBP2 RAP1A RAPGEF3 RAPGEF4 RFK RGL1 RHAG RORA RPE RPIA RPS27A RRM1 RRM2 RRM2B RTEL1 RXRA SACM1L SAR1B SAT1 SC5D SC5DL SCAP SCARB1 SCO1 SCO2 SCP2 SDC1 SDC2 SDC3 SDC4 SDHA SDHB SDHC SDHD SEC23A SEC24A SEC24B SEC24C SEC24D SEH1L SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SGSH SHMT1 SI SIN3A SIN3B SLC10A1 SLC10A2 SLC16A1 SLC16A3 SLC16A8 SLC19A1 SLC19A2 SLC19A3 SLC22A1 SLC22A2 SLC22A3 SLC23A1 SLC23A2 SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A15 SLC25A16 SLC25A17 SLC25A2 SLC25A20 SLC25A21 SLC25A28 SLC25A32 SLC25A37 SLC25A4 SLC25A5 SLC25A6 SLC26A1 SLC26A2 SLC27A1 SLC27A2 SLC27A5 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC35B2 SLC35B3 SLC35D1 SLC35D2 SLC37A4 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC46A1 SLC4A1 SLC52A3 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A9 SLC6A11 SLC6A12 SLC6A7 SLC6A8 SLC9A1 SLCO1A2 SLCO1B1 SLCO1B3 SMARCD3 SMOX SMPD1 SMPD2 SMPD3 SMPD4 SMS SNAP25 SP1 SPHK1 SPHK2 SPR SPTLC1 SPTLC2 SPTLC3 SQLE SQRDL SRD5A1 SRD5A2 SRD5A3 SREBF1 SREBF2 SRM ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 STAR STARD4 STARD5 STARD6 STK11 STS STX1A STXBP1 SUCLA2 SUCLG1 SUCLG2 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SUMF1 SUMF2 SUOX SURF1 SYNJ1 SYNJ2 SYT5 TACO1 TALDO1 TAT TAZ TBL1X TBL1XR1 TBXAS1 TCN1 TCN2 TDO2 TEAD1 TEAD2 TEAD3 TEAD4 TECR TECRL TGS1 TH THTPA TIAM2 TK1 TK2 TKT TM7SF2 TMLHE TNFRSF21 TPH1 TPH2 TPI1 TPK1 TPMT TPO TPR TPTE TPTE2 TREH TRIB3 TSHB TST TXN TXNRD1 TYMP TYMS UBA52 UBB UBC UCK1 UCK2 UCP1 UCP2 UCP3 UGCG UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UMPS UPB1 UPP1 UPP2 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ UROC1 UROD UROS UST VAC14 VAMP2 VAPA VAPB VCAN WASL WWTR1 XDH YAP1 ZDHHC21 +Metabolism of Angiotensinogen to Angiotensins Reactome Pathway ACE ACE2 AGT ANPEP ATP6AP2 CMA1 CPA3 CPB1 CPB2 CTSD CTSG CTSZ ENPEP GZMH MME REN +Metabolism of amino acids and derivatives Reactome Pathway AADAT AANAT AASS ACAD8 ACADSB ACAT1 ACMSD ADI1 AFMID AGMAT AGXT AGXT2 AHCY ALDH18A1 ALDH4A1 ALDH6A1 ALDH7A1 ALDH9A1 AMD1 AMDHD1 APIP ARG1 ARG2 ASL ASMT ASNS ASS1 AUH AZIN1 AZIN2 BBOX1 BCAT1 BCAT2 BCKDHA BCKDHB BHMT CBS CCBL1 CCBL2 CDO1 CGA CKB CKM CKMT1A CKMT2 CNDP2 CPS1 CSAD CTH DAO DBH DBT DDC DIO1 DIO2 DIO3 DLD DLST ENOPH1 ETHE1 FAH FTCD GAMT GATM GCDH GCLC GCLM GLS GLS2 GLUD1 GLUL GOT1 GOT2 GPT GPT2 GRHPR GSTZ1 HAAO HAL HAO1 HDC HGD HIBADH HIBCH HPD HSD17B10 IDO1 IDO2 IVD IYD KMO KYNU MAT1A MCCC1 MCCC2 MRI1 MTAP MTR MTRR NAGS NQO1 OAT OAZ1 OAZ2 OAZ3 ODC1 OGDH OTC PAH PAOX PCBD1 PHGDH PNMT PRODH PSAT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PSPH PYCR1 QDPR SAT1 SHMT1 SLC25A10 SLC25A15 SLC25A2 SLC25A21 SLC5A5 SLC6A11 SLC6A12 SLC6A7 SLC6A8 SMOX SMS SQRDL SRM SUOX TAT TDO2 TH TMLHE TPH1 TPH2 TPO TSHB TST UROC1 +Metabolism of carbohydrates Reactome Pathway AAAS ABCC5 ACAN AGL AGRN ALDOA ALDOB ALDOC AMY1A AMY1B AMY2A AMY2B ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CALM1 CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL ENO1 ENO2 ENO3 EPM2A EXT1 EXT2 FBP1 FBP2 FMOD G6PC G6PC2 G6PC3 G6PD GALE GALK1 GALT GAPDH GAPDHS GBE1 GCK GCKR GLB1 GLB1L GLCE GNS GOT1 GOT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPI GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 HAS1 HAS2 HAS3 HEXA HEXB HK1 HK2 HK3 HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA KHK LCT LUM LYVE1 MDH1 MDH2 MGAM NAGLU NCAN NDST1 NDST2 NDST3 NDST4 NHLRC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OGN OMD PAPSS1 PAPSS2 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM POM121 PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKACA PRKACB PRKACG PRPS1 PRPS1L1 PRPS2 PYGB PYGL PYGM RAE1 RANBP2 RPE RPIA RPS27A SDC1 SDC2 SDC3 SDC4 SEH1L SGSH SI SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC26A1 SLC26A2 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC35B2 SLC35B3 SLC35D2 SLC37A4 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A9 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 TALDO1 TKT TPI1 TPR TREH UBA52 UBB UBC UGP2 UST VCAN +Metabolism of folate and pterines Reactome Pathway DHFR DHFRL1 FPGS MTHFD1 MTHFR SHMT1 SLC19A1 SLC25A32 SLC46A1 +Metabolism of lipids and lipoproteins Reactome Pathway A2M ABCA1 ABCB11 ABCB4 ABCC1 ABCC3 ABCD1 ABCG1 ABCG5 ABCG8 ABHD5 ACAA1 ACACA ACACB ACADL ACADM ACADS ACADVL ACAT1 ACER1 ACER2 ACER3 ACHE ACLY ACOT8 ACOX1 ACOX2 ACOX3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 AGPS AGT AKR1B1 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 ALAS1 ALB ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 ALOX5AP AMACR AMN ANGPTL4 ANKRD1 APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE APOF ARF1 ARF3 ARNTL ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C BAAT BCHE BDH1 BMP1 CARM1 CAV1 CBR1 CCNC CD36 CDIPT CDK19 CDK8 CDS1 CDS2 CEL CEPT1 CERK CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CETP CGA CH25H CHAT CHD9 CHKA CHKB CHPT1 CLOCK CLPS COL4A3BP COQ2 COQ3 COQ5 COQ6 COQ7 CPT1A CPT1B CPT2 CRAT CREBBP CRLS1 CROT CSNK1G2 CTGF CTSA CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP27A1 CYP27B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP2R1 CYP2U1 CYP39A1 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 DECR1 DEGS1 DEGS2 DGAT1 DGAT2 DHCR24 DHCR7 DPEP1 DPEP2 DPEP3 EBP ECHS1 ECI1 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 ENPP7 EP300 EPHX2 EPT1 ESRRA ETNK1 ETNK2 FABP1 FABP4 FABP6 FADS1 FADS2 FAM213B FAR1 FAR2 FASN FDFT1 FDPS FDX1 FDX1L FDXR FHL2 FIG4 G0S2 GALC GBA GBA2 GBA3 GC GGPS1 GGT1 GGT5 GK GK2 GK3P GLA GLB1 GLB1L GLIPR1 GM2A GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L GPD2 GPX1 GPX2 GPX4 GRHL1 HACL1 HADH HADHA HADHB HDAC3 HELZ2 HEXA HEXB HMGCL HMGCR HMGCS1 HMGCS2 HPGD HPGDS HSD11B1 HSD17B1 HSD17B12 HSD17B3 HSD17B4 HSD17B7 HSD3B1 HSD3B2 HSD3B7 HSPG2 IDH1 IDI1 IDI2 INPP4A INPP4B INPP5D INPP5E INPP5J INPP5K INPPL1 INSIG1 INSIG2 KDSR KPNB1 LBR LCAT LCLAT1 LDLR LDLRAP1 LGMN LHB LIPC LIPE LPA LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 LPL LRP2 LSS LTA4H LTC4S MAPKAPK2 MBOAT1 MBOAT2 MBOAT7 MBTPS1 MBTPS2 MCEE ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MGLL MLYCD MMAA MSMO1 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 MTTP MUT MVD MVK NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NEU1 NEU2 NEU3 NEU4 NFYA NFYB NFYC NPAS2 NPC1L1 NR1D1 NR1H4 NRF1 NSDHL OCRL OSBP OXCT1 P4HB PCCA PCCB PCYT1A PCYT1B PCYT2 PDSS1 PDSS2 PEMT PEX11A PGS1 PHOSPHO1 PHYH PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PISD PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLB1 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PLIN1 PLIN2 PLTP PMVK PNLIP PNLIPRP1 PNLIPRP2 PNPLA2 PNPLA3 PNPLA8 POMC PPAP2A PPAP2B PPAP2C PPARA PPARD PPARG PPARGC1A PPARGC1B PPM1L PPP1CA PPP1CB PPP1CC PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKD1 PSAP PTDSS1 PTDSS2 PTEN PTGDS PTGES PTGES3 PTGIS PTGR1 PTGS1 PTGS2 PTPMT1 RAN RGL1 RORA RXRA SACM1L SAR1B SC5D SC5DL SCAP SCARB1 SCP2 SDC1 SEC23A SEC24A SEC24B SEC24C SEC24D SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SIN3A SIN3B SLC10A1 SLC10A2 SLC25A1 SLC25A17 SLC25A20 SLC27A1 SLC27A2 SLC27A5 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLCO1A2 SLCO1B1 SLCO1B3 SMARCD3 SMPD1 SMPD2 SMPD3 SMPD4 SP1 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3 SQLE SRD5A1 SRD5A2 SRD5A3 SREBF1 SREBF2 STAR STARD4 STARD5 STARD6 STS SULT2A1 SUMF1 SUMF2 SYNJ1 SYNJ2 TAZ TBL1X TBL1XR1 TBXAS1 TEAD1 TEAD2 TEAD3 TEAD4 TECR TECRL TGS1 TIAM2 TM7SF2 TNFRSF21 TPTE TPTE2 TRIB3 TXNRD1 UGCG UGT1A9 VAC14 VAPA VAPB WWTR1 YAP1 +Metabolism of nitric oxide Reactome Pathway AKT1 CALM1 CAV1 DHFR DNM2 GCH1 GCHFR HSP90AA1 LYPLA1 NOS3 NOSIP NOSTRIN PRKG2 PTS SPR WASL ZDHHC21 +Metabolism of non-coding RNA Reactome Pathway AAAS CLNS1A DDX20 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PHAX POM121 PRMT5 RAE1 RANBP2 SEH1L SMN1 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN TGS1 TPR WDR77 +Metabolism of nucleotides Reactome Pathway ADA ADAL ADK ADSL ADSS ADSSL1 AGXT2 AK1 AK2 AK5 AMPD1 AMPD2 AMPD3 APRT ATIC CAD CAT CDA CMPK1 CTPS1 CTPS2 DCK DCTD DGUOK DHODH DPYD DPYS DTYMK DUT GART GDA GLRX GMPR GMPR2 GMPS GPX1 GSR GUK1 HPRT1 IMPDH1 IMPDH2 ITPA NME1 NME2 NME4 NT5C NT5C1A NT5C1B NT5C2 NT5C3A NT5E NT5M NUDT1 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 PAICS PFAS PNP PPAT RRM1 RRM2 RRM2B TK1 TK2 TXN TXNRD1 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 XDH +Metabolism of polyamines Reactome Pathway ADI1 AGMAT AMD1 APIP AZIN2 ENOPH1 GOT1 MRI1 MTAP ODC1 PAOX SAT1 SMOX SMS SRM +Metabolism of porphyrins Reactome Pathway ALAD ALAS1 ALAS2 BLVRA BLVRB COX10 COX15 CPOX FECH HMBS HMOX1 HMOX2 PPOX UGT1A1 UGT1A4 UROD UROS +Metabolism of proteins Reactome Pathway 7SL RNA (ENSG00000222619) 7SL RNA (ENSG00000222639) ACADVL ACE ACE2 ACHE ACO2 ACTB ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADD1 AGT ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ANPEP AP3M1 ARFGAP1 ARFGEF2 ARL2 ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASNS ATF3 ATF4 ATF6 ATP5A1 ATP5B ATP5G1 ATP6AP2 ATP6V0D1 ATPV0D1 B3GALTL B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 BCHE BCS1L C19orf10 C1GALT1 C1GALT1C1 CALR CANX CCL2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CDX2 CFP CGA CGB CHCHD4 CMA1 CMAS COQ2 COX17 CPA3 CPB1 CPB2 CPE CPN1 CS CTDSP2 CTNNB1 CTSA CTSD CTSG CTSZ CUL7 CXCL8 CXXC1 CYC1 DAD1 DCP2 DCTN1 DDIT3 DDOST DDX11 DHDDS DHPS DIS3 DNAJB11 DNAJB9 DNAJC19 DNAJC24 DNAJC3 DOHH DOLK DOLPP1 DPAGT1 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 DPM1 DPM2 DPM3 DPP4 EDEM1 EDEM2 EDEM3 EEF1A1 EEF1A1P5 EEF1A2 EEF1B2 EEF1D EEF1G EEF2 EIF1AX EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5A EIF5A2 EIF5B ENPEP ERN1 ERO1L ERO1LB ETF1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXTL3 F10 F2 F7 F9 FAU FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FFAR1 FFAR4 FKBP14 FKBP14 gene FKBP9 FSHB FURIN FUT8 FXN GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT18 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL5 GALNTL6 GANAB GAS6 GATA4 GCG GCNT1 GCNT3 GCNT4 GCNT6 GCNT7 GFER GFPT1 GFPT2 GGCX GH1 GHRL GIP GLB1 GMPPA GMPPB GNAT3 GNB3 GNE GNG13 GNPNAT1 GOSR2 GPAA1 GPR119 GRP GRPEL1 GRPEL2 GSK3A GSPT2 GZMH HDGF HERPUD1 HSCB HSP90B1 HSPA5 HSPA9 HSPD1 HYOU1 IDH3G IGF1 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IL8 INHA INHBA INHBB INHBC INHBE INS ISL1 KDELR3 KHSRP KIF13A KIF5A KIF5B KIF5C KIFC3 KLF4 KLHDC3 KLK1 KLK13 KLK2 KLK3 LDHD LEP LHB LMAN1 LMNA LONP2 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MBOAT4 MBTPS1 MBTPS2 MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MME MMP1 MMP2 MOGS MPDU1 MPI MTX1 MTX2 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 MVD MYO5A NANP NANS NEU1 NEU2 NEU3 NEU4 NFYA NFYB NFYC NOP56 NPL PABPC1 PAM16 PAPPA PAPPA2 PARN PAX6 PCSK1 PCSK2 PDIA3 PDIA5 PDIA6 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 PGAP1 PGM3 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLA2G4B PLA2G7 PLAUR PLG PMM1 PMM2 PMPCA PMPCB POFUT2 POMC PPP2R5B PREB PRKCSH PROC PROS1 PROZ RAB27A REN RFT1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SAE1 SAMM50 SAR1B SBSPON SEC11A SEC11C SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SEMA5A SEMA5B SENP1 SENP2 SENP5 SERP1 SHC1 SKIV2L SLC17A5 SLC25A12 SLC25A13 SLC25A4 SLC25A6 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC35A1 SPCS1 SPCS2 SPCS3 SPHK1 SPON1 SPON2 SRD5A3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRPR SRPRB SSPO SSR1 SSR2 SSR3 SSR4 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STS STT3A STX1A SULT1A3 SUMF1 SUMF2 SUMO1 SUMO2 SUMO3 SYVN1 TATDN2 TAZ TBCA TBCB TBCC TBCD TBCE TCF7L2 TCP1 THBS1 THBS2 THSD1 THSD4 THSD7A THSD7B TIMM10 TIMM10B TIMM13 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TLN1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70A TPP1 TRAM1 TSHB TSPYL2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUSC3 UAP1 UBA2 UBA52 UBE2I UGGT1 UGGT2 USP11 VAMP2 VBP1 VDAC1 VKORC1 WBSCR17 WFS1 WIPI1 XBP1 XRN2 YIF1A ZBTB17 +Metabolism of serotonin Reactome Pathway ALDH2 MAOA +Metabolism of steroid hormones and vitamin D Reactome Pathway AKR1B1 CGA CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 CYP24A1 CYP27B1 CYP2R1 FDX1 FDX1L FDXR GC HSD11B1 HSD17B1 HSD17B12 HSD17B3 HSD3B1 HSD3B2 LGMN LHB LRP2 POMC SRD5A1 SRD5A2 SRD5A3 STAR STARD4 STARD5 STARD6 +Metabolism of vitamins and cofactors Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Metabolism of water-soluble vitamins and cofactors Reactome Pathway AASDHPPT ABCC1 ABCD4 ACACA ACACB ACP5 AMN AOX1 BTD CD320 COASY CTRB1 CTRB2 CUBN CYB5A CYB5R3 CYP8B1 DHFR DHFRL1 ENPP1 FASN FLAD1 FPGS GIF GPHN GSTO1 GSTO2 HLCS LMBRD1 MCCC1 MCCC2 MMAA MMAB MMACHC MMADHC MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR MTR MTRR MUT NADK NADSYN1 NAMPT NAPRT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PC PCCA PCCB PDXK PDZD11 PNPO PPCDC PPCS PRSS1 PRSS3 PTGIS PTGS2 QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC52A3 SLC5A6 TCN1 TCN2 THTPA TPK1 +Metal ion SLC transporters Reactome Pathway CP HEPH SLC11A1 SLC11A2 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC31A1 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC40A1 SLC41A1 SLC41A2 +Methionine salvage pathway Reactome Pathway ADI1 APIP ENOPH1 GOT1 MRI1 MTAP +Methylation Reactome Pathway AHCY COMT CYP1A2 MAT1A MAT2A MAT2B MTR MTRR NNMT TPMT +MicroRNA (miRNA) biogenesis Reactome Pathway AGO1 AGO2 AGO3 AGO4 DGCR8 DICER1 DROSHA POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRKRA RAN TARBP2 XPO5 +Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Reactome Pathway GJA1 +Mineralocorticoid biosynthesis Reactome Pathway CGA CYP11B2 CYP21A2 HSD3B1 HSD3B2 LHB +Minus-strand DNA synthesis Reactome Pathway PPIA gag gag-pol rev vif vpr vpu +Miscellaneous substrates Reactome Pathway CYP2D6 CYP2S1 CYP2U1 CYP2W1 CYP3A43 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 +Mismatch Repair Reactome Pathway APEX1 EXO1 LIG1 MLH1 MSH2 MSH3 MSH6 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Reactome Pathway APEX1 EXO1 LIG1 MLH1 MSH2 MSH3 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Reactome Pathway APEX1 EXO1 LIG1 MLH1 MSH2 MSH6 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +Mitochondrial ABC transporters Reactome Pathway ABCB10 ABCB6 ABCB7 ABCB8 +Mitochondrial Fatty Acid Beta-Oxidation Reactome Pathway ACADL ACADM ACADS ACADVL DECR1 ECHS1 ECI1 HADH HADHA HADHB MCEE MMAA MUT PCCA PCCB +Mitochondrial Uncoupling Proteins Reactome Pathway UCP1 UCP2 UCP3 +Mitochondrial biogenesis Reactome Pathway ALAS1 ATF2 ATP5B CALM1 CAMK4 CARM1 CHD9 CREB1 CREBBP CYCS ESRRA GABPA GABPB1 HCFC1 HDAC3 HELZ2 MAPK11 MAPK12 MAPK14 MED1 MEF2C MEF2D MTERF MTERF1 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRF1 PEO1 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPRC1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RXRA SIRT3 SMARCD3 SSBP1 TBL1X TBL1XR1 TFAM TFB1M TFB2M TGS1 +Mitochondrial iron-sulfur cluster biogenesis Reactome Pathway FDX1 FDX1L FDXR FXN ISCU LYRM4 NFS1 SLC25A28 SLC25A37 +Mitochondrial protein import Reactome Pathway ACO2 ATP5A1 ATP5B ATP5G1 BCS1L CHCHD4 COQ2 COX17 CS CYC1 DNAJC19 FXN GFER GRPEL1 GRPEL2 HSCB HSPA9 HSPD1 IDH3G LDHD MTX1 MTX2 PAM16 PMPCA PMPCB SAMM50 SLC25A12 SLC25A13 SLC25A4 SLC25A6 TAZ TIMM10 TIMM10B TIMM13 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70A VDAC1 +Mitochondrial tRNA aminoacylation Reactome Pathway AARS2 CARS2 DARS2 EARS2 FARS2 GARS HARS2 IARS2 KARS LARS2 MARS2 NARS2 PARS2 PPA2 QARS RARS2 SARS2 TARS2 VARS2 WARS2 YARS2 +Mitochondrial transcription initiation Reactome Pathway POLRMT TFAM TFB2M +Mitochondrial transcription termination Reactome Pathway MTERF1 +Mitochondrial translation Reactome Pathway AURKAIP1 CHCHD1 DAP3 GADD45GIP1 GFM1 GFM2 ICT1 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51 MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS6 MRPS7 MRPS9 MRRF MT-RNR1 MT-RNR2 MTFMT MTIF2 MTIF3 MTRF1L PTCD3 TSFM TUFM +Mitochondrial translation elongation Reactome Pathway AURKAIP1 CHCHD1 DAP3 GADD45GIP1 GFM1 ICT1 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51 MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS6 MRPS7 MRPS9 MT-RNR1 MT-RNR2 PTCD3 TSFM TUFM +Mitochondrial translation initiation Reactome Pathway AURKAIP1 CHCHD1 DAP3 GADD45GIP1 ICT1 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51 MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS6 MRPS7 MRPS9 MT-RNR1 MT-RNR2 MTFMT MTIF2 MTIF3 PTCD3 +Mitochondrial translation termination Reactome Pathway AURKAIP1 CHCHD1 DAP3 GADD45GIP1 GFM2 ICT1 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51 MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS6 MRPS7 MRPS9 MRRF MT-RNR1 MT-RNR2 MTRF1L PTCD3 +Mitotic Anaphase Reactome Pathway AHCTF1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANKLE2 APITD1 AURKB B9D2 BANF1 BIRC5 BUB1 BUB1B BUB3 CASC5 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA5 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 EMD ERCC6L ESPL1 HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 LEMD2 LEMD3 LMNA LMNB1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAD21 RANBP2 RANGAP1 RCC2 RPS27 RPS27A SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC3 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 TMPO UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 VRK1 VRK2 WAPAL XPO1 ZW10 ZWILCH ZWINT +Mitotic G1-G1/S phases Reactome Pathway CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CKS1B CUL1 DBF4 DHFR DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 FBXO5 HDAC1 LIN37 LIN52 LIN54 LIN9 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYBL2 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 POLA1 POLA2 POLE POLE2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RB1 RBBP4 RBL1 RBL2 RPA1 RPA2 RPA3 RPA4 RPS27A RRM2 SKP1 SKP2 TFDP1 TFDP2 TK2 TOP2A TYMS UBA52 UBB UBC WEE1 +Mitotic G2-G2/M phases Reactome Pathway ACTR1A AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNA1 CCNA2 CCNB1 CCNB2 CCNH CCP110 CDC25A CDC25B CDC25C CDK1 CDK11A CDK11B CDK2 CDK5RAP2 CDK7 CENPF CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 E2F1 E2F3 EP300 FBXW11 FGFR1OP FOXM1 HAUS2 HSP90AA1 LIN37 LIN52 LIN54 LIN9 MAPRE1 MNAT1 MYBL2 NDE1 NEDD1 NEK2 NINL NUMA1 ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PKMYT1 PLK1 PLK4 PPP1CB PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PRKACA PRKAR2B RAB8A RBBP4 RPS27A SDCCAG8 SFI1 SKP1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UBA52 UBB UBC WEE1 XPO1 YWHAE YWHAG +Mitotic Metaphase and Anaphase Reactome Pathway AHCTF1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANKLE2 APITD1 AURKB B9D2 BANF1 BIRC5 BUB1 BUB1B BUB3 CASC5 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA5 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 EMD ERCC6L ESPL1 FBXO5 HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 LEMD2 LEMD3 LMNA LMNB1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAD21 RANBP2 RANGAP1 RCC2 RPS27 RPS27A SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC3 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 TMPO UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 VRK1 VRK2 WAPAL XPO1 ZW10 ZWILCH ZWINT +Mitotic Metaphase/Anaphase Transition Reactome Pathway FBXO5 PLK1 +Mitotic Prometaphase Reactome Pathway AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CCNB1 CCNB2 CDC20 CDCA5 CDCA8 CDK1 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CSNK2A1 CSNK2A2 CSNK2B DSN1 ERCC6L HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NCAPD2 NCAPG NCAPH NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAD21 RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC2 SMC3 SMC4 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 WAPAL XPO1 ZW10 ZWILCH ZWINT +Mitotic Prophase Reactome Pathway AAAS ARPP19 BANF1 BLZF1 CCNB1 CCNB2 CDK1 CNEP1R1 CTDNEP1 EMD ENSA GOLGA2 GORASP1 GORASP2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 MAPK1 MAPK3 MASTL MCPH1 NCAPD3 NCAPG2 NCAPH2 NEK6 NEK7 NEK9 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PHF8 PLK1 POM121 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2D PRKCA PRKCB RAB1A RAB1B RAB2A RAE1 RANBP2 RB1 SEH1L SET SETD8 SMC2 SMC4 TMPO TPR USO1 VRK1 VRK2 +Mitotic Spindle Checkpoint Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD1L1 MAD2L1 UBE2C UBE2D1 UBE2E1 +Mitotic Telophase/Cytokinesis Reactome Pathway KIF20A KIF23 MAU2 NIPBL NUDC PDS5A PDS5B PLK1 RAD21 SMC1A SMC3 STAG1 STAG2 WAPAL +Molecules associated with elastic fibres Reactome Pathway BMP10 BMP2 BMP4 BMP7 EFEMP1 EFEMP2 FBLN1 FBLN2 FBLN5 GDF5 ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP2 LTBP3 LTBP4 MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 TGFB1 TGFB2 TGFB3 VTN +Molybdenum cofactor biosynthesis Reactome Pathway GPHN MOCOS MOCS1 MOCS2 MOCS3 NFS1 +Mtb iron assimilation by chelation Reactome Pathway LTF Rv2895c bfr bfrB irtA irtB +Mucopolysaccharidoses Reactome Pathway ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL EXT1 EXT2 FMOD GLB1 GLB1L GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST VCAN +Multifunctional anion exchangers Reactome Pathway SLC26A1 SLC26A2 SLC26A3 SLC26A6 SLC26A7 SLC26A9 +Muscarinic acetylcholine receptors Reactome Pathway CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 +Muscle contraction Reactome Pathway ACTA2 ACTG2 ACTN2 ACTN3 CALD1 CALM1 DES DMD ITGA1 ITGB5 LMOD1 MYBPC1 MYBPC2 MYBPC3 MYH11 MYH3 MYH6 MYH8 MYL1 MYL12B MYL2 MYL3 MYL4 MYL6 MYL6B MYL9 MYLK NEB PXN SORBS1 SORBS3 TCAP TLN1 TMOD1 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TNNT3 TPM1 TPM2 TPM3 TPM4 TTN VCL VIM +MyD88 cascade initiated on plasma membrane Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR10 TLR5 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 fliC +MyD88 dependent cascade initiated on endosome Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX36 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 IRF7 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR7 TLR8 TLR9 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 +MyD88-independent cascade Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 CASP8 CD14 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FOS HMGB1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRF3 IRF7 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TLR3 TLR4 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 +MyD88:Mal cascade initiated on plasma membrane Reactome Pathway AGER APP ATF1 ATF2 BTK CD14 CD36 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TIRAP TLR1 TLR2 TLR4 TLR6 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 porB +Myoclonic epilepsy of Lafora Reactome Pathway AAAS ABCC5 ACAN AGL AGRN ALDOA ALDOB ALDOC AMY1A AMY1B AMY2A AMY2B ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CALM1 CD44 CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL ENO1 ENO2 ENO3 EPM2A EXT1 EXT2 FBP1 FBP2 FMOD G6PC G6PC2 G6PC3 G6PD GALE GALK1 GALT GAPDH GAPDHS GBE1 GCK GCKR GLB1 GLB1L GLCE GNS GOT1 GOT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPI GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 HAS1 HAS2 HAS3 HEXA HEXB HK1 HK2 HK3 HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 IDS IDUA KERA KHK LCT LUM LYVE1 MDH1 MDH2 MGAM NAGLU NCAN NDST1 NDST2 NDST3 NDST4 NHLRC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OGN OMD PAPSS1 PAPSS2 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM POM121 PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKACA PRKACB PRKACG PRPS1 PRPS1L1 PRPS2 PYGB PYGL PYGM RAE1 RANBP2 RPE RPIA RPS27A SDC1 SDC2 SDC3 SDC4 SEH1L SGSH SI SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC26A1 SLC26A2 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC35B2 SLC35B3 SLC35D2 SLC37A4 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A9 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 TALDO1 TKT TPI1 TPR TREH UBA52 UBB UBC UGP2 UST VCAN +Myogenesis Reactome Pathway ABL1 BNIP2 BOC CDC42 CDH15 CDH2 CDH4 CDON CTNNA1 CTNNA2 CTNNB1 MAP2K6 MAPK11 MAPK12 MAPK14 MEF2A MEF2B MEF2C MEF2D MYF5 MYF6 MYOD1 MYOG NEO1 NTN3 SPAG9 TCF12 TCF3 TCF4 +N-Glycan antennae elongation Reactome Pathway B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 MGAT4A MGAT4B MGAT4C MGAT5 ST3GAL4 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +N-glycan antennae elongation in the medial/trans-Golgi Reactome Pathway B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 FUT8 MAN2A1 MAN2A2 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 ST3GAL4 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +N-glycan trimming and elongation in the cis-Golgi Reactome Pathway MAN1A1 MAN1A2 MAN1C1 MANEA MGAT1 +N-glycan trimming in the ER and Calnexin/Calreticulin cycle Reactome Pathway CALR CANX EDEM1 EDEM2 EDEM3 GANAB MAN1B1 MLEC MOGS PDIA3 PRKCSH UGGT1 UGGT2 +NADE modulates death signalling Reactome Pathway CASP2 CASP3 NGF NGFR NGFRAP1 YWHAE +NADPH regeneration Reactome Pathway IDH1 +NCAM signaling for neurite out-growth Reactome Pathway AGRN ARTN CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CDK1 CNTN2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CREB1 FGFR1 FYN GDNF GFRA1 GFRA2 GFRA4 GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NCAN NRAS NRTN PRNP PSPN PTK2 PTPN11 PTPRA RAF1 RPS6KA5 SOS1 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC ST8SIA2 ST8SIA4 TYK2 YWHAB +NCAM1 interactions Reactome Pathway AGRN ARTN CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CNTN2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 GDNF GFRA1 GFRA2 GFRA4 NCAM1 NCAN NRTN PRNP PSPN ST8SIA2 ST8SIA4 +NEP/NS2 Interacts with the Cellular Export Machinery Reactome Pathway AAAS M NP NS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POM121 RAE1 RAN RANBP2 SEH1L TPR XPO1 +NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Reactome Pathway CASP10 CASP8 CHUK DDX58 FADD IFIH1 IKBKB IKBKG MAVS RIPK1 RNF135 TRIM25 +NF-kB is activated and signals survival Reactome Pathway IKBKB IRAK1 NFKB1 NFKBIA NGF NGFR RELA RPS27A SQSTM1 TRAF6 UBA52 UBB UBC +NFG and proNGF binds to p75NTR Reactome Pathway NGF NGFR SORCS3 +NGF processing Reactome Pathway FURIN NGF PCSK5 PCSK6 +NGF signalling via TRKA from the plasma membrane Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADORA2A ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ATF1 BAD BRAF BTC CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CRK CRKL DNAL4 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 EGF EGFR ELK1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIDINS220 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAP1 MAPKAPK2 MAPKAPK3 MDM2 MEF2A MEF2C MIR26A1 MIR26A2 MLST8 MOV10 MTOR NGF NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 NTRK1 NTRK2 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RHOA RICTOR RIT1 RIT2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 SH3GL2 SHC1 SHC2 SHC3 SOS1 SRC STAT3 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 VAV1 YWHAB +NGF-independant TRKA activation Reactome Pathway ADCYAP1 ADCYAP1R1 ADORA2A NTRK1 NTRK2 +NICD traffics to nucleus Reactome Pathway CREBBP KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 +NOD1/2 Signaling Pathway Reactome Pathway BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD IKBKB IKBKG IRAK1 IRAK2 ITCH MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TNFAIP3 TRAF6 UBE2N UBE2V1 +NOSIP mediated eNOS trafficking Reactome Pathway NOS3 NOSIP +NOSTRIN mediated eNOS trafficking Reactome Pathway CAV1 DNM2 NOS3 NOSTRIN WASL +NOTCH1 Intracellular Domain Regulates Transcription Reactome Pathway CCNC CDK8 CREBBP CUL1 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MYC NCOR1 NCOR2 NOTCH1 RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +NOTCH2 Activation and Transmission of Signal to the Nucleus Reactome Pathway ADAM10 APH1A APH1B CNTN1 DLL1 DLL4 JAG1 JAG2 MDK MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH2 PSEN2 PSENEN RPS27A UBA52 UBB UBC +NOTCH2 intracellular domain regulates transcription Reactome Pathway CREB1 EP300 FCER2 GZMB HES1 HES5 MAML1 MAML2 MAML3 MAMLD1 NOTCH2 RBPJ +NRAGE signals death through JNK Reactome Pathway AATF ABR AKAP13 ARHGAP4 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 ECT2 FGD1 FGD2 FGD3 FGD4 ITSN1 KALRN MAGED1 MAPK8 MCF2 MCF2L NET1 NGEF NGF NGFR OBSCN PLEKHG2 PLEKHG5 RAC1 RASGRF2 SOS1 SOS2 TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 +NRIF signals cell death from the nucleus Reactome Pathway APH1A APH1B ITGB3BP MAPK8 NCSTN NGF NGFR PSEN2 PSENEN RPS27A SQSTM1 TRAF6 UBA52 UBB UBC +Na+-dependent glucose transporters Reactome Pathway NAGLT1 SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A9 +Na+/Cl- dependent neurotransmitter transporters Reactome Pathway SLC18A1 SLC18A2 SLC22A1 SLC22A2 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +Nectin/Necl trans heterodimerization Reactome Pathway CADM1 CADM3 PVR PVRL1 PVRL2 PVRL3 PVRL4 +Nef Mediated CD4 Down-regulation Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H CD4 LCK nef +Nef Mediated CD8 Down-regulation Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ATP6V1H CD8B nef +Nef and signal transduction Reactome Pathway CD247 DOCK2 ELMO1 FYN HCK LCK PAK2 RAC1 nef +Nef mediated downregulation of CD28 cell surface expression Reactome Pathway AP2M1 CD28 nef +Nef mediated downregulation of MHC class I complex cell surface expression Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 B2M HLA-A PACS1 nef +Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD28 CD4 CD8B HLA-A LCK PACS1 nef +Negative epigenetic regulation of rRNA expression Reactome Pathway 18S rRNA, 5.8S rRNA, 28S rRNA 28S rRNA ARID4B BAZ2A CCNH CD3EAP CDK7 DNMT1 DNMT3B ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB MBD2 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L RRP8 SAP130 SAP18 SAP30 SAP30BP SAP30L SIN3A SIN3B SIRT1 SMARCA5 SUDS3 SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +Negative regulation of FGFR signaling Reactome Pathway BRAF CBL FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GRB2 KL KLB MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC +Negative regulation of the PI3K/AKT network Reactome Pathway AKT1 AKT2 AKT3 PHLPP1 PHLPP2 PTEN THEM4 TRIB3 +Negative regulators of RIG-I/MDA5 signaling Reactome Pathway ATG12 ATG5 CYLD DDX58 HERC5 IFIH1 IKBKE IRF3 ISG15 ITCH MAVS NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RNF125 RNF135 RPS27A TAX1BP1 TBK1 TNFAIP3 TRAF3 TRIM25 UBA52 UBA7 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 +Nephrin interactions Reactome Pathway ACTN1 ACTN2 ACTN3 ACTN4 CASK CD2AP FYN IQGAP1 KIRREL KIRREL2 KIRREL3 MAGI2 NCK1 NCK2 NPHS1 PIK3CA PIK3CB PIK3R1 PIK3R2 SPTAN1 SPTBN1 WASL +Netrin mediated repulsion signals Reactome Pathway DCC FYN NTN1 PTK2 PTPN11 SRC UNC5A UNC5B UNC5C UNC5D +Netrin-1 signaling Reactome Pathway ABLIM1 ABLIM2 ABLIM3 AGAP2 CDC42 DCC DOCK1 EZR FYN HFE2 MYO10 NCK1 NEO1 NTN1 NTN4 PITPNA PLCG1 PRKCQ PTK2 PTPN11 RAC1 RGMA RGMB ROBO1 SIAH1 SIAH2 SLIT1 SLIT2 SLIT3 SRC TRIO TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 UNC5A UNC5B UNC5C UNC5D WASL +Neurofascin interactions Reactome Pathway ANK1 CNTN1 CNTNAP1 DCX NFASC NRCAM SDCBP +Neuronal System Reactome Pathway ABAT ABCC8 ABCC9 ACHE ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 ALDH2 ALDH5A1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BCHE BRAF BZRAP1 CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CHAT CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG COMT CPLX1 CREB1 DLG1 DLG3 DLG4 DNAJC5 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GAD1 GAD2 GJA10 GJC1 GJD2 GLS GLS2 GLUL GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP1 GRIP2 HCN1 HCN2 HCN3 HCN4 HRAS HSPA8 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 MAOA MAPK1 MDM2 MYO6 NCALD NEFL NSF PANX1 PANX2 PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG RAB3A RAF1 RASGRF1 RASGRF2 RIMS1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC22A1 SLC22A2 SLC32A1 SLC38A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A3 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +Neurophilin interactions with VEGF and VEGFR Reactome Pathway FLT1 KDR NRP1 NRP2 +Neurotoxicity of clostridium toxins Reactome Pathway HA-33 SNAP25 STX1A STX1B SV2A SV2B SV2C SYT1 SYT2 VAMP1 VAMP2 botA botB botD botF botG ha17 ha70 ntnha tetX +Neurotransmitter Clearance In The Synaptic Cleft Reactome Pathway ACHE ALDH2 BCHE COMT MAOA SLC22A1 SLC22A2 SLC6A3 +Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Reactome Pathway ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BRAF CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG CREB1 DLG1 DLG3 DLG4 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP1 GRIP2 HRAS KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 MAPK1 MDM2 MYO6 NCALD NEFL NSF PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +Neurotransmitter Release Cycle Reactome Pathway ABAT ALDH5A1 BZRAP1 CHAT CPLX1 DNAJC5 GAD1 GAD2 GLS GLS2 HSPA8 MAOA PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A6 SLC1A7 SLC22A1 SLC22A2 SLC32A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +Neurotransmitter uptake and Metabolism In Glial Cells Reactome Pathway GLUL SLC1A2 SLC1A3 SLC38A1 +Nicotinamide salvaging Reactome Pathway CYP8B1 NAMPT NAPRT PTGIS PTGS2 +Nicotinate metabolism Reactome Pathway CYP8B1 NADK NADSYN1 NAMPT NAPRT NMNAT1 NMNAT2 NMNAT3 PTGIS PTGS2 QPRT +Nitric oxide stimulates guanylate cyclase Reactome Pathway GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3 ITPR1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 MRVI1 NOS1 NOS2 NOS3 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE9A PRKG1 PRKG2 +NoRC negatively regulates rRNA expression Reactome Pathway 18S rRNA, 5.8S rRNA, 28S rRNA 28S rRNA ARID4B BAZ2A CCNH CD3EAP CDK7 DNMT1 DNMT3B ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB MBD2 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L SAP130 SAP18 SAP30 SAP30BP SAP30L SIN3A SIN3B SMARCA5 SUDS3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +Non-integrin membrane-ECM interactions Reactome Pathway ACTN1 AGRN CASK DAG1 DDR1 DDR2 DMD FGF2 HSPG2 ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 NRXN1 NTN4 PDGFA PDGFB PRKCA SDC1 SDC2 SDC3 SDC4 TGFB1 THBS1 TNC TRAPPC4 TTR VTN +Nonhomologous End-joining (NHEJ) Reactome Pathway LIG4 PRKDC TDP1 XRCC4 XRCC5 XRCC6 +Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Reactome Pathway CASC3 EIF4A3 EIF4G1 ETF1 FAU GSPT2 MAGOH NCBP1 NCBP2 PABPC1 PPP2CA PPP2R1A PPP2R2A RBM8A RNPS1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 UBA52 UPF1 UPF2 UPF3A UPF3B +Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Reactome Pathway EIF4G1 ETF1 FAU GSPT2 NCBP1 NCBP2 PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 UPF1 +Nonsense-Mediated Decay (NMD) Reactome Pathway CASC3 EIF4A3 EIF4G1 ETF1 FAU GSPT2 MAGOH NCBP1 NCBP2 PABPC1 PPP2CA PPP2R1A PPP2R2A RBM8A RNPS1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 UBA52 UPF1 UPF2 UPF3A UPF3B +Norepinephrine Neurotransmitter Release Cycle Reactome Pathway BZRAP1 CPLX1 MAOA PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SLC22A1 SLC22A2 SNAP25 STX1A STXBP1 SYT1 UNC13B VAMP2 +Notch-HLH transcription pathway Reactome Pathway CREBBP KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 +NrCAM interactions Reactome Pathway ANK1 CNTN2 DLG1 DLG3 DLG4 NRCAM NRP2 +Nuclear Envelope Breakdown Reactome Pathway AAAS BANF1 CCNB1 CCNB2 CDK1 CNEP1R1 CTDNEP1 EMD LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 NEK6 NEK7 NEK9 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PLK1 POM121 PRKCA PRKCB RAE1 RANBP2 SEH1L TMPO TPR VRK1 VRK2 +Nuclear Envelope Reassembly Reactome Pathway ANKLE2 BANF1 EMD LEMD2 LEMD3 LMNA LMNB1 PPP2CA PPP2R1A PPP2R2A TMPO VRK1 VRK2 +Nuclear Events (kinase and transcription factor activation) Reactome Pathway ATF1 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MAPKAPK2 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +Nuclear Pore Complex (NPC) Disassembly Reactome Pathway AAAS CCNB1 CCNB2 CDK1 NEK6 NEK7 NEK9 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L TPR +Nuclear Receptor transcription pathway Reactome Pathway AR ESR1 ESR2 ESRRA ESRRB ESRRG HNF4A HNF4G MED1 NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 PGR PPARA PPARD PPARG RARA RARB RARG RORA RORB RORC RXRA RXRB RXRG THRA THRB VDR +Nuclear import of Rev protein Reactome Pathway AAAS KPNB1 NPM1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RAN RANBP2 RCC1 SEH1L TPR +Nuclear signaling by ERBB4 Reactome Pathway ADAM17 APH1A APH1B BTC BTRC CSH1 CSN2 CUL1 CXCL12 ERBB4 EREG ESR1 GFAP GH1 GH2 GHR HBEGF JAK2 NCOR1 NCSTN NRG1 NRG2 NRG3 NRG4 PGR PRL PRLR PSEN2 PSENEN PTPN11 RBX1 S100B SH2B1 SKP1 STAT5A STAT5B TAB2 WWOX YAP1 +Nucleosome assembly Reactome Pathway APITD1 CASC5 CENPA CENPC CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CENPW H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HJURP ITGB3BP MIS18A MIS18BP1 NPM1 OIP5 RBBP4 RBBP7 RSF1 RUVBL1 SMARCA5 STRA13 +Nucleotide Excision Repair Reactome Pathway APEX1 CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 LIG1 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RAD23B RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 TCEA1 XAB2 XPA XPC +Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome Pathway AIM2 APP BCL2 BCL2L1 BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD HSP90AB1 IKBKB IKBKG IRAK1 IRAK2 ITCH MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 MEFV NLRC4 NLRP1 NLRP3 NOD1 NOD2 P2RX7 PANX1 PSTPIP1 PYCARD RIPK2 SUGT1 TAB1 TAB2 TAB3 TNFAIP3 TRAF6 TXN TXNIP UBE2N UBE2V1 fliC fljB hly prgJ +Nucleotide-like (purinergic) receptors Reactome Pathway ADORA1 ADORA2A ADORA2B ADORA3 GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 +O-glycosylation of TSR domain-containing proteins Reactome Pathway ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 B3GALTL CFP POFUT2 SBSPON SEMA5A SEMA5B SPON1 SPON2 SSPO THBS1 THBS2 THSD1 THSD4 THSD7A THSD7B +O-linked glycosylation Reactome Pathway ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 B3GALTL B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT5 B4GALT6 C1GALT1 C1GALT1C1 CFP GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT18 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL5 GALNTL6 GCNT1 GCNT3 GCNT4 GCNT6 GCNT7 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 POFUT2 SBSPON SEMA5A SEMA5B SPON1 SPON2 SSPO ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 THBS1 THBS2 THSD1 THSD4 THSD7A THSD7B WBSCR17 +O-linked glycosylation of mucins Reactome Pathway B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT5 B4GALT6 C1GALT1 C1GALT1C1 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT18 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL5 GALNTL6 GCNT1 GCNT3 GCNT4 GCNT6 GCNT7 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 WBSCR17 +O2/CO2 exchange in erythrocytes Reactome Pathway AQP1 CA1 CA2 CA4 HBA1 HBB RHAG SLC4A1 +Olfactory Signaling Pathway Reactome Pathway GNAL GNB1 GNGT1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AC1P OR10AD1 OR10AG1 OR10C1 OR10D3 OR10D4P OR10G2 OR10G3 OR10G4 OR10G6 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J4 OR10J5 OR10J6P OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR11H1 OR11H2 OR11H4 OR11H6 OR11H7 OR11L1 OR12D2 OR12D3 OR13A1 OR13C2 OR13C3 OR13C4 OR13C5 OR13C8 OR13C9 OR13D1 OR13F1 OR13G1 OR13H1 OR13J1 OR14A16 OR14A2 OR14C36 OR14I1 OR14J1 OR14K1 OR14L1P OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1E3 OR1F1 OR1F12 OR1F2P OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1P1 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AG2 OR2AJ1 OR2AK2 OR2AP1 OR2AT4 OR2B11 OR2B2 OR2B3 OR2B6 OR2B8P OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2H2 OR2I1P OR2J1 OR2J2 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L5 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2T6 OR2T7 OR2T8 OR2V1 OR2V2 OR2W1 OR2W3 OR2W5 OR2W6P OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A4P OR4A5 OR4A8P OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C45 OR4C46 OR4C5 OR4C6 OR4D1 OR4D10 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E1 OR4E2 OR4F15 OR4F17 OR4F21 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K3 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N4 OR4N5 OR4P4 OR4Q2 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F1 OR51F2 OR51G1 OR51G2 OR51H1P OR51I1 OR51I2 OR51J1 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A4 OR52A5 OR52B2 OR52B4 OR52B6 OR52D1 OR52E1 OR52E2 OR52E4 OR52E5 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52L2P OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52P1P OR52R1 OR52W1 OR52Z1 OR56A1 OR56A3 OR56A4 OR56A5 OR56B1 OR56B2P OR56B4 OR5A1 OR5A2 OR5AC1 OR5AC2 OR5AK2 OR5AK3P OR5AL1 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B21 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5G3 OR5H1 OR5H14 OR5H15 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5K3 OR5K4 OR5L1 OR5L2 OR5M1 OR5M10 OR5M11 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6C6 OR6C65 OR6C68 OR6C70 OR6C74 OR6C75 OR6C76 OR6F1 OR6J1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6P1 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A2P OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7E24 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B2 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8G1 OR8G2 OR8G5 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J2 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A1P OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 +Oligomerization of connexins into connexons Reactome Pathway GJA1 GJB1 GJB2 +Oncogene Induced Senescence Reactome Pathway AGO1 AGO3 AGO4 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CDKN2D E2F1 E2F2 E2F3 ERF ETS1 ETS2 ID1 MAPK1 MAPK3 MDM2 MIR24-1 MIR24-2 MOV10 RPS27A SP1 TFDP1 TNRC6A TNRC6B TNRC6C TP53 UBA52 UBB UBC +Opioid Signalling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CDK5 CREB1 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR1 ITPR2 ITPR3 MAPK1 OPRM1 PDE1A PDE1B PDE1C PDE4A PDE4B PDE4C PDE4D PDYN PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 POMC PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +Opsins Reactome Pathway OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 RGR RHO RRH +Orc1 removal from chromatin Reactome Pathway CCNA1 CCNA2 CDC6 CDK2 CDKN1A CDKN1B CDT1 FZR1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RPS27A UBA52 UBB UBC +Orexin and neuropeptides FF and QRFP bind to their respective receptors Reactome Pathway HCRT HCRTR1 HCRTR2 NPFF NPFFR1 NPFFR2 QRFP QRFPR +Organelle biogenesis and maintenance Reactome Pathway ACTR1A AKAP9 ALAS1 ALMS1 ARF4 ARL13B ARL3 ARL6 ASAP1 ATAT1 ATF2 ATP5B AURKAIP1 B9D1 B9D2 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 C2CD3 CALM1 CAMK4 CARM1 CC2D2A CCP110 CCT2 CCT3 CCT4 CCT5 CCT8 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP162 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CEP83 CEP89 CEP97 CETN2 CHCHD1 CHD9 CKAP5 CLASP1 CLUAP1 CNGA2 CNGA4 CNGB1 CNTRL CREB1 CREBBP CSNK1D CSNK1E CYCS CYS1 DAP3 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 ESRRA EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 FBF1 FGFR1OP GABPA GABPB1 GADD45GIP1 GBF1 GFM1 GFM2 HAUS2 HCFC1 HDAC3 HDAC6 HELZ2 HSP90AA1 HSPB11 ICT1 IFT122 IFT140 IFT172 IFT20 IFT22 IFT27 IFT43 IFT46 IFT52 IFT57 IFT74 IFT80 IFT81 IFT88 INPP5E IQCB1 KIF17 KIF24 KIF3A KIF3B KIF3C KIFAP3 LZTFL1 MAPK11 MAPK12 MAPK14 MAPRE1 MARK4 MCHR1 MED1 MEF2C MEF2D MKKS MKS1 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51 MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS6 MRPS7 MRPS9 MRRF MT-RNR1 MT-RNR2 MTERF MTERF1 MTFMT MTIF2 MTIF3 MTRF1L NCOA1 NCOA2 NCOA6 NCOR1 NDE1 NEDD1 NEK2 NINL NPHP1 NPHP3 NPHP4 NR1D1 NRF1 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PDE6D PEO1 PKD1 PKD2 PLK1 PLK4 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPP2R1A PPRC1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKAG1 PRKAG2 PRKAG3 PRKAR2B PTCD3 RAB11A RAB11FIP3 RAB3IP RAB8A RHO RP2 RPGRIP1L RXRA SCLT1 SDCCAG8 SEPT2 SFI1 SIRT3 SMARCD3 SMO SSBP1 SSNA1 SSTR3 TBL1X TBL1XR1 TCP1 TCTE3 TCTEX1D1 TCTEX1D2 TCTN1 TCTN2 TCTN3 TFAM TFB1M TFB2M TGS1 TMEM216 TMEM67 TNPO1 TRAF3IP1 TRIP11 TSFM TTBK2 TTC21B TTC26 TTC30A TTC30B TTC8 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUFM UNC119B WDR19 WDR34 WDR35 WDR60 YWHAE YWHAG +Organic anion transport Reactome Pathway SLC22A11 SLC22A12 SLC22A6 SLC22A7 SLC22A8 +Organic anion transporters Reactome Pathway SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC25A10 SLC5A5 SLC5A8 +Organic cation transport Reactome Pathway SLC22A1 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 +Organic cation/anion/zwitterion transport Reactome Pathway SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 +Orphan transporters Reactome Pathway ABCD4 ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ANXA2 APOB APOD APOF ARHGEF9 ARL2 ARV1 BEST1 BEST2 BEST3 BEST4 CARM1 CERK CETP CHD9 CLCA1 CLCA2 CLCA3P CLCA4 COX11 COX14 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CRABP2 CREBBP CYCS CYP7A1 CYP7B1 FABP6 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ HELZ2 LCN1 LCN12 LCN15 LCN2 LCN9 LRPPRC MED1 MT-CO1 MT-CO2 MT-CO3 NAGLT1 NCOA1 NCOA2 NCOA6 NR1H4 PLAT PLG PPARA RARA RARB RARG RXRA RXRB RXRG S100A10 SCO1 SCO2 SLC10A2 SLC22A17 SLC5A1 SLC5A2 SLC5A4 SLC5A9 SMARCD3 SURF1 TACO1 TBCD TBL1X TBL1XR1 TGS1 TTYH2 TTYH3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 +Other semaphorin interactions Reactome Pathway CD72 ITGA1 ITGB1 PLXNA1 PLXNA2 PLXNA4 PLXNB3 PLXNC1 PLXND1 PTPRC SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A TREM2 TYROBP +Oxidative Stress Induced Senescence Reactome Pathway AGO1 AGO3 AGO4 BMI1 CBX2 CBX4 CBX6 CBX8 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CDKN2D E2F1 E2F2 E2F3 EED EZH2 FOS H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB IFNB1 JUN KDM6B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MDM2 MINK1 MIR24-1 MIR24-2 MOV10 PHC1 PHC2 PHC3 RBBP4 RBBP7 RING1 RNF2 RPS27A SCMH1 SUZ12 TFDP1 TNIK TNRC6A TNRC6B TNRC6C TP53 TXN UBA52 UBB UBC +Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Reactome Pathway EPAS1 HIF1A HIF1AN +Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Reactome Pathway CUL2 EGLN1 EGLN2 EGLN3 EPAS1 HIF1A HIF3A RBX1 RPS27A TCEB1 TCEB2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 VHL +P2Y receptors Reactome Pathway GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 +PAOs oxidise polyamines to amines Reactome Pathway PAOX SMOX +PCP/CE pathway Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARRB2 CLTA CLTB CLTC DAAM1 DVL1 DVL2 DVL3 FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 PARD6A PFN1 PRICKLE1 PRKCA PRKCB PRKCG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC1 RAC2 RAC3 RHOA ROR1 ROR2 RPS27A RYK SCRIB SMURF1 SMURF2 UBA52 UBB UBC VANGL2 WNT1 WNT11 WNT4 WNT5A WNT5B +PD-1 signaling Reactome Pathway CD247 CD274 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK PDCD1 PDCD1LG2 PTPN11 PTPN6 TCRA TCRB TRAC TRBC1 TRBV12-3 +PDE3B signalling Reactome Pathway AKT2 PDE3B +PECAM1 interactions Reactome Pathway FYN INPP5D ITGAV ITGB3 LCK LYN PECAM1 PLCG1 PTPN11 PTPN6 SRC YES1 +PERK regulates gene expression Reactome Pathway ASNS ATF3 ATF4 ATF6 CCL2 CXCL8 DCP2 DDIT3 DIS3 EIF2AK3 EIF2S1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 HSPA5 IGFBP1 IL8 KHSRP NFYA NFYB NFYC PARN +PI Metabolism Reactome Pathway ARF1 ARF3 FIG4 INPP4A INPP4B INPP5D INPP5E INPP5J INPP5K INPPL1 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PITPNB PTEN SACM1L SYNJ1 SYNJ2 TPTE TPTE2 VAC14 +PI and PC transport between ER and Golgi membranes Reactome Pathway PITPNB +PI-3K cascade Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PI3K Cascade Reactome Pathway AKT2 CAB39 CAB39L DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 IRS1 IRS2 KL KLB MLST8 MTOR PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RHEB RPS6 RPS6KB1 RPTOR STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 +PI3K events in ERBB2 signaling Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PI3K events in ERBB4 signaling Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PI3K/AKT Signaling in Cancer Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PI3K/AKT activation Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NGF NR4A1 NRG1 NRG2 NRG3 NRG4 NTRK1 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RHOA RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PIP3 activates AKT signaling Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF IRS1 IRS2 KIT KITLG KL KLB LCK MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +PIWI-interacting RNA (piRNA) biogenesis Reactome Pathway ASZ1 DDX4 FKBP6 HENMT1 HSP90AA1 MAEL MOV10L1 MYBL1 PIWIL1 PIWIL2 PIWIL4 PLD6 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TDRD1 TDRD12 TDRD6 TDRD9 TDRKH +PKA activation Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +PKA activation in glucagon signalling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAS PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +PKA-mediated phosphorylation of CREB Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CREB1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +PKA-mediated phosphorylation of key metabolic factors Reactome Pathway MLXIPL PFKFB1 PRKACA PRKACB PRKACG +PKB-mediated events Reactome Pathway AKT2 CAB39 CAB39L EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 MLST8 MTOR PDE3B PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPS6 RPS6KB1 RPTOR STK11 STRADA STRADB TSC1 TSC2 +PKMTs methylate histone lysines Reactome Pathway ASH2L ATF7IP EHMT1 EHMT2 HIST1H3A HIST1H4A HIST2H3A KMT2A KMT2B KMT2C KMT2D KMT2E NSD1 PRDM8 PRDM9 RBBP5 SETD1A SETD1B SETD2 SETD7 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H1 SUV39H2 WDR5 WHSC1 WHSC1L1 +PLC beta mediated events Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 GNAI1 GNAI2 GNAI3 GNAO1 GNAT1 GNAT2 GNAT3 GNAZ ITPR1 ITPR2 ITPR3 MAPK1 PDE1A PDE1B PDE1C PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +PLC-gamma1 signalling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 ITPR1 ITPR2 ITPR3 NGF NTRK1 PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +PLC-mediated hydrolysis of PIP2 Reactome Pathway PLCG2 +PLCG1 events in ERBB2 signaling Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 EGF EGFR ERBB2 ITPR1 ITPR2 ITPR3 PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome Pathway EPHA1 FGF2 FOXD3 NANOG NR6A1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU5F1 SOX2 STAT3 TDGF1 ZIC3 +POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome Pathway CDX2 DKK1 EOMES GATA6 GSC HHEX NANOG POU5F1 SOX2 TSC22D1 +PP2A-mediated dephosphorylation of key metabolic factors Reactome Pathway MLXIPL PFKFB1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D +PPARA activates gene expression Reactome Pathway ABCA1 ABCB4 ACADM ACOX1 ACSL1 AGT ALAS1 ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARNTL CARM1 CCNC CD36 CDK19 CDK8 CHD9 CLOCK CPT1A CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 EP300 ESRRA FABP1 FADS1 FDFT1 FHL2 G0S2 GLIPR1 GRHL1 HDAC3 HELZ2 HMGCR HMGCS1 HMGCS2 ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NFYA NFYB NFYC NPAS2 NR1D1 NR1H4 NRF1 PEX11A PLIN2 PPARA PPARG PPARGC1A PPARGC1B RGL1 RORA RXRA SLC27A1 SMARCD3 SP1 SREBF1 SREBF2 SULT2A1 TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TGS1 TIAM2 TNFRSF21 TRIB3 TXNRD1 UGT1A9 WWTR1 YAP1 +PRC2 methylates histones and DNA Reactome Pathway AEBP2 DNMT1 DNMT3A DNMT3B EED EZH2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB JARID2 MTF2 PHF1 PHF19 RBBP4 RBBP7 SUZ12 +Packaging Of Telomere Ends Reactome Pathway ACD H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 POT1 TERF1 TERF2 TERF2IP TINF2 +Packaging of Eight RNA Segments Reactome Pathway HA M NA NP NS PA PB1 PB2 +Passive transport by Aquaporins Reactome Pathway AQP1 AQP10 AQP11 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 MIP +Pausing and recovery of HIV elongation Reactome Pathway CCNT1 CCNT2 CDK9 CTDP1 ELL GTF2F1 GTF2F2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +Pausing and recovery of Tat-mediated HIV elongation Reactome Pathway CCNT1 CDK9 CTDP1 ELL GTF2F1 GTF2F2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 tat +Pentose phosphate pathway (hexose monophosphate shunt) Reactome Pathway G6PD PGD PGLS RPE RPIA TALDO1 TKT +Peptide chain elongation Reactome Pathway EEF1A1 EEF2 FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Peptide hormone biosynthesis Reactome Pathway CGA CGB FSHB INHA INHBA INHBB INHBC INHBE LHB PCSK1 POMC TSHB +Peptide hormone metabolism Reactome Pathway ACE ACE2 ACHE AGT ANPEP ATP6AP2 BCHE CDX2 CGA CGB CMA1 CPA3 CPB1 CPB2 CPE CPN1 CTNNB1 CTSD CTSG CTSZ DPP4 ENPEP ERO1L ERO1LB EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 FFAR1 FFAR4 FSHB GATA4 GCG GH1 GHRL GIP GNAT3 GNB3 GNG13 GPR119 GRP GZMH IGF1 INHA INHBA INHBB INHBC INHBE INS ISL1 KIF5A KIF5B KIF5C KLF4 LEP LHB MBOAT4 MME MYO5A PAX6 PCSK1 PCSK2 PLA2G7 POMC RAB27A REN SEC11A SEC11C SLC30A5 SLC30A6 SLC30A7 SLC30A8 SPCS1 SPCS2 SPCS3 STX1A TCF7L2 TSHB VAMP2 +Peptide ligand-binding receptors Reactome Pathway ACKR1 ACKR2 ACKR3 ACKR4 AGT AGTR1 AGTR2 ANXA1 APLN APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FPR1 FPR2 FPR3 GAL GALR1 GALR2 GALR3 GHRL GHSR GPER1 GPR37 GPR37L1 GRP GRPR HCRT HCRTR1 HCRTR2 HEBP1 INSL3 INSL5 KISS1 KISS1R KNG1 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MT-RNR2 NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 OXT OXTR PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PYY QRFP QRFPR RLN2 RLN3 RXFP1 RXFP2 RXFP3 RXFP4 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAC1 TAC3 TACR1 TACR2 TACR3 TRH TRHR UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 +Peroxisomal lipid metabolism Reactome Pathway ABCD1 ACAA1 ACOT8 ACOX1 ACOX2 ACOX3 AGPS AMACR CRAT CROT FAR1 FAR2 GNPAT HACL1 HSD17B4 IDH1 MLYCD PHYH SCP2 SLC25A17 SLC27A2 +Phagosomal maturation (early endosomal stage) Reactome Pathway ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CAMP CYBA CYBB LTF NCF1 NCF2 NCF4 NOS1 NOS2 NOS3 Rv1280c Rv1281c Rv1282c Rv1283c SLC11A1 TCIRG1 +Phase 1 - Functionalization of compounds Reactome Pathway ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX1L FDXR FMO1 FMO2 FMO3 MAOA MAOB NCOA1 NCOA2 NR1H4 PAOX POMC PTGIS PTGS1 RXRA SMOX TBXAS1 +Phase II conjugation Reactome Pathway ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT2 GGT3P GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +Phenylalanine and tyrosine catabolism Reactome Pathway CCBL1 FAH GSTZ1 HGD HPD PAH PCBD1 QDPR TAT +Phosphate bond hydrolysis by NUDT proteins Reactome Pathway NUDT1 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 +Phospholipase C-mediated cascade Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CAMK4 CREB1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 ITPR1 ITPR2 ITPR3 KL KLB PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +Phospholipid metabolism Reactome Pathway ACHE AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 ARF1 ARF3 BCHE CDIPT CDS1 CDS2 CEPT1 CHAT CHKA CHKB CHPT1 CRLS1 DGAT1 DGAT2 EPT1 ETNK1 ETNK2 FIG4 GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L HADHA HADHB INPP4A INPP4B INPP5D INPP5E INPP5J INPP5K INPPL1 LCLAT1 LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 MBOAT1 MBOAT2 MBOAT7 MGLL MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 OCRL PCYT1A PCYT1B PCYT2 PEMT PGS1 PHOSPHO1 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PISD PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLB1 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PNPLA2 PNPLA3 PNPLA8 PTDSS1 PTDSS2 PTEN PTPMT1 SACM1L SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SYNJ1 SYNJ2 TAZ TPTE TPTE2 VAC14 +Phosphorylation of CD3 and TCR zeta chains Reactome Pathway CD247 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK PAG1 PTPRC TCRA TCRB TRAC TRBC1 TRBV12-3 +Phosphorylation of Emi1 Reactome Pathway CCNB1 CDC20 CDK1 FBXO5 FZR1 PLK1 +Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Reactome Pathway CCNE1 CCNE2 CDK2 RB1 +Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Reactome Pathway CCNA1 CCNA2 CDK1 +Phosphorylation of the APC/C Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC23 CDC26 CDC27 CDK1 PLK1 UBE2C UBE2D1 UBE2E1 +Plasmalogen biosynthesis Reactome Pathway AGPS FAR1 FAR2 GNPAT +Platelet Adhesion to exposed collagen Reactome Pathway FCER1G FYN GP1BA GP1BB GP5 GP6 GP9 ITGA1 ITGA10 ITGA2 ITGB1 LYN VWF +Platelet Aggregation (Plug Formation) Reactome Pathway ADRA2A ADRA2B ADRA2C AKT1 APBB1IP BCAR1 CRK CSK F2 FGA FGB FGG FN1 GP1BA GP1BB GP5 GP9 GRB2 ITGA2B ITGB3 MPL PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK THPO TLN1 VWF +Platelet activation, signaling and aggregation Reactome Pathway A2M ABCC4 ACTN1 ACTN2 ACTN4 ADRA2A ADRA2B ADRA2C AKT1 AKT2 AKT3 ALB ALDOA APBB1IP APOA1 APP ARRB1 ARRB2 BCAR1 BRPF3 CALM1 CALU CAP1 CD36 CD63 CD9 CDC42 CFD CFL1 CLU CRK CSF2 CSF2RA CSF2RB CSK DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ EGF F13A1 F2 F2R F2RL2 F2RL3 F5 F8 FCER1G FGA FGB FGG FIGF FLNA FN1 FYN GAB2 GAS6 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GP1BA GP1BB GP5 GP6 GP9 GRB2 HABP4 HGF HRG HSPA5 IGF1 IGF2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA ITGA2B ITGB3 ITPR1 ITPR2 ITPR3 JAK1 JAK2 JAK3 KNG1 LAMP2 LAT LCK LCP2 LEFTY2 LYN MAPK1 MAPK14 MAPK3 MGLL MMRN1 MPL P2RY1 P2RY12 PDGFA PDGFB PDPK1 PECAM1 PF4 PFN1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCG2 PLEK PLG POTEKP PPBP PPIA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ PROS1 PSAP PTK2 PTPN1 RAC1 RAC2 RAF1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RHOA RHOB RHOG SCG3 SELP SERPINA1 SERPINE1 SERPINF2 SERPING1 SHC1 SOD1 SOS1 SPARC SRC SRGN STX4 STXBP3 SYK TBXA2R TF TGFB1 TGFB2 TGFB3 THBS1 THPO TIMP1 TLN1 TMSB4X TRPC3 TRPC6 TRPC7 TTN TUBA4A VAV1 VAV2 VAV3 VCL VEGFA VEGFB VEGFC VWF WDR1 YWHAZ +Platelet calcium homeostasis Reactome Pathway ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 ITPR1 ITPR2 ITPR3 ORAI1 P2RX1 SLC8A1 SLC8A2 SLC8A3 STIM1 TRPC3 TRPC6 TRPC7 +Platelet degranulation Reactome Pathway A2M ABCC4 ACTN1 ACTN2 ACTN4 ALB ALDOA APOA1 APP BRPF3 CALM1 CALU CAP1 CD36 CD63 CD9 CFD CFL1 CLU EGF F13A1 F5 F8 FGA FGB FGG FIGF FLNA FN1 GAS6 HABP4 HGF HRG HSPA5 IGF1 IGF2 ITGA2B ITGB3 KNG1 LAMP2 LEFTY2 MMRN1 PDGFA PDGFB PECAM1 PF4 PFN1 PLEK PLG POTEKP PPBP PPIA PROS1 PSAP SCG3 SELP SERPINA1 SERPINE1 SERPINF2 SERPING1 SOD1 SPARC SRGN TF TGFB1 TGFB2 TGFB3 THBS1 TIMP1 TLN1 TMSB4X TTN TUBA4A VCL VEGFA VEGFB VEGFC VWF WDR1 +Platelet homeostasis Reactome Pathway APOB ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 FGR GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3 ITPR1 ITPR2 ITPR3 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 LRP8 MAPK14 MRVI1 NOS1 NOS2 NOS3 ORAI1 P2RX1 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE9A PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKG1 PRKG2 PTGIR PTPN11 PTPN6 SLC8A1 SLC8A2 SLC8A3 STIM1 TRPC3 TRPC6 TRPC7 +Platelet sensitization by LDL Reactome Pathway APOB FGR LRP8 MAPK14 PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 PTPN6 +Plus-strand DNA synthesis Reactome Pathway PPIA gag gag-pol rev vif vpr vpu +Polo-like kinase mediated events Reactome Pathway CCNB1 CCNB2 CDC25A CDC25C CENPF EP300 FOXM1 LIN37 LIN52 LIN54 LIN9 MYBL2 PKMYT1 PLK1 RBBP4 WEE1 +Polymerase switching Reactome Pathway PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 +Polymerase switching on the C-strand of the telomere Reactome Pathway PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 +Post NMDA receptor activation events Reactome Pathway ACTN2 ADCY1 ADCY3 ADCY8 AKAP9 BRAF CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CREB1 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 PRKACA PRKACB PRKACG RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +Post-Elongation Processing of Intron-Containing pre-mRNA Reactome Pathway ALYREF CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 MAGOH NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 U2AF1 U2AF2 UPF3B +Post-Elongation Processing of Intronless pre-mRNA Reactome Pathway CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 LSM10 LSM11 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +Post-Elongation Processing of the Transcript Reactome Pathway ALYREF CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 LSM10 LSM11 MAGOH NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 U2AF1 U2AF2 UPF3B ZNF473 +Post-chaperonin tubulin folding pathway Reactome Pathway ARL2 TBCA TBCB TBCC TBCD TBCE TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 +Post-transcriptional silencing by small RNAs Reactome Pathway AGO1 AGO2 AGO3 AGO4 TNRC6A TNRC6B TNRC6C +Post-translational modification: synthesis of GPI-anchored proteins Reactome Pathway DPM1 DPM2 DPM3 GPAA1 PGAP1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLAUR +Post-translational protein modification Reactome Pathway ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK B3GALTL B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 C1GALT1 C1GALT1C1 CALR CANX CFP CMAS CTSA DAD1 DDOST DHDDS DHPS DNAJC24 DOHH DOLK DOLPP1 DPAGT1 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 EEF2 EIF5A EIF5A2 F10 F2 F7 F9 FURIN FUT8 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT18 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL5 GALNTL6 GANAB GAS6 GCNT1 GCNT3 GCNT4 GCNT6 GCNT7 GFPT1 GFPT2 GGCX GLB1 GMPPA GMPPB GNE GNPNAT1 GPAA1 LMAN1 MAGT1 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPDU1 MPI MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PDIA3 PGAP1 PGM3 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLAUR PMM1 PMM2 POFUT2 PREB PRKCSH PROC PROS1 PROZ RFT1 RPN1 RPN2 SAE1 SAR1B SBSPON SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEMA5A SEMA5B SENP1 SENP2 SENP5 SLC17A5 SLC35A1 SPON1 SPON2 SRD5A3 SSPO ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 STS STT3A SUMF1 SUMF2 SUMO1 SUMO2 SUMO3 THBS1 THBS2 THSD1 THSD4 THSD7A THSD7B TUSC3 UAP1 UBA2 UBE2I UGGT1 UGGT2 VKORC1 WBSCR17 +Postsynaptic nicotinic acetylcholine receptors Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG +Potassium Channels Reactome Pathway ABCC8 ABCC9 GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HCN1 HCN2 HCN3 HCN4 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 +Potassium transport channels Reactome Pathway KCNJ1 KCNJ10 KCNJ16 +Pre-NOTCH Expression and Processing Reactome Pathway AGO1 AGO2 AGO3 AGO4 ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCND1 CREBBP E2F1 E2F3 EP300 FURIN JUN KAT2A KAT2B LFNG MAML1 MAML2 MAML3 MAMLD1 MFNG MIR150 MIR181C MIR200B MIR200C MIR206 MIR302A MIR34A MIR34B MIR34C MIR449A MIR449B MIR449C MOV10 NOTCH1 NOTCH2 NOTCH3 NOTCH4 POFUT1 POGLUT1 RAB6A RBPJ RFNG SEL1L SNW1 ST3GAL3 ST3GAL4 ST3GAL6 TFDP1 TFDP2 TMED2 TNRC6A TNRC6B TNRC6C TP53 +Pre-NOTCH Processing in Golgi Reactome Pathway ATP2A1 ATP2A2 ATP2A3 B4GALT1 FURIN LFNG MFNG NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAB6A RFNG SEL1L ST3GAL3 ST3GAL4 ST3GAL6 TMED2 +Pre-NOTCH Processing in the Endoplasmic Reticulum Reactome Pathway NOTCH1 NOTCH2 NOTCH3 NOTCH4 POFUT1 POGLUT1 +Pre-NOTCH Transcription and Translation Reactome Pathway AGO1 AGO2 AGO3 AGO4 CCND1 CREBBP E2F1 E2F3 EP300 JUN KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIR150 MIR181C MIR200B MIR200C MIR206 MIR302A MIR34A MIR34B MIR34C MIR449A MIR449B MIR449C MOV10 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 TFDP1 TFDP2 TNRC6A TNRC6B TNRC6C TP53 +Prefoldin mediated transfer of substrate to CCT/TriC Reactome Pathway ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 +Pregnenolone biosynthesis Reactome Pathway AKR1B1 CYP11A1 FDX1 FDX1L FDXR STAR STARD4 STARD5 STARD6 +Presynaptic function of Kainate receptors Reactome Pathway GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIK3 PLCB1 PLCB2 PLCB3 +Presynaptic nicotinic acetylcholine receptors Reactome Pathway CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG +Presynaptic phase of homologous DNA pairing and strand exchange Reactome Pathway BRCA2 RAD51 RAD52 RPA1 RPA2 RPA3 +Processing and activation of SUMO Reactome Pathway SAE1 SENP1 SENP2 SENP5 SUMO1 SUMO2 SUMO3 UBA2 UBE2I +Processing of Capped Intron-Containing Pre-mRNA Reactome Pathway AAAS ALYREF BCAS2 CCAR1 CD2BP2 CDC40 CDC5L CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTNNBL1 CWC15 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 EIF4E FUS GTF2F1 GTF2F2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 HSPA8 LSM2 MAGOH METTL3 NCBP1 NCBP2 NHP2L1 NUDT21 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A PLRG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PRPF19 PRPF4 PRPF6 PRPF8 PTBP1 RAE1 RANBP2 RBM5 RBM8A RBMX RNPS1 SEH1L SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SLBP SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 TPR TXNL4A U2AF1 U2AF2 UPF3B YBX1 +Processing of Capped Intronless Pre-mRNA Reactome Pathway CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 LSM10 LSM11 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +Processing of DNA double-strand break ends Reactome Pathway RPA1 RPA2 RPA3 +Processing of DNA ends prior to end rejoining Reactome Pathway PRKDC TDP1 XRCC5 XRCC6 +Processing of Intronless Pre-mRNAs Reactome Pathway CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 +Processing-defective Hh variants abrogate ligand secretion Reactome Pathway ADAM17 DERL2 DHH DISP2 ERLEC1 GPC5 HHAT IHH NOTUM OS9 P4HB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SCUBE2 SEL1L SHH SYVN1 UBA52 UBB UBC VCP +Processive synthesis on the C-strand of the telomere Reactome Pathway APEX1 DNA2 FEN1 LIG1 PCNA POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +Processive synthesis on the lagging strand Reactome Pathway APEX1 DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RPA1 RPA2 RPA3 +Programmed Cell Death Reactome Pathway ACIN1 ADAM17 ADD1 AKT1 AKT2 AKT3 APAF1 APC APPL1 ARHGAP10 BAD BAK1 BAX BBC3 BCAP31 BCL2 BCL2L1 BCL2L11 BID BIRC2 BMF BMX CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CDH1 CFLAR CLSPN CTNNB1 CYCS DAPK1 DAPK2 DAPK3 DBNL DCC DFFA DFFB DIABLO DNM1L DSG1 DSG2 DSG3 DSP DYNLL1 DYNLL2 E2F1 FADD FAS FASLG FNTA GAS2 GSN GZMB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 LMNA LMNB1 MAGED1 MAPK8 MAPT MC159L MST4 NMT1 OCLN ORF71 PAK2 PKP1 PLEC PMAIP1 PPP3CC PPP3R1 PRKCD PRKCQ PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTK2 RIPK1 ROCK1 RPS27A SATB1 SFN SPTAN1 STK24 TFDP1 TJP1 TJP2 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFSF10 TP53 TRADD TRAF2 UBA52 UBB UBC UNC5A UNC5B VIM XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 Reactome Pathway MAN1A1 MAN1A2 MAN1C1 +Prolactin receptor signaling Reactome Pathway BTRC CSH1 CUL1 GH1 GH2 GHR JAK2 PRL PRLR PTPN11 RBX1 SH2B1 SKP1 STAT5A STAT5B +Proline catabolism Reactome Pathway ALDH4A1 PRODH +Prolonged ERK activation events Reactome Pathway BRAF CDK1 CRK CRKL FRS2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 PLCG1 PTPN11 RAF1 RAP1A RAPGEF1 TYK2 YWHAB +Propionyl-CoA catabolism Reactome Pathway MCEE MMAA MUT PCCA PCCB +Prostacyclin signalling through prostacyclin receptor Reactome Pathway GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PTGIR +Prostanoid ligand receptors Reactome Pathway PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R +Protein folding Reactome Pathway ACTB AP3M1 ARFGEF2 ARL2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 KIF13A KIFC3 LONP2 NOP56 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 SKIV2L SPHK1 TBCA TBCB TBCC TBCD TBCE TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 USP11 VBP1 XRN2 +Proton-coupled monocarboxylate transport Reactome Pathway SLC16A1 SLC16A3 SLC16A7 SLC16A8 +Proton-coupled neutral amino acid transporters Reactome Pathway SLC36A1 SLC36A2 +Proton/oligonucleotide cotransporters Reactome Pathway SLC15A1 SLC15A2 SLC15A3 SLC15A4 +Purine catabolism Reactome Pathway CAT GDA GPX1 NT5C NT5C1A NT5C1B NT5C2 NT5E PNP XDH +Purine metabolism Reactome Pathway ADA ADAL ADK ADSL ADSS ADSSL1 AMPD1 AMPD2 AMPD3 APRT ATIC CAT DCK DGUOK GART GDA GMPR GMPR2 GMPS GPX1 HPRT1 IMPDH1 IMPDH2 NT5C NT5C1A NT5C1B NT5C2 NT5E PAICS PFAS PNP PPAT XDH +Purine ribonucleoside monophosphate biosynthesis Reactome Pathway ADSL ADSS ADSSL1 ATIC GART GMPS IMPDH1 IMPDH2 PAICS PFAS PPAT +Purine salvage Reactome Pathway ADA ADAL ADK AMPD1 AMPD2 AMPD3 APRT DCK DGUOK GMPR GMPR2 HPRT1 PNP +Pyrimidine biosynthesis Reactome Pathway CAD DCTD DHODH DUT TYMS UMPS +Pyrimidine catabolism Reactome Pathway AGXT2 DPYD DPYS NT5C NT5C1A NT5C3A NT5E NT5M TYMP UPB1 UPP1 UPP2 +Pyrimidine metabolism Reactome Pathway AGXT2 CAD CDA DCK DCTD DHODH DPYD DPYS DUT NT5C NT5C1A NT5C3A NT5E NT5M TK1 TK2 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 +Pyrimidine salvage reactions Reactome Pathway CDA DCK TK1 TK2 TYMP UCK1 UCK2 UPP1 UPP2 +Pyrophosphate hydrolysis Reactome Pathway PPA1 PPA2 +Pyruvate metabolism Reactome Pathway BSG DLAT DLD LDHA LDHB MPC1 MPC2 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PPARD RXRA SLC16A1 SLC16A3 SLC16A8 +Pyruvate metabolism and Citric Acid (TCA) cycle Reactome Pathway ACO2 ADHFE1 BSG CS D2HGDH DLAT DLD DLST FH IDH2 IDH3A IDH3B IDH3G L2HGDH LDHA LDHB MDH2 MPC1 MPC2 NNT OGDH PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PPARD RXRA SDHA SDHB SDHC SDHD SLC16A1 SLC16A3 SLC16A8 SUCLA2 SUCLG1 SUCLG2 +RA biosynthesis pathway Reactome Pathway ADH1A ADH1C ADH4 AKR1C3 ALDH1A1 ALDH1A2 ALDH1A3 CRABP1 CYP26A1 CYP26B1 CYP26C1 DHRS3 DHRS4 DHRS9 RDH10 RDH11 RDH13 RDH14 RDH16 RDH5 SDR16C5 +RAF activation Reactome Pathway HRAS KRAS NRAS RAF1 YWHAB +RAF phosphorylates MEK Reactome Pathway HRAS KRAS MAP2K1 MAP2K2 NRAS RAF1 YWHAB +RAF/MAP kinase cascade Reactome Pathway CDK1 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 TYK2 YWHAB +REV-ERBA represses gene expression Reactome Pathway ARNTL CARM1 CHD9 CLOCK CREBBP ELOVL3 EP300 HDAC3 HELZ2 MED1 NCOA1 NCOA2 NCOA6 NCOR1 NPAS2 NR1D1 PPARA PPARGC1A RORA RXRA SMARCD3 TBL1X TBL1XR1 TGS1 +RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Reactome Pathway AGER APP ATG12 ATG5 CASP10 CASP8 CHUK CREBBP CYLD DAK DDX58 DHX36 DHX58 DHX9 EP300 FADD HERC5 HMGB1 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IRF1 IRF2 IRF3 IRF7 ISG15 ITCH MAP3K1 MAVS MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RELA RIPK1 RNF125 RNF135 RPS27A S100A12 S100B SAA1 SIKE1 TANK TAX1BP1 TBK1 TNFAIP3 TRAF2 TRAF3 TRAF6 TRIM25 UBA52 UBA7 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 +RIP-mediated NFkB activation via ZBP1 Reactome Pathway AGER APP CHUK DHX9 HMGB1 IKBKB IKBKG MYD88 NFKB1 NFKB2 NFKBIA NFKBIB RELA RIPK1 RIPK3 S100A12 S100B SAA1 TICAM1 TLR3 ZBP1 +RMTs methylate histone arginines Reactome Pathway ACTL6A ACTL6B ARID1A ARID1B ARID2 CARM1 CCND1 CDK4 COPRS DNMT3A H2AFB1 H2AFX H2AFZ HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AG HIST1H2AH HIST1H2AJ HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AB HIST2H2AC HIST2H3A HIST3H2A JAK2 PBRM1 PRMT1 PRMT5 PRMT6 PRMT7 RBBP7 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 WDR5 WDR77 +RNA Pol II CTD phosphorylation and interaction with CE Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT RNMT SUPT5H +RNA Polymerase I Chain Elongation Reactome Pathway CBX3 CCNH CD3EAP CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L TAF1A TAF1B TAF1C TAF1D TBP TWISTNB UBTF ZNRD1 +RNA Polymerase I Promoter Clearance Reactome Pathway 28S rRNA CCNH CD3EAP CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB KAT2A KAT2B MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +RNA Polymerase I Promoter Escape Reactome Pathway CCNH CD3EAP CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L RRN3 TAF1A TAF1B TAF1C TAF1D TBP TWISTNB UBTF ZNRD1 +RNA Polymerase I Promoter Opening Reactome Pathway H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB MAPK3 MBD2 UBTF +RNA Polymerase I Transcription Reactome Pathway 28S rRNA CBX3 CCNH CD3EAP CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB KAT2A KAT2B MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L PTRF RBBP4 RBBP7 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +RNA Polymerase I Transcription Initiation Reactome Pathway 28S rRNA CCNH CD3EAP CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 HDAC1 HDAC2 KAT2A KAT2B MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +RNA Polymerase I Transcription Termination Reactome Pathway 28S rRNA CCNH CD3EAP CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L PTRF TAF1A TAF1B TAF1C TAF1D TBP TTF1 TWISTNB UBTF ZNRD1 +RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Reactome Pathway 28S rRNA BDP1 BRF1 BRF2 CBX3 CCNH CD3EAP CDK7 CHD3 CHD4 CRCP EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB KAT2A KAT2B MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 MTERF1 NFIA NFIB NFIC NFIX POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRMT POU2F1 PTRF RBBP4 RBBP7 RRN3 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TAF1A TAF1B TAF1C TAF1D TBP TFAM TFB2M TTF1 TWISTNB UBTF ZNF143 ZNRD1 +RNA Polymerase II HIV Promoter Escape Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +RNA Polymerase II Pre-transcription Events Reactome Pathway CCNH CCNT1 CCNT2 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 +RNA Polymerase II Promoter Escape Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +RNA Polymerase II Transcription Reactome Pathway ALYREF CCNH CCNT1 CCNT2 CDC40 CDK7 CDK9 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTDP1 DHX38 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 LSM10 LSM11 MAGOH MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE NUDT21 PABPN1 PAPOLA PCF11 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBM8A RNGTT RNMT RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 U2AF1 U2AF2 UPF3B ZNF473 +RNA Polymerase II Transcription Elongation Reactome Pathway CCNH CCNT1 CCNT2 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 +RNA Polymerase II Transcription Initiation Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +RNA Polymerase II Transcription Initiation And Promoter Clearance Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP +RNA Polymerase II Transcription Termination Reactome Pathway ALYREF CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 LSM10 LSM11 MAGOH NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 U2AF1 U2AF2 UPF3B ZNF473 +RNA Polymerase III Abortive And Retractive Initiation Reactome Pathway BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TBP ZNF143 +RNA Polymerase III Chain Elongation Reactome Pathway CRCP POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K +RNA Polymerase III Transcription Reactome Pathway BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TBP ZNF143 +RNA Polymerase III Transcription Initiation Reactome Pathway BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 TBP ZNF143 +RNA Polymerase III Transcription Initiation From Type 1 Promoter Reactome Pathway BDP1 BRF1 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP +RNA Polymerase III Transcription Initiation From Type 2 Promoter Reactome Pathway BDP1 BRF1 CRCP GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP +RNA Polymerase III Transcription Initiation From Type 3 Promoter Reactome Pathway BDP1 BRF2 CRCP POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 TBP ZNF143 +RNA Polymerase III Transcription Termination Reactome Pathway CRCP NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K SSB +RNF mutants show enhanced WNT signaling and proliferation Reactome Pathway AKT1 AKT2 AMER1 APC ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CAV1 CBY1 CCDC88C CDC73 CHD8 CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTNNB1 CTNNBIP1 CUL3 CXXC4 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD4 FZD5 FZD6 FZD8 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MEN1 MYC PIP5K1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RBBP5 RBX1 RNF146 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SFRP1 SFRP2 SMARCA4 SMURF2 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TNKS TNKS2 TRRAP UBA52 UBB UBC USP34 USP8 WIF1 WNT1 WNT3 WNT3A WNT4 WNT5A WNT8A WNT8B WNT9A XIAP XPO1 YWHAZ ZNRF3 +RORA activates circadian gene expression Reactome Pathway ARNTL CARM1 CHD9 CLOCK CPT1A CREBBP EP300 HDAC3 HELZ2 MED1 NCOA1 NCOA2 NCOA6 NCOR1 NPAS2 NR1D1 PPARA PPARGC1A RORA RXRA SMARCD3 SREBF1 TBL1X TBL1XR1 TGS1 +RSK activation Reactome Pathway MAPK1 PDPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 +Rap1 signalling Reactome Pathway PRKACA PRKACB PRKACG PRKG1 RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SIPA1 YWHAB YWHAZ +Ras activation uopn Ca2+ infux through NMDA receptor Reactome Pathway ACTN2 AKAP9 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS NEFL RASGRF1 RASGRF2 +Reactions specific to the complex N-glycan synthesis pathway Reactome Pathway FUT8 MAN2A1 MAN2A2 MGAT2 +Reactions specific to the hybrid N-glycan synthesis pathway Reactome Pathway MGAT3 +Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor Reactome Pathway ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RPS27A UBA52 UBB UBC +Recognition and association of DNA glycosylase with site containing an affected purine Reactome Pathway MPG MUTYH OGG1 +Recognition and association of DNA glycosylase with site containing an affected pyrimidine Reactome Pathway CCNO MBD4 NTHL1 SMUG1 TDG UNG +Recruitment of NuMA to mitotic centrosomes Reactome Pathway CCNB1 CDK1 NEDD1 NUMA1 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 +Recruitment of mitotic centrosome proteins and complexes Reactome Pathway ACTR1A AKAP9 ALMS1 CCNB1 CCP110 CDK1 CDK11A CDK11B CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL NUMA1 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 YWHAE YWHAG +Recruitment of repair and signaling proteins to double-strand breaks Reactome Pathway ATM BRCA1 H2AFX MDC1 MRE11A NBN RAD50 TP53BP1 +Recycling of bile acids and salts Reactome Pathway ABCB11 ABCC3 ALB BAAT FABP6 NCOA1 NCOA2 NR1H4 RXRA SLC10A1 SLC10A2 SLC27A5 SLCO1A2 SLCO1B1 SLCO1B3 +Recycling of eIF2:GDP Reactome Pathway EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 +Recycling pathway of L1 Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA DNM1 DNM2 DNM3 DPYSL2 EZR KIAA1598 KIF4A KIF4B L1CAM MAPK1 MSN NUMB RDX RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SH3GL2 SRC +Reduction of cytosolic Ca++ levels Reactome Pathway ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 SLC8A1 SLC8A2 SLC8A3 +Regulated proteolysis of p75NTR Reactome Pathway ADAM17 APH1A APH1B NCSTN NFKB1 NGFR PSEN2 PSENEN RELA TRAF6 +Regulation by TREX1 Reactome Pathway TREX1 +Regulation by c-FLIP Reactome Pathway CASP8 CFLAR FADD FAS FASLG RIPK1 TNFRSF10A TNFRSF10B TNFSF10 TRADD TRAF2 +Regulation of AMPK activity via LKB1 Reactome Pathway CAB39 CAB39L PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 STRADA STRADB +Regulation of APC/C activators between G1/S and early anaphase Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SKP1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Regulation of Apoptosis Reactome Pathway ARHGAP10 PAK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Regulation of Commissural axon pathfinding by Slit and Robo Reactome Pathway ROBO1 ROBO2 ROBO3 SLIT2 +Regulation of Complement cascade Reactome Pathway C2 C3 C4A C4B C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CFB CFH CFHR3 CFI CR1 PROS1 VTN +Regulation of DNA replication Reactome Pathway CCNA1 CCNA2 CDC6 CDK2 CDKN1A CDKN1B CDT1 E2F1 E2F2 E2F3 FZR1 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RPS27A UBA52 UBB UBC +Regulation of Glucokinase by Glucokinase Regulatory Protein Reactome Pathway AAAS GCK GCKR NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L TPR +Regulation of HSF1-mediated heat shock response Reactome Pathway ATM ATR CCAR2 COL4A6 CRYBA4 DEDD2 DNAJB1 DNAJB6 FKBP4 GML GSK3B HSBP1 HSBP2 HSF1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPH1 MAPK1 MAPK3 MAPKAPK2 MRPL18 RLN1 RPA1 RPA2 RPA3 RPS19BP1 SERPINH1 SIRT1 TNFRSF21 UBB YWHAE +Regulation of Hypoxia-inducible Factor (HIF) by oxygen Reactome Pathway ARNT CA9 CREBBP CUL2 EGLN1 EGLN2 EGLN3 EP300 EPAS1 EPO HIF1A HIF1AN HIF3A RBX1 RPS27A TCEB1 TCEB2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 VEGFA VHL +Regulation of IFNA signaling Reactome Pathway IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 JAK1 PTPN1 PTPN11 PTPN6 SOCS1 SOCS3 STAT1 STAT2 TYK2 USP18 +Regulation of IFNG signaling Reactome Pathway IFNG IFNGR1 IFNGR2 JAK1 JAK2 PIAS1 PTPN1 PTPN11 PTPN2 PTPN6 SOCS1 SOCS3 STAT1 SUMO1 +Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Reactome Pathway CTSG F2 GZMH IGF1 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 KLK1 KLK13 KLK2 KLK3 MMP1 MMP2 PAPPA PAPPA2 PLG +Regulation of KIT signaling Reactome Pathway CBL FYN GRB2 KIT KITLG LCK LYN PRKCA PTPN6 SH2B2 SH2B3 SOCS1 SOCS6 SOS1 SRC YES1 +Regulation of PAK-2p34 activity by PS-GAP/RHG10 Reactome Pathway ARHGAP10 PAK2 +Regulation of PLK1 Activity at G2/M Transition Reactome Pathway ACTR1A AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNB1 CCNB2 CCP110 CDK1 CDK5RAP2 CENPJ CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FBXW11 FGFR1OP HAUS2 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP1CB PPP1R12A PPP1R12B PPP2R1A PRKACA PRKAR2B RAB8A RPS27A SDCCAG8 SFI1 SKP1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 UBA52 UBB UBC YWHAE YWHAG +Regulation of Rheb GTPase activity by AMPK Reactome Pathway PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB TSC1 TSC2 +Regulation of actin dynamics for phagocytic cup formation Reactome Pathway ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CFL1 CRK CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2A FCGR3A GRB2 HSP90AA1 HSP90AB1 IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 LIMK1 MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKIPSD PAK1 PTK2 RAC1 SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 +Regulation of activated PAK-2p34 by proteasome mediated degradation Reactome Pathway PAK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Regulation of beta-cell development Reactome Pathway AKT1 AKT2 AKT3 FGF10 FOXA2 FOXA3 FOXO1 GCK HES1 HNF1A HNF1B HNF4A HNF4G IAPP INS INSM1 MAFA NEUROD1 NEUROG3 NKX2-2 NKX6-1 NOTCH1 NR5A2 ONECUT1 ONECUT3 PAX4 PAX6 PDX1 PKLR PTF1A RBPJ SLC2A2 +Regulation of cholesterol biosynthesis by SREBP (SREBF) Reactome Pathway ACACA ACACB CARM1 CHD9 CREBBP CYP51A1 DHCR7 ELOVL6 FASN FDFT1 FDPS GGPS1 GPAM HELZ2 HMGCR HMGCS1 IDI1 INSIG1 INSIG2 KPNB1 LSS MBTPS1 MBTPS2 MED1 MVD MVK NCOA1 NCOA2 NCOA6 NFYA NFYB NFYC PMVK PPARA RAN RXRA SAR1B SC5D SC5DL SCAP SEC23A SEC24A SEC24B SEC24C SEC24D SMARCD3 SP1 SQLE SREBF1 SREBF2 TBL1X TBL1XR1 TGS1 TM7SF2 +Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Reactome Pathway ACTN1 ARHGEF6 LIMS1 PARVA PARVB PXN RSU1 TESK1 +Regulation of gap junction activity Reactome Pathway GJA1 SRC TJP1 +Regulation of gene expression by Hypoxia-inducible Factor Reactome Pathway ARNT CA9 CREBBP EP300 EPAS1 EPO HIF1A HIF3A VEGFA +Regulation of gene expression in beta cells Reactome Pathway AKT1 AKT2 AKT3 FOXA2 FOXA3 FOXO1 GCK HNF1A HNF4A HNF4G IAPP INS MAFA NEUROD1 NKX2-2 NKX6-1 PAX6 PDX1 PKLR SLC2A2 +Regulation of gene expression in early pancreatic precursor cells Reactome Pathway FGF10 HNF1B NKX6-1 NR5A2 ONECUT1 ONECUT3 PDX1 PTF1A +Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Reactome Pathway INSM1 NEUROD1 NEUROG3 NKX2-2 PAX4 +Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Reactome Pathway HES1 HNF1B NEUROG3 NOTCH1 ONECUT1 ONECUT3 RBPJ +Regulation of innate immune responses to cytosolic DNA Reactome Pathway DDX41 DTX4 IRF3 NLRP4 RPS27A TBK1 TMEM173 TREX1 TRIM21 TRIM32 TRIM56 UBA52 UBB UBC ZBP1 +Regulation of insulin secretion Reactome Pathway ABCC8 ADCY5 ADCY6 ADCY8 ADRA2A ADRA2C AKAP5 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CHRM3 FFAR1 GCG GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 INS IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 MARCKS PLCB1 PLCB2 PLCB3 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAPGEF3 RAPGEF4 SLC25A4 SLC25A5 SLC25A6 SLC2A1 SLC2A2 SNAP25 STX1A STXBP1 SYT5 VAMP2 +Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Reactome Pathway ABCA1 ABCB4 ACADM ACOX1 ACSL1 AGT ALAS1 ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARNTL CARM1 CCNC CD36 CDK19 CDK8 CHD9 CLOCK CPT1A CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 EP300 ESRRA FABP1 FADS1 FDFT1 FHL2 G0S2 GLIPR1 GRHL1 HDAC3 HELZ2 HMGCR HMGCS1 HMGCS2 ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NFYA NFYB NFYC NPAS2 NR1D1 NR1H4 NRF1 PEX11A PLIN2 PPARA PPARG PPARGC1A PPARGC1B RGL1 RORA RXRA SIN3A SIN3B SLC27A1 SMARCD3 SP1 SREBF1 SREBF2 SULT2A1 TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TGS1 TIAM2 TNFRSF21 TRIB3 TXNRD1 UGT1A9 WWTR1 YAP1 +Regulation of mRNA stability by proteins that bind AU-rich elements Reactome Pathway AKT1 ANP32A DCP1A DCP2 DIS3 EIF4G1 ELAVL1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HNRNPD HSPA1A HSPA8 HSPB1 KHSRP MAPK11 MAPK14 MAPKAPK2 NUP214 PABPC1 PARN PRKCA PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SET TNFSF13 TNPO1 UBA52 UBB UBC XPO1 XRN1 YWHAB YWHAZ ZFP36 ZFP36L1 +Regulation of mitotic cell cycle Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RPS27A SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Regulation of ornithine decarboxylase (ODC) Reactome Pathway AZIN1 NQO1 OAZ1 OAZ2 OAZ3 ODC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 +Regulation of pyruvate dehydrogenase (PDH) complex Reactome Pathway DLAT DLD PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PPARD RXRA +Regulation of signaling by CBL Reactome Pathway BLNK CBL CRK CRKL FYN GRB2 HCK LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAPGEF1 SYK VAV1 YES1 +Regulation of signaling by NODAL Reactome Pathway ACVR1B ACVR1C ACVR2A ACVR2B CER1 CFC1 LEFTY1 LEFTY2 NODAL TDGF1 +Regulation of the Fanconi anemia pathway Reactome Pathway ATM ATR FANCD2 FANCI RPS27A UBA52 UBB UBC USP1 ZBTB32 +Regulation of thyroid hormone activity Reactome Pathway DIO1 DIO2 DIO3 +Regulatory RNA pathways Reactome Pathway AAAS AGO1 AGO2 AGO3 AGO4 ASZ1 DDX4 DGCR8 DICER1 DROSHA FKBP6 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HENMT1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HSP90AA1 IPO8 MAEL MOV10L1 MYBL1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PIWIL1 PIWIL2 PIWIL4 PLD6 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PRKRA RAE1 RAN RANBP2 SEH1L TARBP2 TDRD1 TDRD12 TDRD6 TDRD9 TDRKH TNRC6A TNRC6B TNRC6C TPR TSN TSNAX XPO5 +Relaxin receptors Reactome Pathway INSL3 INSL5 RLN2 RLN3 RXFP1 RXFP2 RXFP3 RXFP4 +Release Reactome Pathway HA M NA NP NS PA PB1 PB2 +Release of Hh-Np from the secreting cell Reactome Pathway ADAM17 DHH DISP2 GPC5 IHH NOTUM SCUBE2 SHH +Release of apoptotic factors from the mitochondria Reactome Pathway CYCS DIABLO +Release of eIF4E Reactome Pathway EIF4E EIF4EBP1 MLST8 MTOR RHEB RPTOR +Removal of DNA patch containing abasic residue Reactome Pathway APEX1 CCNO FEN1 LIG1 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG UNG +Removal of aminoterminal propeptides from gamma-carboxylated proteins Reactome Pathway F10 F2 F7 F9 FURIN GAS6 PROC PROS1 PROZ +Removal of licensing factors from origins Reactome Pathway CCNA1 CCNA2 CDC6 CDK2 CDKN1A CDKN1B CDT1 FZR1 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RPS27A UBA52 UBB UBC +Removal of the Flap Intermediate Reactome Pathway DNA2 FEN1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RPA1 RPA2 RPA3 +Removal of the Flap Intermediate from the C-strand Reactome Pathway DNA2 FEN1 PCNA POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +Repair synthesis for gap-filling by DNA polymerase in TC-NER Reactome Pathway PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Repair synthesis of patch ~27-30 bases long by DNA polymerase Reactome Pathway PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Reproduction Reactome Pathway ACR ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG CD9 HVCN1 IZUMO1 IZUMO2 IZUMO3 IZUMO4 KCNU1 OVGP1 SPAM1 ZP1 ZP2 ZP3 ZP4 +Resolution of AP sites via the multiple-nucleotide patch replacement pathway Reactome Pathway APEX1 CCNO FEN1 LIG1 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG UNG +Resolution of AP sites via the single-nucleotide replacement pathway Reactome Pathway APEX1 CCNO LIG3 MBD4 MPG MUTYH NTHL1 OGG1 POLB SMUG1 TDG UNG XRCC1 +Resolution of Abasic Sites (AP sites) Reactome Pathway APEX1 CCNO FEN1 LIG1 LIG3 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG UNG XRCC1 +Resolution of D-loop structures Reactome Pathway APEX1 LIG1 +Resolution of D-loop structures through Holliday junction intermediates Reactome Pathway APEX1 LIG1 +Resolution of Sister Chromatid Cohesion Reactome Pathway AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CCNB1 CCNB2 CDC20 CDCA5 CDCA8 CDK1 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 ERCC6L HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAD21 RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC3 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 WAPAL XPO1 ZW10 ZWILCH ZWINT +Respiratory electron transport Reactome Pathway COX11 COX14 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CYC1 CYCS ETFA ETFB ETFDH LRPPRC MT-CO1 MT-CO2 MT-CO3 MT-CYB MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 SCO1 SCO2 SDHA SDHB SDHC SDHD SURF1 TACO1 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ +Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Reactome Pathway ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP5S COX11 COX14 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CYC1 CYCS ETFA ETFB ETFDH LRPPRC MT-ATP6 MT-ATP8 MT-CO1 MT-CO2 MT-CO3 MT-CYB MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 SCO1 SCO2 SDHA SDHB SDHC SDHD SURF1 TACO1 UCP1 UCP2 UCP3 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ +Response of Mtb to phagocytosis Reactome Pathway LTF MT2748 Rv2238c Rv2895c adhE2 ahpC ahpD bfr bfrB dlaT fgd1 ggtA glbN irtA irtB katG lpdC msrA secA1 secA2 secD secE secF secG secY sodB sodC tpx trx-2 trxA trxB +Response to elevated platelet cytosolic Ca2+ Reactome Pathway A2M ABCC4 ACTN1 ACTN2 ACTN4 ALB ALDOA APOA1 APP BRPF3 CALM1 CALU CAP1 CD36 CD63 CD9 CFD CFL1 CLU EGF F13A1 F5 F8 FGA FGB FGG FIGF FLNA FN1 GAS6 HABP4 HGF HRG HSPA5 IGF1 IGF2 ITGA2B ITGB3 KNG1 LAMP2 LEFTY2 MMRN1 PDGFA PDGFB PECAM1 PF4 PFN1 PLEK PLG POTEKP PPBP PPIA PRKCA PRKCB PRKCG PROS1 PSAP SCG3 SELP SERPINA1 SERPINE1 SERPINF2 SERPING1 SOD1 SPARC SRGN STX4 STXBP3 TF TGFB1 TGFB2 TGFB3 THBS1 TIMP1 TLN1 TMSB4X TTN TUBA4A VCL VEGFA VEGFB VEGFC VWF WDR1 +Retinoid cycle disease events Reactome Pathway NAPEPLD OPN1LW OPN1MW OPN1SW RBP1 RBP4 RLBP1 STRA6 TTR +Retinoid metabolism and transport Reactome Pathway AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE BCO1 BCO2 CLPS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 PLB1 PNLIP RBP1 RBP2 RBP4 RDH11 SDC1 SDC2 SDC3 SDC4 TTR +Retrograde neurotrophin signalling Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA DNAL4 DNM1 DNM2 DNM3 NGF NTRK1 SH3GL2 +Reuptake of GABA Reactome Pathway SLC6A1 SLC6A11 SLC6A12 SLC6A13 +Rev-mediated nuclear export of HIV RNA Reactome Pathway AAAS NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 SEH1L TPR XPO1 rev +Reversal of Alkylation Damage By DNA Dioxygenases Reactome Pathway ALKBH2 ALKBH3 +Reverse Transcription of HIV RNA Reactome Pathway PPIA gag gag-pol rev vif vpr vpu +Reversible hydration of carbon dioxide Reactome Pathway CA1 CA12 CA13 CA14 CA2 CA3 CA4 CA5A CA5B CA6 CA7 CA9 +Rhesus glycoproteins mediate ammonium transport. Reactome Pathway RHAG RHBG RHCG +Rho GTPase cycle Reactome Pathway A2M ABR AKAP13 ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP36 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP44 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 BCR BPGAP1 CDC42 CHN1 CHN2 DEPDC1B DEPDC7 DLC1 ECT2 FAM13A FAM13B FGD1 FGD2 FGD3 FGD4 GDI1 GDI2 GMIP HMHA1 INPP5B ITSN1 KALRN MCF2 MCF2L MYO9A MYO9B NET1 NGEF OBSCN OCRL OPHN1 PIK3R2 PLEKHG2 PLEKHG5 RAC2 RAC3 RACGAP1 RALBP1 RASGRF2 RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOT1 RHOT2 RHOU RHOV SOS1 SOS2 SRGAP1 SRGAP2 SRGAP3 STARD13 STARD8 SYDE1 SYDE2 TAGAP TIAM1 TIAM2 TRIO TRIP10 VAV1 VAV2 VAV3 +Ribosomal scanning and start codon recognition Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H EIF5 FAU RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA +Role of Abl in Robo-Slit signaling Reactome Pathway ABL1 ABL2 CAP1 CAP2 CLASP1 CLASP2 GPC1 ROBO1 SLIT2 +Role of DCC in regulating apoptosis Reactome Pathway APPL1 CASP3 CASP9 DAPK1 DAPK2 DAPK3 DCC MAGED1 UNC5A UNC5B +Role of LAT2/NTAL/LAB on calcium mobilization Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CD19 CD28 CD80 CD86 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GAB2 GRB2 GSK3A GSK3B HBEGF IGHE IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 IRS1 IRS2 KIT KITLG KL KLB LAT2 LCK LYN MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN PTPN11 RICTOR RPS6KB2 SHC1 SOS1 SYK THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 VAV1 +Role of phospholipids in phagocytosis Reactome Pathway CD247 CD3G FCGR1A FCGR2A FCGR3A IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 ITPR1 ITPR2 ITPR3 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PPAPDC1A PPAPDC1B PRKCD PRKCE SYK +Role of second messengers in netrin-1 signaling Reactome Pathway DCC NTN1 PITPNA PLCG1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 +S Phase Reactome Pathway APEX1 CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CCNH CDC25A CDC25B CDC45 CDC6 CDCA5 CDK2 CDK4 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DNA2 ESCO1 ESCO2 FEN1 FZR1 GINS1 GINS2 GINS4 LIG1 MAX MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PDS5A PDS5B POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAD21 RB1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SKP1 SKP2 SMC1A SMC3 STAG1 STAG2 UBA52 UBB UBC WAPAL WEE1 +S33 mutants of beta-catenin aren't phosphorylated Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +S37 mutants of beta-catenin aren't phosphorylated Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +S45 mutants of beta-catenin aren't phosphorylated Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +S6K1 signalling Reactome Pathway EEF2K EIF4B EIF4G1 RPS6 RPS6KB1 +S6K1-mediated signalling Reactome Pathway EEF2K EIF4B EIF4G1 MLST8 MTOR RHEB RPS6 RPS6KB1 RPTOR +SCF(Skp2)-mediated degradation of p27/p21 Reactome Pathway CCNA1 CCNA2 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B CKS1B CUL1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RPS27A SKP1 SKP2 UBA52 UBB UBC +SCF-beta-TrCP mediated degradation of Emi1 Reactome Pathway BTRC CDC20 CUL1 FBXO5 FZR1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SKP1 UBA52 UBB UBC +SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Reactome Pathway FARP2 FES FYN NRP1 PIP5K1C PLXNA1 PLXNA2 PLXNA3 PLXNA4 RAC1 RND1 RRAS SEMA3A TLN1 +SHC activation Reactome Pathway GRB10 INS INSR SHC1 +SHC-mediated cascade Reactome Pathway FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 GRB2 HRAS KL KLB KRAS NRAS SHC1 SOS1 +SHC-mediated signalling Reactome Pathway CDK1 GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SHC1 SHC2 SHC3 SOS1 TYK2 YWHAB +SHC-related events Reactome Pathway CDK1 GRB10 GRB2 HRAS IL6 IL6R IL6ST INS INSR JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SHC1 SHC2 SHC3 SOS1 TYK2 YWHAB +SHC-related events triggered by IGF1R Reactome Pathway CDK1 GRB2 HRAS IGF1 IGF1R IGF2 IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SHC1 SHC2 SHC3 SOS1 TYK2 YWHAB +SHC1 events in EGFR signaling Reactome Pathway CDK1 EGF EGFR GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SHC1 SOS1 TYK2 YWHAB +SHC1 events in ERBB2 signaling Reactome Pathway BTC CDK1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG GRB2 HBEGF HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS NRG1 NRG2 NRG3 NRG4 PTPN11 RAF1 SHC1 SOS1 TYK2 YWHAB +SHC1 events in ERBB4 signaling Reactome Pathway BTC CDK1 ERBB4 EREG GRB2 HBEGF HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS NRG1 NRG2 NRG3 NRG4 PTPN11 RAF1 SHC1 SOS1 TYK2 YWHAB +SIRT1 negatively regulates rRNA Expression Reactome Pathway H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB RRP8 SIRT1 SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP +SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Reactome Pathway LSM10 LSM11 NCBP1 NCBP2 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +SLBP independent Processing of Histone Pre-mRNAs Reactome Pathway LSM10 LSM11 NCBP1 NCBP2 SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +SLC-mediated transmembrane transport Reactome Pathway AAAS ALB APOD AVP CP G6PC G6PC2 G6PC3 GCK GCKR HEPH HK1 HK2 HK3 LCN1 LCN12 LCN15 LCN9 NAGLT1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PDZD11 POM121 RAE1 RANBP2 RHAG RHBG RHCG SEH1L SLC10A6 SLC11A1 SLC11A2 SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 SLC14A1 SLC14A2 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A1 SLC16A10 SLC16A3 SLC16A7 SLC16A8 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC18A1 SLC18A2 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A6 SLC26A7 SLC26A9 SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC31A1 SLC32A1 SLC33A1 SLC34A1 SLC34A2 SLC34A3 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC36A1 SLC36A2 SLC37A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC3A1 SLC3A2 SLC40A1 SLC41A1 SLC41A2 SLC43A1 SLC43A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC47A1 SLC47A2 SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 TPR +SMAC binds to IAPs Reactome Pathway CASP3 CASP7 CASP9 DIABLO XIAP +SMAC-mediated apoptotic response Reactome Pathway CASP3 CASP7 CASP9 DIABLO XIAP +SMAC-mediated dissociation of IAP:caspase complexes Reactome Pathway CASP3 CASP7 CASP9 DIABLO XIAP +SMAD2/3 MH2 Domain Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +SMAD2/3 Phosphorylation Motif Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome Pathway CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B E2F4 E2F5 HDAC1 JUNB MEN1 MYC RBL1 RNF111 RPS27A SERPINE1 SMAD2 SMAD3 SMAD4 SMAD7 SP1 TFDP1 TFDP2 TGIF1 TGIF2 UBA52 UBB UBC WWTR1 +SMAD4 MH2 Domain Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +SOS-mediated signalling Reactome Pathway CDK1 GRB2 HRAS IL6 IL6R IL6ST IRS1 IRS2 JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SOS1 TYK2 YWHAB +SRP-dependent cotranslational protein targeting to membrane Reactome Pathway 7SL RNA (ENSG00000222619) 7SL RNA (ENSG00000222639) DDOST FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRPR SRPRB SSR1 SSR2 SSR3 SSR4 TRAM1 UBA52 +STAT6-mediated induction of chemokines Reactome Pathway STAT6 TBK1 TMEM173 +STING mediated induction of host immune responses Reactome Pathway DDX41 DTX4 IFI16 IRF3 MB21D1 MRE11A NLRP4 PRKDC STAT6 TBK1 TMEM173 TREX1 TRIM21 XRCC5 XRCC6 ZBP1 +SUMO is conjugated to E1 (UBA2:SAE1) Reactome Pathway SAE1 SUMO1 SUMO2 SUMO3 UBA2 +SUMO is proteolytically processed Reactome Pathway SENP1 SENP2 SENP5 SUMO1 SUMO2 SUMO3 +SUMO is transferred from E1 to E2 (UBE2I, UBC9) Reactome Pathway SAE1 SUMO1 SUMO2 SUMO3 UBA2 UBE2I +SUMOylation Reactome Pathway SAE1 SENP1 SENP2 SENP5 SUMO1 SUMO2 SUMO3 UBA2 UBE2I +Scavenging by Class A Receptors Reactome Pathway APOA1 APOB APOE CALR COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COLEC11 COLEC12 FTH1 FTL HSP90B1 MARCO MASP1 MSR1 SCARA5 SCGB3A2 +Scavenging by Class B Receptors Reactome Pathway APOA1 APOB CD36 SAA1 SCARB1 +Scavenging by Class F Receptors Reactome Pathway APOB CALR HSP90AA1 HSPH1 HYOU1 SCARF1 porB +Scavenging by Class H Receptors Reactome Pathway APOB SPARC STAB1 STAB2 +Scavenging of heme from plasma Reactome Pathway ALB AMBP APOA1 APOL1 CD163 HBA1 HBB HP HPR HPX IGHA1 IGHA2 IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-36 IGLV1-40 IGLV1-44 IGLV10-54 IGLV11-55 IGLV2-11 IGLV2-18 IGLV2-23 IGLV2-33 IGLV3-12 IGLV3-16 IGLV3-22 IGLV3-25 IGLV3-27 IGLV4-3 IGLV4-60 IGLV4-69 IGLV5-37 IGLV5-45 IGLV7-43 IGLV7-46 IGLV8-61 LRP1 +Sema3A PAK dependent Axon repulsion Reactome Pathway CFL1 FES FYN HSP90AA1 HSP90AB1 LIMK1 NRP1 PAK1 PAK2 PAK3 PLXNA1 PLXNA2 PLXNA3 PLXNA4 RAC1 SEMA3A +Sema4D in semaphorin signaling Reactome Pathway ARHGAP35 ARHGEF11 ARHGEF12 CDC42 ERBB2 LIMK1 LIMK2 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PLXNB1 RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK2 RRAS SEMA4D +Sema4D induced cell migration and growth-cone collapse Reactome Pathway ARHGEF11 ARHGEF12 CDC42 ERBB2 LIMK1 LIMK2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PLXNB1 RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK2 SEMA4D +Sema4D mediated inhibition of cell attachment and migration Reactome Pathway ARHGAP35 MET PLXNB1 RAC1 RHOA RND1 RRAS SEMA4D +Semaphorin interactions Reactome Pathway ARHGAP35 ARHGEF11 ARHGEF12 CD72 CDC42 CDK5 CDK5R1 CFL1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 ERBB2 FARP2 FES FYN GSK3B HSP90AA1 HSP90AB1 ITGA1 ITGB1 LIMK1 LIMK2 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NRP1 PAK1 PAK2 PAK3 PIP5K1C PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB3 PLXNC1 PLXND1 PTPRC RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK2 RRAS SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A TLN1 TREM2 TYROBP +Senescence-Associated Secretory Phenotype (SASP) Reactome Pathway ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNA1 CCNA2 CDC16 CDC23 CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CEBPB CXCL8 EHMT1 EHMT2 FOS FZR1 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB IGFBP7 IL1A IL6 IL8 JUN MAPK1 MAPK3 MAPK7 NFKB1 RELA RPS27A RPS6KA1 RPS6KA2 RPS6KA3 STAT3 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 +Separation of Sister Chromatids Reactome Pathway AHCTF1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA5 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 ERCC6L ESPL1 HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG1 RAD21 RANBP2 RANGAP1 RCC2 RPS27 RPS27A SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SMC1A SMC3 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 WAPAL XPO1 ZW10 ZWILCH ZWINT +Serine biosynthesis Reactome Pathway PHGDH PSAT1 PSPH +Serotonin Neurotransmitter Release Cycle Reactome Pathway BZRAP1 CPLX1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +Serotonin and melatonin biosynthesis Reactome Pathway AANAT ASMT DDC TPH1 TPH2 +Serotonin clearance from the synaptic cleft Reactome Pathway ALDH2 MAOA +Serotonin receptors Reactome Pathway HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 +Sialic acid metabolism Reactome Pathway CMAS CTSA GLB1 GNE NANP NANS NEU1 NEU2 NEU3 NEU4 NPL SLC17A5 SLC35A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 +Signal Transduction Reactome Pathway A2M AATF ABCA4 ABI1 ABI2 ABR ACKR1 ACKR2 ACKR3 ACKR4 ACVR1B ACVR1C ACVR2A ACVR2B ADAM10 ADAM12 ADAM17 ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADH1A ADH1C ADH4 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 AES AGO1 AGO2 AGO3 AGO4 AGRN AGT AGTR1 AGTR2 AKAP13 AKR1B10 AKR1C1 AKR1C3 AKR1C4 AKT1 AKT1S1 AKT2 AKT3 ALDH1A1 ALDH1A2 ALDH1A3 AMER1 AMOT AMOTL1 AMOTL2 ANXA1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APBB1IP APC APH1A APH1B APLN APLNR APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE APP ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP36 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP44 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ASH2L ATF1 ATP2A1 ATP2A2 ATP2A3 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H AVP AVPR1A AVPR1B AVPR2 AXIN1 AXIN2 AXL B4GALT1 BAD BAIAP2 BAMBI BCAR1 BCL2L11 BCL9 BCL9L BCO1 BCO2 BCR BDKRB1 BDKRB2 BMP2 BMPR1A BMPR1B BMPR2 BOC BPGAP1 BRAF BRK1 BRS3 BTC BTRC C3 C3AR1 C5 C5AR1 C5AR2 CAB39 CAB39L CALCA CALCB CALCR CALCRL CALM1 CAMK2A CAMK4 CASP2 CASP3 CASP9 CASR CAV1 CBL CBY1 CCDC88C CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCNC CCND1 CCNT1 CCNT2 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD19 CD28 CD55 CD80 CD86 CD97 CDC37 CDC42 CDC73 CDH5 CDK1 CDK5 CDK8 CDK9 CDKN1A CDKN1B CDKN2B CDON CER1 CGA CGN CHD8 CHEK1 CHN1 CHN2 CHRDL1 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CHUK CLPS CLTA CLTB CLTC CMA1 CNGA1 CNGB1 CNR1 CNR2 CNTN1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CPT1A CPT1B CRABP1 CRABP2 CREB1 CREBBP CRH CRHR1 CRHR2 CRK CRKL CSF2 CSF2RA CSF2RB CSH1 CSK CSN2 CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTBP2 CTNNA1 CTNNB1 CTNNBIP1 CTNND1 CUL1 CUL3 CUL5 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXXC4 CYBA CYBB CYFIP2 CYP26A1 CYP26B1 CYP26C1 CYSLTR1 CYSLTR2 DAAM1 DACT1 DAGLA DAGLB DEPDC1B DEPDC7 DERL2 DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DHH DHRS3 DHRS4 DHRS9 DISP2 DKK1 DKK2 DKK4 DLAT DLC1 DLD DLK1 DLL1 DLL4 DNAL4 DNER DNM1 DNM2 DNM3 DOCK1 DOK1 DRAP1 DRD1 DRD2 DRD3 DRD4 DRD5 DTX1 DTX2 DTX4 DUSP3 DUSP4 DUSP6 DUSP7 DVL1 DVL2 DVL3 DYNC2H1 DZIP1 E2F1 E2F3 E2F4 E2F5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB EEF2K EFCAB7 EGF EGFR EIF4B EIF4E EIF4EBP1 EIF4G1 ELK1 ELMO1 ELMO2 EMR1 EMR2 EMR3 EP300 EPN1 EPS15 EPS15L1 ERBB2 ERBB2IP ERBB3 ERBB4 EREG ERLEC1 ESR1 EVC EVC2 F11R F2 F2R F2RL1 F2RL2 F2RL3 FABP5 FAM13A FAM13B FBXW7 FCER2 FER FES FFAR1 FFAR2 FFAR3 FFAR4 FGA FGB FGD1 FGD2 FGD3 FGD4 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FGG FIGF FKBP1A FLT1 FLT4 FN1 FNTA FNTB FOXH1 FOXO1 FOXO3 FOXO4 FPR1 FPR2 FPR3 FRAT1 FRAT2 FRS2 FRS3 FSHB FSHR FST FSTL1 FSTL3 FURIN FUZ FYN FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GAB1 GAB2 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAS1 GAS8 GAST GCG GCGR GDI1 GDI2 GFAP GH1 GH2 GHR GHRH GHRHR GHRL GHSR GIP GIPR GLI1 GLI2 GLI3 GLP1R GLP2R GMIP GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPER1 GPR132 GPR161 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRAP GRAP2 GRB10 GRB2 GRB7 GREM2 GRK1 GRK5 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR GSK3A GSK3B GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F GZMB H2AFB1 H2AFX H2AFZ H2BFS H3F3A HBEGF HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HEBP1 HECW1 HES1 HES5 HEY1 HEY2 HEYL HGS HHAT HHIP HIF1A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 HMHA1 HRAS HRH1 HRH2 HRH3 HRH4 HSD17B1 HSD17B6 HSP90AA1 HSPB1 HSPG2 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IFT122 IFT140 IFT172 IFT52 IFT57 IFT88 IGF1 IGF1R IGF2 IHH IKBKB IL17RD IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST INHBA INHBB INPP5B INS INSL3 INSL5 INSR INTU IQCE IRAK1 IRS1 IRS2 IRS4 ITCH ITGA2B ITGAV ITGB3 ITGB3BP ITPR1 ITPR2 ITPR3 ITSN1 JAG1 JAG2 JAK1 JAK2 JAK3 JUN JUNB JUP KALRN KAT2A KAT2B KAT5 KDR KIDINS220 KIF3A KIF7 KISS1 KISS1R KIT KITLG KL KLB KLHL12 KMT2D KNG1 KRAS KREMEN1 KREMEN2 LATS1 LATS2 LCK LDLR LEF1 LEO1 LEP LEPR LFNG LGR4 LGR5 LGR6 LHB LHCGR LINGO1 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LPL LRAT LRIG1 LRP1 LRP10 LRP12 LRP2 LRP5 LRP6 LRP8 LTB4R LTB4R2 LYN MAG MAGED1 MAML1 MAML2 MAML3 MAMLD1 MAP2K1 MAP2K2 MAP2K5 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPKAP1 MAPKAPK2 MAPKAPK3 MATK MC1R MC2R MC3R MC4R MC5R MCF2 MCF2L MCHR1 MCHR2 MDK MDM2 MEF2A MEF2C MEN1 METAP1 METAP2 MFNG MGLL MIB1 MIB2 MIR150 MIR181C MIR200B MIR200C MIR206 MIR26A1 MIR26A2 MIR302A MIR34A MIR34B MIR34C MIR449A MIR449B MIR449C MIR92b MKNK1 MKS1 MLN MLNR MLST8 MMP3 MMP9 MOB1A MOB1B MOV10 MT-RNR2 MTMR4 MTNR1A MTNR1B MTOR MYC MYD88 MYO7A MYO9A MYO9B NAPEPLD NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCOR1 NCOR2 NCSTN NEDD4 NEDD4L NEDD8 NET1 NEURL1 NEURL1B NFATC1 NFKB1 NFKBIA NGEF NGF NGFR NGFRAP1 NLK NMB NMBR NMS NMT1 NMT2 NMU NMUR1 NMUR2 NOG NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NOTUM NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPHP4 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 NRP1 NRP2 NTRK1 NTRK2 NTS NTSR1 NTSR2 NUMB OBSCN OCRL OFD1 OMG OPHN1 OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AC1P OR10AD1 OR10AG1 OR10C1 OR10D3 OR10D4P OR10G2 OR10G3 OR10G4 OR10G6 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J4 OR10J5 OR10J6P OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR11H1 OR11H2 OR11H4 OR11H6 OR11H7 OR11L1 OR12D2 OR12D3 OR13A1 OR13C2 OR13C3 OR13C4 OR13C5 OR13C8 OR13C9 OR13D1 OR13F1 OR13G1 OR13H1 OR13J1 OR14A16 OR14A2 OR14C36 OR14I1 OR14J1 OR14K1 OR14L1P OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1E3 OR1F1 OR1F12 OR1F2P OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1P1 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AG2 OR2AJ1 OR2AK2 OR2AP1 OR2AT4 OR2B11 OR2B2 OR2B3 OR2B6 OR2B8P OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2H2 OR2I1P OR2J1 OR2J2 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L5 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2T6 OR2T7 OR2T8 OR2V1 OR2V2 OR2W1 OR2W3 OR2W5 OR2W6P OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A4P OR4A5 OR4A8P OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C45 OR4C46 OR4C5 OR4C6 OR4D1 OR4D10 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E1 OR4E2 OR4F15 OR4F17 OR4F21 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K3 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N4 OR4N5 OR4P4 OR4Q2 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F1 OR51F2 OR51G1 OR51G2 OR51H1P OR51I1 OR51I2 OR51J1 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A4 OR52A5 OR52B2 OR52B4 OR52B6 OR52D1 OR52E1 OR52E2 OR52E4 OR52E5 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52L2P OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52P1P OR52R1 OR52W1 OR52Z1 OR56A1 OR56A3 OR56A4 OR56A5 OR56B1 OR56B2P OR56B4 OR5A1 OR5A2 OR5AC1 OR5AC2 OR5AK2 OR5AK3P OR5AL1 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B21 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5G3 OR5H1 OR5H14 OR5H15 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5K3 OR5K4 OR5L1 OR5L2 OR5M1 OR5M10 OR5M11 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6C6 OR6C65 OR6C68 OR6C70 OR6C74 OR6C75 OR6C76 OR6F1 OR6J1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6P1 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A2P OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7E24 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B2 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8G1 OR8G2 OR8G5 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J2 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A1P OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 OS9 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P4HB PAG1 PAK1 PAK2 PAK3 PARD3 PARD6A PARP1 PCSK5 PCSK6 PDE10A PDE11A PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE6A PDE6B PDE6G PDE7A PDE7B PDE8A PDE8B PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDPK1 PDYN PENK PF4 PFN1 PGF PGR PHLPP1 PHLPP2 PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIP5K1B PLA2G4A PLAT PLB1 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLEKHG2 PLEKHG5 PLG PLXNB1 PMCH PMEPA1 PNLIP PNOC POFUT1 POGLUT1 POMC PORCN PPARD PPBP PPEF1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3CC PPP3R1 PPY PRDM4 PRICKLE1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKG1 PRKG2 PRL PRLH PRLHR PRLR PROK1 PROK2 PROKR1 PROKR2 PSAP PSEN2 PSENEN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTAFR PTCH1 PTCH2 PTEN PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PTK2 PTK2B PTPN1 PTPN11 PTPN6 PTPRU PXN PYGO1 PYGO2 PYY QRFP QRFPR RAB6A RAC1 RAC2 RAC3 RACGAP1 RAF1 RALA RALB RALBP1 RALGDS RAMP1 RAMP2 RAMP3 RAP1A RAP1B RAPGEF1 RAPGEF3 RAPGEF4 RARA RARB RARG RASA1 RASGRF2 RASGRP1 RASGRP2 RBBP5 RBL1 RBP1 RBP2 RBP3 RBP4 RBPJ RBX1 RCVRN RDH10 RDH11 RDH12 RDH13 RDH14 RDH16 RDH5 RDH8 RELA RFNG RGR RGS1 RGS10 RGS11 RGS12 RGS14 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RGS9BP RHEB RHO RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOT1 RHOT2 RHOU RHOV RICTOR RIPK2 RIT1 RIT2 RLBP1 RLN2 RLN3 RNF111 RNF146 RNF41 RNF43 ROCK1 ROCK2 ROR1 ROR2 RPE65 RPGRIP1L RPS27A RPS6 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB1 RPS6KB2 RPTOR RRH RSPO1 RSPO2 RSPO3 RSPO4 RTN4 RUVBL1 RXFP1 RXFP2 RXFP3 RXFP4 RXRA RXRB RXRG RYK S100B S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SAG SAV1 SCRIB SCT SCTR SCUBE2 SDC1 SDC2 SDC3 SDC4 SDR16C5 SDR9C7 SEL1L SERPINE1 SFRP1 SFRP2 SH2B1 SH2B2 SH2B3 SH2D2A SH3GL2 SH3KBP1 SHB SHC1 SHC2 SHC3 SHH SKI SKIL SKP1 SLC24A1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMARCA4 SMO SMPD2 SMURF1 SMURF2 SNW1 SNX3 SOCS1 SOCS3 SOCS6 SORCS3 SOS1 SOS2 SOST SP1 SPHK1 SPOP SPOPL SPP1 SPRY1 SPRY2 SQSTM1 SRC SRGAP1 SRGAP2 SRGAP3 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 ST3GAL3 ST3GAL4 ST3GAL6 STAM STAM2 STARD13 STARD8 STAT1 STAT3 STAT5A STAT5B STAT6 STK11 STK3 STK4 STRA6 STRADA STRADB STRAP STUB1 SUCNR1 SUFU SYDE1 SYDE2 SYK SYVN1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAB2 TAC1 TAC3 TACR1 TACR2 TACR3 TAGAP TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBL1X TBL1XR1 TBXA2R TCF4 TCF7 TCF7L1 TCF7L2 TCIRG1 TEC TERT TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 THBS1 THBS2 THBS3 THBS4 THEM4 TIAM1 TIAM2 TJP1 TJP2 TLE1 TLE2 TLE3 TLE4 TLN1 TLR9 TMED2 TMED5 TNKS TNKS2 TNRC6A TNRC6B TNRC6C TP53 TRAF6 TRAT1 TRH TRHR TRIB3 TRIM33 TRIO TRIP10 TRPC3 TRPC6 TRPC7 TRRAP TSC1 TSC2 TSHB TSHR TTC21B TTR TULP3 TYK2 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 ULK3 USP15 USP34 USP8 USP9X UTS2 UTS2B UTS2R VANGL2 VAV1 VAV2 VAV3 VCP VEGFA VEGFB VEGFC VIP VIPR1 VIPR2 VPS26A VPS29 VPS35 VWF WASF1 WASF2 WASF3 WDR19 WDR35 WIF1 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WWC1 WWOX WWP1 WWTR1 XCL1 XCL2 XCR1 XIAP XPO1 YAP1 YES1 YWHAB YWHAE YWHAZ ZFYVE16 ZFYVE9 ZNRF3 +Signal amplification Reactome Pathway GNA11 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK14 P2RY1 P2RY12 PLA2G4A SRC TBXA2R +Signal attenuation Reactome Pathway CRK DOK1 GRB10 GRB2 INS INSR IRS1 IRS2 MAPK1 MAPK3 SHC1 SHC2 SHC3 SOS1 +Signal regulatory protein (SIRP) family interactions Reactome Pathway CD47 FYB GRB2 PTK2 PTK2B PTPN11 PTPN6 SIRPA SIRPB1 SIRPG SKAP2 SRC TYROBP +Signal transduction by L1 Reactome Pathway CSNK2A1 CSNK2A2 CSNK2B EGFR FGFR1 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 L1CAM MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NRP1 PAK1 RAC1 VAV2 +Signaling by Activin Reactome Pathway ACVR1B ACVR1C ACVR2A ACVR2B DRAP1 FOXH1 FST FSTL3 INHBA INHBB SMAD2 SMAD3 SMAD4 +Signaling by BMP Reactome Pathway ACVR2A ACVR2B BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GREM2 NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 UBE2D1 UBE2D3 ZFYVE16 +Signaling by EGFR Reactome Pathway ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 BAD BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HGS HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAG1 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 PXN RAF1 RICTOR RPS27A RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by EGFR in Cancer Reactome Pathway ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 BAD BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDC37 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HGS HRAS HSP90AA1 IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAG1 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 PXN RAF1 RICTOR RPS27A RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by EGFRvIII in Cancer Reactome Pathway ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 BAD BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDC37 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HGS HRAS HSP90AA1 IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAG1 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 PXN RAF1 RICTOR RPS27A RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by ERBB2 Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDC37 CDK1 CDKN1A CDKN1B CHUK CREB1 CUL5 EGF EGFR ERBB2 ERBB2IP ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GRB7 GSK3A GSK3B HBEGF HRAS HSP90AA1 IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MATK MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RICTOR RNF41 RPS27A RPS6KB2 SHC1 SOS1 SRC STUB1 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC USP8 VAV1 YES1 YWHAB +Signaling by ERBB4 Reactome Pathway ADAM17 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 APH1A APH1B BAD BTC BTRC CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 CSH1 CSN2 CUL1 CXCL12 EGF EGFR ERBB2 ERBB3 ERBB4 EREG ESR1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GFAP GH1 GH2 GHR GRB2 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 ITCH JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NCOR1 NCSTN NEDD4 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PGR PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRL PRLR PSEN2 PSENEN PTEN PTPN11 RAF1 RBX1 RICTOR RPS27A RPS6KB2 S100B SH2B1 SHC1 SKP1 SOS1 STAT5A STAT5B TAB2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 WWOX WWP1 YAP1 YWHAB +Signaling by FGFR Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BRAF BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HRAS IL17RD IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MKNK1 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PPP2CA PPP2CB PPP2R1A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RICTOR RPS27A RPS6KB2 SHC1 SOS1 SPRY2 SRC THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by FGFR in disease Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCR BRAF BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CNTRL CPSF6 CREB1 CUX1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 FYN GAB1 GAB2 GRB2 GSK3A GSK3B HBEGF HRAS IL17RD IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRRFIP1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MKNK1 MLST8 MOV10 MTOR MYO18A NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PPP2CA PPP2CB PPP2R1A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RICTOR RPS27A RPS6KB2 SHC1 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TRIM24 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB ZMYM2 +Signaling by FGFR mutants Reactome Pathway BCR CNTRL CPSF6 CUX1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GAB2 GRB2 HRAS KRAS LRRFIP1 MYO18A NRAS PIK3CA PIK3R1 PLCG1 SOS1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +Signaling by FGFR1 amplification mutants Reactome Pathway FGFR1 +Signaling by FGFR1 fusion mutants Reactome Pathway BCR CNTRL CPSF6 CUX1 FGFR1OP FGFR1OP2 GAB2 GRB2 LRRFIP1 MYO18A PIK3CA PIK3R1 PLCG1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +Signaling by FGFR1 mutants Reactome Pathway BCR CNTRL CPSF6 CUX1 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 GAB2 GRB2 LRRFIP1 MYO18A PIK3CA PIK3R1 PLCG1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +Signaling by FGFR2 amplification mutants Reactome Pathway FGFR2 +Signaling by FGFR2 mutants Reactome Pathway FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 +Signaling by FGFR3 mutants Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 +Signaling by FGFR4 mutants Reactome Pathway FGFR4 +Signaling by GPCR Reactome Pathway ABR ACKR1 ACKR2 ACKR3 ACKR4 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 AGT AGTR1 AGTR2 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLN APLNR APP ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CALM1 CAMK4 CASR CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD55 CD97 CDC42 CDK1 CDK5 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CREB1 CRH CRHR1 CRHR2 CSF2 CSF2RA CSF2RB CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DHH DRD1 DRD2 DRD3 DRD4 DRD5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB EGFR EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FGD1 FGD2 FGD3 FGD4 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GAB2 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPBAR1 GPER1 GPR132 GPR17 GPR18 GPR31 GPR37 GPR37L1 GPR39 GPR4 GPR55 GPR65 GPR68 GPRC6A GRB2 GRK5 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HBEGF HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRAS HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST INSL3 INSL5 ITPR1 ITPR2 ITPR3 ITSN1 JAK1 JAK2 JAK3 KALRN KISS1 KISS1R KNG1 KRAS LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK7 MC1R MC2R MC3R MC4R MC5R MCF2 MCF2L MCHR1 MCHR2 MGLL MLN MLNR MMP3 MT-RNR2 MTNR1A MTNR1B NET1 NGEF NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NRAS NTS NTSR1 NTSR2 OBSCN OPN1LW OPN1MW OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AC1P OR10AD1 OR10AG1 OR10C1 OR10D3 OR10D4P OR10G2 OR10G3 OR10G4 OR10G6 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J4 OR10J5 OR10J6P OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR11H1 OR11H2 OR11H4 OR11H6 OR11H7 OR11L1 OR12D2 OR12D3 OR13A1 OR13C2 OR13C3 OR13C4 OR13C5 OR13C8 OR13C9 OR13D1 OR13F1 OR13G1 OR13H1 OR13J1 OR14A16 OR14A2 OR14C36 OR14I1 OR14J1 OR14K1 OR14L1P OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1E3 OR1F1 OR1F12 OR1F2P OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1P1 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AG2 OR2AJ1 OR2AK2 OR2AP1 OR2AT4 OR2B11 OR2B2 OR2B3 OR2B6 OR2B8P OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2H2 OR2I1P OR2J1 OR2J2 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L5 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2T6 OR2T7 OR2T8 OR2V1 OR2V2 OR2W1 OR2W3 OR2W5 OR2W6P OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A4P OR4A5 OR4A8P OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C45 OR4C46 OR4C5 OR4C6 OR4D1 OR4D10 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E1 OR4E2 OR4F15 OR4F17 OR4F21 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K3 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N4 OR4N5 OR4P4 OR4Q2 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F1 OR51F2 OR51G1 OR51G2 OR51H1P OR51I1 OR51I2 OR51J1 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A4 OR52A5 OR52B2 OR52B4 OR52B6 OR52D1 OR52E1 OR52E2 OR52E4 OR52E5 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52L2P OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52P1P OR52R1 OR52W1 OR52Z1 OR56A1 OR56A3 OR56A4 OR56A5 OR56B1 OR56B2P OR56B4 OR5A1 OR5A2 OR5AC1 OR5AC2 OR5AK2 OR5AK3P OR5AL1 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B21 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5G3 OR5H1 OR5H14 OR5H15 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5K3 OR5K4 OR5L1 OR5L2 OR5M1 OR5M10 OR5M11 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6C6 OR6C65 OR6C68 OR6C70 OR6C74 OR6C75 OR6C76 OR6F1 OR6J1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6P1 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A2P OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7E24 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B2 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8G1 OR8G2 OR8G5 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J2 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A1P OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDE10A PDE11A PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLEKHG5 PLXNB1 PMCH PNOC POMC PPBP PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PPY PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTCH1 PTCH2 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PTPN11 PYY QRFP QRFPR RAC1 RAC2 RAF1 RAMP1 RAMP2 RAMP3 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS10 RGS11 RGS12 RGS14 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RHOA RHOB RHOC RHOG RLN2 RLN3 ROCK1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHC1 SHH SMO SOS1 SOS2 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR3 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR TYK2 UTS2 UTS2B UTS2R VAV1 VAV2 VAV3 VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 YWHAB +Signaling by Hedgehog Reactome Pathway ADAM17 ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 ARRB1 ARRB2 BOC BTRC CDC73 CDON CSNK1A1 CUL1 CUL3 DERL2 DHH DISP2 DYNC2H1 DZIP1 EFCAB7 ERLEC1 EVC EVC2 FUZ GAS1 GAS8 GLI1 GLI2 GLI3 GNAS GPC5 GPR161 GSK3B HHAT HHIP IFT122 IFT140 IFT172 IFT52 IFT57 IFT88 IHH INTU IQCE ITCH KIF3A KIF7 MKS1 NOTUM NUMB OFD1 OS9 P4HB PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTCH1 PTCH2 RBX1 RPGRIP1L RPS27A SCUBE2 SEL1L SHH SKP1 SMO SMURF1 SMURF2 SPOP SPOPL SUFU SYVN1 TTC21B TULP3 UBA52 UBB UBC ULK3 VCP WDR19 WDR35 +Signaling by Hippo Reactome Pathway AMOT AMOTL1 AMOTL2 CASP3 DVL2 LATS1 LATS2 MOB1A MOB1B NPHP4 SAV1 STK3 STK4 TJP1 TJP2 WWC1 WWTR1 YAP1 YWHAB YWHAE +Signaling by Insulin receptor Reactome Pathway AKT2 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CAB39 CAB39L CDK1 CRK DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB10 GRB2 HRAS IL6 IL6R IL6ST INS INSR IRS1 IRS2 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB TCIRG1 THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +Signaling by Interleukins Reactome Pathway BLNK BTRC CASP1 CBL CDK1 CHUK CRK CRKL CSF2 CSF2RA CSF2RB CUL1 FYN GAB2 GRB2 HCK HGF HRAS IKBKB IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPP5D INPPL1 IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JAK3 KRAS LCK LYN MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK3 MYD88 NFKB1 NFKB2 NOD1 NOD2 NRAS PELI1 PELI2 PELI3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACA PTK2B PTPN11 PTPN6 RAF1 RAPGEF1 RBX1 RELA RIPK2 SHC1 SKP1 SOCS3 SOS1 SQSTM1 STAT1 STAT3 STAT5A STAT5B SYK TAB1 TAB2 TAB3 TEC TNIP2 TOLLIP TRAF6 TYK2 UBE2N UBE2V1 VAV1 YES1 YWHAB YWHAZ +Signaling by Leptin Reactome Pathway CDK1 HRAS IL6 IL6R IL6ST IRS1 IRS2 JAK1 JAK2 KRAS LEP LEPR MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PTPN11 RAF1 SH2B1 SOCS3 STAT3 STAT5A STAT5B TYK2 YWHAB +Signaling by Ligand-Responsive EGFR Variants in Cancer Reactome Pathway ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 BAD BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDC37 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HGS HRAS HSP90AA1 IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAG1 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 PXN RAF1 RICTOR RPS27A RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by NODAL Reactome Pathway ACVR1B ACVR1C ACVR2A ACVR2B CER1 CFC1 DRAP1 FOXH1 FOXO3 FURIN GDF1 LEFTY1 LEFTY2 NODAL PCSK6 SMAD2 SMAD3 SMAD4 TDGF1 +Signaling by NOTCH Reactome Pathway ADAM10 ADAM17 AGO1 AGO2 AGO3 AGO4 APH1A APH1B ARRB1 ARRB2 ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCNC CCND1 CDK8 CNTN1 CREB1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 E2F1 E2F3 EP300 FBXW7 FCER2 FURIN GZMB HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 JUN KAT2A KAT2B LFNG MAML1 MAML2 MAML3 MAMLD1 MDK MFNG MIB1 MIB2 MIR150 MIR181C MIR200B MIR200C MIR206 MIR302A MIR34A MIR34B MIR34C MIR449A MIR449B MIR449C MOV10 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUMB POFUT1 POGLUT1 PSEN2 PSENEN RAB6A RBPJ RBX1 RFNG RPS27A SEL1L SKP1 SNW1 ST3GAL3 ST3GAL4 ST3GAL6 TBL1X TBL1XR1 TFDP1 TFDP2 TLE1 TLE2 TLE3 TLE4 TMED2 TNRC6A TNRC6B TNRC6C TP53 UBA52 UBB UBC +Signaling by NOTCH1 Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH1 HD Domain Mutants in Cancer Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH1 PEST Domain Mutants in Cancer Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH1 in Cancer Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Reactome Pathway ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +Signaling by NOTCH2 Reactome Pathway ADAM10 APH1A APH1B CNTN1 CREB1 DLL1 DLL4 EP300 FCER2 GZMB HES1 HES5 JAG1 JAG2 MAML1 MAML2 MAML3 MAMLD1 MDK MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH2 PSEN2 PSENEN RBPJ RPS27A UBA52 UBB UBC +Signaling by NOTCH3 Reactome Pathway ADAM10 APH1A APH1B DLL1 DLL4 JAG1 JAG2 NCSTN NOTCH3 PSEN2 PSENEN +Signaling by NOTCH4 Reactome Pathway ADAM10 APH1A APH1B DLL1 DLL4 JAG1 JAG2 NCSTN NOTCH4 PSEN2 PSENEN +Signaling by Overexpressed Wild-Type EGFR in Cancer Reactome Pathway ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF7 BAD BTC CALM1 CAMK4 CASP9 CBL CD19 CD28 CD80 CD86 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HGS HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PAG1 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 PXN RAF1 RICTOR RPS27A RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 UBA52 UBB UBC VAV1 YWHAB +Signaling by PDGF Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCAR1 BTC CALM1 CAMK4 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CREB1 CRK CRKL EGF EGFR ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FURIN FYN GAB1 GRB2 GRB7 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 ITPR1 ITPR2 ITPR3 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NCK1 NCK2 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLAT PLCG1 PLG PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN PTPN11 RAF1 RAPGEF1 RASA1 RICTOR RPS6KB2 SOS1 SPP1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THBS1 THBS2 THBS3 THBS4 THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 VAV1 YWHAB +Signaling by Retinoic Acid Reactome Pathway ADH1A ADH1C ADH4 AKR1C3 ALDH1A1 ALDH1A2 ALDH1A3 CPT1A CPT1B CRABP1 CRABP2 CYP26A1 CYP26B1 CYP26C1 DHRS3 DHRS4 DHRS9 DLAT DLD FABP5 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PPARD RARA RARB RARG RDH10 RDH11 RDH13 RDH14 RDH16 RDH5 RXRA RXRB RXRG SDR16C5 +Signaling by Rho GTPases Reactome Pathway A2M ABR AKAP13 ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP36 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP44 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 BCR BPGAP1 CDC42 CHN1 CHN2 DEPDC1B DEPDC7 DLC1 ECT2 FAM13A FAM13B FGD1 FGD2 FGD3 FGD4 GDI1 GDI2 GMIP HMHA1 INPP5B ITSN1 KALRN MCF2 MCF2L MYO9A MYO9B NET1 NGEF OBSCN OCRL OPHN1 PIK3R2 PLEKHG2 PLEKHG5 RAC2 RAC3 RACGAP1 RALBP1 RASGRF2 RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOT1 RHOT2 RHOU RHOV SOS1 SOS2 SRGAP1 SRGAP2 SRGAP3 STARD13 STARD8 SYDE1 SYDE2 TAGAP TIAM1 TIAM2 TRIO TRIP10 VAV1 VAV2 VAV3 +Signaling by Robo receptor Reactome Pathway ABL1 ABL2 ARHGAP39 CAP1 CAP2 CDC42 CLASP1 CLASP2 ENAH EVL GPC1 NCK1 NCK2 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PFN1 PFN2 RAC1 ROBO1 ROBO2 ROBO3 SLIT2 SOS1 SOS2 SRGAP1 SRGAP2 SRGAP3 VASP +Signaling by SCF-KIT Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CBL CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHEK1 CHUK CMA1 CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FER FES FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 GSK3A GSK3B HBEGF HRAS IL6 IL6R IL6ST IRS1 IRS2 JAK1 JAK2 KIT KITLG KL KLB KRAS LCK LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MMP9 MOV10 MTOR NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKCA PTEN PTPN11 PTPN6 PTPRU RAC1 RAF1 RICTOR RPS6KB2 SH2B2 SH2B3 SOCS1 SOCS6 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TSC2 TYK2 VAV1 YES1 YWHAB +Signaling by TGF-beta Receptor Complex Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Signaling by TGF-beta Receptor Complex in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Reactome Pathway AKT2 CAB39 CAB39L CDK1 DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 HRAS IGF1 IGF1R IGF2 IL6 IL6R IL6ST IRS1 IRS2 IRS4 JAK1 JAK2 KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTPN11 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 TYK2 YWHAB +Signaling by VEGF Reactome Pathway ABI1 ABI2 AKT1 AKT2 AKT3 AXL BAIAP2 BCAR1 BRK1 CALM1 CAV1 CDC42 CDH5 CDK1 CRK CTNNA1 CTNNB1 CTNND1 CYBA CYBB CYFIP2 DOCK1 ELMO1 ELMO2 FIGF FLT1 FLT4 FYN HRAS HSP90AA1 HSPB1 IL6 IL6R IL6ST ITGAV ITGB3 ITPR1 ITPR2 ITPR3 JAK1 JAK2 JUP KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAP1 MAPKAPK2 MAPKAPK3 MLST8 MTOR NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NOS3 NRAS NRP1 NRP2 PAK1 PAK2 PAK3 PDPK1 PGF PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCZ PTK2 PTK2B PTPN11 PXN RAC1 RAF1 RASA1 RHOA RICTOR ROCK1 ROCK2 SH2D2A SHB SHC2 SPHK1 SRC THEM4 TRIB3 TYK2 VAV1 VAV2 VAV3 VEGFA VEGFB VEGFC WASF1 WASF2 WASF3 YWHAB +Signaling by WNT in cancer Reactome Pathway AES AKT1 AKT2 AMER1 APC ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CAV1 CBY1 CCDC88C CDC73 CHD8 CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTBP2 CTNNB1 CTNNBIP1 CUL1 CUL3 CXXC4 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD4 FZD5 FZD6 FZD8 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MEN1 MYC PIP5K1B PORCN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RBBP5 RBX1 RNF146 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SFRP1 SFRP2 SKP1 SMARCA4 SMURF2 SNX3 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TMED5 TNKS TNKS2 TRRAP UBA52 UBB UBC USP34 USP8 VPS26A VPS29 VPS35 WIF1 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XIAP XPO1 YWHAZ ZNRF3 +Signaling by Wnt Reactome Pathway AES AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AMER1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APC ARRB2 ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CALM1 CAMK2A CAV1 CBY1 CCDC88C CDC73 CHD8 CLTA CLTB CLTC CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTBP2 CTNNB1 CTNNBIP1 CUL1 CUL3 CXXC4 DAAM1 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 GNAO1 GNAT2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 ITPR1 ITPR2 ITPR3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MAP3K7 MEN1 MIR92b MOV10 MYC NFATC1 NLK PARD6A PDE6A PDE6B PDE6G PFN1 PIP5K1B PLCB1 PLCB2 PLCB3 PORCN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3R1 PRICKLE1 PRKCA PRKCB PRKCG PRKG1 PRKG2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RAC1 RAC2 RAC3 RBBP5 RBX1 RHOA RNF146 RNF43 ROR1 ROR2 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SCRIB SFRP1 SFRP2 SKP1 SMARCA4 SMURF1 SMURF2 SNX3 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TMED5 TNKS TNKS2 TNRC6A TNRC6B TNRC6C TRRAP UBA52 UBB UBC USP34 USP8 VANGL2 VPS26A VPS29 VPS35 WIF1 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XIAP XPO1 YWHAZ ZNRF3 +Signaling by activated point mutants of FGFR1 Reactome Pathway FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 +Signaling by activated point mutants of FGFR3 Reactome Pathway FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 +Signaling by the B Cell Receptor (BCR) Reactome Pathway AGO1 AGO2 AGO3 AGO4 AKT1 AKT1S1 AKT2 AKT3 BAD BCL10 BLK BLNK BTC BTK BTRC CALM1 CARD11 CASP9 CBL CBLB CD19 CD28 CD79A CD79B CD80 CD86 CDKN1A CDKN1B CHUK CREB1 CUL1 DAPP1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FBXW11 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FYN GAB1 GRB2 GSK3A GSK3B HBEGF HRAS IGHD IGHM IGHV IGHV7-81 IGKC IGKV1-5 IGKV4-1 IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IKBKB IKBKG IRS1 IRS2 ITPR1 ITPR2 ITPR3 KIT KITLG KL KLB KRAS LCK LYN MALT1 MAP3K7 MAPKAP1 MDM2 MIR26A1 MIR26A2 MLST8 MOV10 MTOR NCK1 NFKB1 NFKBIA NFKBIB NFKBIE NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 ORAI1 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PTPN11 RASGRP1 RASGRP3 REL RELA RICTOR RPS27A RPS6KB2 SH3KBP1 SHC1 SKP1 SOS1 SRMS STIM1 SYK THEM4 TNRC6A TNRC6B TNRC6C TRAT1 TRIB3 TRPC1 TSC2 UBA52 UBB UBC VAV1 +Signalling by NGF Reactome Pathway AATF ABR ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADORA2A ADRBK1 AGO1 AGO2 AGO3 AGO4 AKAP13 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGAP4 ARHGDIA ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ATF1 BAD BCL2L11 BRAF BTC CALM1 CAMK4 CASP2 CASP3 CASP9 CD19 CD28 CD80 CD86 CDK1 CDKN1A CDKN1B CHUK CLTA CREB1 CRK CRKL DNAL4 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 ECT2 EGF EGFR ELK1 ERBB2 ERBB3 ERBB4 EREG FGD1 FGD2 FGD3 FGD4 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FURIN FYN GAB1 GRB2 GSK3A GSK3B HBEGF HDAC1 HDAC2 HDAC3 HRAS IKBKB IL6 IL6R IL6ST IRAK1 IRS1 IRS2 ITGB3BP ITPR1 ITPR2 ITPR3 ITSN1 JAK1 JAK2 KALRN KIDINS220 KIT KITLG KL KLB KRAS LCK LINGO1 MAG MAGED1 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPKAP1 MAPKAPK2 MAPKAPK3 MCF2 MCF2L MDM2 MEF2A MEF2C MIR26A1 MIR26A2 MLST8 MOV10 MTOR MYD88 NCSTN NET1 NFKB1 NFKBIA NGEF NGF NGFR NGFRAP1 NR4A1 NRAS NRG1 NRG2 NRG3 NRG4 NTRK1 NTRK2 OBSCN OMG PCSK5 PCSK6 PDE1A PDE1B PDE1C PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PHLPP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHG2 PLEKHG5 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRDM4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PRKCI PSEN2 PSENEN PTEN PTPN11 RAC1 RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RASGRF2 RELA RHOA RICTOR RIPK2 RIT1 RIT2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 RTN4 SH3GL2 SHC1 SHC2 SHC3 SMPD2 SORCS3 SOS1 SOS2 SQSTM1 SRC STAT3 THEM4 TIAM1 TIAM2 TNRC6A TNRC6B TNRC6C TRAF6 TRAT1 TRIB3 TRIO TSC2 TYK2 UBA52 UBB UBC VAV1 VAV2 VAV3 YWHAB YWHAE +Signalling to ERK5 Reactome Pathway MAP2K5 MAPK7 +Signalling to ERKs Reactome Pathway BRAF CDK1 CRK CRKL FRS2 GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 PLCG1 PTPN11 RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RIT1 RIT2 SHC1 SHC2 SHC3 SOS1 SRC TYK2 YWHAB +Signalling to RAS Reactome Pathway CDK1 GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 PTPN11 RAF1 RALA RALB RALGDS SHC1 SHC2 SHC3 SOS1 SRC TYK2 YWHAB +Signalling to STAT3 Reactome Pathway NGF NTRK1 STAT3 +Signalling to p38 via RIT and RIN Reactome Pathway BRAF CDK1 HRAS IL6 IL6R IL6ST JAK1 JAK2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 PTPN11 RAF1 RIT1 RIT2 TYK2 YWHAB +Small interfering RNA (siRNA) biogenesis Reactome Pathway AGO1 AGO2 AGO3 AGO4 DICER1 PRKRA TARBP2 TSN TSNAX +Smooth Muscle Contraction Reactome Pathway ACTA2 ACTG2 CALD1 CALM1 ITGA1 ITGB5 LMOD1 MYH11 MYL12B MYL6 MYL6B MYL9 MYLK PXN SORBS1 SORBS3 TLN1 TPM1 TPM2 TPM3 TPM4 VCL +Sodium-coupled phosphate cotransporters Reactome Pathway SLC20A1 SLC20A2 SLC34A1 SLC34A2 SLC34A3 +Sodium-coupled sulphate, di- and tri-carboxylate transporters Reactome Pathway SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 +Sodium/Calcium exchangers Reactome Pathway SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 +Sodium/Proton exchangers Reactome Pathway SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 +Sperm Motility And Taxes Reactome Pathway CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG HVCN1 KCNU1 +Sperm:Oocyte Membrane Binding Reactome Pathway CD9 IZUMO1 IZUMO2 IZUMO3 IZUMO4 +Sphingolipid de novo biosynthesis Reactome Pathway ACER1 ACER2 ACER3 CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 COL4A3BP CSNK1G2 DEGS1 DEGS2 KDSR OSBP PPAP2A PPAP2B PPAP2C PPM1L PRKD1 SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3 VAPA VAPB +Sphingolipid metabolism Reactome Pathway ACER1 ACER2 ACER3 ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C CERK CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 COL4A3BP CSNK1G2 CTSA DEGS1 DEGS2 ENPP7 GALC GBA GBA2 GBA3 GLA GLB1 GLB1L GM2A HEXA HEXB KDSR NEU1 NEU2 NEU3 NEU4 OSBP PPAP2A PPAP2B PPAP2C PPM1L PRKD1 PSAP SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3 STS SUMF1 SUMF2 UGCG VAPA VAPB +Spry regulation of FGF signaling Reactome Pathway BRAF CBL GRB2 MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC +Stabilization of p53 Reactome Pathway ATM MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RPS27A TP53 UBA52 UBB UBC +Steroid hormones Reactome Pathway AKR1B1 CGA CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 CYP24A1 CYP27B1 CYP2R1 FDX1 FDX1L FDXR GC HSD11B1 HSD17B1 HSD17B12 HSD17B3 HSD3B1 HSD3B2 LGMN LHB LRP2 POMC SRD5A1 SRD5A2 SRD5A3 STAR STARD4 STARD5 STARD6 +Sterols are 12-hydroxylated by CYP8B1 Reactome Pathway CYP8B1 PTGIS +Stimulation of the cell death response by PAK-2p34 Reactome Pathway CASP3 PAK2 +Stimuli-sensing channels Reactome Pathway ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 BEST1 BEST2 BEST3 BEST4 BSND CLCA1 CLCA2 CLCA3P CLCA4 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB CLIC2 FKBP1B MCOLN1 MCOLN2 MCOLN3 NALCN NEDD4L OSTM1 RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK2 SGK3 SLC17A3 SLC9B1 SLC9B2 SLC9C1 SLC9C2 SRI TPCN1 TPCN2 TRDN TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 TSC22D3 TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UNC79 UNC80 WNK1 WNK2 WNK3 WNK4 WWP1 +Striated Muscle Contraction Reactome Pathway ACTN2 ACTN3 DES DMD MYBPC1 MYBPC2 MYBPC3 MYH3 MYH6 MYH8 MYL1 MYL2 MYL3 MYL4 NEB TCAP TMOD1 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TNNT3 TPM1 TPM2 TPM3 TPM4 TTN VIM +Sulfide oxidation to sulfate Reactome Pathway ETHE1 SLC25A10 SQRDL SUOX TST +Sulfur amino acid metabolism Reactome Pathway ADI1 AHCY APIP BHMT CBS CDO1 CNDP2 CSAD CTH ENOPH1 ETHE1 GCLC GCLM GOT1 MAT1A MRI1 MTAP MTR MTRR SLC25A10 SQRDL SUOX TST +Switching of origins to a post-replicative state Reactome Pathway CCNA1 CCNA2 CDC6 CDK2 CDKN1A CDKN1B CDT1 FZR1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RPS27A UBA52 UBB UBC +Syndecan interactions Reactome Pathway ACTN1 CASK FGF2 ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 PRKCA SDC1 SDC2 SDC3 SDC4 TGFB1 THBS1 TNC TRAPPC4 VTN +Synthesis And Processing Of GAG, GAGPOL Polyproteins Reactome Pathway NMT2 RPS27A TSG101 UBA52 UBB UBC VPS28 VPS37A VPS37B VPS37C VPS37D gag +Synthesis and interconversion of nucleotide di- and triphosphates Reactome Pathway AK1 AK2 AK5 CMPK1 CTPS1 CTPS2 DTYMK GLRX GSR GUK1 NME1 NME2 NME4 RRM1 RRM2 RRM2B TXN TXNRD1 +Synthesis and processing of ENV and VPU Reactome Pathway FURIN env vpu +Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Reactome Pathway CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2U1 CYP4A11 CYP4F2 +Synthesis of 12-eicosatetraenoic acid derivatives Reactome Pathway ALOX12 ALOX12B ALOX15 GPX1 GPX2 GPX4 +Synthesis of 15-eicosatetraenoic acid derivatives Reactome Pathway ALOX15 ALOX15B GPX1 GPX2 GPX4 PTGS2 +Synthesis of 5-eicosatetraenoic acids Reactome Pathway ALOX5 ALOX5AP GPX1 GPX2 GPX4 LTC4S +Synthesis of CL Reactome Pathway CRLS1 +Synthesis of DNA Reactome Pathway APEX1 CCNA1 CCNA2 CDC45 CDC6 CDK2 CDKN1A CDKN1B CDT1 DNA2 FEN1 FZR1 GINS1 GINS2 GINS4 LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RB1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC +Synthesis of Dolichyl-phosphate Reactome Pathway DHDDS DOLK DOLPP1 MVD SRD5A3 +Synthesis of GDP-mannose Reactome Pathway GMPPA GMPPB MPI PMM1 PMM2 +Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Reactome Pathway ALOX12 +Synthesis of IP2, IP, and Ins in the cytosol Reactome Pathway IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5J ISYNA1 OCRL SYNJ1 +Synthesis of IP3 and IP4 in the cytosol Reactome Pathway CALM1 INPP5B INPP5D INPP5J INPPL1 ITPK1 ITPKA ITPKB ITPKC OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SYNJ1 +Synthesis of IPs in the ER lumen Reactome Pathway MINPP1 +Synthesis of IPs in the nucleus Reactome Pathway IP6K1 IP6K2 IPMK IPPK +Synthesis of Ketone Bodies Reactome Pathway ACAT1 BDH1 HMGCL HMGCS2 +Synthesis of Leukotrienes (LT) and Eoxins (EX) Reactome Pathway ABCC1 ALOX15 ALOX5 ALOX5AP CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 DPEP1 DPEP2 DPEP3 GGT1 GGT5 LTA4H LTC4S MAPKAPK2 PTGR1 +Synthesis of Lipoxins (LX) Reactome Pathway ALOX12 ALOX5 ALOX5AP HPGD LTC4S PTGR1 +Synthesis of PA Reactome Pathway AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 GNPAT GPAM GPAT2 GPD1 GPD1L LCLAT1 LPCAT1 LPCAT4 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4B PLA2G4D PLA2G5 PLD1 PLD2 +Synthesis of PC Reactome Pathway ACHE BCHE CEPT1 CHAT CHKA CHKB CHPT1 LPIN1 LPIN2 LPIN3 PCYT1A PCYT1B PEMT PHOSPHO1 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 +Synthesis of PE Reactome Pathway CEPT1 CHKA CHKB EPT1 ETNK1 ETNK2 LPIN1 LPIN2 LPIN3 PCYT2 PHOSPHO1 PISD +Synthesis of PG Reactome Pathway CDS2 PGS1 PLD1 PLD2 PLD3 PLD4 PLD6 PTPMT1 +Synthesis of PI Reactome Pathway CDIPT CDS1 +Synthesis of PIPs at the ER membrane Reactome Pathway PI4K2B PI4KA SACM1L +Synthesis of PIPs at the Golgi membrane Reactome Pathway ARF1 ARF3 FIG4 INPP5E OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2G PIK3C3 PIK3R4 PIKFYVE SACM1L TPTE TPTE2 VAC14 +Synthesis of PIPs at the early endosome membrane Reactome Pathway FIG4 INPP4A INPP4B MTM1 MTMR2 MTMR4 PI4K2A PI4K2B PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 +Synthesis of PIPs at the late endosome membrane Reactome Pathway FIG4 MTM1 MTMR2 MTMR4 MTMR7 PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 +Synthesis of PIPs at the plasma membrane Reactome Pathway INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 MTM1 MTMR1 MTMR14 MTMR3 MTMR6 PI4K2A PI4K2B PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PTEN SYNJ1 SYNJ2 +Synthesis of PS Reactome Pathway PTDSS1 PTDSS2 +Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Reactome Pathway AKR1C3 CBR1 CYP8B1 FAM213B HPGD HPGDS PTGDS PTGES PTGES3 PTGIS PTGR1 PTGS1 PTGS2 TBXAS1 +Synthesis of UDP-N-acetyl-glucosamine Reactome Pathway GFPT1 GFPT2 GNPNAT1 PGM3 UAP1 +Synthesis of bile acids and bile salts Reactome Pathway ABCB11 ACOT8 ACOX2 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR BAAT CH25H CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 NCOA1 NCOA2 NR1H4 PTGIS RXRA SCP2 SLC27A2 SLC27A5 +Synthesis of bile acids and bile salts via 24-hydroxycholesterol Reactome Pathway AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR CYP27A1 CYP39A1 CYP46A1 CYP8B1 HSD3B7 PTGIS SLC27A2 SLC27A5 +Synthesis of bile acids and bile salts via 27-hydroxycholesterol Reactome Pathway AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 CYP27A1 CYP7A1 CYP7B1 CYP8B1 HSD3B7 NCOA1 NCOA2 NR1H4 PTGIS RXRA +Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Reactome Pathway ABCB11 ACOT8 ACOX2 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR BAAT CYP27A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 NCOA1 NCOA2 NR1H4 PTGIS RXRA SCP2 SLC27A2 SLC27A5 +Synthesis of diphthamide-EEF2 Reactome Pathway DNAJC24 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 EEF2 +Synthesis of dolichyl-phosphate mannose Reactome Pathway DPM1 DPM2 DPM3 +Synthesis of dolichyl-phosphate-glucose Reactome Pathway ALG5 +Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Reactome Pathway CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 EPHX2 +Synthesis of glycosylphosphatidylinositol (GPI) Reactome Pathway DPM2 PIGA PIGB PIGC PIGF PIGG PIGH PIGL PIGM PIGN PIGO PIGP PIGQ PIGV PIGW PIGX +Synthesis of pyrophosphates in the cytosol Reactome Pathway IP6K1 IP6K3 IPPK ITPK1 NUDT10 NUDT11 NUDT3 NUDT4 PPIP5K1 PPIP5K2 +Synthesis of substrates in N-glycan biosythesis Reactome Pathway ALG5 CMAS CTSA DHDDS DOLK DOLPP1 DPM1 DPM2 DPM3 GFPT1 GFPT2 GLB1 GMPPA GMPPB GNE GNPNAT1 MPI MVD NANP NANS NEU1 NEU2 NEU3 NEU4 NPL PGM3 PMM1 PMM2 SLC17A5 SLC35A1 SRD5A3 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 UAP1 +Synthesis of very long-chain fatty acyl-CoAs Reactome Pathway ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 HSD17B12 HSD17B3 TECR TECRL +Synthesis, secretion, and deacylation of Ghrelin Reactome Pathway ACHE BCHE GCG GH1 GHRL IGF1 INS KLF4 LEP MBOAT4 PCSK1 PLA2G7 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome Pathway CDX2 CTNNB1 DPP4 FFAR1 FFAR4 GCG GNAT3 GNB3 GNG13 GPR119 GRP LEP PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 TCF7L2 +Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Reactome Pathway DPP4 FFAR1 GATA4 GIP GPR119 ISL1 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +T41 mutants of beta-catenin aren't phosphorylated Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +TAK1 activates NFkB by phosphorylation and activation of IKKs complex Reactome Pathway AGER APP CHUK DHX9 HMGB1 IKBKB IKBKG IRAK1 IRAK2 MAP3K7 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 RELA RIPK2 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TRAF6 +TCF dependent signaling in response to WNT Reactome Pathway AKT1 AKT2 AMER1 APC ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CAV1 CBY1 CCDC88C CDC73 CHD8 CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTNNB1 CTNNBIP1 CUL3 CXXC4 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD4 FZD5 FZD6 FZD8 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MEN1 MYC PIP5K1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RBBP5 RBX1 RNF146 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SFRP1 SFRP2 SMARCA4 SMURF2 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TNKS TNKS2 TRRAP UBA52 UBB UBC USP34 USP8 WIF1 WNT1 WNT3 WNT3A WNT4 WNT5A WNT8A WNT8B WNT9A XIAP XPO1 YWHAZ ZNRF3 +TCF7L2 mutants don't bind CTBP Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +TCR signaling Reactome Pathway BCL10 CARD11 CD247 CD3D CD3E CD3G CD4 CHUK CSK ENAH EVL FYB GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IKBKB IKBKG INPP5D ITK LAT LCK LCP2 MALT1 MAP3K7 NCK1 NFKB1 NFKBIA PAG1 PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKCQ PTEN PTPRC RELA RIPK2 TAB2 TCRA TCRB TRAC TRAF6 TRAT1 TRBC1 TRBV12-3 UBE2N UBE2V1 VASP WAS ZAP70 +TET1,2,3 and TDG demethylate DNA Reactome Pathway TDG TET1 TET2 TET3 +TGF-beta receptor signaling activates SMADs Reactome Pathway BAMBI CBL FKBP1A FURIN MTMR4 NEDD4L NEDD8 PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA52 UBB UBC UBE2M UCHL5 USP15 XPO1 ZFYVE9 +TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Reactome Pathway ARHGEF18 CGN F11R FKBP1A PARD3 PARD6A PRKCZ RHOA RPS27A SMURF1 TGFB1 TGFBR1 TGFBR2 UBA52 UBB UBC +TGFBR1 KD Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +TGFBR1 LBD Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +TGFBR2 Kinase Domain Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +TGFBR2 MSI Frameshift Mutants in Cancer Reactome Pathway ARHGEF18 BAMBI CBL CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB MEN1 MTMR4 MYC NCOR1 NCOR2 NEDD4L NEDD8 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TFDP2 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 UBE2M UCHL5 USP15 USP9X WWTR1 XPO1 ZFYVE9 +TNF signaling Reactome Pathway ADAM17 TNF TNFRSF1A +TRAF3-dependent IRF activation pathway Reactome Pathway CREBBP DDX58 EP300 IFIH1 IFNB1 IKBKE IRF3 IRF7 MAVS RNF135 SIKE1 TBK1 TRAF3 TRIM25 +TRAF6 Mediated Induction of proinflammatory cytokines Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TRAF6 TYK2 UBA52 UBB UBC +TRAF6 mediated IRF7 activation Reactome Pathway CREBBP DDX58 DHX36 EP300 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKE IRF1 IRF2 IRF3 IRF7 MAVS MYD88 RNF135 SIKE1 TANK TBK1 TRAF2 TRAF6 TRIM25 +TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Reactome Pathway DHX36 IRAK1 IRAK4 IRF7 MYD88 TLR7 TLR8 TLR9 TRAF6 UBE2N UBE2V1 +TRAF6 mediated NF-kB activation Reactome Pathway AGER APP CHUK DDX58 DHX9 HMGB1 IFIH1 IKBKB IKBKG MAP3K1 MAVS MYD88 NFKB1 NFKB2 NFKBIA NFKBIB RELA RNF135 S100A12 S100B SAA1 TRAF2 TRAF6 TRIM25 +TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR7 TLR8 TLR9 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 +TRAF6 mediated induction of TAK1 complex Reactome Pathway CD14 LY96 MAP3K7 RPS27A SARM1 TAB1 TAB2 TAB3 TICAM1 TICAM2 TLR3 TLR4 TRAF6 UBA52 UBB UBC +TRAIL signaling Reactome Pathway CASP10 CASP8 CFLAR FADD TNFRSF10A TNFRSF10B TNFSF10 +TRIF-mediated TLR3/TLR4 signaling Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 CASP8 CD14 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FOS HMGB1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRF3 IRF7 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TLR3 TLR4 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 +TRIF-mediated programmed cell death Reactome Pathway CASP8 CD14 FADD LY96 RIPK1 RIPK3 TICAM1 TICAM2 TLR3 TLR4 +TRKA activation by NGF Reactome Pathway NGF NTRK1 +TRP channels Reactome Pathway MCOLN1 MCOLN2 MCOLN3 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 +TWIK related potassium channel (TREK) Reactome Pathway KCNK10 KCNK2 KCNK4 +TWIK-related alkaline pH activated K+ channel (TALK) Reactome Pathway KCNK16 KCNK17 +TWIK-related spinal cord K+ channel (TRESK) Reactome Pathway KCNK18 +TWIK-releated acid-sensitive K+ channel (TASK) Reactome Pathway KCNK3 KCNK9 +Tachykinin receptors bind tachykinins Reactome Pathway TAC1 TAC3 TACR1 TACR2 TACR3 +Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Reactome Pathway KCNK1 KCNK6 KCNK7 +Tandem pore domain halothane-inhibited K+ channel (THIK) Reactome Pathway KCNK13 +Tandem pore domain potassium channels Reactome Pathway KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 +Tat-mediated HIV elongation arrest and recovery Reactome Pathway CCNT1 CDK9 CTDP1 ELL GTF2F1 GTF2F2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 tat +Tat-mediated elongation of the HIV-1 transcript Reactome Pathway CCNH CCNT1 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB2 TCEB3 tat +Telomere C-strand (Lagging Strand) Synthesis Reactome Pathway APEX1 DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +Telomere C-strand synthesis initiation Reactome Pathway POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 +Telomere Extension By Telomerase Reactome Pathway DKC1 NHP2 RUVBL1 RUVBL2 TERT WRAP53 +Telomere Maintenance Reactome Pathway ACD APEX1 DKC1 DNA2 FEN1 H2AFB1 H2AFX H2AFZ H2BFS HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 LIG1 NHP2 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POT1 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RUVBL1 RUVBL2 TERF1 TERF2 TERF2IP TERT TINF2 WRAP53 +Terminal pathway of complement Reactome Pathway C5 C6 C7 C8A C8B C8G C9 +Termination of O-glycan biosynthesis Reactome Pathway MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 +Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Reactome Pathway AKT1 CALM1 DHFR GCH1 GCHFR HSP90AA1 NOS3 PRKG2 PTS SPR +The AIM2 inflammasome Reactome Pathway AIM2 CASP1 PYCARD +The IPAF inflammasome Reactome Pathway CASP1 NLRC4 fliC fljB prgJ +The NLRP1 inflammasome Reactome Pathway BCL2 BCL2L1 NLRP1 +The NLRP3 inflammasome Reactome Pathway APP CASP1 HSP90AB1 MEFV NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD SUGT1 TXN TXNIP hly +The activation of arylsulfatases Reactome Pathway ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK STS SUMF1 SUMF2 +The canonical retinoid cycle in rods (twilight vision) Reactome Pathway ABCA4 DHRS9 HSD17B1 HSD17B6 LRAT MYO7A NAPEPLD RBP1 RBP3 RBP4 RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RHO RLBP1 RPE65 SDR9C7 STRA6 TTR +The citric acid (TCA) cycle and respiratory electron transport Reactome Pathway ACO2 ADHFE1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP5S BSG COX11 COX14 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CS CYC1 CYCS D2HGDH DLAT DLD DLST ETFA ETFB ETFDH FH IDH2 IDH3A IDH3B IDH3G L2HGDH LDHA LDHB LRPPRC MDH2 MPC1 MPC2 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2 MT-CO3 MT-CYB MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NNT OGDH PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PPARD RXRA SCO1 SCO2 SDHA SDHB SDHC SDHD SLC16A1 SLC16A3 SLC16A8 SUCLA2 SUCLG1 SUCLG2 SURF1 TACO1 UCP1 UCP2 UCP3 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ +The fatty acid cycling model Reactome Pathway UCP1 UCP2 UCP3 +The phototransduction cascade Reactome Pathway CALM1 CNGA1 CNGB1 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GRK1 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT1 NMT2 PDE6A PDE6B PDE6G PPEF1 PRKCA PRKCQ RCVRN RGS9 RGS9BP RHO SAG SLC24A1 +The proton buffering model Reactome Pathway UCP1 UCP2 UCP3 +The retinoid cycle in cones (daylight vision) Reactome Pathway DHRS3 OPN1LW OPN1MW OPN1SW RBP3 RLBP1 +The role of Nef in HIV-1 replication and disease pathogenesis Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD247 CD28 CD4 CD8B DOCK2 ELMO1 FYN HCK HLA-A LCK PACS1 PAK2 RAC1 nef +Thrombin signalling through proteinase activated receptors (PARs) Reactome Pathway ARRB1 ARRB2 F2 F2R F2RL2 F2RL3 GNA11 GNA12 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK1 MAPK3 SRC +Thromboxane signalling through TP receptor Reactome Pathway GNA11 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 TBXA2R +Thyroxine biosynthesis Reactome Pathway CGA DIO1 DIO2 DIO3 IYD SLC5A5 TPO TSHB +Tie2 Signaling Reactome Pathway ANGPT1 ANGPT2 ANGPT4 DOK2 GRB14 GRB2 GRB7 HRAS KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK +Tight junction interactions Reactome Pathway CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 F11R INADL MPP5 PARD3 PARD6A PARD6B PARD6G PRKCI +Tolerance by Mtb to nitric oxide produced by macrophages Reactome Pathway MT2748 Rv2238c adhE2 ahpC ggtA glbN msrA tpx trxA +Tolerance of reactive oxygen produced by macrophages Reactome Pathway ahpC katG secA1 secA2 secD secE secF secG secY sodB sodC +Toll Like Receptor 10 (TLR10) Cascade Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR10 TLR5 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 fliC +Toll Like Receptor 2 (TLR2) Cascade Reactome Pathway AGER APP ATF1 ATF2 BTK CD14 CD36 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TIRAP TLR1 TLR2 TLR4 TLR6 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 porB +Toll Like Receptor 3 (TLR3) Cascade Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 CASP8 CD14 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FADD FOS HMGB1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRF3 IRF7 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TLR3 TLR4 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 +Toll Like Receptor 4 (TLR4) Cascade Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 BTK CASP8 CD14 CD180 CD36 CDK1 CHUK CREB1 DHX9 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FADD FOS HMGB1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 ITGAM ITGB2 JAK1 JAK2 JUN LBP LY86 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR6 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 porB +Toll Like Receptor 5 (TLR5) Cascade Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR10 TLR5 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 fliC +Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX36 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 IRF7 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR7 TLR8 TLR9 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 +Toll Like Receptor 9 (TLR9) Cascade Reactome Pathway AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DHX36 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT EEA1 ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK4 IRF7 JAK1 JAK2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR7 TLR8 TLR9 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 ZFYVE20 +Toll Like Receptor TLR1:TLR2 Cascade Reactome Pathway AGER APP ATF1 ATF2 BTK CD14 CD36 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TIRAP TLR1 TLR2 TLR4 TLR6 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 porB +Toll Like Receptor TLR6:TLR2 Cascade Reactome Pathway AGER APP ATF1 ATF2 BTK CD14 CD36 CDK1 CHUK CREB1 DHX9 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JUN LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TIRAP TLR1 TLR2 TLR4 TLR6 TRAF6 TYK2 UBA52 UBB UBC UBE2N UBE2V1 porB +Toll-Like Receptors Cascades Reactome Pathway AGER APP ATF1 ATF2 BIRC2 BIRC3 BTK CASP8 CD14 CD180 CD36 CDK1 CHUK CNPY3 CREB1 CTSB CTSK CTSL CTSS CTSV DHX36 DHX9 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT EEA1 ELK1 FADD FOS HMGB1 HSP90B1 IKBKB IKBKE IKBKG IL6 IL6R IL6ST IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 ITGAM ITGB2 JAK1 JAK2 JUN LBP LGMN LY86 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 RELA RIPK1 RIPK2 RIPK3 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SARM1 SIGIRR SOCS1 TAB1 TAB2 TAB3 TANK TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TRAF3 TRAF6 TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 UNC93B1 ZFYVE20 fliC porB +Toxicity of botulinum toxin type A (BoNT/A) Reactome Pathway HA-33 SNAP25 SV2A SV2B SV2C botA ha17 ha70 ntnha +Toxicity of botulinum toxin type B (BoNT/B) Reactome Pathway HA-33 SYT1 SYT2 VAMP2 botB ha17 ha70 ntnha +Toxicity of botulinum toxin type C (BoNT/C) Reactome Pathway SNAP25 STX1A STX1B +Toxicity of botulinum toxin type D (BoNT/D) Reactome Pathway SV2A SV2B SV2C VAMP1 VAMP2 botD +Toxicity of botulinum toxin type E (BoNT/E) Reactome Pathway SNAP25 SV2A SV2B ntnha +Toxicity of botulinum toxin type F (BoNT/F) Reactome Pathway SV2A SV2B SV2C VAMP1 VAMP2 botF +Toxicity of botulinum toxin type G (BoNT/G) Reactome Pathway SYT1 VAMP1 VAMP2 botG +Toxicity of tetanus toxin (TeNT) Reactome Pathway VAMP2 tetX +Trafficking and processing of endosomal TLR Reactome Pathway CNPY3 CTSB CTSK CTSL CTSS CTSV HSP90B1 LGMN TLR3 TLR7 TLR8 TLR9 UNC93B1 +Trafficking of AMPA receptors Reactome Pathway AKAP5 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CACNG2 CACNG3 CACNG4 CACNG8 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG4 EPB41L1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 MDM2 MYO6 NSF PICK1 PRKCA PRKCB PRKCG +Trafficking of GluR2-containing AMPA receptors Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 NSF PICK1 PRKCA PRKCB PRKCG +Trafficking of dietary sterols Reactome Pathway ABCG5 ABCG8 NPC1L1 +Trafficking of myristoylated proteins to the cilium Reactome Pathway ARL3 CYS1 NPHP3 RP2 UNC119B +Transcription Reactome Pathway 28S rRNA ALYREF BDP1 BRF1 BRF2 CBX3 CCNH CCNT1 CCNT2 CD3EAP CDC40 CDK7 CDK9 CHD3 CHD4 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CRCP CSTF1 CSTF2 CSTF3 CTDP1 DHX38 EHMT2 ELL ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HDAC2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB KAT2A KAT2B LSM10 LSM11 MAGOH MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 MTERF1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE NFIA NFIB NFIC NFIX NUDT21 PABPN1 PAPOLA PCF11 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRMT POU2F1 PTRF RBBP4 RBBP7 RBM8A RNGTT RNMT RNPS1 RRN3 SLBP SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SSB SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1D TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 TFAM TFB2M TTF1 TWISTNB U2AF1 U2AF2 UBTF UPF3B ZNF143 ZNF473 ZNRD1 +Transcription from mitochondrial promoters Reactome Pathway MTERF1 POLRMT TFAM TFB2M +Transcription of the HIV genome Reactome Pathway CCNH CCNT1 CCNT2 CDK7 CDK9 CTDP1 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 NELFA NELFB NELFCD NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT RNMT SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF9 TAF9B TBP TCEA1 TCEB1 TCEB2 TCEB3 tat +Transcription-coupled NER (TC-NER) Reactome Pathway APEX1 CCNH CDK7 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 LIG1 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 TCEA1 XAB2 +Transcriptional activation of cell cycle inhibitor p21 Reactome Pathway CDKN1A TP53 +Transcriptional activation of mitochondrial biogenesis Reactome Pathway ALAS1 ATF2 ATP5B CALM1 CAMK4 CARM1 CHD9 CREB1 CREBBP CYCS ESRRA GABPA GABPB1 HCFC1 HDAC3 HELZ2 MED1 MEF2C MEF2D MTERF MTERF1 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRF1 PEO1 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPRC1 RXRA SIRT3 SMARCD3 SSBP1 TBL1X TBL1XR1 TFAM TFB1M TFB2M TGS1 +Transcriptional activation of p53 responsive genes Reactome Pathway CDKN1A TP53 +Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Reactome Pathway CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B E2F4 E2F5 HDAC1 JUNB MEN1 MYC NCOR1 NCOR2 NEDD4L PARP1 PPM1A RBL1 RNF111 RPS27A SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SP1 TFDP1 TFDP2 TGIF1 TGIF2 TRIM33 UBA52 UBB UBC UBE2D1 UBE2D3 USP9X WWTR1 +Transcriptional regulation by small RNAs Reactome Pathway AAAS AGO1 AGO2 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB IPO8 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP2 SEH1L TNRC6A TPR +Transcriptional regulation of pluripotent stem cells Reactome Pathway CDX2 DKK1 EOMES EPAS1 EPAS1 (HIF2A) EPHA1 FGF2 FOXD3 GATA6 GSC HHEX HIF3A KLF4 LIN28A NANOG NR5A1 NR6A1 PBX1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU5F1 POU5F1 (OCT4) PRDM14 SALL4 SMAD2 SMAD4 SOX2 STAT3 TDGF1 TSC22D1 ZIC3 ZSCAN10 +Transcriptional regulation of white adipocyte differentiation Reactome Pathway ADIPOQ ANGPTL4 CARM1 CCNC CCND3 CD36 CDK19 CDK4 CDK8 CEBPA CEBPB CEBPD CHD9 CREBBP EBF1 EGR2 EP300 FABP4 HDAC3 HELZ2 KLF4 KLF5 LEP LPL MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NFKB1 NR2F2 PCK1 PLIN1 PPARA PPARG PPARGC1A RELA RXRA SLC2A4 SMARCD3 SREBF1 SREBF2 TBL1X TBL1XR1 TGFB1 TGS1 TNF WNT1 WNT10B +Transfer of LPS from LBP carrier to CD14 Reactome Pathway CD14 LBP +Transferrin endocytosis and recycling Reactome Pathway ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H MCOLN1 STEAP2 STEAP3 TCIRG1 TF TFRC +Translation Reactome Pathway 7SL RNA (ENSG00000222619) 7SL RNA (ENSG00000222639) DDOST EEF1A1 EEF1A1P5 EEF1A2 EEF1B2 EEF1D EEF1G EEF2 EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5B ETF1 FAU GSPT2 PABPC1 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRPR SRPRB SSR1 SSR2 SSR3 SSR4 TRAM1 UBA52 +Translation initiation complex formation Reactome Pathway EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H FAU PABPC1 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA +Translesion synthesis by DNA polymerases bypassing lesion on DNA template Reactome Pathway MAD2L2 POLH REV1 REV3L +Translesion synthesis by HREV1 Reactome Pathway REV1 +Translesion synthesis by Pol eta Reactome Pathway POLH +Translesion synthesis by Pol zeta Reactome Pathway MAD2L2 REV3L +Translocation of GLUT4 to the plasma membrane Reactome Pathway AKT1 AKT2 ASPSCR1 C2CD5 CALM1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 KIF3A KIF3B KIFAP3 LNPEP MYH1 MYH13 MYH15 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYO1C MYO5A PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11A RAB13 RAB14 RAB4A RAB8A RAC1 RALA RALGAPA2 RALGAPB RHOQ SFN SLC2A4 SNAP23 STX4 STXBP3 TBC1D1 TBC1D4 VAMP2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +Translocation of ZAP-70 to Immunological synapse Reactome Pathway CD247 CD3D CD3E CD3G CD4 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK TCRA TCRB TRAC TRBC1 TRBV12-3 ZAP70 +Transmembrane transport of small molecules Reactome Pathway AAAS ABCA10 ABCA12 ABCA2 ABCA3 ABCA4 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB5 ABCB6 ABCB7 ABCB8 ABCC1 ABCC10 ABCC11 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 ABCD2 ABCD3 ABCD4 ABCG1 ABCG2 ABCG4 ABCG5 ABCG8 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ALB ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ANXA2 APOA1 APOB APOD APOF AQP1 AQP10 AQP11 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 ARHGEF9 ARL2 ARV1 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B AVP AVPR2 BEST1 BEST2 BEST3 BEST4 BSND CARM1 CERK CETP CFTR CHD9 CLCA1 CLCA2 CLCA3P CLCA4 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB CLIC2 COX11 COX14 COX16 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CP CRABP2 CREBBP CYBRD1 CYCS CYP7A1 CYP7B1 FABP6 FKBP1B FLVCR1 FTH1 FTL FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 G6PC G6PC2 G6PC3 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GCK GCKR GLRA1 GLRA2 GLRA3 GLRA4 GLRB GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HELZ2 HEPH HK1 HK2 HK3 HMOX1 HMOX2 HTR3A HTR3B HTR3C HTR3D HTR3E LCN1 LCN12 LCN15 LCN2 LCN9 LRPPRC MCOLN1 MCOLN2 MCOLN3 MED1 MIP MT-CO1 MT-CO2 MT-CO3 MYO5B NAGLT1 NALCN NCOA1 NCOA2 NCOA6 NEDD4L NR1H4 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 OSTM1 PDZD11 PEX19 PEX3 PLAT PLG PLN POM121 PPARA PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 RAE1 RAF1 RANBP2 RARA RARB RARG RHAG RHBG RHCG RPS27A RXRA RXRB RXRG RYR1 RYR2 RYR3 S100A10 SCNN1A SCNN1B SCNN1D SCNN1G SCO1 SCO2 SEH1L SGK1 SGK2 SGK3 SLC10A2 SLC10A6 SLC11A1 SLC11A2 SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 SLC14A1 SLC14A2 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A1 SLC16A10 SLC16A3 SLC16A7 SLC16A8 SLC17A1 SLC17A3 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC18A1 SLC18A2 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A6 SLC26A7 SLC26A9 SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC31A1 SLC32A1 SLC33A1 SLC34A1 SLC34A2 SLC34A3 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC36A1 SLC36A2 SLC37A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC3A1 SLC3A2 SLC40A1 SLC41A1 SLC41A2 SLC43A1 SLC43A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC46A1 SLC47A1 SLC47A2 SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9B1 SLC9B2 SLC9C1 SLC9C2 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SMARCD3 SRI STEAP2 STEAP3 SURF1 TACO1 TBCD TBL1X TBL1XR1 TCIRG1 TF TFRC TGS1 TPCN1 TPCN2 TPR TRDN TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 TSC22D3 TTYH1 TTYH2 TTYH3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 UBA52 UBB UBC UNC79 UNC80 WNK1 WNK2 WNK3 WNK4 WWP1 +Transmission across Chemical Synapses Reactome Pathway ABAT ACHE ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 ALDH2 ALDH5A1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BCHE BRAF BZRAP1 CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CHAT CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG COMT CPLX1 CREB1 DLG1 DLG3 DLG4 DNAJC5 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GAD1 GAD2 GLS GLS2 GLUL GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP1 GRIP2 HRAS HSPA8 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 MAOA MAPK1 MDM2 MYO6 NCALD NEFL NSF PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG RAB3A RAF1 RASGRF1 RASGRF2 RIMS1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC22A1 SLC22A2 SLC32A1 SLC38A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A3 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +Transmission across Electrical Synapses Reactome Pathway GJA10 GJC1 GJD2 PANX1 PANX2 +Transport and synthesis of PAPS Reactome Pathway PAPSS1 PAPSS2 SLC26A1 SLC26A2 SLC35B2 SLC35B3 +Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus Reactome Pathway HA M NA +Transport of Mature Transcript to Cytoplasm Reactome Pathway AAAS ALYREF CDC40 CPSF1 CPSF2 CPSF3 DHX38 EIF4E MAGOH NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 RBM8A RNPS1 SEH1L SLBP SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 TPR U2AF1 U2AF2 UPF3B +Transport of Mature mRNA Derived from an Intronless Transcript Reactome Pathway AAAS ALYREF CPSF1 CPSF2 CPSF3 EIF4E NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 SEH1L TPR +Transport of Mature mRNA derived from an Intron-Containing Transcript Reactome Pathway AAAS ALYREF CDC40 DHX38 EIF4E MAGOH NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 RBM8A RNPS1 SEH1L SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 TPR U2AF1 U2AF2 UPF3B +Transport of Mature mRNAs Derived from Intronless Transcripts Reactome Pathway AAAS ALYREF CPSF1 CPSF2 CPSF3 EIF4E NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 SEH1L SLBP TPR +Transport of Ribonucleoproteins into the Host Nucleus Reactome Pathway AAAS KPNA1 KPNB1 NP NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POM121 RAE1 RANBP2 SEH1L TPR +Transport of connexins along the secretory pathway Reactome Pathway GJA1 GJB1 GJB2 +Transport of connexons to the plasma membrane Reactome Pathway GJA1 GJB2 +Transport of fatty acids Reactome Pathway APOD LCN1 LCN12 LCN15 LCN9 SLC27A1 SLC27A4 SLC27A6 +Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Reactome Pathway F10 F2 F7 F9 GAS6 PROC PROS1 PROZ +Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Reactome Pathway CP HEPH NAGLT1 RHAG RHBG RHCG SLC10A6 SLC11A1 SLC11A2 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 SLC14A1 SLC14A2 SLC16A1 SLC16A3 SLC16A7 SLC16A8 SLC18A1 SLC18A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC31A1 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC40A1 SLC41A1 SLC41A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC47A1 SLC47A2 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A4 SLC5A7 SLC5A9 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +Transport of glycerol from adipocytes to the liver by Aquaporins Reactome Pathway AQP7 AQP9 +Transport of inorganic cations/anions and amino acids/oligopeptides Reactome Pathway SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A10 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A6 SLC26A7 SLC26A9 SLC32A1 SLC34A1 SLC34A2 SLC34A3 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A5 SLC5A8 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Reactome Pathway SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 +Transport of nucleotide sugars Reactome Pathway SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 +Transport of organic anions Reactome Pathway ALB AVP SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 +Transport of the SLBP Dependant Mature mRNA Reactome Pathway AAAS ALYREF EIF4E NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 SEH1L SLBP TPR +Transport of the SLBP independent Mature mRNA Reactome Pathway AAAS ALYREF EIF4E NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 SEH1L TPR +Transport of vitamins, nucleosides, and related molecules Reactome Pathway ALB APOD AVP LCN1 LCN12 LCN15 LCN9 PDZD11 SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC33A1 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC5A6 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 +Transport to the Golgi and subsequent modification Reactome Pathway B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 FUT8 LMAN1 MAN1A1 MAN1A2 MAN1C1 MAN2A1 MAN2A2 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 PREB SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A ST3GAL4 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +Triglyceride Biosynthesis Reactome Pathway ACACA ACLY ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 DGAT1 DGAT2 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 FASN GK GK2 GK3P GPAM GPAT2 GPD1 GPD1L HSD17B12 HSD17B3 LCLAT1 LPCAT1 LPCAT4 LPIN1 LPIN2 LPIN3 SLC25A1 TECR TECRL +Tristetraprolin (TTP) destabilizes mRNA Reactome Pathway DCP1A DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MAPKAPK2 TNPO1 XRN1 YWHAB ZFP36 +Tryptophan catabolism Reactome Pathway AADAT ACMSD AFMID CCBL1 CCBL2 HAAO IDO1 IDO2 KMO KYNU TDO2 +Type I hemidesmosome assembly Reactome Pathway CD151 COL17A1 DST ITGA6 ITGB4 LAMA3 LAMB3 LAMC2 PLEC +Type II Na+/Pi cotransporters Reactome Pathway SLC34A1 SLC34A2 SLC34A3 +Ubiquinol biosynthesis Reactome Pathway COQ2 COQ3 COQ5 COQ6 COQ7 PDSS1 PDSS2 +Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Reactome Pathway ATM CDC25A CHEK1 CHEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Ubiquitin-dependent degradation of Cyclin D Reactome Pathway CCND1 CDK4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Ubiquitin-dependent degradation of Cyclin D1 Reactome Pathway CCND1 CDK4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +Unblocking of NMDA receptor, glutamate binding and activation Reactome Pathway ACTN2 AKAP9 CAMK2A CAMK2B CAMK2D CAMK2G DLG4 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL +Uncoating of the HIV Virion Reactome Pathway PPIA gag gag-pol nef rev vif vpr vpu +Uncoating of the Influenza Virion Reactome Pathway HA M NA NP NS PA PB1 PB2 +Unfolded Protein Response (UPR) Reactome Pathway ACADVL ADD1 ARFGAP1 ASNS ATF3 ATF4 ATF6 ATP6V0D1 ATPV0D1 C19orf10 CALR CCL2 CTDSP2 CUL7 CXCL8 CXXC1 DCP2 DCTN1 DDIT3 DDX11 DIS3 DNAJB11 DNAJB9 DNAJC3 EDEM1 EIF2AK3 EIF2S1 ERN1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXTL3 FKBP14 FKBP14 gene GFPT1 GOSR2 GSK3A HDGF HERPUD1 HSP90B1 HSPA5 HYOU1 IGFBP1 IL8 KDELR3 KHSRP KLHDC3 LMNA MBTPS1 MBTPS2 NFYA NFYB NFYC PARN PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPR SRPRB SSR1 SULT1A3 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +Unwinding of DNA Reactome Pathway CDC45 GINS1 GINS2 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 +Uptake and actions of bacterial toxins Reactome Pathway ANTXR1 ANTXR2 CALM1 CD9 EEF2 FURIN HA-33 HBEGF HSP90AA1 HSP90AB1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 PDCD6IP SNAP25 STX1A STX1B SV2A SV2B SV2C SYT1 SYT2 TXNRD1 VAMP1 VAMP2 botA botB botD botF botG cya ha17 ha70 lef ntnha pagA tetX +Uptake and function of anthrax toxins Reactome Pathway ANTXR1 ANTXR2 CALM1 FURIN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 PDCD6IP cya lef pagA +Uptake and function of diphtheria toxin Reactome Pathway CD9 EEF2 HBEGF HSP90AA1 HSP90AB1 TXNRD1 +Urea cycle Reactome Pathway ARG1 ARG2 ASL ASS1 CPS1 NAGS OTC SLC25A15 SLC25A2 +Utilization of Ketone Bodies Reactome Pathway ACAT1 BDH1 OXCT1 +VEGF binds to VEGFR leading to receptor dimerization Reactome Pathway FIGF FLT1 FLT4 KDR PGF VEGFA VEGFB VEGFC +VEGF ligand-receptor interactions Reactome Pathway FIGF FLT1 FLT4 KDR PGF VEGFA VEGFB VEGFC +VEGFA-VEGFR2 Pathway Reactome Pathway ABI1 ABI2 AKT1 AKT2 AKT3 AXL BAIAP2 BCAR1 BRK1 CALM1 CAV1 CDC42 CDH5 CDK1 CRK CTNNA1 CTNNB1 CTNND1 CYBA CYBB CYFIP2 DOCK1 ELMO1 ELMO2 FYN HRAS HSP90AA1 HSPB1 IL6 IL6R IL6ST ITGAV ITGB3 ITPR1 ITPR2 ITPR3 JAK1 JAK2 JUP KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAP1 MAPKAPK2 MAPKAPK3 MLST8 MTOR NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NOS3 NRAS PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCZ PTK2 PTK2B PTPN11 PXN RAC1 RAF1 RASA1 RHOA RICTOR ROCK1 ROCK2 SH2D2A SHB SHC2 SPHK1 SRC THEM4 TRIB3 TYK2 VAV1 VAV2 VAV3 VEGFA WASF1 WASF2 WASF3 YWHAB +VEGFR2 mediated cell proliferation Reactome Pathway CALM1 CDK1 HRAS IL6 IL6R IL6ST ITPR1 ITPR2 ITPR3 JAK1 JAK2 KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PDPK1 PLCG1 PRKCA PRKCB PRKCD PRKCZ PTPN11 RAF1 RASA1 SPHK1 SRC TYK2 VEGFA YWHAB +VEGFR2 mediated vascular permeability Reactome Pathway AKT1 AKT2 AKT3 CALM1 CAV1 CDH5 CTNNA1 CTNNB1 CTNND1 HSP90AA1 JUP MAPKAP1 MLST8 MTOR NOS3 PAK1 PAK2 PAK3 PDPK1 RAC1 RICTOR THEM4 TRIB3 VAV1 VAV2 VAV3 +Vasopressin regulates renal water homeostasis via Aquaporins Reactome Pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP2 AQP3 AQP4 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 +Vasopressin-like receptors Reactome Pathway AVP AVPR1A AVPR1B AVPR2 OXT OXTR +Vif-mediated degradation of APOBEC3G Reactome Pathway APOBEC3G CUL5 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A TCEB1 TCEB2 UBA52 UBB UBC vif +Viral Messenger RNA Synthesis Reactome Pathway AAAS GTF2F1 GTF2F2 NP NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PA PB1 PB2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RANBP2 SEH1L TPR +Viral RNP Complexes in the Host Cell Nucleus Reactome Pathway HSPA1A M NP NS PA PB1 PB2 +Viral mRNA Translation Reactome Pathway DNAJC3 FAU GRSF1 HA M NA NP NS PA PB1 PB2 RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA UBA52 +Virus Assembly and Release Reactome Pathway CALR CANX HA M NA NP NS PA PB1 PB2 +Visual phototransduction Reactome Pathway ABCA4 AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE BCO1 BCO2 CALM1 CLPS CNGA1 CNGB1 DHRS3 DHRS9 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GRK1 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F HSD17B1 HSD17B6 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 METAP1 METAP2 MYO7A NAPEPLD NMT1 NMT2 OPN1LW OPN1MW OPN1SW PDE6A PDE6B PDE6G PLB1 PNLIP PPEF1 PRKCA PRKCQ RBP1 RBP2 RBP3 RBP4 RCVRN RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RGS9 RGS9BP RHO RLBP1 RPE65 SAG SDC1 SDC2 SDC3 SDC4 SDR9C7 SLC24A1 STRA6 TTR +Vitamin B1 (thiamin) metabolism Reactome Pathway SLC19A2 SLC19A3 THTPA TPK1 +Vitamin B2 (riboflavin) metabolism Reactome Pathway ACP5 ENPP1 FLAD1 RFK SLC52A3 +Vitamin B5 (pantothenate) metabolism Reactome Pathway AASDHPPT COASY FASN PANK1 PANK2 PANK3 PANK4 PDZD11 PPCDC PPCS SLC25A16 SLC5A6 +Vitamin C (ascorbate) metabolism Reactome Pathway CYB5A CYB5R3 GSTO1 GSTO2 SLC23A1 SLC23A2 SLC2A1 SLC2A3 +Vitamin D (calciferol) metabolism Reactome Pathway CUBN CYP24A1 CYP27B1 CYP2R1 GC LGMN LRP2 +Vitamins Reactome Pathway CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27B1 CYP2R1 +Vitamins B6 activation to pyridoxal phosphate Reactome Pathway AOX1 PDXK PNPO +Voltage gated Potassium channels Reactome Pathway KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 +Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Reactome Pathway SLC25A4 SLC25A5 SLC25A6 vpr +Vpr-mediated nuclear import of PICs Reactome Pathway AAAS BANF1 HMGA1 KPNA1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 POM121 PSIP1 RAE1 RANBP2 SEH1L TPR gag gag-pol rev vif vpr vpu +Vpu mediated degradation of CD4 Reactome Pathway BTRC CD4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A SKP1 UBA52 UBB UBC vpu +VxPx cargo-targeting to cilium Reactome Pathway ARF4 ASAP1 CNGA2 CNGA4 CNGB1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 PKD1 PKD2 RAB11A RAB11FIP3 RAB3IP RAB8A RHO +WNT ligand biogenesis and trafficking Reactome Pathway PORCN SNX3 TMED5 VPS26A VPS29 VPS35 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Reactome Pathway PORCN SNX3 TMED5 VPS26A VPS29 VPS35 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +WNT mediated activation of DVL Reactome Pathway CSNK1E CSNK2A1 CSNK2A2 CSNK2B DVL1 DVL2 DVL3 PIP5K1B +WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTB CLTC FZD2 FZD5 ROR1 ROR2 WNT5A +WNT5A-dependent internalization of FZD4 Reactome Pathway AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARRB2 CLTA CLTB CLTC DVL2 FZD4 PRKCA PRKCB PRKCG WNT5A +XAV939 inhibits tankyrase, stabilizing AXIN Reactome Pathway AKT1 AKT2 AMER1 APC ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CAV1 CBY1 CCDC88C CDC73 CHD8 CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTNNB1 CTNNBIP1 CUL3 CXXC4 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD4 FZD5 FZD6 FZD8 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MEN1 MYC PIP5K1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RBBP5 RBX1 RNF146 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SFRP1 SFRP2 SMARCA4 SMURF2 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TNKS TNKS2 TRRAP UBA52 UBB UBC USP34 USP8 WIF1 WNT1 WNT3 WNT3A WNT4 WNT5A WNT8A WNT8B WNT9A XIAP XPO1 YWHAZ ZNRF3 +XBP1(S) activates chaperone genes Reactome Pathway ACADVL ADD1 ARFGAP1 ATP6V0D1 ATPV0D1 C19orf10 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DNAJB11 DNAJB9 DNAJC3 EDEM1 EXTL3 FKBP14 FKBP14 gene GFPT1 GOSR2 GSK3A HDGF HYOU1 KDELR3 KLHDC3 LMNA PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPR SRPRB SSR1 SULT1A3 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +Xenobiotics Reactome Pathway CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2S1 CYP2W1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 +YAP1- and WWTR1 (TAZ)-stimulated gene expression Reactome Pathway CARM1 CHD9 CREBBP CTGF GATA4 HELZ2 HIPK1 HIPK2 KAT2B MED1 NCOA1 NCOA2 NCOA6 NKX2-5 NPPA PPARA RUNX2 RXRA SMARCD3 TBL1X TBL1XR1 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 TGS1 WWTR1 YAP1 +ZBP1(DAI) mediated induction of type I IFNs Reactome Pathway AGER APP CHUK DHX9 DTX4 HMGB1 IKBKB IKBKG IRF3 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 RELA RIPK1 RIPK3 S100A12 S100B SAA1 TBK1 TICAM1 TLR3 TMEM173 ZBP1 +Zinc efflux and compartmentalization by the SLC30 family Reactome Pathway SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 +Zinc influx into cells by the SLC39 gene family Reactome Pathway SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 +Zinc transporters Reactome Pathway SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 +activated TAK1 mediates p38 MAPK activation Reactome Pathway IKBKG IRAK1 IRAK2 MAP2K3 MAP2K6 MAP3K7 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TRAF6 +alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Reactome Pathway ABCD1 ACAA1 ACOT8 ACOX1 ACSL1 ELOVL2 ELOVL5 FADS1 FADS2 HSD17B4 SCP2 +alpha-linolenic acid (ALA) metabolism Reactome Pathway ABCD1 ACAA1 ACOT8 ACOX1 ACSL1 ELOVL2 ELOVL5 FADS1 FADS2 HSD17B4 SCP2 +beta-catenin independent WNT signaling Reactome Pathway AGO1 AGO2 AGO3 AGO4 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARRB2 AXIN2 CALM1 CAMK2A CLTA CLTB CLTC CTNNB1 DAAM1 DVL1 DVL2 DVL3 FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 GNAO1 GNAT2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR1 ITPR2 ITPR3 LEF1 MAP3K7 MIR92b MOV10 NFATC1 NLK PARD6A PDE6A PDE6B PDE6G PFN1 PLCB1 PLCB2 PLCB3 PPP3CA PPP3CB PPP3R1 PRICKLE1 PRKCA PRKCB PRKCG PRKG1 PRKG2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC1 RAC2 RAC3 RHOA ROR1 ROR2 RPS27A RYK SCRIB SMURF1 SMURF2 TCF7 TCF7L1 TCF7L2 TNRC6A TNRC6B TNRC6C UBA52 UBB UBC VANGL2 WNT1 WNT11 WNT4 WNT5A WNT5B +betaKlotho-mediated ligand binding Reactome Pathway FGF19 FGFR4 KLB +binding of TCF/LEF:CTNNB1 to target gene promoters Reactome Pathway AXIN2 CTNNB1 LEF1 MYC TCF7 TCF7L1 TCF7L2 +c-src mediated regulation of Cx43 function and closure of gap junctions Reactome Pathway GJA1 SRC TJP1 +cGMP effects Reactome Pathway ITPR1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE9A PRKG1 PRKG2 +cRNA Synthesis Reactome Pathway NP PA PB1 PB2 +deactivation of the beta-catenin transactivating complex Reactome Pathway AKT1 AKT2 APC ASH2L BCL9 BCL9L BTRC CBY1 CHD8 CTBP1 CTNNB1 CTNNBIP1 HDAC1 KMT2D LEF1 MEN1 PYGO1 PYGO2 RBBP5 RPS27A TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC XIAP XPO1 YWHAZ +degradation of AXIN Reactome Pathway AXIN1 AXIN2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RNF146 RPS27A SMURF2 TNKS TNKS2 UBA52 UBB UBC +degradation of DVL Reactome Pathway CUL3 DACT1 DVL1 DVL2 DVL3 HECW1 KLHL12 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A UBA52 UBB UBC +deletions in the AMER1 gene destabilize the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +disassembly of the destruction complex and recruitment of AXIN to the membrane Reactome Pathway AMER1 APC AXIN1 CAV1 CSNK1A1 CSNK1G2 CTNNB1 DVL1 DVL2 DVL3 FRAT1 FRAT2 FZD1 FZD2 FZD5 GSK3B LRP5 LRP6 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WNT1 WNT3A WNT8A WNT8B +eNOS activation Reactome Pathway AKT1 CALM1 CAV1 HSP90AA1 LYPLA1 NOS3 ZDHHC21 +eNOS activation and regulation Reactome Pathway AKT1 CALM1 CAV1 DHFR DNM2 GCH1 GCHFR HSP90AA1 LYPLA1 NOS3 NOSIP NOSTRIN PRKG2 PTS SPR WASL ZDHHC21 +formation of the beta-catenin:TCF transactivating complex Reactome Pathway ASH2L AXIN2 BCL9 BCL9L CDC73 CREBBP CTNNB1 EP300 H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KMT2D LEF1 LEO1 MEN1 MYC PYGO1 PYGO2 RBBP5 RUVBL1 SMARCA4 TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TRRAP +mRNA 3'-end processing Reactome Pathway ALYREF CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 MAGOH NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 U2AF1 U2AF2 UPF3B +mRNA Capping Reactome Pathway CCNH CDK7 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 MNAT1 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT RNMT SUPT5H +mRNA Editing Reactome Pathway A1CF ADAR ADARB1 APOBEC1 +mRNA Editing: A to I Conversion Reactome Pathway ADAR ADARB1 +mRNA Editing: C to U Conversion Reactome Pathway A1CF APOBEC1 +mRNA Splicing Reactome Pathway ALYREF BCAS2 CCAR1 CD2BP2 CDC40 CDC5L CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTNNBL1 CWC15 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 FUS GTF2F1 GTF2F2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 HSPA8 LSM2 MAGOH NCBP1 NCBP2 NHP2L1 NUDT21 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A PLRG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRPF19 PRPF4 PRPF6 PRPF8 PTBP1 RBM5 RBM8A RBMX RNPS1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 TXNL4A U2AF1 U2AF2 UPF3B YBX1 +mRNA Splicing - Major Pathway Reactome Pathway ALYREF BCAS2 CCAR1 CD2BP2 CDC40 CDC5L CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTNNBL1 CWC15 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 FUS GTF2F1 GTF2F2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 HSPA8 LSM2 MAGOH NCBP1 NCBP2 NHP2L1 NUDT21 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A PLRG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRPF19 PRPF4 PRPF6 PRPF8 PTBP1 RBM5 RBM8A RBMX RNPS1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 TXNL4A U2AF1 U2AF2 UPF3B YBX1 +mRNA Splicing - Minor Pathway Reactome Pathway DDX23 EFTUD2 GTF2F1 GTF2F2 LSM2 NCBP1 NCBP2 NHP2L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRPF6 PRPF8 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SNRNP200 SNRNP40 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRSF1 SRSF2 SRSF6 SRSF7 TXNL4A +mRNA decay by 3' to 5' exoribonuclease Reactome Pathway DCPS DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 +mRNA decay by 5' to 3' exoribonuclease Reactome Pathway DCP1A DCP1B DCP2 DDX6 EDC3 EDC4 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 PATL1 XRN1 +mTOR signalling Reactome Pathway AKT2 CAB39 CAB39L EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 MLST8 MTOR PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPS6 RPS6KB1 RPTOR STK11 STRADA STRADB TSC1 TSC2 +mTORC1-mediated signalling Reactome Pathway EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 MLST8 MTOR RHEB RPS6 RPS6KB1 RPTOR +misspliced GSK3beta mutants stabilize beta-catenin Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Reactome Pathway AKT1 AKT2 AMER1 APC ASH2L AXIN1 AXIN2 BCL9 BCL9L BTRC CAV1 CBY1 CCDC88C CDC73 CHD8 CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTNNB1 CTNNBIP1 CUL3 CXXC4 DACT1 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FRAT1 FRAT2 FZD1 FZD2 FZD4 FZD5 FZD6 FZD8 GSK3B H2AFB1 H2AFX H2AFZ H2BFS H3F3A HDAC1 HECW1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB HIST3H3 KAT5 KLHL12 KMT2D KREMEN1 KREMEN2 LEF1 LEO1 LGR4 LGR5 LGR6 LRP5 LRP6 MEN1 MYC PIP5K1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PYGO1 PYGO2 RBBP5 RBX1 RNF146 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 RUVBL1 RYK SFRP1 SFRP2 SMARCA4 SMURF2 SOST TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TNKS TNKS2 TRRAP UBA52 UBB UBC USP34 USP8 WIF1 WNT1 WNT3 WNT3A WNT4 WNT5A WNT8A WNT8B WNT9A XIAP XPO1 YWHAZ ZNRF3 +mitochondrial fatty acid beta-oxidation of saturated fatty acids Reactome Pathway ACADL ACADM ACADS ACADVL ECHS1 HADH HADHA HADHB +mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Reactome Pathway ACADL ACADM DECR1 ECI1 HADHA HADHB +negative regulation of TCF-dependent signaling by DVL-interacting proteins Reactome Pathway CCDC88C CXXC4 DVL1 DVL2 DVL3 +negative regulation of TCF-dependent signaling by WNT ligand antagonists Reactome Pathway DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 LRP6 SFRP1 SFRP2 SOST WIF1 WNT3A WNT4 WNT5A WNT9A +p130Cas linkage to MAPK signaling for integrins Reactome Pathway APBB1IP BCAR1 CRK FGA FGB FGG FN1 ITGA2B ITGB3 PTK2 RAP1A RAP1B SRC TLN1 VWF +p38MAPK events Reactome Pathway HRAS KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 NRAS RALA RALB RALGDS SRC +p53-Dependent G1 DNA Damage Response Reactome Pathway ATM CCNE1 CCNE2 CDK2 CDKN1A CDKN1B MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RPS27A TP53 UBA52 UBB UBC +p53-Dependent G1/S DNA damage checkpoint Reactome Pathway ATM CCNE1 CCNE2 CDK2 CDKN1A CDKN1B MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RPS27A TP53 UBA52 UBB UBC +p53-Independent DNA Damage Response Reactome Pathway ATM CDC25A CHEK1 CHEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +p53-Independent G1/S DNA damage checkpoint Reactome Pathway ATM CDC25A CHEK1 CHEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A UBA52 UBB UBC +p75 NTR receptor-mediated signalling Reactome Pathway AATF ABR ADAM17 AKAP13 APH1A APH1B ARHGAP4 ARHGDIA ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 CASP2 CASP3 ECT2 FGD1 FGD2 FGD3 FGD4 HDAC1 HDAC2 HDAC3 IKBKB IRAK1 ITGB3BP ITSN1 KALRN LINGO1 MAG MAGED1 MAPK8 MCF2 MCF2L MYD88 NCSTN NET1 NFKB1 NFKBIA NGEF NGF NGFR NGFRAP1 OBSCN OMG PLEKHG2 PLEKHG5 PRDM4 PRKCI PSEN2 PSENEN RAC1 RASGRF2 RELA RHOA RIPK2 RPS27A RTN4 SMPD2 SORCS3 SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 UBB UBC VAV1 VAV2 VAV3 YWHAE +p75NTR negatively regulates cell cycle via SC1 Reactome Pathway HDAC1 HDAC2 HDAC3 NGF NGFR PRDM4 +p75NTR recruits signalling complexes Reactome Pathway IKBKB IRAK1 MYD88 NGF NGFR PRKCI RIPK2 RPS27A SQSTM1 TRAF6 UBA52 UBB UBC +p75NTR regulates axonogenesis Reactome Pathway ARHGDIA ARHGEF1 LINGO1 MAG NGF NGFR OMG RHOA RTN4 +p75NTR signals via NF-kB Reactome Pathway IKBKB IRAK1 MYD88 NFKB1 NFKBIA NGF NGFR PRKCI RELA RIPK2 RPS27A SQSTM1 TRAF6 UBA52 UBB UBC +phospho-PLA2 pathway Reactome Pathway MAPK1 PLA2G4A +phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +regulation of FZD by ubiquitination Reactome Pathway FZD4 FZD5 FZD6 FZD8 LGR4 LGR5 LGR6 LRP5 LRP6 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 UBA52 UBB UBC USP8 WNT3A ZNRF3 +repression of WNT target genes Reactome Pathway AES AXIN2 CTBP1 CTBP2 CTNNB1 HDAC1 LEF1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 +snRNP Assembly Reactome Pathway AAAS CLNS1A DDX20 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 PHAX POM121 PRMT5 RAE1 RANBP2 SEH1L SMN1 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN TGS1 TPR WDR77 +t(4;14) translocations of FGFR3 Reactome Pathway FGFR3 +tRNA Aminoacylation Reactome Pathway AARS AARS2 AIMP1 AIMP2 CARS CARS2 DARS DARS2 EARS2 EEF1E1 EPRS FARS2 FARSA FARSB GARS HARS HARS2 IARS IARS2 KARS LARS LARS2 MARS MARS2 NARS NARS2 PARS2 PPA1 PPA2 QARS RARS RARS2 SARS SARS2 TARS TARS2 VARS VARS2 WARS WARS2 YARS YARS2 +trans-Golgi Network Vesicle Budding Reactome Pathway AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S6 CLINT1 CLTA CLTC CPD CTSZ DNAJC6 DNASE2 DNM2 DTNBP1 FTH1 FTL GAK GBF1 GNS HIP1R HSPA8 IGF2R M6PR NAPA NECAP1 OCRL PICALM PIK3C2A PUM1 RAB5C SH3D19 SH3GL2 SNAP23 SNAPIN SNX2 SNX5 SNX9 SORT1 STX4 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 +truncated APC mutants destabilize the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +truncations of AMER1 destabilize the destruction complex Reactome Pathway AES AMER1 APC AXIN1 AXIN2 BTRC CSNK1A1 CTBP1 CTBP2 CTNNB1 CUL1 FRAT1 FRAT2 GSK3B HDAC1 LEF1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RPS27A SKP1 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC +vRNA Synthesis Reactome Pathway NP PA PB1 PB2 +vRNP Assembly Reactome Pathway HSP90AA1 IPO5 NP PA PB1 PB2