gemini_inheritance: gemini_inheritance.xml annotate

annotate gemini_inheritance.xml @ 1:162a9d4a3bdc draft

"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 251c6024b4ff643a63e17fbfe2590998c2bae3a7"

author	iuc
date	Fri, 24 Jan 2020 17:33:03 -0500
parents	3123ce7acd0e
children	2c68e29c3527

rev	line source
0 3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	1 <tool id="gemini_inheritance" name="GEMINI inheritance pattern" version="@VERSION@">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	2 <description>based identification of candidate genes</description>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	3 <macros>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	4 <import>gemini_macros.xml</import>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	5 <xml name="name_X">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	6 <param name="X" type="text" value=""
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	7 label="Alias to use for X chromosome"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	8 help="The tool expects the X chromosome to be named 'X' or 'chrX'. If the reference genome used for variant calling had a different name for it, you will have to specify it here." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	9 </xml>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	10 </macros>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	11 <expand macro="requirements" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	12 <expand macro="stdio" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	13 <expand macro="version_command" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	14 <command>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	15 <![CDATA[
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	16 gemini ${inheritance.pattern_type}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	17
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	18 #for $cond in $inheritance.constraint:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	19 #set $filter = str($cond.filter).strip()
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	20 #if str($filter):
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	21 #if str($inheritance.pattern_type) == "comp_hets" and $cond.overwrite_default_filter:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	22 --gene-where '$filter'
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	23 #else:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	24 --filter '$filter'
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	25 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	26 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	27 #end for
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	28
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	29 #if str($inheritance.pattern_type) in ("comp_hets", "mendel_errors"):
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	30 ${inheritance.by_pattern_only}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	31 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	32
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	33 ${inheritance.lenient}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	34 ${inheritance.allow_unaffected}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	35
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	36 #if str($inheritance.pattern_type).startswith('x_linked_') and str($inheritance.X).strip():
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	37 -X "${inheritance.X}"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	38 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	39
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	40 #if int($family_wise.min_kindreds) > 0:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	41 --min-kindreds ${family_wise.min_kindreds}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	42 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	43
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	44 #if str($family_wise.families).strip():
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	45 #set $families = ','.join([f.strip() for f in $family_wise.families.split(',')])
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	46 --families "$families"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	47 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	48
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	49 #if int($family_wise.per_variant_selection.min_dp) > 0:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	50 -d ${family_wise.per_variant_selection.min_dp}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	51 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	52
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	53 #if int($family_wise.per_variant_selection.min_gq) > 0:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	54 --min-gq ${family_wise.per_variant_selection.min_gq}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	55 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	56
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	57 #if int($family_wise.per_variant_selection.max_pl) > -1:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	58 --gt-pl-max ${family_wise.per_variant_selection.max_pl}
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	59 #end if
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	60
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	61 #set $report = $oformat.report
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	62 @COLUMN_SELECT@
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	63
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	64 "${ infile }"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	65 > "${ outfile }"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	66 ]]>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	67 </command>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	68 <inputs>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	69 <expand macro="infile" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	70 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	71 <param name="pattern_type" type="select"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	72 label="Your assumption about the inheritance pattern of the phenotype of interest">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	73 <option value="autosomal_recessive">Autosomal recessive</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	74 <option value="autosomal_dominant">Autosomal dominant</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	75 <option value="x_linked_recessive">X-linked recessive</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	76 <option value="x_linked_dominant">X-linked dominant</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	77 <option value="de_novo">Autosomal de-novo</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	78 <option value="x_linked_de_novo">X-linked de-novo</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	79 <option value="comp_hets">Compound heterozygous</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	80 <option value="mendel_errors">Violation of mendelian laws (LOH, plausible and implausible de-novo, uniparental disomy)</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	81 </param>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	82 <when value="comp_hets">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	83 <expand macro="insert_constraint">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	84 <expand macro="overwritable_where_default" default_where="exonic and high-impact variants (SQL clause: is_exonic = 1 or impact_severity != 'LOW')" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	85 </expand>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	86 <param argument="--pattern-only" name="by_pattern_only" type="boolean" truevalue="--pattern-only" falsevalue="" checked="false"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	87 label="Ignore sample phenotypes during variant identification"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	88 help="When turned on, the identification of compound heterozygous variant pairs gets based on the family tree only, i.e., the tool looks for heterozygous allele pairs in any kid that weren't occuring together in the parents (see the tool help below for the exact criteria used to detect compound heterozygosity)." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	89 <expand macro="lenient" argument="--max-priority" truevalue="--max-priority 3"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	90 help="When turned on, runs the tool with --max-priority 3 instead of the default value 1. This leads to inclusion of more ambiguous cases of compound heterozygosity." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	91 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	92 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	93 <when value="mendel_errors">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	94 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	95 <param argument="--only-affected" name="by_pattern_only" type="boolean" truevalue="" falsevalue="--only-affected" checked="false"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	96 label="Ignore sample phenotypes during variant identification"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	97 help="When turned on, the identification of candidate variants gets based on the observed inheritance pattern only. The default is to report candidates only if there is evidence for them being phenotypically relevant, i.e., if they are observed in an affected sample." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	98 <expand macro="lenient" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	99 <param name="allow_unaffected" type="hidden" value="" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	100 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	101 <when value="autosomal_recessive">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	102 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	103 <expand macro="lenient" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	104 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	105 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	106 <when value="autosomal_dominant">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	107 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	108 <expand macro="lenient" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	109 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	110 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	111 <when value="x_linked_recessive">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	112 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	113 <param name="lenient" type="hidden" value="" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	114 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	115 <expand macro="name_X" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	116 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	117 <when value="x_linked_dominant">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	118 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	119 <param name="lenient" type="hidden" value="" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	120 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	121 <expand macro="name_X" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	122 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	123 <when value="de_novo">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	124 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	125 <expand macro="lenient" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	126 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	127 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	128 <when value="x_linked_de_novo">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	129 <expand macro="insert_constraint" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	130 <param name="lenient" type="hidden" value="" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	131 <expand macro="unaffected" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	132 <expand macro="name_X" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	133 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	134 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	135 <section name="family_wise" title="Family-wise criteria for variant selection" expanded="true">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	136 <expand macro="min_kindreds" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	137 <param argument="--families" name="families" type="text" value=""
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	138 label="List of families to restrict the analysis to (comma-separated)"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	139 help="Leave empty for an analysis including all families"/>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	140 <conditional name="per_variant_selection">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	141 <param name="enabled" type="select"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	142 label="Specify additional criteria to exclude families on a per-variant basis">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	143 <option value="no">No, analyze all variants from all included families</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	144 <option value="yes">Yes, filter variants within families</option>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	145 </param>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	146 <when value="no">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	147 <param name="min_dp" type="hidden" value="0" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	148 <param name="min_gq" type="hidden" value="0" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	149 <param name="max_pl" type="hidden" value="-1" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	150 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	151 <when value="yes">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	152 <param argument="-d" name="min_dp" type="integer" value="0" min="0"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	153 label="Per-variant DP threshold for including a family"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	154 help="All samples from a family must have a sequencing depth of at least this value at a given variant site in order for the family to be included in the analysis of this particular variant. default: 0 (do not apply this filter)" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	155 <param argument="--min-gq" name="min_gq" type="integer" value="0" min="0"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	156 label="per-variant GQ threshold for including a family"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	157 help="The genotypes of all samples from a family must be called with at least this quality at a given variant site in order for the family to be included in the analysis of this particular variant. default: 0 (do not apply this filter)">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	158 </param>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	159 <param argument="--gt-pl-max" name="max_pl" type="integer" value="-1" min="-1"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	160 label="per-variant PL threshold for including a family"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	161 help="The genotypes at a given variant site of all samples from a family must not have a higher (phred-scaled) likelihood to be wrong than this value in order for the family to be included in the analysis of this particular variant. default: -1 (do not apply this filter); if used the GEMINI documentation suggests 10 as a reasonable value" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	162 </when>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	163 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	164 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	165 <section name="oformat" title="Output - included information" expanded="true">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	166 <expand macro="column_filter" help="The tool reports key information about the inheritance pattern detection for each candidate variant found. It can precede each such row with additional columns, listing information about the variant taken from the variants table of the GEMINI database. Here, you can control which subset of the variants table columns should be added to the output."/>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	167 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	168 </inputs>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	169 <outputs>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	170 <data name="outfile" format="tabular"
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	171 label="GEMINI ${inheritance.pattern_type} pattern on ${on_string}" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	172 </outputs>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	173 <tests>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	174 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	175 <param name="infile" value="gemini_auto_dom_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	176 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	177 <param name="pattern_type" value="autosomal_dominant" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	178 <param name="lenient" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	179 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	180 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	181 <param name="report_selector" value="minimal" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	182 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	183 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	184 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	185 <has_line_matching expression="variant_id gene .*" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	186 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	187 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	188 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	189 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	190 <param name="infile" value="gemini_auto_dom_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	191 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	192 <param name="pattern_type" value="autosomal_dominant" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	193 <param name="lenient" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	194 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	195 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	196 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	197 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	198 <param name="columns" value="gene,chrom,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	199 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	200 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	201 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	202 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	203 <has_line_matching expression="gene chrom impact.*" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	204 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	205 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	206 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	207 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	208 <param name="infile" value="gemini_auto_dom_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	209 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	210 <param name="pattern_type" value="autosomal_dominant" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	211 <param name="lenient" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	212 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	213 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	214 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	215 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	216 <!-- test with empty multiselect list and columns specified
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	217 via text field instead -->
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	218 <param name="extra_cols" value="gene,chrom,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	219 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	220 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	221 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	222 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	223 <has_line_matching expression="gene chrom impact.*" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	224 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	225 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	226 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	227 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	228 <param name="infile" value="gemini_auto_rec_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	229 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	230 <param name="pattern_type" value="autosomal_recessive" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	231 <param name="lenient" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	232 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	233 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	234 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	235 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	236 <param name="columns" value="gene,chrom,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	237 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	238 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	239 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	240 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	241 <has_line_matching expression="gene chrom impact.*" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	242 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	243 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	244 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	245 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	246 <param name="infile" value="gemini_de_novo_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	247 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	248 <param name="pattern_type" value="de_novo" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	249 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	250 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	251 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	252 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	253 <param name="columns" value="gene,ref,alt,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	254 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	255 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	256 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	257 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	258 <has_line_matching expression="gene ref alt impact.*" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	259 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	260 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	261 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	262 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	263 <param name="infile" value="gemini_comphets_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	264 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	265 <param name="pattern_type" value="comp_hets" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	266 <param name="lenient" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	267 <param name="allow_unaffected" value="true" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	268 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	269 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	270 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	271 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	272 <param name="columns" value="chrom,start,end,ref,alt,gene,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	273 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	274 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	275 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	276 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	277 <has_line_matching expression="chrom start end .gene." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	278 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	279 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	280 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	281 <test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	282 <param name="infile" value="gemini_de_novo_input.db" ftype="gemini.sqlite" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	283 <conditional name="inheritance">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	284 <param name="pattern_type" value="mendel_errors" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	285 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	286 <section name="oformat">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	287 <conditional name="report">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	288 <param name="report_selector" value="custom" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	289 <param name="columns" value="gene,ref,alt,impact" />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	290 </conditional>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	291 </section>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	292 <output name="outfile">
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	293 <assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	294 <has_line_matching expression="gene ref alt impact .violation." />
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	295 </assert_contents>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	296 </output>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	297 </test>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	298 </tests>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	299 <help>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	300 <![CDATA[
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	301
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	302 What it does
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	303
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	304 Assuming you have defined the familial relationships between samples when
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	305 loading your VCF into GEMINI, you can use this tool to identify candidate genes
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	306 and variants that explain the inheritance pattern of a phenotype of interest.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	307
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	308 Inheritance pattern detection rules
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	309
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	310 Autosomal recessive
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	311
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	312 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	313
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	314 - all affected must be hom_alt
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	315 - [affected] no unaffected can be hom_alt (can be unknown)
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	316 - [default] if parents exist they must be unaffected and het for all affected kids
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	317 - [default] if there are no affecteds that have a parent, a warning is issued.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	318
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	319 If ``--lenient`` is specified, the 2 criteria prefixed with “[default]” are not
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	320 applied.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	321
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	322 If ``--allow-unaffected`` is specified, the criterion prefixed with
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	323 “[affected]” is not enforced.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	324
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	325 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	326
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	327 Autosomal dominant
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	328
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	329 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	330
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	331 - All affecteds must be het
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	332 - [affected] No unaffected can be het or homalt (can be unknown)
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	333 - de_novo mutations are not auto_dom (at least not in the first generation)
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	334 - At least 1 affected must have 1 affected parent (or have no parents).
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	335 - If no affected has a parent, a warning is issued.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	336 - [default] All affecteds must have parents with known phenotype.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	337 - [default] All affected kids must have at least 1 affected parent
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	338
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	339 If ``--lenient`` is specified, the criteria prefixed with “[default]” are not
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	340 enforced.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	341
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	342 If ``--allow-unaffected`` is specified, the criterion prefixed with
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	343 “[affected]” is not enforced.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	344
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	345 Note that, for autosomal dominant, ``--lenient`` allows singleton affecteds to
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	346 be used to meet the ``--min-kindreds`` requirement if they are HET.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	347
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	348 If there is incomplete penetrance in the kindred (unaffected obligate carriers),
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	349 these individuals currently must be coded as having unknown phenotype or as
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	350 being affected.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	351
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	352 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	353
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	354 X-linked recessive
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	355
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	356 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	357
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	358 - Affected females must be HOM_ALT
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	359 - Unaffected females are HET or HOM_REF
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	360 - Affected males are not HOM_REF
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	361 - Unaffected males are HOM_REF
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	362
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	363 Note: Pseudo-autosomal regions are not accounted for by the tool.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	364
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	365 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	366
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	367 X-linked dominant
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	368
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	369 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	370
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	371 - Affected males are HET or HOM_ALT
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	372 - Affected females must be HET
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	373 - Unaffecteds must be HOM_REF
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	374 - girls of affected dad must be affected
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	375 - boys of affected dad must be unaffected
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	376 - mothers of affected males must be het (and affected)
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	377 - at least 1 parent of affected females must be het (and affected).
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	378
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	379 Note: Pseudo-autosomal regions are not accounted for by the tool.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	380
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	381 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	382
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	383 De-novo mutations
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	384
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	385 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	386
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	387 - all affected must be het
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	388 - [affected] all unaffected must be homref or homalt
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	389 - at least 1 affected kid must have unaffected parents
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	390 - [default] if an affected has affected parents, it’s not de_novo
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	391 - [default] all affected kids must have unaffected (or no) parents
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	392 - [default] warning if none of the affected samples have parents.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	393
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	394 The last 3 items, prefixed with [default] can be turned off with ``--lenient``.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	395
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	396 If ``--allow-unaffected`` is specified, then the criterion prefixed [affected]
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	397 is not enforced.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	398
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	399 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	400
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	401 X-linked de-novo mutations
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	402
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	403 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	404
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	405 - affected female child must be het
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	406 - affected male child must be hom_alt (or het)
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	407 - parents should be unaffected and hom_ref
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	408
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	409 Note: Pseudo-autosomal regions are not accounted for by the tool.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	410
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	411 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	412
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	413 Compound heterozygosity
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	414
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	415 Unlike canonical recessive sites where the same recessive allele is inherited
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	416 from both parents at the same site in the gene, compound heterozygosity
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	417 occurs when the individual’s phenotype is caused by two heterozygous recessive
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	418 alleles at different sites in a particular gene.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	419
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	420 To detect compound heterozygosity, the tool looks for two heterozygous variants
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	421 impacting the same gene at different loci. The complicating factor is that this
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	422 is a case of recessive inheritance and as such, we must also require that the
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	423 consequential alleles at each heterozygous site were inherited on different
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	424 chromosomes (one from each parent). Hence, where possible, the tool will phase
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	425 by transmission.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	426
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	427 Criteria (default):
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	428
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	429 - All affected individuals must be heterozygous at both sites.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	430 - No unaffected can be homozygous alterate at either site.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	431 - Neither parent of an affected sample can be homozygous reference at both
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	432 sites.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	433 - If any unphased-unaffected is het at both sites, the site will be given lower
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	434 priority.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	435 - No phased-unaffected can be heterozygous at both sites.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	436
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	437 a. ``--allow-unaffected`` keeps sites where a phased unaffected shares the
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	438 het-pair
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	439 b. unphased, unaffected that share the het pair are counted and reported for
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	440 each candidate pair.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	441 - Candidates where an affected from the same family does NOT share the same het
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	442 pair are removed.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	443 - Sites are automatically phased by transmission when parents are present in
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	444 order to remove false positive candidates.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	445
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	446 If data from one or both parents are unavailable and the child’s data was not
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	447 phased prior to loading into GEMINI, all comp_het variant pairs will
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	448 automatically be given at most priority == 2. If there’s only a single parent
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	449 and both the parent and the affected are HET at both sites, the candidate
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	450 will have priority 3.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	451
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	452 Criteria (``--pattern-only``):
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	453
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	454 - Kid must be HET at both sites.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	455 - Kid must have alts on different chromosomes.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	456 - Neither parent can be HOM_ALT at either site.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	457 - If either parent is phased at both sites and matches the kid, it’s excluded.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	458 - When the above criteria are met, and both parents and kid are phased or
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	459 parents are HET at different sites, the priority is 1.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	460 - If either parent is HET at both sites, priority is reduced.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	461 - If both parents are not phased, the priority is 2.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	462 - For every parent that’s a het at both sites, the priority is incremented by 1.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	463 - The priority in a family is the minimum found among all kids.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	464
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	465 ----
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	466
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	467 Violation of Mendelian laws
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	468
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	469 The tool can be used to detect the following kinds of non-Mendelian patterns:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	470
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	471 - loss of heterozygosity (LOH) events
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	472 - de-novo mutations
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	473 - implausible de-novo mutations
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	474 - potential cases of uniparental disomy
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	475
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	476 Criteria:
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	477
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	478 - LOH: child and one parent are opposite homozygotes; other parent is HET
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	479 - plausible de novo: kid is het. parents are same homozygotes
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	480 - implausible de novo: kid is homozygote. parents are same homozygotes and opposite to kid.
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	481 - uniparental disomy: parents are opposite homozygotes; kid is homozygote
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	482
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	483 ]]>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	484 </help>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	485 <expand macro="citations"/>
3123ce7acd0e planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 62ed732cba355e695181924a8ed4cce49ca21c59 iuc parents: diff changeset	486 </tool>

Mercurial > repos > iuc > gemini_inheritance

annotate gemini_inheritance.xml @ 1:162a9d4a3bdc draft