# HG changeset patch
# User iuc
# Date 1615898322 0
# Node ID d2590ecc4189722dc81ed7f22ec17991d4e02862

"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hamronization commit 17562209ea2b5b8b28f229a5c305e468b04be58e"

diff -r 000000000000 -r d2590ecc4189 hamronize_tool.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/hamronize_tool.xml	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,200 @@
+<tool id="hamronize_tool" name="hamronize" version="@VERSION@+galaxy0">
+    <description> parse multiple Antimicrobial Resistance Analysis Reports into a common data structure</description>
+    <macros>
+        <import>macros.xml</import>
+    </macros>
+
+    <expand macro="requirements" />
+    <expand macro="version_command" />
+
+    <command detect_errors="exit_code"><![CDATA[
+        #set $extra_2_params = str("ariba,srax,csstar,groot").split(",")
+        #set $extra_1_param = $extra_2_params + str("amrfinderplus,rgi,resfinder4,deeparg,kmerresistance,srst2,amrplusplus,resfarms").split(",")
+        
+        hamronize 
+        ${select_tool.tool}
+        --analysis_software_version '${analysis_software_version}'
+        --reference_database_version '${reference_database_version}'
+        --format ${output_format}
+        #if $output_format == "tsv" 
+            --output hamronized.tsv
+        #else
+            --output hamronized.json
+        #end if 
+        
+        #if $select_tool.tool in $extra_1_param
+            --input_file_name $select_tool.input_file_name
+        #end if
+        
+        #if $select_tool.tool in $extra_2_params
+            --reference_database_id $select_tool.reference_database_id
+        #end if
+        
+        $report
+    ]]>    </command>
+
+    <inputs>
+        <param name="report" type="data" format="txt,tabular,tsv" label="Report file"/>
+        <conditional name="select_tool">
+            <param name="tool" type="select" label="Tool">
+                <option value="abricate" selected="true">abricate</option>
+                <option value="amrfinderplus">amrfinderplus</option>
+                <option value="ariba">ariba</option>
+                <option value="rgi">rgi</option>
+                <option value="resfinder">resfinder</option>
+                <option value="resfinder4">resfinder4</option>
+                <option value="srax">srax</option>
+                <option value="deeparg">deeparg</option>
+                <option value="kmerresistance">kmerresistance</option>
+                <option value="srst2">srst2</option>
+                <option value="staramr">staramr</option>
+                <option value="csstar">csstar</option>
+                <option value="amrplusplus">amrplusplus</option>
+                <option value="resfams">resfams</option>
+                <option value="groot">groot</option>
+            </param>
+            <when value="abricate" />
+            <when value="resfinder" />
+            <when value="staramr" />
+            <when value="amrfinderplus">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="ariba">
+                <expand macro="input_file_name"/>
+                <expand macro="reference_database_id"/>
+            </when>
+
+            <when value="rgi">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="resfinder4">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="srax">
+                <expand macro="input_file_name"/>
+                <expand macro="reference_database_id"/>
+            </when>
+
+            <when value="deeparg">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="kmerresistance">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="srst2">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="csstar">
+                <expand macro="input_file_name"/>
+                <expand macro="reference_database_id"/>
+            </when>
+
+            <when value="amrplusplus">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="resfams">
+                <expand macro="input_file_name"/>
+            </when>
+
+            <when value="groot">
+                <expand macro="input_file_name"/>
+                <expand macro="reference_database_id"/>
+            </when>
+        </conditional>
+        <param name="output_format" type="select" label="Output format" multiple="false" display="radio">
+            <option value="tsv" selected="True">tsv</option>
+            <option value="json">json</option>
+        </param>
+        <param name="analysis_software_version" type="text" label="Analysis software version"></param>
+        <param name="reference_database_version" type="text" label="Reference database version"></param>
+    </inputs>
+
+    <outputs>
+        <data format="tsv" name="output_tsv" label="${tool.name} on ${on_string}: Output" from_work_dir="hamronized.tsv">
+            <filter>output_format == "tsv"</filter>
+        </data>
+        <data format="json" name="output_json" label="${tool.name} on ${on_string}: Output" from_work_dir="hamronized.json">
+            <filter>output_format == "json"</filter>
+        </data>
+    </outputs>
+    <tests>
+        <!-- abricate -->
+        <test expect_num_outputs="1">
+            <param name="report" value="abricate/report.tsv" ftype="tsv" />
+            <param name="tool" value="abricate" />
+            <param name="output_format" value="tsv" />
+            <param name="reference_database_version" value="db_v_1" />
+            <param name="analysis_software_version" value="tool_v_1" />
+            <output name="output_tsv" ftype="tsv" file="hamronized_abricate.tsv" />
+        </test>
+        <test expect_num_outputs="1">
+            <param name="report" value="abricate/report.tsv" ftype="tsv" />
+            <param name="tool" value="abricate" />
+            <param name="output_format" value="json" />
+            <param name="reference_database_version" value="db_v_1" />
+            <param name="analysis_software_version" value="tool_v_1" />
+            <output name="output_json" ftype="json" file="hamronized_abricate.json" />
+        </test>
+        <!-- ariba -->
+        <test expect_num_outputs="1">
+            <param name="report" value="ariba/report.tsv" ftype="tsv" />
+            <param name="tool" value="ariba" />
+            <param name="output_format" value="tsv" />
+            <param name="reference_database_version" value="db_v_1" />
+            <param name="analysis_software_version" value="ariba_v1" />
+            <param name="input_file_name" value="ariba_report" />
+            <param name="reference_database_id" value="dbname" />
+            <output name="output_tsv" ftype="tsv" file="hamronized_ariba.tsv" />
+        </test>
+        <!-- rgi -->
+        <test expect_num_outputs="1">
+            <param name="report" value="rgi/rgi.txt" ftype="txt" />
+            <param name="tool" value="rgi" />
+            <param name="output_format" value="tsv" />
+            <param name="reference_database_version" value="card_v1" />
+            <param name="analysis_software_version" value="rgi_v1" />
+            <param name="input_file_name" value="rgi_report" />
+            <output name="output_tsv" ftype="tsv" file="hamronized_rgi.tsv" />
+        </test>
+    </tests>
+    <help><![CDATA[
+    **What it does**
+    Hamronize parse multiple Antimicrobial Resistance Analysis Reports into a common data structure
+
+    **Inputs**
+    
+    ::
+
+        Tools with hAMRonizable reports:
+        {abricate,amrfinderplus,ariba,rgi,resfinder,resfinder4,srax,deeparg,kmerresistance,srst2,staramr,csstar,amrplusplus,resfams,groot}
+        abricate            hAMRonize abricate's output report i.e., OUTPUT.tsv
+        amrfinderplus       hAMRonize amrfinderplus's output report i.e., OUTPUT.tsv
+        ariba               hAMRonize ariba's output report i.e., OUTDIR/OUTPUT.tsv
+        rgi                 hAMRonize rgi's output report i.e., OUTPUT.txt or OUTPUT_bwtoutput.gene_mapping_data.txt
+        resfinder           hAMRonize resfinder's output report i.e., data_resfinder.json
+        resfinder4          hAMRonize resfinder4's tabular output report i.e., ResFinder_results_tab.txt
+        srax                hAMRonize srax's output report i.e., sraX_detected_ARGs.tsv
+        deeparg             hAMRonize deeparg's output report i.e., OUTDIR/OUTPUT.mapping.ARG
+        kmerresistance      hAMRonize kmerresistance's output report i.e., OUTPUT.KmerRes
+        srst2               hAMRonize srst2's output report i.e., OUTPUT_srst2_report.tsv
+        staramr             hAMRonize staramr's output report i.e., resfinder.tsv
+        csstar              hAMRonize csstar's output report i.e., OUTPUT.tsv
+        amrplusplus         hAMRonize amrplusplus's output report i.e., gene.tsv
+        resfams             hAMRonize resfams's output report i.e., resfams.tblout
+        groot               hAMRonize groot's output report i.e., OUTPUT.tsv (from `groot report`)
+    
+
+
+    ::
+    
+    More: https://github.com/pha4ge/hAMRonization/#usage
+
+    ]]>    </help>
+</tool>
diff -r 000000000000 -r d2590ecc4189 macros.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/macros.xml	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,29 @@
+<macros>
+    <token name="@VERSION@">1.0.3</token>
+    
+    <xml name="requirements">
+        <requirements>
+            <requirement type="package" version="@VERSION@">hamronization</requirement>
+        </requirements>
+    </xml>
+    
+    <xml name="input_file_name">
+        <param name="input_file_name" type="text" label="Input file name" help="Sample name which was scanned with the tool"></param>
+    </xml>
+    
+    <xml name="reference_database_id">
+        <param name="reference_database_id" type="text" label="Reference database ID" help="String containing the reference_database_id of this tool"></param>
+    </xml>
+
+    <xml name="reference_database_version">
+        <param name="reference_database_version" type="text" label="Reference database version"></param>
+    </xml>
+
+    <xml name="analysis_software_version">
+        <param name="analysis_software_version" type="text" label="Analysis software version"></param>
+    </xml>
+    
+    <xml name="version_command">
+        <version_command>hamronize --version</version_command>
+    </xml>
+</macros>
\ No newline at end of file
diff -r 000000000000 -r d2590ecc4189 test-data/abricate/report.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/abricate/report.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,8 @@
+#FILE	SEQUENCE	START	END	STRAND	GENE	COVERAGE	COVERAGE_MAP	GAPS	%COVERAGE	%IDENTITY	DATABASE	ACCESSION	PRODUCT	RESISTANCE
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039729.1	656118	657620	+	eat(A)	1-1503/1503	===============	0/0	100.00	100.00	ncbi	NG_047762.1	ABC-F type ribosomal protection protein Eat(A)	PLEUROMUTILIN
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039729.1	2163439	2163987	-	aacA-ENT1	1-549/549	===============	0/0	100.00	100.00	ncbi	NG_052371.1	aminoglycoside 6'-N-acetyltransferase	AMINOGLYCOSIDE
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039729.1	2564038	2565516	-	msr(C)	1-1479/1479	===============	0/0	100.00	98.92	ncbi	NG_048003.1	ABC-F type ribosomal protection protein Msr(C)	MACROLIDE
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039730.1	43619	44197	-	vanX-M	1-579/609	===============	0/0	95.07	100.00	ncbi	NG_048495.1	D-Ala-D-Ala dipeptidase VanX-M	VANCOMYCIN
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039730.1	44203	45234	-	vanM	1-1032/1032	===============	0/0	100.00	100.00	ncbi	NG_048396.1	D-alanine--(R)-lactate ligase VanM	VANCOMYCIN
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039730.1	45227	46207	-	vanH-M	1-981/981	===============	0/0	100.00	100.00	ncbi	NG_048388.1	D-lactate dehydrogenase VanH-M	VANCOMYCIN
+GCF_010120755.1_ASM1012075v1_genomic.fna	NZ_CP039730.1	47306	48418	-	vanS-M	1-1113/1113	===============	0/0	100.00	100.00	ncbi	NG_048450.1	VanM-type vancomycin resistance histidine kinase VanS	VANCOMYCIN
diff -r 000000000000 -r d2590ecc4189 test-data/ariba/report.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/ariba/report.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,257 @@
+#ariba_ref_name	ref_name	gene	var_only	flag	reads	cluster	ref_len	ref_base_assembled	pc_ident	ctg	ctg_len	ctg_cov	known_var	var_type	var_seq_type	known_var_change	has_known_var	ref_ctg_change	ref_ctg_effect	ref_start	ref_end	ref_nt	ctg_start	ctg_end	ctg_nt	smtls_total_depth	smtls_nts	smtls_nts_depth	var_description	free_text
+AAC_3__IId.3004623.EU022314.1.0_861.5344	AAC_3__IId.3004623.EU022314.1.0_861.5344	1	0	27	256	AAC_3__II-	861	861	99.88	AAC_3__II-.l15.c4.ctg.1	1547	37.8	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli';AAC(3)-IId
+AAC_6___Ib4.3002577.AF445082.2788_3343.401	AAC_6___Ib4.3002577.AF445082.2788_3343.401	1	0	667	510	AAC_6___Ib+	555	555	99.64	AAC_6___Ib+.l15.c30.ctg.1	619	128.1	0	.	p	.	0	W87R	NONSYN	259	261	TGG	264	266	CGG	86;89;90	C,T,A;G;G	30,28,1;59;63	.	AAC(6')-Ib4;b"AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp."
+AAC_6___Ib4.3002577.AF445082.2788_3343.401	AAC_6___Ib4.3002577.AF445082.2788_3343.401	1	0	667	510	AAC_6___Ib+	555	555	99.64	AAC_6___Ib+.l15.c30.ctg.1	619	128.1	0	.	p	.	0	S102L	NONSYN	304	306	TCA	309	311	TTA	92;92;92	T;T;A	70;70;71	.	AAC(6')-Ib4;b"AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp."
+AAC_6___Ib4.3002577.AF445082.2788_3343.401	AAC_6___Ib4.3002577.AF445082.2788_3343.401	1	0	667	510	AAC_6___Ib+	555	555	99.64	AAC_6___Ib+.l15.c30.ctg.1	619	128.1	0	HET	.	.	.	G490T	.	490	490	G	495	495	G	139	G,T	57,46	.	AAC(6')-Ib4;b"AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp."
+BRP_MBL_.3001205.KC503911.1.9883_10249.5446	BRP_MBL_.3001205.KC503911.1.9883_10249.5446	1	0	27	132	BRP_MBL_	366	366	100.0	BRP_MBL_.l6.c4.ctg.1	1085	27.3	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BRP(MBL);b'A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region.'
+CRP.3000518.AP009048.1.4153663_4154296.4752	CRP.3000518.AP009048.1.4153663_4154296.4752	1	0	528	58	CRP	633	146	93.84	CRP.l15.c4.ctg.1	477	24.1	0	.	p	.	0	K29T	NONSYN	85	87	AAG	414	416	ACG	14;14;13	A;C;G	10;10;10	.	b'CRP is a global regulator that represses MdtEF multidrug efflux pump expression.';CRP
+CTX_M_15.3001878.AY044436.1435_2311.1430	CTX_M_15.3001878.AY044436.1435_2311.1430	1	0	27	274	CTX_M_-	876	876	100.0	CTX_M_-.l15.c4.ctg.1	1793	36.0	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTX-M-15;b'CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family'
+DHA_7.3002136.HQ456945.0_1140.1865	DHA_7.3002136.HQ456945.0_1140.1865	1	0	16	170	DHA_-	1140	796	100.0	DHA_-.l15.c4.ctg.1	1350	29.8	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'DHA-7 is a beta-lactamase found in the Enterobacteriaceae family';DHA-7
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T72A	SNP	72	72	T	86	86	A	506	A	125	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T113G	SNP	113	113	T	127	127	G	376	G	146	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T135C	SNP	135	135	T	149	149	C	343	C,T	116,40	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T137A	SNP	137	137	T	151	151	A	321	A,C	157,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A144G	SNP	144	144	A	158	158	G	311	G,A	120,41	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A152G	SNP	152	152	A	166	166	G	344	G	196	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C163A	SNP	163	163	C	177	177	A	353	A	216	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T174C	SNP	174	174	T	188	188	C	364	C	229	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G264C	SNP	264	264	G	278	278	C	415	C,T,G	306,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C274T	SNP	274	274	C	288	288	T	398	T,C	305,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G285T	SNP	285	285	G	299	299	T	394	T,C,A	299,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C302G	SNP	302	302	C	316	316	G	406	G	303	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G315.	DEL	315	315	G	328	328	C	409	C,A,T	302,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	.317A	INS	317	317	G	331	331	A	409	A,T	300,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A320G	SNP	320	320	A	334	334	G	422	G,A	316,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C331T	SNP	331	331	C	345	345	T	441	T,C	328,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C334T	SNP	334	334	C	348	348	T	445	T,A,G,C	326,1,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A344C	SNP	344	344	A	358	358	C	441	C,A	329,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C357T	SNP	357	357	C	371	371	T	446	T,C,G,A	260,76,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G363A	SNP	363	363	G	377	377	A	452	A,C	339,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T369A	SNP	369	369	T	383	383	A	479	A,C	347,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G543C	SNP	543	543	G	556	556	C	574	C,A	407,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A547C	SNP	547	547	A	560	560	C	572	C	407	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C550.	DEL	550	550	C	562	562	G	577	G,A,T	412,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A613T	SNP	613	613	A	625	625	T	657	T,C,A	504,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A626C	SNP	626	626	A	638	638	C	634	C,T	474,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C853T	SNP	853	853	C	865	865	T	658	T,G	473,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A877T	SNP	877	877	A	889	889	T	668	T,C,G	501,2,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G914A	SNP	914	914	G	926	926	A	673	A	477	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G924A	SNP	924	924	G	936	936	A	624	A,G	450,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1044A	SNP	1044	1044	C	1056	1056	A	534	A,G	414,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1173.	DEL	1173	1173	T	1184	1184	C	563	C,G	421,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1178T	SNP	1178	1178	C	1189	1189	T	575	T,C,A	438,2,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1211C	SNP	1211	1211	T	1222	1222	C	583	C,G,A	441,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A1220G	SNP	1220	1220	A	1231	1231	G	593	G,C,A,T	413,40,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1229C	SNP	1229	1229	T	1240	1240	C	599	C,G,A	417,39,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G1444A	SNP	1444	1444	G	1455	1455	A	639	A,G,T	491,2,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G1473A	SNP	1473	1473	G	1484	1484	A	659	A,G,T	502,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1486A	SNP	1486	1486	T	1497	1497	A	633	A,G,T	328,160,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A1503T	SNP	1503	1503	A	1514	1514	T	634	T,A	487,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1518T	SNP	1518	1518	C	1529	1529	T	623	T,C,G	483,1,2	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1547T	SNP	1547	1547	C	1558	1558	T	689	T,C	502,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A1713G	SNP	1713	1713	A	1724	1724	G	675	G,A,C	499,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1725.	DEL	1725	1725	C	1735	1735	G	643	G,T	483,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A1727C	SNP	1727	1727	A	1737	1737	C	640	C,A,G	475,1,2	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1729C	SNP	1729	1729	T	1739	1739	C	638	C,T	477,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1734G	SNP	1734	1734	C	1744	1744	G	644	G,T,A	482,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G1735A	SNP	1735	1735	G	1745	1745	A	645	A,T	487,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A1745G	SNP	1745	1745	A	1755	1755	G	659	G,A,T	497,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T1747C	SNP	1747	1747	T	1757	1757	C	650	C,T	490,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	.1866T	INS	1866	1866	A	1877	1877	T	636	T	475	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G1867C	SNP	1867	1867	G	1878	1878	C	637	C,A,T	473,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	.1872G	INS	1872	1872	A	1884	1884	G	651	G,A,C	476,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C1874A	SNP	1874	1874	C	1886	1886	A	652	A	476	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T2137C	SNP	2137	2137	T	2149	2149	C	554	C,G	426,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A2154G	SNP	2154	2154	A	2166	2166	G	581	G,T,A	435,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G2162A	SNP	2162	2162	G	2174	2174	A	590	A,G	443,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A2205G	SNP	2205	2205	A	2217	2217	G	596	G	454	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A2211G	SNP	2211	2211	A	2223	2223	G	605	G,C,A	456,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T2213C	SNP	2213	2213	T	2225	2225	C	625	C	462	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C2215G	SNP	2215	2215	C	2227	2227	G	622	G,T	462,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	T2265C	SNP	2265	2265	T	2277	2277	C	677	C,T,A	504,3,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	A2270C	SNP	2270	2270	A	2282	2282	C	685	C,G	510,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	G2293A	SNP	2293	2293	G	2305	2305	A	711	A,G	533,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C2339T	SNP	2339	2339	C	2351	2351	T	733	T,C,G	520,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	.	n	.	0	C2636T	SNP	2636	2636	C	2648	2648	T	644	T,G,C	463,1,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	1	SNP	n	G2032U	0	.	.	2032	2032	G	2044	2044	G	671	G	470	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164:0:0:G2032U:.:b'Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics'	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	1	SNP	n	G2032A	0	.	.	2032	2032	G	2044	2044	G	671	G	470	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164:0:0:G2032A:.:b'Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics'	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	1	SNP	n	G2032C	0	.	.	2032	2032	G	2044	2044	G	671	G	470	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164:0:0:G2032C:.:b'Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics'	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	1	SNP	n	G2447U	0	.	.	2447	2447	G	2459	2459	G	681	G	498	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164:0:0:G2447U:.:b'Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics'	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	C1595T,A	.	1595	1595	C	1606	1606	C	742	C,T,A	425,112,1	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	T1506C	.	1506	1506	T	1517	1517	T	634	T,C	427,58	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	T102C	.	102	102	T	116	116	T	433	T,C	116,28	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	A104G	.	104	104	A	118	118	A	433	A,G	117,28	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	A136G	.	136	136	G	150	150	A	322	A,G	118,40	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	G1483A	.	1483	1483	G	1494	1494	G	635	G,A	325,161	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	0	0	659	8302	Escherichia_coli_23S	2904	2792	97.1	Escherichia_coli_23S.l15.c17.ctg.1	2822	611.4	0	HET	.	.	.	T143C	.	143	143	C	157	157	T	311	T,C	122,40	.	Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	A43S	NONSYN	127	129	GCT	293	295	TCT	128;129;129	T;C;T,C	91;91;71,20	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	L190I	NONSYN	568	570	CTG	734	736	ATC	134;135;135	A,G;T;C	101,1;101;102	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	F195H	NONSYN	583	585	TTC	749	751	CAC	137;137;140	C;A;C	102;101;105	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	S198T	NONSYN	592	594	TCT	758	760	ACC	145;148;145	A;C;C	108;110;107	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	Q252A	NONSYN	754	756	CAG	920	922	GCG	104;103;103	G;C;G	83;82;82	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	S254T	NONSYN	760	762	TCT	926	928	ACC	102;102;109	A,T;C;C,T	81,1;82;81,1	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	.	p	.	0	K300N	NONSYN	898	900	AAG	1064	1066	AAC	141;140;144	A;A,T,G;C,G	102;99,1,1;101,1	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	HET	.	.	.	T960C	.	960	960	T	1126	1126	T	120	T,C	44,50	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	1	1	667	624	Escherichia_coli_EF_Tu	1185	1185	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1	1369	106.2	0	HET	.	.	.	T78A	.	78	78	T	244	244	T	110	T,A	67,9	.	Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa
+Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	1	1	528	182	Escherichia_coli_PtsI	1728	921	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2	1312	23.5	0	.	p	.	0	I360V	NONSYN	1078	1080	ATC	274	276	GTG	10;10;10	G;T;G	7;7;7	.	Escherichia coli PtsI with mutation conferring resistance to fosfomycin
+Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	1	1	528	182	Escherichia_coli_PtsI	1728	921	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2	1312	23.5	0	.	p	.	0	R367K	NONSYN	1099	1101	AGA	295	297	AAA	13;13;13	A;A;A	9;9;9	.	Escherichia coli PtsI with mutation conferring resistance to fosfomycin
+Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	1	1	528	182	Escherichia_coli_PtsI	1728	921	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2	1312	23.5	0	.	p	.	0	L374V	NONSYN	1120	1122	CTC	316	318	GTT	13;13;13	G;T;T	8;8;9	.	Escherichia coli PtsI with mutation conferring resistance to fosfomycin
+Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	1	1	528	182	Escherichia_coli_PtsI	1728	921	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2	1312	23.5	0	.	p	.	0	R403K	NONSYN	1207	1209	CGC	403	405	AAG	17;17;17	A;A;G	10;10;10	.	Escherichia coli PtsI with mutation conferring resistance to fosfomycin
+FosA6.3004111.KU254579.1.59421_59841.4755	FosA6.3004111.KU254579.1.59421_59841.4755	1	0	539	196	FosA-_1	420	420	98.81	FosA-_1.l15.c4.ctg.1	1646	27.2	0	.	p	.	0	I91V	NONSYN	271	273	ATC	808	810	GTC	47;48;49	G;T;C	36;38;39	.	b'fosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule.';FosA6
+FosA6.3004111.KU254579.1.59421_59841.4755	FosA6.3004111.KU254579.1.59421_59841.4755	1	0	539	196	FosA-_1	420	420	98.81	FosA-_1.l15.c4.ctg.1	1646	27.2	0	.	p	.	0	Q130P	NONSYN	388	390	CAG	925	927	CCG	79;79;80	C;C;G	60;60;61	.	b'fosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule.';FosA6
+FosA6.3004111.KU254579.1.59421_59841.4755	FosA6.3004111.KU254579.1.59421_59841.4755	1	0	539	196	FosA-_1	420	420	98.81	FosA-_1.l15.c4.ctg.1	1646	27.2	0	.	p	.	0	D138E	NONSYN	412	414	GAT	949	951	GAA	74;74;74	G;A;A	56;56;57	.	b'fosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule.';FosA6
+H_NS.3000676.BA000007.3.1737690_1738104.5476	H_NS.3000676.BA000007.3.1737690_1738104.5476	1	0	16	44	H_NS	414	111	93.69	H_NS.l15.c4.ctg.1	379	20.6	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	H-NS;b'H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters.'
+Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	1	1	27	328	Klebsiella_mutant_PhoP	672	672	100.0	Klebsiella_mutant_PhoP.l6.c4.ctg.1	1493	48.2	1	SNP	p	D191Y	0	.	.	571	573	GAC	889	891	GAC	104;104;102	G;A;C	77;77;76	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715:1:1:D191Y:.:b'A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge'	Klebsiella mutant PhoP conferring antibiotic resistance to colistin
+Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	1	0	539	320	Klebsiella_pneumoniae_KpnE	363	363	99.45	Klebsiella_pneumoniae_KpnE.l15.c4.ctg.1	1236	56.7	0	.	p	.	0	Q112K	NONSYN	334	336	CAG	736	738	AAG	119;119;119	A;A;G	95;95;95	.	b'KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan';Klebsiella pneumoniae KpnE
+Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	1	0	27	280	Klebsiella_pneumoniae_KpnF	330	330	100.0	Klebsiella_pneumoniae_KpnF.l15.c4.ctg.1	1352	45.9	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.';Klebsiella pneumoniae KpnF
+Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	1	0	539	510	Klebsiella_pneumoniae_KpnG	1173	1173	99.32	Klebsiella_pneumoniae_KpnG.l15.c4.ctg.1	1780	66.3	0	.	p	.	0	S137A	NONSYN	409	411	TCC	813	815	GCC	77;77;77	G;C;C	61;61;61	.	Klebsiella pneumoniae KpnG;b'KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin'
+Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	1	0	27	404	Klebsiella_pneumoniae_OmpK35	684	684	100.0	Klebsiella_pneumoniae_OmpK35.l15.c4.ctg.1	1394	66.2	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism.';Klebsiella pneumoniae OmpK35
+Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	1	0	539	584	Klebsiella_pneumoniae_OmpK36	1104	1104	99.82	Klebsiella_pneumoniae_OmpK36.l15.c4.ctg.1	1845	74.2	0	.	p	.	0	K195E	NONSYN	583	585	AAA	1061	1063	GAA	88;88;88	G;A;A	62;63;62	.	Klebsiella pneumoniae OmpK36;b'Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism.'
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	I70M	NONSYN	208	210	ATT	459	461	ATG	88;88;88	A;T;G	58;58;58	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	I128M	NONSYN	382	384	ATT	633	635	ATG	58;58;57	A;T;G,T	51;51;49,1	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	N230G	NONSYN	688	690	AAC	939	941	GGC	46;46;46	G;G;C	39;39;38	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	Q232fs	FSHIFT	694	694	C	945	945	C	46	C	39	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	.	MULTIPLE	697	699	ATG	953	956	CTAT	49;47;50;51	C;T;A;T	42;40;43;44	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	Q235H	NONSYN	703	705	CAG	960	962	CAC	47;45;45	C;A;C	39;38;38	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	T236fs	FSHIFT	706	706	A	963	963	A	45	A	37	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	A238_R239insI	INS	712	712	G	971	971	A	48	A	38	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	.	MULTIPLE	715	717	CGC	977	980	CAAA	48;48;48;48	C;A;A;A	38;37;37;37	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	E244D	NONSYN	730	732	GAA	993	995	GAC	55;55;54	G;A;C,A	38;39;36,4	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	G273_N274insLY	INS	817	817	G	1080	1080	G	50	G	40	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	.	INDELS	820	822	AAT	1090	1095	GCAGTA	52;52;53;56;56;56	G,A;C;A;G;T;A	42,1;43;42;46;46;46	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	.	MULTIPLE	823	825	GAC	1098	1101	AACG	56;56;57;57	A;A;C;G	46;46;47;45	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	1	0	539	526	Klebsiella_pneumoniae_OmpK37	1125	1125	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1	1846	66.2	0	.	p	.	0	.	MULTIPLE	829	831	GTG	1108	1112	GTATC	58;58;58;58;59	G;T;A;T;C	48;48;48;47;49	.	b'Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.';Klebsiella pneumoniae OmpK37
+NDM_1.3000589.FN396876.2406_3219.4450	NDM_1.3000589.FN396876.2406_3219.4450	1	0	27	186	NDM_-	813	813	100.0	NDM_-.l15.c4.ctg.1	1601	27.2	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NDM-1;b'NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics.'
+OXA_1.3001396.JN420336.1.1399_2230.4668	OXA_1.3001396.JN420336.1.1399_2230.4668	1	0	27	188	OXA_-_3	831	831	100.0	OXA_-_3.l15.c4.ctg.1	1942	22.5	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'OXA-1 is a beta-lactamase found in E. coli';OXA-1
+SHV_182.3001364.KP050489.0_861.2124	SHV_182.3001364.KP050489.0_861.2124	1	0	539	376	SHV_-	861	861	99.88	SHV_-.l15.c4.ctg.1	2154	41.0	0	.	p	.	0	T102S	NONSYN	304	306	ACG	805	807	TCG	52;52;52	T;C;G	43;43;43	.	SHV-182;b'From the Lahey list of beta-lactamases.'
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	F92S	NONSYN	274	276	TTC	820	822	TCC	77;77;77	T;C;C	63;63;62	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	G103A	NONSYN	307	309	GGC	853	855	GCC	66;66;66	G;C;C	54;54;54	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	Q136K	NONSYN	406	408	CAA	952	954	AAA	55;55;57	A;A;A	42;42;44	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	P145T	NONSYN	433	435	CCC	979	981	ACC	54;54;53	A;C;C	39;38;35	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	N153S	NONSYN	457	459	AAC	1003	1005	AGC	49;49;49	A;G;C	39;39;39	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	T162A	NONSYN	484	486	ACT	1030	1032	GCG	48;48;48	G;C;G,A	38;38;36,1	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	Q175fs	FSHIFT	523	523	C	1068	1068	C	42	C	33	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	L179R	NONSYN	535	537	CTC	1079	1081	CGC	42;42;42	C;G;C	33;32;31	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	.	MULTIPLE	554	555	CG	1097	1098	TT	42;42	T;T	33;32	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	P189T	NONSYN	565	567	CCC	1108	1110	ACC	39;40;40	A;C;C	31;32;32	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	V210L	NONSYN	628	630	GTG	1171	1173	CTG	47;47;46	C;T;G	34;33;33	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004041.AJ318073.1.793_1990.3994	acrA.3004041.AJ318073.1.793_1990.3994	1	0	539	534	acrA	1197	1197	97.74	acrA.l15.c4.ctg.1	2009	61.7	0	.	p	.	0	A234G	NONSYN	700	702	GCC	1243	1245	GGC	54;54;58	G;G;C	39;37;40	.	b'AcrA is a subunit of the AcrAB multidrug efflux system that in K. pneumoniae, which is encoded by the acrRAB operon.';Klebsiella pneumoniae acrA
+acrA.3004042.DQ679966.299_1493.3995	acrA.3004042.DQ679966.299_1493.3995	1	0	528	44	acrA_1	1194	159	91.19	acrA_1.l15.c4.ctg.1	355	20.0	0	.	p	.	0	Q36H	NONSYN	106	108	CAG	302	304	CAC	3;3;3	C;A;C	3;3;3	.	Enterobacter cloacae acrA;b'AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. cloacae.'
+acrA.3004042.DQ679966.299_1493.3995	acrA.3004042.DQ679966.299_1493.3995	1	0	528	44	acrA_1	1194	159	91.19	acrA_1.l15.c4.ctg.1	355	20.0	0	.	p	.	0	A37M	NONSYN	109	111	GCG	305	307	ATG	3;3;3	A;T;G	3;3;3	.	Enterobacter cloacae acrA;b'AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. cloacae.'
+acrA.3004042.DQ679966.299_1493.3995	acrA.3004042.DQ679966.299_1493.3995	1	0	528	44	acrA_1	1194	159	91.19	acrA_1.l15.c4.ctg.1	355	20.0	0	.	p	.	0	V42I	NONSYN	124	126	GTT	320	322	ATT	3;3;3	A;T;T	3;3;3	.	Enterobacter cloacae acrA;b'AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. cloacae.'
+acrA.3004042.DQ679966.299_1493.3995	acrA.3004042.DQ679966.299_1493.3995	1	0	528	44	acrA_1	1194	159	91.19	acrA_1.l15.c4.ctg.1	355	20.0	0	.	p	.	0	E48A	NONSYN	142	144	GAA	338	340	GCA	3;3;3	G;C;A	3;3;3	.	Enterobacter cloacae acrA;b'AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. cloacae.'
+acrR.3003373.CP000647.489264_489915.2069	acrR.3003373.CP000647.489264_489915.2069	1	1	27	398	acrR	651	651	99.85	acrR.l6.c4.ctg.1	1331	65.8	1	SNP	p	M109I	0	.	.	325	327	ATG	652	654	ATG	69;69;69	A;T;G	57;54;57	acrR.3003373.CP000647.489264_489915.2069:1:1:M109I:.:b'AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance.'	Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance
+acrR.3003373.CP000647.489264_489915.2069	acrR.3003373.CP000647.489264_489915.2069	1	1	27	398	acrR	651	651	99.85	acrR.l6.c4.ctg.1	1331	65.8	1	SNP	p	Y114F	0	.	.	340	342	TAT	667	669	TAT	61;61;66	T;A;T	52;52;56	acrR.3003373.CP000647.489264_489915.2069:1:1:Y114F:.:b'AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance.'	Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance
+acrR.3003373.CP000647.489264_489915.2069	acrR.3003373.CP000647.489264_489915.2069	1	1	27	398	acrR	651	651	99.85	acrR.l6.c4.ctg.1	1331	65.8	1	SNP	p	V165I	0	.	.	493	495	GTG	820	822	GTG	69;69;70	G;T;G	58;57;58	acrR.3003373.CP000647.489264_489915.2069:1:1:V165I:.:b'AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance.'	Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance
+catB3.3002676.JX101693.1.58200_58833.5450	catB3.3002676.JX101693.1.58200_58833.5450	1	0	16	134	catB3	633	442	100.0	catB3.l15.c4.ctg.1	939	31.5	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	catB3;b'catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli'
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	N2S	NONSYN	4	6	AAT	213	215	AGT	11;13;13	A;G;T	8;9;9	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	A26V	NONSYN	76	78	GCA	285	287	GTC	14;15;15	G;T;C	10;10;10	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	N40S	NONSYN	118	120	AAT	327	329	AGC	17;17;17	A;G;C	12;11;12	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	K72N	NONSYN	214	216	AAA	423	425	AAT	17;17;17	A;A;T	12;12;12	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	I73V	NONSYN	217	219	ATT	426	428	GTG	17;17;17	G;T;G	12;12;12	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	E101D	NONSYN	301	303	GAA	510	512	GAC	20;20;20	G;A;C	13;13;13	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	0	.	p	.	0	G146A	NONSYN	436	438	GGC	645	647	GCG	10;10;10	G;C;G	8;8;8	.	Escherichia coli fabG mutations conferring resistance to triclosan
+fabG.3004049.U00096.3.1150669_1151404.5523	fabG.3004049.U00096.3.1150669_1151404.5523	1	1	528	42	fabG	735	556	92.27	fabG.l15.c4.ctg.1	765	12.3	1	SNP	p	Y151V	0	.	.	451	453	TAC	660	662	TAC	10;10;9	T;A;C	8;8;7	fabG.3004049.U00096.3.1150669_1151404.5523:1:1:Y151V:.:b'fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan.'	Escherichia coli fabG mutations conferring resistance to triclosan
+gyrA.3003940.AE005674.2.2352231_2354859.5265	gyrA.3003940.AE005674.2.2352231_2354859.5265	1	1	528	192	gyrA_9	2628	398	92.71	gyrA_9.l6.c17.ctg.2	724	40.9	0	.	p	.	0	S19N	NONSYN	55	57	AGC	379	381	AAC	102;100;99	A;A;C	68;67;67	.	Shigella flexneri gyrA conferring resistance to fluoroquinolones
+gyrA.3003940.AE005674.2.2352231_2354859.5265	gyrA.3003940.AE005674.2.2352231_2354859.5265	1	1	528	192	gyrA_9	2628	398	92.71	gyrA_9.l6.c17.ctg.2	724	40.9	0	.	p	.	0	S83F	NONSYN	247	249	TCG	571	573	TTC	16;16;16	T;T;C	14;14;15	.	Shigella flexneri gyrA conferring resistance to fluoroquinolones
+gyrA.3003940.AE005674.2.2352231_2354859.5265	gyrA.3003940.AE005674.2.2352231_2354859.5265	1	1	528	192	gyrA_9	2628	398	92.71	gyrA_9.l6.c17.ctg.2	724	40.9	0	.	p	.	0	D87A	NONSYN	259	261	GAC	583	585	GCC	16;16;16	G;C;C	15;15;15	.	Shigella flexneri gyrA conferring resistance to fluoroquinolones
+gyrA.3003940.AE005674.2.2352231_2354859.5265	gyrA.3003940.AE005674.2.2352231_2354859.5265	1	1	528	192	gyrA_9	2628	398	92.71	gyrA_9.l6.c17.ctg.2	724	40.9	1	SNP	p	N57K	0	.	.	169	171	AAT	493	495	AAT	43;42;42	A;A;T,G	30;29;28,1	gyrA.3003940.AE005674.2.2352231_2354859.5265:1:1:N57K:.:b'Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics.'	Shigella flexneri gyrA conferring resistance to fluoroquinolones
+gyrA.3004334.AE006468.2.2373709_2376346.5394	gyrA.3004334.AE006468.2.2373709_2376346.5394	1	1	528	210	gyrA_8	2637	344	92.44	gyrA_8.l15.c4.ctg.2	345	6.7	0	.	p	.	0	N628D	NONSYN	1882	1884	AAC	163	165	GAT	8;8;8	G;A;T	4;4;4	.	Salmonella enterica gyrA with mutation conferring resistance to triclosan
+gyrA.3004334.AE006468.2.2373709_2376346.5394	gyrA.3004334.AE006468.2.2373709_2376346.5394	1	1	528	210	gyrA_8	2637	344	92.44	gyrA_8.l15.c4.ctg.2	345	6.7	0	.	p	.	0	D678E	NONSYN	2032	2034	GAC	313	315	GAA	3;3;3	G;A;A	3;3;3	.	Salmonella enterica gyrA with mutation conferring resistance to triclosan
+oqxA.3003922.EU370913.1.46651_47827.5460	oqxA.3003922.EU370913.1.46651_47827.5460	1	0	27	474	oqxA	1176	1176	99.23	oqxA.l6.c4.ctg.1	2013	55.6	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	oqxA;b'RND efflux pump conferring resistance to fluoroquinolone'
+oqxB.3003923.EU370913.1.47850_51003.5462	oqxB.3003923.EU370913.1.47850_51003.5462	1	0	539	944	oqxB	3153	3153	98.86	oqxB.l15.c4.ctg.1	4068	57.2	0	.	p	.	0	G148N	NONSYN	442	444	GGC	956	958	AAC	56;56;57	A;A;C	45;45;46	.	oqxB;b'RND efflux pump conferring resistance to fluoroquinolone'
+oqxB.3003923.EU370913.1.47850_51003.5462	oqxB.3003923.EU370913.1.47850_51003.5462	1	0	539	944	oqxB	3153	3153	98.86	oqxB.l15.c4.ctg.1	4068	57.2	0	.	p	.	0	G540S	NONSYN	1618	1620	GGC	2132	2134	AGC	62;62;62	A;G;C	45;45;45	.	oqxB;b'RND efflux pump conferring resistance to fluoroquinolone'
+oqxB.3003923.EU370913.1.47850_51003.5462	oqxB.3003923.EU370913.1.47850_51003.5462	1	0	539	944	oqxB	3153	3153	98.86	oqxB.l15.c4.ctg.1	4068	57.2	0	.	p	.	0	D749E	NONSYN	2245	2247	GAT	2759	2761	GAG	64;64;64	G;A;G,C	49;47;49,1	.	oqxB;b'RND efflux pump conferring resistance to fluoroquinolone'
+oqxB.3003923.EU370913.1.47850_51003.5462	oqxB.3003923.EU370913.1.47850_51003.5462	1	0	539	944	oqxB	3153	3153	98.86	oqxB.l15.c4.ctg.1	4068	57.2	0	.	p	.	0	Y783F	NONSYN	2347	2349	TAC	2861	2863	TTC	55;55;54	T;T,G;C	45;43,1;43	.	oqxB;b'RND efflux pump conferring resistance to fluoroquinolone'
+oqxB.3003923.EU370913.1.47850_51003.5462	oqxB.3003923.EU370913.1.47850_51003.5462	1	0	539	944	oqxB	3153	3153	98.86	oqxB.l15.c4.ctg.1	4068	57.2	0	.	p	.	0	P1049L	NONSYN	3145	3147	CCC	3659	3661	CTC	12;12;11	C;T;C	11;10;10	.	oqxB;b'RND efflux pump conferring resistance to fluoroquinolone'
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	K5E	0	.	.	13	15	AAG	455	457	AAG	139;139;140	A;A;G	102;100;101	ramR.3003380.CP000647.1.622039_622621.4572:1:1:K5E:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	A16D	0	.	.	46	48	GCT	488	490	GCT	154;154;154	G;C;T	106;107;106	ramR.3003380.CP000647.1.622039_622621.4572:1:1:A16D:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	A19V	0	.	.	55	57	GCG	497	499	GCG	147;147;147	G,T;C;G	106,1;107;106	ramR.3003380.CP000647.1.622039_622621.4572:1:1:A19V:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	T43M	0	.	.	127	129	ACG	569	571	ACG	120;115;115	A;C,T;G	94;91,1;93	ramR.3003380.CP000647.1.622039_622621.4572:1:1:T43M:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	I88N	0	.	.	262	264	ATC	704	706	ATC	92;90;90	A;T;C	71;72;71	ramR.3003380.CP000647.1.622039_622621.4572:1:1:I88N:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	G96D	0	.	.	286	288	GGC	728	730	GGC	85;85;82	G;G;C	66;65;65	ramR.3003380.CP000647.1.622039_622621.4572:1:1:G96D:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+ramR.3003380.CP000647.1.622039_622621.4572	ramR.3003380.CP000647.1.622039_622621.4572	1	1	27	392	ramR_1	582	582	100.0	ramR_1.l15.c4.ctg.1	1721	53.5	1	SNP	p	T162I	0	.	.	484	486	ACC	926	928	ACC	118;118;118	A;C;C	84;84;83	ramR.3003380.CP000647.1.622039_622621.4572:1:1:T162I:.:b'RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.'	Klebsiella pneumoniae ramR mutants
+rmtC.3000861.KJ476816.1.79_925.3396	rmtC.3000861.KJ476816.1.79_925.3396	1	0	27	254	rmtC	846	846	100.0	rmtC.l15.c17.ctg.1	1579	36.8	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA.';rmtC
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	608	94.08	rpoB.l15.c4.ctg.1	1275	30.1	0	.	p	.	0	Q83K	NONSYN	247	249	CAG	912	914	AAA	55;54;54	A;A;A	41;41;41	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	608	94.08	rpoB.l15.c4.ctg.1	1275	30.1	1	SNP	p	V146F	0	.	.	436	438	GTT	1101	1103	GTT	13;12;12	G;T;T	13;12;12	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:V146F:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	V242I	NONSYN	724	726	GTG	16	18	ATT	2;2;2	A;T;T	2;2;2	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	V282I	NONSYN	844	846	GTC	136	138	ATC	3;3;3	A;T;C	3;3;3	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	L284H	NONSYN	850	852	CTG	142	144	CAT	3;3;3	C;A;T	3;3;3	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	V297A	NONSYN	889	891	GTT	181	183	GCG	3;3;3	G;C;G	3;3;3	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	S305A	NONSYN	913	915	TCT	205	207	GCG	5;5;5	G;C;G	5;5;5	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	A312P	NONSYN	934	936	GCA	226	228	CCG	6;6;6	C;C;G	5;6;6	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	L351V	NONSYN	1051	1053	TTA	343	345	GTA	7;7;7	G;T;A	7;7;7	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	E412D	NONSYN	1234	1236	GAA	526	528	GAC	26;26;25	G;A;C	22;22;22	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	D427E	NONSYN	1279	1281	GAT	571	573	GAA	30;30;30	G;A;A	27;27;27	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	D596N	NONSYN	1786	1788	GAC	1078	1080	AAC	60;63;64	A;A;C	46;48;50	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	E626N	NONSYN	1876	1878	GAA	1168	1170	AAC	63;63;63	A;A;C	48;48;48	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	V723T	NONSYN	2167	2169	GTC	1459	1461	ACC	53;53;52	A;C;C	43;42;42	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	V777I	NONSYN	2329	2331	GTT	1621	1623	ATT	24;24;24	A;T;T	16;18;16	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	R976Y	NONSYN	2926	2928	CGT	2218	2220	TAC	22;21;21	T;A;C	18;17;17	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	A981S	NONSYN	2941	2943	GCC	2233	2235	TCC	23;23;23	T;C;C	18;18;18	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	Y1087H	NONSYN	3259	3261	TAC	2551	2553	CAC	16;16;16	C;A;C	11;11;11	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	E1089A	NONSYN	3265	3267	GAA	2557	2559	GCT	17;17;17	G;C;T	12;12;12	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	S1162N	NONSYN	3484	3486	AGT	2776	2778	AAT	30;30;32	A;A;T	21;20;21	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	M1170L	NONSYN	3508	3510	ATG	2800	2802	CTG	34;34;34	C;T;G	22;24;22	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	K1200Q	NONSYN	3598	3600	AAA	2890	2892	CAG	37;37;37	C;A;G	27;27;26	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	R1211T	NONSYN	3631	3633	CGC	2923	2925	ACC	36;33;33	A;C;C	27;25;25	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	0	.	p	.	0	Y1213F	NONSYN	3637	3639	TAC	2929	2931	TTT	34;34;35	T;T;T	25;25;25	.	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	Q513L	0	.	.	1537	1539	CAG	829	831	CAG	77;77;77	C;A;G	56;56;56	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:Q513L:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	Q513P	0	.	.	1537	1539	CAG	829	831	CAG	77;77;77	C;A;G	56;56;56	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:Q513P:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	H526Y	0	.	.	1576	1578	CAC	868	870	CAC	84;83;83	C;A,G;C	59;58,1;59	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:H526Y:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	R529C	0	.	.	1585	1587	CGT	877	879	CGT	85;86;86	C;G;T	60;61;61	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:R529C:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	R529S	0	.	.	1585	1587	CGT	877	879	CGT	85;86;86	C;G;T	60;61;61	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:R529S:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	S531F	0	.	.	1591	1593	TCC	883	885	TCC	89;87;86	T;C;C,T	62;61;59,1	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:S531F:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	L533P	0	.	.	1597	1599	CTC	889	891	CTC	87;87;87	C;T;C	61;59;61	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:L533P:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	P564L	0	.	.	1690	1692	CCT	982	984	CCT	67;67;67	C;C;T	51;51;53	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:P564L:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rpoB.3003288.BA000007.3.4990267_4994296.5493	rpoB.3003288.BA000007.3.4990267_4994296.5493	1	1	513	678	rpoB	4029	3321	93.44	rpoB.l15.c4.ctg.2	3739	33.7	1	SNP	p	R687H	0	.	.	2059	2061	CGT	1351	1353	CGT	58;58;58	C;G;T	50;49;49	rpoB.3003288.BA000007.3.4990267_4994296.5493:1:1:R687H:.:b'Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin'	Escherichia coli rpoB mutants conferring resistance to rifampicin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	G179A	SNP	179	179	G	266	266	A	723	A	525	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C191T	SNP	191	191	C	278	278	T	724	T,C	512,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C254T	SNP	254	254	C	341	341	T	666	T,C	513,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C302T	SNP	302	302	C	389	389	T	670	T	521	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A406G	SNP	406	406	A	493	493	G	713	G,C	536,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A410G	SNP	410	410	A	497	497	G	699	G,A,T	341,190,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T412C	SNP	412	412	T	499	499	C	706	C	533	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C672T	SNP	672	672	C	759	759	T	749	T,C	548,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	G720A	SNP	720	720	G	807	807	A	693	A,T,G	519,4,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A722C	SNP	722	722	A	809	809	C	689	C	528	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A893T	SNP	893	893	A	980	980	T	679	T	519	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1069C	SNP	1069	1069	T	1156	1156	C	819	C	590	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1074A	SNP	1074	1074	C	1161	1161	A	820	A	590	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1086T	SNP	1086	1086	A	1173	1173	T	813	T	584	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1087T	SNP	1087	1087	C	1174	1174	T	805	T,C	384,193	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1091G	SNP	1091	1091	A	1178	1178	G	811	G,T,A	572,2,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1112G	SNP	1112	1112	A	1199	1199	G	796	G,A	571,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1138C	SNP	1138	1138	T	1225	1225	C	733	C,T	554,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1273A	SNP	1273	1273	T	1360	1360	A	584	A	454	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1288C	SNP	1288	1288	T	1375	1375	C	565	C	443	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1293T	SNP	1293	1293	A	1380	1380	T	571	T,C	449,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1296T	SNP	1296	1296	A	1383	1383	T	569	T,A,C	402,43,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1328T	SNP	1328	1328	A	1415	1415	T	584	T,A	464,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1347A	SNP	1347	1347	T	1434	1434	A	588	A,C,T	456,1,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	G1363A	SNP	1363	1363	G	1450	1450	A	605	A,G	154,301	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1379T	SNP	1379	1379	C	1466	1466	T	716	T	550	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1443G	SNP	1443	1443	A	1530	1530	G	857	G,T	611,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	G1451C	SNP	1451	1451	G	1538	1538	C	851	C	610	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	A1454G	SNP	1454	1454	A	1541	1541	G	846	G,C	605,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1457.	DEL	1457	1457	C	1543	1543	G	831	G,T,A	600,1,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	G1466.	DEL	1466	1466	G	1551	1551	T	820	T,A	604,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1470T	SNP	1470	1470	C	1555	1555	T	822	T	605	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	C1471G	SNP	1471	1471	C	1556	1556	G	823	G,C	605,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1474C	SNP	1474	1474	T	1559	1559	C	821	C,G	598,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	.	n	.	0	T1480C	SNP	1480	1480	T	1565	1565	C	820	C	590	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	1	SNP	n	C1065U	0	.	.	1065	1065	C	1152	1152	C	819	C,T	591,1	rrsD.3003512.AE006468.3570463_3572006.3227:0:0:C1065U:.:b'Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin'	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	1	SNP	n	C1192U	0	.	.	1192	1192	C	1279	1279	C	713	C	523	rrsD.3003512.AE006468.3570463_3572006.3227:0:0:C1192U:.:b'Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin'	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	T526A	.	526	526	T	613	613	T	821	T,A	441,136	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	C527G,T,A	.	527	527	C	614	614	C	821	C,G,T,A	434,138,1,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	C559T	.	559	559	C	646	646	C	781	C,T	510,63	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	C1071A,T,G	.	1071	1071	C	1158	1158	C	806	C,A,T,G	240,342,1,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	C1072T	.	1072	1072	T	1159	1159	C	807	C,T	310,274	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	A1073G,T	.	1073	1073	G	1160	1160	A	807	A,G,T	310,269,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	G1234A	.	1234	1234	G	1321	1321	G	654	G,A	418,54	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	G536C	.	536	536	G	623	623	G	826	G,C	440,134	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	G409T,A,C	.	409	409	T	496	496	G	699	G,T,A,C	462,72,1,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	A537T	.	537	537	A	624	624	A	826	A,T	444,136	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	G926A,T	.	926	926	G	1013	1013	G	698	G,A,T	474,65,2	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+rrsD.3003512.AE006468.3570463_3572006.3227	rrsD.3003512.AE006468.3570463_3572006.3227	0	0	659	6088	rrsB+	1544	1544	97.22	rrsB+.l15.c17.ctg.1	1693	765.7	0	HET	.	.	.	A1089C,T,G	.	1089	1089	A	1176	1176	A	807	A,C,T,G	312,194,74,1	.	Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin
+sul1.3000410.JF969163.1053_1893.340	sul1.3000410.JF969163.1053_1893.340	1	0	27	360	sul1	840	840	99.88	sul1.l15.c17.ctg.1	1783	43.9	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	b'Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons.';sul1
diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_abricate.json
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_abricate.json	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,1 @@
+[{"input_file_name": "GCF_010120755.1_ASM1012075v1_genomic", "gene_symbol": "eat(A)", "gene_name": "ABC-F type ribosomal protection protein Eat(A)", "reference_database_id": "ncbi", "reference_database_version": "db_v_1", "reference_accession": "NG_047762.1", "analysis_software_name": "abricate", "analysis_software_version": "tool_v_1", "sequence_identity": "100.0", "input_sequence_id": "NZ_CP039729.1", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "656118", "input_gene_stop": "657620", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "+", "coverage_depth": "", "coverage_percentage": "100.0", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "PLEUROMUTILIN", "antimicrobial_agent": "", "resistance_mechanism": ""}, {"input_file_name": "GCF_010120755.1_ASM1012075v1_genomic", "gene_symbol": "aacA-ENT1", "gene_name": "aminoglycoside 6'-N-acetyltransferase", "reference_database_id": "ncbi", "reference_database_version": "db_v_1", "reference_accession": "NG_052371.1", "analysis_software_name": "abricate", "analysis_software_version": "tool_v_1", "sequence_identity": "100.0", "input_sequence_id": "NZ_CP039729.1", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "2163439", "input_gene_stop": "2163987", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "-", "coverage_depth": "", "coverage_percentage": "100.0", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "AMINOGLYCOSIDE", "antimicrobial_agent": "", "resistance_mechanism": ""}, {"input_file_name": "GCF_010120755.1_ASM1012075v1_genomic", "gene_symbol": "msr(C)", "gene_name": "ABC-F type ribosomal protection protein Msr(C)", "reference_database_id": "ncbi", "reference_database_version": "db_v_1", "reference_accession": "NG_048003.1", "analysis_software_name": "abricate", "analysis_software_version": "tool_v_1", "sequence_identity": "98.92", "input_sequence_id": "NZ_CP039729.1", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "2564038", "input_gene_stop": "2565516", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "-", "coverage_depth": "", "coverage_percentage": "100.0", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "MACROLIDE", "antimicrobial_agent": "", "resistance_mechanism": ""}, {"input_file_name": "GCF_010120755.1_ASM1012075v1_genomic", "gene_symbol": "vanX-M", "gene_name": "D-Ala-D-Ala dipeptidase VanX-M", "reference_database_id": "ncbi", 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diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_abricate.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_abricate.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,8 @@
+input_file_name	gene_symbol	gene_name	reference_database_id	reference_database_version	reference_accession	analysis_software_name	analysis_software_version	sequence_identity	input_sequence_id	input_protein_start	input_protein_stop	input_gene_start	input_gene_stop	reference_protein_start	reference_protein_stop	reference_gene_start	reference_gene_stop	strand_orientation	coverage_depth	coverage_percentage	coverage_ratio	reference_gene_length	reference_protein_length	input_gene_length	input_protein_length	drug_class	antimicrobial_agent	resistance_mechanism
+GCF_010120755.1_ASM1012075v1_genomic	eat(A)	ABC-F type ribosomal protection protein Eat(A)	ncbi	db_v_1	NG_047762.1	abricate	tool_v_1	100.0	NZ_CP039729.1			656118	657620					+		100.0						PLEUROMUTILIN		
+GCF_010120755.1_ASM1012075v1_genomic	aacA-ENT1	aminoglycoside 6'-N-acetyltransferase	ncbi	db_v_1	NG_052371.1	abricate	tool_v_1	100.0	NZ_CP039729.1			2163439	2163987					-		100.0						AMINOGLYCOSIDE		
+GCF_010120755.1_ASM1012075v1_genomic	msr(C)	ABC-F type ribosomal protection protein Msr(C)	ncbi	db_v_1	NG_048003.1	abricate	tool_v_1	98.92	NZ_CP039729.1			2564038	2565516					-		100.0						MACROLIDE		
+GCF_010120755.1_ASM1012075v1_genomic	vanX-M	D-Ala-D-Ala dipeptidase VanX-M	ncbi	db_v_1	NG_048495.1	abricate	tool_v_1	100.0	NZ_CP039730.1			43619	44197					-		95.07						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanM	D-alanine--(R)-lactate ligase VanM	ncbi	db_v_1	NG_048396.1	abricate	tool_v_1	100.0	NZ_CP039730.1			44203	45234					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanH-M	D-lactate dehydrogenase VanH-M	ncbi	db_v_1	NG_048388.1	abricate	tool_v_1	100.0	NZ_CP039730.1			45227	46207					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanS-M	VanM-type vancomycin resistance histidine kinase VanS	ncbi	db_v_1	NG_048450.1	abricate	tool_v_1	100.0	NZ_CP039730.1			47306	48418					-		100.0						VANCOMYCIN		
diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_ariba.json
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_ariba.json	Tue Mar 16 12:38:42 2021 +0000
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diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_ariba.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_ariba.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,257 @@
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+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	FosA6	FosA6.3004111.KU254579.1.59421_59841.4755	dbname	db_v_1	FosA6.3004111.KU254579.1.59421_59841.4755	ariba	ariba_v1	98.81	FosA-_1.l15.c4.ctg.1										27.2			420						
+ariba_report	FosA6	FosA6.3004111.KU254579.1.59421_59841.4755	dbname	db_v_1	FosA6.3004111.KU254579.1.59421_59841.4755	ariba	ariba_v1	98.81	FosA-_1.l15.c4.ctg.1										27.2			420						
+ariba_report	FosA6	FosA6.3004111.KU254579.1.59421_59841.4755	dbname	db_v_1	FosA6.3004111.KU254579.1.59421_59841.4755	ariba	ariba_v1	98.81	FosA-_1.l15.c4.ctg.1										27.2			420						
+ariba_report	H_NS	H_NS.3000676.BA000007.3.1737690_1738104.5476	dbname	db_v_1	H_NS.3000676.BA000007.3.1737690_1738104.5476	ariba	ariba_v1	93.69	H_NS.l15.c4.ctg.1										20.6			414						
+ariba_report	Klebsiella_mutant_PhoP	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	dbname	db_v_1	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	ariba	ariba_v1	100.0	Klebsiella_mutant_PhoP.l6.c4.ctg.1										48.2			672						
+ariba_report	Klebsiella_pneumoniae_KpnE	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	dbname	db_v_1	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	ariba	ariba_v1	99.45	Klebsiella_pneumoniae_KpnE.l15.c4.ctg.1										56.7			363						
+ariba_report	Klebsiella_pneumoniae_KpnF	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	dbname	db_v_1	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_KpnF.l15.c4.ctg.1										45.9			330						
+ariba_report	Klebsiella_pneumoniae_KpnG	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	dbname	db_v_1	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	ariba	ariba_v1	99.32	Klebsiella_pneumoniae_KpnG.l15.c4.ctg.1										66.3			1173						
+ariba_report	Klebsiella_pneumoniae_OmpK35	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	dbname	db_v_1	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_OmpK35.l15.c4.ctg.1										66.2			684						
+ariba_report	Klebsiella_pneumoniae_OmpK36	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	dbname	db_v_1	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	ariba	ariba_v1	99.82	Klebsiella_pneumoniae_OmpK36.l15.c4.ctg.1										74.2			1104						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	NDM_1	NDM_1.3000589.FN396876.2406_3219.4450	dbname	db_v_1	NDM_1.3000589.FN396876.2406_3219.4450	ariba	ariba_v1	100.0	NDM_-.l15.c4.ctg.1										27.2			813						
+ariba_report	OXA_1	OXA_1.3001396.JN420336.1.1399_2230.4668	dbname	db_v_1	OXA_1.3001396.JN420336.1.1399_2230.4668	ariba	ariba_v1	100.0	OXA_-_3.l15.c4.ctg.1										22.5			831						
+ariba_report	SHV_182	SHV_182.3001364.KP050489.0_861.2124	dbname	db_v_1	SHV_182.3001364.KP050489.0_861.2124	ariba	ariba_v1	99.88	SHV_-.l15.c4.ctg.1										41.0			861						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrR	acrR.3003373.CP000647.489264_489915.2069	dbname	db_v_1	acrR.3003373.CP000647.489264_489915.2069	ariba	ariba_v1	99.85	acrR.l6.c4.ctg.1										65.8			651						
+ariba_report	acrR	acrR.3003373.CP000647.489264_489915.2069	dbname	db_v_1	acrR.3003373.CP000647.489264_489915.2069	ariba	ariba_v1	99.85	acrR.l6.c4.ctg.1										65.8			651						
+ariba_report	acrR	acrR.3003373.CP000647.489264_489915.2069	dbname	db_v_1	acrR.3003373.CP000647.489264_489915.2069	ariba	ariba_v1	99.85	acrR.l6.c4.ctg.1										65.8			651						
+ariba_report	catB3	catB3.3002676.JX101693.1.58200_58833.5450	dbname	db_v_1	catB3.3002676.JX101693.1.58200_58833.5450	ariba	ariba_v1	100.0	catB3.l15.c4.ctg.1										31.5			633						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3004334.AE006468.2.2373709_2376346.5394	dbname	db_v_1	gyrA.3004334.AE006468.2.2373709_2376346.5394	ariba	ariba_v1	92.44	gyrA_8.l15.c4.ctg.2										6.7			2637						
+ariba_report	gyrA	gyrA.3004334.AE006468.2.2373709_2376346.5394	dbname	db_v_1	gyrA.3004334.AE006468.2.2373709_2376346.5394	ariba	ariba_v1	92.44	gyrA_8.l15.c4.ctg.2										6.7			2637						
+ariba_report	oqxA	oqxA.3003922.EU370913.1.46651_47827.5460	dbname	db_v_1	oqxA.3003922.EU370913.1.46651_47827.5460	ariba	ariba_v1	99.23	oqxA.l6.c4.ctg.1										55.6			1176						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	rmtC	rmtC.3000861.KJ476816.1.79_925.3396	dbname	db_v_1	rmtC.3000861.KJ476816.1.79_925.3396	ariba	ariba_v1	100.0	rmtC.l15.c17.ctg.1										36.8			846						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	94.08	rpoB.l15.c4.ctg.1										30.1			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	94.08	rpoB.l15.c4.ctg.1										30.1			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rrsD	rrsD.3003512.AE006468.3570463_3572006.3227	dbname	db_v_1	rrsD.3003512.AE006468.3570463_3572006.3227	ariba	ariba_v1	97.22	rrsB+.l15.c17.ctg.1										765.7			1544						
+ariba_report	rrsD	rrsD.3003512.AE006468.3570463_3572006.3227	dbname	db_v_1	rrsD.3003512.AE006468.3570463_3572006.3227	ariba	ariba_v1	97.22	rrsB+.l15.c17.ctg.1										765.7			1544						
+ariba_report	rrsD	rrsD.3003512.AE006468.3570463_3572006.3227	dbname	db_v_1	rrsD.3003512.AE006468.3570463_3572006.3227	ariba	ariba_v1	97.22	rrsB+.l15.c17.ctg.1										765.7			1544						
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diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_rgi.json
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_rgi.json	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,1 @@
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penam", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic inactivation"}, {"input_file_name": "rgi_report", "gene_symbol": "catB3", "gene_name": "chloramphenicol acetyltransferase (CAT)", "reference_database_id": "CARD", "reference_database_version": "card_v1", "reference_accession": "3002676", "analysis_software_name": "rgi", "analysis_software_version": "rgi_v1", "sequence_identity": "100.0", "input_sequence_id": "NODE_51_length_1731_cov_22.5767_2 ", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "1164", "input_gene_stop": "1712", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "+", "coverage_depth": "", "coverage_percentage": "86.67", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "phenicol antibiotic", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic inactivation"}, {"input_file_name": "rgi_report", "gene_symbol": "AAC(6')-Ib-cr", "gene_name": "AAC(6')", "reference_database_id": "CARD", "reference_database_version": "card_v1", "reference_accession": "3002547", "analysis_software_name": "rgi", "analysis_software_version": "rgi_v1", "sequence_identity": "95.45", "input_sequence_id": "NODE_54_length_1272_cov_25.1921_2 ", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "1130", "input_gene_stop": "1270", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "+", "coverage_depth": "", "coverage_percentage": "23.62", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "fluoroquinolone antibiotic; aminoglycoside antibiotic", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic inactivation"}, {"input_file_name": "rgi_report", "gene_symbol": "sul1", "gene_name": "sulfonamide resistant sul", "reference_database_id": "CARD", "reference_database_version": "card_v1", "reference_accession": "3000410", "analysis_software_name": "rgi", "analysis_software_version": "rgi_v1", "sequence_identity": "100.0", "input_sequence_id": "NODE_57_length_1134_cov_34.8908_1", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "25", "input_gene_stop": "864", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "-", "coverage_depth": "", "coverage_percentage": "100.0", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "sulfonamide antibiotic", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic target replacement"}, {"input_file_name": "rgi_report", "gene_symbol": "AAC(6')-Ib10", "gene_name": "AAC(6')", "reference_database_id": "CARD", "reference_database_version": "card_v1", "reference_accession": "3002581", "analysis_software_name": "rgi", "analysis_software_version": "rgi_v1", "sequence_identity": "100.0", "input_sequence_id": "NODE_69_length_625_cov_55.4398_1", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "63", "input_gene_stop": "623", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "-", "coverage_depth": "", "coverage_percentage": "91.63", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "aminoglycoside antibiotic", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic inactivation"}, {"input_file_name": "rgi_report", "gene_symbol": "AAC(6')-Ib-cr", "gene_name": "AAC(6')", "reference_database_id": "CARD", "reference_database_version": "card_v1", "reference_accession": "3002547", "analysis_software_name": "rgi", "analysis_software_version": "rgi_v1", "sequence_identity": "100.0", "input_sequence_id": "NODE_185_length_335_cov_33.8077_1 ", "input_protein_start": "", "input_protein_stop": "", "input_gene_start": "172", "input_gene_stop": "333", "reference_protein_start": "", "reference_protein_stop": "", "reference_gene_start": "", "reference_gene_stop": "", "strand_orientation": "+", "coverage_depth": "", "coverage_percentage": "27.14", "coverage_ratio": "", "reference_gene_length": "", "reference_protein_length": "", "input_gene_length": "", "input_protein_length": "", "drug_class": "fluoroquinolone antibiotic; aminoglycoside antibiotic", "antimicrobial_agent": "", "resistance_mechanism": "antibiotic inactivation"}]
diff -r 000000000000 -r d2590ecc4189 test-data/hamronized_rgi.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/hamronized_rgi.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,35 @@
+input_file_name	gene_symbol	gene_name	reference_database_id	reference_database_version	reference_accession	analysis_software_name	analysis_software_version	sequence_identity	input_sequence_id	input_protein_start	input_protein_stop	input_gene_start	input_gene_stop	reference_protein_start	reference_protein_stop	reference_gene_start	reference_gene_stop	strand_orientation	coverage_depth	coverage_percentage	coverage_ratio	reference_gene_length	reference_protein_length	input_gene_length	input_protein_length	drug_class	antimicrobial_agent	resistance_mechanism
+rgi_report	oqxA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003922	rgi	rgi_v1	100.0	NODE_1_length_803036_cov_42.265_33			30758	31933					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	oqxB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003923	rgi	rgi_v1	99.52	NODE_1_length_803036_cov_42.265_34			31957	35109					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	emrR	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3000516	rgi	rgi_v1	92.57	NODE_1_length_803036_cov_42.265_80			79380	79910					+		100.0						fluoroquinolone antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnG	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004588	rgi	rgi_v1	99.74	NODE_1_length_803036_cov_42.265_81			80036	81208					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnH	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004597	rgi	rgi_v1	94.02	NODE_1_length_803036_cov_42.265_82			81224	82762					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	mdtB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000793	rgi	rgi_v1	90.1	NODE_3_length_454317_cov_40.2449_14			17656	20778					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	mdtC	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000794	rgi	rgi_v1	91.41	NODE_3_length_454317_cov_40.2449_15			20779	23856					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	baeR	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000828	rgi	rgi_v1	90.83	NODE_3_length_454317_cov_40.2449_18			26745	27467					+		100.0						aminoglycoside antibiotic; aminocoumarin antibiotic		antibiotic efflux
+rgi_report	acrD	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000491	rgi	rgi_v1	90.94	NODE_3_length_454317_cov_40.2449_285			330238	333351					+		100.0						aminoglycoside antibiotic		antibiotic efflux
+rgi_report	FosA6	fosfomycin thiol transferase	CARD	card_v1	3004111	rgi	rgi_v1	97.84	NODE_4_length_367278_cov_42.3139_12			14037	14456					+		100.0						fosfomycin		antibiotic inactivation
+rgi_report	Klebsiella pneumoniae acrA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3004041	rgi	rgi_v1	95.24	NODE_6_length_262587_cov_42.4347_106 			86156	87349					+		99.75						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	acrB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000216	rgi	rgi_v1	91.52	NODE_6_length_262587_cov_42.4347_107			87372	90518					+		99.9						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	Escherichia coli ampH beta-lactamase	ampC-type beta-lactamase	CARD	card_v1	3004612	rgi	rgi_v1	85.71	NODE_6_length_262587_cov_42.4347_234			216120	217280					+		100.26						cephalosporin; penam		antibiotic inactivation
+rgi_report	msbA	ATP-binding cassette (ABC) antibiotic efflux pump	CARD	card_v1	3003950	rgi	rgi_v1	92.78	NODE_8_length_247415_cov_40.5207_219			227800	229548					-		100.0						nitroimidazole antibiotic		antibiotic efflux
+rgi_report	CRP	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000518	rgi	rgi_v1	99.05	NODE_9_length_203843_cov_42.4911_20			15303	15935					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; penam		antibiotic efflux
+rgi_report	PmrF	pmr phosphoethanolamine transferase	CARD	card_v1	3003578	rgi	rgi_v1	83.69	NODE_9_length_203843_cov_42.4911_123			130217	131200					-		101.55						peptide antibiotic		antibiotic target alteration
+rgi_report	marA	resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams	CARD	card_v1	3000263	rgi	rgi_v1	92.74	NODE_11_length_157792_cov_39.2115_112			108413	108787					+		97.64						fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan; penem		antibiotic efflux; reduced permeability to antibiotic
+rgi_report	SHV-11	SHV beta-lactamase	CARD	card_v1	3001070	rgi	rgi_v1	100.0	NODE_11_length_157792_cov_39.2115_132			128890	129750					+		100.0						carbapenem; cephalosporin; penam		antibiotic inactivation
+rgi_report	CBP-1	CBP beta-lactamase	CARD	card_v1	3004764	rgi	rgi_v1	100.0	NODE_19_length_86672_cov_43.8582_38 			39587	39811					-		24.03						penam		antibiotic inactivation
+rgi_report	Escherichia coli mdfA	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3001328	rgi	rgi_v1	85.61	NODE_21_length_66123_cov_41.3566_52			60858	62090					+		100.0						tetracycline antibiotic; benzalkonium chloride; rhodamine		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnE	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004580	rgi	rgi_v1	99.17	NODE_27_length_37761_cov_37.6839_21			25311	25673					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnF	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004583	rgi	rgi_v1	100.0	NODE_27_length_37761_cov_37.6839_22			25660	25989					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	AAC(3)-IId	AAC(3)	CARD	card_v1	3004623	rgi	rgi_v1	100.0	NODE_39_length_11164_cov_23.0187_6			4569	5429					+		100.0						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	rmtC	16S rRNA methyltransferase (G1405)	CARD	card_v1	3000861	rgi	rgi_v1	100.0	NODE_40_length_7360_cov_24.8738_6			6358	7203					-		100.0						aminoglycoside antibiotic		antibiotic target alteration
+rgi_report	NDM-1	NDM beta-lactamase	CARD	card_v1	3000589	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_1			301	1113					+		100.0						carbapenem; cephalosporin; cephamycin; penam		antibiotic inactivation
+rgi_report	BRP(MBL)	Bleomycin resistant protein	CARD	card_v1	3001205	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_2 			1222	1482					+		71.07						glycopeptide antibiotic		antibiotic inactivation
+rgi_report	DHA-7	DHA beta-lactamase	CARD	card_v1	3002136	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_3 			1846	2862					-		89.18						cephalosporin; cephamycin		antibiotic inactivation
+rgi_report	CTX-M-15	CTX-M beta-lactamase	CARD	card_v1	3001878	rgi	rgi_v1	100.0	NODE_47_length_3813_cov_27.9457_4			2763	3638					-		100.0						cephalosporin		antibiotic inactivation
+rgi_report	OXA-1	OXA beta-lactamase	CARD	card_v1	3001396	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_1			196	1026					+		100.0						cephalosporin; penam		antibiotic inactivation
+rgi_report	catB3	chloramphenicol acetyltransferase (CAT)	CARD	card_v1	3002676	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_2 			1164	1712					+		86.67						phenicol antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	95.45	NODE_54_length_1272_cov_25.1921_2 			1130	1270					+		23.62						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	sul1	sulfonamide resistant sul	CARD	card_v1	3000410	rgi	rgi_v1	100.0	NODE_57_length_1134_cov_34.8908_1			25	864					-		100.0						sulfonamide antibiotic		antibiotic target replacement
+rgi_report	AAC(6')-Ib10	AAC(6')	CARD	card_v1	3002581	rgi	rgi_v1	100.0	NODE_69_length_625_cov_55.4398_1			63	623					-		91.63						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	100.0	NODE_185_length_335_cov_33.8077_1 			172	333					+		27.14						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
diff -r 000000000000 -r d2590ecc4189 test-data/rgi/rgi.json
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/rgi/rgi.json	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,1 @@
+{"NODE_1_length_803036_cov_42.265_33 # 30758 # 31933 # 1 # ID=1_33;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.599": {"gnl|BL_ORD_ID|2216|hsp_num:0": {"type_match": "Perfect", "model_id": "2399", "orf_strand": "+", "orf_start": 30758, "orf_end": 31933, "orf_from": "NODE_1_length_803036_cov_42.265_33", "model_name": "oqxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "ARO_accession": "3003922", "ARO_name": "oqxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 798.119, "max_identities": 391, "cvterm_id": "35914", "query": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "match": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "sequence_from_db": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "sequence_from_broadstreet": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "dna_sequence_from_broadstreet": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCACAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACTGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTCGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAAAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTGGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "partial": "0", "query_start": 30758, "query_end": 31930, "orf_dna_sequence": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCGCAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACCGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTGGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAGAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTTGGCGAGGAAGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACACCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCTGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACTGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "orf_prot_sequence": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "perc_identity": 100.0}}, "NODE_1_length_803036_cov_42.265_34 # 31957 # 35109 # 1 # ID=1_34;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.612": {"gnl|BL_ORD_ID|2217|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 31957, "orf_end": 35109, "orf_from": "NODE_1_length_803036_cov_42.265_34", "model_name": "oqxB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2400", "pass_evalue": "n/a", "pass_bitscore": "2000", "ARO_accession": "3003923", "ARO_name": "oqxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 2107.8, "max_identities": 1045, "cvterm_id": "35914", "query": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "match": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSP GKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLV KTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLT+LFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGP+RESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDL A", "sequence_from_db": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA", "sequence_from_broadstreet": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA", "dna_sequence_from_broadstreet": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTCTCCCCCGGCGGGAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCTGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGTTGATCGCTGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGCCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGACTGGTAGGCAAAACGCTTGGACGCCGTGGCGCAGTGTTTGCGGTGTACCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATCAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTTTCCATCCTGCCGCCGCCGATTTTAGGTCTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGATCTGTTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCTGACGGACCATACCGCGAGAGCGTGGAAGATATCGCCAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTACCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAAGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCATTCCTCGTACTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCATGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTGTTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTACGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCCCGCCTAG", "partial": "0", "query_start": 31957, "query_end": 35106, "orf_dna_sequence": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTTTCGCCAAACGGTAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCGGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGCTGATCGCGGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGTCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGGCTGGTGAGCAAAACCCTCGGACGCCGTGGCGCGGTGTTTGCGGTGTATCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATTAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTCTCCATCCTGCCGCCGCCGATTTTAGGACTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGAGCTATTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCCGATGGGCCATTCCGCGAGAGCGTGGAAGATATTGCTAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTGCCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAGGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCGTTCCTCGTGCTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCGTGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTATTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTGCGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCTCGCCTAG", "orf_prot_sequence": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "perc_identity": 99.52}, "gnl|BL_ORD_ID|137|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 31957, "orf_end": 35109, "orf_from": "NODE_1_length_803036_cov_42.265_34", "model_name": "adeF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "153", "pass_evalue": "n/a", "pass_bitscore": "750", "ARO_accession": "3000777", "ARO_name": "adeF", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1208.74, "max_identities": 639, "cvterm_id": "35535", "query": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKH---TAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRK", "match": "M+ S+FFIDRPIFA VLS+LI + GL+++  LP+SEYP+VVPPSV VRA+YPGANPKVIAETVA+PLEE+INGVE+M+YM+S A SDG L  TV F+ G DPD+AQ  VQNRV+QA  RLPEDV+RLG+TT K SPTLT+VVHL SP+ +YD  Y+RNYA L VKD LARL GVG++ +FGSG+YAMRVWLDP KVA R LTA+++V A++EQN+QV+AG +GA P    S   +S+NAQGRL TE+EF +IILKTA DG++ RL DVAR+E+ +  Y LRS L+NK AV I IFQ+PGANA+ +S+ VR+ M EL+  FP  +++   YDPT FVR SI+AVV TLLEA+ LVV+VVILFLQTWRASIIPL+AVPVS++GTF+++   G+S+N LSLFG+VLAIGIVVDDAIVVVENVERNIE GL P  A ++AMREVSGPIIAIAL L AVFVP+AF++G+TGQFYKQFA+TIAISTVISA NSLTLSPALAALLLK H AK D  TR+++R+FG  F  FNR F R+S+ Y   VS+ +  + +   VY  LL     +  +VPGGF+P QDK YLI   ++P G+SL RT+AVIRKMS+  +   GV+ AVAFPGL+   FTN+ + G VF  LKPFD+RK    +A  I   +N K + IQ  +     PPP++GLG   G+ L ++DRG LGY AL  A      A    P +    S+YQ NVPQL+V +DR KAK QGV++T++F T+Q YLGS YVNDFN+FGR ++V AQAD PFR + EDI  L+TRN+ G+MVP+ S+VN++ TYGP+ V+RYNGY +AD+ G   P   SSSQA   +E ++ Q LP G+  EWTDL++Q+   GN  L VFP++VLL FLVLAA YES TLPLAVILIVPM +L+AL GVWLT GDNN+F Q+GL+VL+GLACKNAILIVEFARELE+QG    +AA+EA RLRLRPI+MTSIAFI G +PL+   GAG+E+R   G+ VF GM+GVT FGLFLTP FYV +R L ++ K", "sequence_from_db": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASP--SNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPG-YSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHK", "sequence_from_broadstreet": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH", "dna_sequence_from_broadstreet": "ATGAATATTTCTAAATTTTTTATTGATCGGCCGATCTTTGCTGGTGTGCTATCAGTCTTGATTTTACTCGCCGGTCTCCTTTCGGTATTTCAGTTACCGATTTCTGAATATCCCGAGGTTGTTCCACCATCTGTGGTGGTACGCGCCCAATATCCGGGTGCAAACCCAAAAGTGATTGCTGAAACGGTTGCATCTCCGCTCGAAGAGTCAATCAACGGCGTCGAAGACATGCTGTATATGCAATCTCAAGCAAACAGCGACGGTAACCTAACCATTACGGTGAACTTTAAGCTCGGTATCGACCCAGACAAAGCCCAACAATTGGTTCAAAACCGTGTGTCTCAGGCCATGCCCCGTTTACCTGAAGATGTACAGCGCTTAGGTGTAACCACACTAAAAAGCTCACCTACTTTAACTATGGTAGTGCATCTGACCTCACCAGATAATCGCTATGACATGACCTACTTACGTAACTATGCGGTGCTCAACGTGAAAGACCGTTTAGCGCGTTTACAAGGGGTTGGTGAAGTCGGATTATTTGGTTCTGGTGACTACGCGATGCGTGTATGGCTTGACCCGCAAAAAGTAGCGCAGCGTAACCTCACCGCGACCGAAATTGTGAATGCAATCCGTGAACAAAATATTCAGGTTGCAGCGGGTACAATCGGTGCATCACCAAGTAATTCACCTTTACAGCTTTCAGTCAATGCTCAAGGTCGTTTAACTACTGAACAAGAATTCGCAGATATCATTTTAAAAACTGCACCAGATGGCGCGGTTACCCGATTGGGTGATGTTGCTCGTGTCGAACTTGCAGCCTCTCAATATGGCTTACGTTCATTGCTTGATAATAAACAAGCGGTCGCGATTCCAATTTTCCAAGCACCGGGTGCGAATGCTTTACAAGTTTCCGATCAAGTGCGTAGCACAATGAAGGAGCTTTCAAAAGATTTCCCATCTTCAATTAAATACGACATTGTTTATGACCCGACTCAATTCGTACGTGCAAGTATTAAAGCGGTCGTTCATACCTTACTTGAAGCAATTACACTGGTTGTTGTGGTCGTTATTTTATTCTTGCAAACATGGCGTGCCTCAATCATTCCATTGCTTGCCGTACCGGTTTCAATTATTGGTACATTCGCGCTCATGCTCGCTTTTGGTTACTCAATCAATGCGCTATCACTGTTCGGAATGGTACTTGCCATCGGGATTGTCGTCGATGACGCGATTGTGGTCGTCGAAAATGTCGAGAGGAATATTGAAGCAGGCTTAAACCCAAGGGAGGCGACTTACCGTGCCATGCGAGAAGTCAGTGGACCGATTATTGCCATTGCTTTAACACTTGTTGCAGTATTCGTACCTCTTGCCTTTATGACAGGCTTAACAGGGCAATTCTATAAACAATTTGCCATGACCATTGCCATTTCAACGGTTATTTCGGCATTTAACTCGCTTACCCTATCTCCTGCTTTGGCAGCGCTGTTACTGAAAGGACATGATGCTAAACCGGATGCCTTAACACGTATTATGAATCGTGTATTCGGTCGTTTCTTTGCACTGTTTAACCGTGTGTTTTCACGTGCTTCAGACCGTTATAGTCAAGGCGTCAGCCGTGTCATTTCCCATAAAGCTTCGGCAATGGGTGTCTATGCAGCACTCTTAGGTTTAACCGTTGGTATTTCCTATATTGTTCCAGGTGGTTTCGTTCCTGCGCAGGACAAACAATATTTAATTAGCTTTGCGCAGCTACCAAACGGCGCATCATTAGATCGTACCGAAGCGGTCATTCGTAAAATGAGTGACACTGCACTTAAACAACCTGGTGTAGAAAGTGCAGTTGCCTTTCCTGGCCTATCAATTAACGGTTTCACCAATAGCTCAAGTGCCGGTATTGTCTTTGTGACTTTAAAGCCATTTGATGAACGTAAGGCAAAAGACTTATCTGCAAATGCAATTGCAGGTGCGCTCAACCAGAAATATTCAGCTATTCAAGATGCCTATATCGCGGTTTTCCCACCGCCACCAGTGATGGGCTTAGGTACTATGGGCGGCTTTAAACTACAACTTGAAGACCGAGGTGCCTTAGGCTATTCAGCCTTGAACGATGCTGCACAAAACTTTATGAAGGCAGCACAATCAGCCCCTGAACTGGGTCCAATGTTCTCAAGTTATCAAATTAACGTACCTCAACTCAACGTAGATCTGGACCGTGTAAAAGCTAAACAGCAAGGCGTTGCTGTGACAGATGTTTTCAATACTATGCAGATTTATTTAGGTTCTCAGTACGTTAACGACTTTAACCGCTTTGGACGTGTTTATCAGGTTCGTGCACAAGCCGATGCGCCTTTCCGTGCTAACCCTGAAGATATTTTGCAGCTTAAAACCCGTAATAGTGCCGGACAAATGGTGCCATTATCTTCATTGGTGAATGTAACTCAAACCTATGGTCCTGAAATGGTCGTTCGTTATAACGGTTACACATCAGCAGATATTAACGGTGGCCCTGCCCCAGGTTATTCATCTAGCCAAGCAGAAGCTGCGGTTGAACGTATTGCTGCACAAACTCTACCGCGTGGTATCAAGTTTGAATGGACAGATTTAACTTATCAAAAAATCTTGGCTGGTAATGCTGGACTTTGGGTATTCCCTATTAGCGTATTACTCGTGTTCTTAGTGTTAGCTGCTCAGTATGAAAGCTTAACCCTACCATTAGCAGTTATCTTAATTGTACCAATGGGAATCTTAGCGGCTCTGACAGGTGTCTGGTTGACAGCTGGAGATAACAACATCTTTACTCAAATCGGTCTAATGGTACTGGTCGGGCTAGCCTGTAAAAATGCCATCTTAATTGTCGAATTTGCGAGGGAACTTGAAATGCAAGGTGCGACTGCCTTTAAAGCAGCCGTTGAAGCAAGTCGTCTACGTTTACGCCCAATTTTAATGACCTCTATTGCATTTATTATGGGTGTAGTGCCACTGGTTACTTCAACTGGCGCAGGTTCTGAAATGCGACATGCGATGGGTGTTGCCGTATTCTTCGGTATGATCGGTGTAACATTCTTTGGTTTATTCCTCACCCCGGCCTTTTACGTTCTGATTCGTACCCTCAACAGCAAACATAAACTGCATTCTGCGGCAGTTCATGAAGCGCCGTTAGCTAGCCCACATGATCATTAA", "partial": "0", "query_start": 31957, "query_end": 35082, "orf_dna_sequence": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTTTCGCCAAACGGTAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCGGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGCTGATCGCGGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGTCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGGCTGGTGAGCAAAACCCTCGGACGCCGTGGCGCGGTGTTTGCGGTGTATCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATTAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTCTCCATCCTGCCGCCGCCGATTTTAGGACTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGAGCTATTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCCGATGGGCCATTCCGCGAGAGCGTGGAAGATATTGCTAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTGCCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAGGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCGTTCCTCGTGCTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCGTGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTATTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTGCGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCTCGCCTAG", "orf_prot_sequence": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "perc_identity": 61.15}}, "NODE_1_length_803036_cov_42.265_80 # 79380 # 79910 # 1 # ID=1_80;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.520": {"gnl|BL_ORD_ID|1251|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 79380, "orf_end": 79910, "orf_from": "NODE_1_length_803036_cov_42.265_80", "model_name": "emrR", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1330", "pass_evalue": "n/a", "pass_bitscore": "280", "ARO_accession": "3000516", "ARO_name": "emrR", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.09906e-122, "bit_score": 338.961, "max_identities": 162, "cvterm_id": "36849", "query": "MDSSFTPIEQMLKFRASRHEDFPFQEILLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHQFLREVLPPQHNCLHQLWSSLSTSEKDQLEHITRKLLSRLDQMEEEGVLADSL", "match": "MDSSFTPIEQMLKFRASRHEDFP+QEILLTRLCMHMQ KLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGH+FLREVLPPQHNCLHQLWS+LST+EKDQLE ITRKLLSRLDQME++GV+ +++", "sequence_from_db": "MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAM", "sequence_from_broadstreet": "MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS", "dna_sequence_from_broadstreet": "ATGGATAGTTCGTTTACGCCCATTGAACAAATGCTAAAATTTCGCGCCAGCCGCCACGAAGATTTTCCTTATCAGGAGATCCTTCTGACTCGTCTTTGCATGCACATGCAAAGCAAGCTGCTGGAGAACCGCAATAAAATGCTGAAGGCTCAGGGGATTAACGAGACGTTGTTTATGGCGTTGATTACGCTGGAGTCTCAGGAAAACCACAGTATTCAGCCTTCTGAATTAAGTTGTGCTCTTGGATCATCCCGTACCAACGCGACGCGTATTGCCGATGAACTGGAAAAACGCGGTTGGATCGAACGTCGTGAAAGCGATAACGATCGCCGCTGCCTGCATCTGCAATTAACGGAAAAAGGTCACGAGTTTTTGCGCGAGGTTTTACCACCGCAGCATAACTGCCTGCATCAACTCTGGTCCGCGCTCAGCACAACAGAAAAAGATCAGCTCGAGCAAATCACCCGCAAATTGCTCTCCCGTCTCGACCAGATGGAACAAGACGGTGTGGTTCTCGAAGCGATGAGCTAA", "partial": "0", "query_start": 79380, "query_end": 79904, "orf_dna_sequence": "ATGGATAGTTCGTTTACTCCCATTGAGCAAATGCTCAAGTTCCGCGCCAGCCGCCATGAAGATTTCCCGTTTCAGGAGATCCTGTTAACTCGTCTTTGCATGCATATGCAAGGTAAGCTGCTGGAAAATCGCAATAAAATGCTCAAAGCGCAGGGAATTAACGAGACATTATTTATGGCGCTGATTACGCTGGAGTCACAGGAAAACCACAGCATCCAGCCGTCCGAGCTGAGCTGTGCGCTGGGCTCGTCACGTACCAACGCCACCCGTATCGCTGATGAACTGGAAAAACGCGGCTGGATTGAGCGCCGCGAGAGCGATAACGATCGTCGCTGTTTGCATCTGCAACTGACCGAAAAGGGCCATCAGTTTTTGCGTGAAGTCCTGCCGCCGCAGCATAACTGCCTGCATCAGCTGTGGTCTTCACTTAGCACCAGCGAAAAAGATCAGCTCGAACACATCACCCGCAAACTCCTGAGCCGCCTTGATCAGATGGAAGAAGAAGGCGTGCTAGCGGACTCTCTACGCTAA", "orf_prot_sequence": "MDSSFTPIEQMLKFRASRHEDFPFQEILLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHQFLREVLPPQHNCLHQLWSSLSTSEKDQLEHITRKLLSRLDQMEEEGVLADSLR", "perc_identity": 92.57}}, "NODE_1_length_803036_cov_42.265_81 # 80036 # 81208 # 1 # ID=1_81;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.594": {"gnl|BL_ORD_ID|2786|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 80036, "orf_end": 81208, "orf_from": "NODE_1_length_803036_cov_42.265_81", "model_name": "Klebsiella pneumoniae KpnG", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3298", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3004588", "ARO_name": "Klebsiella pneumoniae KpnG", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 788.875, "max_identities": 389, "cvterm_id": "42597", "query": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "match": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTAL+QAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "sequence_from_db": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "sequence_from_broadstreet": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "dna_sequence_from_broadstreet": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACTCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTCCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCTCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACTGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATCGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGTACCGGCAGCGCCTTCTCCCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGCCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "partial": "0", "query_start": 80036, "query_end": 81205, "orf_dna_sequence": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACGCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTGCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCGCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACCGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATTGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGCACCGGCAGCGCCTTCTCTCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGTCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "orf_prot_sequence": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "perc_identity": 99.74}}, "NODE_1_length_803036_cov_42.265_82 # 81224 # 82762 # 1 # ID=1_82;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=3-4bp;gc_cont=0.612": {"gnl|BL_ORD_ID|2787|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 81224, "orf_end": 82762, "orf_from": "NODE_1_length_803036_cov_42.265_82", "model_name": "Klebsiella pneumoniae KpnH", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3299", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3004597", "ARO_name": "Klebsiella pneumoniae KpnH", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 937.947, "max_identities": 472, "cvterm_id": "42596", "query": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPF", "match": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIP+TGWLAKRVGEVKLFLWST AFAIASWACGVS+SL MLIFFRVIQGIVAGPLIPLSQSLLL+NYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLR RET+TE+RRID VGLALL+IGIGSLQ+MLDRGKELDWFSS EIIILT+VAVVAI FLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVG+IPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRA+TFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT+WTNRE++HHAQLTESV PFNPNAQ +Y QL+G+GMTQQQASGWIAQQITNQGLIISANEIFW+SA IF++LLGLVWFA+PPF", "sequence_from_db": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPF", "sequence_from_broadstreet": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPFGAGGGGGGAH", "dna_sequence_from_broadstreet": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAACTGGTCATTATGACGATTGCGCTGTCACTGGCGACATTCATGCAGGTGCTGGACTCCACCATTGCTAACGTGGCGATCCCCACTATCGCCGGGAATCTGGGCTCATCGCTCAGCCAGGGAACGTGGGTAATCACTTCTTTCGGGGTGGCGAATGCCATCTCGATCCCGCTTACCGGCTGGCTGGCAAAGCGCGTCGGGGAAGTGAAACTGTTCCTTTGGTCCACCATCGCCTTTGCTATTGCGTCGTGGGCGTGTGGTGTCTCCAGCAGCCTGAATATGCTGATCTTCTTCCGCGTGATTCAGGGGATTGTCGCCGGGCCGTTGATCCCGCTTTCGCAAAGTCTATTGCTGAATAACTACCCGCCAGCCAAACGCTCGATCGCGCTGGCGTTGTGGTCGATGACGGTGATTGTCGCGCCAATTTGCGGCCCGATCCTCGGCGGTTATATCAGCGATAATTACCACTGGGGCTGGATATTCTTCATCAACGTGCCGATTGGCGTGGCGGTGGTGTTGATGACACTGCAAACTCTGCGCGGACGTGAAACCCGCACCGAACGGCGGCGGATTGATGCCGTGGGGCTGGCACTGCTGGTTATTGGTATCGGCAGCCTGCAGATTATGCTCGACCGCGGTAAAGAGCTGGACTGGTTTTCATCACAGGAAATTATCATCCTTACCGTGGTGGCGGTGGTGGCTATCTGCTTCCTGATTGTCTGGGAGCTGACCGACGATAACCCGATAGTCGATCTGTCGTTGTTTAAGTCGCGCAACTTCACCATCGGCTGCTTGTGTATCAGCCTCGCGTATATGCTCTACTTCGGCGCTATTGTTCTGCTGCCGCAGTTGTTGCAGGAGGTCTACGGTTACACGGCGACCTGGGCAGGTTTGGCCTCTGCGCCGGTAGGGATTATTCCGGTGATCCTGTCGCCGATTATCGGCCGCTTCGCGCATAAACTGGATATGCGGCGGCTGGTAACCTTCAGCTTTATTATGTATGCCGTCTGCTTCTACTGGCGTGCCTATACCTTTGAACCAGGTATGGATTTTGGCGCGTCGGCCTGGCCGCAGTTTATCCAGGGGTTTGCGGTGGCCTGCTTCTTTATGCCGCTGACCACCATTACGCTGTCTGGTTTGCCACCGGAACGACTGGCGGCGGCATCGAGCCTCTCTAACTTTACGCGAACGCTGGCGGGGTCTATCGGCACGTCGATAACCACGACCATGTGGACCAACCGCGAGTCGATGCACCATGCGCAGTTGACTGAGTCGGTAAACCCGTTCAACCCGAATGCCCAGGCGATGTACAGTCAACTGGAAGGGCTTGGGATGACGCAACAGCAGGCATCAGGCTGGATTGCCCAGCAGATCACCAATCAGGGGCTGATTATTTCCGCCAATGAGATCTTCTGGATGTCAGCCGGGATATTCCTCATCCTGCTGGGGCTGGTGTGGTTTGCTAAACCGCCATTTGGCGCAGGTGGCGGCGGAGGCGGTGCGCACTAA", "partial": "0", "query_start": 81224, "query_end": 82729, "orf_dna_sequence": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGCGACGTTCATGCAGGTGCTGGATTCCACTATCGCCAACGTGGCGATCCCGACCATTGCCGGCAACCTTGGCTCGTCGCTGAGCCAGGGGACCTGGGTCATCACCTCGTTCGGGGTCGCTAACGCCATCTCCATCCCGATCACCGGCTGGCTGGCCAAGCGCGTCGGCGAGGTGAAGCTGTTCCTGTGGTCAACCACCGCCTTCGCCATTGCCTCCTGGGCCTGCGGCGTCTCCAACAGCCTGACGATGCTGATTTTCTTCCGCGTCATTCAGGGGATCGTCGCCGGACCGCTGATCCCGCTGTCGCAAAGTCTGCTGCTCAGCAACTATCCCCCGGCGAAGCGCTCTATCGCTCTGGCGCTGTGGTCAATGACGGTGATTGTCGCGCCCATCTGCGGTCCGATCCTCGGCGGCTATATCAGCGATAACTATCACTGGGGCTGGATCTTCTTTATCAACGTGCCCATTGGCGTGGCGGTGGTGCTGATGACCCTGCAGACCCTGCGCAACCGGGAAACCAAAACCGAACAGCGGCGGATCGACGGTGTCGGTCTGGCGCTGCTGATCATCGGTATCGGTAGCCTGCAGGTGATGCTGGACCGGGGTAAAGAGCTGGACTGGTTCTCCTCCAATGAGATTATCATTCTGACCATCGTGGCGGTGGTGGCGATAAGCTTCCTGATCGTCTGGGAGCTAACCGACGATAACCCGATTGTCGATCTGTCGCTATTTAAGTCGCGCAACTTCACCATCGGCTGCCTCTGTATCAGTCTGGCCTATATGCTCTACTTCGGCGCCATCGTGCTGCTGCCGCAGCTGTTGCAGGAGGTCTACGGTTACACCGCGACCTGGGCCGGCCTGGCGTCGGCGCCGGTGGGGGTGATCCCGGTCATTCTGTCGCCGATTATCGGCCGCTTCGCGCATAAGCTCGACATGCGGCGGCTGGTCACCTTCAGCTTTATTATGTACGCGGTCTGCTTCTACTGGCGCGCCTGGACCTTCGAACCGGGGATGGACTTTGGCGCCTCGGCGTGGCCACAGTTTATCCAGGGCTTCGCGGTGGCCTGCTTCTTCATGCCGTTGACCACCATCACCCTCTCCGGCCTGCCGCCGGAGCGGCTGGCGGCGGCGTCGAGCCTGTCGAACTTCACCCGTACCCTTGCCGGCTCCATCGGGACCTCGATCACCACCACCCTGTGGACCAACCGCGAGGCGCTGCATCATGCGCAGCTCACCGAATCGGTGACCCCCTTTAACCCCAACGCGCAGCAGATATACGATCAGCTGCAGGGCATGGGAATGACGCAGCAGCAGGCGTCCGGCTGGATAGCGCAGCAGATAACCAACCAGGGGCTGATTATCTCCGCCAACGAAATCTTCTGGATTTCTGCGGCTATTTTCATCCTGCTGTTGGGGCTGGTGTGGTTCGCCAGACCACCGTTCAGCGCCGGCGGAGGCGGCGGCGGCGCGCACTAG", "orf_prot_sequence": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPFSAGGGGGGAH", "perc_identity": 94.02}, "gnl|BL_ORD_ID|1745|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 81224, "orf_end": 82762, "orf_from": "NODE_1_length_803036_cov_42.265_82", "model_name": "emrB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1847", "pass_evalue": "n/a", "pass_bitscore": "900", "ARO_accession": "3000074", "ARO_name": "emrB", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 937.947, "max_identities": 472, "cvterm_id": "36849", "query": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPF", "match": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIP+TGWLAKRVGEVKLFLWST AFAIASWACGVS+SL MLIFFRVIQGIVAGPLIPLSQSLLL+NYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLR RET+TE+RRID VGLALL+IGIGSLQ+MLDRGKELDWFSS EIIILT+VAVVAI FLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVG+IPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRA+TFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT+WTNRE++HHAQLTESV PFNPNAQ +Y QL+G+GMTQQQASGWIAQQITNQGLIISANEIFW+SA IF++LLGLVWFA+PPF", "sequence_from_db": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPF", "sequence_from_broadstreet": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPFGAGGGGGGAH", "dna_sequence_from_broadstreet": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAACTGGTCATTATGACGATTGCGCTGTCACTGGCGACATTCATGCAGGTGCTGGACTCCACCATTGCTAACGTGGCGATCCCCACTATCGCCGGGAATCTGGGCTCATCGCTCAGCCAGGGAACGTGGGTAATCACTTCTTTCGGGGTGGCGAATGCCATCTCGATCCCGCTTACCGGCTGGCTGGCAAAGCGCGTCGGGGAAGTGAAACTGTTCCTTTGGTCCACCATCGCCTTTGCTATTGCGTCGTGGGCGTGTGGTGTCTCCAGCAGCCTGAATATGCTGATCTTCTTCCGCGTGATTCAGGGGATTGTCGCCGGGCCGTTGATCCCGCTTTCGCAAAGTCTATTGCTGAATAACTACCCGCCAGCCAAACGCTCGATCGCGCTGGCGTTGTGGTCGATGACGGTGATTGTCGCGCCAATTTGCGGCCCGATCCTCGGCGGTTATATCAGCGATAATTACCACTGGGGCTGGATATTCTTCATCAACGTGCCGATTGGCGTGGCGGTGGTGTTGATGACACTGCAAACTCTGCGCGGACGTGAAACCCGCACCGAACGGCGGCGGATTGATGCCGTGGGGCTGGCACTGCTGGTTATTGGTATCGGCAGCCTGCAGATTATGCTCGACCGCGGTAAAGAGCTGGACTGGTTTTCATCACAGGAAATTATCATCCTTACCGTGGTGGCGGTGGTGGCTATCTGCTTCCTGATTGTCTGGGAGCTGACCGACGATAACCCGATAGTCGATCTGTCGTTGTTTAAGTCGCGCAACTTCACCATCGGCTGCTTGTGTATCAGCCTCGCGTATATGCTCTACTTCGGCGCTATTGTTCTGCTGCCGCAGTTGTTGCAGGAGGTCTACGGTTACACGGCGACCTGGGCAGGTTTGGCCTCTGCGCCGGTAGGGATTATTCCGGTGATCCTGTCGCCGATTATCGGCCGCTTCGCGCATAAACTGGATATGCGGCGGCTGGTAACCTTCAGCTTTATTATGTATGCCGTCTGCTTCTACTGGCGTGCCTATACCTTTGAACCAGGTATGGATTTTGGCGCGTCGGCCTGGCCGCAGTTTATCCAGGGGTTTGCGGTGGCCTGCTTCTTTATGCCGCTGACCACCATTACGCTGTCTGGTTTGCCACCGGAACGACTGGCGGCGGCATCGAGCCTCTCTAACTTTACGCGAACGCTGGCGGGGTCTATCGGCACGTCGATAACCACGACCATGTGGACCAACCGCGAGTCGATGCACCATGCGCAGTTGACTGAGTCGGTAAACCCGTTCAACCCGAATGCCCAGGCGATGTACAGTCAACTGGAAGGGCTTGGGATGACGCAACAGCAGGCATCAGGCTGGATTGCCCAGCAGATCACCAATCAGGGGCTGATTATTTCCGCCAATGAGATCTTCTGGATGTCAGCCGGGATATTCCTCGTCCTGCTGGGGCTGGTGTGGTTTGCTAAACCGCCATTTGGCGCAGGTGGCGGCGGAGGCGGTGCGCACTAA", "partial": "0", "query_start": 81224, "query_end": 82729, "orf_dna_sequence": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGCGACGTTCATGCAGGTGCTGGATTCCACTATCGCCAACGTGGCGATCCCGACCATTGCCGGCAACCTTGGCTCGTCGCTGAGCCAGGGGACCTGGGTCATCACCTCGTTCGGGGTCGCTAACGCCATCTCCATCCCGATCACCGGCTGGCTGGCCAAGCGCGTCGGCGAGGTGAAGCTGTTCCTGTGGTCAACCACCGCCTTCGCCATTGCCTCCTGGGCCTGCGGCGTCTCCAACAGCCTGACGATGCTGATTTTCTTCCGCGTCATTCAGGGGATCGTCGCCGGACCGCTGATCCCGCTGTCGCAAAGTCTGCTGCTCAGCAACTATCCCCCGGCGAAGCGCTCTATCGCTCTGGCGCTGTGGTCAATGACGGTGATTGTCGCGCCCATCTGCGGTCCGATCCTCGGCGGCTATATCAGCGATAACTATCACTGGGGCTGGATCTTCTTTATCAACGTGCCCATTGGCGTGGCGGTGGTGCTGATGACCCTGCAGACCCTGCGCAACCGGGAAACCAAAACCGAACAGCGGCGGATCGACGGTGTCGGTCTGGCGCTGCTGATCATCGGTATCGGTAGCCTGCAGGTGATGCTGGACCGGGGTAAAGAGCTGGACTGGTTCTCCTCCAATGAGATTATCATTCTGACCATCGTGGCGGTGGTGGCGATAAGCTTCCTGATCGTCTGGGAGCTAACCGACGATAACCCGATTGTCGATCTGTCGCTATTTAAGTCGCGCAACTTCACCATCGGCTGCCTCTGTATCAGTCTGGCCTATATGCTCTACTTCGGCGCCATCGTGCTGCTGCCGCAGCTGTTGCAGGAGGTCTACGGTTACACCGCGACCTGGGCCGGCCTGGCGTCGGCGCCGGTGGGGGTGATCCCGGTCATTCTGTCGCCGATTATCGGCCGCTTCGCGCATAAGCTCGACATGCGGCGGCTGGTCACCTTCAGCTTTATTATGTACGCGGTCTGCTTCTACTGGCGCGCCTGGACCTTCGAACCGGGGATGGACTTTGGCGCCTCGGCGTGGCCACAGTTTATCCAGGGCTTCGCGGTGGCCTGCTTCTTCATGCCGTTGACCACCATCACCCTCTCCGGCCTGCCGCCGGAGCGGCTGGCGGCGGCGTCGAGCCTGTCGAACTTCACCCGTACCCTTGCCGGCTCCATCGGGACCTCGATCACCACCACCCTGTGGACCAACCGCGAGGCGCTGCATCATGCGCAGCTCACCGAATCGGTGACCCCCTTTAACCCCAACGCGCAGCAGATATACGATCAGCTGCAGGGCATGGGAATGACGCAGCAGCAGGCGTCCGGCTGGATAGCGCAGCAGATAACCAACCAGGGGCTGATTATCTCCGCCAACGAAATCTTCTGGATTTCTGCGGCTATTTTCATCCTGCTGTTGGGGCTGGTGTGGTTCGCCAGACCACCGTTCAGCGCCGGCGGAGGCGGCGGCGGCGCGCACTAG", "orf_prot_sequence": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPFSAGGGGGGAH", "perc_identity": 94.02}}, "NODE_3_length_454317_cov_40.2449_14 # 17656 # 20778 # 1 # ID=3_14;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.646": {"gnl|BL_ORD_ID|774|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 17656, "orf_end": 20778, "orf_from": "NODE_3_length_454317_cov_40.2449_14", "model_name": "mdtB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "820", "pass_evalue": "n/a", "pass_bitscore": "1800", "ARO_accession": "3000793", "ARO_name": "mdtB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1835.85, "max_identities": 937, "cvterm_id": "36849", "query": "MQVLPPGRTGGPSRLFIMRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAIPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETVRTAITSANVNSAKGSLDGPARAVTLSANDQMQSAEDYRRLIIAYQNGAPIRLGDVASVEQGAENSWLGAWANQQRAIVMNVQRQPGANIIDTADSIRQMLPQLTESLPKSVKVQVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNVPATIIPGVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERFFERVIAVYGRWLSRVLNHPWLTLGVALSTLALSIILWVFIPKGFFPIQDNGIIQGTLQAPQSVSFASMAERQRQVASIILKDPAVESLTSFVGVDGTNPALNSARLQINLKPLDERDDRVQTVISRLQQAVDGVPGVALYLQPTQDLTIDTTVSRTQYQFTLQANSLEALSTWVPPLLSRLQAQPQLADVSSDWQDKGLAAYIKVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEQDTEATPGLAALENIRLTSSDGGIVPLTAIATVEQRFTPLSVNHLDQFPVTTISFNVPDNYSLGEAVEAILAAEQSLDFPTDIRTQFQGSSLAFQSALGSTVWLVVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALWLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMPPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLMLSQVLTLFTTPVIYLLFDRLSLHLKRRFPRQEEEA", "match": "MQVLPP  TGGPSRLFIMRPVATTLLMVAILLAGIIGYR LPVSALPEVDYPTIQVVTLYPGASPDV+TSA+TAPLERQFGQMSGLKQMSSQSSGGASV+TLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTS+A+PMTQVEDMVETRVAQKISQ+SGVGLVTL+GGQRPAVRVKLNAQAIAALGLTSETVRTAIT ANVNSAKGSLDGP+RAVTLSANDQMQSAE+YR+LIIAYQNGAPIRLGDVA+VEQGAENSWLGAWAN+++AIVMNVQRQPGANII TADSIRQMLPQLTESLPKSVKV VLSDRTTNIRASV DTQFELM+AIALVVMIIYLFLRN+PATIIPGVAVPLSL+GTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFA+TLAVAILISAVVSLTLTPMMCARMLS ESLRKQNRFSRASE+ F+R+IA YGR L++VLNHPWLTL VALSTL LS++LWVFIPKGFFP+QDNGIIQGTLQAPQS SFA+MA+RQRQVA +IL+DPAV+SLTSFVGVDGTNP+LNSARLQINLKPLDERDDRVQ VI+RLQ AVD VPGV L+LQPTQDLTIDT VSRTQYQFTLQA SL+ALSTWVP L+ +LQ  PQL+DVSSDWQDKGL AY+ VDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLE +TE TPGLAAL+ IRLTSSDGG+VPL++IA +EQRF PLS+NHLDQFPVTTISFNVPDNYSLG+AV+AI+  E++L+ P DI TQFQGS+LAFQSALGSTVWL+VAAVVAMYIVLG+LYESFIHPITILSTLPTAGVGALLAL +AGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGM PREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGL++SQVLTLFTTPVIYLLFDRL+L  K RF R EEEA", "sequence_from_db": "MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA", "sequence_from_broadstreet": "MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA", "dna_sequence_from_broadstreet": "ATGCAGGTGTTACCCCCGAGCAGCACAGGCGGCCCGTCGCGCCTGTTTATTATGCGTCCTGTGGCCACCACGCTGCTGATGGTGGCGATCTTACTCGCCGGGATTATCGGTTATCGCGCCCTGCCCGTTTCGGCGCTGCCGGAAGTGGACTATCCGACCATTCAGGTGGTCACGCTCTACCCAGGTGCCAGCCCGGATGTCATGACCTCTGCCGTTACCGCGCCGCTAGAACGCCAGTTCGGGCAGATGTCTGGCCTGAAACAGATGTCGTCGCAAAGTTCCGGCGGTGCGTCAGTTATCACTTTGCAGTTCCAGCTAACATTACCGCTCGATGTCGCCGAGCAGGAAGTGCAGGCCGCGATTAACGCTGCGACCAACTTGTTGCCGAGCGATCTGCCTAACCCGCCGGTTTACAGCAAAGTGAACCCGGCAGATCCGCCGATCATGACGCTCGCCGTCACCTCAACCGCCATGCCGATGACGCAAGTGGAAGATATGGTGGAAACCCGCGTCGCGCAGAAAATCTCGCAGATTTCCGGCGTCGGCCTGGTGACGCTTTCCGGCGGTCAGCGTCCGGCTGTTCGCGTCAAACTTAACGCTCAGGCGATTGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCCATTACCGGCGCTAACGTTAACTCGGCAAAAGGTAGCCTCGACGGCCCTTCCCGTGCGGTCACGCTTTCCGCGAACGACCAGATGCAATCCGCCGAAGAGTATCGCCAGCTAATCATCGCCTACCAGAACGGCGCGCCAATTCGTCTGGGCGATGTCGCAACTGTAGAGCAAGGTGCAGAAAACAGCTGGCTCGGCGCGTGGGCGAACAAAGAACAGGCCATTGTGATGAATGTTCAGCGCCAGCCCGGTGCTAACATTATCTCCACCGCCGACAGCATTCGGCAGATGCTGCCACAGCTCACTGAGAGTCTGCCGAAATCGGTGAAGGTGACAGTGCTTTCCGATCGCACCACCAATATCCGCGCATCCGTCGATGATACTCAGTTTGAATTGATGATGGCTATCGCGCTGGTAGTCATGATTATCTACCTGTTTTTGCGCAATATTCCGGCGACCATCATTCCCGGTGTTGCTGTACCGCTGTCGTTAATCGGCACTTTCGCGGTTATGGTGTTTCTCGATTTTTCAATCAATAACCTGACACTGATGGCGTTAACTATCGCCACCGGATTCGTGGTCGATGACGCCATCGTGGTGATCGAAAACATTTCCCGCTATATCGAAAAAGGCGAAAAACCGTTGGCGGCGGCGCTCAAGGGCGCAGGTGAAATCGGCTTTACCATTATCTCGCTGACCTTCTCACTGATTGCGGTGTTGATCCCACTGCTGTTTATGGGCGATATCGTCGGGCGACTGTTCCGCGAATTTGCTATTACCCTGGCGGTAGCGATTTTGATCTCAGCGGTGGTGTCGCTGACCCTGACACCGATGATGTGCGCGCGGATGCTCAGCCAGGAGTCGTTGCGTAAACAGAACCGCTTCTCCCGTGCCTCGGAAAAAATGTTCGACAGGATAATCGCCGCCTATGGTCGTGGACTGGCGAAAGTGCTGAATCATCCGTGGCTGACCTTAAGCGTGGCACTCAGCACGCTGCTGCTTAGCGTGCTGCTGTGGGTGTTCATTCCGAAAGGTTTCTTCCCGGTACAGGACAATGGCATTATTCAGGGCACTTTGCAGGCACCGCAATCCAGCTCCTTTGCCAATATGGCCCAGCGACAACGCCAGGTCGCGGACGTGATTTTGCAGGATCCGGCAGTGCAAAGCCTGACCTCATTTGTTGGCGTTGATGGCACTAACCCGTCGCTGAACAGTGCACGTTTACAAATCAACCTCAAACCGTTGGATGAACGTGATGATCGGGTGCAAAAAGTCATCGCCCGTCTGCAAACGGCGGTAGATAAAGTGCCGGGCGTCGATCTCTTCCTGCAACCAACGCAGGATCTGACTATTGATACTCAGGTCAGCCGCACCCAGTACCAGTTTACCTTGCAGGCCACGTCACTGGATGCGCTCAGTACCTGGGTGCCACAGTTGATGGAAAAACTCCAGCAACTGCCACAGCTTTCTGATGTCTCCAGCGACTGGCAGGACAAAGGGCTGGTGGCGTATGTCAATGTTGATCGCGACAGCGCCAGCCGTCTGGGGATCAGCATGGCGGATGTCGATAACGCCCTGTACAACGCGTTTGGTCAGCGGCTGATTTCCACTATTTATACTCAGGCCAACCAGTATCGCGTGGTGCTGGAGCACAACACCGAAAATACCCCAGGCCTCGCGGCGCTGGATACCATTCGCCTGACCAGCAGCGACGGCGGCGTGGTGCCGCTAAGCTCAATTGCCAAAATTGAGCAGCGTTTTGCGCCGCTCTCCATCAACCATCTGGATCAGTTCCCGGTAACGACCATCTCCTTTAACGTGCCGGATAACTATTCGCTGGGCGATGCGGTGCAGGCGATTATGGACACCGAAAAGACGCTGAATCTGCCGGTGGATATCACCACGCAGTTCCAGGGCAGCACCCTCGCCTTCCAGTCGGCGCTGGGCAGCACTGTCTGGCTGATTGTCGCGGCGGTGGTGGCGATGTATATCGTGCTCGGCATTCTGTACGAGAGCTTTATTCACCCGATCACCATTCTCTCGACGCTACCCACCGCAGGGGTTGGCGCACTGCTGGCGTTGCTGATTGCTGGTAGCGAACTGGATGTGATTGCGATTATCGGCATTATTTTGCTGATCGGTATCGTGAAGAAGAACGCCATCATGATGATCGACTTCGCGCTGGCTGCTGAGCGCGAGCAAGGCATGTCGCCGCGCGAGGCAATCTACCAGGCTTGTCTGTTGCGTTTTCGTCCGATCCTGATGACCACTCTGGCGGCTCTGCTTGGCGCGCTGCCGCTGATGTTGAGTACCGGGGTCGGCGCGGAACTGCGTCGTCCGTTAGGTATCGGCATGGTCGGCGGTCTGATTGTCAGCCAGGTGCTGACGCTGTTTACCACGCCGGTGATTTATTTGCTGTTCGACCGCCTGGCATTGTGGACCAAAAGCCGCTTTGCCCGTCATGAAGAGGAGGCGTAA", "partial": "0", "query_start": 17656, "query_end": 20775, "orf_dna_sequence": "ATGCAGGTGTTACCCCCAGGCCGCACCGGCGGCCCGTCCCGGCTGTTTATTATGCGTCCGGTGGCCACCACTCTGCTGATGGTGGCTATCCTGCTGGCCGGGATCATCGGCTACCGCTTTCTGCCGGTCTCCGCCCTGCCGGAGGTCGATTACCCGACCATTCAGGTAGTCACCCTCTATCCGGGCGCCAGCCCGGACGTGGTGACCTCCGCCATCACCGCCCCGCTGGAGCGCCAGTTCGGCCAAATGTCAGGCCTCAAGCAGATGTCGTCGCAAAGCTCCGGCGGCGCCTCGGTAGTCACGCTGCAGTTCCAGCTGACCCTGCCGCTGGACGTCGCCGAGCAGGAAGTGCAGGCGGCCATTAACGCCGCCACCAACCTGCTGCCGAGCGATCTGCCCAACCCGCCGGTCTACAGCAAGGTGAACCCGGCGGATCCGCCGATCATGACTCTCGCCGTCACCTCCTCCGCCATCCCGATGACCCAGGTTGAGGACATGGTGGAGACCCGGGTGGCGCAGAAGATCTCCCAGGTTTCCGGCGTCGGTCTGGTGACCCTCGCCGGCGGCCAGCGCCCGGCGGTGCGGGTGAAGCTTAACGCCCAGGCCATCGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCTATCACCAGCGCCAACGTTAACTCCGCGAAAGGCAGCCTCGACGGTCCGGCCCGCGCGGTGACGCTTTCCGCTAACGATCAGATGCAGTCCGCTGAGGATTATCGCCGGCTGATTATCGCTTATCAGAACGGGGCGCCGATCCGGCTCGGCGATGTCGCCAGCGTCGAACAAGGGGCCGAAAACAGCTGGCTCGGGGCGTGGGCCAACCAGCAGCGGGCCATCGTGATGAACGTCCAGCGCCAGCCGGGGGCCAACATCATCGACACCGCCGACAGCATTCGCCAGATGCTGCCGCAGCTTACCGAGAGCCTGCCGAAATCGGTGAAGGTGCAGGTCCTCTCCGACCGGACCACCAACATCCGCGCCTCGGTGCGCGACACCCAGTTTGAGCTGATGCTGGCCATCGCCCTGGTGGTGATGATCATCTACCTGTTTCTGCGCAACGTGCCGGCGACCATTATTCCCGGCGTCGCGGTGCCGCTGTCGCTGGTGGGCACTTTCGCGGTGATGGTGTTCCTCGACTTCTCGATCAACAACCTGACGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGATGCCATCGTGGTGATCGAGAACATCTCGCGCTATATCGAAAAAGGCGAGAAGCCGCTGGCCGCCGCGCTGAAGGGCGCGGGGGAGATCGGCTTCACCATCATCTCCCTCACCTTCTCGCTGATCGCGGTGCTGATCCCGCTGCTGTTTATGGGCGATATCGTCGGCCGCCTGTTCCGCGAATTCGCCGTCACCCTTGCCGTCGCTATTCTTATCTCGGCGGTGGTCTCCCTGACCCTGACGCCGATGATGTGCGCTCGTATGCTAAGCCACGAATCGCTGCGCAAGCAGAACCGATTCTCGCGGGCCAGCGAGCGTTTCTTCGAACGGGTGATCGCCGTCTATGGCCGCTGGCTGAGCCGGGTGCTGAACCATCCGTGGCTGACGCTCGGCGTCGCCCTGAGCACCCTGGCGCTGTCGATTATCCTGTGGGTCTTTATCCCGAAAGGCTTTTTCCCGATCCAGGATAACGGCATTATCCAGGGTACCCTCCAGGCGCCGCAGTCGGTCTCCTTCGCCAGCATGGCCGAGCGCCAGCGGCAGGTGGCCAGCATTATCCTTAAGGATCCGGCGGTGGAGAGTCTGACCTCCTTCGTCGGCGTCGACGGCACCAACCCGGCGCTGAACAGCGCCCGTCTGCAGATCAACCTCAAGCCGCTGGATGAACGCGACGATCGCGTCCAGACGGTGATAAGCCGCCTGCAGCAGGCGGTGGACGGCGTCCCCGGCGTGGCGCTCTACCTGCAGCCGACCCAGGACCTGACCATCGACACCACGGTGAGCCGCACCCAGTATCAGTTCACCCTGCAGGCAAACTCCCTCGAGGCGCTGAGCACCTGGGTACCGCCGCTGCTCAGCCGTCTGCAGGCCCAGCCGCAGCTGGCCGACGTCAGCAGCGACTGGCAGGACAAAGGCCTGGCCGCCTATATCAAGGTGGATCGCGACAGCGCCAGCCGCCTCGGTATCTCAATGGCCGATGTCGATAATGCGCTGTACAACGCCTTCGGCCAGCGGCTGATCTCCACTATTTACACTCAGGCGAATCAGTATCGCGTGGTGCTCGAGCAGGATACCGAGGCGACGCCGGGCCTGGCGGCGCTGGAGAATATCCGTCTCACCAGCAGCGACGGCGGCATCGTGCCGTTGACCGCCATCGCCACGGTGGAGCAGCGCTTTACCCCGCTGTCGGTGAACCACCTCGATCAGTTCCCGGTGACCACCATCTCGTTTAACGTCCCGGACAACTACTCGCTGGGCGAAGCGGTGGAGGCGATCCTCGCCGCCGAACAGTCGCTGGATTTCCCGACCGATATTCGCACCCAGTTCCAGGGCAGCTCGCTGGCCTTCCAGTCGGCGCTCGGCAGCACCGTCTGGCTGGTGGTCGCCGCGGTGGTGGCGATGTATATCGTGCTGGGGGTGCTGTACGAGAGCTTTATCCATCCGATCACGATTCTCTCCACCCTGCCCACCGCCGGGGTCGGGGCGCTGCTGGCGCTGTGGCTGGCGGGCAGCGAGCTGGACGTGATCGCCATCATCGGAATCATTCTGCTGATCGGCATCGTGAAGAAGAACGCCATCATGATGATCGACTTCGCGCTGGCCGCTGAGCGCGAGCAGGGCATGCCGCCGCGGGAGGCGATCTACCAGGCCTGTCTGCTGCGTTTTCGGCCGATCCTGATGACTACCCTCGCCGCCCTGCTCGGCGCCCTGCCGCTGATGCTGAGCACCGGCGTCGGCGCCGAGCTGCGGCGTCCGCTGGGGATCGGCATGGTCGGCGGTCTGATGCTCAGCCAGGTGCTGACCCTGTTCACCACCCCGGTGATCTATCTGCTGTTCGACCGCCTGTCGCTGCACCTGAAGCGCCGCTTCCCGCGTCAGGAAGAGGAGGCGTAA", "orf_prot_sequence": "MQVLPPGRTGGPSRLFIMRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAIPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETVRTAITSANVNSAKGSLDGPARAVTLSANDQMQSAEDYRRLIIAYQNGAPIRLGDVASVEQGAENSWLGAWANQQRAIVMNVQRQPGANIIDTADSIRQMLPQLTESLPKSVKVQVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNVPATIIPGVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERFFERVIAVYGRWLSRVLNHPWLTLGVALSTLALSIILWVFIPKGFFPIQDNGIIQGTLQAPQSVSFASMAERQRQVASIILKDPAVESLTSFVGVDGTNPALNSARLQINLKPLDERDDRVQTVISRLQQAVDGVPGVALYLQPTQDLTIDTTVSRTQYQFTLQANSLEALSTWVPPLLSRLQAQPQLADVSSDWQDKGLAAYIKVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEQDTEATPGLAALENIRLTSSDGGIVPLTAIATVEQRFTPLSVNHLDQFPVTTISFNVPDNYSLGEAVEAILAAEQSLDFPTDIRTQFQGSSLAFQSALGSTVWLVVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALWLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMPPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLMLSQVLTLFTTPVIYLLFDRLSLHLKRRFPRQEEEA", "perc_identity": 90.1}}, "NODE_3_length_454317_cov_40.2449_15 # 20779 # 23856 # 1 # ID=3_15;partial=00;start_type=GTG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.638": {"gnl|BL_ORD_ID|1239|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 20779, "orf_end": 23856, "orf_from": "NODE_3_length_454317_cov_40.2449_15", "model_name": "mdtC", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1315", "pass_evalue": "n/a", "pass_bitscore": "1800", "ARO_accession": "3000794", "ARO_name": "mdtC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1862.04, "max_identities": 937, "cvterm_id": "36849", "query": "MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAMQGGYGKSLKWVLKHSRLTGLVVLGTIVLSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSDGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASEAIDRAMTQLGVPSSVRGSFAGTAHVFQQTMNAQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE", "match": "MKFFALFIYRPVATIL+S+AITLCGILGFR+LPVAPLPQVDFPVI+VSASLPGASPETMASSVATPLERSLGRIAGV+EMTSSSSLGSTRIIL+F+FDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLA TI+QIDGVGDVDVGGSSLPAVRV LNPQALFNQGVSLD VRTA+S+ANVRKPQGALED  HRWQ+QTNDELKTAA+YQPLI+HY NG AVRLGDVATV+DSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRA+LPELQ+TIPAAIDLQIAQDRSPTIRASLEEVEQTL+ISVALVILVVFLFLRSGRAT+IPAV+VPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENI+RHLEAGMKPLQAALQG+REVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISL VSLTLTPMMCGW+LK+ KP +  R RGFGR+LVA+Q GYGKSLKWVL H+RL G+V+LGTI L++WLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIR+DPAVDNVTGFTGGSRVNSGMMFITLKPRD+R ETAQQ+IDRLR KLA EPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDL+ALREWEPKIRK LA LPELADVNSDQQDNGAEM+LVYDRDTM+RLGI VQ AN+LLNNAFGQRQISTIYQP+NQYKVVMEVDP YTQD+SAL+KMFVIN++GK IPL+YFAKWQPANAPLSVNHQGLSAASTISFNLPTG+SLS+AS AIDRAMTQLGVPS+VRGSFAGTA VFQ+TMN+QVILI+AAIATVYIVLG+LYESYVHPLTILSTLPSAGVGALLALE+F+APFSLIALIGIMLLIGIVKKNAIMMVDFALEAQR+GNLTP+EAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSR   Q V+E", "sequence_from_db": "MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE", "sequence_from_broadstreet": "MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE", "dna_sequence_from_broadstreet": "GTGAAGTTTTTTGCCCTCTTCATTTACCGCCCGGTGGCGACGATTTTACTGTCGGTTGCCATTACCCTGTGCGGCATACTGGGCTTCCGTATGCTGCCGGTCGCCCCGCTGCCGCAGGTCGATTTTCCGGTGATTATCGTCAGCGCCTCGCTGCCCGGTGCGTCACCAGAAACAATGGCGTCTTCCGTTGCCACGCCGCTGGAGCGCTCACTTGGGCGCATTGCCGGAGTCAGTGAAATGACCTCCAGCAGTTCGCTCGGCAGCACGCGTATTATTTTGCAGTTTGATTTTGACCGGGATATCAACGGCGCAGCGCGTGATGTGCAGGCGGCGATCAACGCTGCACAAAGTTTGCTGCCCAGTGGGATGCCCAGCCGCCCGACCTATCGCAAAGCGAACCCGTCGGATGCGCCAATTATGATCCTCACGCTGACGTCCGATACTTATTCGCAGGGTGAACTGTACGATTTCGCCTCGACGCAGCTGGCTCCGACGATTTCGCAAATCGACGGTGTTGGTGATGTCGATGTCGGAGGCAGCTCACTGCCCGCCGTACGCGTCGGGCTGAATCCGCAGGCGCTGTTTAATCAGGGCGTGTCGCTGGACGACGTACGCACCGCCGTCAGCAATGCCAACGTGCGTAAACCGCAGGGCGCGCTGGAAGATGGCACTCACCGCTGGCAGATCCAGACCAATGATGAGCTAAAAACCGCCGCTGAATATCAGCCGTTGATTATTCACTACAACAACGGCGGCGCGGTTCGTCTGGGCGATGTGGCGACGGTGACCGACTCAGTGCAGGATGTGCGCAACGCCGGGATGACCAACGCCAAACCGGCTATTTTACTGATGATCCGCAAACTGCCGGAAGCCAATATTATCCAGACGGTTGACAGCATCCGGGCAAAATTACCGGAGTTGCAGGAAACCATTCCGGCGGCGATTGATCTGCAAATTGCCCAGGATCGCTCCCCCACCATTCGCGCCTCGCTGGAAGAAGTCGAGCAAACGCTGATTATCTCGGTGGCGCTGGTGATTCTGGTGGTGTTTTTATTCCTGCGCTCGGGTCGCGCCACTATTATTCCCGCCGTTTCGGTGCCGGTTTCGCTGATTGGTACGTTTGCGGCGATGTACCTGTGCGGATTCAGTCTCAATAACCTTTCGTTAATGGCGCTCACCATCGCTACTGGTTTCGTGGTGGATGACGCCATCGTGGTGCTGGAAAACATTGCACGTCATCTGGAAGCGGGAATGAAACCGTTGCAAGCCGCACTGCAAGGTACTCGCGAAGTCGGTTTTACGGTGCTGTCGATGAGTCTGTCACTGGTGGCGGTGTTCCTGCCGCTGCTGTTGATGGGCGGATTGCCGGGCCGACTGTTACGCGAATTTGCCGTGACGCTTTCTGTCGCCATTGGTATATCGTTGCTGGTTTCTCTGACATTAACGCCAATGATGTGTGGCTGGATGCTGAAAGCCAGCAAGCCGCGCGAGCAAAAGCGACTGCGTGGTTTTGGTCGCATGTTGGTAGCCCTGCAACAAGGCTACGGCAAGTCACTAAAATGGGTGCTCAATCATACCCGTCTGGTGGGCGTGGTGCTGCTTGGCACCATTGCGCTGAATATCTGGCTGTATATCTCGATCCCGAAAACCTTCTTCCCGGAGCAGGACACTGGCGTGTTGATGGGCGGGATTCAGGCGGATCAGAGTATTTCGTTTCAGGCGATGCGCGGTAAGTTGCAGGATTTCATGAAAATTATCCGTGACGATCCGGCAGTGGATAATGTCACCGGCTTTACAGGCGGTTCGCGAGTGAACAGCGGGATGATGTTTATCACCCTCAAGCCACGCGACGAACGCAGCGAAACGGCGCAGCAAATTATCGACCGTCTGCGCGTAAAACTGGCGAAAGAACCGGGGGCGAATCTGTTCCTGATGGCGGTACAGGATATTCGCGTTGGTGGGCGTCAGTCGAACGCCAGCTACCAGTACACGTTGTTATCCGACGACCTGGCGGCACTGCGAGAATGGGAGCCGAAAATCCGCAAAAAACTGGCGACGTTGCCGGAACTGGCGGACGTGAACTCCGATCAGCAGGATAACGGCGCGGAGATGAATCTGGTTTACGACCGCGACACCATGGCACGGCTGGGAATCGACGTACAAGCCGCCAACAGTCTGTTAAATAACGCCTTCGGTCAGCGGCAAATCTCGACCATTTACCAGCCGATGAACCAGTATAAAGTGGTGATGGAAGTGGATCCGCGCTATACCCAGGACATCAGTGCGCTGGAAAAAATGTTCGTTATCAATAACGAAGGCAAAGCGATCCCGCTGTCGTATTTCGCTAAATGGCAACCGGCGAATGCCCCACTATCGGTGAATCATCAGGGATTATCGGCGGCCTCGACCATTTCGTTTAACCTGCCGACCGGAAAATCGCTCTCGGACGCCAGTGCGGCGATCGATCGCGCAATGACCCAGCTTGGTGTGCCTTCGACGGTGCGCGGCAGTTTTGCCGGCACGGCGCAGGTGTTCCAGGAGACGATGAACTCGCAGGTGATCCTGATTATCGCCGCCATCGCCACGGTGTATATCGTGCTGGGTATCCTTTACGAGAGTTACGTACATCCGCTGACGATTCTCTCCACCCTGCCCTCGGCGGGCGTTGGAGCGCTGTTGGCGCTGGAGCTGTTCAATGCCCCGTTCAGCCTAATCGCCCTGATAGGGATCATGCTATTAATCGGCATCGTGAAGAAAAACGCCATTATGATGGTCGATTTTGCGCTTGAAGCCCAACGGCACGGTAACCTGACGCCGCAGGAAGCTATTTTCCAGGCCTGTCTGCTGCGTTTTCGCCCGATTATGATGACTACCCTGGCGGCGCTGTTTGGTGCGCTGCCGCTGGTATTGTCGGGCGGCGACGGCTCGGAGCTGCGGCAACCCCTGGGGATCACCATTGTCGGCGGACTGGTAATGAGCCAGCTCCTTACGCTGTATACCACGCCGGTGGTGTATCTCTTTTTCGACCGTCTGCGGCTGCGTTTTTCGCGTAAACCTAAACAAACGGTAACCGAGTAA", "partial": "0", "query_start": 20779, "query_end": 23853, "orf_dna_sequence": "GTGAAGTTTTTCGCCCTCTTCATTTACCGCCCGGTGGCGACGATCCTCATCTCGCTGGCCATCACCCTGTGCGGCATTCTCGGCTTCCGGCTGCTGCCGGTAGCCCCGCTGCCGCAGGTGGACTTCCCGGTGATCATGGTTAGCGCCTCGCTGCCGGGAGCCTCGCCGGAGACCATGGCCTCGTCGGTGGCCACCCCACTGGAGCGCTCCCTGGGGCGGATTGCCGGGGTCAATGAGATGACCTCCTCCAGCTCGCTCGGCAGCACCCGCATCATTCTTGAGTTTAACTTCGACCGCGATATCAACGGCGCGGCGCGCGACGTTCAGGCGGCGATCAACGCCGCGCAAAGCCTGCTGCCGAGCGGAATGCCCAGCCGGCCGACCTATCGCAAAGCTAATCCGTCAGATGCGCCGATCATGATCCTGACGCTGACCTCGGACACCTACTCCCAGGGTGAGCTGTATGATTTCGCCTCCACCCAGCTGGCGCAGACCATCGCGCAGATCGACGGCGTGGGCGATGTCGACGTCGGCGGCAGCTCCCTGCCGGCGGTGCGCGTCGACCTCAACCCGCAGGCGCTGTTTAACCAGGGCGTGTCGCTGGACGCGGTGCGCACCGCCATCAGCGACGCCAACGTGCGCAAACCGCAGGGGGCGCTGGAGGACAGCGCGCACCGCTGGCAGGTGCAGACCAACGATGAGCTGAAGACCGCCGCCGACTATCAGCCGCTGATCGTCCACTACCAGAATGGCGCCGCGGTGCGGCTGGGAGATGTCGCCACCGTCTCGGATTCGGTGCAGGACGTACGCAACGCCGGGATGACCAACGCCAAACCGGCGATCCTGCTGATGATCCGCAAACTGCCGGAAGCCAATATTATCCAGACGGTGGACAGCATCCGCGCCCGCCTGCCGGAGCTGCAGCAGACCATTCCGGCGGCTATCGACCTGCAGATCGCCCAGGACCGCTCGCCGACCATCCGCGCCTCGCTGGAGGAGGTGGAGCAGACGCTGGTGATTTCGGTGGCGCTGGTGATCCTCGTGGTGTTCCTGTTCCTGCGCTCGGGGCGCGCCACGCTGATCCCGGCCGTCGCCGTCCCGGTATCCTTAATCGGTACCTTCGCCGCGATGTATTTGTGCGGCTTCAGCCTCAATAACCTGTCGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGACGCTATCGTGGTGCTGGAGAATATCTCCCGCCATCTGGAGGCGGGGATGAAACCGCTGCAGGCGGCGCTGCAGGGGAGCCGCGAGGTCGGCTTTACCGTGCTGTCGATGAGCCTGTCGCTGGTGGCGGTGTTTCTGCCGCTGCTGCTGATGGGCGGCCTGCCCGGCCGCCTGCTGCGCGAGTTCGCCGTCACCCTGTCGGTGGCGATCGGCATCTCGCTGGCGGTCTCCCTCACCCTGACGCCGATGATGTGCGGCTGGCTGCTGAAAAGCGGCAAGCCCCACCAGCCGACGCGCAACCGCGGCTTTGGCCGCCTGCTGGTGGCCATGCAGGGCGGCTATGGTAAATCGTTAAAATGGGTACTGAAGCACAGCCGGCTGACCGGCCTGGTGGTGCTGGGCACCATCGTCCTCAGCGTTTGGCTCTACATTTCGATCCCGAAAACCTTCTTCCCGGAGCAGGACACCGGGGTGCTGATGGGCGGCATTCAGGCCGACCAGAGCATCTCCTTCCAGGCGATGCGCGGCAAGCTGCAGGACTTTATGAAGATCATTCGCGAAGATCCGGCGGTGGATAACGTCACCGGCTTTACCGGCGGCTCGCGGGTCAACAGCGGGATGATGTTTATCACCCTCAAGCCGCGCGACCAGCGCCACGAGACGGCGCAGCAGGTGATCGACCGGCTGCGCAAAAAGCTGGCCAACGAGCCCGGGGCCAACCTGTTCCTGATGGCGGTGCAGGATATCCGCGTCGGCGGCCGGCAGTCGAACGCCAGCTATCAGTACACCCTGCTGTCCGACGACCTGTCGGCGCTGCGCGAGTGGGAGCCGAAGATCCGCAAAGCGCTGGCGGCGCTGCCGGAGCTGGCGGACGTCAACTCCGATCAGCAGGACAATGGCGCCGAAATGGACCTGGTCTATGACCGGGATACCATGTCGCGCCTCGGCATCAGCGTCCAGGACGCCAACAACCTGCTGAACAACGCCTTTGGCCAGCGGCAGATCTCTACCATCTACCAGCCGCTCAACCAGTATAAGGTGGTGATGGAGGTGGATCCGGCCTACACCCAGGACGTCAGCGCCCTGGATAAGATGTTCGTCATTAACAGCGACGGCAAGCCGATCCCGCTGGCCTACTTCGCCAAATGGCAGCCGGCCAATGCCCCGCTGTCGGTGAACCACCAGGGGCTGTCGGCGGCATCCACTATCTCCTTTAACCTGCCCACCGGCCGCTCGCTGTCGGAAGCCAGCGAGGCCATTGACCGCGCGATGACCCAGCTCGGGGTGCCGTCGAGCGTGCGCGGCTCCTTTGCCGGTACCGCTCACGTGTTCCAGCAGACCATGAACGCGCAGGTGATCCTGATCCTCGCGGCTATCGCCACGGTCTATATCGTGCTGGGGGTGCTATATGAGAGCTATGTGCATCCGTTGACCATCCTCTCGACGCTGCCCTCCGCCGGGGTGGGCGCTCTGCTGGCGCTGGAGATCTTCGATGCCCCGTTCAGCCTAATCGCCCTGATTGGGATTATGTTATTAATTGGCATCGTTAAGAAAAACGCCATCATGATGGTTGATTTTGCCCTGGAGGCGCAGCGCAACGGCAACCTGACGCCGGAAGAGGCGATTTTCCAGGCCTGCCTGCTGCGTTTCCGGCCGATTATGATGACCACCCTCGCCGCGCTGTTCGGCGCCCTGCCGCTGGTGCTCTCCGGGGGCGATGGCTCTGAGCTGCGCCAGCCGCTGGGGATCACCATCGTCGGCGGTCTGGTGATGAGCCAGCTGTTAACGCTCTACACCACGCCGGTGGTCTATCTTTTCTTTGACCGTCTGCGGCTGCGTTTTTCGCGTCACTCCTCTCAACCGGTAAGCGAATAA", "orf_prot_sequence": "MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAMQGGYGKSLKWVLKHSRLTGLVVLGTIVLSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSDGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASEAIDRAMTQLGVPSSVRGSFAGTAHVFQQTMNAQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE", "perc_identity": 91.41}}, "NODE_3_length_454317_cov_40.2449_18 # 26745 # 27467 # 1 # ID=3_18;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.611": {"gnl|BL_ORD_ID|1258|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 26745, "orf_end": 27467, "orf_from": "NODE_3_length_454317_cov_40.2449_18", "model_name": "baeR", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1337", "pass_evalue": "n/a", "pass_bitscore": "450", "ARO_accession": "3000828", "ARO_name": "baeR", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.2562e-165, "bit_score": 454.136, "max_identities": 218, "cvterm_id": "36839", "query": "MTELPVDENTPRILIVEDEPKLGQLLIDYLQAAGYAPALINHGDKVLPYVRQSPPHLILLDLMLPGTDGLTLCREIRRFSDVPVVMVTAKIEEIDRLLGLEIGADDYVCKPYSPREVVARVKTILRRCKPQRDLQALDAQSPLIVDEGRFQASWRDKLLDLTPAEFRLLKTLSQEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEALDAEQSFIRAVYGVGYRWEADACRLA", "match": "MTELP+DENTPRILIVEDEPKLGQLLIDYL+AA YAP LI+HGD+VLPYVRQ+PP LILLDLMLPGTDGLTLCREIRRFSD+P+VMVTAKIEEIDRLLGLEIGADDY+CKPYSPREVVARVKTILRRCKPQR+LQ  DA+SPLI+DEGRFQASWR K+LDLTPAEFRLLKTLS EPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLE+LDAEQSFIRAVYGVGYRWEADACR+ ", "sequence_from_db": "MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV", "sequence_from_broadstreet": "MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV", "dna_sequence_from_broadstreet": "ATGACCGAGTTACCAATCGACGAAAACACACCGCGTATTTTGATCGTGGAAGATGAACCGAAGCTGGGGCAGTTGCTCATTGATTATCTGCGTGCTGCGAGCTATGCGCCGACGCTTATCAGCCACGGCGATCAGGTACTGCCGTATGTGCGCCAGACACCACCGGATCTGATCCTGTTAGATCTGATGCTCCCTGGCACCGATGGCCTGACGCTGTGCCGGGAAATTCGTCGTTTTTCTGACATTCCGATCGTGATGGTGACGGCAAAAATCGAAGAGATCGATCGCCTGCTGGGGCTGGAGATTGGCGCAGATGATTATATCTGTAAGCCGTACAGCCCACGGGAAGTGGTAGCGCGCGTCAAAACCATTTTGCGCCGTTGCAAACCGCAGCGCGAGTTGCAGCAACAGGATGCTGAAAGCCCGTTGATTATCGACGAAGGTCGTTTTCAGGCTTCATGGCGCGGTAAAATGCTTGACCTGACGCCTGCGGAATTTCGTCTGCTGAAAACGCTCTCTCACGAACCAGGAAAAGTGTTCTCCCGCGAGCAATTGCTCAATCATCTTTATGACGACTACCGCGTAGTAACCGACCGCACCATCGACAGCCACATTAAAAACCTGCGCCGCAAGCTGGAATCTCTCGACGCCGAACAGTCATTTATCCGCGCCGTTTATGGCGTCGGTTACCGCTGGGAAGCCGACGCCTGCCGCATCGTTTAG", "partial": "0", "query_start": 26745, "query_end": 27464, "orf_dna_sequence": "ATGACTGAATTGCCTGTAGATGAAAACACCCCACGCATCCTTATCGTGGAAGATGAACCGAAGCTCGGCCAACTGCTGATTGATTATCTGCAGGCCGCCGGCTATGCGCCTGCGTTGATTAACCACGGCGACAAGGTCCTGCCCTACGTCCGCCAGTCGCCGCCGCACCTGATCCTGCTGGATCTGATGCTGCCCGGTACCGACGGTCTGACGCTGTGCCGGGAAATTCGCCGCTTCTCCGATGTTCCGGTGGTGATGGTGACGGCGAAAATCGAAGAGATCGACCGTTTGCTGGGGCTGGAAATAGGCGCCGACGACTATGTCTGCAAGCCCTACAGCCCGCGGGAAGTGGTCGCCCGGGTAAAAACCATCCTCCGCCGCTGCAAGCCGCAGCGCGATCTGCAGGCGCTGGACGCCCAGAGCCCGCTGATTGTCGACGAAGGTCGTTTTCAGGCCTCCTGGCGCGACAAGCTGCTGGACCTCACTCCCGCCGAGTTCCGGCTGCTGAAAACCCTCTCCCAGGAGCCGGGCAAAGTGTTCTCCCGCGAACAGCTACTCAACCATCTGTATGACGATTATCGGGTAGTCACCGATCGCACCATCGACAGCCACATCAAGAACCTGCGGCGCAAGCTGGAGGCGCTGGACGCCGAGCAGTCGTTTATCCGCGCGGTGTATGGCGTTGGCTACCGCTGGGAAGCGGACGCCTGCCGGCTGGCGTAG", "orf_prot_sequence": "MTELPVDENTPRILIVEDEPKLGQLLIDYLQAAGYAPALINHGDKVLPYVRQSPPHLILLDLMLPGTDGLTLCREIRRFSDVPVVMVTAKIEEIDRLLGLEIGADDYVCKPYSPREVVARVKTILRRCKPQRDLQALDAQSPLIVDEGRFQASWRDKLLDLTPAEFRLLKTLSQEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEALDAEQSFIRAVYGVGYRWEADACRLA", "perc_identity": 90.83}}, "NODE_3_length_454317_cov_40.2449_285 # 330238 # 333351 # 1 # ID=3_285;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.609": {"gnl|BL_ORD_ID|1341|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 330238, "orf_end": 333351, "orf_from": "NODE_3_length_454317_cov_40.2449_285", "model_name": "acrD", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1427", "pass_evalue": "n/a", "pass_bitscore": "1900", "ARO_accession": "3000491", "ARO_name": "acrD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1949.48, "max_identities": 943, "cvterm_id": "36839", "query": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "match": "MANFFIDRPIFAWVLAILLCLTG LAI SLPVEQYPDLAPPNVR+TANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSS TGQA++TLSF AGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILT+AFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNS+QMT KDVTDAI SQNAQIAVGQLGGTPSVDKQALNATIN+QSLLQTPEQFR+ITLRVNQDGSEV LGDVATVEMGAEKYDYLSR+N +PASGLG+KLASGANEMATAE V+NRL+ELAQ+FPHGLEYKVAYETTSFVKASI DVVKTLLEAI LVFLVMYLFLQNFRATLIPTIAVPVVLMGTF+VLYA GYS+NTLTMFAMVLAIGLLVDDAIVVVENVE IMSEEGL+PREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKP+K GE H + GFF WFN+ FNR+A RYE  V KILHRSLRW++IYVLLLGGMVFLFL LPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVV++ E Y+  +EK N+ SVFATVGSGPGGNGQNVARMF+RLKDW +RD +TGTSFAIIERATKAFNQI EARVIASSPPAISGLGSSAGFDMEL+DHAG GHDALMAAR+ LL LA +NP LTRVRHNGLDDSPQLQ+DIDQRKAQALGV+IDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAA YRMLPDDINLWYVRN  G MVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPG+STGTAMD+ME L  QLP GFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANE+N+KG DL  ATL ACRQRLRPILMTSLAFIFGVLPMATSTGAGSG QHAVGTGVMGGMISAT+LAI+FVPLFFVLVRRRFPLK RP+", "sequence_from_db": "MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE", "sequence_from_broadstreet": "MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE", "dna_sequence_from_broadstreet": "ATGGCGAATTTCTTTATTGATCGCCCCATTTTTGCCTGGGTGCTGGCAATCCTGTTGTGTCTGACAGGTACCCTGGCGATTTTTTCATTGCCCGTTGAACAATACCCCGATCTCGCGCCACCGAATGTGCGAGTGACCGCTAACTATCCCGGCGCATCGGCCCAGACGCTGGAAAACACCGTGACCCAGGTTATCGAGCAAAATATGACCGGCCTCGATAATCTCATGTATATGTCATCTCAGAGCAGTGGCACCGGTCAGGCATCTGTCACTTTAAGTTTTAAAGCAGGCACCGATCCGGACGAAGCCGTGCAGCAAGTACAAAACCAGCTGCAATCAGCCATGCGAAAGTTACCGCAGGCGGTGCAAAATCAGGGCGTGACGGTGCGTAAAACCGGCGATACCAACATTCTGACCATTGCCTTCGTCTCTACCGATGGTTCGATGGATAAACAGGATATTGCTGATTATGTTGCCAGTAATATTCAGGACCCGTTAAGCCGCGTGAATGGCGTCGGGGATATCGATGCCTATGGTTCGCAATATTCCATGCGTATCTGGCTGGACCCGGCGAAACTCAACAGTTTCCAGATGACGGCTAAAGATGTCACTGATGCCATTGAGTCACAGAACGCGCAGATTGCGGTTGGGCAACTTGGTGGTACACCTTCCGTCGATAAGCAGGCGCTCAACGCCACCATTAACGCCCAGTCACTGCTGCAAACACCAGAACAGTTCCGCGATATCACCTTGCGGGTCAATCAGGACGGCTCAGAGGTAAGGCTGGGCGATGTCGCCACCGTCGAAATGGGGGCGGAGAAATACGATTATCTTAGCCGCTTCAATGGTAAGCCAGCCTCCGGGCTGGGGGTAAAACTGGCCTCCGGCGCTAACGAAATGGCGACAGCGGAGCTGGTGCTCAATCGTCTCGACGAGCTGGCGCAGTATTTCCCGCATGGACTGGAATACAAGGTGGCGTATGAAACCACCTCGTTTGTTAAAGCCTCCATTGAAGACGTGGTGAAAACGCTGCTGGAAGCTATCGCTCTGGTTTTCCTCGTTATGTATCTGTTCCTGCAAAACTTCCGCGCCACGCTGATACCCACTATCGCCGTGCCGGTGGTGTTGATGGGAACCTTCTCCGTACTTTACGCCTTCGGTTACAGCGTCAACACCTTAACCATGTTCGCGATGGTGCTGGCGATCGGTCTGCTGGTGGATGACGCCATCGTGGTGGTGGAAAACGTCGAACGTATTATGAGTGAGGAAGGACTCACTCCTCGCGAAGCCACACGTAAATCGATGGGGCAGATCCAGGGGGCACTGGTCGGGATTGCGATGGTTCTTTCGGCGGTATTTGTACCAATGGCCTTCTTCGGCGGCACCACCGGTGCCATCTATCGCCAGTTCTCTATTACCATTGTTGCGGCGATGGTGCTGTCAGTACTGGTAGCGATGATCCTCACTCCGGCTCTGTGTGCCACACTACTTAAGCCACTGAAAAAAGGTGAGCATCATGGGCAAAAAGGCTTTTTTGCCTGGTTTAACCAGATGTTTAACCGCAACGCCGAACGCTACGAAAAAGGGGTGGCGAAAATTCTCCACCGTAGCCTGCGCTGGATTGTGATTTATGTCCTGCTGCTTGGCGGCATGGTGTTCCTGTTCCTGCGTTTGCCGACGTCGTTCTTACCGCTGGAAGACCGTGGCATGTTTACTACCTCGGTACAGTTGCCCAGCGGTTCAACGCAACAACAGACCCTGAAAGTCGTTGAGCAAATCGAGAAATACTACTTCACCCATGAAAAAGACAACATCATGTCGGTGTTTGCCACCGTTGGTTCTGGCCCTGGGGGTAACGGGCAAAACGTGGCGCGAATGTTTATCCGCCTGAAAGACTGGAGCGAACGCGACAGTAAGACCGGCACCTCGTTTGCCATTATCGAGCGTGCAACGAAGGCGTTTAACCAAATTAAAGAAGCTCGCGTTATCGCCAGCAGCCCGCCAGCAATTAGCGGTCTTGGTAGTTCTGCAGGTTTTGATATGGAGTTGCAGGACCACGCTGGAGCGGGTCACGATGCGCTGATGGCAGCACGTAATCAGTTGCTGGCGCTGGCGGCGGAAAACCCGGAGCTAACCCGTGTGCGCCATAACGGCCTCGACGACAGTCCGCAGTTGCAGATTGATATCGACCAGCGTAAAGCTCAGGCGCTGGGCGTTGCTATCGACGATATTAACGACACACTGCAAACCGCCTGGGGTTCGAGCTATGTGAATGACTTTATGGATCGCGGTCGCGTGAAGAAAGTCTATGTGCAGGCAGCTGCGCCGTATCGCATGCTGCCAGATGACATCAATCTCTGGTATGTCCGAAATAAAGATGGCGGCATGGTGCCCTTCTCTGCTTTCGCGACCTCACGCTGGGAAACAGGCTCGCCGCGTCTGGAACGCTATAACGGTTATTCTGCGGTTGAGATTGTTGGGGAAGCCGCACCGGGGGTCAGTACCGGTACGGCGATGGATATTATGGAATCGTTAGTGAAGCAGCTGCCAAACGGCTTTGGTCTGGAGTGGACGGCGATGTCGTATCAGGAGCGGCTTTCCGGCGCGCAGGCTCCGGCGCTGTACGCCATTTCCTTGCTGGTGGTATTCCTGTGTCTGGCTGCGTTGTATGAAAGCTGGTCGGTGCCGTTCTCGGTAATGCTGGTCGTGCCGCTGGGGGTAATCGGCGCGCTGCTGGCAACCTGGATGCGCGGGCTGGAAAACGACGTTTACTTCCAGGTGGGCCTGTTAACGGTCATTGGTTTATCGGCGAAAAACGCCATCCTGATCGTCGAGTTTGCTAACGAGATGAACCAAAAAGGCCACGACCTGTTTGAAGCGACGCTCCACGCCTGCCGTCAGCGTTTACGCCCGATTCTGATGACCTCGCTGGCATTTATCTTCGGCGTATTGCCAATGGCAACCAGCACGGGTGCCGGTTCCGGTGGTCAGCATGCGGTGGGTACTGGCGTAATGGGCGGGATGATTTCGGCCACTATTCTGGCTATTTACTTCGTGCCGCTGTTCTTTGTGCTGGTGCGCCGCCGCTTCCCGCTGAAGCCGCGCCCGGAATAA", "partial": "0", "query_start": 330238, "query_end": 333348, "orf_dna_sequence": "ATGGCGAATTTCTTTATCGATCGCCCCATTTTTGCATGGGTGCTGGCAATCCTGTTATGCCTGACGGGCGCCCTTGCCATTTTGTCGCTGCCGGTTGAACAGTATCCCGACCTCGCCCCGCCGAATGTGCGGATCACCGCCAACTATCCCGGCGCCTCCGCGCAAACCCTGGAGAATACCGTCACTCAGGTTATCGAACAGAATATGACCGGCCTCGATAACCTGATGTATATGTCCTCCCAGAGCAGCGCCACCGGCCAGGCGACGATCACCCTCAGCTTTACCGCCGGTACCGACCCGGATGAAGCCGTGCAGCAGGTTCAGAACCAGCTACAGTCGGCGATGCGTAAGCTGCCGCAGGCGGTGCAAAACCAGGGGGTGACGGTGCGCAAGACCGGTGATACCAATATCCTGACGCTCGCCTTCGTCTCCACTGACGGCAGTATGGATAAACAAGATATCGCCGACTACGTCGCCAGTAACATCCAGGACCCGCTCAGCCGCGTCAACGGCGTGGGGGATATCGACGCCTACGGTTCGCAATACTCAATGCGCATCTGGCTCGACCCGGCGAAGCTCAACAGCTACCAGATGACCACCAAGGATGTTACCGACGCCATCAGTTCGCAGAACGCCCAGATTGCCGTCGGCCAGCTTGGCGGGACGCCTTCGGTCGATAAGCAAGCGCTGAACGCCACCATCAACTCGCAATCTCTGCTGCAAACCCCGGAGCAGTTCCGCAATATCACTCTGCGCGTCAATCAGGATGGTTCAGAGGTGACGCTGGGCGATGTCGCCACCGTCGAGATGGGGGCGGAGAAGTACGACTATCTTAGCCGCTACAACCGCCAGCCGGCCTCAGGCCTCGGGATCAAGCTGGCTTCCGGCGCCAACGAAATGGCCACCGCGGAGCGCGTGATCAATCGCCTCAATGAGCTGGCGCAGTTTTTCCCCCACGGTCTGGAATATAAGGTCGCCTACGAGACCACCTCCTTCGTGAAGGCTTCCATCACCGACGTGGTGAAAACCCTGCTGGAGGCAATCCTGCTGGTCTTCCTCGTGATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGATGGGCACTTTCGCGGTGCTGTATGCCTGTGGTTACAGCATTAACACCCTGACGATGTTCGCGATGGTGTTGGCGATCGGCCTGCTGGTGGATGACGCCATCGTGGTGGTGGAGAACGTCGAGCACATCATGAGCGAGGAGGGCCTGTCGCCACGCGAGGCGACCCGCAAATCGATGGGACAAATTCAGGGCGCGCTGGTAGGGATCGCGATGGTGCTGTCGGCGGTATTTGTGCCGATGGCCTTCTTCGGCGGCACCACCGGCGCCATCTATCGCCAGTTCTCAATCACTATCGTCGCGGCGATGGTCCTCTCGGTGCTGGTGGCCATGATCCTCACCCCTGCCCTTTGCGCCACGCTGCTTAAGCCGGTTAAGCCAGGTGAATCCCATGAAAGAACAGGCTTCTTCGGCTGGTTCAACCGCACCTTCAACCGCAGCGCCAGCCGCTACGAAACCTTCGTCGGCAAAATCCTGCACCGCTCGCTGCGCTGGATGCTGATCTACGTCCTCCTGCTCGGCGGGATGGTGTTCCTGTTTCTGCATTTGCCGACCTCGTTCCTGCCGCTGGAGGATCGCGGGATGTTCACCACCTCGGTCCAGTTGCCGAGCGGCAGCACCCAGCAGCAGACGCTGAAGGTGGTGCAGAAGGCGGAAGATTACTTTCTCAATAACGAGAAGCAGAACGTCGAGTCGGTGTTCGCTACCGTTGGCTCCGGCCCCGGCGGCAATGGGCAGAACGTGGCCCGCATGTTCGTTCGTCTCAAAGACTGGGACCAGCGCGACCCGCAAACCGGCACCTCCTTTGCCATTATTGAACGCGCCACCAAAGCGTTTAATCAGATTAACGAAGCGCGGGTTATCGCCAGCAGCCCGCCGGCGATCAGCGGCCTCGGCAGTTCGGCAGGCTTCGATATGGAGCTGGAGGATCATGCCGGGAAGGGGCACGATGCGCTGATGGCGGCGCGCGATACGCTGCTTGAGCTGGCCGGGAAAAATCCGCTGTTGACCCGCGTCCGGCATAACGGGCTCGATGACAGTCCGCAGCTGCAGGTCGATATCGATCAGCGTAAAGCGCAGGCGCTGGGCGTCTCCATTGACGACATCAACGATACGCTGCAAACCGCGTGGGGGTCGAGCTACGTCAACGACTTTATGGATCGCGGCCGGGTAAAGAAAGTCTACGTCCAGGCGGCGGCGAAATACCGGATGCTGCCTGACGATATCAATCTTTGGTACGTGCGCAACAGCAGCGGCACGATGGTGCCATTCTCGGCCTTCGCCACCTCGCGCTGGGAGACCGGCTCGCCGCGGCTGGAGCGCTACAATGGCTACTCAGCGGTCGAGATCGTCGGTGAGGCGGCGCCGGGTATCAGTACCGGTACCGCGATGGACATGATGGAGAAGCTGGCCGCGCAGTTACCCACCGGCTTTGGCCTCGAATGGACCGCCATGTCCTACCAGGAACGCCTCTCTGGCGCTCAGGCGCCGGCCCTGTATGCTATTTCTCTGCTGGTGGTGTTCCTGTGCCTGGCGGCGCTGTACGAGAGCTGGTCGGTGCCGTTCTCGGTGATGCTGGTGGTGCCGCTGGGGGTGATTGGCGCCCTGCTGGCGACCTGGATGCGCGGTCTGGAGAATGACGTGTACTTCCAGGTGGGTCTGTTGACGGTGATCGGCCTGTCGGCGAAAAACGCCATTCTGATCGTCGAGTTCGCCAATGAGCTCAACGAGAAGGGCCAGGATCTGCTCAGCGCCACGCTGTCGGCTTGCCGTCAGCGCCTGCGCCCCATCCTGATGACCTCGCTGGCGTTCATCTTCGGCGTGCTGCCGATGGCGACCAGCACCGGCGCCGGTTCCGGCAGCCAGCATGCGGTCGGCACCGGAGTGATGGGCGGGATGATCTCCGCCACCGTGCTGGCGATCTTTTTCGTGCCGCTGTTCTTTGTGCTGGTGCGTCGCCGTTTTCCGCTAAAGGAGCGTCCGCAATAA", "orf_prot_sequence": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "perc_identity": 90.94}, "gnl|BL_ORD_ID|137|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 330238, "orf_end": 333351, "orf_from": "NODE_3_length_454317_cov_40.2449_285", "model_name": "adeF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "153", "pass_evalue": "n/a", "pass_bitscore": "750", "ARO_accession": "3000777", "ARO_name": "adeF", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 752.666, "max_identities": 433, "cvterm_id": "35535", "query": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGS-QYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLK--PVKPGESHERT------GFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGG--NGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQ-LPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVR", "match": "++ FFIDRPIFA VL++L+ L G L++  LP+ +YP++ PP+V + A YPGA+ + +  TV   +E+++ G+++++YM SQ+++ G  TIT++F  G DPD+A Q VQN++  AM +LP+ VQ  GVT  K+  T  + +   S D   D   + +Y   N++D L+R+ GVG++  +GS  Y+MR+WLDP K+    +T  ++ +AI  QN Q+A G +G +PS     L  ++N+Q  L T ++F +I L+   DG+   LGDVA VE+ A +Y   S  + + A  + I  A GAN +  +++V + + EL++ FP  ++Y + Y+ T FV+ASI  VV TLLEAI LV +V+ LFLQ +RA++IP +AVPV ++GTFA++ A GYSIN L++F MVLAIG++VDDAIVVVENVE  + E GL+PREAT ++M ++ G ++ IA+ L AVFVP+AF  G TG  Y+QF++TI  + V+S   ++ L+PAL A LLK    KP ++  R        FF  FNR F+R++ RY   V +++      M +Y  LLG  V +   +P  F+P +D+    +  QLP+G++  +T  V++K  D  L  ++  VES  A  G    G  N  +   +FV LK +D+R  +  ++ AI     + ++ I +A +    PP + GLG+  GF ++LED    G+ AL  A    ++ A   P L  +  +   + PQL VD+D+ KA+  GV++ D+ +T+Q   GS YVNDF   GRV +V  QA A +R  P+DI     RNS+G MVP S+        G   + RYNGY++ +I G  APG S+  A   +E++AAQ LP G   EWT ++YQ+ L+G     ++ IS+L+VFL LAA YES ++P +V+L+VP+G++ AL   W+   +N+++ Q+GL+ ++GL+ KNAILIVEFA EL  +G     A + A R RLRPILMTS+AFI GV+P+ TSTGAGS  +HA+G  V  GMI  T   +F  P F+VL+R", "sequence_from_db": "ISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPS--NSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNI-EAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKP-DALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTAL--KQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIR", "sequence_from_broadstreet": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH", "dna_sequence_from_broadstreet": "ATGAATATTTCTAAATTTTTTATTGATCGGCCGATCTTTGCTGGTGTGCTATCAGTCTTGATTTTACTCGCCGGTCTCCTTTCGGTATTTCAGTTACCGATTTCTGAATATCCCGAGGTTGTTCCACCATCTGTGGTGGTACGCGCCCAATATCCGGGTGCAAACCCAAAAGTGATTGCTGAAACGGTTGCATCTCCGCTCGAAGAGTCAATCAACGGCGTCGAAGACATGCTGTATATGCAATCTCAAGCAAACAGCGACGGTAACCTAACCATTACGGTGAACTTTAAGCTCGGTATCGACCCAGACAAAGCCCAACAATTGGTTCAAAACCGTGTGTCTCAGGCCATGCCCCGTTTACCTGAAGATGTACAGCGCTTAGGTGTAACCACACTAAAAAGCTCACCTACTTTAACTATGGTAGTGCATCTGACCTCACCAGATAATCGCTATGACATGACCTACTTACGTAACTATGCGGTGCTCAACGTGAAAGACCGTTTAGCGCGTTTACAAGGGGTTGGTGAAGTCGGATTATTTGGTTCTGGTGACTACGCGATGCGTGTATGGCTTGACCCGCAAAAAGTAGCGCAGCGTAACCTCACCGCGACCGAAATTGTGAATGCAATCCGTGAACAAAATATTCAGGTTGCAGCGGGTACAATCGGTGCATCACCAAGTAATTCACCTTTACAGCTTTCAGTCAATGCTCAAGGTCGTTTAACTACTGAACAAGAATTCGCAGATATCATTTTAAAAACTGCACCAGATGGCGCGGTTACCCGATTGGGTGATGTTGCTCGTGTCGAACTTGCAGCCTCTCAATATGGCTTACGTTCATTGCTTGATAATAAACAAGCGGTCGCGATTCCAATTTTCCAAGCACCGGGTGCGAATGCTTTACAAGTTTCCGATCAAGTGCGTAGCACAATGAAGGAGCTTTCAAAAGATTTCCCATCTTCAATTAAATACGACATTGTTTATGACCCGACTCAATTCGTACGTGCAAGTATTAAAGCGGTCGTTCATACCTTACTTGAAGCAATTACACTGGTTGTTGTGGTCGTTATTTTATTCTTGCAAACATGGCGTGCCTCAATCATTCCATTGCTTGCCGTACCGGTTTCAATTATTGGTACATTCGCGCTCATGCTCGCTTTTGGTTACTCAATCAATGCGCTATCACTGTTCGGAATGGTACTTGCCATCGGGATTGTCGTCGATGACGCGATTGTGGTCGTCGAAAATGTCGAGAGGAATATTGAAGCAGGCTTAAACCCAAGGGAGGCGACTTACCGTGCCATGCGAGAAGTCAGTGGACCGATTATTGCCATTGCTTTAACACTTGTTGCAGTATTCGTACCTCTTGCCTTTATGACAGGCTTAACAGGGCAATTCTATAAACAATTTGCCATGACCATTGCCATTTCAACGGTTATTTCGGCATTTAACTCGCTTACCCTATCTCCTGCTTTGGCAGCGCTGTTACTGAAAGGACATGATGCTAAACCGGATGCCTTAACACGTATTATGAATCGTGTATTCGGTCGTTTCTTTGCACTGTTTAACCGTGTGTTTTCACGTGCTTCAGACCGTTATAGTCAAGGCGTCAGCCGTGTCATTTCCCATAAAGCTTCGGCAATGGGTGTCTATGCAGCACTCTTAGGTTTAACCGTTGGTATTTCCTATATTGTTCCAGGTGGTTTCGTTCCTGCGCAGGACAAACAATATTTAATTAGCTTTGCGCAGCTACCAAACGGCGCATCATTAGATCGTACCGAAGCGGTCATTCGTAAAATGAGTGACACTGCACTTAAACAACCTGGTGTAGAAAGTGCAGTTGCCTTTCCTGGCCTATCAATTAACGGTTTCACCAATAGCTCAAGTGCCGGTATTGTCTTTGTGACTTTAAAGCCATTTGATGAACGTAAGGCAAAAGACTTATCTGCAAATGCAATTGCAGGTGCGCTCAACCAGAAATATTCAGCTATTCAAGATGCCTATATCGCGGTTTTCCCACCGCCACCAGTGATGGGCTTAGGTACTATGGGCGGCTTTAAACTACAACTTGAAGACCGAGGTGCCTTAGGCTATTCAGCCTTGAACGATGCTGCACAAAACTTTATGAAGGCAGCACAATCAGCCCCTGAACTGGGTCCAATGTTCTCAAGTTATCAAATTAACGTACCTCAACTCAACGTAGATCTGGACCGTGTAAAAGCTAAACAGCAAGGCGTTGCTGTGACAGATGTTTTCAATACTATGCAGATTTATTTAGGTTCTCAGTACGTTAACGACTTTAACCGCTTTGGACGTGTTTATCAGGTTCGTGCACAAGCCGATGCGCCTTTCCGTGCTAACCCTGAAGATATTTTGCAGCTTAAAACCCGTAATAGTGCCGGACAAATGGTGCCATTATCTTCATTGGTGAATGTAACTCAAACCTATGGTCCTGAAATGGTCGTTCGTTATAACGGTTACACATCAGCAGATATTAACGGTGGCCCTGCCCCAGGTTATTCATCTAGCCAAGCAGAAGCTGCGGTTGAACGTATTGCTGCACAAACTCTACCGCGTGGTATCAAGTTTGAATGGACAGATTTAACTTATCAAAAAATCTTGGCTGGTAATGCTGGACTTTGGGTATTCCCTATTAGCGTATTACTCGTGTTCTTAGTGTTAGCTGCTCAGTATGAAAGCTTAACCCTACCATTAGCAGTTATCTTAATTGTACCAATGGGAATCTTAGCGGCTCTGACAGGTGTCTGGTTGACAGCTGGAGATAACAACATCTTTACTCAAATCGGTCTAATGGTACTGGTCGGGCTAGCCTGTAAAAATGCCATCTTAATTGTCGAATTTGCGAGGGAACTTGAAATGCAAGGTGCGACTGCCTTTAAAGCAGCCGTTGAAGCAAGTCGTCTACGTTTACGCCCAATTTTAATGACCTCTATTGCATTTATTATGGGTGTAGTGCCACTGGTTACTTCAACTGGCGCAGGTTCTGAAATGCGACATGCGATGGGTGTTGCCGTATTCTTCGGTATGATCGGTGTAACATTCTTTGGTTTATTCCTCACCCCGGCCTTTTACGTTCTGATTCGTACCCTCAACAGCAAACATAAACTGCATTCTGCGGCAGTTCATGAAGCGCCGTTAGCTAGCCCACATGATCATTAA", "partial": "0", "query_start": 330238, "query_end": 333318, "orf_dna_sequence": "ATGGCGAATTTCTTTATCGATCGCCCCATTTTTGCATGGGTGCTGGCAATCCTGTTATGCCTGACGGGCGCCCTTGCCATTTTGTCGCTGCCGGTTGAACAGTATCCCGACCTCGCCCCGCCGAATGTGCGGATCACCGCCAACTATCCCGGCGCCTCCGCGCAAACCCTGGAGAATACCGTCACTCAGGTTATCGAACAGAATATGACCGGCCTCGATAACCTGATGTATATGTCCTCCCAGAGCAGCGCCACCGGCCAGGCGACGATCACCCTCAGCTTTACCGCCGGTACCGACCCGGATGAAGCCGTGCAGCAGGTTCAGAACCAGCTACAGTCGGCGATGCGTAAGCTGCCGCAGGCGGTGCAAAACCAGGGGGTGACGGTGCGCAAGACCGGTGATACCAATATCCTGACGCTCGCCTTCGTCTCCACTGACGGCAGTATGGATAAACAAGATATCGCCGACTACGTCGCCAGTAACATCCAGGACCCGCTCAGCCGCGTCAACGGCGTGGGGGATATCGACGCCTACGGTTCGCAATACTCAATGCGCATCTGGCTCGACCCGGCGAAGCTCAACAGCTACCAGATGACCACCAAGGATGTTACCGACGCCATCAGTTCGCAGAACGCCCAGATTGCCGTCGGCCAGCTTGGCGGGACGCCTTCGGTCGATAAGCAAGCGCTGAACGCCACCATCAACTCGCAATCTCTGCTGCAAACCCCGGAGCAGTTCCGCAATATCACTCTGCGCGTCAATCAGGATGGTTCAGAGGTGACGCTGGGCGATGTCGCCACCGTCGAGATGGGGGCGGAGAAGTACGACTATCTTAGCCGCTACAACCGCCAGCCGGCCTCAGGCCTCGGGATCAAGCTGGCTTCCGGCGCCAACGAAATGGCCACCGCGGAGCGCGTGATCAATCGCCTCAATGAGCTGGCGCAGTTTTTCCCCCACGGTCTGGAATATAAGGTCGCCTACGAGACCACCTCCTTCGTGAAGGCTTCCATCACCGACGTGGTGAAAACCCTGCTGGAGGCAATCCTGCTGGTCTTCCTCGTGATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGATGGGCACTTTCGCGGTGCTGTATGCCTGTGGTTACAGCATTAACACCCTGACGATGTTCGCGATGGTGTTGGCGATCGGCCTGCTGGTGGATGACGCCATCGTGGTGGTGGAGAACGTCGAGCACATCATGAGCGAGGAGGGCCTGTCGCCACGCGAGGCGACCCGCAAATCGATGGGACAAATTCAGGGCGCGCTGGTAGGGATCGCGATGGTGCTGTCGGCGGTATTTGTGCCGATGGCCTTCTTCGGCGGCACCACCGGCGCCATCTATCGCCAGTTCTCAATCACTATCGTCGCGGCGATGGTCCTCTCGGTGCTGGTGGCCATGATCCTCACCCCTGCCCTTTGCGCCACGCTGCTTAAGCCGGTTAAGCCAGGTGAATCCCATGAAAGAACAGGCTTCTTCGGCTGGTTCAACCGCACCTTCAACCGCAGCGCCAGCCGCTACGAAACCTTCGTCGGCAAAATCCTGCACCGCTCGCTGCGCTGGATGCTGATCTACGTCCTCCTGCTCGGCGGGATGGTGTTCCTGTTTCTGCATTTGCCGACCTCGTTCCTGCCGCTGGAGGATCGCGGGATGTTCACCACCTCGGTCCAGTTGCCGAGCGGCAGCACCCAGCAGCAGACGCTGAAGGTGGTGCAGAAGGCGGAAGATTACTTTCTCAATAACGAGAAGCAGAACGTCGAGTCGGTGTTCGCTACCGTTGGCTCCGGCCCCGGCGGCAATGGGCAGAACGTGGCCCGCATGTTCGTTCGTCTCAAAGACTGGGACCAGCGCGACCCGCAAACCGGCACCTCCTTTGCCATTATTGAACGCGCCACCAAAGCGTTTAATCAGATTAACGAAGCGCGGGTTATCGCCAGCAGCCCGCCGGCGATCAGCGGCCTCGGCAGTTCGGCAGGCTTCGATATGGAGCTGGAGGATCATGCCGGGAAGGGGCACGATGCGCTGATGGCGGCGCGCGATACGCTGCTTGAGCTGGCCGGGAAAAATCCGCTGTTGACCCGCGTCCGGCATAACGGGCTCGATGACAGTCCGCAGCTGCAGGTCGATATCGATCAGCGTAAAGCGCAGGCGCTGGGCGTCTCCATTGACGACATCAACGATACGCTGCAAACCGCGTGGGGGTCGAGCTACGTCAACGACTTTATGGATCGCGGCCGGGTAAAGAAAGTCTACGTCCAGGCGGCGGCGAAATACCGGATGCTGCCTGACGATATCAATCTTTGGTACGTGCGCAACAGCAGCGGCACGATGGTGCCATTCTCGGCCTTCGCCACCTCGCGCTGGGAGACCGGCTCGCCGCGGCTGGAGCGCTACAATGGCTACTCAGCGGTCGAGATCGTCGGTGAGGCGGCGCCGGGTATCAGTACCGGTACCGCGATGGACATGATGGAGAAGCTGGCCGCGCAGTTACCCACCGGCTTTGGCCTCGAATGGACCGCCATGTCCTACCAGGAACGCCTCTCTGGCGCTCAGGCGCCGGCCCTGTATGCTATTTCTCTGCTGGTGGTGTTCCTGTGCCTGGCGGCGCTGTACGAGAGCTGGTCGGTGCCGTTCTCGGTGATGCTGGTGGTGCCGCTGGGGGTGATTGGCGCCCTGCTGGCGACCTGGATGCGCGGTCTGGAGAATGACGTGTACTTCCAGGTGGGTCTGTTGACGGTGATCGGCCTGTCGGCGAAAAACGCCATTCTGATCGTCGAGTTCGCCAATGAGCTCAACGAGAAGGGCCAGGATCTGCTCAGCGCCACGCTGTCGGCTTGCCGTCAGCGCCTGCGCCCCATCCTGATGACCTCGCTGGCGTTCATCTTCGGCGTGCTGCCGATGGCGACCAGCACCGGCGCCGGTTCCGGCAGCCAGCATGCGGTCGGCACCGGAGTGATGGGCGGGATGATCTCCGCCACCGTGCTGGCGATCTTTTTCGTGCCGCTGTTCTTTGTGCTGGTGCGTCGCCGTTTTCCGCTAAAGGAGCGTCCGCAATAA", "orf_prot_sequence": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "perc_identity": 41.67}}, "NODE_4_length_367278_cov_42.3139_12 # 14037 # 14456 # 1 # ID=4_12;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.614": {"gnl|BL_ORD_ID|2472|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA6", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2779", "pass_evalue": "n/a", "pass_bitscore": "280", "ARO_accession": "3004111", "ARO_name": "FosA6", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.20667e-101, "bit_score": 283.108, "max_identities": 136, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "match": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVA+WKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQ YKGMVFF+Q", "sequence_from_db": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAIWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQQYKGMVFFDQ", "sequence_from_broadstreet": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAIWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQQYKGMVFFDQ", "dna_sequence_from_broadstreet": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGATCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGTCTGGCCGCCTGCCGCGAACAGCAGTATAAGGGGATGGTGTTTTTTGATCAGTGA", "partial": "0", "query_start": 14037, "query_end": 14453, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 97.84}, "gnl|BL_ORD_ID|98|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA5", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "112", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3003209", "ARO_name": "FosA5", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.79735e-101, "bit_score": 282.337, "max_identities": 136, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "match": "MLSGLNHLTLAVSQLAPSVAFYQQLLGM LHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFF +", "sequence_from_db": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMMLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFAE", "sequence_from_broadstreet": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMMLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFAE", "dna_sequence_from_broadstreet": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGATGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATCTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTAGCGGTCTGGAAGCTGAACCGTAGCGAAGGCGCTTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGTCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGCTGAGTGA", "partial": "0", "query_start": 14037, "query_end": 14453, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 97.84}, "gnl|BL_ORD_ID|786|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA3", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "834", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3002872", "ARO_name": "FosA3", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.2005e-80, "bit_score": 229.18, "max_identities": 110, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFE", "match": "ML GLNHLTLAVS LA S+AFYQQL GM LHA WDSGAYLSCG LWLCLSLD QRR TPP+ESDYTHYAFS++E +FA   A L  AG  VWK NRSEGAS+YFLDPDGHKLELHVG+LAQRLAACRE+PYKGMVFF+", "sequence_from_db": "MLQGLNHLTLAVSDLASSLAFYQQLPGMRLHASWDSGAYLSCGALWLCLSLDEQRRKTPPQESDYTHYAFSVAEEEFAGVVALLAQAGAEVWKDNRSEGASYYFLDPDGHKLELHVGNLAQRLAACRERPYKGMVFFD", "sequence_from_broadstreet": "MLQGLNHLTLAVSDLASSLAFYQQLPGMRLHASWDSGAYLSCGALWLCLSLDEQRRKTPPQESDYTHYAFSVAEEEFAGVVALLAQAGAEVWKDNRSEGASYYFLDPDGHKLELHVGNLAQRLAACRERPYKGMVFFD", "dna_sequence_from_broadstreet": "ATGCTGCAGGGATTGAATCATCTGACGCTGGCGGTCAGCGATCTGGCGTCAAGCCTGGCATTTTATCAGCAGTTACCTGGAATGCGCCTGCACGCCAGCTGGGATAGCGGAGCCTATCTCTCCTGTGGGGCGCTGTGGCTGTGCTTGTCGCTGGATGAGCAGCGGCGTAAAACGCCCCCTCAGGAAAGCGACTATACCCACTACGCCTTCAGCGTGGCGGAAGAAGAGTTTGCCGGGGTGGTGGCTCTGCTGGCGCAGGCGGGGGCTGAGGTATGGAAAGATAACCGCAGTGAAGGGGCGTCTTACTATTTTCTCGACCCTGACGGCCATAAGCTGGAGCTGCATGTGGGGAATCTGGCGCAGCGGCTGGCCGCCTGTCGCGAACGCCCCTACAAGGGGATGGTCTTTTTTGATTGA", "partial": "0", "query_start": 14037, "query_end": 14450, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 79.71}, "gnl|BL_ORD_ID|1869|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA4", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1979", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3003210", "ARO_name": "FosA4", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.42796e-78, "bit_score": 225.713, "max_identities": 109, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFE", "match": "ML GLNHLTLAVS LA S+AFYQ+L GM LHARWDSGAYLSCG LWLCLSLD QRR TP +ESDYTHYAFS++E  FA   A+L  AG  VWK NRSEGAS+YFLDPDGHKLELHVG LAQRLAACRE+PYKGMVFF+", "sequence_from_db": "MLQGLNHLTLAVSDLASSLAFYQRLPGMRLHARWDSGAYLSCGALWLCLSLDAQRRKTPAQESDYTHYAFSVAEEHFAEVVAQLAHAGAEVWKDNRSEGASYYFLDPDGHKLELHVGHLAQRLAACRERPYKGMVFFD", "sequence_from_broadstreet": "MLQGLNHLTLAVSDLASSLAFYQRLPGMRLHARWDSGAYLSCGALWLCLSLDAQRRKTPAQESDYTHYAFSVAEEHFAEVVAQLAHAGAEVWKDNRSEGASYYFLDPDGHKLELHVGHLAQRLAACRERPYKGMVFFD", "dna_sequence_from_broadstreet": "ATGCTGCAGGGATTGAATCATCTGACGCTGGCGGTCAGCGATCTGGCGTCAAGCCTGGCGTTTTATCAGCGGTTACCTGGAATGCGTCTGCACGCCCGTTGGGATAGCGGAGCATATCTTTCCTGCGGGGCGTTGTGGCTATGCTTGTCGCTGGATGCGCAGCGGCGTAAAACGCCCGCTCAGGAAAGCGACTATACCCATTATGCTTTCAGCGTGGCGGAAGAGCACTTTGCCGAGGTGGTCGCCCAGCTGGCGCACGCGGGGGCCGAAGTATGGAAAGACAACCGCAGCGAAGGGGCGTCGTACTATTTTCTCGACCCTGACGGCCATAAGCTGGAACTGCATGTGGGTCATTTGGCACAGCGGCTGGCCGCCTGTCGGGAACGCCCGTACAAGGGGATGGTCTTTTTTGACTGA", "partial": "0", "query_start": 14037, "query_end": 14450, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 78.99}, "gnl|BL_ORD_ID|29|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA2", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "35", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3002804", "ARO_name": "FosA2", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.14464e-73, "bit_score": 211.46, "max_identities": 97, "cvterm_id": "36884", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVF", "match": "ML  LNHLTLAVS L  SV F+ +LLG+TLHARW++GAYL+CGDLW+CLS D  R   PP+ESDYTHYAF+++  DF  F+ +LE AGV VWK N+SEGAS YFLDPDGHKLELHVGSLA RLAACRE+PY GMVF", "sequence_from_db": "MLQSLNHLTLAVSDLQKSVTFWHELLGLTLHARWNTGAYLTCGDLWVCLSYDEARGYVPPQESDYTHYAFTVAAEDFEPFSHKLEQAGVTVWKQNKSEGASFYFLDPDGHKLELHVGSLAARLAACREKPYAGMVF", "sequence_from_broadstreet": "MLQSLNHLTLAVSDLQKSVTFWHELLGLTLHARWNTGAYLTCGDLWVCLSYDEARGYVPPQESDYTHYAFTVAAEDFEPFSHKLEQAGVTVWKQNKSEGASFYFLDPDGHKLELHVGSLAARLAACREKPYAGMVFTSDEA", "dna_sequence_from_broadstreet": "ATGCTGCAATCACTCAACCATCTGACCCTCGCGGTCAGCGACCTGCAAAAAAGCGTTACCTTCTGGCACGAGCTGCTGGGGCTGACGCTGCACGCCCGCTGGAATACCGGGGCCTATCTTACCTGCGGCGATCTGTGGGTCTGCCTGTCCTATGACGAGGCGCGCGGTTACGTGCCGCCGCAGGAGAGCGACTATACCCATTACGCGTTTACCGTTGCGGCGGAAGATTTTGAGCCGTTCTCGCACAAGCTGGAGCAGGCGGGCGTTACCGTCTGGAAGCAAAACAAAAGTGAGGGGGCATCGTTCTATTTTCTCGACCCGGACGGGCACAAGCTGGAGCTGCACGTGGGCAGCCTCGCCGCGCGGCTGGCGGCGTGCCGGGAGAAACCCTATGCCGGAATGGTCTTCACCTCAGACGAGGCTTGA", "partial": "0", "query_start": 14037, "query_end": 14444, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 71.32}}, "NODE_6_length_262587_cov_42.4347_106 # 86156 # 87349 # 1 # ID=6_106;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.562": {"gnl|BL_ORD_ID|2388|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Klebsiella pneumoniae acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "770", "model_id": "2659", "ARO_accession": "3004041", "ARO_name": "Klebsiella pneumoniae acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 380, "bit_score": 738.028, "cvterm_id": "35915", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPI--SGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGV LYQIDPATYQ SYDSAKGDLAKAQAAANMDQLTVKRYQKLLGT+YISQQDYD AVATAQQ+NAAVVAAK AVETARINLAYT+  SP+  +   GKS VTEGALVQNGQTTALATVQQ+DPIYVDVTQSSNDFLRLKQELAD RLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "sequence_from_db": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQ-KSPLRSAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "sequence_from_broadstreet": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQKSPLRSAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTTCCTGTATCAGATCGATCCAGCCACCTATCAAGGCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCCAATATATTAGTCAACAAGACTACGATCCCGCCGTTGCGACGGCGCAACAAAACAATGCCGCCGTGGTCGCGGCGAAAACTGCCGTTGAAACCGCGCGCATCAATTTGGCCTACACCCAAAAGTCACCTCTCCGATCAGCGGCCGGATCGGGTAAATCCCCCGTGACCGAAGGGGCGTTGGTACAGAATGGTCAAACGACCGCCTTGGCAACCGTTCAGCAAGTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGCCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTGGTGACTAATGACGGGCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTTCCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGTGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 95.24, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2389|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Enterobacter cloacae acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "760", "model_id": "2660", "ARO_accession": "3004042", "ARO_name": "Enterobacter cloacae acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 348, "bit_score": 661.759, "cvterm_id": "36884", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQ  PEVG+VTLKS PLQITTELPGRT+AYRIAEVRPQVSGIILKRNF EG D+QAG SLYQIDPATYQASY+SAKGDLAKAQAAA + QLT+ RYQKLLGTKYISQQDYDTA+A AQQ+NAAVVAAKAAVETARINLAYTKVTSPISGRIGKS+VTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELA+G LKQENGKAKVEL+TNDG+K+PQ GTLEFSDVTVDQTTGSITLRAIFPNPD  LLPGMFVRARLEEG NP ALLVPQQGVTRTPRGDAS +VVG  +KVE+R +TA+QAIGDKWLVT+GLK GDRVIVTGLQK++PG QVKAQEV SDDKQQA+    SEQTKS", "sequence_from_db": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQQAPEVGVVTLKSEPLQITTELPGRTNAYRIAEVRPQVSGIILKRNFTEGGDVQAGESLYQIDPATYQASYESAKGDLAKAQAAAKIAQLTLNRYQKLLGTKYISQQDYDTALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVELITNDGIKFPQEGTLEFSDVTVDQTTGSITLRAIFPNPDKNLLPGMFVRARLEEGTNPTALLVPQQGVTRTPRGDASALVVGADNKVEMRNITATQAIGDKWLVTEGLKDGDRVIVTGLQKVRPGAQVKAQEVKSDDKQQASAAGQSEQTKS", "sequence_from_broadstreet": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQQAPEVGVVTLKSEPLQITTELPGRTNAYRIAEVRPQVSGIILKRNFTEGGDVQAGESLYQIDPATYQASYESAKGDLAKAQAAAKIAQLTLNRYQKLLGTKYISQQDYDTALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVELITNDGIKFPQEGTLEFSDVTVDQTTGSITLRAIFPNPDKNLLPGMFVRARLEEGTNPTALLVPQQGVTRTPRGDASALVVGADNKVEMRNITATQAIGDKWLVTEGLKDGDRVIVTGLQKVRPGAQVKAQEVKSDDKQQASAAGQSEQTKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTTTCAGGCAGCTTAGCGCTAACAGGATGTGACGACAAACCGGCTCAACAAGGAGCTCAGCAGGCGCCAGAAGTAGGCGTTGTGACGCTCAAATCTGAACCTCTACAAATCACCACCGAATTACCCGGCCGTACAAATGCTTACCGCATTGCGGAAGTGCGTCCTCAGGTTAGCGGCATTATCCTGAAACGCAACTTCACCGAAGGCGGTGATGTGCAGGCCGGTGAGTCTCTGTATCAGATTGATCCCGCAACCTATCAGGCGTCTTATGAAAGCGCGAAAGGCGATCTGGCTAAAGCGCAGGCCGCGGCTAAAATTGCCCAGCTGACGCTGAACCGCTATCAAAAACTGCTCGGTACCAAGTACATCAGTCAGCAGGATTACGATACCGCCCTGGCGGATGCCCAGCAGGCTAACGCCGCCGTGGTGGCAGCCAAAGCGGCCGTCGAAACCGCGCGCATTAACCTGGCCTATACCAAAGTGACCTCCCCTATCAGCGGTCGTATTGGTAAATCTTCCGTCACGGAAGGGGCTCTGGTGCAAAACGGTCAGACCACTGCGCTGGCGACCGTGCAGCAGCTCGATCCGATCTATGTTGACGTCACGCAGTCCAGCAATGATTTCCTGCGCCTGAAACAGGAGTTGGCTAACGGCACCCTGAAACAGGAAAACGGCAAAGCCAAAGTGGAGCTGATTACCAACGACGGTATCAAGTTCCCGCAGGAAGGGACGCTGGAATTCTCTGACGTGACGGTCGACCAGACCACCGGTTCCATCACCTTACGTGCGATTTTCCCGAACCCTGACAAAAATCTGCTGCCAGGTATGTTCGTTCGCGCACGTCTGGAAGAAGGAACGAATCCAACCGCCCTTCTGGTTCCACAGCAGGGTGTGACCCGTACGCCACGCGGCGATGCGAGCGCACTGGTTGTTGGGGCTGATAACAAAGTCGAAATGCGCAACATCACCGCCACCCAGGCGATTGGGGATAAATGGCTGGTGACGGAAGGTCTGAAAGATGGCGATCGCGTGATTGTTACTGGTTTGCAAAAAGTTCGTCCTGGCGCGCAGGTTAAAGCACAGGAAGTGAAATCTGACGATAAACAACAAGCTTCGGCCGCTGGCCAGTCAGAACAAACCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 87.66}, "gnl|BL_ORD_ID|2390|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Escherichia coli acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "model_id": "2661", "ARO_accession": "3004043", "ARO_name": "Escherichia coli acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 337, "bit_score": 656.366, "cvterm_id": "36849", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRG TPLAVVLMLSGSLALTGCDDK AQQG Q MP VG+VT+K+ PLQITTELPGRTSAYRIAEVRPQVSGIILKRNF EGSDI+AGVSLYQIDPATYQA+YDSAKGDLAKAQAAAN+ QLTV RYQKLLGT+YIS+Q+YD A+A AQQ+NAAV AAKAAVETARINLAYTKVTSPISGRIGKS VTEGALVQNGQ TALATVQQLDPIYVDVTQSSNDFLRLKQELA+G LKQENGKAKV L+T+DG+K+PQ GTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEG+NP+A+LVPQQGVTRTPRGDA+V+VVG  DKVE R + ASQAIGDKWLVT+GLK+GDRV+++GLQK++PGVQVKAQEV +D+ QQAA  A  EQ+KS", "sequence_from_db": "MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS", "sequence_from_broadstreet": "MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTTACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCCCTAACAGGATGTGACGACAAACAGGCCCAACAAGGTGGCCAGCAGATGCCCGCCGTTGGCGTAGTAACAGTCAAAACTGAACCTCTGCAGATCACAACCGAGCTTCCGGGTCGCACCAGTGCCTACCGGATCGCAGAAGTTCGTCCTCAAGTTAGCGGGATTATCCTGAAGCGTAATTTCAAAGAAGGTAGCGACATCGAAGCAGGTGTCTCTCTCTATCAGATTGATCCTGCGACCTATCAGGCGACATACGACAGTGCGAAAGGTGATCTGGCGAAAGCCCAGGCTGCAGCCAATATCGCGCAATTGACGGTGAATCGTTATCAGAAACTGCTCGGTACTCAGTACATCAGTAAGCAAGAGTACGATCAGGCTCTGGCTGATGCGCAACAGGCGAATGCTGCGGTAACTGCGGCGAAAGCTGCCGTTGAAACTGCGCGGATCAATCTGGCTTACACCAAAGTCACCTCTCCGATTAGCGGTCGCATTGGTAAGTCGAACGTGACGGAAGGCGCATTGGTACAGAACGGTCAGGCGACTGCGCTGGCAACCGTGCAGCAACTTGATCCGATCTACGTTGATGTGACCCAGTCCAGCAACGACTTCCTGCGCCTGAAACAGGAACTGGCGAATGGCACGCTGAAACAAGAGAACGGCAAAGCCAAAGTGTCACTGATCACCAGTGACGGCATTAAGTTCCCGCAGGACGGTACGCTGGAATTCTCTGACGTTACCGTTGATCAGACCACTGGGTCTATCACCCTACGCGCTATCTTCCCGAACCCGGATCACACTCTGCTGCCGGGTATGTTCGTGCGCGCACGTCTGGAAGAAGGGCTTAATCCAAACGCTATTTTAGTCCCGCAACAGGGCGTAACCCGTACGCCGCGTGGCGATGCCACCGTACTGGTAGTTGGCGCGGATGACAAAGTGGAAACCCGTCCGATCGTTGCAAGCCAGGCTATTGGCGATAAGTGGCTGGTGACAGAAGGTCTGAAAGCAGGCGATCGCGTAGTAATAAGTGGGCTGCAGAAAGTGCGTCCTGGTGTCCAGGTAAAAGCACAAGAAGTTACCGCTGATAATAACCAGCAAGCCGCAAGCGGTGCTCAGCCTGAACAGTCCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 84.89}, "gnl|BL_ORD_ID|1357|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "acrE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "675", "model_id": "1445", "ARO_accession": "3000499", "ARO_name": "AcrE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 257, "bit_score": 514.227, "cvterm_id": "36849", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA", "match": "M K+     L   +++S +L + GC+DK  ++     P+V +  +K+APL++ TELPGRT+AYRIAEVRPQVSGI+L RNF EGSD+QAG SLYQIDPATYQA+YDSAKG+LAK++AAA +  LTVKRY  L+GTKYISQQ+YD A+A A+Q++AAV+AAKA VE+ARINLAYTKVT+PISGRIGKSTVTEGALV NGQTT LATVQQLDPIYVDVTQSSNDF+RLKQ +  G L +EN  + VELV  +G  YP  GTL+FSDVTVD++TGSITLRA+FPNP HTLLPGMFVRAR++EG+ PDA+L+PQQGV+RTPRGDA+V++V +  +VE R V ASQAIGDKWL+++GLKSGD+VIV+GLQK +PG QVKA", "sequence_from_db": "MTKHARFFLLPSFILISAAL-IAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATSNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKA", "sequence_from_broadstreet": "MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATSNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADTASK", "dna_sequence_from_broadstreet": "ATGACGAAACATGCCAGGTTTTTCCTCCTGCCCTCCTTTATTCTGATCTCCGCGGCTTTAATCGCCGGTTGTAACGATAAGGGAGAAGAGAAAGCTCACGTCGGTGAACCGCAGGTTACCGTTCATATTGTAAAAACGGCCCCGTTAGAAGTTAAGACTGAATTACCAGGCCGCACCAATGCTTATCGTATAGCCGAAGTTCGCCCACAGGTTAGCGGGATCGTACTGAATCGCAATTTCACTGAAGGCAGCGATGTGCAAGCAGGCCAGTCCCTGTACCAGATCGATCCCGCGACCTATCAGGCAAATTATGACAGCGCGAAAGGCGAACTGGCGAAAAGTGAAGCCGCCGCCGCCATCGCGCATTTGACGGTAAAACGTTACGTTCCGCTCGTGGGTACGAAATACATCAGCCAGCAGGAGTACGACCAGGCCATTGCTGATGCTCGTCAGGCCGATGCCGCCGTGATTGCCGCAAAAGCCACAGTCGAAAGCGCTCGCATCAATCTTGCTTATACCAAAGTCACTGCGCCAATTAGCGGACGTATCGGCAAATCGACTGTGACCGAAGGCGCTCTTGTCACTAATGGGCAAACGACTGAACTGGCGACTGTCCAGCAGCTCGATCCTATCTACGTTGATGTGACCCAATCCAGCAACGATTTTATGAGGCTGAAGCAATCCGTAGAGCAAGGAAATTTGCATAAGGAAAACGCCACCAGCAACGTAGAGTTGGTCATGGAAAACGGTCAAACCTATCCCCTGAAAGGTACGCTGCAATTCTCCGATGTGACCGTTGATGAAAGCACCGGCTCCATAACCCTACGTGCTGTCTTCCCTAACCCGCAACATACGCTTTTGCCGGGTATGTTTGTGCGTGCACGGATTGATGAAGGCGTCCAACCTGACGCCATTCTTATCCCGCAACAAGGCGTTAGCCGCACACCGCGTGGTGATGCAACCGTGCTGATTGTTAACGATAAAAGTCAGGTTGAAGCGCGCCCTGTCGTTGCCAGTCAGGCGATTGGCGATAAATGGTTGATTAGTGAAGGACTGAAATCTGGCGATCAAGTCATTGTCAGCGGCCTGCAAAAAGCGCGTCCGGGAGAGCAGGTTAAAGCCACTACCGATACCCCCGCAGATACTGCATCGAAGTAA", "partial": "0", "query_start": 86156, "query_end": 87280, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 68.53}, "gnl|BL_ORD_ID|1797|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "675", "model_id": "1903", "ARO_accession": "3000795", "ARO_name": "mdtE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35930": {"category_aro_accession": "0000011", "category_aro_cvterm_id": "35930", "category_aro_name": "cloxacillin", "category_aro_description": "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections.", "category_aro_class_name": "Antibiotic"}, "35973": {"category_aro_accession": "0000056", "category_aro_cvterm_id": "35973", "category_aro_name": "oxacillin", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.20033e-143, "max_identities": 208, "bit_score": 410.609, "cvterm_id": "36839", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA----QEVASDDKQQ", "match": "MN+ R    L + L+  G++ LT CDDK A+  A   PEVG+VTL    + + +ELPGRT  Y +AE+RPQV GII+KRNF+EG  +  G SLYQIDPA  QA  +SAKG LAKA + A+  ++T  R   LL T Y+S+QDYDTA     ++ A V  AKAAVE A INL Y  VTSPI+G  GKS+VT GALV   Q  +L TVQ+LDPIYVD+TQS  DFLR+K+E+A G++KQ  G   V+L   +G +Y Q+GTL+FSD TVD+TTGS+TLRAIFPNP+  LLPGM+V A ++EG   + LLVPQ+GVT   +G A+ +++ + D V++R++ AS+AIGD+W+VT GL++GDRVIV+GLQ+I+PG++ +A    QE AS + +Q", "sequence_from_db": "MNRRR---KLLIPLLFCGAM-LTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ", "sequence_from_broadstreet": "MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ", "dna_sequence_from_broadstreet": "ATGAACAGAAGAAGAAAGCTGTTAATACCGTTGTTATTCTGCGGCGCGATGCTCACCGCCTGCGATGACAAATCGGCGGAAAACGCCGCCGCCATGACGCCTGAGGTCGGTGTCGTCACACTCTCCCCCGGTTCGGTCAATGTGTTGAGCGAATTGCCCGGTAGAACCGTTCCTTATGAAGTTGCCGAGATACGTCCCCAGGTGGGCGGTATTATCATTAAACGCAACTTTATCGAAGGCGATAAAGTGAACCAGGGCGATTCGCTGTATCAGATTGATCCTGCACCTTTACAGGCCGAGCTAAACTCCGCCAAAGGCTCGCTGGCGAAAGCGCTCTCTACCGCCAGCAATGCCCGCATCACCTTTAACCGCCAGGCATCGTTGCTGAAGACCAACTACGTTAGCCGTCAGGATTACGACACCGCGCGCACCCAGTTGAATGAAGCAGAAGCCAATGTCACCGTCGCCAAAGCGGCTGTTGAACAGGCGACGATCAATCTGCAATACGCGAATGTCACCTCGCCGATTACGGGCGTCAGCGGGAAATCGTCGGTGACCGTCGGCGCACTCGTTACCGCTAATCAGGCAGATTCGCTGGTTACCGTACAACGTCTGGACCCGATTTATGTCGATCTCACGCAGTCGGTGCAAGATTTCTTACGCATGAAAGAAGAGGTCGCCAGTGGGCAAATCAAACAGGTTCAGGGCAGTACGCCAGTACAGCTCAATCTGGAAAATGGTAAACGCTACAGCCAGACCGGCACGCTGAAATTCTCCGACCCGACAGTGGATGAAACCACGGGCTCCGTGACGTTACGGGCGATTTTCCCCAACCCAAATGGTGACTTGCTGCCTGGCATGTACGTCACGGCATTAGTGGATGAAGGTAGCCGCCAGAATGTATTACTGGTGCCGCAGGAAGGCGTCACCCACAACGCCCAGGGTAAAGCAACGGCGCTCATTCTGGATAAAGACGATGTCGTGCAGCTACGCGAAATTGAAGCCAGCAAAGCCATCGGCGACCAGTGGGTCGTCACCTCTGGCTTGCAGGCTGGCGATCGGGTGATCGTTTCCGGTTTGCAACGCATTCGTCCGGGTATCAAAGCACGAGCAATTTCCTCCAGCCAGGAAAACGCCAGCACCGAATCGAAACAATAA", "partial": "0", "query_start": 86156, "query_end": 87310, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 53.47}, "gnl|BL_ORD_ID|451|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98469e-140, "max_identities": 217, "bit_score": 400.979, "cvterm_id": "36804", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQE-NGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK---AQEVASDDKQQAA", "match": "M +   +  L   L+++ S AL+GC    A   AQ  PEVGIVTL++  + + TELPGRT+A+RIAEVRPQV+GIILKR F EGSD++AG  LYQIDPATY+A Y SA+ +LA  Q  A       +RY+ L+  + +S+Q Y  A       NAA + +KAAVE ARINL YTKV SPISGRIG+S VTEGALV NGQ  A+ATVQQLDPIYVDVTQ S   LRL++ELA G+L++  +  AKV L   DG +YP  G LEFS+V+VD+ TGS+T+RA+FPNP++ LLPGMFV A+L+EG+   A+L PQQGVTR  +G A+ +VV   +KVE+R + A + IGDKWLVT+GL +GD++I  GLQ ++PGV+VK   A+ VAS  K  AA", "sequence_from_db": "MQRTPAMRVLVPALLVAIS-ALSGCGKSEAPPPAQ-TPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQA-------QRYKLLVADQAVSKQQYADA-------NAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAA", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 86156, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 55.5}, "gnl|BL_ORD_ID|450|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98469e-140, "max_identities": 217, "bit_score": 400.979, "cvterm_id": "36804", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQE-NGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK---AQEVASDDKQQAA", "match": "M +   +  L   L+++ S AL+GC    A   AQ  PEVGIVTL++  + + TELPGRT+A+RIAEVRPQV+GIILKR F EGSD++AG  LYQIDPATY+A Y SA+ +LA  Q  A       +RY+ L+  + +S+Q Y  A       NAA + +KAAVE ARINL YTKV SPISGRIG+S VTEGALV NGQ  A+ATVQQLDPIYVDVTQ S   LRL++ELA G+L++  +  AKV L   DG +YP  G LEFS+V+VD+ TGS+T+RA+FPNP++ LLPGMFV A+L+EG+   A+L PQQGVTR  +G A+ +VV   +KVE+R + A + IGDKWLVT+GL +GD++I  GLQ ++PGV+VK   A+ VAS  K  AA", "sequence_from_db": "MQRTPAMRVLVPALLVAIS-ALSGCGKSEAPPPAQ-TPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQA-------QRYKLLVADQAVSKQQYADA-------NAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAA", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 86156, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 55.5}, "gnl|BL_ORD_ID|263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "smeD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "284", "ARO_accession": "3003055", "ARO_name": "smeD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40053e-125, "max_identities": 195, "bit_score": 364.385, "cvterm_id": "37076", "query": "LTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "+ P A+ L ++ ++A  G   +  +QG     +V +VTLKS  + +T ELPGRT+A+ +AEVRPQV+GI+ KR F EG  ++AG  LYQ+D A+Y+A  ++A+  LA+A+A AN  +L+ KR  +L     +SQQD + AVA  +Q+ A V AAKA+++ A + L Y ++T+PISGRIGKS+VT+GALV  GQ  ALATVQQLDPIYVD+TQSS + L+L++ELA GRL Q+N    V ++  DG  +   GTLEFS+V+VD TTGS  LR    NPD  L+PGM+VRA +  G+  DA+LVP QG+ R P+GD + MVVG+ +KVEVR V  S+ +GDKWLV DGLK+GD+VIV GLQKI PG+ VKA E", "sequence_from_db": "IRPFALSLAIAATVAACGGQPQAPEQGPG---DVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRL-QDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATE", "sequence_from_broadstreet": "MLLSRIRPFALSLAIAATVAACGGQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGDAPAKPAAAAQPAAPAGDAK", "dna_sequence_from_broadstreet": "ATGTTGCTGAGCCGAATCCGACCCTTTGCACTGTCGCTGGCAATCGCCGCGACCGTGGCTGCCTGCGGCGGCCAACCCCAGGCCCCCGAGCAGGGCCCGGGTGACGTCACCGTGGTCACGCTGAAGTCCGAGACCGTGGGCCTGACCCGCGAACTGCCGGGCCGTACCAATGCCTTCCTGGTCGCCGAAGTGCGCCCGCAGGTCAATGGCATCGTGGCCAAGCGCCTGTTTACCGAGGGCGGCATGGTCAAGGCCGGCGAGCCGCTGTACCAGCTCGACGATGCCAGCTACCGGGCCCAGGCCAACAACGCCCGCGCCCAGCTGGCCCGCGCCGAAGCCACCGCCAATGCCGCGCGCCTGAGTGCCAAGCGCATCACCGAGCTGGCCAAGGTCGATGCGGTCAGCCAGCAGGACCTGGAGAACGCCGTCGCCGCGCAGAAGCAGGCCGAGGCCGACGTCGGTGCCGCCAAGGCCTCGCTGGATGCGGCCAACGTCACCCTGGGCTACGCCCGCATCACCGCGCCGATCAGCGGCCGCATCGGCAAGTCCAGCGTCACCCAGGGTGCGCTGGTCAGCGCCGGCCAGGCCAACGCACTGGCCACCGTGCAGCAGCTGGACCCGATCTATGTCGACCTGACCCAGTCCTCGGCCGAGCTGCTGCAGCTGCGCCGCGAACTGGCCGCCGGCCGCCTGCAGGACAACCAGACCCTGCCGGTCAGCATCCTGATGGAAGACGGCAGCACCTTCGAGCACAAGGGCACTCTGGAGTTCTCCGAAGTCAGCGTTGATCCGACCACCGGCAGCTTCGGCCTGCGCGTGAAGGTGGACAACCCGGACGGCCTGCTGATGCCGGGCATGTACGTGCGTGCGGTGATCGGCGGCGGCGTGCGCAGCGACGCGGTGCTGGTGCCGATGCAGGGCATCGCGCGCGATCCGAAGGGCGACACCACCGCGATGGTGGTCGGCAAGGACAACAAGGTCGAAGTGCGCCCGGTCAAGGTCAGCCGCACGGTCGGCGACAAGTGGCTGGTCGAGGACGGCCTGAAGGCCGGTGACAAGGTCATCGTCGAAGGCCTGCAGAAGATCGGCCCCGGCATGCCGGTCAAGGCCACCGAGAAGGGCGACGCACCGGCCAAGCCGGCGGCAGCCGCCCAGCCTGCCGCCCCGGCCGGCGACGCGAAGTAA", "partial": "0", "query_start": 86174, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 52.56}, "gnl|BL_ORD_ID|763|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "805", "ARO_accession": "3000800", "ARO_name": "MexC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03515e-109, "max_identities": 171, "bit_score": 322.398, "cvterm_id": "36752", "query": "LSGSLALTGCDDKPA---QQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQ", "match": "L+ ++AL GC   PA   Q+ A+ +  V ++T+++ PL +++ELPGR    R+AEVR +V+GI++++ F EG+D++AG  L+QIDPA  +A+   A+G+LA+ +A     Q  V+RY+ L+  + +SQQD+DTA A  + + AA  +A+A +ETAR+NL Y  VT+PISGRIG++ VTEGALV  G+ T +A +QQLDPIY D TQ++ + LRL+  L  G L    G ++   +  +G  Y + G L+F+DV VD+ TG I LR  F NPD  LLPGM+VR R  +GI+  A+LVPQ+ V R+  G A VMVVG  ++ E R V      G +W +T+GL+ GDRVIV GL  ++PGV++    V   D  QA   +P+ Q", "sequence_from_db": "LAMAIALAGCG--PAEERQEAAEMVLPVEVLTVQAEPLALSSELPGRIEPVRVAEVRARVAGIVVRKRFEEGADVKAGDLLFQIDPAPLKAAVSRAEGELARNRAVLFEAQARVRRYEPLVKIQAVSQQDFDTATADLRSAEAATRSAQADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGEATLMARIQQLDPIYADFTQTAAEALRLRDALKKGTLA--AGDSQALTLRVEGTPYERQGALQFADVAVDRGTGQIALRGKFANPDGVLLPGMYVRVRTPQGIDNQAILVPQRAVHRSSDGSAQVMVVGADERAESRSVGTGVMQGSRWQITEGLEPGDRVIVGGLAAVQPGVKI----VPKPDGAQAQAQSPAPQ", "sequence_from_broadstreet": "MADLRAIGRIGALAMAIALAGCGPAEERQEAAEMVLPVEVLTVQAEPLALSSELPGRIEPVRVAEVRARVAGIVVRKRFEEGADVKAGDLLFQIDPAPLKAAVSRAEGELARNRAVLFEAQARVRRYEPLVKIQAVSQQDFDTATADLRSAEAATRSAQADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGEATLMARIQQLDPIYADFTQTAAEALRLRDALKKGTLAAGDSQALTLRVEGTPYERQGALQFADVAVDRGTGQIALRGKFANPDGVLLPGMYVRVRTPQGIDNQAILVPQRAVHRSSDGSAQVMVVGADERAESRSVGTGVMQGSRWQITEGLEPGDRVIVGGLAAVQPGVKIVPKPDGAQAQAQSPAPQQ", "dna_sequence_from_broadstreet": "ATGGCTGATTTGCGTGCAATAGGAAGGATCGGGGCGTTGGCTATGGCCATCGCGTTGGCGGGTTGTGGGCCGGCGGAAGAGCGACAGGAGGCCGCCGAAATGGTGTTGCCGGTGGAGGTCCTGACGGTGCAGGCCGAGCCCCTGGCGCTGAGTTCGGAACTGCCTGGGCGGATCGAACCGGTGCGGGTCGCCGAGGTGCGCGCGCGGGTGGCCGGCATCGTCGTGCGGAAGCGCTTCGAGGAGGGCGCCGACGTCAAGGCTGGCGACCTGCTGTTCCAGATCGATCCGGCACCGCTGAAGGCTGCGGTGTCGCGCGCCGAGGGTGAGCTGGCGCGGAACCGCGCGGTGCTGTTCGAGGCGCAGGCGCGGGTGCGTCGCTACGAGCCGCTGGTGAAGATCCAGGCGGTCAGCCAGCAGGACTTCGATACCGCCACCGCCGACCTGCGCAGCGCCGAGGCGGCGACCCGCTCGGCCCAGGCCGACCTGGAGACCGCGCGCCTGAACCTCGGCTACGCCTCGGTCACTGCGCCGATCTCCGGGCGCATCGGCCGCGCGCTGGTGACCGAGGGCGCGCTGGTCGGGCAGGGCGAGGCGACGCTGATGGCGCGCATCCAGCAGCTCGATCCGATCTATGCGGATTTCACCCAGACCGCGGCCGAGGCCCTGCGCCTGCGCGACGCCCTGAAGAAAGGCACCTTGGCCGCCGGCGACAGCCAGGCGCTGACCCTGCGCGTCGAAGGGACGCCCTACGAGCGCCAGGGCGCGTTGCAGTTCGCCGACGTGGCGGTGGATCGCGGCACCGGCCAGATCGCCCTGCGCGGCAAGTTCGCCAACCCCGACGGGGTCCTGCTGCCGGGCATGTACGTGCGCGTACGTACGCCCCAGGGCATCGACAACCAGGCGATCCTGGTGCCGCAACGGGCCGTGCACCGCTCCAGCGACGGCAGCGCCCAGGTGATGGTGGTGGGCGCCGACGAGCGCGCCGAGTCGCGCAGCGTCGGTACCGGCGTCATGCAGGGTTCGCGCTGGCAGATCACCGAGGGCCTGGAGCCGGGTGACCGGGTCATAGTCGGCGGCCTGGCTGCGGTGCAGCCGGGGGTGAAGATCGTGCCGAAGCCGGATGGTGCCCAGGCGCAAGCCCAGTCACCTGCGCCGCAACAGTAA", "partial": "0", "query_start": 86201, "query_end": 87337, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 44.76}, "gnl|BL_ORD_ID|1384|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "1471", "ARO_accession": "3000780", "ARO_name": "adeI", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.28264e-105, "max_identities": 180, "bit_score": 314.694, "cvterm_id": "35531", "query": "PLAVVLMLSGSLALTGC----DDKPAQQGAQHMP--EVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVK--RYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQ--EVASDDKQQAAGNA", "match": "P      L+ S+AL GC    D+K     AQ MP  EVG++  +   ++ + EL GRTSAY+I+EVRPQ SG+ILKR F EGS ++ G +LY++D  T +A+ ++AK  L + QA  N+  L  K  RY++L+ +  +S+Q+YD  +     + A V AAKA V  A ++L Y+ + SPISG+ G+S+VT GALV   QT  L T+QQLDPIYVD+ QSS + LRL+Q+L+ G L   N   KV+L   DG  YP  G L FSD +V+Q TG+ITLRA+F NP+H LLPGM+  A++ +G+ P+A L+PQ  +TR P G A  M+V     VE R V  S   G  W+VT+GLK+GD+VIV G+ K+K G +V A+  +    + Q AA NA", "sequence_from_db": "PALTACALATSIALVGCSKGSDEKQQAAAAQKMPPAEVGVIVAQPQSVEQSVELSGRTSAYQISEVRPQTSGVILKRLFAEGSYVREGQALYELDSRTNRATLENAKASLLQQQA--NLASLRTKLNRYKQLVSSNAVSKQEYDDLLGQVNVAEAQVAAAKAQVTNANVDLGYSTIRSPISGQSGRSSVTAGALVTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSN-NTKVKLKLEDGSTYPIEGQLAFSDASVNQDTGTITLRAVFSNPNHLLLPGMYTTAQIVQGVVPNAYLIPQAAITRLPTGQAVAMLVNAKGVVESRPVETSGVQGQNWIVTNGLKAGDKVIVDGVAKVKEGQEVSAKPYQAQPANSQGAAPNA", "sequence_from_broadstreet": "MMSAKLWAPALTACALATSIALVGCSKGSDEKQQAAAAQKMPPAEVGVIVAQPQSVEQSVELSGRTSAYQISEVRPQTSGVILKRLFAEGSYVREGQALYELDSRTNRATLENAKASLLQQQANLASLRTKLNRYKQLVSSNAVSKQEYDDLLGQVNVAEAQVAAAKAQVTNANVDLGYSTIRSPISGQSGRSSVTAGALVTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSNNTKVKLKLEDGSTYPIEGQLAFSDASVNQDTGTITLRAVFSNPNHLLLPGMYTTAQIVQGVVPNAYLIPQAAITRLPTGQAVAMLVNAKGVVESRPVETSGVQGQNWIVTNGLKAGDKVIVDGVAKVKEGQEVSAKPYQAQPANSQGAAPNAAKPAQSGKPQAEQKAASNA", "dna_sequence_from_broadstreet": "ATGATGTCGGCTAAGCTTTGGGCACCAGCCCTTACTGCTTGCGCATTAGCAACAAGTATCGCGCTTGTTGGTTGTAGCAAAGGCTCCGATGAGAAACAGCAAGCTGCTGCTGCTCAGAAAATGCCGCCTGCAGAAGTAGGTGTTATTGTTGCTCAACCACAAAGTGTTGAACAAAGCGTTGAGCTTTCAGGCCGTACTTCAGCATATCAAATTTCTGAAGTTCGTCCTCAAACAAGTGGCGTGATTTTAAAACGTTTATTTGCTGAAGGAAGCTATGTTCGTGAAGGTCAGGCGCTTTATGAGCTCGACTCTAGAACGAACCGTGCAACGTTAGAAAATGCAAAAGCATCACTCCTACAACAACAGGCAAATCTAGCTTCACTACGTACCAAGTTAAATCGTTATAAACAACTTGTTTCTAGTAATGCTGTGTCTAAACAGGAATATGATGACTTACTTGGTCAAGTCAATGTTGCAGAAGCACAAGTTGCAGCAGCTAAGGCTCAAGTAACAAATGCAAATGTAGATCTTGGTTATTCTACAATTCGCTCTCCTATTTCTGGCCAATCTGGTCGTTCTTCAGTAACGGCTGGTGCTTTGGTTACTGCAAACCAGACTGACCCGTTGGTAACGATTCAACAATTAGATCCTATCTATGTTGATATTAATCAGTCTAGTGCTGAGTTATTGCGTTTACGTCAACAACTAAGCAAAGGCAGTTTAAATAACAGTAACAACACGAAAGTAAAATTAAAGCTTGAAGATGGTTCTACCTATCCAATCGAAGGGCAACTTGCTTTCTCTGACGCTTCTGTAAACCAAGATACAGGAACAATTACATTACGTGCCGTATTCTCTAACCCGAATCATTTATTGCTTCCGGGTATGTATACCACTGCGCAAATTGTTCAGGGCGTTGTTCCAAATGCTTACCTGATTCCTCAAGCTGCCATTACTCGTTTACCTACAGGACAAGCTGTAGCGATGCTTGTTAATGCTAAAGGGGTTGTTGAGAGCCGTCCTGTTGAAACCTCTGGTGTTCAAGGACAAAACTGGATTGTGACTAACGGCTTAAAAGCCGGCGATAAAGTCATTGTTGATGGTGTTGCCAAAGTTAAAGAAGGGCAAGAAGTATCAGCAAAACCTTATCAAGCTCAACCAGCAAACTCTCAAGGTGCAGCACCAAATGCTGCGAAACCGGCTCAATCAGGTAAACCTCAAGCAGAACAGAAAGCAGCTTCAAATGCATAA", "partial": "0", "query_start": 86180, "query_end": 87325, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 45.92}, "gnl|BL_ORD_ID|1417|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "smeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1507", "ARO_accession": "3003051", "ARO_name": "smeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.41339e-101, "max_identities": 162, "bit_score": 302.753, "cvterm_id": "37076", "query": "AQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA", "match": "A  MPEVG++   + PL +   LPGR   + I+EVRPQ+ G+I +R F EG  ++AG  LYQ+DPA YQA++D+A+G LA+A+A     Q   +R + L+     S+QD D A +  +Q+ A V+AA+AA++ ARINL YT+VT+PI GRIG S+VT GALV  GQ TAL T+Q+LDP+Y+DVTQSS   L L++ L  G +K  +GKA+V+++  DG  Y   GTLEF    VD  TG++ LRA+ PNPD  LLPGM+++A L    +  ALLVPQ+ V R  RG+  + ++   D V  R+V+  Q +G++W +T GLK+G+RVIV+    +  G QVKA", "sequence_from_db": "APAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQLLYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDGRIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTGNVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVSNGSAVSLGQQVKA", "sequence_from_broadstreet": "MSLLRPLSRSPRPLLLPLLLALAACSADRTDAPAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQLLYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDGRIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTGNVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVSNGSAVSLGQQVKAVAPTTAQLAAMPAVDPNGNTDEKSH", "dna_sequence_from_broadstreet": "ATGTCTCTCCTGCGCCCGCTGTCCCGTTCCCCGCGTCCCCTGCTGTTGCCCCTGCTGCTGGCCCTGGCGGCCTGTTCGGCGGACAGGACCGACGCCCCGGCCATGCCCGAAGTGGGCGTCATCATCGCCAGCGCGCAGCCGCTGGCACTCCAGCAGACCTTGCCCGGCCGTGCCGTGCCGTTCGAGATCTCCGAGGTGCGGCCGCAGATCGGCGGCCTGATCCGCCAGCGGTTGTTCACCGAAGGCCAGCAGGTCAAGGCAGGGCAGCTGCTGTACCAGGTCGACCCGGCACCGTACCAGGCGGCCTTCGATACCGCCCGCGGGCAGCTGGCGCAGGCCGAGGCCACCGTGTTGTCGGCACAGCCGAAGGCCGAGCGTACCCGCGCGCTGGTGAGCATGGATGCAGCCAGCAAGCAGGACGCCGACGATGCCACCTCGGCGTTGAAGCAGGCGCAGGCCAACGTGATTGCCGCGCGCGCTGCATTGCAGGCTGCCCGCATCAACCTCGACTACACCCGGGTGACCGCCCCCATCGACGGTCGCATCGGCACCTCCAGCGTCACCGCCGGCGCGCTGGTCGCGGCCGGCCAGGATACGGCGTTGACCACCATCCAGCGGCTGGACCCGGTGTACCTGGATGTCACCCAGTCCAGCACGCAGATGCTGGCGCTGCGCAAGCGGCTCGATGCGGGCCTAGTGAAGGCCATCGATGGCAAGGCACAGGTTAAGGTGCTGCTGGAGGACGGCAGCACCTACGCGCATGAAGGCACGTTGGAGTTCGTCGGCAGCGCAGTGGATCCGGGCACCGGAAACGTGAAGCTGCGCGCGGTCATTCCGAACCCGGACGGCCTGCTGTTGCCGGGCATGTACCTGAAGGCGGTGCTGCCGATGGCCACCGACGCGCGTGCCCTGCTGGTGCCGCAGAAGGCAGTGGTGCGCAACGAACGCGGCGAACCGCTGCTGCGCCTGCTCGACGCCAAGGATCATGTGGTCGAGCGCCGCGTCAGCACCGGCCAGGTGGTCGGTAACCAGTGGCAGATCACCAGCGGCCTCAAGGCTGGCGAACGGGTGATCGTCAGCAACGGCAGCGCGGTATCGCTCGGTCAGCAGGTGAAAGCGGTGGCGCCCACGACGGCGCAGTTGGCGGCGATGCCGGCGGTCGATCCGAACGGCAACACCGACGAAAAGTCGCACTGA", "partial": "0", "query_start": 86255, "query_end": 87280, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 47.37}, "gnl|BL_ORD_ID|1260|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mtrC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "790", "model_id": "1340", "ARO_accession": "3000810", "ARO_name": "mtrC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.91955e-92, "max_identities": 151, "bit_score": 279.641, "cvterm_id": "39597", "query": "PEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQ--KIKPGVQVKAQEVASDDKQQAA", "match": "P VG+VT+    + +T ELPGR  + R A+VR QV GII KR F EGS ++AG  LYQID +TY+A  +SA+  LA AQA        + RY+ L+  + +S+Q+YD AV   + + A V AA+AA+++A I+L  +++T+PISG IG+S V+EG L+  G  T LAT++Q +P+YV+VTQS+++ ++L++++A+G+L   +G   V +  +DG  YP+ G L F+D  V+++TG ITLRA  PN  + L+PG++VR  +++    +A +VPQQ VTR  +   +VM+V     +E R+VT +Q  G  W+VT GLK GD+V+V G+    I    +V  +E AS + Q AA", "sequence_from_db": "PVVGVVTVHPQTVALTVELPGRLESLRTADVRAQVGGIIQKRLFQEGSYVRAGQPLYQIDSSTYEAGLESARAQLATAQATLAKADADLARYKPLVAAEAVSRQEYDAAVTAKRSAEAGVKAAQAAIKSAGISLNRSRITAPISGFIGQSKVSEGTLLNAGDATVLATIRQTNPMYVNVTQSASEVMKLRRQIAEGKLLAADGVIAVGIKFDDGTVYPEKGRLLFADPAVNESTGQITLRAAVPNDQNILMPGLYVRVLMDQVAVDNAFVVPQQAVTRGAKD--TVMIVNAQGGMEPREVTVAQQQGTNWIVTSGLKDGDKVVVEGISIAGITGAKKVTPKEWASSENQAAA", "sequence_from_broadstreet": "MAFYAFKAMRAAALAAAVALVLSSCGKGGDAAQGGQPAGREAPAPVVGVVTVHPQTVALTVELPGRLESLRTADVRAQVGGIIQKRLFQEGSYVRAGQPLYQIDSSTYEAGLESARAQLATAQATLAKADADLARYKPLVAAEAVSRQEYDAAVTAKRSAEAGVKAAQAAIKSAGISLNRSRITAPISGFIGQSKVSEGTLLNAGDATVLATIRQTNPMYVNVTQSASEVMKLRRQIAEGKLLAADGVIAVGIKFDDGTVYPEKGRLLFADPAVNESTGQITLRAAVPNDQNILMPGLYVRVLMDQVAVDNAFVVPQQAVTRGAKDTVMIVNAQGGMEPREVTVAQQQGTNWIVTSGLKDGDKVVVEGISIAGITGAKKVTPKEWASSENQAAAPQSGVQTASEAKPASEAK", "dna_sequence_from_broadstreet": "ATGGCTTTTTATGCTTTTAAGGCGATGCGTGCGGCCGCGTTGGCTGCCGCCGTTGCATTGGTACTGTCGTCTTGCGGTAAAGGCGGAGACGCGGCGCAGGGCGGGCAGCCTGCTGGTCGGGAAGCCCCTGCGCCCGTCGTCGGTGTCGTAACCGTCCATCCGCAAACCGTCGCATTGACCGTCGAGTTGCCGGGGCGTTTGGAATCGCTGCGTACCGCCGATGTCCGCGCCCAAGTCGGCGGCATCATCCAAAAACGCCTGTTCCAAGAAGGCAGTTATGTCCGTGCCGGACAGCCGCTGTATCAGATCGACAGTTCCACTTATGAAGCAGGTCTGGAAAGCGCGCGCGCGCAACTGGCAACGGCTCAGGCAACGCTTGCCAAAGCGGATGCGGATTTGGCGCGATACAAGCCTTTGGTTGCCGCCGAAGCCGTCAGCCGGCAGGAATACGATGCTGCGGTAACGGCGAAACGTTCTGCCGAGGCAGGCGTTAAAGCGGCGCAGGCGGCAATCAAATCCGCCGGCATCAGCCTGAACCGTTCGCGCATTACCGCGCCGATTTCCGGCTTTATCGGTCAGTCCAAAGTTTCCGAAGGTACGTTGCTGAACGCTGGCGATGCGACCGTACTGGCGACCATCCGCCAAACCAATCCGATGTATGTGAACGTTACCCAGTCTGCATCCGAAGTGATGAAATTGCGCCGTCAGATAGCCGAAGGCAAACTGCTGGCGGCGGATGGTGTGATTGCGGTCGGCATCAAATTTGACGACGGCACAGTTTACCCTGAAAAAGGCCGCCTGCTGTTTGCCGATCCGGCCGTCAACGAATCGACCGGTCAGATTACCCTGCGCGCCGCCGTACCGAACGATCAGAATATCTTGATGCCCGGTCTGTATGTGCGCGTGCTGATGGACCAAGTGGCGGTGGATAACGCATTTGTTGTGCCGCAGCAGGCGGTAACGCGCGGTGCGAAAGATACCGTGATGATTGTGAATGCCCAAGGCGGTATGGAACCCCGCGAGGTAACGGTTGCGCAACAGCAGGGTACGAATTGGATTGTTACGTCGGGTCTGAAGGACGGGGACAAGGTGGTTGTGGAAGGCATCAGTATCGCCGGTATAACGGGTGCGAAAAAGGTAACGCCCAAAGAATGGGCGTCGTCTGAAAACCAAGCCGCCGCGCCTCAATCCGGCGTTCAGACGGCATCTGAAGCCAAACCTGCTTCTGAAGCGAAATAA", "partial": "0", "query_start": 86267, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 42.9}, "gnl|BL_ORD_ID|2484|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "AxyX", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2797", "ARO_accession": "3004143", "ARO_name": "AxyX", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.17872e-89, "max_identities": 151, "bit_score": 272.322, "cvterm_id": "41271", "query": "PLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQ-ENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "P   +   S  + ++ C  + A + A+   EVG++  ++ P  + +ELPGR   YR AEVR +V+GI+ +R + EG ++  G  L+QIDPA  QA+YDS    LA+AQA  +     ++RY  L+  + IS++D+  +VA  +Q+ A V  AKA +++AR+ L Y +VTSPI GR  ++ VTEGALV  GQ T L  VQQLDPIYV+ +Q + + ++L++++  G L+     K +V L+  DG +Y Q GTL F+D+ VD  T ++T+RA+F NP   LLPGM+VR RLE+ +N D  LVP+  + R   G A V+V G+  ++    VTA + +G  W+VT+GL  G+RV+V    ++ PG ++K  E", "sequence_from_db": "PFRTLAFASVLVLVSACSKQEAPEAAKAPAEVGVIVARATPTAVASELPGRLEPYREAEVRARVAGIVTRRLYEEGQEVTRGTPLFQIDPAPLQAAYDSEAAALARAQANLSAAADKLRRYADLVSDRAISERDHAESVAQERQARAEVALAKANLQSARLRLEYARVTSPIDGRARRALVTEGALVGEGQATPLTVVQQLDPIYVNFSQPAAEVMQLQKQIRAGALQGVAPDKMRVRLLLPDGSEYGQGGTLSFADLAVDPGTDNVTMRALFANPGRELLPGMYVRVRLEQAVNRDTFLVPRNALLRNADG-AHVLVAGDDGELRSVAVTAHRLLGPNWVVTEGLAGGERVVVENAAQLAPGQKIKPVE", "sequence_from_broadstreet": "MTHRVPFRTLAFASVLVLVSACSKQEAPEAAKAPAEVGVIVARATPTAVASELPGRLEPYREAEVRARVAGIVTRRLYEEGQEVTRGTPLFQIDPAPLQAAYDSEAAALARAQANLSAAADKLRRYADLVSDRAISERDHAESVAQERQARAEVALAKANLQSARLRLEYARVTSPIDGRARRALVTEGALVGEGQATPLTVVQQLDPIYVNFSQPAAEVMQLQKQIRAGALQGVAPDKMRVRLLLPDGSEYGQGGTLSFADLAVDPGTDNVTMRALFANPGRELLPGMYVRVRLEQAVNRDTFLVPRNALLRNADGAHVLVAGDDGELRSVAVTAHRLLGPNWVVTEGLAGGERVVVENAAQLAPGQKIKPVERTAPSAPVATAGNNEKR", "dna_sequence_from_broadstreet": "ATGACGCACCGAGTTCCCTTCAGAACGCTCGCATTCGCATCCGTACTGGTTCTCGTTTCCGCATGCTCGAAGCAGGAAGCCCCCGAAGCCGCCAAGGCCCCCGCCGAAGTCGGCGTCATCGTGGCCAGGGCCACGCCCACCGCCGTCGCCAGCGAGCTGCCCGGCCGGCTGGAGCCCTATCGCGAGGCCGAGGTCCGCGCCCGCGTGGCCGGCATCGTCACCCGCCGCCTGTATGAAGAAGGCCAGGAAGTGACGCGCGGCACGCCGCTGTTCCAGATCGATCCGGCGCCGCTGCAGGCGGCCTACGATTCCGAGGCGGCCGCGTTGGCGCGTGCCCAGGCCAACCTGTCGGCCGCCGCCGACAAGCTGCGCCGCTACGCCGACCTGGTGTCGGACCGCGCCATCAGCGAACGCGACCACGCCGAGAGCGTGGCCCAGGAACGCCAGGCCCGCGCCGAAGTGGCGTTGGCCAAGGCCAACCTGCAGAGCGCCAGGCTGCGGCTGGAATACGCCCGCGTCACCTCGCCGATCGACGGCCGCGCGCGCCGCGCGCTGGTCACCGAGGGCGCGCTGGTGGGCGAAGGCCAGGCCACGCCGCTGACGGTGGTGCAGCAACTCGACCCGATCTACGTCAACTTCTCGCAACCCGCGGCCGAGGTCATGCAGTTGCAGAAGCAGATCCGCGCCGGCGCCCTGCAAGGCGTCGCGCCCGACAAGATGCGGGTGCGCCTGCTGCTGCCGGACGGCTCCGAGTATGGCCAGGGCGGCACGCTGTCGTTCGCCGACCTGGCGGTCGACCCCGGCACCGACAACGTGACCATGCGCGCGCTGTTCGCCAACCCGGGCCGCGAACTGTTGCCGGGCATGTACGTGCGGGTGCGGCTGGAGCAGGCGGTCAACCGCGACACCTTCCTGGTGCCGCGCAACGCCCTGCTGCGCAACGCCGACGGCGCGCACGTGCTGGTGGCCGGCGACGACGGCGAGCTGCGCAGCGTGGCGGTGACCGCGCACCGGCTGCTGGGCCCGAACTGGGTCGTCACCGAGGGCCTGGCGGGCGGCGAACGCGTGGTGGTGGAAAACGCCGCGCAGCTGGCCCCCGGCCAGAAAATCAAACCGGTCGAGCGGACCGCGCCGAGCGCGCCCGTGGCGACCGCGGGAAATAACGAAAAAAGGTAA", "partial": "0", "query_start": 86180, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 40.81}, "gnl|BL_ORD_ID|1237|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1313", "ARO_accession": "3000774", "ARO_name": "adeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.11574e-83, "max_identities": 139, "bit_score": 255.758, "cvterm_id": "35507", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPG", "match": "L + L LS  L L GCD K   Q      +V +++++   +  +  LP R  A+R AE+RPQV GII K  F +GS+++AG +LY+I+  T++A  +S +  L KA+A     ++ ++RY++LL +  IS+Q+   A A  +Q+ A V   KA +    +NL Y  V +PISGRIG+S VTEGALV  G T  +AT+QQ+D +YVDV QS +++ RL+  L  G L   N    V +  + G  Y  +  + F D+ VD  TG +T R    N +  LLPGM+VR  ++    P ALLVP Q + R   G+  V V+      E+R +   Q     ++   GLK GDRV+V G+++IKP ", "sequence_from_db": "LLLPLFLSIGLILQGCDSKEVAQAEPPPAKVSVLSIQPQSVNFSENLPARVHAFRTAEIRPQVGGIIEKVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLKVQLERYEQLLPSNAISKQEVSNAQAQYRQALADVAQMKALLARQNLNLQYATVRAPISGRIGQSFVTEGALVGQGDTNTMATIQQIDKVYVDVKQSVSEYERLQAALQSGELS-ANSDKTVRITNSHGQPYNVTAKMLFEDINVDPETGDVTFRIEVNNTERKLLPGMYVRVNIDRASIPQALLVPAQAIQRNISGEPQVYVINAQGTAEIRPIEIGQQYEQFYIANKGLKVGDRVVVEGIERIKPN", "sequence_from_broadstreet": "MQKHLLLPLFLSIGLILQGCDSKEVAQAEPPPAKVSVLSIQPQSVNFSENLPARVHAFRTAEIRPQVGGIIEKVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLKVQLERYEQLLPSNAISKQEVSNAQAQYRQALADVAQMKALLARQNLNLQYATVRAPISGRIGQSFVTEGALVGQGDTNTMATIQQIDKVYVDVKQSVSEYERLQAALQSGELSANSDKTVRITNSHGQPYNVTAKMLFEDINVDPETGDVTFRIEVNNTERKLLPGMYVRVNIDRASIPQALLVPAQAIQRNISGEPQVYVINAQGTAEIRPIEIGQQYEQFYIANKGLKVGDRVVVEGIERIKPNQKLALAAWKAPAVANHASSVETKTSIAEGAQP", "dna_sequence_from_broadstreet": "ATGCAAAAGCATCTTTTACTTCCTTTATTTTTATCTATTGGGCTGATATTACAGGGGTGTGATTCAAAAGAAGTCGCTCAAGCTGAGCCACCACCGGCTAAAGTCAGTGTATTAAGCATTCAACCGCAATCGGTAAATTTTAGTGAAAATCTTCCTGCACGTGTACATGCATTCCGTACGGCGGAAATCCGTCCGCAAGTCGGAGGTATCATTGAAAAGGTTCTATTTAAACAAGGTAGTGAAGTTAGAGCAGGGCAAGCCTTATATAAAATTAATTCCGAGACTTTTGAGGCCGATGTAAATAGCAATAGAGCTTCTCTCAATAAAGCTGAAGCTGAGGTGGCAAGACTCAAAGTTCAGTTAGAACGTTATGAGCAGTTATTACCAAGTAATGCAATTAGTAAGCAAGAAGTAAGTAATGCTCAAGCTCAGTATCGTCAGGCTCTAGCCGATGTCGCTCAAATGAAAGCATTGCTGGCCAGACAAAACTTGAATCTGCAATATGCAACAGTTCGAGCGCCTATTTCTGGGCGTATTGGGCAATCTTTTGTCACTGAAGGTGCATTGGTCGGTCAGGGCGATACCAATACGATGGCAACCATTCAACAGATTGATAAAGTCTATGTTGATGTAAAGCAATCGGTTAGTGAGTATGAACGCCTACAGGCTGCGCTACAAAGCGGCGAATTATCAGCAAATAGTGACAAAACCGTTCGTATTACCAATAGCCACGGACAGCCCTATAACGTCACAGCAAAAATGTTGTTTGAAGATATTAATGTTGACCCGGAAACAGGCGATGTCACATTCCGTATTGAAGTTAATAACACTGAACGAAAATTACTTCCGGGCATGTATGTGCGTGTCAATATTGATCGTGCTTCTATTCCTCAAGCGCTATTGGTTCCGGCGCAAGCGATCCAACGTAATATCAGTGGCGAGCCTCAGGTATATGTCATTAACGCCCAAGGGACAGCGGAAATTCGTCCTATCGAAATTGGACAGCAATATGAGCAGTTCTATATCGCTAACAAAGGCTTGAAAGTCGGTGACAGAGTCGTTGTTGAAGGTATTGAACGTATTAAGCCAAATCAAAAATTGGCATTGGCAGCATGGAAAGCACCAGCCGTCGCGAATCATGCTTCAAGTGTAGAAACCAAAACTTCTATAGCTGAAGGGGCACAACCATGA", "partial": "0", "query_start": 86183, "query_end": 87265, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 38.5}, "gnl|BL_ORD_ID|1450|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "amrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "1542", "ARO_accession": "3002982", "ARO_name": "amrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.56101e-77, "max_identities": 146, "bit_score": 241.506, "cvterm_id": "41211", "query": "GCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAA--ANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGR---LKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "GC    ++  A    E  +VT+K   + ++ ELPGR  AYR AEVR +V+GI+  R + EG +++ G  L++IDPA ++A+ D+A G L KA+AA  A +D+   +RY +L+  + +S++D+  A+A  +Q+ AAV +A+A +  A++ L Y  VT+PI GR  ++ VTEGALV   Q T L TV+QLDPIYV+ +Q + D   L++ +  GR   + Q++   +V LV  DG  Y + G L F+D+ VD +T ++ +RA+FPNP+  LLPG +VR  L+  +  DA+LVP+  + RT    A+V VVG+  K+    V A+Q  G  W+VT GL  G+RV+V    + + G  VKA E", "sequence_from_db": "GCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKARAAHLAALDKR--RRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQQD--VEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTA-DSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALE", "sequence_from_broadstreet": "MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKARAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQQDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST", "dna_sequence_from_broadstreet": "ATGAAATACGAATGGGCACGCACGCGCCGCTTGTCGGCGGCGCTCGCGGTCGCGGCGTTCGTCGCGGCCGGCTGCGGCAAGCACGAAAGCGAGCACGACGCCGCCGCGCCGCGCGAGGCGAGCGTCGTCACGGTGAAGAAGACATCGGTGCCGCTGTCGGTCGAATTGCCGGGCCGGCTCGACGCGTACCGGCAGGCCGAGGTGCGCGCGCGGGTCGCGGGCATCGTGACCGCGCGCACCTACGAGGAAGGGCAGGAAGTCAAGCGCGGCGCGGTGCTGTTCAGGATCGATCCCGCGCCGTTCAAGGCGGCGCGCGACGCGGCCGCGGGCGCGCTCGAGAAGGCGCGGGCCGCGCACCTCGCGGCGCTCGACAAGCGCCGCCGCTATGACGAGCTCGTGCGCGACCGCGCGGTCAGCGAGCGCGACCACACCGAGGCGCTCGCCGACGAACGGCAGGCGAAGGCGGCCGTCGCGTCGGCGCGCGCGGAGCTCGCGCGCGCGCAACTGCAGCTCGATTACGCGACCGTCACCGCGCCGATCGACGGCCGCGCGCGCCGCGCGCTCGTGACCGAAGGCGCGCTCGTCGGCCAGGATCAGGCGACGCCGCTCACGACCGTCGAGCAGCTCGATCCGATCTACGTGAACTTCTCGCAGCCCGCGGCCGACGTCGAATCGCTGCGGCGCGCGGTGAAGAGCGGACGCGCGGCGGGCATCGCGCAGCAGGACGTCGAGGTGACGCTCGTGCGCCCGGACGGCAGCACGTACGCGCGCAAGGGCAAGCTGCTGTTCGCGGATCTTGCCGTCGACCCGTCCACCGACACGGTGGCGATGCGTGCGCTCTTTCCGAACCCGGAGCGCGAACTGCTGCCCGGCGCGTACGTGCGGATCGCGCTCGATCGCGCGGTCGCGCGCGACGCGATCCTCGTGCCGCGCGACGCGCTGCTGCGCACGGCCGACAGCGCGACCGTCAAGGTCGTCGGCCAGAACGGCAAGATACGCGACGTGACGGTCGAGGCCGCGCAGATGAAAGGCCGCGACTGGATCGTCACGCGCGGGCTCGCGGGCGGCGAGCGCGTCGTCGTCGTCGACGCCGCGCAATTCGAAGCAGGCACGACGGTGAAGGCGCTCGAGCGCGGCGCCGCCGCGCAGCCGGCCTCCGGCGCCGCCGCGGCTTCCGCGCCCGGCCGGCGCTCAACCTGA", "partial": "0", "query_start": 86225, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 40.67}, "gnl|BL_ORD_ID|313|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexX", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "730", "model_id": "334", "ARO_accession": "3003034", "ARO_name": "mexX", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.22745e-69, "max_identities": 144, "bit_score": 220.32, "cvterm_id": "36804", "query": "GCDDKP-AQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDL-AKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAK-VELVTNDGL--KYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPS", "match": "GC++   A + A+   EVG++  + AP+ IT+ELPGR  AYR AEVR +V+GI+ +R + EG D++AG  L+QIDPA  +A+ D ++G L  + Q  A  D+L  K Y  L+  + IS+++Y  A   A+Q+ A + +AKA +E AR+ L Y  VT+PI GR  ++ VTEGALV     T L  V+Q+DPIYV+ +Q +    + +    D R   E  + +        G   + P +G L F D+ VD  T +I +RA+F NP   LLPG +V+ RL+  +NP A+ VP   + RT +  A V VV     VE  +V A    G  W+++ GLK G+ VIV    +   G  V+A       +Q A+ +APS", "sequence_from_db": "GCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLFQIDPAPLKAALDISRGALPGRGQPRAAADKL--KAYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRARRALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAA---KSRHAAGDPRRPGEGCRRQGHRRAPGPGRRQRVPLAGELLFIDLAVDPGTDTIAMRALFRNPHRELLPGGYVQVRLQRAVNPQAITVP-DALIRTAQ-SAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQHAAGSSVQAVV-----RQPASADAPS", "sequence_from_broadstreet": "MDRLAARLLAALVALFLLGCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLFQIDPAPLKAALDISRGALPGRGQPRAAADKLKAYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRARRALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAAKSRHAAGDPRRPGEGCRRQGHRRAPGPGRRQRVPLAGELLFIDLAVDPGTDTIAMRALFRNPHRELLPGGYVQVRLQRAVNPQAITVPDALIRTAQSAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQHAAGSSVQAVVRQPASADAPSPLAASPAGQ", "dna_sequence_from_broadstreet": "ATGGACCGGCTCGCTGCGCGGCTGCTGGCGGCCCTGGTCGCCCTATTCCTGCTGGGCTGCGAAGAAGCAGCGGACGCCGGGAAGACTGCGGAGGCCCCCGCCGAGGTCGGCGTGATCGTCGCCAGGCCGGCGCCTATCGGCATCACCAGCGAGCTGCCCGGACGCCTGGAAGCGTACCGCCAGGCTGAAGTGCGGGCGCGCGTCGCCGGCATCGTCACCCGTCGCCTGTACGAGGAAGGCCAGGACGTCCGCGCCGGCACCGTGCTGTTCCAGATCGACCCTGCGCCCTTGAAGGCGGCCCTGGACATCAGCCGCGGCGCCCTGCCCGGCCGAGGCCAGCCACGCGCGGCGGCCGACAAGCTCAAGGCGTACGCCGACCTGATCAAGGACCGCGCCATCAGCGAACGCGAGTACACCGAAGCGCAGACCGACGCGCGCCAGGCCCTGGCGCAGATCGCCTCGGCCAAGGCCGAACTGGAGCAGGCCCGCCTGCGCCTGGGCTACGCCACGGTCACCGCGCCGATCGACGGCCGCGCGCGGCGTGCGCTGGTCACCGAAGGCGCGCTGGTCGGCGAGGACTCGCCGACACCGCTGACCCGCGTCGAGCAGATCGATCCGATCTACGTGAACTTCTCCCAGCCGGCCGCGAAGTCGCGCCATGCAGCGGGCGATCCGCGAAGGCCAGGTGAAGGGTGTCGCCGACAAGGACATCGCCGTGCGCCTGGTCCTGGCCGACGGCAGCGAGTACCGCTGGCCGGCGAGCTGCTGTTCATCGACCTGGCGGTCGACCCCGGCACCGACACCATCGCCATGCGTGCCCTGTTCCGCAATCCGCATCGCGAATTGCTGCCCGGCGGCTACGTGCAGGTGCGCCTGCAGCGCGCGGTGAACCCGCAGGCGATCACCGTCCCGGACGCGCTGATCCGTACCGCCCAGTCCGCCGTGGTCAAGGTGGTCAACCCAAAGGGCTTGGTGGAAGACGTGGAGGTCCGCGCCGACACCCTGCAGGGCCGCGACTGGATCATCAGCCGCGGGCTCAAGGGCGGCGAGTGGGTGATCGTCGAGAACGCCGCCCAGCATGCCGCCGGCTCCAGCGTCCAGGCGGTGGTCCGCCAGCCGGCCAGCGCCGACGCCCCCTCACCGCTGGCCGCCTCGCCGGCGGGCCAGTGA", "partial": "0", "query_start": 86225, "query_end": 87331, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 38.5}, "gnl|BL_ORD_ID|1153|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeG", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "1226", "ARO_accession": "3000778", "ARO_name": "adeG", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.13297e-48, "max_identities": 112, "bit_score": 166.392, "cvterm_id": "35535", "query": "ELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQ----TTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEG-INPDALLVPQQ-GVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSE", "match": "E  GR  A    ++RPQVSG ++  +F +GS ++ G  L+ IDP  ++A  + AK  LA A+A        + R Q+L+ +  +S+Q+ D A   A+ +NA + AA+AAV++AR+NL YT++T+P+SGRI ++ VT G +V  G      T+L +V +L   Y         +L+          ++ + +  V +   +   + + GT+   D  ++ T+G+I +RA F NP+  LLPG++ R RL  G   P  L+ P   GV +  R    V+VV   ++   R+V          +V  GL++GDR++V GLQ+I+PG  V    V   + Q  A   P +", "sequence_from_db": "EYSGRLEAIDQVDIRPQVSGKLIAVHFKDGSLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYTRITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRL---YASFDVDEQTYLKYISN------QRNSAQVPVYMGLANETGFTREGTINSIDNNLNTTSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKR---FVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIVVNGLQRIRPGDPVTPHLVPMPNSQITASATPPQ", "sequence_from_broadstreet": "MSFSRKQFALSAIFVAILATGGSFMLLHENADAKAAPTAAQQAATVDVAPVVSKTITDWQEYSGRLEAIDQVDIRPQVSGKLIAVHFKDGSLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYTRITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRLYASFDVDEQTYLKYISNQRNSAQVPVYMGLANETGFTREGTINSIDNNLNTTSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKRFVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIVVNGLQRIRPGDPVTPHLVPMPNSQITASATPPQPQPTDKTSTPAKG", "dna_sequence_from_broadstreet": "ATGTCATTTTCCCGCAAACAGTTTGCACTGTCTGCCATCTTTGTCGCTATTTTAGCAACCGGTGGCAGTTTTATGTTGTTACATGAAAATGCCGATGCAAAAGCTGCACCAACCGCTGCCCAACAAGCTGCTACTGTTGATGTAGCCCCAGTAGTAAGCAAAACCATTACCGATTGGCAAGAATATTCCGGTCGTTTAGAAGCAATTGATCAAGTTGATATTCGGCCTCAAGTTTCAGGAAAACTTATTGCCGTACATTTCAAAGATGGAAGCCTCGTTAAAAAAGGTGATTTACTTTTCACAATCGACCCTCGTCCTTTTGAAGCAGAACTGAACCGTGCAAAAGCCCAACTTGCTTCAGCTGAAGCACAGGTAACATATACCGCAAGCAATCTTTCGCGTATTCAACGTCTCATTCAGAGTAATGCTGTTTCTCGCCAAGAACTGGATTTAGCCGAAAATGATGCACGTTCAGCGAATGCTAACCTACAAGCCGCTAGAGCTGCTGTCCAATCTGCACGTTTAAATCTAGAATACACCCGTATTACAGCACCTGTCAGCGGCCGGATTTCACGAGCTGAAGTCACCGTTGGTAATGTAGTTTCTGCAGGTAACGGCGCACAGGTTTTAACAAGTTTAGTGTCTGTATCCCGCCTTTATGCATCTTTCGATGTTGATGAACAAACTTACCTGAAATATATCAGTAATCAGCGTAATTCAGCACAAGTACCTGTCTATATGGGACTTGCCAATGAAACAGGCTTTACTCGTGAAGGTACAATCAACTCAATCGATAACAATCTGAATACAACCTCAGGTACGATCCGTGTTCGCGCAACTTTTGACAATCCAAACGGTGTTTTATTACCAGGCCTATATGCACGAATTCGTTTAGGTGGAGGCCAACCTCGCCCAGCGATTCTGATTAGTCCAACCGCGGTTGGTGTCGACCAAGATAAACGTTTTGTCGTAGTAGTAGATGCGAAAAATCAAACTGCTTATCGCGAAGTAAAACTCGGTGCCCAACAAGATGGCTTGCAAATCGTAAATAGCGGATTACAAGCGGGTGATCGTATTGTAGTGAATGGTTTACAACGGATTCGTCCGGGTGACCCTGTTACACCGCATCTCGTCCCTATGCCAAATTCACAAATCACTGCTAGCGCTACTCCTCCTCAACCTCAGCCAACAGATAAAACATCAACTCCGGCAAAAGGTTAA", "partial": "0", "query_start": 86318, "query_end": 87334, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.46}, "gnl|BL_ORD_ID|1112|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "cmeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "710", "model_id": "1181", "ARO_accession": "3000783", "ARO_name": "cmeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "36989": {"category_aro_accession": "3000645", "category_aro_cvterm_id": "36989", "category_aro_name": "cefotaxime", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "37139": {"category_aro_accession": "3000759", "category_aro_cvterm_id": "37139", "category_aro_name": "fusidic acid", "category_aro_description": "Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to  block protein synthesis.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.13079e-47, "max_identities": 115, "bit_score": 162.54, "cvterm_id": "37595", "query": "VLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTL--KSAPLQITTELPGR-TSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "+L+L     LT C  + A +    MP   + T+  KS  L +    P +  S Y +  ++PQVSG+I+ + F  G  ++ G +L+ I+ A ++AS DSA G    A+A          R + L     ISQ++YD+++AT   + A++ +A+A +  ARI+L +T++ +P  G IG + V  G  V    TT L  V  L+PIY D   S  D L L +    G+   ++  A + L   +G      G L F D  +D  +G++  +A+F N + TLLPG F     E  I  +   VPQ  + +  + D  V++V  G KVE   V  S    +  ++  GL++GD++I+   +KI+ G +VK", "sequence_from_db": "ILVLGVVFLLTACSKEEAPK--IQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVI-IKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTS-TTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLNL---NG--ETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAI-KQDQNDVYVLLVKNG-KVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVK", "sequence_from_broadstreet": "MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLNLNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVKEIGAQ", "dna_sequence_from_broadstreet": "ATGAAATTATTTCAAAAAAATACTATTTTAGTTTTAGGTGTTGTGTTTTTACTCACTGCTTGCAGCAAAGAAGAAGCGCCAAAAATACAAATGCCGCCTCAACCTGTAACAACCATGAGTGCTAAATCTGAAGATTTACCACTTAATTTTACCTATCCTGCCAAACTTGTCAGTGATTATGATGTTATTATAAAACCTCAAGTTAGCGGTGTGATAGTAAATAAACTTTTTAAGGCTGGAGATAAGGTAAAAAGAGGACAAACATTATTTATTATAGAACAAGCCAAATTTAAAGCTAGCGTTGATTCAGCCTACGGACAAGCGTTAATGGCTAAAGCAACTTTCGAAAATGCAAGTAAAGATTTTAATCGCTCTGAGGCTCTTTTTAGCAAAAACGCAATCTCTCAAAAAGAATACGACTCTTCTCTTGCTACATTTAATAATGCAAAAGCTAGTCTAGCAAGTGCTAGAGCACAGCTTGCAAATGCAAGAATTGATCTAGATCATACCGAAATAAAAGCTCCTTTTGATGGTACTATAGGAGATGCTTTAGTTAATATAGGAGATTATGTAAGCACTTCAACAACTGAACTAGTTAGAGTTACAAATTTAAATCCTATTTACGCAGATTTCTTTATTTCAGATACAGATAAACTAAATTTAGTCCGCAATACTCAAAGTGGAAAATGGGATTTAGACAGCATTCATGCAAATTTAAATCTTAACGGAGAAACTGTTCAAGGCAAACTTTATTTTATTGATTCTGTTATAGATGCCAATAGTGGAACAGTAAAAGCCAAAGCTGTATTTGATAACAACAACTCGACACTTTTACCAGGTGCTTTTGCAACGATTACCTCAGAAGGTTTTATACAAAAAAATGGCTTTAAGGTACCTCAAATAGCTATTAAACAAGATCAAAATGATGTTTATGTTCTTCTTGTTAAAAATGGAAAAGTAGAAAAATCTTCTGTACATATAAGCTACCAAAACAATGAATACGCTATTATTGACAAAGGATTGCAAAATGGCGATAAAATCATTTTGGATAATTTTAAAAAAATTCAAGTTGGTAGCGAAGTTAAAGAAATTGGAGCACAATAA", "partial": "0", "query_start": 86192, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 31.51}, "gnl|BL_ORD_ID|2355|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MuxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "2717", "ARO_accession": "3004073", "ARO_name": "MuxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "37626": {"category_aro_accession": "3001227", "category_aro_cvterm_id": "37626", "category_aro_name": "kitasamycin", "category_aro_description": "Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens.", "category_aro_class_name": "Antibiotic"}, "40353": {"category_aro_accession": "3003701", "category_aro_cvterm_id": "40353", "category_aro_name": "rokitamycin", "category_aro_description": "Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.81611e-47, "max_identities": 111, "bit_score": 162.54, "cvterm_id": "36804", "query": "VGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGL--KYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVA", "match": "VG+  ++   L +     G  +A+    V+P+V+G ++K  F EG +++AG  L  +DP TY+A+   A+G L + QA     ++ ++RY+ L     I++Q  DT  A  +Q    +   +  V+ AR+NL +T+V +PISGR+G   V  G LV +G TT L  + Q+ PI V           L Q+     ++Q NG  K+ +   D    K    GTL   D  +D TTG++ L+A F N D  L P  FV  RL        L +P   V R   G   V VVG  +KV  R V    +  ++ +V  GLK+G++V+V G  +++ G++V+  E +", "sequence_from_db": "VGVARVEQGDLALHFNALGTVTAFNTVNVKPRVNGELVKVLFQEGQEVKAGDLLAVVDPRTYKAALAQAEGTLMQNQAQLKNAEIDLQRYKGLYAEDSIAKQTLDTQEAQVRQLQGTIRTNQGQVDDARLNLTFTEVRAPISGRLGLRQVDIGNLVTSGDTTPLVVITQVKPISV--------VFSLPQQQIGTVVEQMNGPGKLTVTALDRNQDKVLAEGTLTTLDNQIDTTTGTVKLKARFENADGKLFPNQFVNVRLLAQTLKGVLTIPANAVQRGTNG-IYVYVVGADNKVSQRSVAIGTSENERVVVESGLKAGEQVVVEGTDRLRDGMEVRVAEAS", "sequence_from_broadstreet": "MTPTTGKSKFRTLRPWLITALAFAAVIGLVMWLAAPASAPSSDGRPGRGGKPGAALPKANALTVGVARVEQGDLALHFNALGTVTAFNTVNVKPRVNGELVKVLFQEGQEVKAGDLLAVVDPRTYKAALAQAEGTLMQNQAQLKNAEIDLQRYKGLYAEDSIAKQTLDTQEAQVRQLQGTIRTNQGQVDDARLNLTFTEVRAPISGRLGLRQVDIGNLVTSGDTTPLVVITQVKPISVVFSLPQQQIGTVVEQMNGPGKLTVTALDRNQDKVLAEGTLTTLDNQIDTTTGTVKLKARFENADGKLFPNQFVNVRLLAQTLKGVLTIPANAVQRGTNGIYVYVVGADNKVSQRSVAIGTSENERVVVESGLKAGEQVVVEGTDRLRDGMEVRVAEASPQVLEGEPQKPQTGRPSGLQGDSVGSGSAE", "dna_sequence_from_broadstreet": "ATGACTCCAACGACCGGTAAATCCAAGTTCCGTACCCTGCGCCCGTGGCTGATCACCGCCCTGGCCTTCGCCGCCGTGATCGGCCTGGTGATGTGGCTGGCGGCGCCCGCCTCGGCACCGTCCTCCGACGGGCGACCCGGTCGCGGCGGCAAGCCGGGCGCCGCGCTGCCCAAGGCCAACGCGCTCACCGTCGGCGTGGCCAGGGTGGAGCAGGGCGACCTGGCGCTGCATTTCAACGCGCTTGGCACCGTCACCGCCTTCAACACGGTGAACGTCAAGCCGCGGGTCAACGGCGAGCTGGTCAAGGTGCTGTTCCAGGAGGGGCAGGAGGTCAAGGCCGGCGACCTGCTGGCGGTGGTCGACCCGCGCACCTACAAGGCGGCGCTGGCCCAGGCCGAGGGCACGCTGATGCAGAACCAGGCGCAACTGAAGAACGCCGAGATCGACCTGCAGCGCTACAAGGGGCTGTATGCCGAGGACTCGATAGCCAAGCAGACCCTGGATACCCAGGAAGCCCAGGTCCGCCAGTTGCAGGGCACCATCCGTACCAACCAGGGCCAGGTCGACGACGCCCGCCTCAACCTGACCTTCACCGAGGTCCGCGCACCGATTTCCGGGCGCCTCGGCCTGCGCCAGGTGGACATCGGCAACCTGGTCACCAGCGGCGATACCACGCCGCTGGTGGTGATCACCCAGGTCAAGCCGATCTCGGTGGTGTTCAGCCTGCCGCAGCAGCAGATCGGCACCGTCGTCGAGCAGATGAACGGCCCCGGCAAGCTGACGGTCACCGCGCTGGACCGCAACCAGGACAAGGTTCTCGCCGAAGGCACCCTGACCACCCTGGACAACCAGATCGACACCACCACCGGCACGGTCAAGCTCAAGGCGCGCTTCGAGAACGCCGACGGCAAGCTGTTCCCCAACCAGTTCGTCAACGTGCGCCTGCTGGCGCAGACCCTCAAAGGCGTGCTGACCATTCCGGCCAACGCCGTGCAGCGCGGCACCAACGGTATCTATGTCTACGTGGTCGGCGCCGACAACAAGGTCAGCCAGCGCAGCGTCGCCATCGGCACCAGCGAGAACGAGCGGGTGGTGGTGGAAAGCGGCCTGAAGGCCGGCGAGCAGGTGGTGGTGGAAGGCACCGACCGCCTGCGCGACGGTATGGAAGTGCGTGTCGCCGAGGCCTCCCCGCAGGTCCTCGAGGGCGAGCCGCAGAAACCGCAGACTGGCCGCCCCAGCGGCCTCCAGGGCGACTCGGTGGGTAGCGGGAGCGCTGAATGA", "partial": "0", "query_start": 86273, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.46}, "gnl|BL_ORD_ID|2216|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "oqxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "model_id": "2399", "ARO_accession": "3003922", "ARO_name": "oqxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.9914e-46, "max_identities": 126, "bit_score": 160.614, "cvterm_id": "35914", "query": "NRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATV---QQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKA---KVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKI-KPGVQVKAQEVA", "match": "N  LT L  +++   S  L GCDD  AQ  A   P V    +    +       GR  A    ++RP+VSG I K N+ +G +++ G  L+ ID  TY+A+ + A+  LA+A+  A++ Q    R  KL+ T  +S+++++   + A Q+ A + AA+AAV+ A++NL +TKVT+PI GR  ++ +T G LV  G T ++ T    Q+   +Y DV +S+  +L  +     G+    + +A   ++ LV  +G  YP  G ++F D  +  +TG+I +RA+  N      PG+F R RL       A L+  + V  T +    V +V +  K + R +T  +      +V  GL  GD VIV GLQK+  PG+ V A+ VA", "sequence_from_db": "NIHLTALGAMML---SFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDEST--YLHYQNLARRGQGASSDNQALPVEIGLVGEEG--YPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVL-TDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVA", "sequence_from_broadstreet": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "dna_sequence_from_broadstreet": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCACAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACTGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTCGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAAAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTGGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "partial": "0", "query_start": 86165, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.9}, "gnl|BL_ORD_ID|1064|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1067", "ARO_accession": "3000803", "ARO_name": "MexE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.65455e-45, "max_identities": 125, "bit_score": 157.147, "cvterm_id": "36804", "query": "LMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELAD--GRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQ--EVASDD", "match": "L L+  L L+ C   P        P+V +  +   PL    E  GR  A    E+RP+VSG I +  F EG+ ++ G  L+QIDP  ++A     +  L +A+AA        +R ++L  +  IS +  D     AQ++ AAV A +A ++ AR+NL++T++T+PI GR+ ++ VT G LV +G+T  L T+   D +Y         FL+   ELA   GR  +      + L + DG   P  G L+F D  V+  TG+I  RA+F N      PG++VR +L       A L+  + V  T  G   V+V+   +K   R V     +    +V  GL  GDR++V GLQ+++PG+QV  Q  E+AS D", "sequence_from_db": "LALAAVLVLSACGKAPETTQGMAAPKVSVAEVIEQPLNEWDEFTGRLEAPESVELRPRVSGYIDRVAFHEGALVKKGDLLFQIDPRPFEAEVKRLEAQLQQARAAQARSVNEAQRGERLRASNAISAELADARTTAAQEAKAAVAATQAQLDAARLNLSFTRITAPIDGRVSRAEVTAGNLVNSGETL-LTTLVSTDKVYAYFDADERVFLKY-VELARQAGRDTRSESPVYLGLSSEDG--NPHLGRLDFLDNQVNPRTGTIRGRAVFDNAKGEFTPGLYVRLKLVGSKTYAATLIKDEAVG-TDLGKKFVLVLDGDNKTVYRTVEMGPKLEGLRIVRSGLSKGDRIVVNGLQRVRPGMQVDPQKVEMASAD", "sequence_from_broadstreet": "MEQSSHFSWRYPLALAAVLVLSACGKAPETTQGMAAPKVSVAEVIEQPLNEWDEFTGRLEAPESVELRPRVSGYIDRVAFHEGALVKKGDLLFQIDPRPFEAEVKRLEAQLQQARAAQARSVNEAQRGERLRASNAISAELADARTTAAQEAKAAVAATQAQLDAARLNLSFTRITAPIDGRVSRAEVTAGNLVNSGETLLTTLVSTDKVYAYFDADERVFLKYVELARQAGRDTRSESPVYLGLSSEDGNPHLGRLDFLDNQVNPRTGTIRGRAVFDNAKGEFTPGLYVRLKLVGSKTYAATLIKDEAVGTDLGKKFVLVLDGDNKTVYRTVEMGPKLEGLRIVRSGLSKGDRIVVNGLQRVRPGMQVDPQKVEMASADTLATLARLRQSVGDSEPPKVAASKDNATRNEPRG", "dna_sequence_from_broadstreet": "ATGGAACAGTCATCCCACTTCTCCTGGCGCTACCCCCTCGCACTCGCGGCCGTACTGGTCCTGAGCGCCTGCGGCAAGGCCCCGGAAACCACCCAAGGCATGGCGGCGCCCAAGGTCAGCGTCGCCGAAGTCATCGAACAACCGCTGAACGAGTGGGACGAATTCACCGGCCGCCTGGAGGCCCCGGAGTCGGTGGAGCTGCGCCCGCGGGTGTCGGGCTACATCGACCGCGTGGCCTTCCATGAAGGCGCACTGGTGAAGAAAGGCGACCTGCTGTTCCAGATCGACCCGCGCCCGTTCGAGGCCGAGGTCAAGCGCCTCGAAGCCCAGCTGCAACAGGCCCGCGCGGCCCAGGCGCGGAGCGTCAACGAAGCCCAGCGCGGCGAACGCCTGCGCGCCAGCAACGCGATCTCCGCGGAACTCGCCGACGCCCGCACCACCGCCGCCCAGGAAGCCAAGGCGGCGGTCGCCGCGACCCAGGCGCAACTGGACGCGGCGCGCCTGAACCTGAGCTTCACCCGGATCACCGCGCCGATCGACGGTCGCGTCAGCCGCGCCGAGGTCACCGCCGGCAACCTGGTCAACTCCGGGGAGACCCTGCTCACCACCCTGGTCAGCACCGACAAGGTCTACGCCTACTTCGACGCCGACGAGCGCGTGTTCCTCAAGTACGTCGAGCTGGCCCGCCAGGCCGGTCGCGACACGCGCAGCGAGAGCCCGGTGTACCTCGGCCTGAGCAGCGAGGACGGCAACCCGCACCTGGGCCGGCTGGACTTCCTCGACAACCAGGTCAACCCGCGTACCGGCACCATCCGCGGCCGCGCCGTGTTCGACAACGCCAAGGGCGAGTTCACCCCGGGCCTCTACGTGCGCCTGAAGCTGGTCGGCAGCAAGACCTACGCCGCCACCCTGATCAAGGACGAAGCGGTCGGCACCGACCTGGGCAAGAAGTTCGTGCTGGTCCTGGATGGCGACAACAAGACCGTCTACCGCACCGTCGAGATGGGACCGAAGCTGGAGGGCCTGCGCATCGTCCGCAGCGGCCTGAGCAAGGGCGACCGGATCGTCGTGAATGGCCTGCAGCGGGTCCGCCCGGGCATGCAGGTGGATCCGCAGAAGGTCGAGATGGCCAGCGCCGACACCCTGGCCACCCTCGCGCGCCTGCGGCAGTCGGTCGGCGACAGCGAACCACCGAAGGTGGCGGCGTCCAAGGACAACGCCACTCGCAACGAGCCGCGCGGCTGA", "partial": "0", "query_start": 86195, "query_end": 87301, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 33.51}, "gnl|BL_ORD_ID|2053|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexP", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2211", "ARO_accession": "3003698", "ARO_name": "mexP", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "37626": {"category_aro_accession": "3001227", "category_aro_cvterm_id": "37626", "category_aro_name": "kitasamycin", "category_aro_description": "Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens.", "category_aro_class_name": "Antibiotic"}, "40353": {"category_aro_accession": "3003701", "category_aro_cvterm_id": "40353", "category_aro_name": "rokitamycin", "category_aro_description": "Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.78268e-44, "max_identities": 119, "bit_score": 153.68, "cvterm_id": "36752", "query": "LTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELA--DGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQV", "match": "+ GC +      A   P V +  +   P+    E  G  +A    E+RP+V+G I      EG  ++ G  L+ IDP  ++A+ D+A+  L +A+AAA + +   +R + L   K ++++  D+A+A+   S A V AA+AA++ A+++L +T+VT+PI GR+G   VTEG  V NG  TAL ++  +DP+YV        +L   Q LA   GR  ++  + KV L+T++   Y +S  L+F     D+ TG++ +RA+  NPD  L PG+F + RLE G     +LV    +  T +G   V+VV EG+K + R V     +    +V  GL+ G+R++V GL  ++P +Q+", "sequence_from_db": "IAGCGESAPPGAASAPPSVPVAEVVVRPVTPYAEFTGSLTAVEQVELRPRVAGYIQDVTVPEGRLVEKGQQLFLIDPRVFKAAQDAARARLREAEAAALLARTEHERAELLYARKVVARERLDSAIASRNASKAQVDAARAALDAAQLDLGFTRVTAPIGGRVGHIQVTEGNYVTNG-VTALTSIVSVDPLYVYFDVDERTYL---QALAPTRGREGEQAPRVKVALLTDE--SYGRSSRLDFLANAADRGTGTVRVRAVVDNPDGQLTPGLFAKVRLETGKPRAQVLVADHSIG-TDQGRRYVLVVDEGNKTQYRPVELGPMVDGLRVVRQGLQPGERIVVKGL--VRPDMQI", "sequence_from_broadstreet": "MNLRHFIRITATLGVAALIAGCGESAPPGAASAPPSVPVAEVVVRPVTPYAEFTGSLTAVEQVELRPRVAGYIQDVTVPEGRLVEKGQQLFLIDPRVFKAAQDAARARLREAEAAALLARTEHERAELLYARKVVARERLDSAIASRNASKAQVDAARAALDAAQLDLGFTRVTAPIGGRVGHIQVTEGNYVTNGVTALTSIVSVDPLYVYFDVDERTYLQALAPTRGREGEQAPRVKVALLTDESYGRSSRLDFLANAADRGTGTVRVRAVVDNPDGQLTPGLFAKVRLETGKPRAQVLVADHSIGTDQGRRYVLVVDEGNKTQYRPVELGPMVDGLRVVRQGLQPGERIVVKGLVRPDMQITPRLAEIDGTPVDLSKTVGAAQ", "dna_sequence_from_broadstreet": "ATGAATCTCAGACACTTCATCCGCATCACCGCGACGCTAGGTGTCGCGGCCCTTATCGCTGGCTGCGGGGAATCGGCGCCGCCGGGGGCGGCGAGCGCCCCGCCAAGCGTTCCCGTCGCCGAGGTGGTGGTTCGCCCGGTGACACCCTACGCCGAGTTCACCGGCTCGCTGACCGCTGTCGAGCAGGTAGAACTGCGGCCGCGCGTCGCCGGCTACATCCAGGACGTTACGGTGCCGGAAGGCCGCCTGGTAGAGAAGGGCCAGCAACTGTTCCTCATCGACCCGCGCGTGTTCAAGGCGGCGCAGGATGCCGCCAGGGCACGCCTGCGCGAGGCCGAGGCCGCGGCGTTGCTGGCGCGCACCGAACACGAGCGAGCCGAGCTGCTGTATGCGCGGAAGGTCGTCGCCCGGGAGCGGCTCGACAGCGCCATCGCCTCGCGCAATGCCAGCAAGGCCCAGGTCGATGCGGCCAGGGCCGCCCTCGACGCGGCGCAACTGGATCTCGGCTTCACGCGGGTGACGGCACCGATCGGCGGGCGTGTCGGGCATATCCAGGTCACCGAGGGCAACTACGTCACCAATGGCGTCACCGCGCTGACCAGCATCGTTTCGGTCGATCCGCTGTACGTGTACTTCGATGTCGACGAGCGCACCTACCTGCAGGCCCTGGCGCCGACCCGCGGCAGGGAAGGCGAGCAGGCCCCCAGGGTCAAGGTGGCGCTGCTCACCGACGAGTCCTATGGACGAAGCAGTCGCCTCGATTTCCTCGCCAACGCCGCCGACCGCGGGACCGGCACGGTCCGGGTTCGGGCGGTGGTGGACAACCCGGACGGGCAACTGACGCCGGGGCTGTTCGCCAAGGTCAGGCTGGAGACCGGCAAGCCTCGCGCGCAGGTGCTGGTCGCCGACCATTCCATCGGCACCGACCAGGGCAGGCGCTATGTGCTGGTCGTCGACGAAGGCAACAAGACCCAGTACCGGCCGGTGGAACTCGGCCCGATGGTCGACGGCCTGCGGGTCGTCCGCCAGGGCCTGCAGCCGGGCGAGCGCATCGTCGTCAAGGGCCTGGTCCGGCCGGACATGCAGATCACACCGCGCCTTGCGGAAATCGATGGCACGCCCGTCGACCTGTCGAAGACCGTGGGGGCCGCACAATGA", "partial": "0", "query_start": 86219, "query_end": 87274, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 33.62}, "gnl|BL_ORD_ID|399|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdsA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "770", "model_id": "429", "ARO_accession": "3000789", "ARO_name": "mdsA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.55805e-40, "max_identities": 106, "bit_score": 143.28, "cvterm_id": "35734", "query": "SAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQN---GQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEV", "match": "S  L  T E  G  +A    E+R +V G +   +  EG  +  G  L+QIDP  ++ + D+A   L +A+  A   Q    R Q+L+ +  +S+++ D   AT     A + +AKAAV  AR+ L++T++T+PI+GR+ +  VT G LV     G  T L T+   +P+YV        +L+    L   R  +      + L T++GL Y   G L+F    ++++TG+I  RA+ P+PD  L PG+F R  L  G   + +L+    V+   +G   V++VG+ ++VE R V   Q +    +VT G+  G+++I+ GL  ++PG+ V  + V", "sequence_from_db": "SRTLAPTAEFTGFLAAPETVELRSRVGGTLDAISVPEGRLVSRGQLLFQIDPRPFEVALDTAVAQLRQAEVLARQAQADFDRIQRLVASGAVSRKNADDVTATRNARQAQMQSAKAAVAAARLELSWTRITAPIAGRVDRILVTRGNLVSGGVAGNATLLTTIVSHNPMYVYFDIDEATWLK---ALRHTRSDKNPPVVNMGLTTDNGLPY--QGVLDFMGNQMNRSTGTIRARAVIPDPDGMLSPGLFARISLPIGEPRETVLIDDLAVS-ADQGKNYVLIVGKENQVEYRPVELGQMVDGFRVVTQGVLPGEKIILKGL--VRPGMTVAPRLV", "sequence_from_broadstreet": "MRRTFKIMLIAGVIAAIGGVIYMAGEALWDKDNAVGPPASAPPPPSVPVAKALSRTLAPTAEFTGFLAAPETVELRSRVGGTLDAISVPEGRLVSRGQLLFQIDPRPFEVALDTAVAQLRQAEVLARQAQADFDRIQRLVASGAVSRKNADDVTATRNARQAQMQSAKAAVAAARLELSWTRITAPIAGRVDRILVTRGNLVSGGVAGNATLLTTIVSHNPMYVYFDIDEATWLKALRHTRSDKNPPVVNMGLTTDNGLPYQGVLDFMGNQMNRSTGTIRARAVIPDPDGMLSPGLFARISLPIGEPRETVLIDDLAVSADQGKNYVLIVGKENQVEYRPVELGQMVDGFRVVTQGVLPGEKIILKGLVRPGMTVAPRLVPMRQNVTDKQTATLTKADGDSAPKAVRQ", "dna_sequence_from_broadstreet": "ATGCGTAGAACATTCAAAATTATGTTGATAGCCGGCGTCATCGCCGCCATCGGGGGCGTGATTTACATGGCCGGCGAAGCACTATGGGATAAAGACAACGCCGTCGGCCCCCCGGCCAGCGCGCCGCCTCCACCGTCGGTACCGGTTGCTAAAGCCCTTAGCCGTACACTCGCGCCTACGGCGGAATTCACCGGTTTTCTGGCCGCGCCGGAAACCGTGGAGCTGCGTTCGCGCGTGGGAGGAACCCTTGACGCCATCAGCGTTCCGGAAGGACGTCTGGTAAGCCGCGGACAACTGCTGTTCCAGATCGATCCGCGCCCGTTCGAGGTCGCCCTCGACACCGCCGTCGCGCAATTACGTCAGGCTGAAGTACTGGCCCGCCAGGCGCAGGCGGATTTCGATCGCATTCAACGACTGGTCGCCAGCGGCGCCGTATCACGTAAAAACGCTGACGATGTCACCGCCACGCGTAATGCGCGACAGGCGCAGATGCAATCGGCCAAAGCCGCCGTCGCCGCAGCGCGCCTTGAACTCTCCTGGACCCGTATTACCGCGCCCATTGCCGGACGCGTTGACCGCATACTGGTGACCCGGGGCAATCTGGTCAGCGGCGGCGTAGCGGGTAACGCCACGCTTCTGACGACTATCGTGTCTCACAATCCCATGTATGTGTATTTCGATATTGACGAAGCCACCTGGCTGAAGGCGTTACGGCATACCCGCTCCGACAAAAATCCACCGGTAGTCAACATGGGGTTAACCACCGATAACGGGCTGCCTTATCAGGGCGTACTCGACTTTATGGGCAATCAGATGAACCGCAGCACCGGCACTATCCGGGCACGCGCCGTGATTCCTGACCCCGACGGAATGCTTTCTCCCGGCCTGTTTGCCCGAATCAGTTTGCCCATCGGCGAGCCGCGGGAAACCGTGCTGATTGACGATCTGGCGGTGAGCGCCGATCAGGGCAAAAACTATGTGCTGATCGTCGGCAAGGAGAATCAGGTGGAGTATCGTCCGGTTGAGTTGGGACAAATGGTCGATGGATTCCGCGTCGTTACACAGGGAGTACTGCCGGGAGAAAAAATCATCCTCAAGGGGCTGGTGCGTCCTGGCATGACCGTTGCGCCACGTCTGGTGCCGATGCGGCAGAATGTGACCGACAAACAGACCGCGACATTGACTAAAGCGGACGGCGACAGTGCGCCGAAGGCGGTGCGCCAATGA", "partial": "0", "query_start": 86294, "query_end": 87289, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 31.64}, "gnl|BL_ORD_ID|359|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "387", "ARO_accession": "3000792", "ARO_name": "mdtA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.8515e-37, "max_identities": 106, "bit_score": 135.961, "cvterm_id": "36849", "query": "AQQGAQHMPEVGIVTLKS---APLQITTELP----------GRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAK-VELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVAS", "match": "A + AQ  P  G   ++S   AP+Q  T +           G  +A     VR +V G ++  +F EG  ++AG  L +IDP+ ++ +   A+G LAK +A     +  + RYQ+L  T  +S+Q+ D   A   ++   + A +A+V +A++ L ++++T+P+ GR+G   V  G  + +G TT +  + Q  PI +  T   +D   + Q        Q+ GK   VE       K    GTL   D  +D TTG+I ++A F N D  L P  FV AR+      +A+++P   +     G   V V+   +KV    VT       K ++  G+ +GDRV+  G+ ++  G +V+  E  S", "sequence_from_db": "ATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQ-------AQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGH-FVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQS", "sequence_from_broadstreet": "MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS", "dna_sequence_from_broadstreet": "ATGAAAGGTAGTTATAAATCCCGTTGGGTAATCGTAATCGTGGTGGTTATCGCCGCCATCGCCGCATTCTGGTTCTGGCAAGGCCGCAATGACTCCCGGAGTGCAGCCCCAGGGGCGACGAAACAAGCGCAGCAATCGCCAGCGGGTGGTCGACGTGGTATGCGTTCCGGCCCATTAGCCCCGGTTCAGGCGGCGACCGCCGTAGAACAGGCAGTTCCGCGTTACCTCACCGGGCTTGGCACCATTACCGCCGCTAATACCGTTACGGTGCGCAGCCGCGTGGACGGCCAACTGATAGCGTTACATTTCCAGGAAGGCCAGCAGGTCAAAGCAGGCGATTTACTGGCAGAAATTGACCCCAGCCAGTTCAAAGTTGCATTAGCACAAGCCCAGGGCCAACTGGCAAAAGATAAAGCCACGCTTGCCAACGCCCGCCGTGACCTGGCGCGTTATCAACAACTGGCAAAAACCAATCTCGTTTCCCGCCAGGAGCTGGATGCCCAACAGGCGCTGGTCAGTGAAACCGAAGGCACCATTAAGGCTGATGAAGCAAGCGTTGCCAGCGCGCAGCTGCAACTCGACTGGAGCCGGATTACCGCACCAGTCGATGGTCGCGTTGGTCTCAAGCAGGTTGATGTTGGTAACCAAATCTCCAGTGGTGATACCACCGGGATCGTGGTGATCACCCAGACGCATCCTATCGATTTAGTCTTTACCCTGCCGGAAAGCGATATCGCTACCGTAGTGCAGGCGCAGAAAGCCGGAAAACCGCTGGTGGTAGAAGCCTGGGATCGCACCAACTCGAAGAAATTAAGTGAAGGCACGCTGTTAAGTCTAGATAACCAAATCGATGCCACTACCGGTACGATTAAAGTGAAAGCACGCTTTAATAATCAGGATGATGCGCTGTTTCCCAATCAGTTTGTTAACGCGCGCATGTTAGTCGACACCGAACAAAACGCCGTAGTGATCCCAACAGCCGCCCTGCAAATGGGCAATGAAGGCCATTTTGTCTGGGTGCTGAATAGCGAAAACAAGGTCAGCAAACATCTGGTGACGCCGGGCATTCAGGACAGTCAGAAAGTGGTGATCCGTGCAGGTATTTCTGCGGGCGATCGCGTGGTGACAGACGGCATTGATCGCCTGACCGAAGGGGCGAAAGTGGAAGTGGTGGAAGCCCAGAGCGCCACTACTCCGGAAGAGAAAGCCACCAGCCGCGAATACGCGAAAAAAGGAGCACGCTCCTGA", "partial": "0", "query_start": 86243, "query_end": 87295, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 29.04}, "gnl|BL_ORD_ID|2066|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexM", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2216", "ARO_accession": "3003704", "ARO_name": "mexM", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.6917e-35, "max_identities": 101, "bit_score": 129.028, "cvterm_id": "36752", "query": "VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "+R Q+ G + +    EG  ++AG  L  ID     A+ + A+   A  QA     +  ++RY+ L   + +S+Q  D   AT  Q  A + A  A +   R+ L+YT++TSP+SG++G   V  G LV+ G +  L +V Q+ PI V           L+QE          G+A V   + DG      G L   D  +D +TG+I +RA F N    L PG FV   L  G+  D L++  + V R   G+    V    D+VE   V   Q I D   V +GL SGD+V+V G  ++ PG  V  QE", "sequence_from_db": "IRTQIDGQLTRLLVSEGQMVEAGELLATIDDRAVVAALEQAQASRASNQAQLKSAEQDLQRYRSLYAERAVSRQLLDQQQATVDQLRATLKANDATINAERVRLSYTRITSPVSGKVGIRNVDVGNLVRVGDSLGLFSVTQIAPISV--------VFSLQQEQLLQLQALLGGEAAVRAYSRDGGSALGEGRLLTIDNQIDSSTGTIRVRASFDNRQARLWPGQFVAVSLHTGVRRDQLVLSSKAVRRGLEGNFVYRVA--DDRVEAVPVRVLQDI-DGLSVVEGLASGDQVVVDGHSRLMPGALVDIQE", "sequence_from_broadstreet": "MQALRSGGGRVLVGVLAAGLVAFGGWAWLGGDAGAKAAPAPARVPVIVARVERRDVEQQVSGIGTVTSLHNVVIRTQIDGQLTRLLVSEGQMVEAGELLATIDDRAVVAALEQAQASRASNQAQLKSAEQDLQRYRSLYAERAVSRQLLDQQQATVDQLRATLKANDATINAERVRLSYTRITSPVSGKVGIRNVDVGNLVRVGDSLGLFSVTQIAPISVVFSLQQEQLLQLQALLGGEAAVRAYSRDGGSALGEGRLLTIDNQIDSSTGTIRVRASFDNRQARLWPGQFVAVSLHTGVRRDQLVLSSKAVRRGLEGNFVYRVADDRVEAVPVRVLQDIDGLSVVEGLASGDQVVVDGHSRLMPGALVDIQEPRPSLAQATERRP", "dna_sequence_from_broadstreet": "ATGCAGGCGTTGCGCAGTGGTGGGGGACGGGTCCTGGTGGGCGTGCTGGCGGCGGGCCTGGTCGCCTTCGGCGGTTGGGCATGGCTCGGCGGCGACGCCGGGGCGAAGGCGGCGCCCGCGCCGGCCAGGGTCCCGGTGATCGTGGCGCGGGTGGAGCGGCGCGACGTCGAGCAACAGGTCAGCGGCATCGGCACGGTGACTTCGTTGCACAACGTGGTGATCCGCACCCAGATCGACGGCCAGTTGACCCGCCTGCTGGTGAGCGAAGGGCAGATGGTCGAGGCGGGCGAGTTACTGGCGACCATCGATGACCGCGCCGTCGTCGCCGCGCTGGAGCAGGCGCAGGCCTCCAGGGCGAGCAACCAGGCCCAGCTGAAATCCGCCGAGCAGGACCTGCAACGCTACCGCAGCCTGTATGCCGAGCGTGCGGTGTCACGCCAACTGCTGGACCAGCAGCAGGCGACGGTCGACCAGTTGCGCGCGACCCTGAAGGCCAACGATGCCACCATCAACGCCGAGCGGGTGCGCCTGTCCTACACCCGGATCACCTCGCCGGTATCCGGCAAGGTCGGTATCCGCAACGTCGATGTCGGCAACCTGGTGCGGGTCGGCGACAGTCTCGGCCTGTTCAGCGTGACCCAGATCGCACCGATCTCCGTAGTCTTCTCCCTGCAACAGGAACAGTTGCTCCAGTTGCAGGCGCTGCTCGGCGGCGAGGCGGCGGTGCGCGCCTACAGCCGCGACGGCGGGAGCGCGCTGGGCGAGGGCCGGTTGCTGACCATCGACAACCAGATCGACAGTTCCACCGGCACCATCCGCGTGCGCGCCTCCTTCGATAACCGCCAGGCCCGGCTCTGGCCCGGGCAGTTCGTCGCGGTGAGCCTGCACACCGGGGTCCGGCGCGACCAGTTGGTGCTGTCGAGCAAGGCGGTGCGCCGCGGCCTGGAGGGCAATTTCGTCTACCGGGTCGCCGACGACCGGGTCGAGGCGGTGCCGGTGCGGGTGCTCCAGGACATCGACGGCCTCAGTGTGGTGGAAGGCCTGGCCAGCGGTGACCAGGTGGTGGTGGACGGCCACTCGCGGCTGATGCCCGGCGCCCTGGTCGATATCCAGGAGCCGCGCCCGAGCCTGGCCCAGGCCACGGAGCGGCGGCCGTGA", "partial": "0", "query_start": 86357, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.58}, "gnl|BL_ORD_ID|2063|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexV", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2207", "ARO_accession": "3003030", "ARO_name": "MexV", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.05141e-20, "max_identities": 100, "bit_score": 89.3521, "cvterm_id": "36804", "query": "TELP--GRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYP-QSGTLEFSDVT--VDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGE----------GDKVEVRQVTASQA--IGDKW----LVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQ", "match": "+ LP  G   A++   +  +VSG +    F+ G  ++    L Q++    +A+  +A+ DL  A+A         +R ++L+G+K IS+ ++D   A   +++A V   KAA       LA  +V +P +G IG   V  G  V  G  T +AT+Q L  + +D      DF  L               ++ +LV      YP Q    E + +   VD  T ++ +RA   NPD  LLPGMF    +        ++VP+  +T T  GD S+ VVG+           DK + +QV   +   IG++     +V +GL+ G++V+ +G  K+  G  V    VA  D QQ", "sequence_from_db": "SRLPAIGSLKAFQGVTLTAEVSGTVRDVLFLSGDQVKLDQPLIQLESDVEEATLRTAEADLGLARA-------EYQRGRELIGSKAISKSEFDRLAAQWAKTSATVAELKAA-------LAKKRVLAPFAGTIGIRQVDVGDYVSPG--TPIATLQDLSTLLLDFHLPEQDFPLL---------------SRGQLVKVRVAAYPAQVFDAEIAAINPKVDNETRNLQVRAALENPDGKLLPGMFANLEVMLPGEEQRVVVPETAITFTLYGD-SIYVVGQKKDEQGQVSKDDKGQPQQVVERRFVRIGERREGLAVVLEGLEGGEQVVTSGQLKLDNGAAVAI--VAERDLQQ", "sequence_from_broadstreet": "MLLRRMLIMLAAVIAVVAILAGYKVYSIRQQIALFSAPKPPISVTASLAEKRPWQSRLPAIGSLKAFQGVTLTAEVSGTVRDVLFLSGDQVKLDQPLIQLESDVEEATLRTAEADLGLARAEYQRGRELIGSKAISKSEFDRLAAQWAKTSATVAELKAALAKKRVLAPFAGTIGIRQVDVGDYVSPGTPIATLQDLSTLLLDFHLPEQDFPLLSRGQLVKVRVAAYPAQVFDAEIAAINPKVDNETRNLQVRAALENPDGKLLPGMFANLEVMLPGEEQRVVVPETAITFTLYGDSIYVVGQKKDEQGQVSKDDKGQPQQVVERRFVRIGERREGLAVVLEGLEGGEQVVTSGQLKLDNGAAVAIVAERDLQQEH", "dna_sequence_from_broadstreet": "ATGTTGCTCCGCCGCATGTTGATCATGCTCGCCGCGGTGATCGCCGTGGTGGCGATTCTCGCCGGCTACAAGGTCTACTCCATCCGTCAGCAGATCGCCCTTTTCAGCGCACCGAAACCGCCGATCAGCGTGACCGCCAGCCTGGCCGAAAAGCGTCCCTGGCAGAGCCGCCTGCCAGCCATCGGCAGCCTCAAGGCATTCCAGGGCGTGACCCTCACCGCCGAAGTCTCCGGCACGGTACGCGACGTACTGTTCCTTTCCGGCGACCAGGTGAAGCTGGACCAACCGCTGATCCAGTTGGAAAGCGACGTCGAGGAAGCCACCCTGCGCACTGCCGAGGCCGATCTCGGCCTGGCCAGGGCCGAGTACCAGCGCGGCCGCGAACTGATCGGCAGCAAGGCCATCTCGAAAAGCGAATTCGATCGTCTCGCCGCGCAGTGGGCCAAGACCAGCGCCACCGTCGCCGAGCTGAAGGCGGCGCTGGCGAAGAAGCGCGTGCTCGCGCCCTTCGCCGGGACCATCGGCATCCGCCAGGTGGACGTCGGCGACTACGTCTCGCCCGGGACGCCGATCGCCACCTTGCAGGACCTTTCCACCCTGCTCCTGGATTTCCACCTGCCCGAGCAGGACTTCCCCCTGCTCAGCCGCGGCCAACTGGTGAAGGTCCGGGTCGCCGCCTACCCCGCCCAGGTGTTCGACGCCGAGATCGCCGCCATCAACCCCAAGGTCGACAACGAGACCCGCAACCTGCAGGTCCGCGCTGCCCTGGAGAACCCGGACGGCAAGCTGCTGCCGGGCATGTTCGCCAACCTCGAGGTGATGTTGCCTGGCGAGGAACAACGCGTCGTGGTCCCGGAGACGGCGATCACCTTCACCCTCTACGGCGACTCGATCTACGTCGTCGGGCAGAAGAAGGACGAGCAGGGCCAGGTGTCGAAGGATGACAAGGGCCAGCCGCAACAGGTCGTCGAGCGCCGCTTCGTCAGGATCGGCGAACGCCGCGAAGGCCTGGCGGTGGTGCTCGAAGGCCTTGAGGGCGGCGAGCAGGTAGTGACTTCCGGGCAACTGAAGCTCGACAACGGCGCCGCGGTGGCCATCGTCGCCGAGCGGGACCTCCAGCAAGAGCACTGA", "partial": "0", "query_start": 86315, "query_end": 87310, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 28.33}, "gnl|BL_ORD_ID|2049|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TriB", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "2193", "ARO_accession": "3003680", "ARO_name": "TriB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40296e-14, "max_identities": 97, "bit_score": 70.0922, "cvterm_id": "36804", "query": "LTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQ---SGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLE-----EGINPDALLVPQQGVTRTPRGDASVMVV-GEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVA", "match": "+ P ++  +   +L L+GC D+P     + +  V + TLK+  L       G   A   + +  + +G I  R F  G  +  G  L  +DP   Q    +++GDLA A+A     Q   +R ++L      +Q   D A    + S A+   AKAAV+ AR  L+YT++ +   G I       G +V  GQ    A V    P   +V ++  D   L  E+A      E+  A    + +  L  PQ   +G++       D +T +  +R            G  ++ +L        + P ++L+ + G T+       V VV G+   V +R+V        + ++  GL  GDRV+  G+  +KPG ++K  E A", "sequence_from_db": "MKPFSLAGLFGFALLLSGCGDEPPPAPPRPVLTVTVKTLKNDDL---GRFAGSIQARYESVLGFRTNGRIASRLFDVGDFVGKGALLATLDPTDQQNQLRASQGDLASAEAQLIDAQANARRQEELFARSVTAQARLDDARTRLKTSQASFDQAKAAVQQARDQLSYTRLVTDFDGVITTWHAEAGQVVSAGQ----AVVTLARP---EVREAVFD---LPTEVA------ESLPADARFLVSAQLD-PQARTTGSIRELGPQADASTRTRRVRLSLAQTPEAFRLGSTIQVQLSSAGSVRSVLPASVLLERDGKTQ-------VWVVDGKQSSVALREVQVLSRDERQVVIGQGLADGDRVVRAGVNSLKPGQKIKLDEDA", "sequence_from_broadstreet": "MKPFSLAGLFGFALLLSGCGDEPPPAPPRPVLTVTVKTLKNDDLGRFAGSIQARYESVLGFRTNGRIASRLFDVGDFVGKGALLATLDPTDQQNQLRASQGDLASAEAQLIDAQANARRQEELFARSVTAQARLDDARTRLKTSQASFDQAKAAVQQARDQLSYTRLVTDFDGVITTWHAEAGQVVSAGQAVVTLARPEVREAVFDLPTEVAESLPADARFLVSAQLDPQARTTGSIRELGPQADASTRTRRVRLSLAQTPEAFRLGSTIQVQLSSAGSVRSVLPASVLLERDGKTQVWVVDGKQSSVALREVQVLSRDERQVVIGQGLADGDRVVRAGVNSLKPGQKIKLDEDAR", "dna_sequence_from_broadstreet": "ATGAAGCCGTTTTCCCTCGCCGGCCTGTTCGGCTTCGCCCTGCTCCTCTCCGGCTGCGGCGACGAGCCGCCGCCGGCACCGCCGCGGCCGGTGCTGACGGTGACCGTGAAGACCCTGAAGAACGACGACCTCGGTCGCTTCGCCGGGAGCATCCAGGCGCGCTACGAGAGCGTGCTCGGCTTCCGCACCAACGGACGGATCGCCTCGCGCCTGTTCGACGTCGGTGACTTCGTCGGCAAGGGCGCGCTGCTGGCGACCCTCGACCCCACCGACCAGCAGAACCAGTTGCGCGCCAGCCAGGGCGACCTGGCCAGCGCCGAGGCACAGTTGATCGACGCCCAGGCCAATGCCCGGCGCCAGGAAGAACTGTTCGCCCGCAGCGTCACCGCCCAGGCGCGCCTGGACGATGCGCGGACCCGCCTGAAGACCAGCCAGGCCAGCTTCGACCAGGCCAAAGCGGCGGTGCAGCAGGCCAGGGACCAGCTTTCCTACACGCGCCTGGTGACCGATTTCGACGGCGTCATCACCACCTGGCACGCCGAGGCCGGGCAAGTGGTCAGCGCCGGCCAGGCGGTGGTCACCCTGGCCCGGCCCGAAGTGCGCGAGGCAGTCTTCGACCTGCCCACCGAGGTCGCCGAGAGCCTGCCGGCCGACGCGCGCTTCCTGGTCAGCGCCCAGCTCGACCCGCAGGCCAGGACCACCGGCAGCATCCGCGAGCTGGGTCCGCAGGCCGACGCCTCGACCCGCACCCGTCGCGTGCGCCTGAGCCTGGCGCAGACGCCGGAGGCGTTTCGCCTCGGTTCGACCATCCAGGTCCAGCTGAGCAGCGCCGGTAGCGTGCGCAGCGTGCTGCCGGCCAGCGTGCTGCTGGAGCGCGACGGCAAGACCCAGGTCTGGGTCGTCGATGGGAAACAGTCCAGCGTGGCCCTGCGCGAGGTACAGGTGCTCAGCCGCGACGAACGCCAGGTGGTGATCGGACAGGGCCTGGCCGACGGCGACCGGGTGGTCCGCGCCGGAGTCAACAGCCTCAAGCCCGGCCAGAAGATCAAACTCGACGAGGATGCGCGATGA", "partial": "0", "query_start": 86174, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 25.39}, "gnl|BL_ORD_ID|1620|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "ceoA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "730", "model_id": "1719", "ARO_accession": "3003009", "ARO_name": "ceoA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.56212e-12, "max_identities": 49, "bit_score": 62.7734, "cvterm_id": "36822", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQS", "match": "LAVV +  G+           ++ A  +PEV + T+    +       GR  A    +VRPQVSG I+  NF +G+ ++ G  L+ IDP  YQA  D A   LA AQA     Q   +R Q+L+G   I+++DYD     A+++", "sequence_from_db": "LAVVGL--GTFGAMRVSANAPEKAAAPLPEVDVATVVPQTVTDWQSYSGRLEAVEKVDVRPQVSGTIVAVNFKDGALVKKGDVLFVIDPRPYQAEVDRAAAQLAAAQARNGYAQTDWQRAQRLIGDNAIAKRDYDEKQNAAREA", "sequence_from_broadstreet": "MAILRTSRSRIATAAIVTLAVVGLGTFGAMRVSANAPEKAAAPLPEVDVATVVPQTVTDWQSYSGRLEAVEKVDVRPQVSGTIVAVNFKDGALVKKGDVLFVIDPRPYQAEVDRAAAQLAAAQARNGYAQTDWQRAQRLIGDNAIAKRDYDEKQNAAREAKREPEGRRSRAGNGAHQSRLYAHHRAGVGPRVARGNHARQRRVGRRVGRAADDAGIGVADLRVVRRRRADLPAIHQRRAQRPQGAGRARPRERNRLLAQRRDRFGRQPARHVVRHDPRARPLRQRGRHPGPGPLRTREGGRQRAARGAARRRRGDQHRPGQEVRVRRRPAGPRVVSRSAARDAARQPARDRERAVGRRPRGRERHAARASGRAGEAAHGPDDGRRCAVRAVASTAKPAAPAKADS", "dna_sequence_from_broadstreet": "ATGGCCATCCTACGCACCTCCCGTTCCCGAATCGCGACCGCGGCGATCGTCACGCTCGCCGTCGTCGGCCTCGGCACGTTCGGCGCGATGCGCGTGAGCGCGAACGCCCCCGAGAAAGCGGCGGCGCCGCTGCCCGAAGTCGACGTCGCGACCGTCGTGCCGCAGACCGTGACCGACTGGCAAAGCTATTCGGGCCGCCTCGAGGCGGTCGAGAAAGTCGACGTGCGCCCGCAGGTGTCGGGCACGATCGTCGCGGTGAACTTCAAGGACGGCGCGCTCGTGAAGAAAGGCGACGTGCTGTTCGTGATCGACCCGCGCCCGTACCAGGCGGAAGTCGACCGCGCCGCCGCGCAGCTCGCGGCCGCGCAGGCCCGCAACGGCTACGCGCAGACCGACTGGCAGCGCGCGCAGCGGCTGATCGGCGACAACGCGATCGCGAAGCGCGACTACGACGAGAAGCAGAACGCGGCGCGCGAAGCGAAACGCGAACCTGAAGGCCGCCGAAGCCGCGCTGGAAACGGCGCGCATCAATCTCGGCTATACGCGCATCACCGCGCCGGTGTCGGGCCGCGTGTCGCGCGCGGAAATCACGCTCGGCAACGTCGTGTCGGCCGGCGCGTCGGCCGCGCCGCTGACGACGCTGGTATCGGTGTCGCCGATCTACGCGTCGTTCGACGCCGACGAGCAGACCTACCTGCAATACATCAACGGCGCGCGCAGCGGCCGCAAGGTGCCGGTCGAGCTCGGCCTCGCGAACGAAACCGGCTACTCGCGCAGCGGCGAGATCGATTCGGTCGACAACCGGCTCGACACGTCGTCCGGCACGATCCGCGTGCGCGCCCGCTTCGACAACGCGGACGGCACCCTGGTCCCGGGCCTCTACGCACGCGTGAAGGTGGGCGGCAGCGCGCCGCACGAGGCGCTGCTCGTCGACGACGCGGCGATCAACACCGACCAGGACAAGAAGTTCGTGTTCGTCGTCGACCAGCAGGGCCGCGTGTCGTATCGCGAAGTGCAGCAAGGGATGCAGCACGGCAACCGGCGCGTGATCGTGAGCGGGCTGTCGGCCGGCGACCGCGTGGTCGTGAACGGCACGCAGCGCGTGCGTCCGGGCGAGCAGGTGAAGCCGCACATGGTCCCGATGACGGGCGGCGATGCGCCGTCCGCGCCGTCGCGAGCACCGCGAAGCCGGCCGCACCGGCGAAGGCGGATTCGTAA", "partial": "0", "query_start": 86183, "query_end": 86614, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 34.03}, "gnl|BL_ORD_ID|2048|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TriA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2192", "ARO_accession": "3003679", "ARO_name": "TriA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.26143e-11, "max_identities": 89, "bit_score": 62.003, "cvterm_id": "36804", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPIS----------GRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLE----FSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPG", "match": "+A+  +L   L L GC  +P    A+    V   T+K A     T + G   A   A+   +V G I++R    G  + AG  L ++DP   +++ ++A+  +A  QA + +  L  +R + LL   Y SQ +YD A+A+ + + +++ AA+A +  AR  L+YT++ +  +          G++ ++TV    L ++G+  A+  V      Y  +     D  R+   L        +GK +    T D     +SGTL+       V  + + GS+   ++    +H+++      +++ E   P   L+ QQG                  K  ++ V  ++   +K ++  GL++G  V+  G Q + PG", "sequence_from_db": "MALPAILCAGL-LVGCGAEPP---AEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNV------YESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVD----ERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGE--QPAVWLLDQQG------------------KARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPG", "sequence_from_broadstreet": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGEQPAVWLLDQQGKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASRDAVGGGQP", "dna_sequence_from_broadstreet": "ATGTCAGACGCCAGAGGCGCTTTTCATTCCAAAGGTCGCTGGTCGCGGATGGCGCTGCCCGCCATCCTGTGCGCCGGCCTGCTTGTCGGTTGCGGCGCCGAGCCGCCCGCCGAGGAACACGTCCGTGTGCTGGCGCAGACGGTGAAGATGGCCGAGTTCGCCTCGGCCACCTCGATCACCGGCGACATCCAGGCACGGGTACAGGCCGACCAGTCGTTCCGTGTCGGCGGCAAGATCGTCGAGCGCCTGGTCGATGTCGGCGACCACGTCGCGGCTGGCCAGGTGCTGGCGCGGCTCGACCCGCAGGACCAGCGCAGCAACGTGGAGAACGCCCAGGCGGCGGTCGCCGCGCAGCAGGCGCAGTCGAAGCTCGCCGACCTCAACTACCAGCGGCAGAAGGCGCTGCTGCCCAAGGGCTACACCAGCCAGAGCGAGTACGACCAGGCGCTGGCCTCGGTGCGCAGCGCGCAGAGTTCGCTGAAGGCCGCCCAGGCGCAGTTGGCCAACGCCCGCGACCTGCTTTCCTATACCGAGCTGCGTGCCTCCGACGCCGGGGTCATCACCGCCCGCCAGGCCGAGGTCGGCCAGGTGGTGCAGGCCACCGTGCCGATCTTCACCCTGGCCCGCGACGGCGAGCGCGACGCGGTGTTCAACGTCTACGAGTCGTTGTTCAGCCACGATGTCGACGGCCAGCGGATCACCGTCAGCCTGCTCGGCAAGCCGGAAGTCACCGCCAGCGGCAAGGTCCGCGAGATCACCCCCACGGTGGACGAGCGCAGCGGTACGCTGAAGGTCAAGGTCGGCCTCGACTCGGTGCCGGCGGAAATGAGCCTCGGCAGCGTGGTCAACGCCAGCGTCGCCGCGCCGGCCGAGCACAGCGTGGTGCTGCCCTGGTCGGCGCTGTCCAAGGTCGGCGAGCAGCCGGCGGTCTGGTTGCTCGACCAGCAAGGCAAGGCGCGTCTGCAACCGGTGCGGGTGGCACGCTACGCCAGCGAGAAGGTGGTCATCGACGGTGGCCTGGAGGCGGGCCAGACGGTGGTCACGGTGGGCGGCCAACTGCTCCATCCGGGCCAGGTGGTCGAGGTGGCCCAGCCGCCGCAGCCGACCCAGAGCACCGCCAGCCGCGACGCCGTGGGCGGAGGCCAGCCATGA", "partial": "0", "query_start": 86183, "query_end": 87265, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.73}, "gnl|BL_ORD_ID|2061|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexJ", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "690", "model_id": "2205", "ARO_accession": "3003692", "ARO_name": "MexJ", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.33857e-11, "max_identities": 83, "bit_score": 60.077, "cvterm_id": "36804", "query": "PLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQ-VTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "PL V L L  SL L  C +      A       IV       +++   PG   A    E+  ++ G +++R    G  ++    L ++DP   +   ++A+  ++ A+A     +   +RY+ LL    +S   ++    + +   A +   +A    A     Y  + SP  G I    V  G +V  GQT           + + + + S +  R+ Q ++            VEL +    ++  +G +       D  + +   R  F +       G   R  +        L VP   +T    G A V VV  G     RQ V       D+  V +GLK+GD V+ TG+Q ++ G QV+", "sequence_from_db": "PL-VALSLFSSLFLAACGNGTPPPAAARP---AIVVQPQPAGEVSQAFPGEIRARHEPELAFRIGGKVIRRLVEVGERVKKDQPLAELDPQDVRLQLEAARAQVSAAEANLQTVRAEYRRYRTLLDRNLVSHSQFENIQNSYRAGEARLKQIRAEFNVADNQAGYAVLRSPQDGVIASRRVEVGQVVAAGQTVFSLAADGEREVLIGLPEHSFERFRIGQPVS------------VELWSQRDRRF--AGHIRELSPAADPQSRTFAARVAFDDRATPAELGQSARVYV-AAAEAVPLSVPLSALT-AEAGQAFVWVVEPGSSTLRRQAVRTGPYAEDRVPVLEGLKAGDWVVATGVQVLREGQQVR", "sequence_from_broadstreet": "MYRHIPLVALSLFSSLFLAACGNGTPPPAAARPAIVVQPQPAGEVSQAFPGEIRARHEPELAFRIGGKVIRRLVEVGERVKKDQPLAELDPQDVRLQLEAARAQVSAAEANLQTVRAEYRRYRTLLDRNLVSHSQFENIQNSYRAGEARLKQIRAEFNVADNQAGYAVLRSPQDGVIASRRVEVGQVVAAGQTVFSLAADGEREVLIGLPEHSFERFRIGQPVSVELWSQRDRRFAGHIRELSPAADPQSRTFAARVAFDDRATPAELGQSARVYVAAAEAVPLSVPLSALTAEAGQAFVWVVEPGSSTLRRQAVRTGPYAEDRVPVLEGLKAGDWVVATGVQVLREGQQVRPIDRANRTVKLAAKE", "dna_sequence_from_broadstreet": "ATGTACCGCCATATCCCGCTCGTCGCCCTGTCCCTGTTTTCCTCCCTGTTCCTCGCCGCCTGCGGCAACGGCACGCCGCCGCCAGCCGCGGCGCGTCCGGCGATCGTCGTCCAGCCCCAGCCGGCGGGGGAGGTGAGCCAGGCCTTTCCCGGCGAGATCCGCGCCCGCCACGAGCCGGAGCTGGCCTTCCGCATCGGCGGCAAGGTCATCCGCCGGCTGGTGGAAGTCGGCGAGCGGGTAAAGAAGGACCAGCCCCTGGCCGAACTCGATCCCCAGGACGTGCGCCTGCAACTGGAGGCGGCGCGGGCCCAGGTCAGTGCCGCCGAGGCCAACTTGCAGACCGTGCGCGCCGAGTACCGGCGCTACCGCACCTTGCTCGACCGCAACCTGGTCAGCCATTCCCAGTTCGAGAACATCCAGAACAGCTACCGCGCCGGCGAGGCGCGGCTGAAGCAGATCCGCGCCGAATTCAACGTCGCCGACAACCAGGCCGGCTACGCCGTGCTGCGCTCGCCCCAGGATGGCGTGATCGCCAGCCGGCGCGTCGAGGTGGGCCAGGTGGTGGCGGCCGGACAGACGGTCTTCAGCCTGGCCGCCGACGGCGAACGCGAGGTGCTGATCGGCCTGCCGGAACACAGCTTCGAACGTTTCCGCATCGGCCAGCCGGTGTCGGTCGAACTCTGGTCGCAACGCGACAGACGCTTCGCCGGGCATATCCGCGAGCTCTCGCCCGCGGCCGATCCGCAATCGCGTACCTTCGCCGCCCGGGTGGCCTTCGACGACCGCGCGACTCCGGCCGAACTGGGCCAGAGCGCGCGGGTCTACGTCGCCGCCGCCGAGGCGGTGCCGTTATCGGTTCCCTTGTCGGCGCTGACCGCAGAGGCCGGCCAGGCGTTCGTCTGGGTGGTCGAGCCGGGCAGCTCGACCCTGCGCCGGCAGGCGGTGCGCACCGGTCCCTATGCCGAGGACCGGGTGCCGGTGCTCGAAGGCCTGAAGGCTGGCGACTGGGTGGTGGCCACCGGGGTCCAGGTGCTTCGCGAAGGGCAGCAGGTGCGTCCGATCGACCGGGCCAACCGCACGGTGAAACTGGCGGCCAAGGAGTAG", "partial": "0", "query_start": 86180, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 22.62}, "gnl|BL_ORD_ID|1584|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "macA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "760", "model_id": "1680", "ARO_accession": "3000533", "ARO_name": "macA", "ARO_category": {"36002": {"category_aro_accession": "0010001", "category_aro_cvterm_id": "36002", "category_aro_name": "ATP-binding cassette (ABC) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45684e-10, "max_identities": 83, "bit_score": 58.5362, "cvterm_id": "36806", "query": "TLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTV----KRYQK---LLGTKYISQQDYDTAVATAQ-------QSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTT-ALATVQQLDPIYVDVTQSSNDFLRLK--QELADGRLKQENGKAKVELVTND-GLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLE-EGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVT", "match": "T++   +  T    G  S   +  V  Q SG I K     G  ++ G  + +I+  T   + +  K  L   QA     Q+ +    K+Y++   L      S++D ++A            +  A +  +K ++ TA  +L YT++T+ + G +    V EG  V   Q+T  +  +  LD +   +  +  D  ++K  Q+++   L + +   K +L + D GL    SG    S  T          R+  PNPD  L  GM  +  +E +G+  + LL+P   V +   G A V V+G   K   R++           V  GLK GD+V+++", "sequence_from_db": "TVRRGGISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAEINSTTQTNTLNMEKSKLETYQAKLVSAQIALGSAEKKYKRQTALWKDDATSKEDLESAQDALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAV-YYYARSFVPNPDGKLATGMTTQNTVEIDGVK-NVLLIPSLTV-KNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVIS", "sequence_from_broadstreet": "MAKMMKWSAVAAVAAAAVWGGWHYLKPEPQAAYITETVRRGGISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAEINSTTQTNTLNMEKSKLETYQAKLVSAQIALGSAEKKYKRQTALWKDDATSKEDLESAQDALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLLIPSLTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR", "dna_sequence_from_broadstreet": "ATGGCGAAAATGATGAAATGGTCGGCTGTTGCGGCAGTCGCGGCGGCAGCGGTTTGGGGCGGATGGCATTATCTGAAGCCCGAACCGCAGGCTGCTTATATTACGGAAACGGTCAGGCGCGGCGGCATCAGCCGGACGGTTTCCGCGACGGGCGAGATTTCGCCGTCGAATCTGGTATCGGTCGGCGCGCAGGCTTCGGGGCAGATTAAAAAGCTTTATGTCAAACTCGGGCAACAGGTCAAAAAGGGAGATTTGATTGCGGAAATCAATTCGACCACGCAGACCAACACGCTCAATATGGAAAAATCTAAATTGGAAACGTATCAGGCGAAGCTGGTGTCGGCACAGATTGCATTGGGCAGCGCGGAGAAGAAATATAAGCGTCAGACGGCGTTGTGGAAGGATGATGCGACCTCTAAAGAAGATTTGGAAAGCGCGCAGGATGCGCTTGCCGCCGCCAAAGCCAATGTTGCCGAGTTGAAGGCTTTAATCAGACAGAGCAAAATTTCCATCAATACCGCCGAGTCGGATTTGGGCTACACGCGCATTACCGCGACGATGGACGGCACGGTGGTGGCGATTCCCGTGGAAGAGGGGCAAACCGTGAACGCGGCGCAGTCTACGCCGACGATTGTCCAATTGGCGAATCTGGATATGATGTTGAACAAAATGCAGATTGCCGAGGGCGATATTACCAAGGTGAAGGCGGGGCAGGATATTTCGTTTACGATTTTGTCCGAACCGGATACGCCGATTAAGGCGAAGCTCGACAGCGTCGACCCCGGGCTGACCACGATGTCGTCGGGCGGCTACAACAGCAGTACGGATACGGCTTCCAATGCGGTCTATTATTATGCCCGTTCGTTTGTGCCGAATCCGGACGGCAAACTCGCCACGGGGATGACGACGCAGAATACGGTTGAAATCGACGGTGTGAAAAATGTGTTGCTTATTCCGTCGCTGACCGTGAAAAATCGCGGCGGCAAGGCGTTCGTACGCGTGTTGGGTGCGGACGGCAAGGCGGCGGAACGCGAAATCCGGACCGGTATGAGAGACAGTATGAATACCGAAGTGAAAAGCGGGTTGAAAGAGGGGGACAAAGTGGTCATCTCCGAAATAACCGCCGCCGAGCAGCAGGAAAGCGGCGAACGCGCCCTAGGCGGCCCGCCGCGCCGATAA", "partial": "0", "query_start": 86285, "query_end": 87241, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 24.56}, "gnl|BL_ORD_ID|1263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "1344", "ARO_accession": "3000807", "ARO_name": "MexH", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.17017e-09, "max_identities": 65, "bit_score": 53.9138, "cvterm_id": "36804", "query": "KGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTA-LATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTG---SITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDK-VEVRQVTASQAIGDKW----LVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "+ +L + +A     ++   R +KL+     SQ+  D AVA    +  AV   +A ++   I        +P SG++G   V  G  +   +  A L   + L   +  + +S++  L+L Q L            +V +    G  +P   +       +D   G   ++ ++A+  NP+  L  GMF   R+    +  +L VP+  VT T  GD   +   +GD+ +  ++V+    IG++W     +  GL  GDRV+ +G   +  G+ V+", "sequence_from_db": "QAELIRLKAQLRNAEILHARARKLVERNVASQEQLDNAVAARDMALGAVRQTQALIDQKAIR-------APFSGQLGIRRVHLGQYLGVAEPVASLVDARTLKSNF-SLDESTSPELKLGQPL------------EVLVDAYPGRSFPARIS------AIDPLIGKSRTVQVQALLDNPEGLLAAGMFASIRVSRKADAPSLSVPETAVTYTAYGDTVFVAHQDGDRPLSAKRVSVR--IGERWDGRVEILQGLAEGDRVVTSGQINLSDGMAVE", "sequence_from_broadstreet": "MQKPVLIASAALICAAVIGIAVYATGSAKKDAGGFAGYPPVKVALASVERRVVPRVFDGVGELEAGRQVQVAAEAAGRITRIAFESGQQVQQGQLLVQLNDAVEQAELIRLKAQLRNAEILHARARKLVERNVASQEQLDNAVAARDMALGAVRQTQALIDQKAIRAPFSGQLGIRRVHLGQYLGVAEPVASLVDARTLKSNFSLDESTSPELKLGQPLEVLVDAYPGRSFPARISAIDPLIGKSRTVQVQALLDNPEGLLAAGMFASIRVSRKADAPSLSVPETAVTYTAYGDTVFVAHQDGDRPLSAKRVSVRIGERWDGRVEILQGLAEGDRVVTSGQINLSDGMAVEPVKEDTLSSAAPPVPVAGR", "dna_sequence_from_broadstreet": "ATGCAGAAACCCGTCCTGATCGCCAGTGCCGCGCTCATCTGCGCGGCGGTTATCGGCATCGCCGTCTACGCCACCGGCTCGGCGAAGAAAGACGCCGGCGGTTTCGCCGGCTACCCGCCGGTGAAGGTCGCCCTCGCCTCGGTGGAGCGGCGGGTGGTGCCGCGCGTCTTCGATGGCGTCGGCGAGCTGGAGGCCGGTCGCCAGGTCCAGGTGGCCGCCGAAGCGGCAGGACGGATCACCCGCATCGCCTTCGAATCGGGCCAGCAGGTGCAGCAAGGGCAGTTGCTGGTGCAACTCAACGACGCGGTGGAACAGGCCGAGCTGATCCGTCTCAAGGCGCAGTTGCGCAATGCCGAGATCCTCCATGCCCGTGCGCGCAAGCTGGTAGAGCGCAACGTCGCCTCGCAGGAACAGCTGGACAACGCCGTCGCCGCCCGCGACATGGCGCTCGGCGCGGTGCGCCAGACCCAGGCGCTGATCGACCAGAAGGCGATCCGCGCGCCCTTCTCCGGCCAGCTCGGCATCCGCCGCGTGCACCTCGGCCAGTACCTCGGCGTCGCCGAGCCGGTGGCCAGCCTGGTGGATGCGCGGACCCTGAAAAGCAATTTCTCCCTGGACGAAAGCACCAGTCCCGAGCTGAAGCTCGGCCAGCCCCTCGAGGTCCTGGTCGACGCCTATCCGGGGCGCAGCTTCCCGGCGCGCATCAGCGCCATCGACCCGCTGATCGGCAAGTCGCGCACGGTGCAGGTCCAGGCCTTGCTGGACAACCCCGAAGGCCTGCTCGCCGCCGGCATGTTCGCCAGCATCCGGGTCTCGCGCAAAGCCGACGCGCCGTCGCTGAGCGTGCCGGAAACCGCGGTCACCTATACCGCCTACGGCGACACCGTGTTCGTCGCCCACCAGGACGGCGACCGGCCGCTCAGCGCCAAGCGCGTCTCGGTGCGGATCGGCGAGCGCTGGGACGGTCGCGTGGAAATCCTCCAGGGCCTCGCCGAGGGCGACCGGGTAGTGACTTCCGGACAGATCAACCTGAGCGACGGGATGGCCGTGGAACCGGTCAAGGAAGACACCCTGAGCAGTGCCGCGCCCCCCGTGCCGGTCGCCGGCCGCTGA", "partial": "0", "query_start": 86480, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.64}, "gnl|BL_ORD_ID|1354|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtN", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "1442", "ARO_accession": "3003548", "ARO_name": "mdtN", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35965": {"category_aro_accession": "0000047", "category_aro_cvterm_id": "35965", "category_aro_name": "puromycin", "category_aro_description": "Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation.", "category_aro_class_name": "Antibiotic"}, "36174": {"category_aro_accession": "3000034", "category_aro_cvterm_id": "36174", "category_aro_name": "nucleoside antibiotic", "category_aro_description": "Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.02562e-06, "max_identities": 50, "bit_score": 44.669, "cvterm_id": "36839", "query": "PGRTSAYRIAE---VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLA----------------------------KAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQS-----NA----------------AVVAAKAAVET----ARINLAYTKVTSPISGRI", "match": "P    AY  A+   V P+VSG I++    +   ++ G  L++IDP  Y+A+   A+  LA                            KA+AAA     T++R + LL   ++S +D D A  TAQ++     NA                A+VA +AAVE      +++L    V +P  GR+", "sequence_from_db": "PSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRA-RTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRV", "sequence_from_broadstreet": "MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ", "dna_sequence_from_broadstreet": "ATGGAAAGTACGCCGAAAAAAGCTCCTCGCAGTAAATTCCCTGCTCTGTTAGTGGTTGCGTTGGCGCTGGTTGCCCTTGTTTTCGTTATCTGGCGCGTAGACAGTGCGCCATCAACTAATGACGCTTACGCGTCAGCAGATACCATTGATGTGGTACCGGAAGTCAGCGGCCGCATTGTAGAACTGGCGGTCACCGACAACCAGGCAGTCAAACAGGGCGATTTGCTGTTCCGCATCGACCCGCGCCCGTACGAAGCCAATCTGGCGAAAGCTGAAGCCTCCCTCGCGGCGCTGGATAAGCAAATTATGCTCACCCAGCGTAGCGTTGACGCGCAACAGTTTGGTGCCGACTCGGTTAATGCCACGGTAGAAAAAGCCCGTGCCGCCGCGAAACAGGCCACAGATACATTACGCCGCACCGAGCCATTACTGAAAGAAGGTTTTGTCTCAGCGGAAGATGTTGACCGTGCAAGAACGGCGCAGCGCGCCGCAGAAGCGGATCTTAATGCCGTATTGTTACAGGCGCAGTCAGCCGCCAGCGCCGTCAGCGGCGTGGATGCATTAGTTGCCCAGCGTGCGGCGGTCGAAGCGGATATTGCCCTGACCAAACTGCATCTGGAAATGGCGACCGTTCGCGCGCCGTTTGATGGCCGGGTCATTTCCCTCAAAACCTCCGTCGGGCAATTTGCTTCTGCCATGCGCCCTATTTTTACCCTAATCGACACTCGTCACTGGTATGTGATCGCCAACTTCCGCGAAACCGATCTGAAAAATATTCGCTCAGGTACACCCGCAACGATTCGCCTGATGAGTGACAGCGGCAAAACCTTCGAGGGTAAAGTGGATTCGATTGGCTACGGCGTGCTACCGGATGACGGCGGCCTGGTGCTGGGCGGCCTGCCGAAAGTGTCTCGTTCTATTAACTGGGTCCGCGTTGCCCAGCGTTTTCCGGTCAAAATCATGGTCGATAAACCTGACCCGGAAATGTTCCGCATCGGCGCTTCGGCAGTCGCTAATCTTGAGCCGCAATAA", "partial": "0", "query_start": 86324, "query_end": 86707, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 27.17}, "gnl|BL_ORD_ID|2786|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Klebsiella pneumoniae KpnG", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3298", "ARO_accession": "3004588", "ARO_name": "Klebsiella pneumoniae KpnG", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.00289322, "max_identities": 43, "bit_score": 35.8094, "cvterm_id": "42597", "query": "IDPATYQASYDSAKGDLAKAQA---------AANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNA--------------AVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVD", "match": "I+    QA+ D  K  L++AQA         AAN+  +  +  Q    T   +Q + D A+   QQ NA              AV+ A   V  A + L  T++ SPISG + + +V  GA  Q G TT L  V     +++D", "sequence_from_db": "INSKQLQANIDVKKTALSQAQADLNRRIPLGAANL--IGREELQHARDTVASAQAELDVAI---QQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGA--QIGTTTPLMAVVPATNLWID", "sequence_from_broadstreet": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "dna_sequence_from_broadstreet": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACTCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTCCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCTCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACTGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATCGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGTACCGGCAGCGCCTTCTCCCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGCCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "partial": "0", "query_start": 86441, "query_end": 86800, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 30.07}, "gnl|BL_ORD_ID|1329|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "AAC(2')-Id", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "1415", "ARO_accession": "3002526", "ARO_name": "AAC(2')-Id", "ARO_category": {"36480": {"category_aro_accession": "3000341", "category_aro_cvterm_id": "36480", "category_aro_name": "AAC(2')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 2'.", "category_aro_class_name": "AMR Gene Family"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0226012, "max_identities": 18, "bit_score": 32.3426, "cvterm_id": "36769", "query": "NPDALLVPQQGVTRTPRGDASVMV--VGEGDKVEV---RQVTASQAIGDKW", "match": " P ++L P +G+ RTP  D S+ V  V   D +E+   R++T     GD W", "sequence_from_db": "GPTSVLTPTEGIVRTPEDDRSLFVLPVDLPDGLELDTAREITCDWRSGDPW", "sequence_from_broadstreet": "MLTQHVSEARTRGAIHTARLIHTSDLDQETRDGARRMVIEAFRDPSGDSDFTDDFTDDDWDHALGGMHALISHHGALIAHGAVVQRRLMYRGPDGRGHALRCGYVEAVAVREDRRGDGLGTAVLDALEQVIRGAYQIGALSASDIARPMYIARGWLSWEGPTSVLTPTEGIVRTPEDDRSLFVLPVDLPDGLELDTAREITCDWRSGDPW", "dna_sequence_from_broadstreet": "GTGCTCACCCAGCATGTCAGTGAGGCTCGCACGCGCGGTGCGATCCACACCGCGCGTCTGATCCACACCTCCGATCTGGACCAGGAAACCCGCGACGGCGCGCGCCGCATGGTGATCGAGGCGTTCCGCGATCCGTCCGGAGACAGTGATTTCACCGACGATTTCACCGACGACGACTGGGACCACGCGCTCGGCGGCATGCACGCGCTGATCTCTCACCACGGTGCGCTCATCGCGCACGGCGCCGTCGTCCAACGTCGGTTGATGTACCGGGGACCCGACGGTAGAGGTCACGCGCTGCGCTGCGGTTACGTCGAGGCCGTCGCGGTGCGCGAGGACCGGCGGGGCGACGGTCTGGGCACCGCCGTGCTCGACGCGCTCGAGCAGGTGATCCGCGGCGCCTATCAGATCGGCGCGCTGAGCGCGTCGGACATCGCCCGGCCGATGTACATTGCCAGGGGCTGGCTGTCGTGGGAGGGTCCGACATCGGTGCTGACCCCCACCGAGGGCATCGTTCGCACCCCTGAGGACGACCGGTCGCTGTTCGTCCTGCCGGTCGATCTCCCGGACGGCCTCGAGTTGGACACCGCGCGCGAGATCACGTGCGACTGGCGCTCCGGCGACCCCTGGTGA", "partial": "0", "query_start": 87059, "query_end": 87196, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 35.29}, "gnl|BL_ORD_ID|569|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "emrK", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "609", "ARO_accession": "3000206", "ARO_name": "emrK", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.538308, "max_identities": 42, "bit_score": 28.4906, "cvterm_id": "35914", "query": "VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYI----SQQDYDTAVATAQQS---------------------NAAVVAAKA---------------------AVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQT", "match": "+  QVSG +   N  + + ++ G  L  +D      + + AK +LA      N   L  K+Y   + +  I    S +DY+  V  A+Q                      NAA+ A KA                     A + A + L  T + SP++G I + +V  G  V  GQ+", "sequence_from_db": "ISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQS", "sequence_from_broadstreet": "MELEDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVVPARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKNEDIAEMPELASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL", "dna_sequence_from_broadstreet": "ATGGAATTAGAAGACATGATTAGTACAGATGACGCCTATGTCACGGGGAATGCAGATCCAATTTCTGCACAAGTCTCAGGTAGTGTCACTGTCGTTAATCATAAAGATACGAACTACGTTCGACAAGGTGACATTTTAGTTTCACTGGATAAAACTGATGCCACTATCGCACTCAATAAAGCTAAAAATAATCTGGCAAATATTGTTCGGCAAACGAATAAACTATACTTACAGGATAAACAATACAGTGCCGAAGTCGCTTCAGCACGTATTCAGTATCAACAATCTTTAGAAGATTATAACCGTCGAGTGCCGTTAGCGAAGCAGGGGGTTATTTCAAAAGAAACGCTGGAGCATACCAAAGATACGTTAATAAGTAGCAAAGCGGCATTGAATGCCGCTATCCAGGCTTATAAAGCGAATAAAGCTTTAGTAATGAACACACCATTAAACCGTCAGCCACAAGTCGTTGAAGCGGCGGATGCAACTAAAGAAGCCTGGTTGGCGCTTAAACGTACGGATATTAAGAGTCCGGTTACCGGCTATATTGCCCAGAGAAGTGTTCAGGTCGGCGAAACAGTGAGCCCCGGACAATCGTTAATGGCTGTCGTACCGGCACGTCAAATGTGGGTTAATGCCAACTTTAAAGAAACACAACTCACGGATGTACGGATTGGTCAATCGGTCAATATTATCAGCGATCTTTATGGTGAAAATGTTGTGTTTCATGGTCGGGTGACAGGGATCAATATGGGAACCGGCAATGCGTTCTCCTTATTACCTGCACAAAATGCGACAGGGAACTGGATCAAAATCGTTCAGCGTGTACCGGTTGAAGTTTCTCTTGATCCAAAAGAACTCATGGAACACCCCTTGCGTATTGGTTTATCGATGACAGCAACTATTGATACGAAGAACGAAGACATTGCCGAGATGCCTGAGCTGGCTTCAACCGTGACCTCCATGCCGGCTTATACCAGTAAGGCTTTAGTTATCGATACCAGTCCGATAGAAAAAGAAATTAGCAACATTATTTCGCATAATGGACAACTTTAA", "partial": "0", "query_start": 86357, "query_end": 86755, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.46}, "gnl|BL_ORD_ID|2461|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "LpeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "680", "model_id": "2758", "ARO_accession": "3004099", "ARO_name": "LpeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.86306, "max_identities": 52, "bit_score": 26.1794, "cvterm_id": "41208", "query": "DLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDP--IYVDVTQSSNDFLRLKQELADGRLKQENGKAKVE-LVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQV", "match": "+LAKAQ          +R   L+ + Y+S ++        ++   A + A+  +   RI L   +  +P  G IG     EGA V  G++     V   DP  + VD     ++   L +      L +    + ++ ++  D    P    ++  D  +  TT S+ L     N                     + +++P Q +    R     + + +  K+ +  V       DK  + +GLK+G +++  G +++ P + V", "sequence_from_db": "ELAKAQ---------YERITPLIKSGYVSTKE-------VEEKKQAWIDAQKELSKTRIELDNLRFYAPFDGIIGAYKKREGAQVNAGESV----VSIYDPSALVVDFDIPCSNLATLNEGQPVYVLGKRYSLSHLQKMLDEDTHMCPADVDIQCDDCLIGATT-SVELLVAEKN---------------------NTIVIPFQAIFL--RNSKPFVYLVKKGKIVLASVKTGLQQEDKIEIVEGLKAGQQLVTKGQERLYPEMTV", "sequence_from_broadstreet": "MLGIQFNRGQWRSNYYWQIPVLIIAVISILFFISKKLFYSKVTPESIPNKLVEVEPIKSHNLQQTIHLLGTIHPKHATTLIAKESGMLDTLIPTGQKVTKGTLIAKINNPDLEKNLQLSLSAVELAKAQYERITPLIKSGYVSTKEVEEKKQAWIDAQKELSKTRIELDNLRFYAPFDGIIGAYKKREGAQVNAGESVVSIYDPSALVVDFDIPCSNLATLNEGQPVYVLGKRYSLSHLQKMLDEDTHMCPADVDIQCDDCLIGATTSVELLVAEKNNTIVIPFQAIFLRNSKPFVYLVKKGKIVLASVKTGLQQEDKIEIVEGLKAGQQLVTKGQERLYPEMTVDIYHPATSSS", "dna_sequence_from_broadstreet": "GTGTTAGGAATTCAATTCAATAGAGGTCAATGGCGGTCAAACTATTATTGGCAAATACCTGTGCTGATAATAGCTGTTATTAGCATTCTGTTTTTCATCAGTAAAAAATTATTCTACTCAAAAGTTACGCCAGAAAGCATACCTAATAAACTGGTGGAAGTTGAGCCCATTAAAAGCCACAACTTACAACAAACAATCCATTTATTAGGTACCATTCATCCAAAACACGCAACGACATTAATTGCTAAAGAATCAGGTATGTTGGACACCCTTATCCCAACTGGTCAAAAAGTCACAAAAGGGACACTTATTGCAAAAATCAACAACCCTGATCTTGAAAAAAATCTACAGCTTTCATTAAGTGCGGTAGAATTGGCAAAAGCACAATATGAACGTATCACCCCTTTAATTAAATCAGGATATGTCAGTACAAAGGAAGTCGAAGAAAAAAAACAAGCCTGGATTGATGCCCAAAAAGAATTATCAAAAACAAGGATTGAATTAGATAACCTCCGCTTTTACGCTCCTTTCGACGGAATAATTGGAGCATACAAAAAGAGAGAAGGAGCACAAGTCAATGCAGGTGAATCTGTTGTAAGTATTTACGACCCTTCTGCTTTAGTTGTCGATTTTGATATTCCTTGCAGTAATTTGGCAACTCTTAATGAAGGTCAGCCGGTTTATGTGCTGGGTAAACGGTATTCATTAAGTCATTTACAAAAAATGCTCGACGAAGACACCCACATGTGCCCTGCTGATGTTGATATTCAATGTGATGATTGTCTTATTGGTGCGACCACAAGTGTTGAGCTCCTTGTTGCGGAAAAAAATAACACTATTGTCATCCCCTTCCAGGCAATATTTTTGAGAAATAGTAAACCTTTTGTATATCTTGTAAAAAAGGGAAAGATTGTGCTTGCTTCAGTGAAAACTGGGTTGCAACAAGAGGATAAAATTGAAATTGTCGAGGGATTAAAAGCTGGGCAACAACTGGTTACAAAAGGCCAGGAACGCTTATATCCTGAAATGACCGTTGATATTTATCATCCAGCGACAAGTAGCAGCTAA", "partial": "0", "query_start": 86486, "query_end": 87274, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 19.55}, "gnl|BL_ORD_ID|1114|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "tetQ", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1183", "ARO_accession": "3000191", "ARO_name": "tetQ", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35986": {"category_aro_accession": "0000069", "category_aro_cvterm_id": "35986", "category_aro_name": "doxycycline", "category_aro_description": "Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome.", "category_aro_class_name": "Antibiotic"}, "36291": {"category_aro_accession": "3000152", "category_aro_cvterm_id": "36291", "category_aro_name": "minocycline", "category_aro_description": "Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome.", "category_aro_class_name": "Antibiotic"}, "36667": {"category_aro_accession": "3000528", "category_aro_cvterm_id": "36667", "category_aro_name": "chlortetracycline", "category_aro_description": "Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome.", "category_aro_class_name": "Antibiotic"}, "37011": {"category_aro_accession": "3000667", "category_aro_cvterm_id": "37011", "category_aro_name": "demeclocycline", "category_aro_description": "Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines.", "category_aro_class_name": "Antibiotic"}, "37012": {"category_aro_accession": "3000668", "category_aro_cvterm_id": "37012", "category_aro_name": "oxytetracycline", "category_aro_description": "Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.63946, "max_identities": 18, "bit_score": 25.409, "cvterm_id": "35916", "query": "NAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPI", "match": "NA++V     ++   INL    + + I    GK++VTE  L  +G T     V   D I", "sequence_from_db": "NASIVVYYCLIQMNIINLG---ILAHIDA--GKTSVTENLLFASGATEKCGRVDNGDTI", "sequence_from_broadstreet": "MRFDNASIVVYYCLIQMNIINLGILAHIDAGKTSVTENLLFASGATEKCGRVDNGDTITDSMDIEKRRGITVRASTTSIIWNGVKCNIIDTPGHMDFIAEVERTFKMLDGAVLILSAKEGIQAQTKLLFNTLQKLQIPTIIFINKIDRDGVNLERLYLDIKTNLSQDVLFMQTVVDGLVYPICSQTYIKEEYKEFVCNHDDNILERYLADSEISPADYWNTIIDLVAKAKVYPVLHGSAMFNIGINELLDAISSFILPPESVSNRLSAYLYKIEHDPKGHKRSFLKIIDGSLRLRDIVRINDSEKFIKIKNLKTIYQGREINVDEVGANDIAIVEDMEDFRIGDYLGTKPCLIQGLSHQHPALKSSVRPDRSEERSKVISALNTLWIEDPSLSFSINSYSDELEISLYGLTQKEIIQTLLEERFSVKVHFDEIKTIYKERPVKKVNKIIQIEVPPNPYWATIGLTLEPLPLGTGLQIESDISYGYLNHSFQNAVFEGIRMSCQSGLHGWEVTDLKVTFTQAEYYSPVSTPADFRQLTPYVFRLALQQSGVDILEPMLYFELQIPQAASSKAITDLQKMMSEIEDISCNNEWCHIKGKVPLNTSKDYASEVSSYTKGLGVFMVKPCGYQITKGDYSDNIRMNEKDKLLFMFQKSMSSK", "dna_sequence_from_broadstreet": "GTGCGTTTCGACAATGCATCTATTGTAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTGATGCAGGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGGCCGTGTGGATAATGGTGACACCATAACAGACTCTATGGATATAGAGAAACGTAGAGGAATTACTGTTCGGGCTTCTACGACATCTATTATCTGGAATGGAGTGAAATGCAATATCATTGACACTCCGGGACACATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCATCTTATCCGCAAAGGAAGGCATACAAGCGCAAACAAAGTTGCTGTTCAATACTTTACAAAAACTGCAAATCCCGACAATTATATTTATCAATAAAATTGACCGTGACGGTGTGAATTTAGAGCGTTTGTATCTGGATATAAAAACAAATCTGTCTCAAGATGTCCTGTTTATGCAAACTGTTGTCGATGGATTGGTTTATCCGATTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCATGACGACAATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATACGATAATCGATCTTGTGGCAAAAGCCAAAGTCTATCCGGTACTACATGGATCAGCAATGTTCAATATCGGTATCAATGAGTTGTTGGACGCCATCTCTTCTTTTATACTTCCTCCAGAATCAGTCTCAAACAGACTTTCAGCTTATCTCTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTCTAAAAATAATTGACGGAAGTCTGAGACTTCGAGACATTGTAAGAATCAACGATTCGGAAAAATTCATCAAGATTAAAAATCTAAAGACTATTTATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGGGCCAATGATATCGCGATTGTAGAAGATATGGAAGATTTTCGAATCGGAGATTATTTAGGTACTAAACCTTGTTTGATTCAAGGGTTATCTCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGACAGGTCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGACCCGTCTTTGTCCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTGACACAAAAGGAAATCATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAAGACTATCTACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCACCCAACCCTTACTGGGCCACAATAGGGCTGACGCTTGAACCCTTGCCGTTAGGGACAGGGTTGCAAATCGAAAGTGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGATTCGTATGTCTTGCCAATCTGGTTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACTCAAGCCGAGTATTATAGCCCGGTAAGTACACCTGCTGATTTCAGACAGCTGACCCCTTATGTCTTCAGGCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCAGATACCCCAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAAGACATCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAGACTACGCCTCAGAAGTAAGTTCATACACTAAGGGCTTAGGCGTTTTTATGGTCAAGCCATGCGGGTATCAAATAACAAAAGGCGATTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTATTCATGTTCCAAAAATCAATGTCATCAAAATAA", "partial": "0", "query_start": 86615, "query_end": 86791, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 30.51}, "gnl|BL_ORD_ID|1072|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TEM-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "1137", "ARO_accession": "3000957", "ARO_name": "TEM-90", "ARO_category": {"36023": {"category_aro_accession": "3000014", "category_aro_cvterm_id": "36023", "category_aro_name": "TEM beta-lactamase", "category_aro_description": "TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid.  Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.73227, "max_identities": 10, "bit_score": 24.6386, "cvterm_id": "35914", "query": "LKYPQSGTLEFSDVTVDQTTGSITLRAI", "match": "+ Y Q+  +E+S VT    TG +T+R +", "sequence_from_db": "IHYSQNDLVEYSPVTEKHLTGGMTVREL", "sequence_from_broadstreet": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTGGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW", "dna_sequence_from_broadstreet": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGGTGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "partial": "0", "query_start": 86909, "query_end": 86992, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 35.71}}, "NODE_6_length_262587_cov_42.4347_107 # 87372 # 90518 # 1 # ID=6_107;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.569": {"gnl|BL_ORD_ID|1035|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 87372, "orf_end": 90518, "orf_from": "NODE_6_length_262587_cov_42.4347_107", "model_name": "acrB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1104", "pass_evalue": "n/a", "pass_bitscore": "1900", "ARO_accession": "3000216", "ARO_name": "acrB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1941.39, "max_identities": 960, "cvterm_id": "36849", "query": "MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYPGADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDPDIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMNQDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNILLKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANALDTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIQKGSHG-ATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATILAIFFVPVFFVVVRRRFSKKSEDIEHSHQVEHH", "match": "MPNFFIDRPIFAWVIAIIIMLAGGL+ILKLPVAQYPTIAPPA++I+A YPGADA+TVQ+TVTQVIEQNMNGID+LMYMSSN DSTGT  ITLTFESGTD DIAQVQVQNKL LA PLLPQEVQQQG+SVEK+SSSFLMVVGVINT+GTM Q+DISDYVAANMKD ISRTSGVGDVQLFGSQYAMRIWM+PN+LN FQLTPVDVI+A+KAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLT+TEEFG ILLKVNQDGS+V LRDVAKIELGGE+YD++A+FNGQPASGLGIKLATGANALDTA AIRAELAKMEPFFPSG+KIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVF+PMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPI KG HG    GFFGWFNRMF+KSTHHYTDSVG ILRSTGRYLVLYLIIVVGMA+LFVRLPSSFLPDEDQGVF++M QLPAGATQERTQKVL+E+T+YYLTKEK+NVESVFAVNGFGFAGRGQNTGIAFVSLKDW+ RPGEENKVEAIT RA   FSQIKDAMVFAFNLPAIVELGTATGFDFELIDQ GLGHEKLTQARNQL    A+HPD+LT VRPNGLEDTPQFKIDIDQEKAQALGVSI+DINTTLGAAWGGSYVNDFIDRGRVKKVY+MSEAKYRMLP+DIG WYVR +DGQMVPFSAFS+SRWEYGSPRLERYNGLPS+EILGQAAPGKSTGEAM LME+LA KLP+G+GYDWTGMSYQERLSGNQAP+LYAISLIVVFLCLAALYESWSIPFSVMLVVPLGV+GALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLM+KEGKGLIEATL+AVRMRLRPILMTSLAFILGVMPLVIS+GAGSGAQNAVGTGVMGGMVTAT+LAIFFVPVFFVVVRRRFS+K+EDIEHSH V+HH", "sequence_from_db": "MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH", "sequence_from_broadstreet": "MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH", "dna_sequence_from_broadstreet": "ATGCCTAATTTCTTTATCGATCGCCCGATTTTTGCGTGGGTGATCGCCATTATCATCATGTTGGCAGGGGGGCTGGCGATCCTCAAACTGCCGGTGGCGCAATATCCTACGATTGCACCGCCGGCAGTAACGATCTCCGCCTCCTACCCCGGCGCTGATGCGAAAACAGTGCAGGACACGGTGACACAGGTTATCGAACAGAATATGAACGGTATCGATAACCTGATGTACATGTCCTCTAACAGTGACTCCACGGGTACCGTGCAGATCACCCTGACCTTTGAGTCTGGTACTGATGCGGATATCGCGCAGGTTCAGGTGCAGAACAAACTGCAGCTGGCGATGCCGTTGCTGCCGCAAGAAGTTCAGCAGCAAGGGGTGAGCGTTGAGAAATCATCCAGCAGCTTCCTGATGGTTGTCGGCGTTATCAACACCGATGGCACCATGACGCAGGAGGATATCTCCGACTACGTGGCGGCGAATATGAAAGATGCCATCAGCCGTACGTCGGGCGTGGGTGATGTTCAGTTGTTCGGTTCACAGTACGCGATGCGTATCTGGATGAACCCGAATGAGCTGAACAAATTCCAGCTAACGCCGGTTGATGTCATTACCGCCATCAAAGCGCAGAACGCCCAGGTTGCGGCGGGTCAGCTCGGTGGTACGCCGCCGGTGAAAGGCCAACAGCTTAACGCCTCTATTATTGCTCAGACGCGTCTGACCTCTACTGAAGAGTTCGGCAAAATCCTGCTGAAAGTGAATCAGGATGGTTCCCGCGTGCTGCTGCGTGACGTCGCGAAGATTGAGCTGGGTGGTGAGAACTACGACATCATCGCAGAGTTTAACGGCCAACCGGCTTCCGGTCTGGGGATCAAGCTGGCGACCGGTGCAAACGCGCTGGATACCGCTGCGGCAATCCGTGCTGAACTGGCGAAGATGGAACCGTTCTTCCCGTCGGGTCTGAAAATTGTTTACCCATACGACACCACGCCGTTCGTGAAAATCTCTATTCACGAAGTGGTTAAAACGCTGGTCGAAGCGATCATCCTCGTGTTCCTGGTTATGTATCTGTTCCTGCAGAACTTCCGCGCGACGTTGATTCCGACCATTGCCGTACCGGTGGTATTGCTCGGGACCTTTGCCGTCCTTGCCGCCTTTGGCTTCTCGATAAACACGCTAACAATGTTCGGGATGGTGCTCGCCATCGGCCTGTTGGTGGATGACGCCATCGTTGTGGTAGAAAACGTTGAGCGTGTTATGGCGGAAGAAGGTTTGCCGCCAAAAGAAGCTACCCGTAAGTCGATGGGGCAGATTCAGGGCGCTCTGGTCGGTATCGCGATGGTACTGTCGGCGGTATTCGTACCGATGGCCTTCTTTGGCGGTTCTACTGGTGCTATCTATCGTCAGTTCTCTATTACCATTGTTTCAGCAATGGCGCTGTCGGTACTGGTGGCGTTGATCCTGACTCCAGCTCTTTGTGCCACCATGCTGAAACCGATTGCCAAAGGCGATCACGGGGAAGGTAAAAAAGGCTTCTTCGGCTGGTTTAACCGCATGTTCGAGAAGAGCACGCACCACTACACCGACAGCGTAGGCGGTATTCTGCGCAGTACGGGGCGTTACCTGGTGCTGTATCTGATCATCGTGGTCGGCATGGCCTATCTGTTCGTGCGTCTGCCAAGCTCCTTCTTGCCAGATGAGGACCAGGGCGTGTTTATGACCATGGTTCAGCTGCCAGCAGGTGCAACGCAGGAACGTACACAGAAAGTGCTCAATGAGGTAACGCATTACTATCTGACCAAAGAAAAGAACAACGTTGAGTCGGTGTTCGCCGTTAACGGCTTCGGCTTTGCGGGACGTGGTCAGAATACCGGTATTGCGTTCGTTTCCTTGAAGGACTGGGCCGATCGTCCGGGCGAAGAAAACAAAGTTGAAGCGATTACCATGCGTGCAACACGCGCTTTCTCGCAAATCAAAGATGCGATGGTTTTCGCCTTTAACCTGCCCGCAATCGTGGAACTGGGTACTGCAACCGGCTTTGACTTTGAGCTGATTGACCAGGCTGGCCTTGGTCACGAAAAACTGACTCAGGCGCGTAACCAGTTGCTTGCAGAAGCAGCGAAGCACCCTGATATGTTGACCAGCGTACGTCCAAACGGTCTGGAAGATACCCCGCAGTTTAAGATTGATATCGACCAGGAAAAAGCGCAGGCGCTGGGTGTTTCTATCAACGACATTAACACCACTCTGGGCGCTGCATGGGGCGGCAGCTATGTGAACGACTTTATCGACCGCGGTCGTGTGAAGAAAGTTTATGTCATGTCAGAAGCGAAATACCGTATGCTGCCGGATGATATCGGCGACTGGTATGTTCGTGCTGCTGATGGTCAGATGGTGCCATTCTCGGCGTTCTCCTCTTCTCGTTGGGAGTACGGTTCGCCGCGTCTGGAACGTTACAACGGCCTGCCATCCATGGAAATCTTAGGCCAGGCGGCACCGGGTAAAAGTACCGGTGAAGCAATGGAGCTGATGGAACAACTGGCGAGCAAACTGCCTACCGGTGTTGGCTATGACTGGACGGGGATGTCCTATCAGGAACGTCTCTCCGGCAACCAGGCACCTTCACTGTACGCGATTTCGTTGATTGTCGTGTTCCTGTGTCTGGCGGCGCTGTACGAGAGCTGGTCGATTCCGTTCTCCGTTATGCTGGTCGTTCCGCTGGGGGTTATCGGTGCGTTGCTGGCTGCCACCTTCCGTGGCCTGACCAATGACGTTTACTTCCAGGTAGGCCTGCTCACAACCATTGGGTTGTCGGCGAAGAACGCGATCCTTATCGTCGAATTCGCCAAAGACTTGATGGATAAAGAAGGTAAAGGTCTGATTGAAGCGACGCTTGATGCGGTGCGGATGCGTTTACGTCCGATCCTGATGACCTCGCTGGCGTTTATCCTCGGCGTTATGCCGCTGGTTATCAGTACTGGTGCTGGTTCCGGCGCGCAGAACGCAGTAGGTACCGGTGTAATGGGCGGGATGGTGACCGCAACGGTACTGGCAATCTTCTTCGTTCCGGTATTCTTTGTGGTGGTTCGCCGCCGCTTTAGCCGCAAGAATGAAGATATCGAGCACAGCCATACTGTCGATCATCATTGA", "partial": "0", "query_start": 87372, "query_end": 90515, "orf_dna_sequence": "ATGCCTAATTTCTTTATCGATCGCCCCATATTTGCATGGGTGATCGCCATTATCATCATGCTGGCTGGGGGATTATCGATCCTCAAATTGCCGGTGGCGCAATATCCGACGATTGCGCCGCCAGCAATTTCCATTACCGCCATGTACCCCGGTGCTGACGCCGAAACGGTGCAGAACACCGTAACTCAGGTTATCGAACAGAATATGAACGGTATCGATCACCTGATGTACATGTCCTCAAATGGCGACTCCACCGGTACGGCAACCATTACGCTGACCTTCGAATCCGGTACCGATCCGGATATCGCCCAGGTTCAGGTTCAGAACAAGCTGGCGCTGGCGACGCCTCTGCTGCCGCAAGAAGTACAGCAGCAAGGGATTAGCGTTGAGAAAGCGTCCAGCAGCTTCCTGATGGTTGTCGGCGTCATTAACACCAACGGCACCATGAACCAGGACGATATTTCGGACTACGTGGCGGCCAACATGAAGGATCCGATTAGCCGTACCAGCGGCGTCGGCGACGTTCAGCTATTCGGTTCCCAGTATGCGATGCGTATCTGGATGGATCCAAACAAACTGAACAACTTCCAGCTTACGCCGGTGGATGTGATCAGCGCCCTGAAAGCGCAGAACGCCCAGGTGGCCGCGGGCCAGTTAGGCGGTACGCCGCCGGTGAAAGGCCAGCAGCTTAACGCCTCGATCATCGCGCAGACGCGTCTGACCAATACGGAAGAGTTTGGCAACATCCTGCTGAAGGTGAACCAGGACGGTTCCCAGGTTCGTCTGCGTGATGTCGCCAAAATTGAGCTGGGCGGCGAAAGCTATGACGTAGTGGCGAAGTTTAACGGCCAGCCGGCATCCGGTCTGGGTATTAAACTGGCTACCGGCGCGAACGCGCTGGATACCGCCAACGCTATTCGCGCTGAACTGGCGAAGATGGAGCCGTTTTTCCCGTCGGGGATGAAGATCGTTTACCCGTATGACACCACCCCGTTCGTGAAAATTTCTATTCACGAAGTGGTTAAAACGCTGGTGGAAGCGATCATCCTGGTGTTCCTGGTCATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCCACCATCGCGGTACCGGTGGTCCTGTTAGGCACCTTCGCGGTGCTGGCGGCGTTTGGCTTCTCGATAAACACCCTGACGATGTTCGGGATGGTGCTCGCCATCGGCCTGTTGGTGGATGACGCCATCGTGGTGGTAGAGAACGTCGAGCGCGTGATGGCGGAAGAGGGTCTGCCGCCGAAAGAAGCGACGCGTAAATCGATGGGACAGATTCAGGGCGCGCTGGTTGGTATCGCTATGGTGCTGTCGGCGGTATTTATCCCGATGGCGTTCTTCGGCGGCTCAACCGGGGCCATCTATCGCCAGTTCTCCATCACTATCGTTTCCGCGATGGCGCTGTCGGTACTGGTGGCGTTAATCCTGACGCCGGCGCTGTGCGCCACGATGCTGAAACCCATTCAGAAAGGCAGCCATGGCGCGACCACCGGCTTCTTCGGCTGGTTTAACCGCATGTTTGATAAGAGCACGCACCATTACACCGACAGCGTAGGCAACATTCTGCGCAGCACCGGTCGTTATCTGGTGCTGTATCTGATCATCGTGGTGGGTATGGCATGGCTGTTCGTCCGTCTGCCGAGCTCGTTCCTGCCGGACGAGGACCAGGGTGTATTCCTGAGTATGGCGCAGCTGCCTGCCGGCGCCACCCAGGAGCGTACGCAGAAAGTGCTGGATGAGATGACGAATTACTATCTCACCAAAGAGAAGGACAACGTGGAATCCGTGTTTGCGGTTAACGGCTTCGGTTTCGCCGGCCGCGGCCAGAACACCGGTATCGCGTTCGTTTCGCTGAAAGACTGGAGCCAGCGTCCGGGTGAGGAAAACAAAGTTGAAGCGATCACCGCGAGAGCAATGGGCTACTTCTCGCAGATTAAAGATGCGATGGTCTTCGCCTTTAACCTGCCGGCTATCGTTGAACTGGGTACCGCGACCGGCTTTGACTTCGAGCTGATTGACCAGGGCGGTCTGGGCCACGAAAAACTGACCCAGGCGCGTAACCAACTGTTTGGCATGGTGGCGCAGCATCCTGACGTGCTGACCGGCGTGCGCCCTAACGGTCTGGAAGATACACCGCAGTTTAAAATCGATATCGATCAGGAGAAAGCTCAGGCGCTGGGCGTCTCCATCAGCGACATTAACACCACGCTGGGCGCAGCCTGGGGCGGAAGCTATGTCAACGACTTTATCGACCGCGGCCGCGTGAAGAAAGTGTACATCATGTCCGAAGCGAAATACCGTATGCTGCCGGAAGATATCGGCAAGTGGTATGTTCGCGGCAGCGATGGTCAGATGGTGCCGTTCTCTGCTTTCTCGACCTCGCGTTGGGAATACGGTTCGCCGCGTCTGGAACGCTACAACGGTCTGCCGTCACTGGAAATCCTCGGTCAGGCCGCGCCAGGCAAGAGTACCGGTGAGGCGATGGCGCTGATGGAAGAGCTGGCGGGTAAACTGCCTTCCGGTATCGGCTACGACTGGACCGGGATGTCTTATCAGGAGCGACTGTCCGGCAACCAGGCCCCTGCCCTGTATGCCATCTCGCTGATTGTCGTCTTCCTGTGTCTGGCGGCGCTGTATGAGAGCTGGTCGATTCCGTTCTCGGTTATGCTGGTCGTCCCCTTGGGTGTGGTTGGTGCGCTGTTAGCCGCCACCTTCCGCGGGCTAACCAACGACGTTTACTTCCAGGTGGGTCTGCTGACCACCATCGGCCTGTCGGCGAAGAACGCAATATTGATCGTTGAATTCGCCAAAGACCTGATGGAGAAAGAGGGCAAAGGGCTGATTGAGGCGACGCTTGAAGCAGTACGTATGCGTCTACGTCCAATCCTGATGACATCTCTGGCGTTCATCCTCGGGGTAATGCCGCTAGTTATCAGCTCCGGCGCCGGCTCCGGTGCGCAGAACGCCGTCGGTACAGGCGTAATGGGCGGGATGGTGACCGCGACGATCCTGGCGATCTTCTTCGTGCCGGTGTTCTTTGTGGTGGTTCGTCGCCGCTTTAGCAAAAAATCGGAAGATATAGAGCACAGCCATCAGGTTGAGCATCATTAA", "orf_prot_sequence": "MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYPGADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDPDIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMNQDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNILLKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANALDTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIQKGSHGATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATILAIFFVPVFFVVVRRRFSKKSEDIEHSHQVEHH", "perc_identity": 91.52}}, "NODE_6_length_262587_cov_42.4347_234 # 216120 # 217280 # 1 # ID=6_234;partial=00;start_type=TTG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.621": {"gnl|BL_ORD_ID|2080|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 216120, "orf_end": 217280, "orf_from": "NODE_6_length_262587_cov_42.4347_234", "model_name": "Escherichia coli ampH", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3307", "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3004612", "ARO_name": "Escherichia coli ampH beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 690.263, "max_identities": 330, "cvterm_id": "42578", "query": "MKRSLLIFAALCAASWTSVQAAQPTVDPVFASDVVDRYANHIYYGSGATGMALVVIDGNQRVFRSFGETRPGNNQHPQLDSVIRIASLSKLMTSEMLVKLLDQGVVKLNDPLSKYAPPGARVPDWQGKPITLVNLATHTSALPREQPGGAAHRPVFVWPTRQQRWNWLSTATLKAAPGSQAAYSNLAFDLLADALATAAGKPYPQLFEEQITRPLGMKDTTFTPSPDQCQRLMIPEKGASPCNNTLAAIGSGGVYSTPGDMMRWMQQFLSSDFYTRSQQADRMQTLIYQRNQLTRVIGMDVPGRADALGLGWVYMKPKNGHPGIIQKTGGGGGFITYMAMNPQANVGAFVVVTRSPLTRFNNMSDGINDLVSELSGAQPNMQTAS", "match": "MKRSLL  A LCAAS TSV AAQP  +P FASD+VDRYA+HI+YGSGATGMALVVIDGNQRVFRS+GETRPGNN  PQLDSV+RIASL+KLMTSEMLVKLLDQG VKLNDPLSKYAPPGARVP + G PITLVNLATHTSALPREQPGGAAHRPVFVWPTR+QRW +LSTA LKAAPGSQAAYSNLAFDLLADALA A+GKPY QLFEEQITRPLGMKDTT+TPSPDQC+RLM+ E+GASPCNNTLAAIGSGGVYSTPGDMMRWMQQ+LSSDFY RS QADRMQTLIYQR Q T+VIGMDVPG+ADALGLGWVYM PK G PGIIQKTGGGGGFITYMAM PQ N+GAFVVVTRSPLTRF NMSDGINDLV+ELSG +P +  AS", "sequence_from_db": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "sequence_from_broadstreet": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "dna_sequence_from_broadstreet": "TTGAAACGTAGTCTGCTTTTTTCTGCCGTGCTGTGTGCGGCGTCATTGACCTCCGTCCATGCGGCGCAGCCGATCACTGAACCGGAGTTTGCCTCTGATATTGTCGATCGTTATGCCGATCATATTTTTTACGGCAGCGGTGCCACGGGGATGGCTCTGGTTGTTATCGACGGTAACCAGCGCGTCTTTCGCAGTTATGGCGAAACGCGACCTGGTAATAACGTTCGCCCGCAGCTGGATTCGGTCGTGCGTATTGCTTCCCTCACCAAGCTAATGACCAGTGAGATGCTGGTGAAATTGCTCGACCAGGGGACCGTGAAGTTAAACGATCCGCTAAGTAAATATGCTCCGCCAGGCGCACGCGTGCCAACCTACAATGGGACGCCCATTACGCTGGTCAATCTGGCAACCCATACCAGCGCCCTGCCCCGTGAACAGCCCGGTGGCGCGGCACATCGTCCGGTGTTTGTCTGGCCAACGCGCGAGCAACGCTGGAAATACCTTTCTACGGCGAAGCTGAAAGCCGCGCCAGGCAGTCAGGCGGCGTACTCTAACCTTGCGTTCGACCTGCTGGCAGATGCACTGGCGAATGCGTCCGGCAAGCCTTATACCCAGTTGTTTGAAGAGCAGATTACCCGTCCATTGGGGATGAAAGACACCACCTACACCCCCTCACCGGATCAGTGCCGCCGTTTAATGGTTGCTGAGCGCGGTGCCAGTCCGTGCAATAACACGCTGGCGGCAATTGGCAGCGGCGGCGTCTATTCCACGCCTGGCGATATGATGCGCTGGATGCAGCAGTATTTGTCATCTGATTTTTATCAGCGCAGTAACCAGGCAGATCGCATGCAGACGTTGATTTATCAGCGCGCGCAGTTTACGAAAGTGATTGGCATGGATGTCCCCGGCAAAGCGGATGCGCTTGGTTTAGGTTGGGTATATATGGCCCCGAAAGAGGGTCGTCCGGGGATTATTCAGAAGACAGGCGGTGGTGGCGGTTTCATTACCTATATGGCGATGATCCCGCAGAAGAATATTGGCGCGTTTGTGGTGGTCACTCGTTCGCCGTTGACGCGCTTTAAAAATATGAGCGATGGCATCAATGACCTGGTGACCGAGCTAAGCGGGAATAAACCGTTGGTTATCCCCGCGTCCTGA", "partial": "0", "query_start": 216120, "query_end": 217274, "orf_dna_sequence": "TTGAAACGTAGTTTGCTCATTTTTGCTGCGCTGTGCGCGGCGTCGTGGACCTCGGTGCAGGCCGCACAGCCTACCGTTGACCCGGTTTTCGCCTCGGATGTGGTCGATCGTTACGCCAATCATATCTACTACGGCAGCGGCGCCACCGGCATGGCGCTGGTGGTTATCGATGGCAATCAGCGTGTTTTTCGCAGCTTTGGCGAAACCCGCCCGGGGAATAATCAGCACCCGCAGCTCGACTCGGTGATCCGTATCGCCTCCCTCAGCAAACTGATGACCAGCGAGATGCTGGTGAAGCTGCTCGACCAGGGGGTGGTGAAACTCAACGATCCGCTGAGTAAATACGCCCCGCCGGGCGCCCGGGTGCCTGACTGGCAGGGAAAACCAATCACCCTGGTGAATCTCGCGACCCATACCAGCGCCCTGCCGCGCGAGCAGCCTGGTGGCGCCGCTCATCGTCCGGTGTTTGTCTGGCCGACCCGCCAGCAGCGCTGGAACTGGCTCTCTACCGCGACCCTGAAAGCCGCGCCGGGCTCGCAGGCGGCCTACTCCAACCTGGCCTTCGATTTACTGGCAGACGCGCTCGCCACCGCCGCCGGCAAACCGTATCCGCAGCTGTTTGAAGAGCAGATCACCCGGCCGCTGGGGATGAAGGACACCACCTTTACCCCGTCACCGGATCAGTGCCAGCGGCTGATGATCCCGGAAAAAGGCGCCAGCCCATGCAACAACACCCTGGCGGCGATCGGCAGCGGCGGAGTCTACTCGACGCCGGGGGATATGATGCGCTGGATGCAGCAGTTCCTGTCATCCGATTTCTATACCCGCAGCCAGCAGGCCGACCGGATGCAGACGCTGATTTATCAGCGTAACCAGCTGACCCGGGTGATTGGTATGGACGTGCCGGGCCGCGCCGACGCGCTGGGCCTCGGCTGGGTGTATATGAAGCCGAAGAACGGCCATCCGGGGATTATTCAGAAAACCGGCGGCGGCGGCGGGTTTATCACCTATATGGCGATGAATCCGCAGGCTAACGTTGGCGCCTTTGTGGTGGTAACCCGCTCGCCGTTGACCCGCTTCAACAATATGAGCGATGGCATCAACGACCTGGTCAGCGAGCTGAGCGGCGCACAGCCCAACATGCAGACGGCCAGCCAGTAA", "orf_prot_sequence": "MKRSLLIFAALCAASWTSVQAAQPTVDPVFASDVVDRYANHIYYGSGATGMALVVIDGNQRVFRSFGETRPGNNQHPQLDSVIRIASLSKLMTSEMLVKLLDQGVVKLNDPLSKYAPPGARVPDWQGKPITLVNLATHTSALPREQPGGAAHRPVFVWPTRQQRWNWLSTATLKAAPGSQAAYSNLAFDLLADALATAAGKPYPQLFEEQITRPLGMKDTTFTPSPDQCQRLMIPEKGASPCNNTLAAIGSGGVYSTPGDMMRWMQQFLSSDFYTRSQQADRMQTLIYQRNQLTRVIGMDVPGRADALGLGWVYMKPKNGHPGIIQKTGGGGGFITYMAMNPQANVGAFVVVTRSPLTRFNNMSDGINDLVSELSGAQPNMQTASQ", "perc_identity": 85.71}}, "NODE_8_length_247415_cov_40.5207_219 # 227800 # 229548 # -1 # ID=8_219;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.567": {"gnl|BL_ORD_ID|2249|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 227800, "orf_end": 229548, "orf_from": "NODE_8_length_247415_cov_40.5207_219", "model_name": "msbA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2423", "pass_evalue": "n/a", "pass_bitscore": "1000", "ARO_accession": "3003950", "ARO_name": "msbA", "ARO_category": {"36002": {"category_aro_accession": "0010001", "category_aro_cvterm_id": "36002", "category_aro_name": "ATP-binding cassette (ABC) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes.", "category_aro_class_name": "AMR Gene Family"}, "37033": {"category_aro_accession": "3000689", "category_aro_cvterm_id": "37033", "category_aro_name": "metronidazole", "category_aro_description": "Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death.", "category_aro_class_name": "Antibiotic"}, "41239": {"category_aro_accession": "3004115", "category_aro_cvterm_id": "41239", "category_aro_name": "nitroimidazole antibiotic", "category_aro_description": "Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1126.69, "max_identities": 540, "cvterm_id": "36849", "query": "MQNDKDLSTWQTFRRLWPIIAPFKAGLIVAAVALVLNAGSDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMVLRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSLILIVLAPIVSVAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLKFENVTFTYPGREVAALRNINLDIPEGKTVALVGRSGSGKSTIASLITRFYDVDEGQILLDGHDLREYKLSSLRDQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVMLSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGRIVERGTHHDLLEHKGVYAQLHKMQFGE", "match": "M NDKDLSTWQTFRRLWP IAPFKAGLIVA VAL+LNA SDTFMLSLLKPLLDDGFGKTDRSVL+WMPLVVIGLM+LRGITSY+SSYCISWVSGKVVMTMRRRLFGHMMGMPV+FFDKQSTGTLLSRITYDSEQVASSSS ALITVVREGASIIGLF+MMFYYSWQLS+ILIVLAPIVS+AIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVL+FGGQEVETKRFDKVSN+MRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMD+LTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLF ILDSEQEKDEG RVIERA G+++F NVTFTYPGR+V ALRNINL IP GKTVALVGRSGSGKSTIASLITRFYD+DEG+IL+DGHDLREY L+SLR+QVALVSQNVHLFNDTVANNIAYARTE+YSREQIEEAARMAYAMDFINKMDNGLDT+IGENGV+LSGGQRQRIAIARALLR+SPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIE+ADEIVVVEDG IVERGTH+DLLEH+GVYAQLHKMQFG+", "sequence_from_db": "MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ", "sequence_from_broadstreet": "MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ", "dna_sequence_from_broadstreet": "ATGCATAACGACAAAGATCTCTCTACGTGGCAGACATTCCGCCGACTGTGGCCAACCATTGCGCCTTTCAAAGCGGGTCTGATCGTGGCGGGCGTAGCGTTAATCCTCAACGCAGCCAGCGATACCTTCATGTTATCGCTCCTTAAGCCACTTCTTGATGATGGCTTTGGTAAAACAGATCGCTCCGTGCTGGTGTGGATGCCGCTGGTGGTGATCGGGCTGATGATTTTACGTGGTATCACCAGCTATGTCTCCAGCTACTGTATCTCCTGGGTATCAGGAAAGGTGGTAATGACCATGCGTCGCCGCCTGTTTGGTCACATGATGGGAATGCCAGTTTCATTCTTTGACAAACAGTCAACGGGTACGCTGTTGTCACGTATTACCTACGATTCCGAACAGGTTGCTTCTTCTTCTTCCGGCGCACTGATTACTGTTGTGCGTGAAGGTGCGTCGATCATCGGCCTGTTCATCATGATGTTCTATTACAGTTGGCAACTGTCGATCATTTTGATTGTGCTGGCACCGATTGTTTCGATTGCGATTCGCGTTGTATCGAAGCGTTTTCGCAACATCAGTAAAAACATGCAGAACACCATGGGGCAGGTGACCACCAGCGCAGAACAAATGCTGAAGGGCCACAAAGAAGTATTGATTTTCGGTGGTCAGGAAGTGGAAACGAAACGCTTTGATAAAGTCAGCAACCGAATGCGTCTTCAGGGGATGAAAATGGTTTCAGCCTCTTCCATCTCTGATCCGATCATTCAGCTGATCGCCTCTTTGGCGCTGGCGTTTGTTCTGTATGCGGCGAGCTTCCCAAGTGTCATGGATAGCCTGACTGCCGGTACGATTACCGTTGTTTTCTCTTCAATGATTGCACTGATGCGTCCGCTGAAATCGCTGACCAACGTTAACGCCCAGTTCCAGCGCGGTATGGCGGCTTGTCAGACGCTGTTTACCATTCTGGACAGTGAGCAGGAGAAAGATGAAGGTAAGCGCGTGATCGAGCGTGCGACTGGCGACGTGGAATTCCGCAATGTCACCTTTACTTATCCGGGACGTGACGTACCTGCATTGCGTAACATCAACCTGAAAATTCCGGCAGGGAAGACGGTTGCTCTGGTTGGACGCTCTGGTTCGGGTAAATCAACCATCGCCAGCCTGATCACGCGTTTTTACGATATTGATGAAGGCGAAATCCTGATGGATGGTCACGATCTGCGCGAGTATACCCTGGCGTCGTTACGTAACCAGGTTGCTCTGGTGTCGCAGAATGTCCATCTGTTTAACGATACGGTTGCTAACAACATTGCTTACGCACGGACTGAACAGTACAGCCGTGAGCAAATTGAAGAAGCGGCGCGTATGGCCTACGCCATGGACTTCATCAATAAGATGGATAACGGTCTCGATACAGTGATTGGTGAAAACGGCGTGCTGCTCTCTGGCGGTCAGCGTCAGCGTATTGCTATCGCTCGAGCCTTGTTGCGTGATAGCCCGATTCTGATTCTGGACGAAGCTACCTCGGCTCTGGATACCGAATCCGAACGTGCGATTCAGGCGGCACTGGATGAGTTGCAGAAAAACCGTACCTCTCTGGTGATTGCCCACCGCTTGTCTACCATTGAAAAGGCAGACGAAATCGTGGTCGTCGAGGATGGTGTCATTGTGGAACGCGGTACGCATAACGATTTGCTTGAGCACCGCGGCGTTTACGCGCAACTTCACAAAATGCAGTTTGGCCAATGA", "partial": "0", "query_start": 227800, "query_end": 229545, "orf_dna_sequence": "ATGCAGAACGATAAAGATCTCTCCACGTGGCAGACCTTCCGCCGACTTTGGCCGATTATCGCGCCGTTTAAAGCCGGGCTAATCGTAGCGGCGGTGGCGTTGGTGCTTAACGCGGGCAGTGACACCTTCATGTTATCGCTTCTTAAACCGTTATTGGATGATGGTTTTGGTAAAACGGATCGCTCAGTGCTGCTATGGATGCCGCTGGTGGTTATCGGCCTGATGGTGCTGCGTGGGATCACCAGCTACATCTCGAGCTATTGTATTTCCTGGGTTTCCGGCAAAGTGGTGATGACCATGCGTCGTCGCCTGTTCGGCCACATGATGGGTATGCCGGTGGCCTTCTTTGACAAGCAGTCTACCGGAACGCTGCTGTCACGCATCACCTATGATTCTGAGCAGGTCGCCTCCTCTTCTTCCAGCGCGCTGATCACCGTGGTCCGCGAAGGAGCATCGATTATCGGTCTGTTCGTGATGATGTTCTATTACAGCTGGCAGCTGTCGCTGATCCTGATCGTACTGGCGCCGATTGTGTCGGTGGCGATCCGCGTGGTCTCCAAGCGTTTTCGCAATATCAGTAAGAATATGCAGAACACGATGGGGCAGGTCACCACCAGCGCCGAGCAGATGCTGAAAGGGCACAAAGAGGTGCTGATGTTTGGCGGCCAGGAAGTGGAAACCAAACGTTTTGATAAAGTCAGCAATAAAATGCGTCTGCAGGGGATGAAGATGGTTTCCGCCTCGTCTATCTCCGACCCGATCATTCAGCTTATCGCCTCCCTGGCGCTGGCCTTTGTCCTGTATGCCGCCAGCTTCCCGAGCGTGATGGACACCCTGACCGCCGGGACCATTACCGTGGTCTTCTCCTCGATGATTGCGCTGATGCGTCCGCTGAAGTCGCTGACCAACGTCAATGCCCAGTTCCAGCGCGGGATGGCGGCGTGCCAGACGCTGTTTGCGATCCTCGATTCCGAGCAGGAAAAAGACGAAGGTACGCGGGTCATTGAGCGGGCGAAAGGCAATCTCAAGTTCGAGAACGTCACCTTTACCTACCCGGGTCGCGAAGTGGCCGCGCTGCGCAATATCAATCTCGATATCCCGGAAGGGAAAACAGTGGCGCTGGTGGGGCGCTCAGGGTCGGGTAAATCGACCATTGCCAGCCTGATCACCCGCTTCTACGATGTCGACGAGGGGCAGATCCTGCTGGATGGCCACGACCTGCGCGAGTACAAGCTGAGCTCGCTGCGCGACCAGGTGGCGCTGGTTTCACAAAACGTGCATCTGTTCAACGATACCGTCGCCAACAATATCGCCTATGCCCGTACCGAAGAGTACAGCCGCGAGCAGATTGAAGAGGCCGCGCGCATGGCCTACGCCATGGATTTCATTAACAAGATGGATAATGGTCTGGATACCATCATCGGCGAGAATGGCGTGATGCTGTCCGGCGGCCAGCGCCAGCGTATTGCTATTGCCCGCGCGCTGCTGCGTAACAGCCCGATCCTGATCCTCGATGAAGCCACCTCGGCGCTGGATACCGAGTCCGAGCGTGCTATTCAGGCGGCGCTGGATGAGCTGCAGAAAAACCGTACCTCGCTGGTTATCGCTCACCGTCTGTCGACCATTGAGCAGGCTGATGAAATCGTGGTGGTTGAAGACGGGCGGATCGTGGAGCGCGGAACGCACCATGACCTGCTGGAGCATAAGGGCGTGTACGCCCAGCTGCATAAGATGCAATTCGGCGAATGA", "orf_prot_sequence": "MQNDKDLSTWQTFRRLWPIIAPFKAGLIVAAVALVLNAGSDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMVLRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSLILIVLAPIVSVAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLKFENVTFTYPGREVAALRNINLDIPEGKTVALVGRSGSGKSTIASLITRFYDVDEGQILLDGHDLREYKLSSLRDQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVMLSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGRIVERGTHHDLLEHKGVYAQLHKMQFGE", "perc_identity": 92.78}}, "NODE_9_length_203843_cov_42.4911_20 # 15303 # 15935 # 1 # ID=9_20;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.518": {"gnl|BL_ORD_ID|818|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 15303, "orf_end": 15935, "orf_from": "NODE_9_length_203843_cov_42.4911_20", "model_name": "CRP", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "869", "pass_evalue": "n/a", "pass_bitscore": "400", "ARO_accession": "3000518", "ARO_name": "CRP", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35930": {"category_aro_accession": "0000011", "category_aro_cvterm_id": "35930", "category_aro_name": "cloxacillin", "category_aro_description": "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections.", "category_aro_class_name": "Antibiotic"}, "35973": {"category_aro_accession": "0000056", "category_aro_cvterm_id": "35973", "category_aro_name": "oxacillin", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.31251e-158, "bit_score": 432.95, "max_identities": 208, "cvterm_id": "36839", "query": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "match": "MVLGKPQTDPTLEWFLSHCHIHKYPSKS LIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLS+QMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "sequence_from_db": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "sequence_from_broadstreet": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "dna_sequence_from_broadstreet": "ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAAGAGCAAGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAGACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGCCAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGATTCAGGTAAACCCGGACATTCTGATGCGTTTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCAACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAATCTGGCAAAACAACCAGACGCTATGACTCACCCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATTGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCATTCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTTAA", "partial": "0", "query_start": 15303, "query_end": 15932, "orf_dna_sequence": "ATGGTGCTTGGCAAACCGCAAACAGACCCTACCCTTGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCAAAGAGCACGCTGATCCACCAGGGTGAAAAAGCAGAAACGCTGTACTACATCGTTAAAGGCTCCGTGGCTGTACTCATCAAGGATGAAGAAGGTAAAGAGATGATCCTCTCCTACCTCAACCAGGGCGATTTCATCGGTGAATTAGGCCTGTTTGAAGAGGGTCAGGAACGTAGCGCCTGGGTACGGGCGAAAACCGCATGTGAAGTGGCCGAAATCTCTTATAAGAAATTCCGTCAGCTGATCCAGGTGAACCCGGACATTCTGATGCGTCTCTCTTCGCAAATGGCTCGCCGTCTGCAGGTCACGTCTGAGAAAGTGGGCAACCTGGCCTTCCTCGACGTGACGGGCCGTATCGCCCAGACGCTGCTGAACCTGGCGAAGCAACCGGATGCCATGACCCACCCGGACGGTATGCAAATTAAAATTACCCGCCAGGAAATTGGTCAGATCGTCGGCTGCTCTCGTGAAACCGTTGGTCGTATTTTGAAAATGCTGGAAGATCAGAACCTGATTTCCGCGCACGGTAAAACCATCGTCGTCTACGGCACCCGTTAA", "orf_prot_sequence": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "perc_identity": 99.05}}, "NODE_9_length_203843_cov_42.4911_123 # 130217 # 131200 # -1 # ID=9_123;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.603": {"gnl|BL_ORD_ID|1977|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 130217, "orf_end": 131200, "orf_from": "NODE_9_length_203843_cov_42.4911_123", "model_name": "pmrF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2014", "pass_evalue": "n/a", "pass_bitscore": "550", "ARO_accession": "3003578", "ARO_name": "PmrF", "ARO_category": {"41433": {"category_aro_accession": "3004269", "category_aro_cvterm_id": "41433", "category_aro_name": "pmr phosphoethanolamine transferase", "category_aro_description": "This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane.", "category_aro_class_name": "AMR Gene Family"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 577.785, "max_identities": 272, "cvterm_id": "36849", "query": "MLTYPPVKKVSVVIPVYNEQDSLPELLRRTDAACATLGRQYEILLIDDGSSDDSARMLTEAAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSIFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHERSTFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSIFGSVIALLGFAFGLLLVVLRLAFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYNDVRARPRYFIQRVVRQPETASKEED", "match": "M    PVKKVSVVIPVYNEQ+SLPEL+RRT  AC +LG++YEILLIDDGSSD+SA ML EA++AE SH+V++LLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDS FRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHI+DAML+CHERSTFIPILAN FARRA+EIPV HAEREFG+SKYSFMRLINLMYDLVTCLTTTPLR+LS+ GS+IA+ GF+  +LLV+LRL FGPQWAAEGVFMLFAVLF FIGAQF+GMGLLGEYIGRIY DVRARPRYF+Q+V+R    +SKE +", "sequence_from_db": "MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIR---PSSKENE", "sequence_from_broadstreet": "MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE", "dna_sequence_from_broadstreet": "ATGTTTGAAATCCACCCTGTTAAGAAAGTCTCGGTGGTTATTCCCGTTTATAACGAGCAGGAAAGCTTACCGGAATTAATCAGGCGCACCACCACAGCCTGTGAATCGTTGGGGAAAGAGTATGAGATCCTGCTGATTGATGACGGCAGTAGCGATAATTCCGCGCATATGCTGGTCGAAGCCTCACAAGCGGAGAACAGCCATATTGTGTCTATTTTGCTTAACCGCAATTACGGGCAACATTCAGCGATTATGGCGGGATTCAGTCACGTTACTGGCGACTTAATTATTACCCTTGATGCCGATCTCCAGAATCCGCCAGAAGAAATCCCCCGCCTGGTGGCAAAAGCCGATGAAGGTTACGACGTGGTAGGGACTGTACGCCAGAACCGCCAGGACAGCTGGTTTCGTAAAACCGCTTCGAAGATGATTAACCGGCTTATTCAGCGCACCACTGGCAAAGCGATGGGTGATTACGGTTGTATGCTGCGCGCCTATCGCCGTCATATTGTCGATGCGATGTTGCACTGCCATGAACGCAGCACCTTTATCCCGATTCTGGCGAATATCTTCGCCCGCCGTGCCATTGAAATTCCAGTACATCATGCCGAGCGTGAGTTTGGTGAATCCAAATACAGTTTTATGCGCCTGATTAATTTGATGTACGACCTGGTGACCTGCCTTACCACAACGCCGCTACGTATGCTGAGTCTGCTCGGCAGCATTATTGCGATTGGAGGTTTTAGCATTGCGGTGCTGCTGGTGATTTTACGCCTGACCTTCGGACCACAATGGGCGGCAGAAGGCGTCTTTATGCTATTTGCCGTGCTGTTTACTTTTATTGGCGCTCAGTTTATCGGCATGGGATTACTCGGTGAATATATCGGCAGGATCTACACCGATGTCCGCGCCCGCCCCCGCTATTTTGTTCAGCAAGTTATCCGTCCATCCAGCAAGGAAAATGAATAA", "partial": "0", "query_start": 130217, "query_end": 131191, "orf_dna_sequence": "ATGCTTACTTACCCTCCCGTGAAGAAGGTCTCGGTGGTTATCCCGGTTTATAACGAACAGGATAGCCTGCCGGAACTGCTTCGTCGTACGGATGCCGCCTGCGCCACCCTGGGGCGGCAATATGAAATTCTGTTGATCGACGATGGCAGCAGCGACGATTCCGCGCGCATGCTCACCGAAGCCGCCGAGGCGGAAGGCAGCCACGTCGTCGCCGTGCTGTTAAACCGTAACTACGGCCAGCACTCGGCGATCATGGCCGGCTTCAGCCATGTAACCGGCGATCTGATTATTACCCTCGACGCCGACCTGCAAAACCCGCCGGAGGAGATCCCGCGGCTGGTGGCGAAGGCTGATGAAGGTTACGACGTGGTGGGCACCGTCCGCCAGAACCGTCAGGACAGCATCTTCCGTAAAACCGCGTCGAAGATGATCAACCGCCTGATCCAGCGCACCACCGGCAAAGCGATGGGCGACTACGGCTGCATGCTGCGCGCTTACCGCCGCCATATCATCGACGCCATGCTCAACTGCCATGAGCGCAGCACCTTTATCCCGATCCTGGCGAATACCTTCGCCCGGCGCGCGGTGGAGATCCCGGTGATGCACGCCGAGCGCGAATTCGGCGACTCCAAATACAGCTTTATGCGCCTGATCAACCTGATGTACGACCTGGTGACCTGTCTGACCACCACGCCGCTGCGTCTGCTCAGCATTTTCGGCAGCGTGATTGCCCTGCTGGGCTTCGCCTTCGGCCTGCTGCTGGTGGTGCTGCGTCTGGCCTTTGGCCCGCAGTGGGCGGCGGAAGGGGTGTTTATGCTCTTCGCCGTGCTGTTCATGTTCATCGGCGCCCAGTTTGTCGGTATGGGCCTGCTCGGGGAGTATATCGGCCGCATCTATAACGACGTGCGCGCCCGCCCCCGCTACTTTATTCAACGTGTTGTTCGCCAGCCGGAAACGGCATCTAAAGAGGAAGATCGTTCATGA", "orf_prot_sequence": "MLTYPPVKKVSVVIPVYNEQDSLPELLRRTDAACATLGRQYEILLIDDGSSDDSARMLTEAAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSIFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHERSTFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSIFGSVIALLGFAFGLLLVVLRLAFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYNDVRARPRYFIQRVVRQPETASKEEDRS", "perc_identity": 83.69}}, "NODE_11_length_157792_cov_39.2115_112 # 108413 # 108787 # 1 # ID=11_112;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.509": {"gnl|BL_ORD_ID|1815|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 108413, "orf_end": 108787, "orf_from": "NODE_11_length_157792_cov_39.2115_112", "model_name": "marA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1922", "pass_evalue": "n/a", "pass_bitscore": "230", "ARO_accession": "3000263", "ARO_name": "marA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "41445": {"category_aro_accession": "3004281", "category_aro_cvterm_id": "41445", "category_aro_name": "General Bacterial Porin with reduced permeability to beta-lactams", "category_aro_description": "These are GBPs that are associated with decreased susceptibility to beta-lactams either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}, "36383": {"category_aro_accession": "3000244", "category_aro_cvterm_id": "36383", "category_aro_name": "reduced permeability to antibiotic", "category_aro_description": "Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.82183e-86, "bit_score": 243.432, "max_identities": 115, "cvterm_id": "36839", "query": "MSRRNNDAITIHSILSWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKLTEIAQKLKQSNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNVPGESRYLHPLNN", "match": "MSRRN DAITIHSIL WIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRK+TEIAQKLK+SNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYR+TN+ GESR+LHPLN+", "sequence_from_db": "MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNH", "sequence_from_broadstreet": "MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS", "dna_sequence_from_broadstreet": "ATGTCCAGACGCAATACTGACGCTATTACCATTCATAGCATTTTGGACTGGATCGAGGACAACCTGGAATCGCCACTGTCACTGGAGAAAGTGTCAGAGCGTTCGGGTTACTCCAAATGGCACCTGCAACGGATGTTTAAAAAAGAAACCGGTCATTCATTAGGCCAATACATCCGCAGCCGTAAGATGACGGAAATCGCGCAAAAGCTGAAGGAAAGTAACGAGCCGATACTCTATCTGGCAGAACGATATGGCTTCGAGTCGCAACAAACTCTGACCCGAACCTTCAAAAATTACTTTGATGTTCCGCCGCATAAATACCGGATGACCAATATGCAGGGCGAATCGCGCTTTTTACATCCATTAAATCATTACAACAGCTAG", "partial": "0", "query_start": 108413, "query_end": 108784, "orf_dna_sequence": "ATGTCCAGACGTAATAATGACGCCATCACTATCCATAGTATTTTGTCGTGGATCGAGGATAACCTGGAATCGCCCCTGTCGCTGGAAAAAGTGTCTGAGCGCTCCGGTTACTCTAAGTGGCACCTGCAACGTATGTTTAAGAAAGAGACCGGCCATTCCCTCGGCCAGTACATCCGCAGCCGCAAGCTGACGGAGATTGCGCAGAAGCTCAAGCAGAGTAATGAGCCAATCCTGTACCTGGCGGAACGCTATGGTTTCGAGTCGCAGCAGACCCTGACGCGAACGTTCAAGAACTATTTCGATGTTCCGCCCCACAAGTATCGCATAACGAATGTACCTGGCGAATCCCGCTATCTACATCCGCTAAATAACTGA", "orf_prot_sequence": "MSRRNNDAITIHSILSWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKLTEIAQKLKQSNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNVPGESRYLHPLNN", "perc_identity": 92.74}}, "NODE_11_length_157792_cov_39.2115_132 # 128890 # 129750 # 1 # ID=11_132;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.628": {"gnl|BL_ORD_ID|539|hsp_num:0": {"type_match": "Perfect", "model_id": "578", "orf_strand": "+", "orf_start": 128890, "orf_end": 129750, "orf_from": "NODE_11_length_157792_cov_39.2115_132", "model_name": "SHV-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "550", "ARO_accession": "3001070", "ARO_name": "SHV-11", "ARO_category": {"36024": {"category_aro_accession": "3000015", "category_aro_cvterm_id": "36024", "category_aro_name": "SHV beta-lactamase", "category_aro_description": "SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 580.867, "max_identities": 286, "cvterm_id": "35915", "query": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "match": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "sequence_from_db": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "sequence_from_broadstreet": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "dna_sequence_from_broadstreet": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "partial": "0", "query_start": 128890, "query_end": 129747, "orf_dna_sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGTATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "orf_prot_sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "perc_identity": 100.0}}, "NODE_19_length_86672_cov_43.8582_38 # 39587 # 39811 # -1 # ID=19_38;partial=00;start_type=ATG;rbs_motif=AGxAG;rbs_spacer=5-10bp;gc_cont=0.551": {"gnl|BL_ORD_ID|608|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "tet(31)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "640", "ARO_accession": "3000476", "ARO_name": "tet(31)", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.286606, "max_identities": 12, "bit_score": 25.409, "cvterm_id": "40299", "query": "GQLSMKNVFPTLAVLFAIFSLTGCGLKGPL", "match": "G+L M N + T+A+L      TG GL  P+", "sequence_from_db": "GKLIMMNRYITIALLITFLDATGMGLIMPV", "sequence_from_broadstreet": "MIGKLIMMNRYITIALLITFLDATGMGLIMPVLPTLLEEFSVKESIATHYGFILAIYALMQVIFAPILGQLSDKFGRKPVLILSLIGAVCDYTLLSFSSALWMLYLGRMIAGISAATGAVAASMVADHTKKAERTKWFGKLGAAFGAGLIAGPAIGGFIGQYSAHFPFIIAAILNAIALIMVIILFPKEQSRPKEIEQDQSKIHEKTTINAPLIHILKPVLLLLMLFFTVQLIGQIPASTWVLFTEYRFEWNTFNIGLSLAGLGLMHIIFQAFVAGYIASRWKNETVFILGFILDASAFLLLAFISQVWLVIPTLILLAGGGIALPALQGLISIKTADEHQGKIQGIMVSLTNITGIIGPPIFAFSFAKTVTNWDGTLWLIGAVLYSILLGLYFLYQKIRAYKQLKSQTA", "dna_sequence_from_broadstreet": "ATGATAGGGAAGCTTATAATGATGAATCGCTATATCACAATCGCCCTCTTAATTACCTTCCTAGATGCAACAGGAATGGGCTTAATCATGCCTGTATTACCAACACTTTTAGAAGAGTTCTCTGTCAAAGAGTCTATCGCCACTCATTATGGTTTTATCCTCGCAATCTATGCGCTGATGCAAGTTATTTTTGCACCAATATTAGGACAACTCTCGGATAAATTTGGCAGAAAACCGGTCTTGATTCTCTCATTAATAGGCGCTGTTTGTGATTACACCCTACTCTCATTTTCTAGCGCCTTATGGATGCTCTATCTAGGGAGAATGATTGCCGGCATTTCTGCTGCAACAGGAGCCGTAGCAGCATCAATGGTCGCAGATCACACAAAAAAAGCAGAGAGAACTAAATGGTTTGGAAAGTTAGGCGCAGCTTTTGGGGCGGGACTCATTGCCGGACCCGCTATTGGTGGATTTATCGGACAATATTCTGCACATTTCCCCTTTATCATTGCCGCAATTTTAAATGCCATTGCTCTTATCATGGTCATTATCCTCTTCCCTAAAGAGCAATCACGCCCAAAAGAAATCGAGCAAGATCAATCTAAAATTCATGAAAAAACCACCATCAATGCCCCGCTAATTCATATTCTCAAACCCGTTTTGCTACTTCTCATGCTGTTTTTTACAGTACAACTCATCGGACAAATCCCTGCATCAACTTGGGTTCTATTTACTGAGTACCGTTTTGAGTGGAATACCTTTAACATTGGTTTATCCCTTGCAGGGCTAGGGTTAATGCATATTATCTTTCAGGCTTTTGTCGCAGGATATATCGCATCTCGCTGGAAAAATGAAACCGTATTTATTCTCGGATTTATACTAGATGCGAGCGCATTCTTATTACTGGCCTTTATCTCTCAAGTTTGGCTGGTAATTCCTACATTGATCTTATTAGCAGGAGGAGGCATCGCCTTACCGGCATTACAAGGATTAATCTCTATAAAGACAGCAGATGAACATCAAGGAAAGATACAAGGTATCATGGTTAGCCTCACTAATATTACCGGAATAATTGGACCGCCCATTTTTGCATTTTCCTTTGCAAAAACGGTTACAAACTGGGATGGCACACTTTGGCTAATCGGTGCTGTACTCTATAGCATTTTATTAGGTCTCTATTTTCTCTATCAAAAGATACGCGCCTATAAACAACTTAAGTCTCAAACTGCTTAA", "partial": "0", "query_start": 39596, "query_end": 39685, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 40.0}, "gnl|BL_ORD_ID|1111|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "mdsC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "940", "model_id": "1180", "ARO_accession": "3000791", "ARO_name": "mdsC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.591105, "max_identities": 23, "bit_score": 24.6386, "cvterm_id": "35734", "query": "NHGQLSMKNVF------PTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRG", "match": "N G   MK  F       TLA L  + +L GC +  P +  PA  TA     P      S  PD  D G", "sequence_from_db": "NDGNGIMKITFTGYRQTATLATLAFVTTLAGCTM-APKHERPASPTA--MVYPYATSTVSGAPDAADIG", "sequence_from_broadstreet": "MRTALIRMISKHNDGNGIMKITFTGYRQTATLATLAFVTTLAGCTMAPKHERPASPTAMVYPYATSTVSGAPDAADIGWRDFFHDPLLQELIAIALRNNRDLRKAGLNVEAARALYRIQRAEMLPTLGIATAMDASRTPADLSVMDESEINRRYEAAGATTAWELDLWGRVRSLSDQALAAYMALDETYIAARMSLVSEVASAWLTLRADRELLRLTEDTLAAQKSSYTLTTQLARTGNATQLDLRMAEIALRSAEINRAAYTRQLARDRNALELLLGQPLTPELSRRLNEAVTLTEGAIPTTLPGGLPSDLLVRRPDIRAAEYRLRGANARIGAARAAFFPTISLTGSAGTASASLSGLFEPGSGSWRFLPQITLPLFHGGALRADLDRAHVQKQIEIARYENVIQQAFRDVADGLAGQRTLNDQVQSEQRAVEASQIAYELAGLRFQEGVDDYLTLLDTHRMLYGAQQRLVRTRLMQQLNIINLYKALGGGWREYSEKKQG", "dna_sequence_from_broadstreet": "GTGAGAACCGCGTTGATTCGCATGATCAGCAAGCATAATGATGGGAATGGCATAATGAAGATCACTTTTACAGGCTATCGGCAGACCGCCACGCTGGCGACGCTTGCTTTCGTCACCACGCTTGCTGGCTGTACGATGGCGCCGAAGCACGAACGCCCCGCATCGCCGACTGCGATGGTCTATCCCTACGCAACGTCAACCGTTTCTGGCGCGCCGGATGCCGCTGACATTGGCTGGCGTGATTTCTTCCACGATCCGCTTCTACAGGAACTGATTGCGATCGCGTTACGCAATAATCGGGATTTACGCAAGGCAGGGCTCAATGTTGAAGCCGCCCGGGCGTTATACCGCATTCAGCGCGCGGAGATGCTGCCGACGCTCGGCATCGCCACCGCCATGGACGCCAGTCGCACTCCCGCCGATCTCAGCGTCATGGACGAGTCTGAGATTAACCGACGCTACGAGGCGGCTGGGGCGACGACGGCCTGGGAACTGGATCTCTGGGGGCGAGTGCGAAGCCTTAGCGACCAGGCATTAGCCGCCTATATGGCGCTTGATGAGACGTACATTGCGGCGCGAATGAGCCTGGTTTCCGAAGTCGCCAGCGCCTGGCTGACGCTACGGGCTGACCGGGAGCTGCTGCGCTTAACCGAGGATACGCTGGCCGCGCAAAAAAGTTCATACACATTGACGACCCAGCTTGCCCGGACAGGTAACGCCACACAGCTCGATCTGCGTATGGCGGAGATCGCGCTGCGTTCTGCCGAAATCAATCGCGCGGCGTATACGCGACAGTTGGCGCGGGATCGTAACGCGCTGGAATTGCTGTTGGGCCAGCCGCTCACGCCTGAACTGTCGCGTCGACTAAACGAAGCGGTCACGCTTACAGAAGGCGCGATCCCGACCACACTGCCAGGCGGATTACCGTCAGATCTGCTGGTACGCCGCCCGGATATTCGCGCCGCCGAGTACAGGCTGCGCGGCGCAAACGCCCGGATAGGCGCAGCGCGCGCCGCCTTCTTCCCGACCATCAGCCTGACAGGCTCGGCGGGAACGGCCAGCGCGTCTCTTAGCGGACTCTTTGAACCGGGATCGGGAAGCTGGCGTTTTCTACCGCAAATCACCTTGCCTCTCTTTCACGGCGGCGCATTACGCGCTGACCTGGATAGGGCGCATGTCCAAAAACAGATTGAAATCGCCAGGTATGAAAACGTTATTCAGCAAGCCTTTCGCGACGTGGCGGATGGTCTGGCGGGACAGCGTACGCTGAATGACCAGGTGCAATCAGAACAACGCGCGGTTGAAGCCAGTCAAATCGCCTATGAGCTGGCCGGACTCCGTTTTCAGGAAGGCGTCGATGACTACCTTACGCTGCTTGATACCCATCGTATGCTTTATGGCGCACAACAGCGCCTGGTACGCACACGTCTCATGCAACAGTTAAATATCATTAACCTGTATAAAGCATTAGGCGGCGGTTGGCGGGAATACAGTGAGAAAAAGCAAGGTTAG", "partial": "0", "query_start": 39590, "query_end": 39778, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 33.33}, "gnl|BL_ORD_ID|1382|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "facT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1050", "model_id": "1469", "ARO_accession": "3001313", "ARO_name": "facT", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37619": {"category_aro_accession": "3001220", "category_aro_cvterm_id": "37619", "category_aro_name": "factumycin", "category_aro_description": "Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum,  antibacterial properties, especially targeting various Acinetobacter baumanii strains.", "category_aro_class_name": "Antibiotic"}, "37618": {"category_aro_accession": "3001219", "category_aro_cvterm_id": "37618", "category_aro_name": "elfamycin antibiotic", "category_aro_description": "Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.753437, "max_identities": 11, "bit_score": 24.2534, "cvterm_id": "37730", "query": "GCGLKGPLYFPPADKTAPPPTKPVNPGIQSATP", "match": "G  + G L+F      A P  + V P +QS +P", "sequence_from_db": "GVAVIGSLFFAALAGNAGPQAERVAPTVQSVSP", "sequence_from_broadstreet": "MNKAGQAEKPAAAGPPATPETPEPDPKRWLALTVLLVATFMDLLDANIITVAIPSIQRDLGASTFAIQAMTAGYTLSFAVLLITGGRLGDIFGRKRMFLVGVGGFVLASAMCAAAPSTDLLVVARALQGLTAAVMVPQVLALIHVSFAPQEIGRVVSLYASMVGLAIVSGPLIGGALISWNPLDLGWRSIFVVNLPVGVLALVGAAKWMRESSSPHAKRLDIAGMLLIVLGLLLLMVPLTLGRELDWPVWSIVSLVAAAPVLVLFVVYERHKTAKDGSPLVTLSLFKVRAFGAGIGVQLLFSAIPAGFFLSWTLYLQAGLGWSALHTGLTAIPFSLCVPIVGGLAVRRLSPLYGRYCLLAGAVLMLAGILSYAWAADRFGTDITSWHAIPSMLLIGSGMGMLMPPLTALVLREVQPQEAGAASGIINATGQLGAALGVAVIGSLFFAALAGNAGPQAERVAPTVQSVSPRQASDLRDCATEALGQDDLAKVPDICSTLVQGADDGTRDTINGALGEIRAKTFVSTYSETLYWAAGGLVPVTALVLLLPHHRVRREEPAQ", "dna_sequence_from_broadstreet": "ATGAACAAGGCAGGGCAGGCAGAAAAGCCGGCGGCAGCCGGCCCACCTGCCACTCCCGAGACGCCCGAGCCCGACCCGAAGCGGTGGCTCGCGCTGACAGTCCTGCTGGTCGCCACCTTCATGGACCTGCTCGACGCGAACATCATCACCGTGGCCATCCCGAGCATCCAACGCGACCTCGGCGCCTCGACCTTCGCCATCCAGGCGATGACGGCCGGCTACACCCTGAGCTTCGCGGTCCTGCTGATCACCGGCGGCCGGCTCGGCGACATCTTCGGCCGCAAGCGCATGTTCCTCGTCGGCGTCGGCGGCTTCGTCCTCGCGTCCGCGATGTGCGCCGCCGCGCCGAGCACCGACTTACTCGTCGTCGCCCGCGCGCTCCAGGGCCTCACCGCCGCCGTCATGGTGCCCCAGGTGCTCGCGCTCATCCACGTCTCCTTCGCGCCCCAGGAGATCGGCCGCGTCGTCAGCCTGTACGCGAGCATGGTCGGTCTGGCCATCGTCTCCGGGCCCCTCATCGGCGGTGCGCTGATCAGCTGGAACCCGCTGGACCTCGGCTGGCGCAGCATCTTCGTGGTGAACCTGCCGGTCGGCGTGCTCGCCCTGGTCGGCGCCGCGAAGTGGATGCGGGAGTCGAGCTCCCCCCATGCGAAGCGCCTGGACATCGCCGGCATGCTGCTGATCGTGCTCGGCCTGCTGCTGCTCATGGTGCCGCTGACCCTCGGCCGCGAGCTCGACTGGCCGGTGTGGAGCATCGTCTCGCTCGTCGCCGCCGCCCCCGTCCTCGTGCTGTTCGTCGTCTACGAGCGCCACAAGACCGCCAAGGACGGCTCGCCCCTGGTGACGCTGTCCCTGTTCAAGGTCCGCGCGTTCGGCGCCGGCATCGGCGTCCAGCTCCTCTTCAGCGCCATCCCCGCGGGCTTCTTCCTCAGCTGGACCCTCTACCTCCAGGCCGGCCTCGGCTGGTCGGCCCTGCACACGGGCCTGACCGCCATCCCGTTCTCCCTGTGCGTCCCGATCGTCGGCGGTCTCGCCGTCCGCAGGCTCTCGCCGCTCTACGGCCGCTACTGCCTGCTCGCCGGTGCCGTCCTGATGCTCGCGGGCATCCTCTCCTACGCCTGGGCGGCCGACCGCTTCGGCACGGACATCACCTCCTGGCACGCGATCCCGTCCATGCTCCTGATCGGCTCCGGCATGGGCATGCTGATGCCCCCGCTGACGGCGCTGGTGCTCAGGGAGGTCCAGCCGCAGGAGGCCGGCGCCGCCTCCGGCATCATCAACGCCACCGGCCAGCTCGGTGCCGCGCTCGGCGTGGCGGTCATCGGCAGCCTCTTCTTCGCGGCCCTCGCCGGCAACGCCGGGCCGCAGGCCGAACGCGTCGCCCCCACCGTGCAGTCGGTCTCACCCCGGCAGGCCTCCGACCTCCGGGACTGCGCGACCGAGGCGCTGGGCCAGGACGACCTGGCCAAGGTCCCGGACATCTGCTCCACCCTGGTGCAGGGCGCCGACGACGGCACCCGGGATACGATCAATGGCGCGCTCGGCGAGATCCGCGCGAAGACGTTCGTGTCCACCTACAGCGAGACGCTGTACTGGGCGGCCGGTGGCCTCGTCCCGGTCACCGCCCTCGTCCTGCTCCTGCCGCACCACCGCGTCCGGCGGGAGGAACCGGCCCAGTGA", "partial": "0", "query_start": 39662, "query_end": 39760, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 33.33}, "gnl|BL_ORD_ID|451|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45385, "max_identities": 16, "bit_score": 23.483, "cvterm_id": "36804", "query": "SMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGI", "match": "+M+ + P  A+L AI +L+GCG             APPP +    GI", "sequence_from_db": "AMRVLVP--ALLVAISALSGCG----------KSEAPPPAQTPEVGI", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 39605, "query_end": 39745, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.04}, "gnl|BL_ORD_ID|450|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45385, "max_identities": 16, "bit_score": 23.483, "cvterm_id": "36804", "query": "SMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGI", "match": "+M+ + P  A+L AI +L+GCG             APPP +    GI", "sequence_from_db": "AMRVLVP--ALLVAISALSGCG----------KSEAPPPAQTPEVGI", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 39605, "query_end": 39745, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.04}, "gnl|BL_ORD_ID|2351|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "FRI-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "3594", "ARO_accession": "3004799", "ARO_name": "FRI-3", "ARO_category": {"42915": {"category_aro_accession": "3004796", "category_aro_cvterm_id": "42915", "category_aro_name": "FRI beta-lactamase", "category_aro_description": "FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.97764, "max_identities": 9, "bit_score": 21.9422, "cvterm_id": "36884", "query": "NPGIQSATPDRNDRGDTGG", "match": "N  I++A PD+ D GD  G", "sequence_from_db": "NARIRAAVPDKWDVGDKTG", "sequence_from_broadstreet": "MFFLKKAQVHLFFFLCLPLNSFASQESNSIEQMRELEAAFGGRIGVYILNTKNGKEFSYRQDERFPLCSSFKAFLAASVLKKTQDKSVSLDDMMEYSGRVMEKHSPVSEKYRKTGASVRTLAKAAIQYSDNGASNLLMERYIGGPEGLTAFMRSTGDTDFRLDRWELELNSAIPGDERDTSTPKAVAMSLKNIAFGSVLDAKNKSLLQEWLKGNTTGNARIRAAVPDKWDVGDKTGTCGFYGTANDVAILWPDANSPAVMAVYTTRPNQNDKHDEAVIKNSAKIAINAVYGSYK", "dna_sequence_from_broadstreet": "ATGTTTTTTTTAAAAAAAGCGCAAGTACATTTATTTTTTTTTCTCTGTCTTCCATTGAACTCATTCGCCTCTCAGGAAAGTAATAGTATTGAGCAAATGAGGGAATTGGAAGCTGCTTTTGGGGGGCGGATAGGTGTTTATATTTTAAACACAAAGAATGGGAAAGAATTTTCCTACAGACAAGATGAGAGATTTCCTTTATGTAGTTCATTTAAGGCATTCCTCGCTGCATCCGTATTAAAAAAAACTCAGGATAAATCTGTTTCTCTTGATGATATGATGGAATATTCTGGACGTGTTATGGAAAAGCATTCTCCTGTGTCAGAAAAATACCGCAAAACAGGAGCAAGCGTGCGGACTTTGGCGAAGGCAGCAATTCAGTACAGTGACAATGGAGCTTCTAATCTATTAATGGAAAGATACATAGGAGGTCCTGAGGGTTTGACTGCATTTATGCGGTCAACGGGAGACACTGACTTCAGGCTTGATCGTTGGGAATTAGAATTAAACTCAGCTATTCCAGGCGATGAACGAGATACTTCAACTCCAAAAGCAGTGGCAATGAGCCTTAAAAATATTGCTTTTGGTTCAGTACTCGATGCTAAAAATAAATCATTGCTGCAGGAATGGCTTAAAGGCAACACTACTGGTAATGCGCGAATTAGAGCTGCGGTTCCAGATAAGTGGGATGTTGGCGATAAAACAGGCACCTGTGGTTTTTATGGTACAGCCAATGATGTTGCTATTTTATGGCCAGACGCTAATTCACCTGCAGTTATGGCTGTCTACACAACACGTCCTAATCAAAACGACAAACATGACGAAGCAGTAATTAAAAATTCTGCAAAAATAGCTATAAATGCAGTGTATGGAAGTTATAAATAA", "partial": "0", "query_start": 39734, "query_end": 39790, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 47.37}, "gnl|BL_ORD_ID|2592|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "CBP-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "3567", "ARO_accession": "3004764", "ARO_name": "CBP-1", "ARO_category": {"42877": {"category_aro_accession": "3004763", "category_aro_cvterm_id": "42877", "category_aro_name": "CBP beta-lactamase", "category_aro_description": "CBP is a class A beta-lactamase family found in C. botulinum.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.59226, "max_identities": 8, "bit_score": 21.557, "cvterm_id": "41649", "query": "IFSLTGCG", "match": "IFSLTGCG", "sequence_from_db": "IFSLTGCG", "sequence_from_broadstreet": "MKKIVNSKLKVNKFKMCIFISILIFSLTGCGNVENKTSENTKPEIQYNSAFSKIESDYGVKLGVYAFDTETNKEVTYNADKRFAYCSTFKSLISGAILQKYSSDQLKQVIKYSPKDVLSYAPVTKNHVDKGMTIEELCDAAVRFSDNTAANLLINLIGGPNGFKSALNQLGDTVTEPARIEPELNVATPGDNRDTSTPRQLSIDLKEYTTGNILSDDKKKILINWMSGNATGDKLIRAGAPKDWMVSDKSGTGSYGTRNDIAIVIPPNKKPIFIAILSSKNDKDAKYDDKTISEASKIVFDYFINTRK", "dna_sequence_from_broadstreet": "ATGAAAAAAATAGTAAACTCAAAATTAAAGGTAAATAAATTTAAAATGTGTATATTTATATCAATTCTTATATTTTCTCTTACTGGATGTGGAAATGTAGAAAATAAAACTTCTGAAAATACAAAACCTGAGATACAATATAATTCAGCATTTTCAAAAATTGAAAGTGATTATGGTGTTAAACTTGGTGTATATGCTTTTGATACAGAAACAAATAAAGAAGTTACATATAATGCTGATAAGAGATTCGCTTACTGTTCTACCTTTAAATCTTTAATATCCGGTGCGATTTTACAAAAATATTCATCAGACCAACTTAAACAAGTAATTAAATATAGCCCAAAAGATGTACTGTCTTATGCACCAGTTACAAAAAATCATGTTGATAAAGGTATGACTATTGAAGAACTTTGCGATGCGGCAGTACGCTTTAGTGATAATACAGCTGCAAATCTTTTGATTAATCTTATAGGTGGACCTAATGGTTTTAAATCAGCACTTAATCAATTAGGTGACACAGTTACAGAACCTGCACGTATCGAACCAGAACTAAATGTTGCTACACCTGGAGATAATAGGGATACTAGTACTCCAAGACAATTATCAATTGATTTAAAAGAATACACAACTGGAAATATATTATCAGATGATAAGAAAAAAATTCTTATTAATTGGATGTCAGGAAATGCAACAGGTGATAAGCTAATTCGTGCAGGAGCACCAAAAGACTGGATGGTTTCTGATAAAAGTGGAACTGGTTCTTACGGAACAAGAAATGATATTGCAATAGTAATACCACCAAATAAAAAGCCTATATTTATTGCAATATTATCAAGTAAAAACGATAAAGATGCTAAATATGATGACAAAACAATTTCTGAGGCTTCTAAAATTGTATTTGATTATTTTATTAACACCAGGAAATAG", "partial": "0", "query_start": 39647, "query_end": 39670, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2555|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "ACI-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2874", "ARO_accession": "3004359", "ARO_name": "ACI-1", "ARO_category": {"41530": {"category_aro_accession": "3004358", "category_aro_cvterm_id": "41530", "category_aro_name": "ACI beta-lactamase", "category_aro_description": "A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "36989": {"category_aro_accession": "3000645", "category_aro_cvterm_id": "36989", "category_aro_name": "cefotaxime", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.58332, "max_identities": 8, "bit_score": 21.1718, "cvterm_id": "41532", "query": "PPPTKPVNPGIQSATPDRNDRGD", "match": "PP  KP+   I S   ++N + D", "sequence_from_db": "PPNRKPIVMAIMSRRTEKNAKSD", "sequence_from_broadstreet": "MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDTRFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSASLRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQMVKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDIAVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF", "dna_sequence_from_broadstreet": "ATGAAGAAATTTTGTTTTTTGTTTTTGATAATCTGTGGCTTGATGGTTTTCTGCCTTCAGGATTGTCAAGCGCGGCAGAAATTAAATCTTGCTGATCTGGAAAATAAATATAACGCCGTGATTGGTGTTTACGCCGTTGACATGGAGAATGGAAAAAAAATTTGCTACAAACCTGATACGCGTTTTTCCTACTGCTCGACACACAAAGTTTTTACGGCTGCAGAATTGCTAAGACAAAAAAATACCTCCGATTTGAATGAAATTCGTAAGTTTTCGGCGGAAGATATTTTGTCCTACGCGCCAATCACCAAAGACCATGTTGCTGATGGCATGACGCTGGCGGAAATTTGTTCGGCATCGCTCAGGTGGAGTGACAACACGGCGGCAAATTTAATTTTGCAGGAGATCGGCGGCGTGGAAAATTTCAAGGTGGCACTTAAAAATATTGGCGACAAAACTACCAAACCTGCGCGAAATGAACCTGAACTTAATCTTTTCAATCCAAAAGATAATCGTGATACTAGCACGCCGAGACAGATGGTAAAAAATTTGCAAGTCTATATATTCGGCGATATTTTGAGCGACGACAAGAAAAAACTGCTGATTGATTGGATGAGCGACAATTCCATAACCGACACGCTTATCAAGGCAGAAACTCCGCAAGGTTGGAAAGTTATCGACAAGAGCGGTTCAGGCGATTATGGGGCGCGGAATGATATTGCCGTGATTTATCCGCCCAATCGCAAACCCATTGTCATGGCGATAATGTCGCGCCGCACGGAAAAAAATGCAAAATCTGACGACGCTATGATTGCGGAGGCGGCAAAACGAATTTTTGATAATTTAGTATTTTAA", "partial": "0", "query_start": 39713, "query_end": 39781, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.78}}, "NODE_21_length_66123_cov_41.3566_52 # 60858 # 62090 # 1 # ID=21_52;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.603": {"gnl|BL_ORD_ID|2494|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 60858, "orf_end": 62090, "orf_from": "NODE_21_length_66123_cov_41.3566_52", "model_name": "Escherichia coli mdfA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "37", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3001328", "ARO_name": "Escherichia coli mdfA", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "40514": {"category_aro_accession": "3003823", "category_aro_cvterm_id": "40514", "category_aro_name": "benzalkonium chloride", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent.", "category_aro_class_name": "Drug Class"}, "40518": {"category_aro_accession": "3003827", "category_aro_cvterm_id": "40518", "category_aro_name": "rhodamine", "category_aro_description": "Rhodamine is a flurone dye that is often used as a tracer due to determine the rate and direction of flow and transport. It permeates the cell membrane of gram negative organisms E. coli and P. aeruginosa.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 706.057, "max_identities": 351, "cvterm_id": "35914", "query": "MQNYSLSGRRLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVQEFQVGNEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFIVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEMMFVLFAVLAAISFFGLQRAMPETATRLGEKLSVKELGRDYRLVLKNLRFVAGALATGFVSLPLLAWIAQSPVIIISGEQATSYEYGMLQVPIFGALIAGNLVLARLTARRTVRSLIIMGGWPIMFGLILSAAATVVSSHAYLWMTAGLSFYAFGIGLANAGLVRLTLFASEMSKGTVSAAMGMLQMLIFTVGIELSKHAYELGGNGLFSLFNLLGGVLWLGLMIYFLKDKSVGNSQQG", "match": "MQN   SG RLGRQALLFPLCLVLYEFSTYIGNDM QPGML  V+++Q G EWVPTSM AYLAGGMF+QWLLGPLSDRIGRRPVML GVVWFIVTCLA LLAQ IEQFTLLRFL GISLCFIGAVGY AIQESFEEAVCIKITALMANVALIAPLLGPLVGA+W+HVLPWE MFVLFA LAAISFFGLQRAMPETATR+GEKLS+KELGRDY+LVLKN RFVAGALA GF+SLPLLAWIAQSP+III+GEQ +SYEYG+LQVPIFGALIAGNL+LARLT+RRTVRSLIIMGGWPIM GL+++AAATV+SSHAYLWMTAGLS YAFGIGLANAGLVRLTLFAS MSKGTVSAAMGMLQMLIFTVGIE+SKHA+  GGNGLF+LFNL+ G+L L LM+ FLKDK +GNS +G", "sequence_from_db": "MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMRQPGMLENVEQYQAGIEWVPTSMNAYLAGGMFIQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLHGISLCFIGAVGYDAIQESFEEAVCIKITALMANVALIAPLLGPLVGASWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFLSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASVMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILLLSLMVIFLKDKQMGNSHEG", "sequence_from_broadstreet": "MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMRQPGMLENVEQYQAGIEWVPTSMNAYLAGGMFIQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLHGISLCFIGAVGYDAIQESFEEAVCIKITALMANVALIAPLLGPLVGASWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFLSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASVMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILLLSLMVIFLKDKQMGNSHEG", "dna_sequence_from_broadstreet": "ATGCAAAATAAATTAGCTTCCGGTGCCAGGCTTGGACGTCAGGCGTTACTTTTTCCTCTCTGTCTGGTGCTTTACGAATTTTCAACCTATATCGGCAACGATATGAGGCAACCCGGTATGTTGGAAAATGTGGAACAATATCAGGCGGGCATTGAGTGGGTTCCTACTTCGATGAACGCGTATCTGGCGGGCGGGATGTTTATACAATGGCTGCTGGGGCCGCTGTCGGATCGTATTGGTCGTCGTCCGGTGATGCTGGCGGGAGTGGTGTGGTTTATCGTCACATGTCTGGCAATATTGCTGGCGCAAAACATTGAACAATTCACCCTGTTGCGCTTCTTGCACGGCATAAGCCTCTGTTTCATTGGCGCTGTGGGATACGACGCAATTCAGGAATCCTTCGAAGAGGCGGTTTGTATCAAGATCACCGCGCTGATGGCGAACGTGGCGCTGATTGCTCCGCTACTTGGTCCGCTGGTGGGCGCGTCGTGGATCCATGTGCTGCCCTGGGAGGGGATGTTTGTTTTGTTTGCCGCATTGGCAGCGATCTCCTTTTTCGGTCTGCAACGGGCCATGCCTGAAACCGCCACGCGTATAGGCGAGAAACTGTCACTGAAAGAACTCGGTCGTGACTATAAGCTGGTGCTGAAGAACGGCCGCTTTGTGGCGGGGGCGCTGGCGCTGGGATTCCTTAGTCTGCCGTTGCTGGCGTGGATCGCCCAGTCGCCGATTATCATCATTACCGGCGAGCAGTTGAGCAGCTATGAATATGGCTTGCTGCAAGTGCCTATTTTCGGGGCGTTAATTGCGGGTAACTTGCTGTTAGCGCGTCTGACCTCGCGCCGCACCGTACGTTCGCTGATTATTATGGGCGGCTGGCCGATTATGATTGGTCTATTGGTCGCTGCTGCGGCAACGGTTATCTCATCGCACGCGTATTTATGGATGACTGCCGGGTTAAGTATTTATGCTTTCGGTATTGGTCTGGCGAATGCGGGACTGGTGCGATTAACCCTGTTTGCCAGCGTTATGAGTAAAGGTACGGTTTCTGCCGCGATGGGAATGCTGCAAATGCTGATCTTTACCGTTGGTATTGAAATCAGCAAACATGCCTGGCTGAACGGGGGCAACGGACTGTTTAATCTCTTCAACCTTGTCAACGGAATTTTGTTGCTGTCGCTGATGGTTATCTTTTTAAAAGATAAACAGATGGGAAATTCTCACGAAGGGTAA", "partial": "0", "query_start": 60858, "query_end": 62087, "orf_dna_sequence": "ATGCAAAATTATTCGCTTTCAGGCCGCCGCCTCGGAAGGCAGGCGCTGTTGTTCCCGTTATGTCTGGTGCTGTACGAGTTTTCCACTTATATCGGCAACGATATGATTCAGCCGGGCATGTTAGCCGTGGTGCAGGAATTTCAGGTGGGCAACGAATGGGTACCTACTTCAATGACTGCCTATCTGGCAGGCGGCATGTTTTTACAGTGGCTGCTGGGGCCGCTGTCGGATCGTATTGGCCGCCGTCCGGTGATGTTGACCGGCGTAGTATGGTTTATCGTCACCTGCCTGGCGACGCTGCTGGCGCAGACCATTGAGCAGTTTACCCTGCTGCGCTTCCTGCAGGGGATCAGCCTGTGCTTTATCGGCGCGGTGGGCTATGCGGCGATACAGGAGTCCTTTGAGGAGGCGGTGTGTATCAAAATCACCGCCCTGATGGCTAACGTGGCGCTGATTGCCCCGCTGCTGGGGCCGCTGGTGGGCGCCGCCTGGGTGCATGTCCTGCCGTGGGAGATGATGTTTGTCCTGTTCGCCGTGCTGGCGGCCATCTCGTTCTTCGGCCTGCAGCGGGCGATGCCGGAGACCGCGACGCGGCTGGGCGAAAAGCTGTCGGTGAAAGAGCTGGGCCGCGACTATCGGCTGGTGCTGAAGAACCTGCGCTTCGTCGCCGGCGCGCTGGCCACTGGCTTTGTCAGCCTGCCGCTGCTGGCGTGGATTGCCCAGTCGCCGGTGATTATTATCAGCGGCGAACAGGCCACCAGCTATGAGTACGGCATGCTGCAGGTGCCGATTTTCGGGGCGCTGATTGCCGGCAACCTGGTGCTGGCGCGCCTGACTGCGCGTCGGACCGTGCGCTCGCTGATTATCATGGGCGGTTGGCCGATCATGTTTGGCCTGATCCTCTCTGCGGCGGCGACCGTGGTCTCTTCCCACGCTTATCTGTGGATGACGGCCGGTCTGAGCTTCTACGCCTTCGGGATTGGCCTCGCGAACGCCGGCCTGGTGCGTTTAACCCTGTTCGCCAGCGAGATGAGTAAAGGCACGGTCTCGGCGGCGATGGGAATGCTGCAGATGCTGATCTTCACCGTCGGCATCGAGCTCAGCAAACATGCTTACGAGCTGGGCGGCAACGGGCTGTTCAGCCTGTTTAACCTGCTGGGTGGGGTACTATGGCTGGGGCTGATGATTTACTTTCTGAAAGATAAAAGCGTCGGCAATTCGCAGCAGGGGTAG", "orf_prot_sequence": "MQNYSLSGRRLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVQEFQVGNEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFIVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEMMFVLFAVLAAISFFGLQRAMPETATRLGEKLSVKELGRDYRLVLKNLRFVAGALATGFVSLPLLAWIAQSPVIIISGEQATSYEYGMLQVPIFGALIAGNLVLARLTARRTVRSLIIMGGWPIMFGLILSAAATVVSSHAYLWMTAGLSFYAFGIGLANAGLVRLTLFASEMSKGTVSAAMGMLQMLIFTVGIELSKHAYELGGNGLFSLFNLLGGVLWLGLMIYFLKDKSVGNSQQG", "perc_identity": 85.61}}, "NODE_27_length_37761_cov_37.6839_21 # 25311 # 25673 # 1 # ID=27_21;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.471": {"gnl|BL_ORD_ID|2771|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 25311, "orf_end": 25673, "orf_from": "NODE_27_length_37761_cov_37.6839_21", "model_name": "Klebsiella pneumoniae KpnE", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3283", "pass_evalue": "n/a", "pass_bitscore": "150", "ARO_accession": "3004580", "ARO_name": "Klebsiella pneumoniae KpnE", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.37865e-78, "bit_score": 223.402, "max_identities": 119, "cvterm_id": "42598", "query": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSKQEVAHAAV", "match": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASS+QEVAHAAV", "sequence_from_db": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV", "sequence_from_broadstreet": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV", "dna_sequence_from_broadstreet": "ATGTTTTATTGGATTTTATTAGCTTTAGCAATTATTGCTGAAATTACCGGCACCTTGTCTATGAAATGGGCAAGCGTGAGCGGCGGGCACACCGGCTTTATTTTAATGCTGGCCATGATTGCCCTGTCATATATTTTTCTTGCCTTTGCGGTTAAAAAGATTGCCCTCGGTGTGGCCTATGCGTTGTGGGAAGGGATCGGTATTTTACTGATTACCCTGTTCAGCGTGCTGCTGTTTGATGAGAGTCTGTCCCTGCTGAAAATAGCCGGCTTGACCACCCTGGTGATAGGGATCGTCTTAATTAAGTCCGGCACCCAGAAAAAAGCGTCTTCACAGCAGGAGGTGGCCCATGCAGCAGTTTGA", "partial": "0", "query_start": 25311, "query_end": 25670, "orf_dna_sequence": "ATGTTTTATTGGATTTTATTAGCTTTAGCAATTATTGCTGAAATTACCGGCACCTTGTCTATGAAATGGGCAAGCGTGAGCGGCGGGCACACCGGCTTTATTTTAATGCTGGCCATGATTGCCCTGTCATATATTTTTCTTGCCTTTGCGGTTAAAAAGATTGCCCTCGGTGTGGCCTATGCGTTGTGGGAAGGGATCGGTATTTTACTGATTACCCTGTTCAGCGTGCTGCTGTTTGATGAGAGTCTGTCCCTGCTGAAAATAGCCGGCTTGACCACCCTGGTGATAGGGATCGTCTTAATTAAGTCCGGCACCCAGAAAAAAGCGTCTTCCAAGCAGGAGGTGGCCCATGCAGCAGTTTGA", "orf_prot_sequence": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSKQEVAHAAV", "perc_identity": 99.17}}, "NODE_27_length_37761_cov_37.6839_22 # 25660 # 25989 # 1 # ID=27_22;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.588": {"gnl|BL_ORD_ID|2774|hsp_num:0": {"type_match": "Perfect", "model_id": "3286", "orf_strand": "+", "orf_start": 25660, "orf_end": 25989, "orf_from": "NODE_27_length_37761_cov_37.6839_22", "model_name": "Klebsiella pneumoniae KpnF", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "150", "ARO_accession": "3004583", "ARO_name": "Klebsiella pneumoniae KpnF", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.08351e-72, "bit_score": 206.453, "max_identities": 109, "cvterm_id": "42598", "query": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "match": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "sequence_from_db": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "sequence_from_broadstreet": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "dna_sequence_from_broadstreet": "ATGCAGCAGTTTGAGTGGATCCACGCCGCCTGGCTGGCAATCGCCATTGTGCTGGAAATTATTGCCAACGTCTTTTTGAAGTTTTCCGACGGCTTCCGCCGCAAGATCTACGGCATCCTGTCCCTGGCGGCAGTATTGGGCGCGTTCAGCGCCCTGTCGCAGGCGGTTAAAGGGATCGATCTCTCGGTCGCCTATGCGCTGTGGGGCGGCTTCGGTATCGCGGCGACCATCGCCGCCGGCTGGGTGCTGTTTGGTCAGCGTCTGAATAACAAAGGCTGGGCGGGGGTTATCCTGCTGGTAGCCGGCATGGTGTTAATTAAACTCGCCTGA", "partial": "0", "query_start": 25660, "query_end": 25986, "orf_dna_sequence": "ATGCAGCAGTTTGAGTGGATCCACGCCGCCTGGCTGGCAATCGCCATTGTGCTGGAAATTATTGCCAACGTCTTTTTGAAGTTTTCCGACGGCTTCCGCCGCAAGATCTACGGCATCCTGTCCCTGGCGGCAGTATTGGGCGCGTTCAGCGCCCTGTCGCAGGCGGTTAAAGGGATCGATCTCTCGGTCGCCTATGCGCTGTGGGGCGGCTTCGGTATCGCGGCGACCATCGCCGCCGGCTGGGTGCTGTTTGGTCAGCGTCTGAATAACAAAGGCTGGGCGGGGGTTATCCTGCTGGTAGCCGGCATGGTGTTAATTAAACTCGCCTGA", "orf_prot_sequence": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "perc_identity": 100.0}}, "NODE_39_length_11164_cov_23.0187_6 # 4569 # 5429 # 1 # ID=39_6;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.598": {"gnl|BL_ORD_ID|2170|hsp_num:0": {"type_match": "Perfect", "model_id": "3322", "orf_strand": "+", "orf_start": 4569, "orf_end": 5429, "orf_from": "NODE_39_length_11164_cov_23.0187_6", "model_name": "AAC(3)-IId", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "570", "ARO_accession": "3004623", "ARO_name": "AAC(3)-IId", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 586.645, "max_identities": 286, "cvterm_id": "35914", "query": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "match": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "sequence_from_db": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "sequence_from_broadstreet": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "dna_sequence_from_broadstreet": "ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCCGGTTAG", "partial": "0", "query_start": 4569, "query_end": 5426, "orf_dna_sequence": "ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCAGGTTAG", "orf_prot_sequence": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "perc_identity": 100.0}}, "NODE_40_length_7360_cov_24.8738_6 # 6358 # 7203 # -1 # ID=40_6;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.410": {"gnl|BL_ORD_ID|1448|hsp_num:0": {"type_match": "Perfect", "model_id": "1540", "orf_strand": "-", "orf_start": 6358, "orf_end": 7203, "orf_from": "NODE_40_length_7360_cov_24.8738_6", "model_name": "rmtC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000861", "ARO_name": "rmtC", "ARO_category": {"41435": {"category_aro_accession": "3004271", "category_aro_cvterm_id": "41435", "category_aro_name": "16S rRNA methyltransferase (G1405)", "category_aro_description": "Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site.", "category_aro_class_name": "AMR Gene Family"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36997": {"category_aro_accession": "3000653", "category_aro_cvterm_id": "36997", "category_aro_name": "G418", "category_aro_description": "A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3').", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 578.941, "max_identities": 281, "cvterm_id": "36752", "query": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "match": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "sequence_from_db": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "sequence_from_broadstreet": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "dna_sequence_from_broadstreet": "ATGAAAACCAACGATAATTATATCGAAGAAGTAACAGCCAAAGTACTCACAAGTGGTAAATACTCCACACTTTATCCACCAACTGTACGACGTGTAACTGAGAGGCTTTTCGATCGATACCCTCCCAAGCAGCTAGAGAAGGAGGTTCGCAAGAAATTGCATCAAGCATATGGTGCTTATATTGGTGGGATCGATGGGAAAAGGTTGGAGAAGAAGATTGAGAAGATAATTCATGAGATACCAAATCCAACTACGGATGAAGCAACTCGTACGGAGTGGGAAAAAGAGATCTGCCTGAAAATATTGAACTTGCACACTTCAACAAATGAGCGAACGGTGGCTTACGATGAGCTTTACCAAAAGATCTTTGAGGTAACAGGGGTTCCAACAAGTATCACCGATGCAGGTTGCGCTTTGAATCCATTTTCTTTTCCATTCTTTACGGAGGCTGGCATGCTTGGGCAATACATAGGTTTCGATCTTGATAAAGGTATGATCGAAGCGATCGAACACTCGTTGAGAACGCTTAACGCCCCAGAGGGTATTGTTGTCAAACAGGGAGATATATTATCCGATCCGTCAGGCGAGAGTGATCTTCTACTTATGTTCAAGCTATATACTCTACTCGATCGGCAGGAAGAGGCCTCTGGTTTGAAAATTCTTCAAGAGTGGAAATACAAAAATGCTGTGATCTCTTTTCCTATTAAAACTATAAGTGGGAGAGATGTTGGGATGGAAGAGAATTACACTGTTAAGTTCGAGAATGATCTTGTTGGGTCAGATCTGAGAATCATGCAAAAATTGAAATTAGGAAACGAGATGTATTTTATCGTATCGAGATTGTAA", "partial": "0", "query_start": 6358, "query_end": 7200, "orf_dna_sequence": "ATGAAAACCAACGATAATTATATCGAAGAAGTAACAGCCAAAGTACTCACAAGTGGTAAATACTCCACACTTTATCCACCAACTGTACGACGTGTAACTGAGAGGCTTTTCGATCGATACCCTCCCAAGCAGCTAGAGAAGGAGGTTCGCAAGAAATTGCATCAAGCATATGGTGCTTATATTGGTGGGATCGATGGGAAAAGGTTGGAGAAGAAGATTGAGAAGATAATTCATGAGATACCAAATCCAACTACGGATGAAGCAACTCGTACGGAGTGGGAAAAAGAGATCTGCCTGAAAATATTGAACTTGCACACTTCAACAAATGAGCGAACGGTGGCTTACGATGAGCTTTACCAAAAGATCTTTGAGGTAACAGGGGTTCCAACAAGTATCACCGATGCAGGTTGCGCTTTGAATCCATTTTCTTTTCCATTCTTTACGGAGGCTGGCATGCTTGGGCAATACATAGGTTTCGATCTTGATAAAGGTATGATCGAAGCGATCGAACACTCGTTGAGAACGCTTAACGCCCCAGAGGGTATTGTTGTCAAACAGGGAGATATATTATCCGATCCGTCAGGCGAGAGTGATCTTCTACTTATGTTCAAGCTATATACTCTACTCGATCGGCAGGAAGAGGCCTCTGGTTTGAAAATTCTTCAAGAGTGGAAATACAAAAATGCTGTGATCTCTTTTCCTATTAAAACTATAAGTGGGAGAGATGTTGGGATGGAAGAGAATTACACTGTTAAGTTCGAGAATGATCTTGTTGGGTCAGATCTGAGAATCATGCAAAAATTGAAATTAGGAAACGAGATGTATTTTATCGTATCGAGATTGTAA", "orf_prot_sequence": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "perc_identity": 100.0}}, "NODE_44_length_4295_cov_23.2123_1 # 301 # 1113 # 1 # ID=44_1;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.615": {"gnl|BL_ORD_ID|731|hsp_num:0": {"type_match": "Perfect", "model_id": "783", "orf_strand": "+", "orf_start": 301, "orf_end": 1113, "orf_from": "NODE_44_length_4295_cov_23.2123_1", "model_name": "NDM-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000589", "ARO_name": "NDM-1", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36196": {"category_aro_accession": "3000057", "category_aro_cvterm_id": "36196", "category_aro_name": "NDM beta-lactamase", "category_aro_description": "NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins.", "category_aro_class_name": "AMR Gene Family"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 555.829, "max_identities": 270, "cvterm_id": "35915", "query": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "match": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "sequence_from_db": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "sequence_from_broadstreet": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "dna_sequence_from_broadstreet": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "partial": "0", "query_start": 301, "query_end": 1110, "orf_dna_sequence": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "orf_prot_sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "perc_identity": 100.0}}, "NODE_44_length_4295_cov_23.2123_2 # 1222 # 1482 # 1 # ID=44_2;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.621": {"gnl|BL_ORD_ID|2418|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "determinant of bleomycin resistance", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "200", "model_id": "255", "ARO_accession": "3001205", "ARO_name": "BRP(MBL)", "ARO_category": {"41420": {"category_aro_accession": "3004256", "category_aro_cvterm_id": "41420", "category_aro_name": "Bleomycin resistant protein", "category_aro_description": "Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules.", "category_aro_class_name": "AMR Gene Family"}, "37034": {"category_aro_accession": "3000690", "category_aro_cvterm_id": "37034", "category_aro_name": "bleomycinic acid", "category_aro_description": "Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "37035": {"category_aro_accession": "3000691", "category_aro_cvterm_id": "37035", "category_aro_name": "bleomycin A2", "category_aro_description": "Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "37036": {"category_aro_accession": "3000692", "category_aro_cvterm_id": "37036", "category_aro_name": "bleomycin B2", "category_aro_description": "Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.47103e-61, "max_identities": 86, "bit_score": 177.563, "cvterm_id": "35507", "query": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "match": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "sequence_from_db": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "sequence_from_broadstreet": "MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "dna_sequence_from_broadstreet": "ATGGCTGACCACGTCACCCCCAATCTGCCATCGCGCGATTTCGATGTGACAGAGGCGTTTTATGCGAAGCTGGGCTTTGCGACGAGTTGGAAGGATCGCGGCTGGATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "partial": "0", "query_start": 1222, "query_end": 1479, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "smeD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "284", "ARO_accession": "3003055", "ARO_name": "smeD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.587866, "max_identities": 9, "bit_score": 25.0238, "cvterm_id": "37076", "query": "FPYPDLDPATSSFGCCLRLDDLDAMV", "match": "F    +DP T SFG  +++D+ D ++", "sequence_from_db": "FSEVSVDPTTGSFGLRVKVDNPDGLL", "sequence_from_broadstreet": "MLLSRIRPFALSLAIAATVAACGGQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGDAPAKPAAAAQPAAPAGDAK", "dna_sequence_from_broadstreet": "ATGTTGCTGAGCCGAATCCGACCCTTTGCACTGTCGCTGGCAATCGCCGCGACCGTGGCTGCCTGCGGCGGCCAACCCCAGGCCCCCGAGCAGGGCCCGGGTGACGTCACCGTGGTCACGCTGAAGTCCGAGACCGTGGGCCTGACCCGCGAACTGCCGGGCCGTACCAATGCCTTCCTGGTCGCCGAAGTGCGCCCGCAGGTCAATGGCATCGTGGCCAAGCGCCTGTTTACCGAGGGCGGCATGGTCAAGGCCGGCGAGCCGCTGTACCAGCTCGACGATGCCAGCTACCGGGCCCAGGCCAACAACGCCCGCGCCCAGCTGGCCCGCGCCGAAGCCACCGCCAATGCCGCGCGCCTGAGTGCCAAGCGCATCACCGAGCTGGCCAAGGTCGATGCGGTCAGCCAGCAGGACCTGGAGAACGCCGTCGCCGCGCAGAAGCAGGCCGAGGCCGACGTCGGTGCCGCCAAGGCCTCGCTGGATGCGGCCAACGTCACCCTGGGCTACGCCCGCATCACCGCGCCGATCAGCGGCCGCATCGGCAAGTCCAGCGTCACCCAGGGTGCGCTGGTCAGCGCCGGCCAGGCCAACGCACTGGCCACCGTGCAGCAGCTGGACCCGATCTATGTCGACCTGACCCAGTCCTCGGCCGAGCTGCTGCAGCTGCGCCGCGAACTGGCCGCCGGCCGCCTGCAGGACAACCAGACCCTGCCGGTCAGCATCCTGATGGAAGACGGCAGCACCTTCGAGCACAAGGGCACTCTGGAGTTCTCCGAAGTCAGCGTTGATCCGACCACCGGCAGCTTCGGCCTGCGCGTGAAGGTGGACAACCCGGACGGCCTGCTGATGCCGGGCATGTACGTGCGTGCGGTGATCGGCGGCGGCGTGCGCAGCGACGCGGTGCTGGTGCCGATGCAGGGCATCGCGCGCGATCCGAAGGGCGACACCACCGCGATGGTGGTCGGCAAGGACAACAAGGTCGAAGTGCGCCCGGTCAAGGTCAGCCGCACGGTCGGCGACAAGTGGCTGGTCGAGGACGGCCTGAAGGCCGGTGACAAGGTCATCGTCGAAGGCCTGCAGAAGATCGGCCCCGGCATGCCGGTCAAGGCCACCGAGAAGGGCGACGCACCGGCCAAGCCGGCGGCAGCCGCCCAGCCTGCCGCCCCGGCCGGCGACGCGAAGTAA", "partial": "0", "query_start": 1258, "query_end": 1335, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 34.62}, "gnl|BL_ORD_ID|2150|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "OXA-440", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3510", "ARO_accession": "3003596", "ARO_name": "OXA-440", "ARO_category": {"36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.16443, "max_identities": 12, "bit_score": 22.3274, "cvterm_id": "35507", "query": "TGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQN", "match": "TGW   K PQ+   G   G++  PD  +V    N", "sequence_from_db": "TGWAMDKKPQV---GWLTGWVEQPDGKIVAFALN", "sequence_from_broadstreet": "MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDKKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII", "dna_sequence_from_broadstreet": "ATGAATAAATATTTTACTTGCTATGTGGTTGCTTCTCTTTTTCTTTCTGGTTGTACGGTTCAGCATAATTTAATAAATGAAACCCCGAGTCAGATTGTTCAAGGACATAATCAGGTGATTCATCAATACTTTGATGAAAAAAACACCTCAGGTGTGCTGGTTATTCAAACAGATAAAAAAATTAATCTATATGGTAATGCTCTAAGCCGCGCAAATACAGAATATGTGCCAGCCTCTACATTTAAAATGTTGAATGCCCTGATCGGATTGGAGAACCAGAAAACGGATATTAATGAAATATTTAAATGGAAGGGCGAGAAAAGGTCATTTACCGCTTGGGAAAAAGACATGACACTAGGAGAAGCCATGAAGCTTTCTGCAGTCCCAGTCTATCAGGAACTTGCGCGACGTATCGGTCTTGATCTCATGCAAAAAGAAGTAAAACGTATTGGTTTCGGTAATGCTGAAATTGGACAGCAGGTTGATAATTTCTGGTTGGTAGGACCATTAAAGGTTACGCCTATTCAAGAGGTAGAGTTTGTTTCCCAATTAGCACATACACAGCTTCCATTTAGTGAAAAAGTGCAGGCTAATGTAAAAAATATGCTTCTTTTAGAAGAGAGTAATGGCTACAAAATTTTTGGAAAGACTGGTTGGGCAATGGATAAAAAACCACAAGTGGGCTGGTTGACCGGCTGGGTTGAGCAGCCAGATGGAAAAATTGTCGCTTTTGCATTAAATATGGAAATGCGGTCAGAAATGCCGGCATCTATACGTAATGAATTATTGATGAAATCATTAAAACAGCTGAATATTATTTAA", "partial": "0", "query_start": 1372, "query_end": 1473, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 35.29}, "gnl|BL_ORD_ID|2048|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "TriA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2192", "ARO_accession": "3003679", "ARO_name": "TriA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.55444, "max_identities": 10, "bit_score": 21.557, "cvterm_id": "36804", "query": "LVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDP", "match": "+ +A GA      W R   P +  +GL +G   +P", "sequence_from_db": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEP", "sequence_from_broadstreet": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGEQPAVWLLDQQGKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASRDAVGGGQP", "dna_sequence_from_broadstreet": "ATGTCAGACGCCAGAGGCGCTTTTCATTCCAAAGGTCGCTGGTCGCGGATGGCGCTGCCCGCCATCCTGTGCGCCGGCCTGCTTGTCGGTTGCGGCGCCGAGCCGCCCGCCGAGGAACACGTCCGTGTGCTGGCGCAGACGGTGAAGATGGCCGAGTTCGCCTCGGCCACCTCGATCACCGGCGACATCCAGGCACGGGTACAGGCCGACCAGTCGTTCCGTGTCGGCGGCAAGATCGTCGAGCGCCTGGTCGATGTCGGCGACCACGTCGCGGCTGGCCAGGTGCTGGCGCGGCTCGACCCGCAGGACCAGCGCAGCAACGTGGAGAACGCCCAGGCGGCGGTCGCCGCGCAGCAGGCGCAGTCGAAGCTCGCCGACCTCAACTACCAGCGGCAGAAGGCGCTGCTGCCCAAGGGCTACACCAGCCAGAGCGAGTACGACCAGGCGCTGGCCTCGGTGCGCAGCGCGCAGAGTTCGCTGAAGGCCGCCCAGGCGCAGTTGGCCAACGCCCGCGACCTGCTTTCCTATACCGAGCTGCGTGCCTCCGACGCCGGGGTCATCACCGCCCGCCAGGCCGAGGTCGGCCAGGTGGTGCAGGCCACCGTGCCGATCTTCACCCTGGCCCGCGACGGCGAGCGCGACGCGGTGTTCAACGTCTACGAGTCGTTGTTCAGCCACGATGTCGACGGCCAGCGGATCACCGTCAGCCTGCTCGGCAAGCCGGAAGTCACCGCCAGCGGCAAGGTCCGCGAGATCACCCCCACGGTGGACGAGCGCAGCGGTACGCTGAAGGTCAAGGTCGGCCTCGACTCGGTGCCGGCGGAAATGAGCCTCGGCAGCGTGGTCAACGCCAGCGTCGCCGCGCCGGCCGAGCACAGCGTGGTGCTGCCCTGGTCGGCGCTGTCCAAGGTCGGCGAGCAGCCGGCGGTCTGGTTGCTCGACCAGCAAGGCAAGGCGCGTCTGCAACCGGTGCGGGTGGCACGCTACGCCAGCGAGAAGGTGGTCATCGACGGTGGCCTGGAGGCGGGCCAGACGGTGGTCACGGTGGGCGGCCAACTGCTCCATCCGGGCCAGGTGGTCGAGGTGGCCCAGCCGCCGCAGCCGACCCAGAGCACCGCCAGCCGCGACGCCGTGGGCGGAGGCCAGCCATGA", "partial": "0", "query_start": 1339, "query_end": 1443, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 28.57}}, "NODE_44_length_4295_cov_23.2123_3 # 1846 # 2862 # -1 # ID=44_3;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.571": {"gnl|BL_ORD_ID|582|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "622", "ARO_accession": "3002136", "ARO_name": "DHA-7", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 265, "bit_score": 538.88, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGSGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTCCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|817|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "868", "ARO_accession": "3002132", "ARO_name": "DHA-1", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 265, "bit_score": 538.11, "cvterm_id": "35750", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|781|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "829", "ARO_accession": "3002148", "ARO_name": "DHA-17", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 537.339, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVA VVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAVVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAVVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGTGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1332|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1418", "ARO_accession": "3002135", "ARO_name": "DHA-6", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 536.954, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKS SKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCACCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1694|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1793", "ARO_accession": "3002145", "ARO_name": "DHA-14", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 536.569, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1599|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1695", "ARO_accession": "3002138", "ARO_name": "DHA-5", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 535.413, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKG+PYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGACATTCCCGGGATGGCGGTTGCCGTCTCTGTAAAGGGCAGGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGCATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGTTACTATAAAACCGCCGCGATTAATCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1900|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2015", "ARO_accession": "3002134", "ARO_name": "DHA-3", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 535.028, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVP+SAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMN+EPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNIEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNIEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGATAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCAGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATTGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1693|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1792", "ARO_accession": "3002151", "ARO_name": "DHA-20", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 535.028, "cvterm_id": "36934", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCCCTGCTGGCATTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGACGCTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGTTGGATCTGGCCACCTACACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACCGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1135|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1207", "ARO_accession": "3002144", "ARO_name": "DHA-13", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 534.258, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|26|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "32", "ARO_accession": "3002146", "ARO_name": "DHA-15", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 534.258, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPG MRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGYMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGYMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCTATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2744|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3581", "ARO_accession": "3002140", "ARO_name": "DHA-9", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 533.487, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "M KS+SATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQS YAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGACAAAATCTGTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCATTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "1", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1555|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1649", "ARO_accession": "3002152", "ARO_name": "DHA-21", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 261, "bit_score": 533.102, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCTGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGACGTTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGCTGGATCTGGCTACCTACACCGCAGGCGGGCTGCCGTTACAGGTGCCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACGGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.49, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1004|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1071", "ARO_accession": "3002153", "ARO_name": "DHA-22", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 533.102, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDS IKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALND AAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSAIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDLAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSAIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDLAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCGCCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCAGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCTGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1780|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1883", "ARO_accession": "3002141", "ARO_name": "DHA-10", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 260, "bit_score": 531.561, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPD VKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDEVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDEVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCTGTCTCTGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGACGCTGAATGACCCGGCGGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAAGGGATCACGCTGCTGGATCTGGCCACCTACACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGAGGTGAAAAGCCGTGCGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACCGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCAGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACTGCCGCGATTAATCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGCGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.11, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|166|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "180", "ARO_accession": "3002150", "ARO_name": "DHA-19", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 531.561, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSP QLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPEQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPEQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGAACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1385|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1472", "ARO_accession": "3002149", "ARO_name": "DHA-18", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 260, "bit_score": 528.865, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKE ALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPES QS+YAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESVQSRYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESVQSRYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACTATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTATCCGTAAAGGGCAAGCCCTATTATTTTAACTATGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGACGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAATGCGGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGATTATCTCACACCTTTATTACCGTGCCGGAAAGTGTGCAAAGCCGGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.11, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|294|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "315", "ARO_accession": "3002133", "ARO_name": "DHA-2", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 258, "bit_score": 528.48, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYT GGLPLQVPDAVK+RA+LL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAELLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAELLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCTGTAAAGGGCAAGCCCTATTATTTCAATTATGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTGGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGATGTTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGCTGGATCTGGCCACCTACACCACAGGCGGGCTGCCGTTACAGGTGCCGGATGCGGTGAAAAACCGTGCGGAACTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGATTATCTCACACCTTTATTACCGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAGTCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAGATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCACTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCGCTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 97.36, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|797|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "846", "ARO_accession": "3002143", "ARO_name": "DHA-12", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 255, "bit_score": 522.316, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD++AKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM+LNDPAAKY+PEL  PQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLT RIL+PLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVEAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMSLNDPAAKYRPELTQPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTTRILSPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVEAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMSLNDPAAKYRPELTQPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTTRILSPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIVNGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCCGCCGCTGACAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCAGTTGCTGTTTCCGTAAAGGGCAAGCCCTATTATTTCAACTATGGTTTTGCCGATGTTGAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCAGTTTCCGTGGCGAAAAAAGAGATGTCCCTGAATGACCCGGCGGCAAAATACCGGCCTGAACTGACACAACCGCAGTGGAAGGGGATCACATTGCTCGATCTGGCTACTTATACCGCAGGCGGGCTGCCGTTACAGGTGCCGGACGCGGTGAAAAGCCGTGCGGATCTGTTGCATTTCTATCAGCAGTGGCAGCCGTCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCCGCAGGAATGCCGTATGAGCAGTTGCTGACCACGCGTATCCTGTCTCCGCTGGGGTTATCACACACCTTTATTACCGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCAGAATCTTACGGGGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAACCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGATTGGCCGCAGCAGAAGGACATGATCGTGAACGGCGTGACCAATGAAGTCGCATTGCAGCCGCATCCGGTAACCGACAATCAGGTGCAGCCGTACAACCGCGCTTCCTGGGTGCATAAAACGGGGGCGACAACCGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATCCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|393|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "423", "ARO_accession": "3002147", "ARO_name": "DHA-16", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.29146e-178, "max_identities": 243, "bit_score": 495.352, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATL+SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKE +LNDPA KYQPEL  PQWKGITLLDLATYTAGGLPLQVP+AVKS  DLL+FYQQWQPS +PG MRLYANSSIGLFGALTA AAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN +PVRV+ G LDAESYGVKSASKDMLRWAE+NM PSRAGNA", "sequence_from_db": "MKKSLSATLVSALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETSLNDPAVKYQPELTQPQWKGITLLDLATYTAGGLPLQVPEAVKSSEDLLHFYQQWQPSWQPGKMRLYANSSIGLFGALTATAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNNQPVRVTGGPLDAESYGVKSASKDMLRWAEINMSPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLVSALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETSLNDPAVKYQPELTQPQWKGITLLDLATYTAGGLPLQVPEAVKSSEDLLHFYQQWQPSWQPGKMRLYANSSIGLFGALTATAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNNQPVRVTGGPLDAESYGVKSASKDMLRWAEINMSPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGGTTTCCGCCCTGCTGGCCTTTTCTGCCCCGGGGTTCTCTGCCGCTGATAATGTCGCGGCAGTCGTCGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATCCCCGGGATGGCGGTTGCTGTCTCCGTAAAGGGAAAACCGTATTACTTCAACTATGGTTTTGCGGATGTGCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAACTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGACGTCGCTGAATGACCCGGCAGTCAAATACCAGCCTGAACTGACACAGCCGCAGTGGAAAGGGATCACATTACTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTGCCGGAAGCGGTGAAAAGCAGTGAGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCATGGCAACCGGGAAAGATGCGTCTGTATGCGAACAGCAGTATCGGCCTGTTCGGTGCGCTGACCGCGACAGCGGCGGGAATGCCTTATGAGCAGCTGCTGACCGCACGTATCCTGGCGCCGCTGGGGTTATCACATACCTTTATTACTGTACCGGAAAGTGCGCAAAGTCAGTATGCATACGGTTATAAAAACAATCAGCCGGTACGGGTGACGGGGGGACCGCTCGATGCGGAATCTTACGGGGTAAAATCCGCCTCAAAAGATATGCTGCGCTGGGCAGAAATCAATATGTCGCCGTCACGGGCGGGCAATGCGGATCTGGAAATGGCGATGTATCTCGCACAGACCCGTTACTATAAAACGGCGGCAATCAACCAGGGACTGGGCTGGGAGATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAATGAAGTGGCATTGCAGCCGCATCCGGTAACGGATAATCAGGTTCAGCCGTATAACCGCGCTTCCTGGGTACATAAAACAGGAGCAACAACCGGTTTCGGTGCTTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCAAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 91.7}, "gnl|BL_ORD_ID|1415|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-108", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1504", "ARO_accession": "3002120", "ARO_name": "CMY-108", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.66173e-110, "max_identities": 160, "bit_score": 322.398, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWHILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAGGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCACATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.61}, "gnl|BL_ORD_ID|1728|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-87", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1829", "ARO_accession": "3002100", "ARO_name": "CMY-87", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.04103e-109, "max_identities": 159, "bit_score": 321.627, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ LNDP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAACGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|37|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-114", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "46", "ARO_accession": "3002125", "ARO_name": "CMY-114", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.04103e-109, "max_identities": 158, "bit_score": 321.627, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATTACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1809|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-47", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1915", "ARO_accession": "3002058", "ARO_name": "CMY-47", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.62599e-109, "max_identities": 157, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGAGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1697|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-119", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1796", "ARO_accession": "3002130", "ARO_name": "CMY-119", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.66175e-109, "max_identities": 159, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWIQVNMDASRVQEKMLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAAEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAACTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGTTGGATTCAGGTCAACATGGATGCCAGCCGCGTTCAGGAGAAAATGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGCTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|729|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-113", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "775", "ARO_accession": "3002124", "ARO_name": "CMY-113", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.66175e-109, "max_identities": 158, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDAS", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.08}, "gnl|BL_ORD_ID|193|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-105", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "208", "ARO_accession": "3002117", "ARO_name": "CMY-105", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8128e-109, "max_identities": 157, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1965|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-36", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2134", "ARO_accession": "3002047", "ARO_name": "CMY-36", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.02107e-109, "max_identities": 159, "bit_score": 320.857, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG   +A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVPE+ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACTGTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCTTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCAGAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCACAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|241|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-65", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "261", "ARO_accession": "3002078", "ARO_name": "CMY-65", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.35345e-109, "max_identities": 157, "bit_score": 320.857, "cvterm_id": "39093", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|316|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-51", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "340", "ARO_accession": "3002062", "ARO_name": "CMY-51", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4052e-109, "max_identities": 158, "bit_score": 320.857, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ LNDP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAACGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|641|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "683", "ARO_accession": "3002088", "ARO_name": "CMY-75", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.65252e-109, "max_identities": 157, "bit_score": 320.857, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1109|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1178", "ARO_accession": "3002094", "ARO_name": "CMY-81", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15666e-109, "max_identities": 157, "bit_score": 320.472, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIVNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIVNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGTCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATTACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|795|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-117", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "844", "ARO_accession": "3002128", "ARO_name": "CMY-117", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.48124e-109, "max_identities": 158, "bit_score": 320.472, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRA", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S A", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHA", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHAQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGCTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2631, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.62}, "gnl|BL_ORD_ID|854|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-50", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "911", "ARO_accession": "3002061", "ARO_name": "CMY-50", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.59669e-109, "max_identities": 158, "bit_score": 320.472, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWCIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGTGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCTAACCCGGTCCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1074|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-86", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1140", "ARO_accession": "3002099", "ARO_name": "CMY-86", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.14286e-109, "max_identities": 159, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEVAWHILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTCTCCACGTTTGCCGCAGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGTGGCCTGGCACATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|1163|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-53", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1236", "ARO_accession": "3002064", "ARO_name": "CMY-53", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.18816e-109, "max_identities": 158, "bit_score": 320.087, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGICLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGICLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCTGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAATAAAAGCTATCCTAACCCTGCCCGCGTCGAGGCGGCCTGGCGTATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1172|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-72", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1247", "ARO_accession": "3002085", "ARO_name": "CMY-72", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.93021e-109, "max_identities": 157, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|791|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-44", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "839", "ARO_accession": "3002055", "ARO_name": "CMY-44", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.27473e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCACCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1412|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-49", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1501", "ARO_accession": "3002060", "ARO_name": "CMY-49", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.61745e-109, "max_identities": 157, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV V+PGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALHTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACAGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTACTCCTGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCCCGTTGGATTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGTGACAGCAAAGTGGCATTGGCAGCGCTTCACACCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCATTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|339|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-83", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "364", "ARO_accession": "3002096", "ARO_name": "CMY-83", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.19504e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL  N +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVNPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVNPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAACCCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGGCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCCCTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAAGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|77|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-55", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "88", "ARO_accession": "3002066", "ARO_name": "CMY-55", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.33125e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACATGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGAAGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|288|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-35", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "309", "ARO_accession": "3002046", "ARO_name": "CMY-35", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.68503e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACATGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|267|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-60", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "288", "ARO_accession": "3002073", "ARO_name": "CMY-60", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.21376e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTATCGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1097|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-94", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1163", "ARO_accession": "3002107", "ARO_name": "CMY-94", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.70013e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVASAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATCGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1574|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-68", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1668", "ARO_accession": "3002081", "ARO_name": "CMY-68", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95547e-109, "max_identities": 156, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPG+AVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGIAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGIAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATTGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|287|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-118", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "308", "ARO_accession": "3002129", "ARO_name": "CMY-118", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95547e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|2685|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-132", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "550", "model_id": "3577", "ARO_accession": "3003652", "ARO_name": "CMY-132", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.04245e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|969|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-102", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1029", "ARO_accession": "3002114", "ARO_name": "CMY-102", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.58468e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNCTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNCTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATTGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|560|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "600", "ARO_accession": "3002013", "ARO_name": "CMY-2", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35927": {"category_aro_accession": "0000008", "category_aro_cvterm_id": "35927", "category_aro_name": "cefoxitin", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.67854e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|2701|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-133", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3578", "ARO_accession": "3003653", "ARO_name": "CMY-133", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.06436e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAACGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|676|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-33", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "719", "ARO_accession": "3002044", "ARO_name": "CMY-33", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.17469e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|83|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-56", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "95", "ARO_accession": "3002067", "ARO_name": "CMY-56", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.46733e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAACTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|662|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-116", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "705", "ARO_accession": "3002127", "ARO_name": "CMY-116", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.57084e-109, "max_identities": 157, "bit_score": 319.316, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTAGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1346|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1433", "ARO_accession": "3002029", "ARO_name": "CMY-18", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.66286e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|491|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "525", "ARO_accession": "3002024", "ARO_name": "CMY-13", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.67549e-109, "max_identities": 157, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1034|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1103", "ARO_accession": "3002028", "ARO_name": "CMY-17", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.78127e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTTGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1488|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1585", "ARO_accession": "3002086", "ARO_name": "CMY-73", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.17673e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV V+PGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTCTCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTTGCCAGAACTGACAGGCAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACAGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTACTCCTGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCCCGTTGGATTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCACCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGTTCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|901|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-69", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "963", "ARO_accession": "3002082", "ARO_name": "CMY-69", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.17673e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALPALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGCCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1193|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-115", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1268", "ARO_accession": "3002126", "ARO_name": "CMY-115", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.1896e-108, "max_identities": 157, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  KGKPYYF +G ADI    PVT++TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM  W + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYKGKPYYFTWGKADIANNHPVTQHTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYKGKPYYFTWGKADIANNHPVTQHTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACAAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCATACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCACTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTATCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1451|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1543", "ARO_accession": "3002033", "ARO_name": "CMY-22", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.20261e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGTACTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1761|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-67", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1864", "ARO_accession": "3002080", "ARO_name": "CMY-67", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.24248e-108, "max_identities": 157, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEVAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGTGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|792|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "840", "ARO_accession": "3002031", "ARO_name": "CMY-20", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.32709e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCCGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGTTTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTCCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1818|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1926", "ARO_accession": "3002045", "ARO_name": "CMY-34", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.34075e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1081|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-63", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1147", "ARO_accession": "3002076", "ARO_name": "CMY-63", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.75958e-108, "max_identities": 158, "bit_score": 318.546, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|86|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-48", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "98", "ARO_accession": "3002059", "ARO_name": "CMY-48", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8782e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|260|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-110", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "281", "ARO_accession": "3002071", "ARO_name": "CMY-110", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.9195e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSKFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSKFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWGIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCAAGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGGGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1494|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-64", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1591", "ARO_accession": "3002077", "ARO_name": "CMY-64", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.11684e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMA+AV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTATTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAAGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|725|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-24", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "771", "ARO_accession": "3002035", "ARO_name": "CMY-24", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.25955e-108, "max_identities": 158, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTATACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|653|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-66", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "695", "ARO_accession": "3002079", "ARO_name": "CMY-66", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.33447e-108, "max_identities": 156, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDAS", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.32}, "gnl|BL_ORD_ID|1103|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-46", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1170", "ARO_accession": "3002057", "ARO_name": "CMY-46", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.38579e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPKNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPKNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGAAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACACTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|162|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "176", "ARO_accession": "3002036", "ARO_name": "CMY-25", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.51909e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACTGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|82|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "94", "ARO_accession": "3002092", "ARO_name": "CMY-79", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.68892e-108, "max_identities": 156, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQDKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGATAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1400|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-37", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1489", "ARO_accession": "3002048", "ARO_name": "CMY-37", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.19987e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY  EL   QW+GI+LL LATYTAGGLPLQ+PD V  +  LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWSELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWSELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAAIPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPIRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGTCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAACCGCATTACTGCACTTTTATCAAAACTGGCAGCCTCAATGGGCTCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAGCCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCACGCTGGGTTCAGGCCAACATGGATGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAGGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGATTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTATCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|839|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "894", "ARO_accession": "3002103", "ARO_name": "CMY-90", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.23485e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+P  V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGGTGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1948|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2065", "ARO_accession": "3002016", "ARO_name": "CMY-5", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36788", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+  +DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGTTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACTTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1607|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-57", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1704", "ARO_accession": "3002068", "ARO_name": "CMY-57", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQ DAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAATTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-111", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1638", "ARO_accession": "3002122", "ARO_name": "CMY-111", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36783", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLD E+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDVEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDVEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGTCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1595|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1691", "ARO_accession": "3002042", "ARO_name": "CMY-31", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.52883e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACGACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|630|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-27", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "672", "ARO_accession": "3002038", "ARO_name": "CMY-27", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.8079e-108, "max_identities": 158, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGTGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1878|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1988", "ARO_accession": "3002018", "ARO_name": "CMY-7", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.15396e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|280|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-95", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "301", "ARO_accession": "3002108", "ARO_name": "CMY-95", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.15396e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVASAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGCTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATCGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|835|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "889", "ARO_accession": "3002087", "ARO_name": "CMY-74", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.68171e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRVGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTGTTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAATAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|617|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-104", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "658", "ARO_accession": "3002116", "ARO_name": "CMY-104", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.83694e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "39654", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   P   RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNHTITPLMQKQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPSTKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASQ", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNHTITPLMQKQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPSTKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVDAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCACACCATCACCCCGTTGATGCAGAAGCAGGCTATTCCGGGGATGGCCGTTGCAGTTATCTACCAGGGTAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGTGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAGCCACAATGGACTCCGAGCACTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCGATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAAAAAACACTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGTTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTACATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGCCCGCGTCGATGCAGCCTGGCGTATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|465|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-28", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "495", "ARO_accession": "3002039", "ARO_name": "CMY-28", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.83694e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|2505|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2843", "ARO_accession": "3004290", "ARO_name": "Escherichia coli ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.01027e-108, "max_identities": 153, "bit_score": 317.39, "cvterm_id": "36849", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": " K +L A LI+A    S   F+A   +  +V  TI PL+ QQ IPGMAVAV  +GKPYYF +G+ADI  KQPVT+ TLFELGSVSKTFTGVLG  ++A+ E+ L+DP  KY PEL   QW GITLL LATYTAGGLPLQVPD VKS +DLL FYQ WQP+  PG  RLYANSSIGLFGAL    +G+ +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  +DM RW + N++P", "sequence_from_db": "FKTTLCALLITA----SCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKP", "sequence_from_broadstreet": "MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ", "dna_sequence_from_broadstreet": "ATGTTCAAAACGACGCTCTGCGCCTTATTAATTACCGCCTCTTGCTCCACATTTGCTGCCCCTCAACAAATCAACGATATTGTGCATCGCACAATTACCCCGCTTATAGAGCAACAAAAGATCCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTAAACCTTATTACTTTACCTGGGGCTATGCGGACATCGCCAAAAAGCAGCCCGTCACACAGCAAACGTTGTTTGAGTTAGGTTCGGTCAGCAAAACATTTACTGGCGTGCTTGGTGGCGACGCTATTGCTCGAGGGGAAATCAAGTTAAGCGATCCCACAACAAAATACTGGCCTGAACTTACCGCTAAACAGTGGAATGGGATCACACTATTACATCTCGCAACCTACACTGCTGGCGGCCTGCCATTGCAGGTGCCGGATGAGGTGAAATCCTCAAGCGACTTGCTGCGCTTCTATCAAAACTGGCAGCCTGCATGGGCTCCAGGAACACAACGTCTGTATGCCAACTCCAGTATCGGTTTGTTCGGCGCACTGGCTGTGAAGCCGTCTGGTTTGAGTTTTGAGCAGGCGATGCAAACTCGTGTCTTCCAGCCACTCAAACTCAACCATACGTGGATTAATGTACCGCCCGCAGAAGAAAAGAATTACGCCTGGGGATATCGCGAAGGTAAGGCAGTGCATGTTTCGCCTGGGGCGTTAGATGCTGAAGCTTATGGTGTGAAGTCGACCATTGAAGATATGGCCCGCTGGGTGCAAAGCAATTTAAAACCCCTTGATATCAATGAGAAAACGCTTCAACAAGGGATACAACTGGCACAATCTCGCTACTGGCAAACCGGCGATATGTATCAGGGCCTGGGCTGGGAAATGCTGGACTGGCCGGTAAATCCTGACAGCATCATTAACGGCAGTGACAATAAAATTGCACTGGCAGCACGCCCCGTAAAAGCGATTACGCCCCCAACTCCTGCAGTACGCGCATCATGGGTACATAAAACAGGGGCGACCGGCGGATTTGGTAGCTATGTCGCGTTTATTCCAGAAAAAGAGCTGGGTATCGTGATGCTGGCAAACAAAAACTATCCCAATCCAGCGAGAGTCGACGCCGCCTGGCAGATTCTTAACGCTCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.07}, "gnl|BL_ORD_ID|2504|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2843", "ARO_accession": "3004290", "ARO_name": "Escherichia coli ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.01027e-108, "max_identities": 153, "bit_score": 317.39, "cvterm_id": "36849", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": " K +L A LI+A    S   F+A   +  +V  TI PL+ QQ IPGMAVAV  +GKPYYF +G+ADI  KQPVT+ TLFELGSVSKTFTGVLG  ++A+ E+ L+DP  KY PEL   QW GITLL LATYTAGGLPLQVPD VKS +DLL FYQ WQP+  PG  RLYANSSIGLFGAL    +G+ +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  +DM RW + N++P", "sequence_from_db": "FKTTLCALLITA----SCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKP", "sequence_from_broadstreet": "MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ", "dna_sequence_from_broadstreet": "ATGTTCAAAACGACGCTCTGCGCCTTATTAATTACCGCCTCTTGCTCCACATTTGCTGCCCCTCAACAAATCAACGATATTGTGCATCGCACAATTACCCCGCTTATAGAGCAACAAAAGATCCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTAAACCTTATTACTTTACCTGGGGCTATGCGGACATCGCCAAAAAGCAGCCCGTCACACAGCAAACGTTGTTTGAGTTAGGTTCGGTCAGCAAAACATTTACTGGCGTGCTTGGTGGCGACGCTATTGCTCGAGGGGAAATCAAGTTAAGCGATCCCACAACAAAATACTGGCCTGAACTTACCGCTAAACAGTGGAATGGGATCACACTATTACATCTCGCAACCTACACTGCTGGCGGCCTGCCATTGCAGGTGCCGGATGAGGTGAAATCCTCAAGCGACTTGCTGCGCTTCTATCAAAACTGGCAGCCTGCATGGGCTCCAGGAACACAACGTCTGTATGCCAACTCCAGTATCGGTTTGTTCGGCGCACTGGCTGTGAAGCCGTCTGGTTTGAGTTTTGAGCAGGCGATGCAAACTCGTGTCTTCCAGCCACTCAAACTCAACCATACGTGGATTAATGTACCGCCCGCAGAAGAAAAGAATTACGCCTGGGGATATCGCGAAGGTAAGGCAGTGCATGTTTCGCCTGGGGCGTTAGATGCTGAAGCTTATGGTGTGAAGTCGACCATTGAAGATATGGCCCGCTGGGTGCAAAGCAATTTAAAACCCCTTGATATCAATGAGAAAACGCTTCAACAAGGGATACAACTGGCACAATCTCGCTACTGGCAAACCGGCGATATGTATCAGGGCCTGGGCTGGGAAATGCTGGACTGGCCGGTAAATCCTGACAGCATCATTAACGGCAGTGACAATAAAATTGCACTGGCAGCACGCCCCGTAAAAGCGATTACGCCCCCAACTCCTGCAGTACGCGCATCATGGGTACATAAAACAGGGGCGACCGGCGGATTTGGTAGCTATGTCGCGTTTATTCCAGAAAAAGAGCTGGGTATCGTGATGCTGGCAAACAAAAACTATCCCAATCCAGCGAGAGTCGACGCCGCCTGGCAGATTCTTAACGCTCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.07}, "gnl|BL_ORD_ID|1279|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-101", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1364", "ARO_accession": "3002113", "ARO_name": "CMY-101", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.10717e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACGCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCATACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGTTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|251|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "271", "ARO_accession": "3002015", "ARO_name": "CMY-4", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.45145e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCAGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|711|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-80", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "757", "ARO_accession": "3002093", "ARO_name": "CMY-80", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.57129e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAAD---NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GK YYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+I VP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEPQIADIVNRTITPLMQEQAIPGMAVAVIYQGKSYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEPQIADIVNRTITPLMQEQAIPGMAVAVIYQGKSYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACCACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAATCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTAAAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGTATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1021|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1089", "ARO_accession": "3002025", "ARO_name": "CMY-14", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.6322e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGATAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1323|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1409", "ARO_accession": "3002017", "ARO_name": "CMY-6", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.75601e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTTGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1879|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1990", "ARO_accession": "3002095", "ARO_name": "CMY-82", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.27909e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCCCTGGCGGTCAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCGTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|622|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-43", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "664", "ARO_accession": "3002054", "ARO_name": "CMY-43", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.34773e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLF AL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGCCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1556|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1650", "ARO_accession": "3002026", "ARO_name": "CMY-15", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.70237e-108, "max_identities": 158, "bit_score": 317.005, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|804|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-58", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "854", "ARO_accession": "3002072", "ARO_name": "CMY-58", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.70237e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+Y VKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATTGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1365|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-112", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1454", "ARO_accession": "3002123", "ARO_name": "CMY-112", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.77563e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1539|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1634", "ARO_accession": "3002091", "ARO_name": "CMY-78", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.07681e-108, "max_identities": 156, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+P  V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGGTGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1321|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-62", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1407", "ARO_accession": "3002075", "ARO_name": "CMY-62", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.55385e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLF AL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTAGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|262|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-85", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "283", "ARO_accession": "3002098", "ARO_name": "CMY-85", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.97586e-108, "max_identities": 156, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KP+ VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPLHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPLHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQLGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTTTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCTGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|2601|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "BIL-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "780", "model_id": "3562", "ARO_accession": "3004755", "ARO_name": "BIL-1", "ARO_category": {"42866": {"category_aro_accession": "3004754", "category_aro_cvterm_id": "42866", "category_aro_name": "BIL Beta-lactamase", "category_aro_description": "BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.15119e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+ Y+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGRDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWAYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGRDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWAYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDTKVALAAVPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVIVANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCCGCGATGCTATCGCGCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGCGTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACACGAAAGTGGCATTGGCAGCCGTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATCGTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|52|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-42", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "62", "ARO_accession": "3002053", "ARO_name": "CMY-42", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35927": {"category_aro_accession": "0000008", "category_aro_cvterm_id": "35927", "category_aro_name": "cefoxitin", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.15119e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHSSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHSSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACAGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1496|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-99", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1593", "ARO_accession": "3002070", "ARO_name": "CMY-99", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.06971e-107, "max_identities": 157, "bit_score": 316.62, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPATAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCACCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1738|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-59", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1840", "ARO_accession": "3002069", "ARO_name": "CMY-59", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.08024e-107, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "GPGHLFAFNYGTDFMMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "GGGCCCGGACACCTTTTTGCTTTTAATTACGGAACTGATTTCATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGCTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|743|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "790", "ARO_accession": "3002043", "ARO_name": "CMY-32", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.15429e-107, "max_identities": 157, "bit_score": 316.62, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSP QLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGAACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|918|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "972", "ARO_accession": "3002034", "ARO_name": "CMY-23", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30093e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35671", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDA +YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGGAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|593|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CFE-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "636", "ARO_accession": "3001856", "ARO_name": "CFE-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.34406e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVVDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVVDMTRWVQANMDASQVQEKTLQQGIKLAQSRYWRIGDMYQGLGWEMLNWPVKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTTTCCACCTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTACCAGGGAAAACCTTATTACTTTACCTGGGGTAAAGCTGATATCGCCAATAACCGTCCAGTCACTCAGCAAACGCTGTTTGAACTCGGCTCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCTCGCGGCGAAATCAAGCTCAGCGATCCGGTCACGCAATACTGGCCTGAGCTGACGGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCGACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCCGACGACGTCACGGATAAAGCCGCCTTACTGCGTTTTTATCAAAACTGGCAGCCACAATGGGCACCGGGCGCTAAACGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGCATGAGCTACGAAGAGGCGATGACCACCCGCGTCCTGCAGCCCTTAAAACTGGCGCATACATGGATTACGGTTCCACAGAGCGAACAAAAAGATTATGCATTGGGCTATCGCGAAGGAAAGCCTGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTATGGGGTAAAATCAAGCGTTGTCGATATGACCCGCTGGGTCCAGGCCAACATGGATGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGAATCAAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGTCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCAATAATTAACGGTAGCGACAGCAAAGTGGCGCTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCGCCTGCTGTGAAAGCATCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATTGTGATGCTGGCAAACAAGAGCTATCCAAACCCTGCTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1155|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1228", "ARO_accession": "3002041", "ARO_name": "CMY-30", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35875e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|54|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-70", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "64", "ARO_accession": "3002083", "ARO_name": "CMY-70", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.4662e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ ++ R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMSKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMSKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACGCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATAGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCAGTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCAGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGTCCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCATACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|940|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "996", "ARO_accession": "3002090", "ARO_name": "CMY-77", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.51481e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "39655", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1443|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1535", "ARO_accession": "3002027", "ARO_name": "CMY-16", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.70724e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|237|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "256", "ARO_accession": "3002032", "ARO_name": "CMY-21", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.70724e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGAAAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1405|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LAT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1494", "ARO_accession": "3001857", "ARO_name": "LAT-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.80261e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL + L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG   +A+ E+ L+DP  KY PEL   +W+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCSAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKKWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCSALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKKWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTCCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAACCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGGAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACTGTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAAAAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCTTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACGACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1774|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1877", "ARO_accession": "3002023", "ARO_name": "CMY-12", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.82231e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|426|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-29", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "460", "ARO_accession": "3002040", "ARO_name": "CMY-29", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.82231e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGTTCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1655|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-93", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1756", "ARO_accession": "3002106", "ARO_name": "CMY-93", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.00963e-107, "max_identities": 156, "bit_score": 315.849, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+  +DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRVGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGTTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCCCTGGCGGTCAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTGTTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|700|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-40", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "745", "ARO_accession": "3002051", "ARO_name": "CMY-40", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.19224e-107, "max_identities": 157, "bit_score": 315.849, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM  W + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGYTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGGTTATCTACCAGGGAAAACCCTATTATTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGTCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCACGCTGGCGGTGAAACCCTCCGGTATGAGCTACGAAGAGGCGATGACCAGACGCGTTCTGCAGCCATTAAAGCTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCACTGGGTACAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAACAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCCGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTACACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1903|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2018", "ARO_accession": "3002089", "ARO_name": "CMY-76", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.75446e-107, "max_identities": 156, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|205|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-100", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "221", "ARO_accession": "3002112", "ARO_name": "CMY-100", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.78457e-107, "max_identities": 156, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL+FYQ WQP    G  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLHFYQNWQPQWASGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLHFYQNWQPQWASGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGTTCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCAGTACTGGCCTGAACTGACGGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCATTACTACACTTTTATCAAAACTGGCAGCCGCAATGGGCCTCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCTTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGAATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGTTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTAGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1912|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-84", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2027", "ARO_accession": "3002097", "ARO_name": "CMY-84", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.97226e-107, "max_identities": 155, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY P L   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPALTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPALTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGCACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTATCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|1019|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-41", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1086", "ARO_accession": "3002052", "ARO_name": "CMY-41", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.61467e-107, "max_identities": 155, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+A      +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCACAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|154|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-39", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "167", "ARO_accession": "3002050", "ARO_name": "CMY-39", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.61467e-107, "max_identities": 157, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+I VP+S Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTAAAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1513|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-38", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1613", "ARO_accession": "3002049", "ARO_name": "CMY-38", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.65418e-107, "max_identities": 157, "bit_score": 315.464, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQL+AE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTAACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|2712|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-135", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "740", "model_id": "3579", "ARO_accession": "3004778", "ARO_name": "CMY-135", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.64148e-107, "max_identities": 155, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI     VT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHLVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHLVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCTAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|512|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-71", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "550", "ARO_accession": "3002084", "ARO_name": "CMY-71", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.69221e-107, "max_identities": 157, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A  V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPFSTFAAAKTEQQIADTVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPFSTFAAAKTEQQIADTVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTCTCCACGTTTGCCGCAGCCAAAACAGAACAACAGATTGCCGATACCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGGTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1426|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-45", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1516", "ARO_accession": "3002056", "ARO_name": "CMY-45", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.79535e-107, "max_identities": 156, "bit_score": 315.079, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPL++PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTVGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGAAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGTTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1646|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-103", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1747", "ARO_accession": "3002115", "ARO_name": "CMY-103", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.90075e-107, "max_identities": 155, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+A      +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQGKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCACAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAAGGGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|1288|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-26", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1373", "ARO_accession": "3002037", "ARO_name": "CMY-26", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.17449e-107, "max_identities": 156, "bit_score": 315.079, "cvterm_id": "36788", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVAV  +GK YYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+ I+LL LATYTAGGLPLQ+PD V  +  LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKTYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKTYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAAACCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGATATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAACCGCATTACTGCACTTTTATCAAAACTGGCAGCCGCAATGGGCTCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAGCCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|638|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-54", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "680", "ARO_accession": "3002065", "ARO_name": "CMY-54", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.00264e-106, "max_identities": 158, "bit_score": 314.309, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQ--LDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQ  LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.4}, "gnl|BL_ORD_ID|813|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-61", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "864", "ARO_accession": "3002074", "ARO_name": "CMY-61", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.76199e-106, "max_identities": 155, "bit_score": 313.153, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "M +  +A L++A  +FS   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MNRYAAALLLTA--SFST--FAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMNRYAAALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAATCGTTATGCTGCAGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|276|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-98", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "297", "ARO_accession": "3002111", "ARO_name": "CMY-98", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.32545e-105, "max_identities": 155, "bit_score": 311.227, "cvterm_id": "36915", "query": "KSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "+SL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT  TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "QSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQ", "sequence_from_broadstreet": "MAAQSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQVQEKTLRQGIEIAQARYWHIGDMYQGLGWEMLNWPVNADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRI", "dna_sequence_from_broadstreet": "ATGGCTGCACAATCGTTATGCTGCGCGTTGCTGCTGACAGCCTCTTTCTCTACGTTTGCCGCCGCAAAAACAGAACAACAGATTGCCGATATCGTAAACCGTACCATCACACCGCTGATGCAAGAACAGGCTATTCCGGGTATGGCCGTAGCAATTATCTACCAGGGAAAACCCTATTACTTTACCTGGGGGAAAGCCGATATCGCCAATGACCGCCCCGTCACCCGGCAAACGCTGTTTGAGCTTGGATCGGTAAGTAAGACGTTTAACGGTGTGCTGGGCGGCGATGCTATCGCCCGTGGTGAAATTAAGCTCAGCGATCCGGTCACCCAATACTGGCCCGAATTAACTGGCAAACAATGGCAGGGTATCAGCCTGCTGCACCTGGCCACCTATACGGCGGGTGGTCTGCCGCTTCAGGTACCTGACGACGTTACAGATAAAGCGGCATTACTGCGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGTGCTAAACGCCTGTATGCTAACTCCAGTATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGAATGGGCTATGAAGAGGCGATGACCAAACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAGGATTATGCCTGGGGTTATCGCGAAGGGAAGCCCGTACACGTATCTCCGGGCCAGCTTGATGCCGAAGCCTACGGGGTGAAATCCAGCCTTGTCGATATGACTCGTTGGATTCAGGCCAACATGGACGCCAGCCAGGTGCAGGAGAAAACGCTCCGACAGGGAATTGAAATTGCGCAGGCTCGTTACTGGCATATTGGCGATATGTACCAGGGATTAGGTTGGGAGATGCTGAACTGGCCGGTGAATGCCGACTCGATAATCAACGGTAGCGACAGTAAAGTCGCACTAGCGGCGCTTCCCGCCGTTGAGGTCAATCCGCCCGCCCCTGCAGTGAAAGCCTCATGGGTGCACAAAACCGGCTCCACTGGCGGATTTGGCAGCTACGTTGCGTTCGTTCCGGAAAAAAATCTCGGCATCGTGATGCTGGCAAACAAAAGCTACCCAAACCCTGCTCGCGTCGAGGCCGCCTGGCGCATCTAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.16}, "gnl|BL_ORD_ID|1395|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-27", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1484", "ARO_accession": "3001847", "ARO_name": "ACT-27", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.71336e-105, "max_identities": 151, "bit_score": 310.842, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCAGAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1190|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1265", "ARO_accession": "3002167", "ARO_name": "MIR-4", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.93726e-105, "max_identities": 153, "bit_score": 309.301, "cvterm_id": "35914", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP F     +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAPMFE--KQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTTCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTAGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.4}, "gnl|BL_ORD_ID|621|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-36", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "663", "ARO_accession": "3003171", "ARO_name": "ACT-36", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.4106e-104, "max_identities": 152, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGALT   +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALTVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALTVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGACGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCTGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.72}, "gnl|BL_ORD_ID|1044|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1114", "ARO_accession": "3001838", "ARO_name": "ACT-17", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45734e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGATGGTAAAGCGGTGCGTGTTTCGCCGGGTATGCTAGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1966|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-33", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2135", "ARO_accession": "3001853", "ARO_name": "ACT-33", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.67844e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCACATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1798|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1904", "ARO_accession": "3001852", "ARO_name": "ACT-32", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.81108e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|5|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-35", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "9", "ARO_accession": "3001855", "ARO_name": "ACT-35", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.99713e-104, "max_identities": 146, "bit_score": 308.145, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYYILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTGTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACTATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1853|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1959", "ARO_accession": "3001830", "ARO_name": "ACT-7", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08429e-104, "max_identities": 145, "bit_score": 307.76, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "M+KSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAGAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCACATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|1362|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1451", "ARO_accession": "3003173", "ARO_name": "MIR-17", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15204e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVTSAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAGTAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|1784|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1888", "ARO_accession": "3002175", "ARO_name": "MIR-10", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.25648e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|595|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "638", "ARO_accession": "3001827", "ARO_name": "ACT-16", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.33127e-104, "max_identities": 146, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILEAL", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|370|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "399", "ARO_accession": "3002181", "ARO_name": "MIR-16", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.47584e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACATGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCTCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|208|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "224", "ARO_accession": "3002168", "ARO_name": "MIR-2", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.51381e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAACACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|658|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "700", "ARO_accession": "3001851", "ARO_name": "ACT-31", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.7505e-104, "max_identities": 146, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACAGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTTCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTACCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|401|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "433", "ARO_accession": "3001845", "ARO_name": "ACT-25", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.00314e-104, "max_identities": 146, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILKALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACAGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCATTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACTGGCGGATTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCAAGGCGCTTCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1471|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1565", "ARO_accession": "3001839", "ARO_name": "ACT-18", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.22662e-104, "max_identities": 151, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTATACGTTTGGCAAAGCCGATATCGCGGCTAATAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|2450|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3557", "ARO_accession": "3004745", "ARO_name": "MIR-23", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.61042e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQASSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTTCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|627|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "669", "ARO_accession": "3002177", "ARO_name": "MIR-12", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.92098e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAGTAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACATGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1772|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1875", "ARO_accession": "3002176", "ARO_name": "MIR-11", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.13955e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGAGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAACAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1233|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1309", "ARO_accession": "3001841", "ARO_name": "ACT-20", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.60625e-104, "max_identities": 145, "bit_score": 306.99, "cvterm_id": "39098", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTCGGTAAAGCCGATGTTGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|346|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "373", "ARO_accession": "3002169", "ARO_name": "MIR-3", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1977e-104, "max_identities": 152, "bit_score": 306.99, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|1449|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1541", "ARO_accession": "3001836", "ARO_name": "ACT-14", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.35581e-104, "max_identities": 150, "bit_score": 306.99, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYLAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCAGATATCGCGGCTAATAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTAACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACTTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.97}, "gnl|BL_ORD_ID|537|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "576", "ARO_accession": "3002170", "ARO_name": "MIR-5", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.85127e-104, "max_identities": 152, "bit_score": 306.605, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1550|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1645", "ARO_accession": "3001828", "ARO_name": "ACT-23", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.75672e-104, "max_identities": 150, "bit_score": 306.605, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMVPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMVPEKVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTAACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGTGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.97}, "gnl|BL_ORD_ID|1821|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-24", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1929", "ARO_accession": "3001844", "ARO_name": "ACT-24", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12367e-103, "max_identities": 151, "bit_score": 306.22, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIDGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTATACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGACGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1545|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1640", "ARO_accession": "3002179", "ARO_name": "MIR-14", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12367e-103, "max_identities": 149, "bit_score": 306.22, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +L+LATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T RI  PL L+HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIHMLELATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRIFKPLNLNHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIHMLELATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRIFKPLNLNHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDSSLRKGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPLVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTTGCCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGCATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCAAACAAACCCGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTGGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTCGGCGATCCGGTGACAAAATACTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGCATTCACATGCTGGAGCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGAATCTTTAAGCCGCTCAATCTGAACCATACCTGGATTAACGTTCCGAAAACGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTCCACGTTTCGCCAGGAATGCTGGATGCAGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAAGGGTTAGGTTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGCAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCACCGCTGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCAACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAACAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCTGCCCGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.09}, "gnl|BL_ORD_ID|1161|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1234", "ARO_accession": "3002178", "ARO_name": "MIR-13", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33699e-103, "max_identities": 151, "bit_score": 306.22, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG L+AE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLNAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLNAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTTGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGAACGCAGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|1736|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1838", "ARO_accession": "3001824", "ARO_name": "ACT-5", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44263e-103, "max_identities": 149, "bit_score": 306.22, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMP+EQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YG+K+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYPILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCCCTTTGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCATGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAATATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCCTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.6}, "gnl|BL_ORD_ID|906|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "968", "ARO_accession": "3002180", "ARO_name": "MIR-15", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.75419e-103, "max_identities": 151, "bit_score": 305.834, "cvterm_id": "39773", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PL+  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLINAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLINAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATAAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTACACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.63}, "gnl|BL_ORD_ID|224|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "241", "ARO_accession": "3001850", "ARO_name": "ACT-30", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8123e-103, "max_identities": 146, "bit_score": 305.834, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMIAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYARGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMIAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYARGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQVGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGATAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCAGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCATGGGTCCATAAAACGGGTTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGGTCGGTATTGTAATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1605|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1702", "ARO_accession": "3002166", "ARO_name": "MIR-1", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.5937e-103, "max_identities": 151, "bit_score": 305.449, "cvterm_id": "35915", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ +A+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTTCGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|891|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "951", "ARO_accession": "3001837", "ARO_name": "ACT-15", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.95483e-103, "max_identities": 145, "bit_score": 305.449, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  K G  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKSGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKSGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATTTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGTCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGTGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|1799|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1905", "ARO_accession": "3001842", "ARO_name": "ACT-21", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.18827e-103, "max_identities": 148, "bit_score": 305.064, "cvterm_id": "39098", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMP+EQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YG+K+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADVAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADVAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYPILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTCGGTAAAGCCGATGTTGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCCCTTTGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCATGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAATATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCCTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.22}, "gnl|BL_ORD_ID|1098|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1164", "ARO_accession": "3002174", "ARO_name": "MIR-9", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.2231e-103, "max_identities": 151, "bit_score": 305.064, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+ I +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQSIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQSIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGAGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGTTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCACCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTTGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|17|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "22", "ARO_accession": "3001832", "ARO_name": "ACT-10", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.3703e-103, "max_identities": 147, "bit_score": 304.679, "cvterm_id": "36783", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKS+   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPG+AVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QWKGI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MKKSVCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGIAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWKGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPD", "sequence_from_broadstreet": "MMKKSVCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGIAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWKGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLEDSSLRKGFTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCGTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATAGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAATAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGAAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAACGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTGAGGATAGTTCACTCAGGAAAGGCTTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGTTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCGTTTATTCCCGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|70|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-29", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "80", "ARO_accession": "3001849", "ARO_name": "ACT-29", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.45943e-103, "max_identities": 147, "bit_score": 304.294, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKSL   L+  ++    +AP   +   +A +V+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MKKSLCCALLLSTSCSVLAAP--MSEKQLAEMVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPD", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCSVLAAPMSEKQLAEMVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLQDSSLRKGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCAGCACATCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGATGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTCGCGGCGAATAAACCTGTCACTCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGTATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCCAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAATATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGTTGCCTGCGAGAGAAGTGAATCCACCGGCTCCCCCGGTCAATGCGTCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCCGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|238|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-37", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "257", "ARO_accession": "3003172", "ARO_name": "ACT-37", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.12279e-103, "max_identities": 151, "bit_score": 304.294, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKS    L   LLA S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI AK+PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  KY PEL   QW+GI +LDLATYTAGGLPLQVP+ V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L+HT+I VP++  + YA+GY++ K V VSPG LDAE+YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSFCCAL---LLAISGAALAAPVSEKQLAEVVANTVTPLMKAQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVIKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSFCCALLLAISGAALAAPVSEKQLAEVVANTVTPLMKAQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVIKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEAKTVIEGSDNKVALAPLPVAEVNPPVPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCTTTTGCTGCGCCCTGCTGCTCGCCATCTCTGGCGCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGGCTATTCCAGGCATGGCGGTGGCCGTTATCTATCAGGGAAAACCGCACTATTACACGTTTGGCGAAGCCGATATTGCGGCCAAAAAACCCGTTACGCCACAAACCCTGTTCGAGCTAGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGATGATCCGGTGATCAAATACTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCAACCTACACCGCGGGCGGCCTGCCGCTACAGGTACCGGAAGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAACACTGGCAACCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAATGCCAGCATCGGACTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCGCTATGAGCAGGCCATGACGAAGCGGGTCTTCAAGCCGCTCAGGCTGAACCATACCTGGATTAACGTTCCGAAAGCGGAAGCGGCGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTCCACGTTTCACCGGGTATGCTGGACGCAGAGGCCTATGGCGTGAAAACTAACGTGCAGGATATGGCGAACTGGGTGATGGCGAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTCAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGCCTGGGCTGGGAAATGCTCAACTGGCCCGTGGAGGCCAAAACAGTGATCGAGGGCAGCGACAATAAGGTGGCACTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGTTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCACTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1794|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1900", "ARO_accession": "3001835", "ARO_name": "ACT-13", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09987e-102, "max_identities": 147, "bit_score": 303.908, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKP", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLEESSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCAGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTCTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTGAGGAAAGTTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTGGGCTGGGAAATGCTTAACTGGCCGGTCGATGCAAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.32}, "gnl|BL_ORD_ID|1689|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1788", "ARO_accession": "3001825", "ARO_name": "ACT-6", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09987e-102, "max_identities": 147, "bit_score": 303.908, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTCGCGGCGAATAAACCCGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGTGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCACTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAAGGAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGATTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|1071|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1136", "ARO_accession": "3002171", "ARO_name": "MIR-6", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30862e-102, "max_identities": 151, "bit_score": 303.523, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKT TGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSAAFAAP--MSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTSTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTSTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCGCTGCATTCGCCGCACCGATGTCCGAAACACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTCCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGCTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|625|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "667", "ARO_accession": "3001821", "ARO_name": "ACT-1", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.32708e-102, "max_identities": 146, "bit_score": 303.138, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD VK  A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCAAGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCAGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.73}, "gnl|BL_ORD_ID|220|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "236", "ARO_accession": "3001840", "ARO_name": "ACT-19", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05303e-102, "max_identities": 149, "bit_score": 302.753, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKS    L   LLA S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI AK+PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  K+ PEL   QW+GI +LDLATYTAGGLPLQVP+ V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L+HT+I VP++  + YA+GY++ K V +SPG LDAE+YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSFCCAL---LLAISGSALAAPVSEKQLAEVVANTVTPLMKTQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTKFWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHISPGMLDAEAYGVKTNVQDMANWVMANMAPENIADA", "sequence_from_broadstreet": "MMKKSFCCALLLAISGSALAAPVSEKQLAEVVANTVTPLMKTQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTKFWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHISPGMLDAEAYGVKTNVQDMANWVMANMAPENIADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEAKMVIEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCTTTTGCTGCGCCCTGCTGCTCGCCATCTCTGGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAACCCAGGCTATTCCAGGCATGGCGGTGGCCGTTATCTATCAGGGAAAACCGCACTATTACACGTTTGGCGAAGCCGATATTGCGGCCAAAAAACCTGTTACGCCACAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCCCTGGACGATCCGGTGACCAAATTCTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCAACCTACACCGCGGGCGGCCTGCCGCTACAGGTACCGGAAGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAACACTGGCAACCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAATGCCAGCATCGGACTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCGCTATGAGCAGGCCATGACGAAGCGGGTCTTCAAGCCGCTCAGGCTGAACCATACCTGGATTAACGTTCCGAAAGCGGAAGCGGCGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTCCACATTTCACCGGGTATGCTGGACGCAGAGGCCTATGGCGTGAAAACTAACGTGCAGGATATGGCGAACTGGGTGATGGCGAACATGGCGCCGGAGAACATTGCTGATGCCTCACTCAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGCATCGGGTCAATGTATCAGGGCCTGGGCTGGGAAATGCTCAACTGGCCCGTGGAGGCCAAAATGGTGATCGAGGGCAGCGACAATAAGGTGGCACTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACAGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCACTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.6}, "gnl|BL_ORD_ID|1416|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1506", "ARO_accession": "3001834", "ARO_name": "ACT-12", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.18859e-102, "max_identities": 148, "bit_score": 302.753, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  ++  A +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+G+ +LDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFGAL    +GM +EQ +T R+L PL L+HT+I VP++ +  YA+GY++ K V VSPG LDAE+YGVK+  KDM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLSTSCAALAAP--LSETQLAKVVERTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDA", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCAALAAPLSETQLAKVVERTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDASLKQGMVLAQSRYWRTGSMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTGTGCTGCGCCCTGCTGCTCAGCACCTCCTGCGCTGCATTAGCCGCACCTCTGTCAGAAACACAGCTGGCGAAGGTCGTGGAACGTACCGTTACGCCCCTGATGAAAGCGCAGTCTATTCCGGGTATGGCGGTCGCCGTGATCTATCAGGGCCAGCCGCACTACTTCACCTTCGGCAAGGCCGATGTCGCCGCGAACACACCCGTCACTGCACAAACGCTGTTTGAGCTGGGCTCAATCAGCAAAACCTTCACCGGCGTTCTGGGTGGCGATGCTATTGCTCGCGGTGAAATTTCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAACTGACCGGCAAACAGTGGCAGGGCGTTCGCATGCTGGACCTGGCAACCTATACTGCCGGTGGCCTGCCGTTACAGGTGCCCGATGAGGTTACCGATAATGCCTCGCTGCTGCGTTTTTACCAGTCCTGGCAACCACAGTGGGCGCCAGGCACCACGCGTCTTTATGCGAATGCCAGCATCGGTCTGTTTGGGGCTCTGGCAGTGAAACCTTCTGGCATGCGCTTTGAGCAGGCGATGACGGAGCGGGTCCTGAAGCCGCTTAACCTGAACCATACGTGGATTAACGTTCCGAAGGCAGAAGAACAGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTTCACGTTTCGCCGGGCATGCTCGATGCCGAAGCATATGGCGTGAAAACCAACGTGAAGGATATGGCGAGCTGGGTGGTGGCTAACATGGCCCCCGATGGGGTACAGGATGCCTCACTGAAGCAGGGCATGGTGCTTGCACAGTCTCGCTACTGGCGCACAGGCTCGATGTACCAGGGCCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTGGTGGAGGGCAGCGACAACAAGGTAGCGCTTGCACCGTTGCCCGTGGCAGAAGTGAACCCTCCGGCTCCACCGGTAAAAGCGTCATGGGTACATAAAACAGGCTCGACGGGCGGATTTGGCAGCTACGTGGCATTTATCCCTGAGAAGGAACTCGGCATCGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCACGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.43}, "gnl|BL_ORD_ID|1406|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1495", "ARO_accession": "3001829", "ARO_name": "ACT-4", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.75704e-102, "max_identities": 146, "bit_score": 302.368, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGCCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTTACCGGCGTACTGGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACGGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCGCGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCCAATACCAGCATCGGCCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAACAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGCAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTAGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCCGCAAGAGAAGTGAATCCTCCGGCGCCTCCGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCAGCACGCGTTGAGGCGGCTTACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.73}, "gnl|BL_ORD_ID|2135|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3313", "ARO_accession": "3001831", "ARO_name": "ACT-8", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.18325e-102, "max_identities": 146, "bit_score": 302.368, "cvterm_id": "35914", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ +S YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEESHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMVNMKP", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEESHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMVNMKPDSLQDSSLRKGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAATAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAACTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACTACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCCAAAGCGGAAGAGTCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTAGGTGCCATGTATCAGGGTTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCGTTTATTCCCGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.94}, "gnl|BL_ORD_ID|372|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "401", "ARO_accession": "3001843", "ARO_name": "ACT-22", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.60185e-102, "max_identities": 148, "bit_score": 301.597, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  ++  A +AP   +   +A VV  T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  KY PEL   QW+G+ +LDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFGAL    +GM +EQ +T R+L PL L+HT+I VP++ +  YA+GY++ K V VSPG LDAE+YGVK+  KDM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLSTSCAALAAP--MSETQLAKVVARTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLSDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDA", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCAALAAPMSETQLAKVVARTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLSDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDASLKQGMALAQSRYWRTGSMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKKLGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTGTGCTGCGCCCTGCTGCTCAGCACCTCCTGCGCTGCATTAGCCGCACCTATGTCAGAAACACAGCTGGCGAAGGTCGTGGCACGTACCGTTACGCCCCTGATGAAAGCGCAGTCTATTCCGGGTATGGCGGTCGCCGTGATCTATCAGGGCCAGCCGCACTACTTCACCTTCGGCAAGGCCGATGTCGCAGCGAACACACCCGTCACTGCACAAACGCTGTTTGAGCTGGGCTCAATCAGCAAAACCTTCACCGGCGTTCTGGGTGGCGATGCTATTGCTCGCGGTGAAATTTCGCTGAGCGATCCGGTGACCAAATACTGGCCTGAGCTGACCGGCAAACAGTGGCAGGGCGTTCGCATGCTGGACCTGGCAACCTATACTGCCGGTGGCCTGCCGTTACAGGTGCCCGATGAGGTTACCGATAATGCCTCGCTGCTGCGTTTTTACCAGTCCTGGCAACCACAGTGGGCGCCAGGCACCACGCGTCTTTATGCGAATGCCAGCATCGGTCTGTTTGGGGCTCTGGCGGTGAAACCTTCTGGCATGCGCTTTGAGCAGGCGATGACAGAGCGGGTCCTGAAGCCGCTTAACCTGAACCATACGTGGATTAACGTTCCGAAGGCAGAAGAACAGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTTCACGTTTCGCCGGGCATGCTCGATGCCGAAGCGTATGGCGTGAAAACCAACGTGAAGGATATGGCGAGCTGGGTAGTGGCTAACATGGCCCCCGATGGCGTACAGGATGCCTCACTGAAGCAGGGCATGGCGCTTGCACAGTCTCGCTACTGGCGCACAGGCTCGATGTACCAGGGCCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTGGTGGAGGGCAGCGACAACAAAGTAGCGCTTGCGCCGTTGCCCGTGGCAGAAGTGAACCCTCCTGCTCCACCGGTAAAAGCGTCATGGGTACATAAAACAGGCTCGACGGGCGGATTTGGCAGCTACGTGGCATTTATCCCTGAGAAGAAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.43}, "gnl|BL_ORD_ID|2109|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-38", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3311", "ARO_accession": "3003655", "ARO_name": "ACT-38", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.38235e-102, "max_identities": 147, "bit_score": 301.597, "cvterm_id": "36915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANNPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWLGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITMRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANNPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWLGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITMRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAACCCTGTCACCCCACAAACCTTATTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCTGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGTGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTATGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGATGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAAGGAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGATTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|2700|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMH-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3576", "ARO_accession": "3004777", "ARO_name": "CMH-1", "ARO_category": {"42891": {"category_aro_accession": "3004776", "category_aro_cvterm_id": "42891", "category_aro_name": "CMH beta-lactamase", "category_aro_description": "CMH is a class C beta-lactamase gene family belonging to Enterobacter cloacae.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.94671e-102, "max_identities": 151, "bit_score": 301.597, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+   A  AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGSVSKTFTGVLG  ++A+KE++L DP  KY PEL   QW+GI LLDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFG+L    +GM +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  KDM  W   NM P ", "sequence_from_db": "MTKSLSCALLLSVACSAFAAP--MSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPE", "sequence_from_broadstreet": "MMTKSLSCALLLSVACSAFAAPMSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPETLPQSTLQQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVDGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPVRVETAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGCGCGCTGCTGCTCAGCGTTGCCTGCTCTGCTTTTGCCGCGCCGATGTCAGAAAAACAGCTGGCTGACGTCGTGGAACGTACCGTTACGCCTCTGATGAAGGCGCAGGCCATACCCGGAATGGCCGTGGCCGTCATTTATCAGGGCCAGCCACACTATTTTACTTTCGGTAAAGCAGACGTCGCGGCGAATAAGCCCGTCACGCCGCAAACCTTATTTGAGCTGGGCTCCGTCAGCAAAACCTTCACCGGCGTGCTGGGTGGCGATGCCATTGCCCGCAAAGAGATTTCGCTGGCCGACCCGGTCACGAAATATTGGCCTGAATTGACGGGCAAGCAGTGGCAAGGCATTCGCCTGCTAGACCTGGCAACCTATACCGCAGGCGGATTGCCGTTGCAGGTACCGGATGATGTCACCGATAACGCCTCTCTGCTGCGTTTCTACCAGTCCTGGCAGCCAAAGTGGGCCCCGGGTACCACGCGTCTGTACGCCAACACCAGCATCGGTTTGTTTGGCTCACTGGCCGTTAAACCGTCCGGCATGTGCTTCGAGCAGGCCATGGCGGAGCGGGTCTTTAAGCCCCTGAAACTCAACCATACGTGGATAAACGTTCCACACGCTGAAGAACCGCACTACGCATGGGGTTATCGTGAGGGAAAAGCGGTCCACGTTTCGCCTGGTATGCTGGATGCAGAAGCCTATGGCGTGAAATCTAACGTCAAAGATATGGCGAGTTGGGTGATGGCCAATATGGCACCTGAGACACTCCCGCAGTCCACTCTGCAGCAGGGTATTGCGCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAAGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTGGTGGATGGCAGCGATAATAAGGTCGCACTGGCGCCGTTGCCGGTCGCAGAAGTGAATCCTCCGGCTCCGCCAGTAAAAGCCTCCTGGGTGCATAAAACGGGCTCTACGGGTGGGTTTGGCAGCTACGTGGCGTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCAAATAAAAGCTATCCGAACCCGGTACGGGTGGAAACGGCTTACCGTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.63}, "gnl|BL_ORD_ID|2582|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CFE-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2901", "ARO_accession": "3004464", "ARO_name": "CFE-2", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12384e-101, "max_identities": 149, "bit_score": 301.212, "cvterm_id": "36915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L+  ++L  F+A        +A +V+ TI PLM +Q IPGM  A+  +GKPYYF +G ADI   +PVT  TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y P+L   QW GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYAN SIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA GY+  +PV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCALLVTASLSTFAAD--KTEQQIADIVNRTITPLMQEQAIPGMRFAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPKLTGKQWLGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANPSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYALGYREGRPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLVTASLSTFAADKTEQQIADIVNRTITPLMQEQAIPGMRFAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPKLTGKQWLGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANPSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYALGYREGRPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQVQEKTLRQGIEIAQARYWHIGDMYQGLGWEMVNWPVNADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGTSGGFGTYVALVPEKNLVGMMLANKSYPKPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATTTGCTGCGCGTTGCTGGTCACAGCCTCTCTGTCAACGTTTGCCGCCGACAAAACAGAACAACAGATTGCCGATATCGTAAACCGTACCATCACACCGCTGATGCAAGAACAGGCTATTCCGGGTATGCGCTTCGCAATTATCTACCAGGGAAAACCCTATTACTTTACCTGGGGGAAAGCCGATATCGCCAATGACCGCCCCGTCACCCGGCAAACGCTGTTTGAGCTTGGATCGGTAAGTAAGACGTTTAACGGTGTGCTGGGCGGCGATGCTATCGCCCGTGGTGAAATTAAGCTCAGCGATCCGGTCACCCAATACTGGCCCAAATTAACTGGCAAACAATGGCTGGGTATCAGCCTGCTGCATCTGGCCACCTATACGGCGGGTGGCCTGCCGCTTCAGGTACCTGACGACGTTACAGATAAAGCGGCATTACTGCGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAACGCCTGTATGCTAACCCAAGTATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGAATGGGCTATGAAGAGGCGATGACCAAACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAGGATTATGCCTTGGGTTATCGCGAAGGAAGGCCCGTGCACGTATCTCCGGGCCAGCTTGATGCCGAAGCCTACGGGGTGAAATCCAGCCTTGTCGATATGACTCGCTGGATTCAGGCCAACATGGACGCCAGCCAGGTGCAGGAGAAAACGCTCCGACAGGGAATTGAAATTGCGCAGGCTCGTTACTGGCATATTGGCGATATGTACCAGGGATTAGGTTGGGAGATGGTCAACTGGCCGGTGAATGCCGACTCGATAATCAACGGTAGCGACAGTAAAGTCGCGTTAGCGGCGCTTCCCGCCGTTGAGGTCAATCCGCCCGCCCCTGCAGTGAAAGCCTCATGGGTGCACAAAACCGGCACTTCCGGCGGATTTGGCACGTACGTTGCGTTGGTTCCGGAAAAAAATCTCGTCGGCATGATGCTGGCAAACAAAAGCTACCCAAAGCCTGCTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAATTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.65}, "gnl|BL_ORD_ID|492|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "526", "ARO_accession": "3001822", "ARO_name": "ACT-2", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.67957e-101, "max_identities": 145, "bit_score": 300.827, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.34}, "gnl|BL_ORD_ID|1485|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1581", "ARO_accession": "3001823", "ARO_name": "ACT-3", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.53748e-101, "max_identities": 144, "bit_score": 300.442, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAGCGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGATACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAATGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.96}, "gnl|BL_ORD_ID|2508|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "BUT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2846", "ARO_accession": "3004294", "ARO_name": "BUT-1", "ARO_category": {"41459": {"category_aro_accession": "3004293", "category_aro_cvterm_id": "41459", "category_aro_name": "BUT beta-lactamase", "category_aro_description": "A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.83006e-101, "max_identities": 150, "bit_score": 300.442, "cvterm_id": "41461", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTS", "match": "MKK+L   L+  ++  AF+A    +   +   V+ T+KP++  Q IPGMAVAV  +GKP+YF YG ADI   QPVT  T+FELGSVSKTFTGVLG   VA+ E+ L+DPA KY PEL   QW+GITLLDLATYTAGGLPLQVPD V ++A LL FYQ WQP   PG  R YANSSIGLFGAL    +GM +   +  R+L PL L HT++TVP S ++ YA+GY++ K + V PG LD E+YGVKS  +DM  W + NM P +      L   LE++ S", "sequence_from_db": "MKKTLCCALVLSASFSAFAAQKTLSDKQLEEAVNQTLKPMITAQAIPGMAVAVIYQGKPHYFTYGVADIAKNQPVTTQTIFELGSVSKTFTGVLGGDIVARGEVKLSDPAMKYWPELTGKQWQGITLLDLATYTAGGLPLQVPDEVDNQAALLKFYQNWQPDWAPGTRRQYANSSIGLFGALAVKPSGMTFNDAMRQRVLQPLNLKHTWLTVPASEENHYAWGYRDGKAMHVGPGMLDTEAYGVKSTIEDMASWVQYNMNPQQVKQP-TLQKGLEIAQS", "sequence_from_broadstreet": "MCRTLCHVTYGRFSMMKKTLCCALVLSASFSAFAAQKTLSDKQLEEAVNQTLKPMITAQAIPGMAVAVIYQGKPHYFTYGVADIAKNQPVTTQTIFELGSVSKTFTGVLGGDIVARGEVKLSDPAMKYWPELTGKQWQGITLLDLATYTAGGLPLQVPDEVDNQAALLKFYQNWQPDWAPGTRRQYANSSIGLFGALAVKPSGMTFNDAMRQRVLQPLNLKHTWLTVPASEENHYAWGYRDGKAMHVGPGMLDTEAYGVKSTIEDMASWVQYNMNPQQVKQPTLQKGLEIAQSRYWRSGSMYQGLGWEMLNWPVAAATVINGSDNKVALAASPVTAIEPPVAPVKASLVHKTGSTNGFGAYVAFIPEKQIGIVMLANKMYPNTERVKAANTLLNTLQ", "dna_sequence_from_broadstreet": "ATGTGCCGGACCCTCTGTCATGTTACTTATGGAAGATTTTCAATGATGAAAAAAACACTCTGCTGCGCGCTGGTTCTGAGCGCCTCTTTCTCCGCCTTTGCTGCACAAAAAACATTGAGTGACAAACAGTTAGAAGAGGCTGTCAATCAAACGCTTAAACCGATGATTACAGCCCAGGCCATTCCCGGCATGGCGGTGGCGGTGATTTATCAGGGCAAGCCGCACTACTTTACCTACGGCGTGGCCGACATCGCGAAAAATCAGCCGGTGACGACACAGACGATTTTTGAGCTGGGCTCCGTGAGTAAAACTTTCACCGGCGTGCTGGGCGGCGATATCGTGGCGCGCGGGGAAGTGAAGCTGAGTGACCCGGCGATGAAATACTGGCCAGAACTGACGGGCAAGCAGTGGCAGGGCATCACGTTGCTGGATCTGGCGACCTACACCGCCGGCGGCTTGCCGTTGCAGGTGCCGGATGAGGTCGATAATCAGGCCGCGCTGCTGAAGTTTTACCAGAACTGGCAGCCGGACTGGGCGCCGGGAACCCGTCGTCAGTACGCCAACTCGAGCATTGGCCTGTTTGGTGCGTTGGCAGTGAAACCGTCCGGGATGACGTTTAACGATGCGATGCGCCAGCGCGTTCTGCAACCGCTGAACCTGAAACATACCTGGCTCACCGTTCCGGCCAGTGAAGAAAATCATTACGCCTGGGGCTATCGTGACGGCAAAGCCATGCACGTCGGGCCGGGCATGCTGGATACCGAAGCCTACGGTGTCAAATCCACCATCGAAGATATGGCGAGCTGGGTGCAATACAACATGAACCCGCAGCAGGTGAAACAGCCGACGCTGCAAAAAGGGCTGGAGATTGCGCAGTCGCGCTACTGGCGCAGCGGCAGTATGTATCAGGGCTTAGGCTGGGAAATGCTGAACTGGCCGGTTGCGGCGGCGACCGTCATTAACGGCAGCGATAACAAAGTGGCGCTGGCGGCTTCGCCCGTGACGGCCATTGAACCGCCGGTTGCGCCGGTGAAAGCTTCTCTGGTGCATAAAACCGGGTCGACCAACGGCTTCGGCGCGTACGTGGCGTTCATTCCTGAAAAACAAATCGGCATCGTGATGCTGGCTAACAAAATGTATCCGAATACCGAGCGGGTTAAAGCGGCAAATACTCTTCTCAACACGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2676, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 53.76}, "gnl|BL_ORD_ID|1603|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-28", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1700", "ARO_accession": "3001848", "ARO_name": "ACT-28", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.76977e-99, "max_identities": 142, "bit_score": 295.819, "cvterm_id": "36884", "query": "SATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "+ +L  ALL  ++    AA      ++ VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM +EQ +T R+  PL L HT+I VP+  ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W + NM P ", "sequence_from_db": "TKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQHWQPQWKPGATRLYANASIGLFGALAVKPSGMSFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPD", "sequence_from_broadstreet": "MKTKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQHWQPQWKPGATRLYANASIGLFGALAVKPSGMSFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPDALPDSTLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGAAGACAAAATCCCTTTGCTGTGCCCTGCTGCTCAGCACCTCCTGCTCTGTTCTCGCCGCGCCGATGTCAGAGAAACAGCTGTCTGACGTGGTGGAACGTACCGTTACCCCCCTGATGAAAGCGCAAGCCATTCCGGGCATGGCGGTAGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGAAAGGCCGATGTTGCGGCGAACAAACCTGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTATTAGGTGGCGATGCGATTGCGCGCGGAGAAATATCGCTGGGCGACCCCGTGACAAAGTACTGGCCCGAGCTAACAGGCAAGCAGTGGCAGGGTATTCGCATGTTGGATCTGGCGACCTACACCGCGGGTGGCCTGCCGCTACAGGTGCCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGTTTCTATCAACACTGGCAACCGCAGTGGAAACCAGGCGCAACGCGTCTTTATGCGAACGCCAGCATCGGGCTTTTTGGCGCCCTCGCGGTTAAACCCTCCGGCATGAGCTTTGAACAGGCCATGACGAAGCGGGTCTTCAAGCCACTCAAACTGGACCATACATGGATTAACGTTCCGAAAGAAGAAGAGGCGCATTACGCCTGGGGATACCGTGATGGTAAAGCAATCCACGTTTCACCGGGAATGCTGGATGCCGAAGCGTATGGTGTCAAAACCAACATCCAGGATATGGCGAGCTGGCTGAAGGCCAACATGAACCCTGACGCCCTTCCGGATTCAACGTTGAAACAGGGTATTGCCCTGGCACAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTCGTGGAGGGCAGCGATAACAAGGTGGCTCTTGCACCGTTACCGGTGGCAGAAGTGAACCCTCCAGCTCCGCCAGTAAAAGCATCATGGGTACATAAAACAGGCTCGACGGGTGGATTCGGCAGCTATGTCGCATTTATTCCTGAAAAGGAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1861, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.83}, "gnl|BL_ORD_ID|1089|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1155", "ARO_accession": "3001826", "ARO_name": "ACT-9", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.78868e-99, "max_identities": 141, "bit_score": 294.664, "cvterm_id": "36950", "query": "SATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "+ +L  ALL  ++    AA      ++ VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V     LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM +EQ +T R+  PL L HT+I VP+  ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W + NM P ", "sequence_from_db": "TKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVTANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNTSLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMNFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPD", "sequence_from_broadstreet": "MKTKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVTANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNTSLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMNFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPDALSDSTLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLLVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGAAGACAAAATCCCTTTGCTGTGCCCTGCTGCTCAGCACCTCCTGCTCTGTTCTCGCCGCGCCGATGTCAGAGAAACAGCTGTCTGACGTGGTGGAACGTACCGTTACCCCCCTGATGAAAGCGCAAGCCATTCCGGGCATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGAAAGGCCGATGTTACGGCGAACAAACCTGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTATTAGGTGGCGATGCGATTGCGCGCGGAGAAATATCGCTGGGCGACCCCGTGACAAAGTACTGGCCCGAGCTAACAGGCAAGCAGTGGCAGGGTATTCGCATGTTGGATCTGGCGACCTACACCGCGGGTGGCCTGCCGCTACAGGTGCCGGATGAGGTCACGGATAACACCTCCCTGCTGCGTTTCTATCAACACTGGCAACCGCAGTGGAAACCAGGCACAACGCGTCTTTATGCGAACGCCAGCATCGGGCTTTTTGGCGCCCTCGCGGTTAAACCCTCCGGTATGAACTTTGAACAGGCCATGACGAAGCGGGTCTTCAAGCCACTCAAACTGGACCATACATGGATTAACGTTCCGAAAGAAGAAGAGGCGCATTACGCCTGGGGATACCGTGATGGTAAAGCAATCCACGTTTCACCGGGAATGCTGGATGCCGAAGCGTATGGTGTCAAAACCAACATCCAGGATATGGCGAGCTGGCTGAAGGCCAACATGAACCCTGACGCCCTTTCGGATTCAACGTTGAAACAGGGTATTGCCCTGGCACAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTCGTGGAGGGCAGCGATAACAAGGTGGCTCTTGCACCGTTACTGGTGGCAGAAGTGAACCCTCCAGCTCCGCCAGTAAAAGCATCATGGGTACATAAAACAGGCTCGACGGGTGGATTCGGCAGCTATGTCGCATTTATTCCTGAAAAGGAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTTTGAGCGCTCTGTAG", "partial": "0", "query_start": 1861, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.44}, "gnl|BL_ORD_ID|2047|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1", "ARO_accession": "3002501", "ARO_name": "PDC-4", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70112e-86, "max_identities": 130, "bit_score": 261.151, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ EM L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDEMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDEMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACGAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.43}, "gnl|BL_ORD_ID|2542|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2861", "ARO_accession": "3004345", "ARO_name": "PDC-82", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.6625e-85, "max_identities": 125, "bit_score": 259.61, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ+PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+LL  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQLPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLLEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQLPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLLEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGCTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCCTGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.23}, "gnl|BL_ORD_ID|327|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "352", "ARO_accession": "3002502", "ARO_name": "PDC-5", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.6974e-85, "max_identities": 129, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCAGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|672|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "715", "ARO_accession": "3002500", "ARO_name": "PDC-3", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.12141e-85, "max_identities": 129, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|1060|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1130", "ARO_accession": "3002508", "ARO_name": "PDC-9", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.46434e-85, "max_identities": 128, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+ VA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K RA + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAVEAPADRLKALVDAAVQPVMKANDIPGLTVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDRAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAVEAPADRLKALVDAAVQPVMKANDIPGLTVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDRAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGTCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGACCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCGGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2536|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2855", "ARO_accession": "3004339", "ARO_name": "PDC-76", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.63868e-85, "max_identities": 124, "bit_score": 258.07, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGTCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCCCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|636|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "678", "ARO_accession": "3002509", "ARO_name": "PDC-10", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.47453e-85, "max_identities": 129, "bit_score": 258.84, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFAATPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFAATPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCGCCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|2533|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2852", "ARO_accession": "3004336", "ARO_name": "PDC-73", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.64094e-85, "max_identities": 124, "bit_score": 258.07, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCTGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|2541|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2860", "ARO_accession": "3004344", "ARO_name": "PDC-81", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24191e-85, "max_identities": 124, "bit_score": 257.684, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCTGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|2549|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-89", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2868", "ARO_accession": "3004352", "ARO_name": "PDC-89", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.23931e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGTCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCAATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGGCGCTGCAGCCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2552|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-92", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2871", "ARO_accession": "3004355", "ARO_name": "PDC-92", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.27692e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMAPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2550|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2869", "ARO_accession": "3004353", "ARO_name": "PDC-90", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30819e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCCGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACTCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2547|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-87", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2866", "ARO_accession": "3004350", "ARO_name": "PDC-87", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.46207e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2548|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-88", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2867", "ARO_accession": "3004351", "ARO_name": "PDC-88", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.48568e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2551|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-91", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2870", "ARO_accession": "3004354", "ARO_name": "PDC-91", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.59341e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSLQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2553|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-93", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2872", "ARO_accession": "3004356", "ARO_name": "PDC-93", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.5942e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMAPQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCCGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|1358|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1446", "ARO_accession": "3002505", "ARO_name": "PDC-6", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.68034e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCAGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|572|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "612", "ARO_accession": "3002506", "ARO_name": "PDC-7", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.79283e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGACGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|371|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "400", "ARO_accession": "3002497", "ARO_name": "PDC-1", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.85187e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36804", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2545|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-85", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2864", "ARO_accession": "3004348", "ARO_name": "PDC-85", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.65023e-84, "max_identities": 123, "bit_score": 256.529, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE +GVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCCATGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|95|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "108", "ARO_accession": "3002507", "ARO_name": "PDC-8", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.69645e-84, "max_identities": 128, "bit_score": 256.914, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  R Y+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRRYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRRYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCGCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|1038|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1107", "ARO_accession": "3002498", "ARO_name": "PDC-2", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.39363e-84, "max_identities": 128, "bit_score": 256.914, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTVTLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTVTLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGACGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGTCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2546|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-86", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2865", "ARO_accession": "3004349", "ARO_name": "PDC-86", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.39105e-84, "max_identities": 122, "bit_score": 254.988, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA+ YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCAAAGGCTACGGGGTGAAGACCAGCGCCGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACTCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.83}, "gnl|BL_ORD_ID|2535|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2854", "ARO_accession": "3004338", "ARO_name": "PDC-75", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.39105e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCCCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCATGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2544|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-84", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2863", "ARO_accession": "3004347", "ARO_name": "PDC-84", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70065e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+R  PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGCGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGCCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-83", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2862", "ARO_accession": "3004346", "ARO_name": "PDC-83", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70065e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+R  PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGCGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGCCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2534|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2853", "ARO_accession": "3004337", "ARO_name": "PDC-74", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.03508e-83, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2539|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2858", "ARO_accession": "3004342", "ARO_name": "PDC-79", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.38595e-83, "max_identities": 122, "bit_score": 254.603, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA+ YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCAAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2540|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-80", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2859", "ARO_accession": "3004343", "ARO_name": "PDC-80", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.91256e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA  YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAGGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAGGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGGAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCACTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2537|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2856", "ARO_accession": "3004340", "ARO_name": "PDC-77", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.04152e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2538|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2857", "ARO_accession": "3004341", "ARO_name": "PDC-78", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.2201e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L    + GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSHFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSHFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCACTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|494|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "528", "ARO_accession": "3002521", "ARO_name": "OCH-8", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.57476e-80, "max_identities": 116, "bit_score": 247.284, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALATSKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTACGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAACCCGATTATCCGGCAGGGACGCAGCGTCGTTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|186|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "201", "ARO_accession": "3002516", "ARO_name": "OCH-3", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.97598e-80, "max_identities": 116, "bit_score": 246.899, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A     L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFTLSDPATKWAPELADSSFDKITMLDLGTYTPGGLPLQFPDAVSDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFTLSDPATKWAPELADSSFDKITMLDLGTYTPGGLPLQFPDAVSDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYRVDANNQGLGWEFYNYPTALKTLLEGNSSDMALKSHKIEKFDTPSQPSADVWLNKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACCGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTCGGCGGCTACGGGCTGGCGACAGGCGCGTTCACTCTGTCCGATCCCGCGACCAAATGGGCCCCCGAACTGGCAGACAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCTCCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCGTGTCGATGCGAACAATCAGGGGCTTGGCTGGGAGTTCTACAACTATCCGACCGCGCTCAAGACGCTTCTTGAGGGCAACTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTAGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAACTATCCGATTGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|713|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "759", "ARO_accession": "3002515", "ARO_name": "OCH-2", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.27938e-80, "max_identities": 116, "bit_score": 246.514, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L +++ W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRTSTTLLIGFLTTAAVIPNNGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLELDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERIKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAACATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTGTTATCCCGAATAACGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACCGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTCGGCGGCTACGGGCTTGCGACCGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCCGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAACTGGAAACCCGATTACCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCTTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCATAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|1148|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1220", "ARO_accession": "3002518", "ARO_name": "OCH-5", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.53964e-80, "max_identities": 115, "bit_score": 245.358, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G    Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWRPDYPAGTQHRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGTLDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWRPDYPAGTQHRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGTLDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVDANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVVLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAACGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGCTACGGGCTGGCGACGGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAGGCCGGACTATCCGGCAGGCACGCAGCATCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGACGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATTGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACACACACGGGTTACTACCATGTCGATGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTGTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.73}, "gnl|BL_ORD_ID|1601|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1698", "ARO_accession": "3002519", "ARO_name": "OCH-6", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.38573e-79, "max_identities": 115, "bit_score": 244.588, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAATCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.73}, "gnl|BL_ORD_ID|727|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "773", "ARO_accession": "3002517", "ARO_name": "OCH-4", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52394e-78, "max_identities": 114, "bit_score": 242.276, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALATSKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTACGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGATATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|694|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "739", "ARO_accession": "3002492", "ARO_name": "LRA-18", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.705e-78, "max_identities": 121, "bit_score": 242.276, "cvterm_id": "39683", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGF", "match": "VD+ + P+MAQ D+PGMAVAV+V G+P++FNYG A   +KQPVTE T+FELGS SKTFT  L A + A+ ++AL+D   KY P+L      G TLL L TYTAGG PLQ+PD +K+R  L +++Q W+P   PG  R Y+N SIGLFG +   A G  +       +   LGL HT+I VP+SA + YA+GY   + VRV P   D+E+YGVKS + DM+R+ ++ ++PSR                 AP+R    AT  G+", "sequence_from_db": "VDAAVGPVMAQFDVPGMAVAVTVDGQPHFFNYGVAARDSKQPVTEATIFELGSNSKTFTATLAAYAQAQGKLALDDHPGKYVPQLQGSALDGATLLHLGTYTAGGFPLQIPDNLKTREQLFSYFQHWKPDAAPGKQRNYSNPSIGLFGHIAGLALGGGFADAAERDLFPQLGLQHTYIRVPQSAMAHYAWGYSKDQAVRVQPDLFDSEAYGVKSTAADMIRYVQLQIDPSRL---------------AAPMRRAVQATHTGY", "sequence_from_broadstreet": "MLKRIRLPQLALALAALFPLAAYAAPDAAALRQAVDAAVGPVMAQFDVPGMAVAVTVDGQPHFFNYGVAARDSKQPVTEATIFELGSNSKTFTATLAAYAQAQGKLALDDHPGKYVPQLQGSALDGATLLHLGTYTAGGFPLQIPDNLKTREQLFSYFQHWKPDAAPGKQRNYSNPSIGLFGHIAGLALGGGFADAAERDLFPQLGLQHTYIRVPQSAMAHYAWGYSKDQAVRVQPDLFDSEAYGVKSTAADMIRYVQLQIDPSRLAAPMRRAVQATHTGYFKAGPMTQGLGWESYPYPVSLEQLLQGNSTDMAWKPQPVQAIQPVQTAAPALYNKTGSTRGFGSYVAFVPSQKIGIVLLANRAYPNDARIKLAYAILNQLAPAAN", "dna_sequence_from_broadstreet": "ATGTTGAAACGTATCCGCTTGCCCCAACTGGCGCTGGCCCTTGCGGCGCTGTTCCCCTTGGCCGCCTACGCGGCGCCGGACGCCGCCGCGCTGCGCCAGGCCGTCGACGCGGCAGTCGGCCCCGTCATGGCGCAGTTCGATGTGCCGGGCATGGCGGTCGCCGTCACGGTCGATGGCCAGCCGCACTTTTTCAATTACGGCGTCGCCGCGCGCGACAGCAAGCAACCCGTGACGGAAGCGACCATCTTTGAGTTGGGTTCGAACAGCAAGACTTTTACGGCCACCCTGGCGGCCTATGCCCAGGCGCAAGGCAAACTGGCGCTGGACGATCACCCCGGCAAGTATGTGCCGCAATTGCAGGGCAGTGCGCTCGATGGCGCCACCTTGCTGCACCTCGGCACCTACACGGCGGGCGGCTTTCCGTTGCAAATTCCGGACAACCTGAAAACCCGGGAGCAGTTGTTCAGTTACTTTCAGCACTGGAAACCGGACGCGGCGCCGGGCAAGCAGCGTAACTATTCCAATCCCAGCATCGGCCTATTCGGCCATATTGCCGGCCTGGCGCTCGGTGGCGGCTTTGCCGACGCGGCGGAGCGCGACTTGTTCCCGCAACTGGGTTTGCAACACACTTACATCCGCGTGCCGCAGTCAGCCATGGCCCATTACGCGTGGGGCTATTCGAAAGACCAGGCGGTCCGTGTCCAGCCTGATTTGTTCGATAGTGAAGCCTATGGCGTGAAATCCACGGCGGCCGACATGATCCGCTACGTGCAACTGCAAATCGACCCGTCGCGCCTGGCCGCACCGATGCGGCGCGCGGTGCAAGCGACCCATACCGGCTACTTCAAGGCCGGCCCGATGACGCAGGGACTGGGATGGGAATCGTACCCGTATCCCGTCAGCCTGGAGCAACTGTTGCAGGGCAATTCCACCGACATGGCGTGGAAGCCGCAGCCAGTCCAGGCAATACAACCAGTGCAGACCGCGGCCCCGGCCCTGTACAACAAGACCGGTTCCACGCGGGGCTTCGGCAGCTATGTCGCCTTTGTCCCGTCGCAAAAAATTGGTATCGTGCTGCTGGCCAACCGGGCTTATCCGAACGATGCGCGGATCAAGCTGGCGTATGCGATCTTGAATCAGCTGGCCCCGGCGGCAAATTGA", "partial": "0", "query_start": 1936, "query_end": 2721, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.18}, "gnl|BL_ORD_ID|170|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "184", "ARO_accession": "3002514", "ARO_name": "OCH-1", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.85026e-78, "max_identities": 114, "bit_score": 242.276, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNSGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLEGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAGCGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACGCTTCTTGAGGGCAACTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|397|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "427", "ARO_accession": "3002520", "ARO_name": "OCH-7", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.15164e-78, "max_identities": 114, "bit_score": 241.891, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNSGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAGCGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|478|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "509", "ARO_accession": "3002155", "ARO_name": "FOX-1", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.06457e-78, "max_identities": 124, "bit_score": 241.121, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSG", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++ E NM     G+A AL T + ++ +G", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANM--GYQGDA-ALKTRIALTHTG", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCCGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGCACTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATTCAGGTGCCGGAGTCGGCCATAGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTACCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAACGCGGATCGCGCTGACCCATACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGTTGGGAGAGCTACGCCTATCCGTTGACCGAGCAGGCGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2679, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.01}, "gnl|BL_ORD_ID|1613|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "1711", "ARO_accession": "3002993", "ARO_name": "AQU-1", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.29531e-77, "max_identities": 115, "bit_score": 239.58, "cvterm_id": "39651", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV  +G+P+YFNYG A++   + V+E TLFE+GSVSKT+T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDEVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTYTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MKQTSPLSSLALSALLLSPLTQAAPADPLVGVVDEVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTYTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANINGVDDKGLQQAIALTHQGRYSVGEMTQGLGWESYPYPVSEQTLLAGNSVQVIMKANPTTAAPKEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHSILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTCGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGAGGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTAGCCGTGTTCAAAGAGGGGCAACCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCGACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAAACCTATACCGCCACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATCACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGTCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCCTGCATCACACCTATATCAATGTGCCGAAGCAGGCGATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCACGCCAGGGGTGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCAACGGGGTGGATGACAAGGGATTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCGCTACTCGGTAGGCGAGATGACCCAGGGGCTGGGCTGGGAGAGTTACCCCTATCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCGGTCCAGGTGATCATGAAGGCCAATCCGACGACGGCCGCGCCGAAGGAGATGGGGAGCCAGCGGCTCTTCAACAAGACCGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACTCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.94}, "gnl|BL_ORD_ID|2186|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3346", "ARO_accession": "3004647", "ARO_name": "AQU-2", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.03715e-77, "max_identities": 115, "bit_score": 239.195, "cvterm_id": "36810", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV  +G+P+YFNYG A++   + V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVQANI", "sequence_from_broadstreet": "MKQTSPLSLLALSALLLSPLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVQANINGVDDKGLQQAIALTHQGHYSVGGMTQGLGWESYPYPVSEQTLLAGNSAQVIMKANPTTAAPXEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHAILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTTGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGACGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTAGCCGTGTTCAAAGAGGGGCAACCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCGACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATTACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGTCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCCTGCATCACACCTATATCAATGTGCCGAAGCAGGCCATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAATCCCGGCATGCTGGCCGACGAGGCCTACGGCATCAAGACTAGCTCGGCGGATCTGCTCGCCTTCGTGCAGGCCAACATCAACGGGGTGGATGACAAGGGGTTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCACTACTCGGTAGGCGGGATGACTCAGGGGCTGGGCTGGGAGAGTTACCCCTATCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCGGCCCAGGTGATCATGAARGCCAATCCGACGACGGCCGCGCCGAAKGAGATGGGGAGCCAGCGGCTCTTCAACAAGACTGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACGCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.94}, "gnl|BL_ORD_ID|71|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "81", "ARO_accession": "3002157", "ARO_name": "FOX-3", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.6472e-77, "max_identities": 117, "bit_score": 238.81, "cvterm_id": "36788", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPG+AVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATAGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGTGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATAAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCAGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCCTGGTAAAAAGCGCAATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|1053|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1123", "ARO_accession": "3002161", "ARO_name": "FOX-8", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.94848e-77, "max_identities": 117, "bit_score": 238.81, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPG+AVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSLQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATAGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGTGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATAAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCAGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCCTGGTAAAAAGCGCAATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCCTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|1174|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1249", "ARO_accession": "3002159", "ARO_name": "FOX-5", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.81892e-77, "max_identities": 119, "bit_score": 238.424, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA   YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGGCGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGTTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAAGCCCACTATTTCAACTATGGGGTTGCCAACCGGGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACTGCGACCCTCGGTGCCTATGCCGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATCGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTACCGGAGTCGGCTATGGTGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCAGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGTTACGCCTATCCGGTGACCGAGCAGACATTGCTGGCGGGTAACGCACCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAGGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.29}, "gnl|BL_ORD_ID|543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "582", "ARO_accession": "3002160", "ARO_name": "FOX-7", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.16281e-77, "max_identities": 117, "bit_score": 238.424, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KPVR +PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSADLLKFTEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCCGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGCACTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATTCAGGTGCCGGAGTCGGCCATAGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGCCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTACCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCATACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGTTGGGAGAGCTACGCCTATCCGTTGACCGAGCAGGCGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|718|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "764", "ARO_accession": "3002156", "ARO_name": "FOX-2", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.45007e-77, "max_identities": 116, "bit_score": 238.039, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  + + P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+E+L++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFVEANM", "sequence_from_broadstreet": "MQQRRALALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGCTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACGCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCACCACGCCCCTTGGCTCAAAGGTTCCGCTTTCGATGGTGTGACTATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCTGATGAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGAAACTGATGAGCCAGACCCTGCTGCCCAAGCTTGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTACTGGCGGCCGAGGCTTACGGGATCAAAACCGGCTCGGCGGATCTGCTGAAGTTTGTCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGCTACGCCTATCCGGTGACCGAGCAGGCGTTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACCGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|934|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "990", "ARO_accession": "3002163", "ARO_name": "FOX-9", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.76099e-77, "max_identities": 116, "bit_score": 238.039, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ P+ V S   +  +Y+ W P    G  R YAN+SIGLFG L AN+ G  +EQL++  +L  LGL HT+I VPESA + YAYGY K +KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTVTVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSNDKMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTVTVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSNDKMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYDYPVTEQVLLADNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACCTATGCCAGCGGGGAGGCCCCGCTGACCGTCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAAACCCTGACCGCGACCCTTGGCGCTTATGCAGCGGTCAAGGGAGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTGAAAGGTTCCGCCTTTGATGGGGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGAAGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGTTGGTCACCGGTTTATCCGGCGGGGACCCACCGTCAGTACGCCAATACCAGTATCGGTCTGTTCGGCTATCTGGCTGCCAACTCCCTGGGCCAGTCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGAGAAGCCCATCCGGGTCACTCCGGGCATGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGTTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGACAACTCACCAGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGTTTTGCTGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACCGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATAGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|1626|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1726", "ARO_accession": "3002158", "ARO_name": "FOX-4", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.46882e-76, "max_identities": 116, "bit_score": 236.884, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+R +PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANM", "sequence_from_broadstreet": "MQQRRALALLMLGSLLLAPCTYASGEAPLTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGCTCGCGCTACTGATGCTGGGTAGCCTGCTGTTAGCCCCTTGCACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCTGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGCGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTTGGCGCCTATGCCGCAGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTAGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAACTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCTATCCGGGCCACTCCGGGCGTGCTGGCTGCCGAGGCTTACGGGATCAAGACCGGTTCGGCGGATCTGCTGAAGTTTGTCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCACACCGGCTTCCATTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCACCAGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGTGGCTTTGGCGCCTATGTGGCGTTCGTGCCTGCCAGAGGGATAGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|1713|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1813", "ARO_accession": "3002184", "ARO_name": "MOX-4", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.08778e-76, "max_identities": 124, "bit_score": 235.728, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA  A   SA D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAH-AGDTSAVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDTSAVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAEVILEANPTAAPRESGNLMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTTTGGCCACCCTGATGTGGGCCGGTCTGGCTCATGCCGGTGACACTTCAGCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCGAGGTGATTCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAACCTGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.21}, "gnl|BL_ORD_ID|392|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "422", "ARO_accession": "3002162", "ARO_name": "FOX-10", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.22205e-76, "max_identities": 118, "bit_score": 235.728, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SI LFG L AN+ G P+EQL++  +L  LGL HT+I VPESA   YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSISLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSISLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGGCGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGTTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAAGCCCACTATTTCAACTATGGGGTTGCCAACCGGGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACTGCGACCCTCGGTGCCTATGCCGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATCAGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTACCGGAGTCGGCTATGGTGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCAGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGTTACGCCTATCCGGTGACCGAGCAGACATTGCTGGCGGGTAACGCACCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAGGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.86}, "gnl|BL_ORD_ID|2163|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2329", "ARO_accession": "3002191", "ARO_name": "MOX-9", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.56454e-76, "max_identities": 121, "bit_score": 235.343, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M   +++TL+ A LA  A   + AD +  +VD++I+P++ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V S   +  +Y+QW P+ + G  R Y+N SIGLFG L A + G P+EQL++  +L  LGL HT++ VP  A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L++   NM", "sequence_from_db": "MTLLMASTLLWAGLA-QATADTQADPLRPLVDASIRPVLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGARVSEQTLFEIGSVSKTLTATLGAYAVVKGALKLDDKVSQHGPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSIDKMRAYYRQWTPAYRAGSHRQYSNPSIGLFGHLAAQSLGQPFEQLMSQTLLPGLGLEHTYLKVPAEAMANYAYGYSKEDKPIRVNPGVLADEAYGIKTSSADLLKFVGANM", "sequence_from_broadstreet": "MQQQVRMTLLMASTLLWAGLAQATADTQADPLRPLVDASIRPVLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGARVSEQTLFEIGSVSKTLTATLGAYAVVKGALKLDDKVSQHGPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSIDKMRAYYRQWTPAYRAGSHRQYSNPSIGLFGHLAAQSLGQPFEQLMSQTLLPGLGLEHTYLKVPAEAMANYAYGYSKEDKPIRVNPGVLADEAYGIKTSSADLLKFVGANMTGTGDEAMQQAIALTHKGVYSVGAMTQGLGWESYAYPVTEETLLAGNSGKVILEANPTAPASNETGSQVLFNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPIQARVETAHAILSKLAE", "dna_sequence_from_broadstreet": "ATGCAACAACAGGTGCGGATGACATTGCTGATGGCGAGCACGCTGCTCTGGGCCGGTCTGGCCCAGGCCACGGCGGACACCCAGGCCGATCCCCTGCGCCCCCTGGTGGATGCCAGTATCCGGCCCGTGCTCAAGGAGCACCGGATCCCCGGCATGGCGGTGGCGGTGCTGAAAGATGGCAAGGCCCACTACTTCAACTACGGGGTGGCCAACCGGGAGAGCGGGGCCCGTGTCAGCGAGCAGACCCTGTTCGAGATTGGATCGGTCAGCAAGACTCTTACGGCAACGCTTGGGGCTTATGCCGTGGTGAAGGGGGCGCTCAAGCTCGATGACAAGGTGAGTCAGCATGGGCCCTGGCTGAAAGGATCGGCTTTTGACGGTATCACCATGGCCGAGCTCGCCACCTACAGCGCCGGGGGCTTGCCGCTGCAATTCCCCGACGAGGTGGATTCCATCGACAAGATGCGTGCCTACTATCGCCAGTGGACGCCTGCCTATCGGGCGGGCAGCCATCGCCAGTACTCCAACCCCAGCATCGGCCTGTTCGGCCATCTCGCGGCCCAGAGCCTGGGCCAACCCTTTGAACAGTTGATGAGCCAGACCCTGCTGCCCGGGCTTGGTCTCGAGCACACCTATCTCAAGGTCCCTGCCGAGGCCATGGCGAACTACGCCTATGGCTACTCGAAAGAGGACAAGCCTATCAGGGTCAACCCGGGGGTCCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGAAGTTTGTCGGCGCCAACATGACAGGCACCGGGGACGAGGCGATGCAGCAGGCGATTGCCCTGACCCACAAGGGGGTTTACTCGGTGGGTGCCATGACTCAGGGGCTCGGCTGGGAGAGTTATGCCTATCCCGTGACCGAAGAGACCTTGCTTGCAGGCAACTCGGGCAAGGTGATCCTCGAGGCCAACCCGACGGCGCCCGCCTCCAACGAGACGGGTAGCCAGGTGCTCTTCAACAAGACCGGCTCCACCGGCGGCTTTGGTGCCTATGTGGCCTTTGTGCCAGCCAAGGGGATTGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCAGGCCAGGGTAGAGACGGCCCACGCCATCCTGAGCAAGCTGGCCGAGTGA", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.9}, "gnl|BL_ORD_ID|2212|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3347", "ARO_accession": "3004648", "ARO_name": "AQU-3", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.99135e-75, "max_identities": 114, "bit_score": 234.187, "cvterm_id": "39651", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV   G+ +YFNYG A++   + V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDDVIRPLVKEHRIPGMAVAVLKGGQAHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MKQTSPLSLLALSALLLSPLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVLKGGQAHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANINGVDDKGLQQAIALTHQGHYSVGGMTQGLGWESYPYPVSEQTLQVGNSREVSFKGNPVKGFKAPVTFGEARLYNKTGSTNGFGAYVAFVXAKGVGIVMLANRNYPIQERVKAAHAILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTTGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGACGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGGGGGGCAGGCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCAACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATTACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGCCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCAGGGCTCGGCCTGCATCACACCTATATCAATGTGCCTAAGCAGGCGATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCACGCCAGGGGTGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCAACGGGGTGGATGACAAGGGGTTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCACTACTCGGTAGGCGGGATGACTCAGGGGCTGGGCTGGGAGAGCTACCCCTATCCAGTCAGTGAGCAGACGCTGCAGGTTGGGAACTCCCGCGAGGTGAGTTTCAAGGGCAATCCTGTCAAAGGATTCAAGGCGCCGGTTACATTTGGTGAGGCGCGGCTCTACAACAAGACCGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCMGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACGCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.51}, "gnl|BL_ORD_ID|1396|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1485", "ARO_accession": "3002190", "ARO_name": "MOX-8", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.09297e-75, "max_identities": 122, "bit_score": 234.187, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTTTGGCCACCCTGATGTGGGCCGGTCTGGCTCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCAACCCGGCGGCGCCCGCGCCCGCTGCGGCAGGGCACCCTGTGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|646|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "688", "ARO_accession": "3002183", "ARO_name": "MOX-2", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.63961e-75, "max_identities": 122, "bit_score": 233.417, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGE-TSPVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGETSPVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVHDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGACTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTCATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|1403|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1492", "ARO_accession": "3002186", "ARO_name": "MOX-3", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.0742e-75, "max_identities": 122, "bit_score": 232.646, "cvterm_id": "36942", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGE-TSPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGETSPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWERYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGACTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAAACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|1542|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1637", "ARO_accession": "3002189", "ARO_name": "MOX-7", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.14956e-75, "max_identities": 121, "bit_score": 232.261, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A L  +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R YAN SIGLFG L A++   P+++L+   +L  LGL HT++TVPE A   YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLVHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLVHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANIGGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSPAMIYNAIPAVPAPAAAGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEARIKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCTTGATGTGGGCCGGCTTGGTTCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGTTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGAGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGTCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCAGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACTCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTCTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCCTGATGGAGCAGACGATGCTGCCGGGGCTAGGCCTGTACCATACTTACCTCACTGTGCCCGAGCAGGCCATGGGGCACTACGCCTACGGCTACTCGAAGGAGGACAAGCCGATCCGCGTCACTCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGTTCGGCGGATCTGCTGCGCTTTGTGAAGGCGAACATCGGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGACCTGACTCACCAGGGCCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCATCCCGGCTGTGCCCGCGCCCGCTGCGGCAGGCCACCCTGTGCTTTTCAACAAGACCGGCTCGACCAATGGCTTCGGGGCTTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAACTCTCCCATCGAGGCGCGCATCAAGGCGGCTCACGCAATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.02}, "gnl|BL_ORD_ID|1290|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1376", "ARO_accession": "3002185", "ARO_name": "MOX-6", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.14705e-74, "max_identities": 122, "bit_score": 232.261, "cvterm_id": "36936", "query": "TLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "TL+ A LA  A   +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R YAN SIGLFG L A++   P+++L+   IL  LGL HT++ VPE A   YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "TLMWAGLA-HAGDRAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGVLPTLMWAGLAHAGDRAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSAAMIYNANPAAPAPAARGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEGTLKAGHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGTTCTGCCCACCCTGATGTGGGCCGGCCTGGCCCATGCAGGTGACAGGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGTTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGAGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGTCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTCTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCCTGATGGAGCAGACGATCCTGCCGGGGCTTGGCCTGTACCATACCTACCTCAATGTGCCCGAGCAGGCCATGGGGCACTACGCCTACGGCTACTCGAAGGAGGACAAGCCCATCCGCGTCACTCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGACCTGACTCACCAGGGGCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCGCGGCGATGATTTACAATGCGAACCCGGCTGCGCCCGCGCCCGCTGCAAGGGGGCACCCTGTGCTCTTCAACAAGACCGGCTCGACCAACGGCTTCGGGGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAACTCTCCCATCGAGGGCACGCTCAAGGCGGGCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1867, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.61}, "gnl|BL_ORD_ID|249|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "269", "ARO_accession": "3002019", "ARO_name": "CMY-8", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.28369e-73, "max_identities": 119, "bit_score": 229.565, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|986|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1049", "ARO_accession": "3002182", "ARO_name": "MOX-1", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.29758e-73, "max_identities": 119, "bit_score": 229.565, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGAGCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|1289|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1375", "ARO_accession": "3002022", "ARO_name": "CMY-11", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44499e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "35914", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGAGCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|15|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "20", "ARO_accession": "3002012", "ARO_name": "CMY-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52486e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCAACGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|766|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "812", "ARO_accession": "3002021", "ARO_name": "CMY-10", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.59192e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "36770", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|121|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "136", "ARO_accession": "3002020", "ARO_name": "CMY-9", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.08793e-73, "max_identities": 118, "bit_score": 228.024, "cvterm_id": "35914", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLF++GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGATATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|1059|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1129", "ARO_accession": "3002030", "ARO_name": "CMY-19", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.42714e-73, "max_identities": 118, "bit_score": 227.639, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLF++GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGATATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGAGCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|2570|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "TRU-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2889", "ARO_accession": "3004450", "ARO_name": "TRU-1", "ARO_category": {"41644": {"category_aro_accession": "3004449", "category_aro_cvterm_id": "41644", "category_aro_name": "TRU beta-lactamase", "category_aro_description": "A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi)", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.79088e-72, "max_identities": 112, "bit_score": 226.483, "cvterm_id": "41646", "query": "FSAADN-VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++AAD  +A +V+  ++PL+ +  IPGMAVAV  +GKP+YFNYG A+ ++ + ++E TLFE+GSVSKTFT  LG  +V K    L+D  +++ P L    +  +T+  LATY+AGGLPLQ PDAV S   +  +Y+QW P    G  R Y+N SIGLFG L A+  G P+ QL++  +L  L L HT++ VP++A   YAYGY K  KPVRV+PG L  E+YG+K+++ D++++   NM  S", "sequence_from_db": "YAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTFTATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFGHLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGS", "sequence_from_broadstreet": "MKQRIALSLLALGPLLLVPRVYAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTFTATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFGHLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGSGDKAVQQALAMTRTGFYSVGEMTQGLGWESYAYPVTEQALLAGNSPAVSFKANPVKPFVAPRVMGNERLYNKTGSTNGFGAYVVFVPARGVGIVMLANRNYPIEARVKAAYAIMRHLAP", "dna_sequence_from_broadstreet": "ATGAAACAACGAATCGCGCTATCACTGCTGGCATTGGGGCCCCTGTTGCTCGTCCCACGCGTTTATGCCGCGGCAGATGAGCCCATGGCGAACATAGTGGAAAAGGCTGTCCAGCCGCTGCTGGAGGAGTACCGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGAGGGCAAGCCTCACTACTTCAATTATGGCGTCGCCAATCGGGAGAGCGGCCGGCGCATCAGCGAGCGGACCCTGTTCGAGATTGGTTCGGTCAGCAAGACCTTTACTGCGACCTTGGGCACCTACGCGGTCGTCAAAGGGGGCTTTCGGCTGGATGACAAGGTGAGCCAGCACGCGCCTTGGTTGCAGAATTCGGCGTTTGATCGCGTCACCATGGCCCAGCTGGCGACCTACAGCGCAGGGGGCTTGCCGTTGCAGTTTCCCGATGCGGTCGACTCAAACGAGAGAATGCGCCAGTACTACCGGCAGTGGTCACCGCTTTATGCGGCAGGCACTCATCGCGAGTACTCCAACCCCAGCATAGGTCTGTTCGGCCATCTGGCGGCGAGCACCCTGGGCCAACCATTCAGACAACTGATGAGCCAGACTCTGCTGCCCAAGCTCGATTTGCAGCACACCTATCTCGAGGTGCCAGACGCAGCCATGGTTGACTACGCCTATGGCTATTCGAAGGAAGACAAACCCGTCAGGGTCAATCCCGGAGTGCTGGCGGACGAAGCCTATGGCATCAAGACCAGCGCGGCGGATCTCATCAAGTTTGTGGGCGCCAACATGACAGGCAGTGGCGACAAGGCGGTGCAGCAAGCGCTGGCCATGACCCGTACCGGTTTCTACTCGGTGGGAGAGATGACCCAGGGGCTGGGGTGGGAGAGCTACGCCTATCCCGTGACCGAACAGGCGCTGCTGGCGGGCAATTCACCGGCGGTGAGCTTCAAGGCCAATCCGGTCAAACCCTTTGTGGCTCCCAGAGTGATGGGGAACGAGCGACTCTACAACAAGACAGGCTCGACCAACGGCTTTGGTGCCTATGTGGTGTTTGTCCCGGCCAGAGGCGTGGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCCAGGGTCAAGGCTGCCTATGCCATCATGCGCCATCTGGCACCCTGA", "partial": "0", "query_start": 1906, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.28}, "gnl|BL_ORD_ID|278|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CepS beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "299", "ARO_accession": "3003553", "ARO_name": "CepS", "ARO_category": {"41363": {"category_aro_accession": "3004199", "category_aro_cvterm_id": "41363", "category_aro_name": "CepS beta-lactamase", "category_aro_description": "CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.97165e-72, "max_identities": 111, "bit_score": 224.942, "cvterm_id": "36957", "query": "DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "D + AVVD  I+P++ Q  IPGMAVAV   G+ +YFNYG AD+     V E TLFE+GSVSKT+T  LGA +V K    L+D  + + P L    + GIT+ +LATY+AGGLPLQ PD V S   +  +Y+ W P  + G  R Y+N SIGLFG L A++   P+  L+   +L  LGL HT++ VPE+A ++YA+GY K  KP+RV+PG L  E+YG+K+ S D+L + + N+", "sequence_from_db": "DPLKAVVDDAIRPVLKQHRIPGMAVAVLKGGQAHYFNYGLADVATGAKVNEQTLFEIGSVSKTYTATLGAYAVVKGGFKLDDQVSGHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSSDTMRAYYRHWTPPYQAGTQRQYSNPSIGLFGHLAASSLQQPFSTLMEQTLLPALGLEHTYLQVPEAAMARYAFGYSKEDKPIRVNPGMLADEAYGIKTGSADLLAFVKANI", "sequence_from_broadstreet": "MKQTRALPLLALGTLLLAPLSLAAPVDPLKAVVDDAIRPVLKQHRIPGMAVAVLKGGQAHYFNYGLADVATGAKVNEQTLFEIGSVSKTYTATLGAYAVVKGGFKLDDQVSGHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSSDTMRAYYRHWTPPYQAGTQRQYSNPSIGLFGHLAASSLQQPFSTLMEQTLLPALGLEHTYLQVPEAAMARYAFGYSKEDKPIRVNPGMLADEAYGIKTGSADLLAFVKANISGVDDKALQQAIALTHTGFYRIGEMSQGLGWESYAYPVSEQTLLAGNSPAVSLKANPVTKFETPAAPGAMRLYNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPIEARVSAAHAILSQLAP", "dna_sequence_from_broadstreet": "ATGAAACAGACCAGAGCCCTGCCACTGCTGGCCCTCGGCACCCTGCTGCTTGCCCCGCTCTCCCTGGCGGCCCCCGTCGATCCGCTGAAGGCGGTGGTGGATGACGCCATCCGCCCCGTGCTCAAGCAGCACAGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGGGGGGCAGGCCCACTACTTCAACTACGGGCTGGCCGATGTGGCGACCGGGGCCAAGGTCAATGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCTATACCGCCACCCTTGGCGCCTACGCCGTGGTCAAGGGGGGCTTCAAGCTCGATGACCAGGTGAGCGGGCACGCACCCTGGCTCAAGGGCTCCGCCTTCGATGGCATCACCATGGCGGAACTTGCCACCTACAGTGCCGGGGGGCTGCCGCTGCAATTCCCCGACGAGGTTGATTCGAGCGATACCATGCGGGCCTATTACCGGCACTGGACGCCGCCATATCAGGCGGGAACCCAGCGCCAATACTCCAATCCCAGCATCGGCCTGTTCGGCCATCTGGCGGCGAGCAGCCTGCAGCAGCCGTTTTCCACGTTGATGGAGCAGACCCTGCTGCCAGCACTCGGGTTGGAGCACACCTATCTGCAGGTGCCCGAGGCCGCCATGGCTCGCTACGCCTTCGGCTACTCGAAGGAGGACAAACCCATCAGGGTCAACCCTGGCATGCTGGCCGACGAGGCCTACGGCATCAAGACCGGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAATATCAGCGGGGTTGATGACAAGGCGTTGCAACAGGCGATCGCCCTGACCCACACCGGTTTTTATCGGATAGGGGAGATGAGCCAGGGGCTGGGCTGGGAGAGCTACGCCTACCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCCTCAAGGCCAATCCGGTCACTAAGTTCGAGACGCCAGCCGCGCCCGGGGCTATGCGCCTCTACAACAAGACCGGGTCGACCGGTGGCTTCGGCGCCTACGTGGCCTTCGTGCCCGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAATTATCCCATCGAGGCCAGAGTCAGCGCGGCCCATGCCATTTTGAGCCAGCTGGCACCCTGA", "partial": "0", "query_start": 1918, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.44}, "gnl|BL_ORD_ID|43|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "53", "ARO_accession": "3002188", "ARO_name": "MOX-5", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.84564e-70, "max_identities": 118, "bit_score": 220.705, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+   G  R YAN SIGLFG L A++   P+++L+   +L  LGL HT++ VPE     YAYGY K  KP RV+P  L  E YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYPYPVSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFKKTGSTNGFGAYVAFVPAKGIGVVMLANRNYPNEGTLKAGHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCCTGATGTGGGCCGGTTTGGCCCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGGGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGCCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCGGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTTTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCTTGATGGAGCAGACGATGCTGCCGGGGCTTGGCCTGTACCATACCTACCTCAATGTGCCCGAGCAGCCCATGGGGCACTACGCCTACGGTTACTGGAAGGAGGACAAGCCATTCCGCGTCACTCCCGCCATGCTGGCGGAGGAGCCTTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTCGTGAAGGCGAACATCAGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGATCTGACTCACCAGGGCCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACCCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCAACCCGGCGGCGCCCGCGCCCGCTGCGGCAGGGCACCCTGTGCTCTTCAAAAAGACCGGCTCGACCAATGGCTTCGGGGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCGTCGTCATGCTGGCCAATCGCAACTACCCCAACGAGGGCACGCTCAAGGCGGGCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|2201|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2341", "ARO_accession": "3003854", "ARO_name": "ADC-8", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35412e-69, "max_identities": 107, "bit_score": 219.55, "cvterm_id": "41144", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "VD   KPLMAQ  I GMA+AVS+ G+ YY NYG A  Q +Q V+E+TLFELGSVSK F   L   + A+ ++ L+D  A+Y PEL        TLL+L TYTAGG PLQ P+ +K+  D+  ++Q WQP   P  +R Y+N SIGL G +TA A    Y  L+   +   LG+ H++I VP +  S YA+GY+  + +RVSPG  DAE+YG+KS + DML++ +  + P", "sequence_from_db": "VDRHFKPLMAQYQISGMAIAVSINGQHYYQNYGVASKQTEQNVSEHTLFELGSVSKLFNATLTGYAQAQGQLKLSDHPAQYFPELKNTAVNQATLLNLGTYTAGGFPLQFPEQIKTTQDMTQYFQHWQPKAAPRRIREYSNPSIGLMGYVTALAMKNSYSNLIENTLFPALGMHHSYINVPAAQMSNYAWGYQADQAIRVSPGMFDAEAYGIKSNTADMLKFLDAQINP", "sequence_from_broadstreet": "MMKDILGNLDNVPFKIMTGCIAGLLSCGTVAQSTVQQSIQQSVDRHFKPLMAQYQISGMAIAVSINGQHYYQNYGVASKQTEQNVSEHTLFELGSVSKLFNATLTGYAQAQGQLKLSDHPAQYFPELKNTAVNQATLLNLGTYTAGGFPLQFPEQIKTTQDMTQYFQHWQPKAAPRRIREYSNPSIGLMGYVTALAMKNSYSNLIENTLFPALGMHHSYINVPAAQMSNYAWGYQADQAIRVSPGMFDAEAYGIKSNTADMLKFLDAQINPQNLKPTLRKAIQTTQMGYFRVGQMRQGLGWEQYTYPVSLTTLLAGNSAKMALQPQPVTGISKPITAPQQALLNKTGATNGFSAYVVVIPSQKIGLVMLANRNFPNDARVKAAYATLQQILNADIQK", "dna_sequence_from_broadstreet": "ATGATGAAAGACATATTAGGTAACTTAGATAACGTGCCATTTAAGATCATGACAGGCTGTATTGCAGGACTATTGTCCTGTGGTACGGTCGCTCAATCGACAGTCCAACAATCAATTCAACAAAGTGTAGATCGACATTTTAAGCCCCTTATGGCTCAGTATCAAATTTCAGGAATGGCGATTGCGGTCAGCATAAATGGGCAACATTACTATCAGAATTATGGCGTAGCATCTAAACAGACCGAGCAAAATGTCTCTGAACATACTCTATTTGAGTTGGGTTCGGTGAGTAAGCTCTTTAATGCAACGCTGACGGGATATGCTCAAGCACAAGGTCAACTTAAGTTGAGTGATCATCCTGCCCAATATTTTCCAGAATTAAAAAATACAGCAGTGAATCAGGCGACTCTCCTGAATCTGGGGACCTATACCGCAGGTGGTTTTCCGCTACAGTTTCCTGAGCAGATCAAGACAACACAAGACATGACTCAGTATTTTCAGCACTGGCAGCCTAAAGCGGCTCCAAGACGTATTCGAGAATATTCAAATCCAAGCATTGGCTTGATGGGCTATGTCACCGCACTTGCGATGAAAAATAGCTATTCAAATCTAATTGAAAATACGTTATTCCCTGCGTTGGGGATGCATCATAGCTATATCAACGTTCCAGCAGCGCAGATGTCAAATTATGCATGGGGATATCAGGCAGATCAGGCGATACGTGTCTCACCAGGTATGTTTGATGCAGAGGCGTATGGCATCAAAAGTAACACTGCCGATATGCTTAAATTTCTAGATGCTCAAATAAATCCCCAAAATCTAAAACCCACGCTCCGAAAGGCCATACAAACCACTCAGATGGGTTATTTTCGGGTGGGACAGATGCGACAGGGCTTGGGTTGGGAGCAATATACTTATCCAGTATCCTTAACAACCTTGCTGGCGGGAAATTCCGCTAAAATGGCTCTACAGCCTCAACCTGTTACAGGCATTTCAAAACCTATCACTGCTCCGCAGCAGGCCCTTTTGAATAAAACTGGTGCAACCAATGGTTTTTCGGCTTATGTGGTGGTTATTCCGAGCCAAAAGATTGGACTGGTGATGCTTGCCAATCGTAATTTTCCCAATGATGCACGGGTGAAAGCAGCTTATGCCACACTACAGCAAATCCTCAATGCAGATATTCAGAAATGA", "partial": "0", "query_start": 1936, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.72}, "gnl|BL_ORD_ID|1961|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2119", "ARO_accession": "3002489", "ARO_name": "LRA-10", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.25991e-69, "max_identities": 113, "bit_score": 217.238, "cvterm_id": "39682", "query": "AADN---VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN-KKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPV", "match": "AAD+   + A+VD  I+P+MA+ D+PGMAVAV+V G+P+ FNYG A  ++  PV++ TLFELGS+SKTF   L + +    +++L+D   KY P+L        TLL+L TYTAGGLPLQ PD V S   + +++Q W+P   PG  R Y+N S+GLFG LT+ A    +   L   +L  +G+  T++ VP+SA + YA+GY    KP R++PG L    YG++S + DM+R+ + N+ P      G L TPL  +  G  V", "sequence_from_db": "AADDSARIRAIVDQAIRPVMAEHDVPGMAVAVTVDGQPFVFNYGVASRESNTPVSDATLFELGSISKTFAATLASYAQVTGKLSLDDHPGKYMPQLKGSAIDKATLLNLGTYTAGGLPLQFPDDV-SDQQMASYFQHWKPKAAPGVQRTYSNPSLGLFGHLTSLALKSRFTDALETNVLTQMGMKSTYVHVPQSAMANYAWGYDQANKPGRMNPGVLADGIYGIRSTAADMIRYVQANIAP------GKLETPLRRAVEGTHV", "sequence_from_broadstreet": "MAIAILSSCFAPLASRAADDSARIRAIVDQAIRPVMAEHDVPGMAVAVTVDGQPFVFNYGVASRESNTPVSDATLFELGSISKTFAATLASYAQVTGKLSLDDHPGKYMPQLKGSAIDKATLLNLGTYTAGGLPLQFPDDVSDQQMASYFQHWKPKAAPGVQRTYSNPSLGLFGHLTSLALKSRFTDALETNVLTQMGMKSTYVHVPQSAMANYAWGYDQANKPGRMNPGVLADGIYGIRSTAADMIRYVQANIAPGKLETPLRRAVEGTHVGYFKVGGMVQGLGWEQYPYPVSLQQLQAGNSTTMAWEANPAQKLTPPSVPSGATLFNKTGSTSRFGAYVAFVPEKKIGIVILANKNIPGPDRIKAAHAILEQL", "dna_sequence_from_broadstreet": "ATGGCAATCGCCATCCTGTCTTCCTGTTTCGCGCCGCTCGCCAGCCGGGCCGCCGACGACAGCGCCAGGATCCGCGCCATCGTCGACCAGGCGATACGCCCCGTCATGGCCGAACACGACGTGCCGGGCATGGCGGTCGCCGTGACGGTCGACGGCCAACCGTTCGTCTTCAACTATGGCGTCGCCTCGCGCGAGAGCAACACGCCCGTCAGCGACGCGACGCTGTTCGAGCTCGGCTCCATCAGCAAGACTTTTGCCGCCACGCTGGCCTCGTATGCGCAGGTGACCGGCAAGCTGTCGCTGGACGACCATCCCGGCAAGTACATGCCGCAGCTGAAGGGCAGCGCGATCGACAAGGCCACCCTGCTCAATCTGGGCACCTACACGGCGGGCGGACTGCCGCTGCAATTCCCGGACGACGTCTCGGACCAGCAGATGGCCAGCTACTTCCAGCACTGGAAACCGAAGGCCGCGCCCGGCGTACAACGGACCTATTCCAATCCCAGCCTCGGGCTGTTCGGACACCTGACCAGCCTTGCGCTGAAGAGCCGTTTTACCGACGCGCTGGAAACGAATGTCCTCACGCAGATGGGCATGAAGAGCACCTATGTCCACGTGCCACAAAGCGCCATGGCCAATTACGCCTGGGGATACGATCAAGCAAACAAGCCTGGCCGCATGAACCCCGGCGTCCTCGCCGACGGAATCTATGGCATCCGGTCGACAGCCGCCGACATGATCCGCTATGTGCAAGCCAACATCGCCCCGGGCAAGCTGGAAACGCCGTTGCGGCGCGCGGTGGAAGGCACCCATGTCGGCTACTTCAAGGTGGGCGGCATGGTGCAGGGACTCGGCTGGGAGCAATACCCTTACCCGGTCTCCCTGCAGCAGCTACAGGCCGGCAACTCCACCACCATGGCATGGGAAGCCAACCCCGCGCAGAAACTCACGCCGCCGAGCGTACCGTCCGGCGCGACCCTGTTCAACAAGACCGGCTCCACCAGCCGCTTCGGCGCCTACGTGGCGTTCGTGCCGGAGAAGAAAATCGGCATCGTCATCCTCGCGAACAAGAACATCCCGGGTCCGGACCGTATCAAGGCGGCCCATGCGATCCTGGAACAACTGTAA", "partial": "0", "query_start": 1912, "query_end": 2688, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.97}, "gnl|BL_ORD_ID|1775|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "SRT-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "1878", "ARO_accession": "3002494", "ARO_name": "SRT-2", "ARO_category": {"36234": {"category_aro_accession": "3000095", "category_aro_cvterm_id": "36234", "category_aro_name": "SRT beta-lactamase", "category_aro_description": "SRT beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.77291e-69, "max_identities": 111, "bit_score": 216.853, "cvterm_id": "36783", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGF", "match": "+D+ I+PLM +  +PGMA+AVSV GK   + YG A  Q  +P+TE TLFE+GS+SKTFT  L   +  + +++ NDPA++Y PEL    + G++LL+LAT+T+ GLPL VPD V + A L+ +Y+ WQP    G  R+Y+N  IG+ G + A +   P+ Q +   +L  LG+SHT++ VP +  + YA GY K+ KPVRV+PG LDAESYG+KS ++D++R+ + N++  +                  P R   +AT VG+", "sequence_from_db": "IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTS-GLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQ---------------PWRDALAATHVGY", "sequence_from_broadstreet": "MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQPWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR", "dna_sequence_from_broadstreet": "ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGGAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACTAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGTGTCTATTCCAACCTCGGCATCGGCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAACCCCGGCCCGCTGGATGCCGAGTCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCAGCCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCGCCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA", "partial": "0", "query_start": 1936, "query_end": 2721, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.21}, "gnl|BL_ORD_ID|184|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "SRT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "199", "ARO_accession": "3002493", "ARO_name": "SRT-1", "ARO_category": {"36234": {"category_aro_accession": "3000095", "category_aro_cvterm_id": "36234", "category_aro_name": "SRT beta-lactamase", "category_aro_description": "SRT beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4167e-67, "max_identities": 104, "bit_score": 213.001, "cvterm_id": "36783", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "+D+ I+PLM +  +PGMA+AVSV GK   + YG A  Q  +P+TE TLFE+GS+SKTFT  L   +  + +++ NDPA++Y PEL    + G++LL+LAT+T+ GLPL VPD V + A L+ +Y+ WQP    G  R+Y+N  I + G + A +   P+ Q +   +L  LG+SHT++ VP +  + YA GY K+ KPVRV+PG LDA+SYG+KS ++D++R+ + N++  +  +A", "sequence_from_db": "IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTS-GLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIVMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAKSYGIKSNARDLIRYLDANLQQVKVAHA", "sequence_from_broadstreet": "MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIVMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAKSYGIKSNARDLIRYLDANLQQVKVAHAWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR", "dna_sequence_from_broadstreet": "ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGCAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACCAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGCGTCTATTCCAACCTCGGCATCGTCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAATCCCGGCCCGCTGGACGCCAAATCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCACGCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCACCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA", "partial": "0", "query_start": 1936, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 44.07}, "gnl|BL_ORD_ID|2513|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2346", "ARO_accession": "3003860", "ARO_name": "ADC-16", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08384e-66, "max_identities": 107, "bit_score": 210.305, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS+  ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K  ++ ND   KY  EL       + LL LATYT+G L LQ PD VK+   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSSSIYAGNTPKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKTKGTISFNDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSSSIYAGNTPKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKTKGTISFNDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPANIQRAINETHQGFYQVGTMYQALGWEEFSYPALLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTAGCTCAATTTATGCGGGTAATACACCAAAAGAGCAAGAGATCAAAAAACTGGTTGATCAAAATTTTAAGCCTTTATTAGAAAAATATGATGTGCCCGGTATGGCTGTGGGCGTTATTCAAAATAACAAAAAGTATGAAATGTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTTAATAGCAATACCATTTTTGAGCTAGGCTCGGTCAGTAAATTATTTACCGCTACAGCAGGCGGATATGCCAAAACAAAAGGAACAATCTCTTTTAATGACACGCCTGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGATCAAGTGAATTTACTTCAACTTGCGACATATACCAGTGGCAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACGTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTGGAAAAAACCATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTGCCTAAAACTCAAATGCAAAACTATGCATTTGGCTATAACCAAGAAAATCAGCCGATTCGCGTCAATCCTGGTCCACTCGATGCACCAGCATACGGCGTTAAATCTACCCTACCGGATATGCTGAGTTTTATTAATGCAAACCTAAATCCACAAAAATATCCAGCAAATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACCATGTATCAAGCACTAGGTTGGGAAGAGTTCTCTTATCCAGCACTTTTACAAACTTTATTAGACAGTAATTCAGAACAAATCGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCCGTTAAGATGTTCCACAAAACTGGATCGACTAACGGTTTTGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACTAATAAACGTATTCCCAATGAAGAACGCATTAAAGCAGCTTATGCTGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.53}, "gnl|BL_ORD_ID|2200|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2340", "ARO_accession": "3003853", "ARO_name": "ADC-7", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1125e-66, "max_identities": 109, "bit_score": 209.534, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAATACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAGCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.98}, "gnl|BL_ORD_ID|2199|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2340", "ARO_accession": "3003853", "ARO_name": "ADC-7", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1125e-66, "max_identities": 109, "bit_score": 209.534, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAATACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAGCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.98}, "gnl|BL_ORD_ID|2432|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2350", "ARO_accession": "3003864", "ARO_name": "ADC-20", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35251e-65, "max_identities": 108, "bit_score": 208.764, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D + KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKTVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKTVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGTGTTATTCAGAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAACCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGTCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAATTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCCTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAAGCAGCGTATGCCGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.6}, "gnl|BL_ORD_ID|2130|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3315", "ARO_accession": "3004617", "ARO_name": "ADC-30", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28586e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2521|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2364", "ARO_accession": "3003881", "ARO_name": "ADC-75", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.36049e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2175|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-67", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3332", "ARO_accession": "3004633", "ARO_name": "ADC-67", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.3859e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2524|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2367", "ARO_accession": "3003884", "ARO_name": "ADC-78", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.57163e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2527|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2371", "ARO_accession": "3003888", "ARO_name": "ADC-82", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.59931e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "42628", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDALAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDALAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCTAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2459|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2354", "ARO_accession": "3003868", "ARO_name": "ADC-25", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.74228e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2141|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Acinetobacter baumannii AmpC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2300", "ARO_accession": "3003796", "ARO_name": "Acinetobacter baumannii ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.98756e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35531", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2133|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3310", "ARO_accession": "3004615", "ARO_name": "ADC-11", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05223e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35535", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2338|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-39", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2356", "ARO_accession": "3003871", "ARO_name": "ADC-39", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15187e-65, "max_identities": 106, "bit_score": 207.608, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2136|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-59", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3317", "ARO_accession": "3004619", "ARO_name": "ADC-59", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.90457e-65, "max_identities": 106, "bit_score": 207.608, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAATAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2202|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2338", "ARO_accession": "3003851", "ARO_name": "ADC-5", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.32141e-65, "max_identities": 106, "bit_score": 206.838, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLTPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLTPQKYPTDIQRAINETHQGFYQVGTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCATTATTAGAAAAATATGATGTACCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGATCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGCAACCTCGCTTTACAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTTGATGCCCCAGCATACGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTACCCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTCTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2525|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2368", "ARO_accession": "3003885", "ARO_name": "ADC-79", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.66482e-65, "max_identities": 108, "bit_score": 206.838, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MQFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCAATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCATTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTGTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.6}, "gnl|BL_ORD_ID|2431|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2349", "ARO_accession": "3003863", "ARO_name": "ADC-19", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.03437e-64, "max_identities": 104, "bit_score": 206.453, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGF----SAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   +    S    +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  +L       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTSKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKKLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTSKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKKLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPALLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTATCTCCTCTTTTTATTTTTAATACATCAATTTATGCGGGCAATACATCAAAAGAACAAGAAATTAAAAAACTGGTAGATCAGAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTTAGTAAATTATTTACCGCAACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAAAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCACTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCTTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2519|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-61", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2362", "ARO_accession": "3003879", "ARO_name": "ADC-61", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.13897e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P +Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTCTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2131|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-58", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3316", "ARO_accession": "3004618", "ARO_name": "ADC-58", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.15123e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N  P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANFNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANFNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACTTCAACCCACAGAAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCACCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2337|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2355", "ARO_accession": "3003870", "ARO_name": "ADC-31", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.21452e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35649", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P +Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTAGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAGCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2518|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-56", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2361", "ARO_accession": "3003878", "ARO_name": "ADC-56", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30901e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ + Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYQQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYQQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCAACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2203|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2342", "ARO_accession": "3003856", "ARO_name": "ADC-12", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.3231e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDTQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAATCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATACTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2161|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-60", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3318", "ARO_accession": "3004620", "ARO_name": "ADC-60", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.50443e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R +PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGCTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2515|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-42", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2358", "ARO_accession": "3003873", "ARO_name": "ADC-42", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.84369e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D + KY  EL       + LL LATYT+G L LQ PD V++   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQKYPKDTQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAATCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGTCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATACGGTGTTAAATCGACCTTACCTGATATGCTGAGTTTCATTAATGCCAATATAAATCCACAAAAATATCCGAAAGATACTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2167|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2335", "ARO_accession": "3003848", "ARO_name": "ADC-2", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.25941e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "36930", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCTCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTAATGCCAACCTTAACCCACAAAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2520|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2363", "ARO_accession": "3003880", "ARO_name": "ADC-74", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28372e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R +PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGCTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2523|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2366", "ARO_accession": "3003883", "ARO_name": "ADC-77", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.33313e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCTCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTAATGCCAACCTTAACCCACAAAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2176|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "680", "model_id": "3333", "ARO_accession": "3004634", "ARO_name": "ADC-73", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.3836e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +Y VKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYSVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYSVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATAGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2514|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-41", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2357", "ARO_accession": "3003872", "ARO_name": "ADC-41", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08158e-64, "max_identities": 105, "bit_score": 205.297, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKNQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKNQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGIMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGAACCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCATCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2195|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2334", "ARO_accession": "3003847", "ARO_name": "ADC-1", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.38657e-64, "max_identities": 105, "bit_score": 204.912, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG L A +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLGAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLGAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGGTGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACCGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2511|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2345", "ARO_accession": "3003859", "ARO_name": "ADC-15", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.48145e-64, "max_identities": 104, "bit_score": 204.912, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + L  LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++QLL   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTTGKYWKELKNTPIDQVNLFQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQLLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTTGKYWKELKNTPIDQVNLFQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQLLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKIFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAATACCTCAATTTATGCAGGGAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTACGGCCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTCGGTTCAGTTAGTAAATTATTTACCGCTACAGCAGGTGGATATGCCAAAACAAAAGGAACAATTTCTTTTAAAGACACAACCGGAAAATATTGGAAAGAATTAAAAAACACACCAATTGACCAAGTTAACTTATTTCAACTTGCTACTTATACGAGTGGCAACCTTGGCTTACAGTTTCCAGATGAAGTCCAAACAGATCAGCAAGTTTTAACTTTTTTCAAAGACTGGAAGCCTAAAAACTCAATCGGTGAATATCGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCATTGTCTATGAATAAACCTTTCGACCAACTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGTTAGATGCACCTGCGTACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATATTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCGGTGTTAAATGCAATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2207|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-62", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3331", "ARO_accession": "3004632", "ARO_name": "ADC-62", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.43322e-64, "max_identities": 104, "bit_score": 204.527, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R++ G LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRINSGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRINSGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAATTAACTCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2197|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2337", "ARO_accession": "3003850", "ARO_name": "ADC-4", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98239e-64, "max_identities": 105, "bit_score": 204.527, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACTGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCCTTCCGGATATGTTGAGTTTTATTTATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAAAGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACCGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2196|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2336", "ARO_accession": "3003849", "ARO_name": "ADC-3", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.65131e-64, "max_identities": 105, "bit_score": 204.142, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFFFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFFFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLSAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTTTTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACTGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCCTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTTATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAAAGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAGTGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2198|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2339", "ARO_accession": "3003852", "ARO_name": "ADC-6", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.15935e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L  ++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTLFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTLFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPAMLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTGTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCAACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCGGCAGATATTCAACGTGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAATGTTACAAACTTTACTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACGTATGTGGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCGTATGCAGTTTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2510|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2344", "ARO_accession": "3003858", "ARO_name": "ADC-14", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.18257e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERFKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTTGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATTTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAGCTTGCTACCTATACAAGTGGGAACCTTGCTTTGCAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGATTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGACATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACCGCTATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACCAATGGTTTCGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCTTTAAGGCAGCGTATGCAGTGTTAAACGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2509|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2343", "ARO_accession": "3003857", "ARO_name": "ADC-13", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.18257e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTTGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATTTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTTGCTACCTATACAAGTGGGAACCTTGCTTTGCAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGATTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGACATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACCAATGGTTTCGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTGTTAAACGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2692|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-68", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3013", "ARO_accession": "3004493", "ARO_name": "ADC-68", "ARO_category": {"42444": {"category_aro_accession": "3004545", "category_aro_cvterm_id": "42444", "category_aro_name": "ADC beta-lactamase with carbapenemase activity", "category_aro_description": "ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.53146e-63, "max_identities": 104, "bit_score": 202.601, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   GA +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ V ++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGAYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVAKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGAYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVAKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAATACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGCTTATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCTGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAATAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTAGCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCGGCTGATATTCAACGTGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2507|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Laribacter hongkongensis ampC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2845", "ARO_accession": "3004292", "ARO_name": "Laribacter hongkongensis ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.02288e-63, "max_identities": 109, "bit_score": 202.216, "cvterm_id": "41458", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLE", "match": "+D+ ++ +M    IPGMA+A+   GK  Y NYG A  +  QPV E TLFE+GS+SK FT ++   +  +  + L+ PA++Y   L    +  ITL  L TY+AGGLPLQ PD V + AD+L +YQ WQP    G  RLY+N SIGL G   + A G  +  LL   +L PLG++ T++ VP  A+S+YA GY    K VRVSPG LD E+YGVKS + DM  +   +M+P+R  + GAL + L+", "sequence_from_db": "MDAMVQTVMQAHQIPGMAIAIIQPGKTTYHNYGVASRETGQPVRETTLFEIGSLSKPFTALVAQRAETEGRIDLSAPASRYVAALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYQHWQPVHPAGTTRLYSNPSIGLMGLAASQATGESFAGLLGTTVLHPLGMNSTYLQVPPEARSRYAMGYTAAGKAVRVSPGPLDEETYGVKSTTADMAGFLLAHMDPAR--SKGALQSALQ", "sequence_from_broadstreet": "MKKRITPFSRFASKGLFACSAGMLLVTVAHAANTAAAPAGMDAMVQTVMQAHQIPGMAIAIIQPGKTTYHNYGVASRETGQPVRETTLFEIGSLSKPFTALVAQRAETEGRIDLSAPASRYVAALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYQHWQPVHPAGTTRLYSNPSIGLMGLAASQATGESFAGLLGTTVLHPLGMNSTYLQVPPEARSRYAMGYTAAGKAVRVSPGPLDEETYGVKSTTADMAGFLLAHMDPARSKGALQSALQQTRVPVYCAGQTRQGLGWESYQDWKNLDVLLAGNSNQMVFEPQPVKACPAGTMNDPDVWVNKTGSTAGFGAYAVFLPARQTGIVILANRNFPIADRIRLAHGILTALH", "dna_sequence_from_broadstreet": "ATGAAAAAACGGATTACCCCATTTTCCCGCTTTGCATCAAAAGGCCTTTTCGCCTGTAGCGCAGGCATGTTGCTGGTGACGGTGGCACATGCTGCCAATACGGCAGCAGCACCAGCCGGCATGGATGCCATGGTACAAACCGTGATGCAGGCACACCAGATTCCGGGCATGGCCATTGCCATCATCCAGCCAGGAAAGACCACTTATCACAATTATGGTGTCGCCTCCCGCGAAACCGGCCAGCCGGTCCGGGAAACCACCCTGTTTGAAATCGGGTCCCTTTCCAAACCGTTTACTGCACTGGTCGCCCAGCGGGCTGAAACCGAAGGCCGGATTGACCTGTCTGCACCGGCCAGCCGCTACGTTGCCGCCCTGCGAGGCAGTGCATTCGACCGGATCACCCTCAGGCAGCTCGGTACTTATAGCGCAGGCGGATTACCGCTCCAGTTTCCTGACAATGTCACCACCCCGGCAGACGTGCTGGCTTATTACCAGCATTGGCAACCTGTCCATCCGGCAGGTACCACCCGGCTGTATTCCAATCCGAGCATTGGCCTGATGGGGCTGGCTGCCAGTCAGGCAACCGGAGAGTCCTTTGCCGGCCTGCTCGGGACAACGGTGCTGCACCCCCTCGGCATGAACTCGACCTATCTGCAAGTGCCCCCGGAGGCCCGTTCACGTTATGCCATGGGATATACCGCCGCCGGAAAAGCGGTCAGGGTCAGCCCCGGTCCGCTGGATGAGGAAACCTACGGCGTCAAGTCCACAACCGCAGACATGGCCGGATTTTTATTGGCGCATATGGACCCTGCGCGCAGCAAAGGTGCATTGCAGTCGGCATTACAGCAAACACGTGTACCGGTTTATTGCGCCGGACAGACCCGGCAAGGACTGGGCTGGGAAAGTTATCAAGACTGGAAAAACCTAGACGTGCTGCTGGCGGGAAATTCAAATCAAATGGTGTTTGAGCCGCAGCCGGTAAAAGCCTGTCCTGCCGGCACCATGAATGATCCTGATGTGTGGGTCAACAAGACCGGTTCTACTGCGGGATTCGGCGCTTATGCCGTATTCCTGCCTGCCCGACAGACCGGCATTGTCATCCTGGCCAACCGTAATTTCCCGATTGCAGACCGTATCCGGCTCGCTCACGGGATTTTGACCGCATTGCACTGA", "partial": "0", "query_start": 1936, "query_end": 2664, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 44.67}, "gnl|BL_ORD_ID|2522|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2365", "ARO_accession": "3003882", "ARO_name": "ADC-76", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.18942e-63, "max_identities": 104, "bit_score": 202.216, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY   L       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKVLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGESRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKVLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGESRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACCCCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGTGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATCCAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGTGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGTATTAAGGCAGCGTATGCAGTTTTAAATGCAATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2435|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2353", "ARO_accession": "3003867", "ARO_name": "ADC-23", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.49566e-63, "max_identities": 105, "bit_score": 201.83, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        V  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  + AK +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I  PL L ++++ VP++    YAYGY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKIVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKIVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPASLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGAACAAGAAGTTAAAAAACTGGTAGATCAAAATTTTAAGCCTTTATTAGATAAATATGATGTGCCTGGTATGGCCGTGGGGGTCATTCAAAATAATAAAAAATATGAAATATATTATGGCCTACAATCCGTTCAGGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAACTAGGTTCGGTCAGTAAATTATTTACCGCTACAGCTGGTGGATATGCAAAAGCAAAAGGAAAAATCTCTTTTGATGACACACCCGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAATCTTCTTCAACTTGCGACGTATACAAGTGGCAATCTCGCCTTACAATTTCCAGATGAAGTTCAAACAGACCAACAAGTTTTAACTTTTTTCAAAGATTGGAAAACTAAAAACGCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAATTGTGGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTAGAAAAAACAATTTTTCCACCTCTCCATTTAAAAAATAGCTATGTAAATGTACCTAAAACTCAAATGCAAAATTATGCATATGGCTATAACCAAGAAAATCAGCCGATCCGAGTTAACCCTGGTCCGCTAGATGCCCCTGCGTACGGCGTTAAATCGACACTACCAGATATGCTGACTTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGTACGATGTATCAAGCATTGGGTTGGGAAGAATTTTCTTATCCAGCGTCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2516|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-43", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2359", "ARO_accession": "3003874", "ARO_name": "ADC-43", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.54435e-63, "max_identities": 104, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPLK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPLKYPKDIQRAINETHKGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCCCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTCGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAATTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAATTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCTGCATACGGCGTTAAATCGACACTACCAGACATGCTGAGTTTTATTAATGCCAACCTCAACCCACTGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATAAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCCTTGGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCTATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2430|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2348", "ARO_accession": "3003862", "ARO_name": "ADC-18", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.48574e-63, "max_identities": 105, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        V  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  + AK +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I  PL L ++++ VP++    YAYGY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQKYPKDIQRAISETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGAACAAGAAGTTAAAAAACTGGTAGATCAAAATTTTAAGCCTTTATTAGATAAATATGATGTGCCTGGTATGGCCGTGGGGGTCATTCAAAATAATAAAAAATATGAAATATATTATGGCCTACAATCCGTTCAGGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAACTAGGTTCGGTCAGTAAATTATTTACCGCTACAGCTGGTGGATATGCAAAAGCAAAAGGAAAAATCTCTTTTGATGACACACCCGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAATCTTCTTCAACTTGCGACGTATACAAGTGGCAATCTCGCCTTACAATTTCCAGATGAAGTTCAAACAGACCAACAAGTTTTAACTTTTTTCAAAGATTGGAAAACTAAAAACGCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTGGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTAGAAAAAACAATTTTTCCACCTCTCCATTTAAAAAATAGCTATGTAAATGTACCCAAAACTCAAATGCAAAATTATGCATATGGCTATAACCAAGAAAATCAGCCGATCCGAGTTAACCCTGGCCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGATATGCTGACTTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAGTGAAACACATCAAGGTTTCTATCAAGTCGGTACGATGTATCAAGCATTGGGTTGGGAAGAATTTTCTTATCCAGCACCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2512|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2347", "ARO_accession": "3003861", "ARO_name": "ADC-17", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.14506e-63, "max_identities": 103, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+   +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDRQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNRENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDRQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNRENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCTCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTGTTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATTTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACGCCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCGACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCCTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCGAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACACACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGTTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|2433|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2351", "ARO_accession": "3003865", "ARO_name": "ADC-21", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.24334e-63, "max_identities": 104, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKLKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKLKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSIKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGTGTTATTCAGAATAATAAAAAGTATGAAATGTATTATGGTCTACAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACTTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTGGGATTAAAACATAGTTATGTAAATGTGCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACCCTACCTGATATGCTGAGTTTCATTAATGCCAATATAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAATTAAGATGTTCCACAAAACTGGTTCGACTAACGGTTTTGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCGAATGAAGAACGCATTAAAGCAGCTTATGCTGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2526|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2370", "ARO_accession": "3003887", "ARO_name": "ADC-81", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.76089e-63, "max_identities": 106, "bit_score": 201.445, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLD-----AESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LD     A +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.41}, "gnl|BL_ORD_ID|2434|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2352", "ARO_accession": "3003866", "ARO_name": "ADC-22", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44808e-62, "max_identities": 103, "bit_score": 201.06, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+   +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCTCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGCACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATTTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACACACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|2517|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-44", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2360", "ARO_accession": "3003876", "ARO_name": "ADC-44", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.72035e-62, "max_identities": 103, "bit_score": 200.29, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGF----SAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   +    S    +  +VD   KPL+ + ++PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTSKEQEIKKLVDQNFKPLLDKYNVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTSKEQEIKKLVDQNFKPLLDKYNVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSIKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCCCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACATCAAAAGAACAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATAATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTTAGTAAATTATTTACCGCGACAGCAGGTGGATATGCCAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTTGCTACCTATACAAGTGGCAACCTTGGCTTACAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAGCCTAAAAACTCAATCGGTGAATATCGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCATTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGTTAGATGCACCTGCGTACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAATTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCATATGCGGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|1806|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1912", "ARO_accession": "3002484", "ARO_name": "LRA-13", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "41405": {"category_aro_accession": "3004241", "category_aro_cvterm_id": "41405", "category_aro_name": "class D LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09654e-61, "max_identities": 97, "bit_score": 204.142, "cvterm_id": "39085", "query": "PGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN-KKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "PG    D    +VD  ++PLM + DIPGMAVAV+  GK Y+FNYG A  +  Q VT +TLFE+GS+SKT    L + +    ++AL D  +++ P+L    +  I+LL+L T+TAG  P+QVPD +++   L+ +Y+ W+P    G  R Y+N ++GL G +TA + GMP+ + +  R+   LG+ H++I VP +    YA GY     PVR++P  L  E+YGVK+ + D++R+ + NM", "sequence_from_db": "PGLMIKD----MVDRAVQPLMKKYDIPGMAVAVTDNGKNYFFNYGLASRETGQAVTSHTLFEIGSLSKTMAATLTSYAQVNGQLALTDTVSRHMPKLRGGGFDKISLLNLGTHTAGDFPMQVPDHIETYEQLMEYYKNWKPGVAAGGARTYSNLTVGLLGIITAQSMGMPFAEAMENRLFPQLGMHHSYINVPAAEMKNYAQGYNQANAPVRINPAVLATEAYGVKTDAADLIRFVDANM", "sequence_from_broadstreet": "MNFRHIVMAALCGLAWTPAIHATEVCIAIAEAGTGAVLVQRGDCQRQVTPASTFKIAISLMGYDSGFLKDAHAPKLPFRPGYVDWRPSWREPTDPAKWMSDSVVWYSQQVTKSLGMQRFADYTRNFKYGNADVSGDAENDGLSMSWISSSLRISPLEQLAFLDKIVNRRLGVSAHAYDMTAQLTKFDQPPAGWRINGKTGAASGYGWYVGWASKGSRTFVFAHLMQRDATQPQDVSAGVLARDEFLKELPGLMIKDMVDRAVQPLMKKYDIPGMAVAVTDNGKNYFFNYGLASRETGQAVTSHTLFEIGSLSKTMAATLTSYAQVNGQLALTDTVSRHMPKLRGGGFDKISLLNLGTHTAGDFPMQVPDHIETYEQLMEYYKNWKPGVAAGGARTYSNLTVGLLGIITAQSMGMPFAEAMENRLFPQLGMHHSYINVPAAEMKNYAQGYNQANAPVRINPAVLATEAYGVKTDAADLIRFVDANMGLVKLDEKLQRAVTGTHTAYFKTGELTQDLIWEQYPAASKLDRMLAGVSEKMVFESNPATRLAPPMPPQADVLINKTGSTGGFGAYALFNPGKKTGIVMLANKSYPGAERVTAAWHILDQLDQR", "dna_sequence_from_broadstreet": "ATGAATTTTCGCCACATAGTCATGGCGGCGCTGTGCGGTCTCGCCTGGACGCCAGCCATCCACGCCACCGAAGTGTGTATCGCCATCGCCGAGGCCGGCACCGGCGCTGTGCTGGTCCAGCGCGGCGATTGCCAGCGCCAGGTGACGCCGGCGTCGACCTTCAAGATCGCCATCAGCCTGATGGGCTACGACTCGGGTTTTCTGAAGGACGCGCACGCGCCGAAACTGCCGTTCCGTCCAGGCTATGTCGATTGGCGGCCCAGCTGGCGCGAACCGACGGATCCGGCCAAGTGGATGAGCGATTCGGTCGTATGGTATTCGCAGCAGGTGACAAAATCCCTGGGCATGCAGCGTTTCGCCGACTACACGCGGAACTTCAAGTATGGCAATGCCGACGTTTCGGGGGACGCGGAAAATGACGGCCTGAGCATGTCGTGGATAAGTTCCTCGCTGCGGATCTCGCCGCTGGAACAACTCGCGTTCCTGGACAAGATCGTCAACCGTCGGCTGGGCGTGAGCGCCCATGCCTACGACATGACCGCGCAATTGACGAAATTCGATCAGCCTCCGGCGGGATGGCGCATCAACGGCAAGACCGGCGCCGCCTCCGGTTATGGCTGGTACGTGGGATGGGCGTCGAAAGGTTCGCGAACCTTCGTCTTTGCGCACCTGATGCAGAGGGACGCGACGCAGCCGCAAGACGTGTCGGCGGGCGTGCTGGCGCGTGACGAATTCCTCAAGGAACTCCCCGGCTTGATGATCAAGGATATGGTGGACCGCGCCGTCCAGCCGTTGATGAAGAAATACGATATCCCGGGGATGGCGGTGGCCGTCACCGACAACGGCAAGAACTACTTCTTCAACTACGGGCTGGCGTCGAGGGAAACCGGGCAAGCCGTTACCAGCCACACCCTGTTCGAGATCGGTTCGCTGAGCAAGACCATGGCGGCAACGCTGACTTCCTACGCGCAGGTCAACGGCCAGCTTGCGTTGACCGACACGGTCAGCCGGCATATGCCCAAGCTGCGCGGCGGCGGCTTCGACAAGATCAGCCTGCTCAATCTGGGCACCCACACGGCCGGCGATTTTCCGATGCAGGTTCCCGACCATATCGAGACCTACGAGCAGCTGATGGAGTACTACAAAAACTGGAAGCCCGGGGTTGCTGCGGGCGGCGCCAGGACCTACTCCAACCTGACCGTCGGCCTGCTGGGCATCATCACGGCGCAAAGCATGGGCATGCCGTTTGCGGAGGCGATGGAAAACAGGTTGTTCCCCCAGCTTGGCATGCATCACAGCTATATCAATGTGCCGGCGGCGGAGATGAAGAACTACGCGCAAGGCTACAACCAGGCCAACGCACCGGTCAGGATCAATCCGGCGGTGCTGGCAACCGAGGCATACGGGGTAAAGACCGATGCCGCCGACTTGATCCGGTTTGTCGACGCCAACATGGGGTTGGTCAAGCTGGACGAAAAACTGCAGCGCGCGGTCACCGGCACGCACACCGCCTACTTCAAGACGGGTGAGCTGACGCAGGATCTGATCTGGGAACAATATCCCGCCGCATCGAAACTCGATCGCATGCTGGCGGGCGTTTCCGAAAAAATGGTCTTTGAAAGCAATCCCGCGACCAGGCTGGCGCCGCCGATGCCGCCGCAAGCGGATGTGCTGATCAACAAGACCGGATCAACCGGCGGCTTTGGCGCCTATGCGCTGTTCAACCCGGGCAAGAAGACCGGCATCGTGATGCTGGCGAACAAGAGCTATCCTGGCGCAGAAAGGGTGACGGCGGCCTGGCACATACTGGATCAACTGGACCAGCGTTAG", "partial": "0", "query_start": 1900, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.42}, "gnl|BL_ORD_ID|2129|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3314", "ARO_accession": "3003855", "ARO_name": "ADC-10", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.22685e-61, "max_identities": 105, "bit_score": 198.749, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDA-----ESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA      +YGVKS   DML +   N+ P  ", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLERYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVPAYGVKSTLPDMLSFIHANLNPQE", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLERYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVPAYGVKSTLPDMLSFIHANLNPQEYPADIQRAINETHQGFYQANTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVTLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAGATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTGTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGGAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGCAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCACGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.03}, "gnl|BL_ORD_ID|1336|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1422", "ARO_accession": "3001817", "ARO_name": "ACC-3", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.77255e-59, "max_identities": 99, "bit_score": 191.43, "cvterm_id": "36784", "query": "MKKSLSATL----ISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+K +  TL    +   LA +A G  A++     +   VDS I+PLM + +IPGM+VAV++ GK Y +NYG A  Q +QPVT+NTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  I++L+  T+T  GL L +P+ VK+   L+ + + W+P+   G  R+Y+N   GL G + A + GM YE  +   +L  LG++HT++ VP      YA+GY K  +P+ V+   L  E+YG+++ + D++R+ + NM", "sequence_from_db": "MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKNNIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTT-GLALFMPEEVKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAIEKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGIRTNASDLIRYVQANM", "sequence_from_broadstreet": "MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKNNIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEEVKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAIEKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGIRTNASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWEQLPYPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVT", "dna_sequence_from_broadstreet": "ATGCGTAAAAAAATGCAGAACACCTTGAAGATGTTATCCGTGATTACCTGTCTGGCTTTAACGGCTCAGGGTGCCATGGCGTCAGAAATGGATCAGGCCAAAATTAAAGACACCGTTGATAGCCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCGGGCATGTCGGTGGCAGTTACGCTGAACGGTAAAAATTATATTTATAACTATGGCTTAGCCTCCAAACAGCCCCAGCAGCCCGTAACGGACAACACGCTATTTGAAGTTGGCTCGCTGAGCAAAACCTTTGCAGCGACGCTGGCGTCTTATGCACAGGTCAGCGGCAAGTTATCGCTGGATAAAAGCATTAGCCATTATGTTCCAGAACTGCGCGGCAGCAGCTTCGATCACATTAGCGTGCTGAATGCGGGAACGCATACCACAGGTTTAGCGCTGTTCATGCCTGAAGAAGTGAAAAACACCGATCAGCTGATGGCTTATCTGAAAGCGTGGAAACCCGCCGATCCTGCGGGGACTCACCGTGTTTATTCCAATATTGGTACCGGCTTGTTGGGCATGATTGCCGCGCAAAGCATGGGAATGACTTACGAAGATGCGATTGAGAAAACGCTCCTTCCGAAGTTGGGCATGACGCACACCTATCTTAATGTTCCAGCAGACCAAGCGGAAAATTATGCTTGGGGCTATAACAAAAAGAATGAGCCGATCCACGTTAATATGGAAGTGTTGGGCAACGAAGCCTATGGCATTAGAACCAATGCGAGTGACCTGATTCGCTATGTGCAAGCCAATATGGGGCAGCTAAAACTTGATGGAAATTCGACGCTGCAAAAAGCGCTCACCGACACGCATATCGGTTACTTCAAGTCAGGCAAAATCACTCAGGATCTGATGTGGGAACAGCTGCCATATCCGGTATCTCTGCCGGATCTGCTCACTGGCAACGATATGGCGATGACAAAAAGCGTTGCTACGCCGATTGTTCCACCGCTGCCACCACAGGAAAATGTATGGATTAACAAAACCGGTTCCACCAATGGTTTTGGTGCCTACATCGCATTTGTTCCGGCTAAAAAGATGGGTATCGTGATGCTGGCGAACAAGAACTACTCTATCGATCAGCGTGTAACG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.22}, "gnl|BL_ORD_ID|1569|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1663", "ARO_accession": "3001815", "ARO_name": "ACC-1", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.2332e-58, "max_identities": 98, "bit_score": 190.66, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+ +L    +   LA +  G  AA+     +   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.4}, "gnl|BL_ORD_ID|1909|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2024", "ARO_accession": "3001816", "ARO_name": "ACC-2", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.58333e-58, "max_identities": 91, "bit_score": 189.504, "cvterm_id": "36784", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+PLM + +IPGM+VAV+++G+ Y +NYG A  Q +QPVTENTLFE+GS+SKTF  +L + + A  +++L    + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   IL  LG++ T++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "IKDTVDGLIQPLMQKNNIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MRKKMQNTLKLLSVITCLAATAQGAMAANIDESKIKDTVDGLIQPLMQKNNIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDGNAKIQHALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEVNK", "dna_sequence_from_broadstreet": "ATGCGTAAAAAAATGCAGAACACCTTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGCCCAAGGTGCTATGGCTGCCAATATCGATGAGAGCAAAATTAAAGACACCGTCGATGGCCTAATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCATCAGAGGTAGGAACTATATTTATAACTACGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTGACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCATCTTGGCGTCCTATGCGCAGGCGAGCGGTAAGCTGTCTTTGGAGCAAAGCGTTAGCCACTATGTTCCAGAACTACGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGTACGCATACCTCAGGTCTACAGCTGTTTATGCCGGAAGATATCAAGAACACCACACAGCTGATGACTTATCTAAAAGCATGGAAACCTGCTGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACCGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGCAAACCATCCTTCCTCTATTAGGCATGAATCAAACCTACCTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTCAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGGTAATGCCAAGATCCAACATGCACTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCAGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCCCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAACGAGTGACGGTGGCGTATAAAATCCTGAGCTCGTTGGAAGTGAATAAGTAG", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.22}, "gnl|BL_ORD_ID|376|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "406", "ARO_accession": "3001818", "ARO_name": "ACC-4", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.94289e-57, "max_identities": 97, "bit_score": 187.578, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+ +L    +   LA +  G  AA+     +   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV  +   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGGGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.02}, "gnl|BL_ORD_ID|1762|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1865", "ARO_accession": "3001819", "ARO_name": "ACC-5", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.32808e-57, "max_identities": 91, "bit_score": 187.578, "cvterm_id": "36784", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "IKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQLSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATAQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQLSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGCCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGTTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGTGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACTGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCCCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.22}, "gnl|BL_ORD_ID|2506|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Rhodobacter sphaeroides ampC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2844", "ARO_accession": "3004291", "ARO_name": "Rhodobacter sphaeroides ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "36976": {"category_aro_accession": "3000632", "category_aro_cvterm_id": "36976", "category_aro_name": "benzylpenicillin", "category_aro_description": "Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.28114e-54, "max_identities": 95, "bit_score": 178.333, "cvterm_id": "41456", "query": "LMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKK--PVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "++ + DIPG+ V V+  G+  ++  G A  + +QPVT +TLFELGS+SK F   L A++  +  ++L+ P A Y P L       +TL+DLAT+  GGLPLQVPD V     L+++ + W+P  +PG  R Y+N SIGL G +TA   GM Y       I   LGL  T+I VP  A  +YA+GY  K   P RV+PG LD E+YGVKS+++DML   ++ +", "sequence_from_db": "VIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPP-EPG-TRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEAYGVKSSARDMLTLLDLEL", "sequence_from_broadstreet": "MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPPEPGTRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEAYGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEVDTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRNYPNEARVRATYDLITHILAE", "dna_sequence_from_broadstreet": "ATGAAGCACCTTTCCCCCCTCTCCATCCTGCTCATGGTGGGCGCGCTGACGCCCGCGCTTGCGCAAGACACCACGCCGTCGTTCGAGAGCGCCGCCGCCGCGGCCTTCGAGAGCGTCATCGAGGAGCATGACATTCCCGGTCTGGTGGTGGGCGTGACCCACGGCGGACGGCACAGTTTCTATCAGACAGGCTTGGCCTCACGGGAAGATCAGCAGCCGGTAACCCCTGACACGCTTTTTGAGCTCGGTTCGATCAGCAAGATCTTCAACGTGACGCTGGCGGCCTTGGCAGAGGAGCGGGGCGCGCTGTCGCTCGATGCGCCGGTCGCCGACTATCTTCCCTCCCTGCGAGGTTCTCCTGCAGGAGAGCTGACGCTGATCGATCTGGCGACGCACCATACCGGCGGCCTCCCGTTGCAGGTGCCGGACGAAGTTGCAGATGTAGATCGCCTGGTCGACTGGCTACGGAGTTGGCGACCGCCCGAGCCCGGTACGCGCAGCTATTCCAACATCAGCATCGGCCTATTGGGGCACATCACCGCGGGCGTGCTGGGCATGAGCTATGCTGATGCGTCCCAGACGGTTATCTTCCCGGCGCTCGGATTGAAGAGCACGTGGATCGACGTCCCCACCGATGCGATGGGACGCTACGCCTTCGGCTATGACCGCAAGACAGACGCGCCAACCCGGGTTACGCCCGGCGTGCTGGACGATGAAGCGTACGGGGTAAAATCCTCCGCTCGCGACATGCTGACGCTGCTCGACCTCGAGCTTGGAACCGGCACTGCCTCGCCCGAAGTTCAAACGGCGGTGGCCACCACGCAGGAGGGCCGGTTCCAGACCCGCCTGTACACGCAGGCCATGATATGGGAGGCCTATCCTTGGCCTGTCGACCCAGAGCGTCTGGTGGAGGGGAACGGGTATGACTTCATCCTCCAGCCTCAGCCTGTGGACGAGGTGGACACGACACCCGATCGGAGGGTCATCCTGAACAAGACAGGTTCCACGAACGGCTTCGGTGGGTACATCGCGATCGTGCCAAGCGAGGATCTGGGCGTCGTCGTCCTTGCCAACCGCAACTACCCCAACGAGGCGCGGGTTCGAGCCACTTACGACCTGATCACTCACATCTTGGCCGAATAA", "partial": "0", "query_start": 1957, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.79}, "gnl|BL_ORD_ID|2080|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3307", "ARO_accession": "3004612", "ARO_name": "Escherichia coli ampH beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.90189e-13, "max_identities": 72, "bit_score": 67.0106, "cvterm_id": "42578", "query": "MKKSL--SATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELA-LPQWKG--ITLLDLATYTAGGLPLQVPDAVKSRADLL--NFYQQWQ------PSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAE", "match": "MK+SL  SA L +A L    +A   +  +  + +VD     +       GMA+ V    +  + +YG            +++  + S++K  T  +    + +  + LNDP +KY P  A +P + G  ITL++LAT+T+  LP + P     R   +     Q+W+          PG    Y+N +  L     ANA+G PY QL   +I  PLG+  T  T       +     +   P   +   +   S GV S   DM+RW +", "sequence_from_db": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSA-LPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIG--SGGVYSTPGDMMRWMQ", "sequence_from_broadstreet": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "dna_sequence_from_broadstreet": "TTGAAACGTAGTCTGCTTTTTTCTGCCGTGCTGTGTGCGGCGTCATTGACCTCCGTCCATGCGGCGCAGCCGATCACTGAACCGGAGTTTGCCTCTGATATTGTCGATCGTTATGCCGATCATATTTTTTACGGCAGCGGTGCCACGGGGATGGCTCTGGTTGTTATCGACGGTAACCAGCGCGTCTTTCGCAGTTATGGCGAAACGCGACCTGGTAATAACGTTCGCCCGCAGCTGGATTCGGTCGTGCGTATTGCTTCCCTCACCAAGCTAATGACCAGTGAGATGCTGGTGAAATTGCTCGACCAGGGGACCGTGAAGTTAAACGATCCGCTAAGTAAATATGCTCCGCCAGGCGCACGCGTGCCAACCTACAATGGGACGCCCATTACGCTGGTCAATCTGGCAACCCATACCAGCGCCCTGCCCCGTGAACAGCCCGGTGGCGCGGCACATCGTCCGGTGTTTGTCTGGCCAACGCGCGAGCAACGCTGGAAATACCTTTCTACGGCGAAGCTGAAAGCCGCGCCAGGCAGTCAGGCGGCGTACTCTAACCTTGCGTTCGACCTGCTGGCAGATGCACTGGCGAATGCGTCCGGCAAGCCTTATACCCAGTTGTTTGAAGAGCAGATTACCCGTCCATTGGGGATGAAAGACACCACCTACACCCCCTCACCGGATCAGTGCCGCCGTTTAATGGTTGCTGAGCGCGGTGCCAGTCCGTGCAATAACACGCTGGCGGCAATTGGCAGCGGCGGCGTCTATTCCACGCCTGGCGATATGATGCGCTGGATGCAGCAGTATTTGTCATCTGATTTTTATCAGCGCAGTAACCAGGCAGATCGCATGCAGACGTTGATTTATCAGCGCGCGCAGTTTACGAAAGTGATTGGCATGGATGTCCCCGGCAAAGCGGATGCGCTTGGTTTAGGTTGGGTATATATGGCCCCGAAAGAGGGTCGTCCGGGGATTATTCAGAAGACAGGCGGTGGTGGCGGTTTCATTACCTATATGGCGATGATCCCGCAGAAGAATATTGGCGCGTTTGTGGTGGTCACTCGTTCGCCGTTGACGCGCTTTAAAAATATGAGCGATGGCATCAATGACCTGGTGACCGAGCTAAGCGGGAATAAACCGTTGGTTATCCCCGCGTCCTGA", "partial": "0", "query_start": 1846, "query_end": 2607, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 26.77}, "gnl|BL_ORD_ID|1968|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC1 beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3306", "ARO_accession": "3004611", "ARO_name": "Escherichia coli ampC1 beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.000134295, "max_identities": 39, "bit_score": 39.6614, "cvterm_id": "41021", "query": "KQPV--TENTLFELGSVSKTF-TGVLGAVSVAKKEMALNDPAAKYQPELAL---PQWKGITLLDLAT--YTAGGLPL--QVPDAV-------KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHT", "match": "+QPV  T  TL++L S +K + T       +++ ++  +D  AKY P  A       KG   L ++   + +GG P   Q P+         + +   L   ++     +PG   +Y++    L G +  +  G P ++ +   I  PLGL+HT", "sequence_from_db": "EQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHT", "sequence_from_broadstreet": "MKRTMLYLSLLAVSCSVSAAKYPVLTESSPEKAGFNVERLNQMDRWISQQVDVGYPSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHTVFNPLLKGFKPQQIAATELNGNTRDGVIHFPNIRTSTLWGQVHDEKAFYSMGGVSGHAGLFSNTGDIAVLMQTMLNGGGYGDVQLFNAETVKMFTTSSKEDATFGLGWRVNGNATMTPTFGTLASPQTYGHTGWTGTVTVIDPVNHMTIVMLSNKPHSPVADPQKNPNMFESGQLPIATYGWVVDQVYAALKQK", "dna_sequence_from_broadstreet": "ATGAAACGGACAATGCTCTATCTTTCTCTGCTGGCTGTTAGTTGTAGCGTCAGCGCCGCAAAATACCCTGTTCTGACAGAAAGCTCGCCAGAGAAAGCAGGGTTTAACGTCGAACGGCTTAACCAGATGGATCGCTGGATTAGCCAGCAAGTTGATGTCGGTTATCCCAGCGTAAACCTGCTGATCATTAAAGATAATCAGATTGTGTATCGCAAAGCCTGGGGAGCGGCGAAAAAGTACGATGGCAGCGTGTTGATGGAACAGCCTGTCAAAGCCACCACCGGGACGCTGTATGACCTGGCCTCAAACACCAAAATGTACGCCACGAACTTCGCCCTGCAAAAGCTGATGAGCGAAGGCAAACTGCATCCTGACGATCGGATTGCGAAATATATTCCGGGGTTTGCCGATAGTCCAAATGACACCATTAAAGGCAAAAACACCCTGCGGATTTCTGACCTGCTGCATCACAGCGGCGGTTTCCCGGCAGATCCGCAATACCCGAATAAAGCGGTCGCGGGCGCGTTATATTCCCAGGATAAAGGCCAGACGCTGGAGATGATCAAGCGCACGCCGCTGGAATATCAGCCCGGCAGCAAACATATCTACAGCGATGTCGATTATATGCTGCTTGGATTTATCGTCGAGTCGGTTACCGGTCAGCCGCTTGACCGCTATGTTGAAGAGTCGATTTATCGCCCGCTCGGCCTGACACATACGGTATTTAACCCGCTGCTGAAAGGCTTTAAACCGCAACAAATTGCCGCCACGGAATTGAACGGCAATACCCGCGATGGCGTGATCCATTTCCCGAATATCCGCACCTCCACTCTCTGGGGTCAGGTGCACGATGAAAAAGCCTTTTATTCGATGGGCGGCGTTTCCGGGCACGCAGGTTTGTTTTCCAATACCGGCGATATTGCGGTGTTAATGCAAACGATGCTGAACGGCGGGGGCTATGGTGATGTGCAGCTGTTCAATGCGGAAACGGTGAAGATGTTCACCACCAGCTCTAAGGAAGATGCCACTTTTGGCCTCGGCTGGCGCGTGAATGGTAATGCCACCATGACGCCGACGTTTGGCACGCTGGCAAGCCCGCAAACCTACGGTCACACTGGCTGGACCGGAACGGTGACCGTTATCGATCCGGTGAATCATATGACGATTGTGATGTTAAGCAACAAGCCACATTCGCCGGTTGCCGATCCGCAAAAGAATCCCAATATGTTCGAAAGCGGTCAGTTGCCGATTGCAACTTATGGTTGGGTAGTTGATCAGGTGTATGCGGCGTTAAAGCAGAAGTAA", "partial": "0", "query_start": 2053, "query_end": 2463, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 25.32}, "gnl|BL_ORD_ID|712|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OXA-198", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "758", "ARO_accession": "3001805", "ARO_name": "OXA-198", "ARO_category": {"36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0309057, "max_identities": 38, "bit_score": 31.9574, "cvterm_id": "36752", "query": "MKKSLSATLISALLAF--SAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVK-GKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPEL-ALPQW", "match": "M K +S   I A LAF  S P        AA  D T+  L AQQ I G  V  S+  GK +  N    D +AKQ           S + TF  +   +S+ +K ++  D   K+   +   P W", "sequence_from_db": "MHKHMSKLFI-AFLAFLLSVP--------AAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHN----DPRAKQRF---------STASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDW", "sequence_from_broadstreet": "MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE", "dna_sequence_from_broadstreet": "ATGCATAAACACATGAGTAAGCTCTTCATCGCTTTTTTAGCCTTTCTGCTGTCGGTGCCAGCAGCCGCTGAAGACCAGACACTTGCCGAGCTCTTTGCCCAACAAGGCATTGACGGGACTATAGTGATTTCGTCGCTACACAACGGAAAGACATTTATCCACAACGATCCCCGCGCAAAACAGAGATTCTCGACAGCATCCACGTTCAAGATACTGAACACGCTGATCTCGCTCGAAGAAAAAGCCATCTCTGGAAAAGACGATGTGCTGAAATGGGACGGGCATATTTACGATTTTCCAGATTGGAATCGTGACCAGACGCTAGAAAGTGCGTTCAAGGTTTCCTGTGTCTGGTGTTATCAGGCGCTTGCACGCCAGGTCGGCGCGGAGAAGTATCGAAATTATTTACGCAAGTCAGTTTACGGAGAATTACGCGAGCCTTTTGAGGAAACAACATTCTGGCTTGATGGTTCACTTCAAATCAGCGCAATTGAACAAGTGAATTTCCTCAAGAAAGTTCATCTGCGCACTCTCCCATTCAGTGCATCGTCCTACGAAACGCTACGACAAATCATGCTTATCGAGCAAACGCCGGCTTTTACGCTGCGGGCCAAGACAGGCTGGGCAACAAGAGTAAAGCCGCAAGTTGGCTGGTATGTGGGCCATGTCGAAACTCCAACGGATGTATGGTTCTTTGCCACGAATATTGAAGTCCGTGACGAAAAAGACTTGCCCTTACGTCAGAAGCTAACGCGAAAAGCATTACAAGCAAAGGGGATCATCGAATAA", "partial": "0", "query_start": 1846, "query_end": 2205, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 30.65}}, "NODE_47_length_3813_cov_27.9457_4 # 2763 # 3638 # -1 # ID=47_4;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.550": {"gnl|BL_ORD_ID|1919|hsp_num:0": {"type_match": "Perfect", "model_id": "2035", "orf_strand": "-", "orf_start": 2763, "orf_end": 3638, "orf_from": "NODE_47_length_3813_cov_27.9457_4", "model_name": "CTX-M-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3001878", "ARO_name": "CTX-M-15", "ARO_category": {"36025": {"category_aro_accession": "3000016", "category_aro_cvterm_id": "36025", "category_aro_name": "CTX-M beta-lactamase", "category_aro_description": "These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime.  CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 593.578, "max_identities": 291, "cvterm_id": "35914", "query": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "match": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "sequence_from_db": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "sequence_from_broadstreet": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "dna_sequence_from_broadstreet": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "partial": "0", "query_start": 2763, "query_end": 3635, "orf_dna_sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "orf_prot_sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "perc_identity": 100.0}}, "NODE_51_length_1731_cov_22.5767_1 # 196 # 1026 # 1 # ID=51_1;partial=00;start_type=ATG;rbs_motif=ATA;rbs_spacer=6bp;gc_cont=0.345": {"gnl|BL_ORD_ID|1846|hsp_num:0": {"type_match": "Perfect", "model_id": "1952", "orf_strand": "+", "orf_start": 196, "orf_end": 1026, "orf_from": "NODE_51_length_1731_cov_22.5767_1", "model_name": "OXA-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3001396", "ARO_name": "OXA-1", "ARO_category": {"35994": {"category_aro_accession": "0000077", "category_aro_cvterm_id": "35994", "category_aro_name": "tazobactam", "category_aro_description": "Tazobactam is a compound which inhibits the action of bacterial beta-lactamases.", "category_aro_class_name": "Adjuvant"}, "36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "40951": {"category_aro_accession": "3004021", "category_aro_cvterm_id": "40951", "category_aro_name": "piperacillin-tazobactam", "category_aro_description": "An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 564.303, "max_identities": 276, "cvterm_id": "35915", "query": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "match": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "sequence_from_db": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "sequence_from_broadstreet": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA", "partial": "0", "query_start": 196, "query_end": 1023, "orf_dna_sequence": "ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA", "orf_prot_sequence": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "perc_identity": 100.0}}, "NODE_51_length_1731_cov_22.5767_2 # 1164 # 1712 # 1 # ID=51_2;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.494": {"gnl|BL_ORD_ID|134|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "150", "ARO_accession": "3002676", "ARO_name": "catB3", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4043e-109, "max_identities": 147, "bit_score": 308.145, "cvterm_id": "36884", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "sequence_from_db": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "sequence_from_broadstreet": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKKIKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV", "dna_sequence_from_broadstreet": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGAGCCTTACGCTATCGTTGGCGGCAATCCCGCTAAGAAGATTAAGAAACGCTTCACCGATGAGGAAATTTCATTGCTTCTGGAGATGGAGTGGTGGAATTGGTCACTGGAGAAGATCAAAGCGGCAATGCCCATGCTGTGCTCGTCTAATATTGTTGGCCTGCACAAGTATTGGCTCGAGTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|413|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "446", "ARO_accession": "3002680", "ARO_name": "catB8", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05722e-89, "max_identities": 135, "bit_score": 257.299, "cvterm_id": "35731", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYF+SPFKG+LLSEQVKNPNI+VGRYSYYSGYYHGHSFD+CARYL PDRDDVDKLIIGSFCSIGSGASFIMAGNQGHR+DWASSFPFFYMQEEPAFS ALDAFQ+AG+TVIGNDVWIGSEAM+MPGIKIG GAVIGSRSLVTKDV", "sequence_from_db": "MKNYFNSPFKGELLSEQVKNPNIRVGRYSYYSGYYHGHSFDECARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWASSFPFFYMQEEPAFSRALDAFQRAGDTVIGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTKDV", "sequence_from_broadstreet": "MKNYFNSPFKGELLSEQVKNPNIRVGRYSYYSGYYHGHSFDECARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWASSFPFFYMQEEPAFSRALDAFQRAGDTVIGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTKDVEPYAIIGGNPAKQIKKRFSDEEISLLMEMEWWNWPLDKIKTAMPLLCSSNIFGLHKYWREFAV", "dna_sequence_from_broadstreet": "ATGAAAAACTACTTTAACAGCCCTTTCAAAGGGGAACTTCTTTCTGAGCAAGTGAAAAATCCAAATATCAGAGTAGGCCGGTATAGCTATTACTCTGGCTACTATCACGGGCACTCATTTGATGAATGCGCGCGATACTTGCTTCCAGATCGTGATGACGTTGATAAATTGATCATTGGCAGCTTTTGTTCTATAGGAAGCGGGGCTTCCTTCATCATGGCTGGCAATCAGGGGCATCGGCATGACTGGGCATCATCCTTCCCCTTCTTCTATATGCAAGAGGAGCCTGCTTTCTCAAGAGCACTCGACGCCTTCCAAAGAGCAGGTGATACCGTCATTGGCAATGATGTCTGGATAGGCTCGGAGGCAATGATTATGCCTGGCATCAAAATTGGAGACGGTGCCGTGATAGGTAGTCGCTCGTTGGTGACAAAAGATGTAGAGCCTTATGCCATCATCGGGGGAAATCCCGCAAAGCAAATTAAGAAGCGCTTCTCCGATGAGGAAATCTCATTGCTCATGGAGATGGAGTGGTGGAACTGGCCACTAGATAAAATTAAGACAGCAATGCCTCTGCTGTGCTCGTCAAATATTTTTGGTCTGCATAAGTATTGGCGCGAGTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 91.84}, "gnl|BL_ORD_ID|669|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "712", "ARO_accession": "3002675", "ARO_name": "catB2", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.87251e-89, "max_identities": 131, "bit_score": 256.144, "cvterm_id": "36867", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYF+SPFKGKLL+EQVKNPNIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVD+LIIGSFCSIGSGA+FIMAGNQGHRYDW SSFPFFYM EEPAF+ ++DAFQ+AG+TVIG+DVWIGSEAM+MPGIKIGHGAVIGSR+LVTKDV", "sequence_from_db": "MTNYFESPFKGKLLTEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDQLIIGSFCSIGSGAAFIMAGNQGHRYDWVSSFPFFYMNEEPAFAKSVDAFQRAGDTVIGSDVWIGSEAMIMPGIKIGHGAVIGSRALVTKDV", "sequence_from_broadstreet": "MTNYFESPFKGKLLTEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDQLIIGSFCSIGSGAAFIMAGNQGHRYDWVSSFPFFYMNEEPAFAKSVDAFQRAGDTVIGSDVWIGSEAMIMPGIKIGHGAVIGSRALVTKDVEPYTIVGGNPAKSIRKRFSEEEISMLLDMAWWDWPLEQIKEAMPFLCSSGIASLYRRWQGTSA", "dna_sequence_from_broadstreet": "ATGACGAATTATTTTGAGAGTCCCTTCAAAGGGAAGCTTCTGACTGAGCAGGTGAAGAATCCGAACATCAAGGTAGGGCGGTATAGCTACTATTCCGGCTATTACCATGGGCACTCGTTTGATGATTGTGCTCGCTACCTTCTACCAGACCGTGATGACGTTGATCAGCTGATTATCGGCAGCTTCTGCTCCATCGGATCAGGCGCAGCTTTTATTATGGCTGGGAATCAAGGCCACCGATATGATTGGGTCTCTTCTTTCCCTTTCTTCTACATGAACGAGGAGCCCGCGTTTGCAAAATCAGTCGATGCATTCCAGCGGGCTGGCGACACAGTTATAGGAAGTGATGTGTGGATCGGTTCGGAGGCCATGATCATGCCCGGGATCAAGATCGGGCATGGAGCGGTGATAGGTAGCCGCGCTTTGGTTACCAAAGACGTGGAACCCTACACCATAGTGGGGGGAAACCCTGCAAAGTCGATTAGGAAGCGCTTTTCTGAAGAAGAAATTTCTATGCTTTTAGATATGGCTTGGTGGGATTGGCCGCTGGAACAAATCAAGGAAGCAATGCCTTTTCTTTGTTCGTCTGGCATTGCCAGCCTGTATCGTCGCTGGCAAGGCACAAGCGCCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 89.12}, "gnl|BL_ORD_ID|586|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "628", "ARO_accession": "3003110", "ARO_name": "catB10", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.63679e-88, "max_identities": 129, "bit_score": 253.447, "cvterm_id": "36752", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYF+SPFKGKLL++QVKNPNIKVGRYSYYSGYYHGHSFD+CAR+L PDRDD+D+LI+GSFCSIG+GASFIMAGNQGHRYDWASSFPFFYM+EEPAFS ALDAFQKAG+TVIG+DVWIGSEAM+MPGI +GHGAVIGSR+LVTKDV", "sequence_from_db": "MTNYFESPFKGKLLADQVKNPNIKVGRYSYYSGYYHGHSFDECARFLLPDRDDIDQLIVGSFCSIGTGASFIMAGNQGHRYDWASSFPFFYMKEEPAFSGALDAFQKAGDTVIGSDVWIGSEAMIMPGINVGHGAVIGSRALVTKDV", "sequence_from_broadstreet": "MTNYFESPFKGKLLADQVKNPNIKVGRYSYYSGYYHGHSFDECARFLLPDRDDIDQLIVGSFCSIGTGASFIMAGNQGHRYDWASSFPFFYMKEEPAFSGALDAFQKAGDTVIGSDVWIGSEAMIMPGINVGHGAVIGSRALVTKDVEPYTIVGGNPAKPIKKRFSDEEIAMLLKMNWWDWPTEKIEEAMPLLCSSNIVGLHRYWQGFAV", "dna_sequence_from_broadstreet": "ATGACCAACTATTTTGAAAGTCCATTTAAAGGCAAACTGCTGGCCGACCAGGTAAAGAACCCGAACATCAAAGTCGGACGGTATAGCTATTATTCCGGCTATTACCATGGCCATTCGTTTGACGAGTGCGCTCGCTTTCTCTTGCCAGATCGCGATGACATCGACCAACTGATCGTTGGTAGCTTCTGTTCCATCGGCACGGGCGCCTCCTTCATCATGGCCGGAAATCAGGGGCACCGTTATGACTGGGCGTCTTCTTTTCCCTTCTTCTACATGAAAGAGGAGCCAGCATTCTCGGGCGCACTTGATGCATTCCAAAAAGCCGGTGACACAGTCATCGGAAGTGATGTCTGGATAGGCTCTGAGGCCATGATCATGCCCGGCATCAACGTCGGTCATGGCGCTGTGATTGGAAGCCGCGCTTTGGTCACGAAAGATGTGGAGCCGTACACTATCGTTGGCGGAAATCCCGCCAAACCGATCAAGAAACGCTTCTCCGACGAGGAGATCGCCATGCTTTTGAAAATGAATTGGTGGGATTGGCCAACTGAAAAAATTGAGGAAGCAATGCCTTTGCTATGCTCATCCAACATCGTTGGGCTGCATCGATACTGGCAAGGCTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 87.76}, "gnl|BL_ORD_ID|1374|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Pseudomonas aeruginos catB6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1316", "ARO_accession": "3002678", "ARO_name": "Pseudomonas aeruginosa catB6", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.49039e-87, "max_identities": 132, "bit_score": 252.292, "cvterm_id": "36752", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYFDSPFKGKLLSEQV N NIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVDKLIIGSFCSIGSGASFIMAGNQGHR+DW +SFPFFYMQEEPAFSS+ DAFQKAG+T++GNDVWIGSEAM+MPGIKIG GAVIGSRSLVT+DV", "sequence_from_db": "MENYFDSPFKGKLLSEQVTNRNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWVTSFPFFYMQEEPAFSSSTDAFQKAGDTIVGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTRDV", "sequence_from_broadstreet": "MENYFDSPFKGKLLSEQVTNRNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWVTSFPFFYMQEEPAFSSSTDAFQKAGDTIVGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTRDVEPYTIIGGNPAKQIKKRFSDEEISLLMEMEWWNWPLDKIKTAMPLLCSSDIFGLHRHWRGIAV", "dna_sequence_from_broadstreet": "ATGGAAAATTACTTTGACAGTCCCTTCAAAGGGAAACTACTTTCAGAGCAAGTGACTAACCGCAACATCAAAGTTGGTCGGTACAGCTACTACTCTGGTTACTATCACGGGCATTCATTTGATGACTGCGCACGATACTTGCTCCCAGACCGTGATGACGTTGACAAACTAATCATCGGCAGCTTTTGCTCCATCGGAAGCGGGGCTTCTTTCATCATGGCGGGCAATCAGGGTCACCGGCATGACTGGGTAACATCTTTCCCTTTCTTCTACATGCAAGAAGAGCCAGCTTTTTCAAGTTCAACGGACGCCTTTCAAAAGGCCGGTGACACCATCGTCGGCAATGATGTCTGGATAGGATCAGAGGCAATGATTATGCCCGGCATCAAGATTGGAGATGGCGCGGTAATAGGCAGCCGATCGTTGGTGACGAGAGATGTAGAACCCTATACCATCATTGGCGGAAACCCTGCAAAGCAAATTAAAAAGCGATTCTCTGACGAGGAGATTTCATTACTCATGGAAATGGAGTGGTGGAACTGGCCGTTAGATAAAATCAAAACAGCTATGCCCCTTCTCTGCTCTTCAGACATTTTTGGTCTGCACAGGCATTGGCGTGGGATTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 89.8}, "gnl|BL_ORD_ID|2265|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "3360", "ARO_accession": "3004660", "ARO_name": "catB11", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.51536e-86, "max_identities": 128, "bit_score": 250.366, "cvterm_id": "42700", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYF+SPFKGK L EQVKNPNIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVDKLIIGSFCSIG+GASFIMAGNQGHRYDW +SFPFFYM EEPAFS ++DAFQ AGNTVIG+DVWIGSEAM+MPG+K+GHGAVIGSR+LVTKD+", "sequence_from_db": "MKNYFESPFKGKPLVEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGTGASFIMAGNQGHRYDWVTSFPFFYMNEEPAFSESVDAFQAAGNTVIGSDVWIGSEAMIMPGVKVGHGAVIGSRALVTKDI", "sequence_from_broadstreet": "MKNYFESPFKGKPLVEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGTGASFIMAGNQGHRYDWVTSFPFFYMNEEPAFSESVDAFQAAGNTVIGSDVWIGSEAMIMPGVKVGHGAVIGSRALVTKDIEPYTIVGGNPAKEIKKRFSEQEISMLLDMKWWDWPLEQIKEAMPLLCSSDIAGLYHFWQRSSA", "dna_sequence_from_broadstreet": "ATGAAGAACTATTTTGAGAGCCCGTTTAAGGGAAAACCTCTCGTCGAACAGGTAAAGAACCCAAATATCAAGGTGGGCCGTTATAGCTATTATTCAGGCTATTACCACGGGCATTCATTTGATGATTGCGCTCGCTACCTCCTGCCTGATCGTGATGACGTTGATAAATTGATAATTGGAAGCTTTTGCTCCATAGGGACGGGTGCATCTTTTATCATGGCTGGAAATCAAGGTCACCGATATGATTGGGTTACATCATTCCCTTTTTTCTATATGAATGAGGAACCGGCATTTTCGGAATCAGTTGATGCTTTCCAGGCGGCAGGTAATACCGTCATAGGAAGCGACGTGTGGATTGGCTCTGAAGCAATGATTATGCCTGGAGTAAAGGTTGGCCATGGAGCGGTAATTGGCAGCCGGGCTTTGGTTACCAAAGATATAGAGCCATACACAATTGTTGGTGGCAACCCTGCAAAAGAGATAAAGAAGCGCTTTTCAGAACAGGAAATTTCAATGTTGCTAGATATGAAGTGGTGGGATTGGCCGTTGGAGCAAATTAAAGAAGCAATGCCTCTTTTGTGCTCGTCTGATATTGCAGGCTTGTACCATTTTTGGCAGCGTTCAAGTGCCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 87.07}, "gnl|BL_ORD_ID|93|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "106", "ARO_accession": "3002681", "ARO_name": "catB9", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.82473e-78, "max_identities": 104, "bit_score": 228.024, "cvterm_id": "36789", "query": "NYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVG", "match": "N+F SPF G  L +QV NPNI VG++SYYSGYYHGHSFDDC RYL P+RDDVDKL+IGSFCSIGSGA F+MAGNQGHR DW S+FPFFY Q+   F+ A D F ++G+T+IG+DVWIG+EAM+MPG+KIGHGA+I SRS+VTKDV ", "sequence_from_db": "NFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFY-QDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVA", "sequence_from_broadstreet": "MNFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFYQDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVAPYEVVGSNPAKHIKFRFSDVEIAMLLEMAWWNWPESWLKESMQSLCSSDIEGLYLNWQSKART", "dna_sequence_from_broadstreet": "ATGAACTTCTTTACGTCTCCATTTTCTGGGATTCCCTTAGATCAGCAAGTAACAAATCCGAACATTATTGTGGGAAAACACAGTTATTATTCTGGTTATTATCACGGGCACAGTTTCGATGATTGTGTGCGATATTTACATCCAGAAAGAGATGACGTTGATAAGTTAGTCATAGGGAGTTTTTGTTCTATAGGCTCTGGTGCTGTATTTATGATGGCCGGTAATCAAGGGCATCGCAGTGATTGGATAAGTACATTCCCATTTTTCTATCAGGATAATGATAATTTTGCAGATGCACGCGATGGTTTTACGCGTTCAGGAGACACAATTATTGGTCATGATGTGTGGATTGGCACTGAGGCTATGATAATGCCTGGGGTTAAAATTGGACATGGAGCGATAATCGCCAGTCGTTCAGTAGTGACTAAGGATGTTGCACCTTATGAAGTGGTCGGTTCAAATCCTGCTAAACATATCAAGTTTAGATTTTCTGATGTGGAAATAGCGATGTTACTTGAAATGGCATGGTGGAATTGGCCAGAATCGTGGTTGAAAGAGAGTATGCAGTCTCTGTGTTCATCAGACATTGAAGGGCTTTATCTCAATTGGCAGTCAAAAGCACGCACATAA", "partial": "0", "query_start": 1170, "query_end": 1607, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 71.23}, "gnl|BL_ORD_ID|2580|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Pseudomonas aeruginosa catB7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1042", "ARO_accession": "3002679", "ARO_name": "Pseudomonas aeruginosa catB7", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.78045e-77, "max_identities": 117, "bit_score": 226.868, "cvterm_id": "36804", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "M NYF+SPF+GKLLSEQV NPNI+VGRYSYYSGYYHGHSFDDCARYL PDRDDVDKL+IGSFCSIGSGA+FIMAGNQGHR +WAS+FPF +M EEP F+ A++ +Q AG+T+IG+DVWIG+EAM MPG+++GHGA+IGSR+LVT DV     V    A  + +R", "sequence_from_db": "MGNYFESPFRGKLLSEQVSNPNIRVGRYSYYSGYYHGHSFDDCARYLMPDRDDVDKLVIGSFCSIGSGAAFIMAGNQGHRAEWASTFPFHFMHEEPVFAGAVNGYQPAGDTLIGHDVWIGTEAMFMPGVRVGHGAIIGSRALVTGDVEPYAIVGGNPARTIRKR", "sequence_from_broadstreet": "MGNYFESPFRGKLLSEQVSNPNIRVGRYSYYSGYYHGHSFDDCARYLMPDRDDVDKLVIGSFCSIGSGAAFIMAGNQGHRAEWASTFPFHFMHEEPVFAGAVNGYQPAGDTLIGHDVWIGTEAMFMPGVRVGHGAIIGSRALVTGDVEPYAIVGGNPARTIRKRFSDGDIQNLLEMAWWDWPLADIEAAMPLLCTGDIPALYRHWKQRQATA", "dna_sequence_from_broadstreet": "ATGGGCAACTATTTCGAGAGCCCCTTCAGGGGCAAGCTGCTCTCGGAACAGGTCAGCAACCCGAACATACGGGTGGGGCGCTACAGCTACTACTCCGGCTACTATCACGGGCATTCCTTCGACGACTGCGCCCGCTACCTGATGCCGGACCGCGACGACGTGGACAAGCTGGTCATCGGCAGTTTCTGCTCGATCGGCAGTGGCGCCGCCTTCATCATGGCCGGCAACCAGGGACACCGCGCCGAATGGGCGTCGACCTTCCCCTTCCACTTCATGCACGAAGAGCCTGTCTTCGCCGGCGCCGTGAACGGCTATCAGCCAGCCGGCGACACGCTGATCGGCCATGACGTCTGGATCGGTACCGAGGCGATGTTCATGCCCGGCGTACGGGTCGGCCACGGAGCCATCATCGGCAGCCGCGCGCTGGTGACCGGCGATGTCGAGCCCTATGCCATCGTCGGCGGTAACCCGGCCCGGACCATTCGTAAGCGCTTTTCCGATGGCGATATCCAGAACCTGCTGGAAATGGCCTGGTGGGACTGGCCACTGGCCGATATCGAGGCAGCCATGCCACTGCTGTGTACTGGGGATATCCCCGCCTTGTACCGGCACTGGAAACAGCGCCAGGCCACGGCCTGA", "partial": "0", "query_start": 1164, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 71.34}, "gnl|BL_ORD_ID|2572|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Agrobacterium fabrum chloramphenicol acetyltransferase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2890", "ARO_accession": "3004451", "ARO_name": "Agrobacterium fabrum chloramphenicol acetyltransferase", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.31903e-65, "max_identities": 106, "bit_score": 197.208, "cvterm_id": "36775", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "M NYF+SPF+G  L +QVK+PN+ VG+YSYYSGYYHGHSF+DCARYL PD +  D+L+IGSFCSIGSGA+FIMAGNQGHR +W S+FPFF+M E P F +A + +  AG+TVIGNDVWIGSEA++MPGI +G GAVIG+R+LVTKDV     V    A  + +R", "sequence_from_db": "MENYFESPFRGITLDKQVKSPNLVVGKYSYYSGYYHGHSFEDCARYLLPD-EGADRLVIGSFCSIGSGAAFIMAGNQGHRNEWISTFPFFFMPEVPEFENAANGYLPAGDTVIGNDVWIGSEAIIMPGITVGDGAVIGTRALVTKDVEPYAIVGGNPAKTIRKR", "sequence_from_broadstreet": "MENYFESPFRGITLDKQVKSPNLVVGKYSYYSGYYHGHSFEDCARYLLPDEGADRLVIGSFCSIGSGAAFIMAGNQGHRNEWISTFPFFFMPEVPEFENAANGYLPAGDTVIGNDVWIGSEAIIMPGITVGDGAVIGTRALVTKDVEPYAIVGGNPAKTIRKRFDDDSIALLLEMKWWGWPAERLKAAMPLMTSGNVAALYRFWRSDSL", "dna_sequence_from_broadstreet": "ATGGAAAACTATTTCGAAAGCCCATTCCGGGGCATTACACTCGACAAGCAGGTGAAGAGCCCGAACCTGGTGGTCGGAAAATACAGCTATTATTCCGGCTATTACCACGGCCACAGTTTCGAGGATTGCGCCCGGTACCTGCTGCCCGATGAGGGCGCGGACAGGCTGGTGATCGGAAGCTTCTGCTCGATCGGTTCGGGCGCCGCCTTCATCATGGCGGGCAATCAGGGGCACCGCAACGAATGGATCAGTACCTTCCCGTTCTTCTTCATGCCGGAGGTGCCGGAATTCGAGAATGCCGCCAACGGTTATCTGCCGGCGGGCGACACCGTCATCGGCAACGATGTCTGGATCGGTTCGGAAGCGATCATCATGCCCGGCATCACCGTCGGTGATGGCGCGGTGATCGGAACGCGGGCGCTGGTGACGAAGGACGTCGAGCCCTACGCCATCGTCGGCGGCAACCCCGCAAAAACGATCCGCAAGCGGTTTGACGACGATAGCATCGCCCTGCTGCTCGAGATGAAATGGTGGGGCTGGCCGGCGGAGCGGCTGAAAGCTGCAATGCCGCTGATGACCAGCGGCAATGTCGCGGCGCTCTATCGTTTCTGGCGGTCCGATAGCCTCTAG", "partial": "0", "query_start": 1164, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 64.63}, "gnl|BL_ORD_ID|789|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "837", "ARO_accession": "3002845", "ARO_name": "vatH", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28247e-30, "max_identities": 62, "bit_score": 107.457, "cvterm_id": "36779", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "+ +   +  PNI VG ++YY    +G  F+D   Y +    D  +LIIG FCSIG G +FIM G   HR D  S++PF  +       +  LD     G+T++GNDVWIG +A +MPG+KIG GA+I ++S+VTKDV     V    A  + +R", "sequence_from_db": "QFVKPSLTRPNIIVGEFTYYDSK-NGELFEDQVLYHYEIIGD--RLIIGKFCSIGPGVTFIMNG-ANHRMD-GSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKR", "sequence_from_broadstreet": "MAEKLKGPNSNEMYPIAGNKSVQFVKPSLTRPNIIVGEFTYYDSKNGELFEDQVLYHYEIIGDRLIIGKFCSIGPGVTFIMNGANHRMDGSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKRFSESKIQELLKIKWWDFEDQVISDNIDAILSLDVEALNNISKEND", "dna_sequence_from_broadstreet": "ATGGCAGAAAAATTAAAAGGACCCAACTCAAATGAAATGTATCCGATTGCCGGAAATAAAAGTGTTCAATTTGTTAAACCGTCATTAACAAGGCCCAATATTATAGTTGGTGAGTTCACTTATTATGATAGCAAGAACGGAGAGCTTTTTGAGGATCAAGTTCTGTATCATTATGAAATTATAGGGGATCGACTGATCATCGGGAAATTTTGTTCAATCGGTCCTGGAGTCACTTTTATTATGAATGGAGCTAATCATCGCATGGATGGCTCCACTTATCCATTTAATATCTTTGGGCATGGGTGGGAAAAGCATACACCTACACTAGATATGCTGCCTTTAAAGGGGGATACTATTGTTGGTAATGACGTATGGATTGGACTAGATGCTACAATTATGCCAGGCGTAAAAATAGGAGACGGCGCGATTATTGCAGCCAAATCTGTAGTAACAAAAGACGTTGACCCCTCCACAATTGTTGGTGGTAATCCTGCAAAACAAATAAAGAAACGATTTTCGGAGTCAAAAATTCAAGAACTATTAAAGATAAAATGGTGGGATTTTGAAGACCAGGTTATTAGCGATAATATTGATGCTATTCTAAGTTTGGATGTTGAAGCGCTTAATAATATTTCTAAAGAAAATGATTAG", "partial": "0", "query_start": 1197, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 40.26}, "gnl|BL_ORD_ID|820|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "872", "ARO_accession": "3002842", "ARO_name": "vatC", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.04845e-30, "max_identities": 61, "bit_score": 106.686, "cvterm_id": "36766", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "+ +   +  PNI VG YSYY     G SF+    Y +    D  KLI+G FCSIG G +FIM G   HR D  S+FPF  +       +  L+     GNT IGNDVWIG +  +MPG+KIG+GA+I ++S+VTK+V", "sequence_from_db": "QFIKPSITKPNILVGEYSYYDSK-DGESFESQVLYHYELIGD--KLILGKFCSIGPGTTFIMNG-ANHRMD-GSTFPFNLFGNGWEKHTPTLEDLPYKGNTEIGNDVWIGRDVTIMPGVKIGNGAIIAAKSVVTKNV", "sequence_from_broadstreet": "MKWQNQQGPNPEEIYPIEGNKHVQFIKPSITKPNILVGEYSYYDSKDGESFESQVLYHYELIGDKLILGKFCSIGPGTTFIMNGANHRMDGSTFPFNLFGNGWEKHTPTLEDLPYKGNTEIGNDVWIGRDVTIMPGVKIGNGAIIAAKSVVTKNVDPYSVVGGNPSRLIKIRFSKEKIAALLKVRWWDLEIETINENIDCILNGDIKKVKRS", "dna_sequence_from_broadstreet": "ATGAAATGGCAAAATCAGCAAGGCCCCAATCCAGAAGAAATATACCCTATAGAAGGTAATAAACATGTTCAATTTATTAAACCATCTATAACAAAGCCCAATATTTTAGTTGGGGAATATTCATATTACGATAGTAAAGATGGTGAATCTTTTGAAAGCCAAGTTCTTTATCACTATGAATTGATTGGGGATAAACTAATATTAGGGAAGTTTTGTTCTATTGGACCCGGAACGACATTTATAATGAATGGGGCTAATCATCGTATGGATGGTTCAACATTTCCATTCAATCTTTTCGGAAATGGTTGGGAGAAGCATACCCCTACATTGGAAGACCTTCCTTATAAGGGTAACACGGAAATTGGGAACGATGTTTGGATTGGACGAGATGTGACAATTATGCCCGGTGTAAAAATAGGAAACGGGGCTATTATTGCAGCAAAATCGGTTGTGACAAAGAACGTTGATCCTTATTCAGTTGTTGGCGGTAATCCTTCACGATTAATTAAGATAAGGTTTTCCAAGGAAAAAATCGCAGCATTACTAAAAGTAAGGTGGTGGGACCTAGAGATAGAGACGATAAATGAAAATATTGATTGCATCCTGAATGGTGATATAAAAAAGGTTAAAAGAAGTTAG", "partial": "0", "query_start": 1197, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 44.53}, "gnl|BL_ORD_ID|1120|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatB", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1189", "ARO_accession": "3002841", "ARO_name": "vatB", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.49332e-30, "max_identities": 58, "bit_score": 106.301, "cvterm_id": "35508", "query": "LLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQE--EPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": " +   + NPNI VG Y+YYS       F++   + +  R D  KL+IG FC+I  G  FIM G   HR +  +++PF  M    E A + +L+     G+TV+GNDVWIG    VMPGI+IG GA++ + S+VTKDV", "sequence_from_db": "FIKNTITNPNIIVGDYTYYSDVNGAEKFEEHVTHHYEFRGD--KLVIGKFCAIAEGIEFIMNG-ANHRMNSITTYPFNIMGNGWEKA-TPSLEDLPFKGDTVVGNDVWIGQNVTVMPGIQIGDGAIVAANSVVTKDV", "sequence_from_broadstreet": "MKYGPDPNSIYPHEEIKSVCFIKNTITNPNIIVGDYTYYSDVNGAEKFEEHVTHHYEFRGDKLVIGKFCAIAEGIEFIMNGANHRMNSITTYPFNIMGNGWEKATPSLEDLPFKGDTVVGNDVWIGQNVTVMPGIQIGDGAIVAANSVVTKDVPPYRIIGGNPSRIIKKRFEDELIDYLLQIKWWDWSAQKIFSNLETLCSSDLEKIKSIRD", "dna_sequence_from_broadstreet": "ATGAAATATGGCCCTGATCCAAATAGCATATATCCACATGAAGAAATAAAAAGTGTTTGTTTTATTAAAAATACAATTACCAATCCAAATATTATAGTTGGAGATTATACTTACTATTCCGATGTTAACGGAGCTGAAAAATTTGAAGAACATGTGACACATCATTATGAATTTAGGGGTGATAAACTTGTAATTGGCAAGTTTTGTGCAATAGCTGAAGGTATAGAATTTATTATGAATGGAGCAAACCATAGAATGAATTCAATAACAACTTATCCTTTTAATATAATGGGAAATGGTTGGGAAAAAGCAACTCCATCTCTTGAAGATTTACCATTTAAGGGAGATACTGTTGTTGGAAATGATGTGTGGATTGGTCAGAATGTTACTGTTATGCCAGGAATTCAAATAGGAGATGGAGCAATTGTTGCTGCGAATTCAGTTGTTACAAAAGATGTACCACCATATCGTATTATTGGTGGAAATCCGAGTAGAATTATAAAGAAAAGGTTTGAAGATGAATTGATAGATTATTTATTGCAAATAAAATGGTGGGATTGGTCAGCACAAAAAATATTTTCTAATCTTGAAACACTTTGTAGCTCTGATTTAGAGAAAATAAAATCTATTCGAGATTAG", "partial": "0", "query_start": 1200, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 42.34}, "gnl|BL_ORD_ID|269|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "290", "ARO_accession": "3002843", "ARO_name": "vatD", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.50114e-29, "max_identities": 59, "bit_score": 103.99, "cvterm_id": "36779", "query": "NIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "N++VG YSYY    +G +FD    Y +P  +D  KL IG FCSIG G + IM G   HR D  S++PF  +          LD     G+T+IGNDVWIG + ++MPG+KIG GA++ + S+V KD+          A  + QR", "sequence_from_db": "NVEVGEYSYYDSK-NGETFDKQILYHYPILND--KLKIGKFCSIGPGVTIIMNG-ANHRMD-GSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDVWIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQR", "sequence_from_broadstreet": "MKMYPIEGNKSVQFIKPILEKLENVEVGEYSYYDSKNGETFDKQILYHYPILNDKLKIGKFCSIGPGVTIIMNGANHRMDGSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDVWIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQRFDQDTINQLLDIKWWNWPIDIINENIDKILDNSIIREVIWKK", "dna_sequence_from_broadstreet": "ATGAAAATGTATCCTATAGAAGGAAACAAATCAGTACAATTTATCAAACCTATTTTAGAAAAATTAGAAAATGTTGAGGTTGGAGAATACTCATATTATGATTCTAAGAATGGAGAAACTTTTGATAAGCAAATTTTATATCATTATCCAATCTTAAACGATAAGTTAAAAATAGGTAAATTTTGCTCAATAGGACCAGGTGTAACTATTATTATGAATGGAGCAAATCATAGAATGGATGGCTCAACATATCCATTTAATTTATTTGGTAATGGATGGGAGAAACATATGCCAAAATTAGATCAACTACCTATTAAGGGGGATACAATAATAGGTAATGATGTATGGATAGGAAAAGATGTTGTAATTATGCCAGGAGTAAAAATCGGGGATGGTGCAATAGTAGCTGCTAATTCTGTTGTTGTAAAAGATATAGCGCCATACATGTTAGCTGGAGGAAATCCTGCTAACGAAATAAAACAAAGATTTGATCAAGATACAATAAATCAGCTGCTTGATATAAAATGGTGGAATTGGCCAATAGACATTATTAATGAGAATATAGATAAAATTCTTGATAATAGCATCATTAGAGAAGTCATATGGAAAAAATGA", "partial": "0", "query_start": 1227, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 40.97}, "gnl|BL_ORD_ID|1635|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1735", "ARO_accession": "3002840", "ARO_name": "vatA", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.74342e-29, "max_identities": 68, "bit_score": 104.375, "cvterm_id": "35508", "query": "PFKG----KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDV--DKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF--FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "P KG    + +   + N NI VG YSYY     G SF+D   Y +    +V  DKLIIG FCSIG G +FIM G   HR D  S++PF  F M  E    S  D   K G+  IGNDVWIG +  +MPG+KIG GA+I + ++VTK+V", "sequence_from_db": "PIKGNRNLQFIKPTITNENILVGEYSYYDSK-RGESFEDQVLYHY----EVIGDKLIIGRFCSIGPGTTFIMNG-ANHRMD-GSTYPFHLFRMGWEKYMPSLKDLPLK-GDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNV", "sequence_from_broadstreet": "MNLNNDHGPDPENILPIKGNRNLQFIKPTITNENILVGEYSYYDSKRGESFEDQVLYHYEVIGDKLIIGRFCSIGPGTTFIMNGANHRMDGSTYPFHLFRMGWEKYMPSLKDLPLKGDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNVAPYSIVGGNPLKFIRKRFSDGVIEEWLALQWWNLDMKIINENLPFIINGDIEMLKRKRKLLDDT", "dna_sequence_from_broadstreet": "TTGAATTTAAACAATGACCATGGACCTGATCCCGAAAATATTTTACCGATAAAAGGGAATCGGAATCTTCAATTTATAAAACCTACTATAACGAACGAAAACATTTTGGTGGGGGAATATTCTTATTATGATAGTAAGCGAGGAGAATCCTTTGAAGATCAAGTCTTATATCATTATGAAGTGATTGGAGATAAGTTGATTATAGGAAGATTTTGTTCAATTGGTCCCGGAACAACATTTATTATGAATGGTGCAAACCATCGGATGGATGGATCAACATATCCTTTTCATCTATTCAGGATGGGTTGGGAGAAGTATATGCCTTCCTTAAAAGATCTTCCCTTGAAAGGGGACATTGAAATTGGAAATGATGTATGGATAGGTAGAGATGTAACCATTATGCCTGGGGTGAAAATTGGGGACGGGGCAATCATTGCTGCAGAAGCTGTTGTCACAAAGAATGTTGCTCCCTATTCTATTGTCGGTGGAAATCCCTTAAAATTTATAAGAAAAAGGTTTTCTGATGGAGTTATCGAAGAATGGTTAGCTTTACAATGGTGGAATTTAGATATGAAAATTATTAATGAAAATCTTCCCTTCATAATAAATGGAGATATCGAAATGCTGAAGAGAAAAAGAAAACTTCTAGATGACACTTGA", "partial": "0", "query_start": 1185, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 45.95}, "gnl|BL_ORD_ID|1429|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1519", "ARO_accession": "3002844", "ARO_name": "vatE", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.62292e-28, "max_identities": 55, "bit_score": 100.523, "cvterm_id": "36779", "query": "VKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQ-EEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVG", "match": "+K+PNI++G Y+YY    +   F+    + +    D  KLIIG FCSI SG  FIM G   H     S++PF  +  +   ++  L      G+TV+GNDVW G    V+PG+KIG GA+IG+ S+VTKDV ", "sequence_from_db": "IKSPNIEIGDYTYYDDPVNPTDFEKHVTHHYEFLGD--KLIIGKFCSIASGIEFIMNG-ANHVMKGISTYPFNILGGDWQQYTPELTDLPLKGDTVVGNDVWFGQNVTVLPGVKIGDGAIIGANSVVTKDVA", "sequence_from_broadstreet": "MTIPDANAIYPNSAIKEVVFIKNVIKSPNIEIGDYTYYDDPVNPTDFEKHVTHHYEFLGDKLIIGKFCSIASGIEFIMNGANHVMKGISTYPFNILGGDWQQYTPELTDLPLKGDTVVGNDVWFGQNVTVLPGVKIGDGAIIGANSVVTKDVAPYTIVGGNPIQLIGPRFEPEVIQALENLAWWNKDIEWITANVPKLMQTTPTLELINSLMEK", "dna_sequence_from_broadstreet": "ATGACTATACCTGACGCAAATGCAATCTATCCTAACTCAGCCATCAAAGAGGTTGTCTTTATCAAGAACGTGATCAAAAGTCCCAATATTGAAATTGGGGACTACACCTATTATGATGACCCAGTAAATCCCACCGATTTTGAGAAACACGTTACCCATCACTATGAATTTCTAGGCGACAAATTAATCATCGGTAAATTTTGTTCTATCGCCAGTGGCATTGAATTTATCATGAACGGTGCCAACCACGTAATGAAAGGTATTTCGACTTATCCATTTAATATTTTAGGTGGCGATTGGCAACAATACACTCCTGAACTGACTGATTTGCCGTTGAAAGGTGATACTGTAGTCGGAAATGACGTGTGGTTTGGGCAAAATGTGACCGTCCTACCAGGCGTAAAAATAGGTGACGGTGCCATTATCGGAGCAAATAGTGTTGTAACAAAAGACGTCGCTCCATATACAATTGTCGGTGGCAATCCAATTCAACTCATCGGACCAAGATTTGAACCGGAAGTTATTCAAGCATTAGAAAATCTGGCATGGTGGAATAAAGATATTGAATGGATAACTGCTAATGTTCCTAAACTAATGCAAACAACACCCACACTTGAATTGATAAACAGTTTAATGGAAAAATAA", "partial": "0", "query_start": 1215, "query_end": 1607, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 41.67}, "gnl|BL_ORD_ID|2102|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatF", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2260", "ARO_accession": "3003744", "ARO_name": "vatF", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.21527e-27, "max_identities": 56, "bit_score": 100.523, "cvterm_id": "40164", "query": "LLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": " +    +NPNI +G Y+YY       +F+    Y +P   D  KLIIG FC++  G  FIM G   H+    S++PF  +       + + D     G+T +GNDVWIG + ++MPG+ IG+GA+I SRS+VT+DV     V    A  +  R", "sequence_from_db": "FIKNTTQNPNIIIGDYTYYDDPQDSENFERNVLYHYPFIGD--KLIIGKFCALAHGVKFIMNG-ANHKMSGLSTYPFNIFGNGWERVAPSRDELPYKGDTHVGNDVWIGYDVLIMPGVTIGNGAIISSRSVVTRDVPAYSVVGGNPATLIKNR", "sequence_from_broadstreet": "MEDKPILGPDPQCKHPMVGFSQVCFIKNTTQNPNIIIGDYTYYDDPQDSENFERNVLYHYPFIGDKLIIGKFCALAHGVKFIMNGANHKMSGLSTYPFNIFGNGWERVAPSRDELPYKGDTHVGNDVWIGYDVLIMPGVTIGNGAIISSRSVVTRDVPAYSVVGGNPATLIKNRFSAEVIGKLQTIAWWDWPIDAISRNLHLIVAGDIEALARAASEIDHT", "dna_sequence_from_broadstreet": "ATGGAAGATAAGCCAATATTAGGGCCAGATCCCCAGTGTAAACACCCGATGGTGGGGTTTTCTCAAGTATGCTTTATCAAAAATACCACACAGAATCCGAACATTATTATCGGTGATTATACCTACTACGACGATCCACAAGATTCTGAAAACTTTGAACGTAACGTGCTTTATCACTACCCCTTTATTGGTGATAAGCTGATTATCGGCAAATTCTGTGCATTAGCTCATGGGGTGAAGTTCATTATGAATGGTGCCAACCATAAAATGTCTGGGTTATCGACTTACCCATTCAATATTTTTGGTAACGGTTGGGAAAGAGTCGCCCCGTCCAGGGATGAGCTGCCTTATAAAGGCGATACTCATGTCGGAAATGATGTGTGGATTGGCTATGATGTGTTGATTATGCCAGGTGTCACCATTGGCAATGGGGCAATTATTTCATCACGCTCAGTGGTCACGCGCGATGTGCCCGCTTATAGTGTGGTCGGCGGTAATCCCGCAACACTGATTAAAAATCGCTTCTCAGCCGAGGTTATCGGTAAGCTACAAACCATTGCCTGGTGGGATTGGCCAATAGACGCGATCAGTCGCAATCTACACCTGATCGTTGCCGGTGATATCGAGGCATTAGCGCGAGCAGCCAGCGAGATTGATCACACCTAA", "partial": "0", "query_start": 1200, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 36.6}, "gnl|BL_ORD_ID|2299|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "VatI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2523", "ARO_accession": "3003987", "ARO_name": "VatI", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24117e-27, "max_identities": 57, "bit_score": 97.8265, "cvterm_id": "40862", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "+ +   +  PNI  G YSYY    +G SF+D   Y +       KL+IG FCSI S   F+M G   HR D  S+FPF  +      F+ +LD     G+T+IGNDVWIG  A +M G++IG GA+I + ++V KDV", "sequence_from_db": "QFIKNTITKPNIIAGDYSYYYAL-NGESFEDQVLYHYEFIGT--KLMIGKFCSIASEVRFMMDGGN-HRMD-GSTFPFNIFGNGWEKFTPSLDQLPIKGDTIIGNDVWIGRRATIMSGVRIGDGAIIAAEAVVVKDV", "sequence_from_broadstreet": "MTGPNPNERYPIPGDNNLQFIKNTITKPNIIAGDYSYYYALNGESFEDQVLYHYEFIGTKLMIGKFCSIASEVRFMMDGGNHRMDGSTFPFNIFGNGWEKFTPSLDQLPIKGDTIIGNDVWIGRRATIMSGVRIGDGAIIAAEAVVVKDVEPYTIVGGNPAKDIRKRYSTEVIQELLDIKWWDCDIEVINQYIGAIVSGDMDLLRKMRQN", "dna_sequence_from_broadstreet": "ATGACAGGACCGAATCCAAATGAGAGATATCCTATACCCGGAGATAACAATCTTCAGTTTATCAAGAACACGATTACAAAACCTAATATTATCGCAGGGGATTATTCATACTACTATGCCTTAAACGGAGAATCATTTGAGGATCAAGTATTGTATCATTATGAATTCATTGGAACTAAATTAATGATCGGCAAGTTTTGTTCCATTGCTTCCGAGGTCAGATTTATGATGGATGGAGGGAACCATCGGATGGACGGTTCAACCTTTCCATTTAATATCTTTGGAAACGGCTGGGAGAAATTCACTCCATCTTTGGATCAATTGCCGATCAAGGGAGATACGATCATTGGAAATGACGTGTGGATCGGAAGGCGTGCAACGATCATGTCGGGTGTAAGGATTGGCGATGGAGCTATCATTGCCGCTGAAGCTGTCGTTGTAAAGGATGTGGAGCCTTATACGATCGTTGGAGGCAATCCAGCGAAGGATATCCGCAAGCGATATTCCACCGAAGTCATTCAAGAGTTATTGGATATTAAATGGTGGGATTGCGATATCGAAGTCATCAATCAATATATTGGCGCAATTGTAAGCGGAGATATGGACTTGCTTAGAAAAATGAGACAAAATTAG", "partial": "0", "query_start": 1197, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 41.61}, "gnl|BL_ORD_ID|2226|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "apmA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2395", "ARO_accession": "3003918", "ARO_name": "apmA", "ARO_category": {"41422": {"category_aro_accession": "3004258", "category_aro_cvterm_id": "41422", "category_aro_name": "amp acetyltransferase", "category_aro_description": "A family of acetyltransferases that confer resistance to apramycin.", "category_aro_class_name": "AMR Gene Family"}, "35955": {"category_aro_accession": "0000037", "category_aro_cvterm_id": "35955", "category_aro_name": "apramycin", "category_aro_description": "Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.00481428, "max_identities": 33, "bit_score": 33.113, "cvterm_id": "35508", "query": "IGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPA-FSSALD-------AFQKAGNTVIGNDVWIGSEAMVMPGI--KIGHGAVIGSRSLVTKDV", "match": "IG F SI +G + I A +Q +    +     F+ +E  A F   L        A+ K   T IG+DV+IG+ A +       IG GA+IGS ++V ++V", "sequence_from_db": "IGQFTSI-NGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMT-IGSDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENV", "sequence_from_broadstreet": "MKTRLEQVLERYLNGREVAVWGVPTRRLLRALKPFKFHTADRVDPQYHYVVAVTDDDLTDFLSDEQSKSFQYANDYLTFDDEGGELPFERMCFNVPVGRQTYFGDGVVGACENGYIKSIGQFTSINGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMTIGSDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENVPPFAVVVGVPARIKRYRFSKEMIETLLRVKWWDWSIEEINENVDALISPELFMKKYGSL", "dna_sequence_from_broadstreet": "ATGAAAACCAGACTTGAACAAGTTTTAGAACGTTATCTCAACGGACGCGAGGTAGCTGTATGGGGTGTTCCGACACGCCGTTTGCTTCGTGCATTAAAACCTTTTAAATTTCATACTGCCGATCGTGTTGATCCTCAATATCATTATGTTGTTGCTGTAACCGATGACGACTTAACCGACTTTTTATCCGATGAACAGAGCAAGTCGTTTCAATACGCGAATGACTACCTTACGTTTGACGACGAGGGAGGCGAACTTCCGTTTGAACGAATGTGCTTCAATGTCCCCGTTGGCAGGCAAACGTATTTTGGAGACGGTGTCGTAGGAGCTTGCGAAAACGGGTATATCAAGAGCATCGGCCAATTTACATCGATTAACGGCACGGCAGAGATCCATGCGAACCATCAGTTAAACATGACCTTTGTAAGCGACGATATTCAAAACTTCTTCAACGAAGAAAGCATGGCTGTATTCCAAGAAAAGCTGCGAAAAGACCCGAAACACCCTTATGCTTATAGCAAAGAACCTATGACCATAGGTAGCGATGTTTATATCGGCGCACATGCATTCATCAATGCTTCCACTGTGACAAGCATCGGTGACGGTGCAATAATTGGCTCAGGGGCAGTAGTTCTGGAAAATGTTCCTCCTTTTGCTGTCGTCGTTGGTGTCCCTGCGAGAATCAAGCGTTACCGCTTCTCAAAGGAGATGATTGAAACCCTCCTTCGTGTCAAATGGTGGGACTGGAGTATAGAGGAAATTAACGAAAATGTTGATGCGCTTATATCACCTGAACTATTTATGAAAAAGTACGGGAGTTTGTAA", "partial": "0", "query_start": 1338, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 33.33}}, "NODE_54_length_1272_cov_25.1921_2 # 1130 # 1270 # 1 # ID=54_2;partial=01;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.496": {"gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1678", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.5007e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "35914", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "993", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.69358e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1370", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.71194e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1960|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "475", "model_id": "2117", "ARO_accession": "3002578", "ARO_name": "AAC(6')-Ib7", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.30278e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "35906", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MRSRNWSRTLTERSGGNGAVAVFMACYDCFFVQSMPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGCGCTCACGCAACTGGTCCAGAACCTTGACCGAACGCAGCGGTGGTAACGGCGCAGTGGCGGTTTTCATGGCTTGTTATGACTGTTTTTTTGTACAGTCTATGCCTCGGGCATCCAAGCAGCAAGCGCGTTACGCCGTGGGTCGATGTTTGATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2071", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95946e-26, "max_identities": 41, "bit_score": 90.1225, "cvterm_id": "36884", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 93.18}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1801", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.37107e-26, "max_identities": 43, "bit_score": 89.3521, "cvterm_id": "35732", "query": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MKNTIH    NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MKNTIH---INSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1130, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 91.49}, "gnl|BL_ORD_ID|865|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "922", "ARO_accession": "3002599", "ARO_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.02077e-25, "max_identities": 42, "bit_score": 90.5077, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2046|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "339", "ARO_accession": "3002598", "ARO_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "41439": {"category_aro_accession": "3004275", "category_aro_cvterm_id": "41439", "category_aro_name": "ANT(3'')", "category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.35403e-25, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36783", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1235", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.93886e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|194|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(3)-Ib/AAC(6')-Ib''", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "209", "ARO_accession": "3002600", "ARO_name": "AAC(3)-Ib/AAC(6')-Ib''", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.12027e-24, "max_identities": 37, "bit_score": 87.0409, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEW+NRSHIVEWWGGEEA", "sequence_from_db": "LTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSIIATVKIGPDEISAMRAVLDLFGKEFEDIPTYSDRQPTNEYLANLLHSETFIALAAFDRGTAIGGLAAYVLPKFEQARSEIYIYDLAVASSHRRLGVATALISHLKRVAVELGAYVIYVQADYGDDPAVALYTKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGGGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCATCATTGCAACCGTCAAGATCGGCCCTGACGAAATTTCAGCCATGAGGGCTGTGCTCGATCTCTTCGGCAAAGAGTTTGAGGACATTCCAACCTACTCTGATCGCCAGCCGACCAATGAGTATCTTGCCAATCTTCTGCACAGCGAGACGTTCATCGCGCTCGCTGCTTTTGACCGCGGAACAGCAATAGGTGGGCTCGCAGCCTACGTTCTACCCAAGTTCGAGCAAGCGCGAAGCGAGATCTACATTTATGACTTGGCAGTCGCTTCCAGCCATCGAAGGCTAGGAGTCGCAACTGCCCTGATTAGCCACCTGAAGCGTGTGGCGGTTGAACTTGGCGCGTATGTAATCTATGTGCAAGCAGACTACGGTGACGATCCGGCAGTCGCTCTCTACACAAAGCTTGGAGTTCGGGAAGACGTCATGCACTTCGACATTGATCCATTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGGTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAGGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 94.87}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "63", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.13431e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1002", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.40495e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1068", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.7601e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "444", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.51337e-16, "max_identities": 27, "bit_score": 64.3142, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 1190, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1000", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.06367e-15, "max_identities": 26, "bit_score": 62.7734, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1190, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.3, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1577", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.64612e-15, "max_identities": 27, "bit_score": 61.2326, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 71.05}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1657", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.73463e-15, "max_identities": 25, "bit_score": 60.8474, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDE", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 65.79}, "gnl|BL_ORD_ID|125|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIb", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "140", "ARO_accession": "3002595", "ARO_name": "AAC(6')-IIb", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.683e-14, "max_identities": 24, "bit_score": 58.9214, "cvterm_id": "36937", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGE", "match": "VTLR MTE D+ ML+EWLNR HIVEWWGGE", "sequence_from_db": "VTLRPMTEDDIGMLHEWLNRPHIVEWWGGE", "sequence_from_broadstreet": "MHPGVVTLRPMTEDDIGMLHEWLNRPHIVEWWGGERPSLEEVKEDYRPSALAEEGVTPYIGLLDGTPFAFAQSYVALGSGGGWWEEETDPGVRGIDQSIADSGLLGRGYGTRLVQALVDLLFADPQVSKVQTDPSPNNMRAIRCYEKAGFRKVKVVSTPDGPAMYMLHERPLVNGLRSAA", "dna_sequence_from_broadstreet": "ATGCATCCCGGCGTTGTTACTCTGCGTCCGATGACCGAAGACGACATCGGTATGCTTCACGAATGGTTGAATCGGCCGCACATTGTCGAATGGTGGGGTGGTGAGCGGCCCTCGCTCGAAGAGGTGAAAGAGGACTATCGGCCCAGCGCGTTGGCCGAAGAAGGAGTGACGCCGTACATCGGTTTGCTTGACGGAACTCCATTCGCGTTCGCACAGTCGTACGTTGCGCTCGGGTCGGGTGGTGGATGGTGGGAGGAAGAGACCGATCCTGGTGTCCGCGGAATCGATCAATCAATCGCCGATTCCGGGCTTCTCGGAAGAGGTTACGGCACTCGGCTGGTGCAGGCGCTTGTTGATTTGCTGTTCGCCGACCCGCAGGTATCCAAGGTTCAGACGGACCCCTCCCCGAACAACATGCGCGCGATACGCTGCTATGAGAAGGCAGGCTTCCGGAAGGTCAAGGTCGTTTCAACACCGGATGGGCCGGCCATGTACATGTTGCACGAGCGTCCGTTGGTGAACGGTTTGCGCAGTGCGGCCTAA", "partial": "0", "query_start": 1175, "query_end": 1264, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 80.0}, "gnl|BL_ORD_ID|1024|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "325", "model_id": "1093", "ARO_accession": "3002585", "ARO_name": "AAC(6')-31", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.8099e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36803", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "MTEHDL ML++WLNR HIVEWWGGEE", "sequence_from_db": "MTEHDLPMLHDWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MTEHDLPMLHDWLNRPHIVEWWGGEETRPTLAEVLEQYLPSALAKESVTPYIAMLDEEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLGKGLGTKLVCALVEMLFKDAEVTKIQTDPSPNNLRAIRCYEKAGFVAQRTINTPDGPAVYMVQTRQAFEQARSAV", "dna_sequence_from_broadstreet": "ATGACCGAGCACGACCTTCCGATGCTCCATGACTGGCTAAATCGGCCTCACATCGTTGAGTGGTGGGGCGGAGAAGAAACACGTCCAACACTTGCTGAAGTGCTGGAGCAATACCTACCAAGCGCCCTGGCGAAAGAGTCCGTCACTCCCTACATCGCAATGCTGGATGAAGAACCGATTGGGTACGCTCAGTCGTACATTGCACTCGGAAGCGGTGACGGATGGTGGGAAGACGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCTCTGGCGAATCCATCGCAGCTGGGCAAGGGCTTGGGAACCAAGCTCGTTTGCGCGCTCGTTGAGATGCTGTTCAAAGACGCTGAGGTAACCAAGATCCAAACGGACCCGTCGCCGAACAACTTACGCGCAATCCGGTGCTACGAGAAGGCGGGTTTTGTGGCGCAAAGAACCATAAACACCCCAGATGGACCGGCCGTATACATGGTTCAAACACGTCAGGCGTTCGAGCAGGCGCGCAGTGCTGTCTAA", "partial": "0", "query_start": 1190, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 84.62}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "730", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.33726e-13, "max_identities": 22, "bit_score": 56.225, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGED", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 57.89}, "gnl|BL_ORD_ID|1714|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ie-APH(2'')-Ia", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "1814", "ARO_accession": "3002597", "ARO_name": "AAC(6')-Ie-APH(2'')-Ia", "ARO_category": {"36267": {"category_aro_accession": "3000128", "category_aro_cvterm_id": "36267", "category_aro_name": "APH(2'')", "category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0252516, "max_identities": 7, "bit_score": 26.9498, "cvterm_id": "35508", "query": "DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+ + +R + + D  ++ +WL    ++E++GG +", "sequence_from_db": "NEICIRTLIDDDFPLMLKWLTDERVLEFYGGRD", "sequence_from_broadstreet": "MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD", "dna_sequence_from_broadstreet": "ATGAATATAGTTGAAAATGAAATATGTATAAGAACTTTAATAGATGATGATTTTCCTTTGATGTTAAAATGGTTAACTGATGAAAGAGTATTAGAATTTTATGGTGGTAGAGATAAAAAATATACATTAGAATCATTAAAAAAACATTATACAGAGCCTTGGGAAGATGAAGTTTTTAGAGTAATTATTGAATATAACAATGTTCCTATTGGATATGGACAAATATATAAAATGTATGATGAGTTATATACTGATTATCATTATCCAAAAACTGATGAGATAGTCTATGGTATGGATCAATTTATAGGAGAGCCAAATTATTGGAGTAAAGGAATTGGTACAAGATATATTAAATTGATTTTTGAATTTTTGAAAAAAGAAAGAAATGCTAATGCAGTTATTTTAGACCCTCATAAAAATAATCCAAGAGCAATAAGGGCATACCAAAAATCTGGTTTTAGAATTATTGAAGATTTGCCAGAACATGAATTACACGAGGGCAAAAAAGAAGATTGTTATTTAATGGAATATAGATATGATGATAATGCCACAAATGTTAAGGCAATGAAATATTTAATTGAGCATTACTTTGATAATTTCAAAGTAGATAGTATTGAAATAATCGGTAGTGGTTATGATAGTGTGGCATATTTAGTTAATAATGAATACATTTTTAAAACAAAATTTAGTACTAATAAGAAAAAAGGTTATGCAAAAGAAAAAGCAATATATAATTTTTTAAATACAAATTTAGAAACTAATGTAAAAATTCCTAATATTGAATATTCGTATATTAGTGATGAATTATCTATACTAGGTTATAAAGAAATTAAAGGAACTTTTTTAACACCAGAAATTTATTCTACTATGTCAGAAGAAGAACAAAATTTGTTAAAACGAGATATTGCCAGTTTTTTAAGACAAATGCACGGTTTAGATTATACAGATATTAGTGAATGTACTATTGATAATAAACAAAATGTATTAGAAGAGTATATATTGTTGCGTGAAACTATTTATAATGATTTAACTGATATAGAAAAAGATTATATAGAAAGTTTTATGGAAAGACTAAATGCAACAACAGTTTTTGAGGGTAAAAAGTGTTTATGCCATAATGATTTTAGTTGTAATCATCTATTGTTAGATGGCAATAATAGATTAACTGGAATAATTGATTTTGGAGATTCTGGAATTATAGATGAATATTGTGATTTTATATACTTACTTGAAGATAGTGAAGAAGAAATAGGAACAAATTTTGGAGAAGATATATTAAGAATGTATGGAAATATAGATATTGAGAAAGCAAAAGAATATCAAGATATAGTTGAAGAATATTATCCTATTGAAACTATTGTTTATGGAATTAAAAATATTAAACAGGAATTTATCGAAAATGGTAGAAAAGAAATTTATAAAAGGACTTATAAAGATTGA", "partial": "0", "query_start": 1169, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 21.21}, "gnl|BL_ORD_ID|1698|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ErmY", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1797", "ARO_accession": "3002825", "ARO_name": "ErmY", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.430364, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "35508", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALLLMTEVDISIL", "sequence_from_broadstreet": "MNKKDIKFSQNFITSKRHINKIMSNLELNRNDNVFEIGSGKGHFTLELVQKCNYVTVIEIDSNLCIQTQNKVTNYDNFRIINKDILQFKFPNNKAYKIYGNIPYYISTDIVRKIVFESEATVSYLIVEEGFAKRLLNTNRSLALLLMTEVDISILSKIPKEYFHPKPKINSSLIILKRHPSKISYKDKKMYNNFVMKWVNQEYSKLFTKNQFNKALNYAKIKDLKNINFEQFLSVFNSYKLFNN", "dna_sequence_from_broadstreet": "ATGAACAAAAAAGATATAAAATTTAGTCAAAATTTTATTACTTCGAAACGACATATAAATAAAATAATGAGTAATTTAGAATTAAATAGAAATGATAATGTTTTTGAAATTGGTTCAGGAAAAGGGCATTTCACACTAGAACTGGTTCAAAAATGTAATTATGTAACAGTTATCGAGATAGATTCAAATTTATGTATTCAAACACAAAATAAAGTTACAAATTACGATAACTTTCGAATTATAAATAAGGATATATTACAGTTTAAGTTCCCAAACAACAAAGCATATAAAATCTACGGTAATATACCTTATTATATAAGTACGGATATAGTACGAAAAATTGTCTTTGAAAGTGAAGCAACAGTTAGTTACTTAATAGTTGAAGAAGGATTTGCTAAAAGGCTACTCAATACAAATCGTTCTCTAGCGTTACTTTTAATGACTGAAGTAGATATATCCATATTAAGTAAAATCCCTAAAGAATACTTTCATCCAAAGCCTAAAATTAATAGCTCTTTAATTATATTAAAAAGACACCCGTCAAAAATATCATACAAAGATAAAAAAATGTATAATAATTTTGTTATGAAATGGGTTAACCAAGAATACAGCAAACTATTTACCAAAAATCAGTTTAATAAAGCCTTAAATTATGCAAAAATAAAGGATTTAAAGAACATTAACTTCGAACAATTTTTATCAGTATTTAATAGCTATAAATTGTTTAATAACTAA", "partial": "0", "query_start": 1160, "query_end": 1216, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|1199|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ErmT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1275", "ARO_accession": "3000595", "ARO_name": "ErmT", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35946": {"category_aro_accession": "0000027", "category_aro_cvterm_id": "35946", "category_aro_name": "roxithromycin", "category_aro_description": "Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35964": {"category_aro_accession": "0000046", "category_aro_cvterm_id": "35964", "category_aro_name": "lincomycin", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.", "category_aro_class_name": "Antibiotic"}, "35974": {"category_aro_accession": "0000057", "category_aro_cvterm_id": "35974", "category_aro_name": "telithromycin", "category_aro_description": "Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35982": {"category_aro_accession": "0000065", "category_aro_cvterm_id": "35982", "category_aro_name": "clarithromycin", "category_aro_description": "Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections.", "category_aro_class_name": "Antibiotic"}, "35983": {"category_aro_accession": "0000066", "category_aro_cvterm_id": "35983", "category_aro_name": "clindamycin", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria.", "category_aro_class_name": "Antibiotic"}, "36284": {"category_aro_accession": "3000145", "category_aro_cvterm_id": "36284", "category_aro_name": "tylosin", "category_aro_description": "Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36315": {"category_aro_accession": "3000176", "category_aro_cvterm_id": "36315", "category_aro_name": "dirithromycin", "category_aro_description": "Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36722": {"category_aro_accession": "3000583", "category_aro_cvterm_id": "36722", "category_aro_name": "pristinamycin IA", "category_aro_description": "Pristinamycin 1A is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains.", "category_aro_class_name": "Antibiotic"}, "36723": {"category_aro_accession": "3000584", "category_aro_cvterm_id": "36723", "category_aro_name": "quinupristin", "category_aro_description": "Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "37019": {"category_aro_accession": "3000675", "category_aro_cvterm_id": "37019", "category_aro_name": "pristinamycin IB", "category_aro_description": "Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group).", "category_aro_class_name": "Antibiotic"}, "37021": {"category_aro_accession": "3000677", "category_aro_cvterm_id": "37021", "category_aro_name": "virginiamycin S2", "category_aro_description": "Virginiamycin S2 is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37022": {"category_aro_accession": "3000678", "category_aro_cvterm_id": "37022", "category_aro_name": "vernamycin B-gamma", "category_aro_description": "Vernamycin B-gamma is a class B streptogramin derived from virginiamycin S1.", "category_aro_class_name": "Antibiotic"}, "37023": {"category_aro_accession": "3000679", "category_aro_cvterm_id": "37023", "category_aro_name": "vernamycin C", "category_aro_description": "Vernamycin C is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37024": {"category_aro_accession": "3000680", "category_aro_cvterm_id": "37024", "category_aro_name": "patricin A", "category_aro_description": "Patricin A is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37025": {"category_aro_accession": "3000681", "category_aro_cvterm_id": "37025", "category_aro_name": "patricin B", "category_aro_description": "Patricin B is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37026": {"category_aro_accession": "3000682", "category_aro_cvterm_id": "37026", "category_aro_name": "ostreogrycin B3", "category_aro_description": "Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid.", "category_aro_class_name": "Antibiotic"}, "37247": {"category_aro_accession": "3000867", "category_aro_cvterm_id": "37247", "category_aro_name": "oleandomycin", "category_aro_description": "Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.466262, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "36841", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALFLMTEVDISIL", "sequence_from_broadstreet": "MNKKNIKDSQNFITSKHHINEILRNVHLNTNDNIIEIGSGKGHFSFELAKRCNYVTAIEIDPKLCRITKNKLIEYENFQVINKDILQFKFPKNKSYKIFGNIPYNISTDIIRKIVFESTATESYLIVEYGFAKRLLNTNRSLALFLMTEVDISILSKIPREYFHPKPRVNSSLIVLKRHPSKISLKDRKQYENFVMKWVNKEYIKLFSKNQFYQALKYARIDDLNNISFEQFLSLFNSYKLFNR", "dna_sequence_from_broadstreet": "ATGAACAAAAAAAATATAAAAGATAGTCAAAACTTTATTACTTCAAAGCATCATATAAATGAAATTTTGAGAAATGTACATTTAAATACAAATGATAATATTATTGAGATTGGTTCAGGGAAAGGTCATTTCTCGTTTGAATTAGCTAAAAGGTGTAATTATGTAACCGCCATTGAAATAGATCCTAAATTATGTAGGATAACTAAAAACAAACTTATTGAATATGAGAACTTCCAGGTTATCAATAAAGATATTTTACAATTTAAGTTTCCTAAAAATAAGTCATATAAGATATTTGGAAATATACCCTACAATATAAGTACAGATATAATTCGAAAAATTGTTTTTGAAAGCACAGCTACAGAAAGTTATTTAATAGTGGAATATGGATTTGCTAAAAGGTTGCTAAATACAAATCGTTCACTAGCACTATTTTTAATGACAGAAGTTGATATATCCATATTAAGTAAAATCCCTAGAGAATACTTTCATCCAAAACCTAGAGTTAATAGCTCGTTAATTGTATTAAAAAGACACCCTTCAAAAATATCACTCAAAGATAGAAAACAATATGAAAATTTTGTTATGAAATGGGTTAACAAAGAATACATAAAACTATTTTCCAAAAACCAATTTTATCAAGCCTTAAAATATGCAAGAATTGACGATTTAAACAATATTAGCTTTGAACAATTCTTGTCTCTTTTCAATAGCTATAAATTATTTAATAGATAA", "partial": "0", "query_start": 1160, "query_end": 1216, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|2493|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "Nocardia rifampin resistant beta-subunit of RNA polymerase (rpoB2)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "2200", "model_id": "2831", "ARO_accession": "3000501", "ARO_name": "rpoB2", "ARO_category": {"36349": {"category_aro_accession": "3000210", "category_aro_cvterm_id": "36349", "category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin.", "category_aro_class_name": "AMR Gene Family"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36656": {"category_aro_accession": "3000517", "category_aro_cvterm_id": "36656", "category_aro_name": "rifaximin", "category_aro_description": "Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase.", "category_aro_class_name": "Antibiotic"}, "36669": {"category_aro_accession": "3000530", "category_aro_cvterm_id": "36669", "category_aro_name": "rifabutin", "category_aro_description": "Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis.", "category_aro_class_name": "Antibiotic"}, "36673": {"category_aro_accession": "3000534", "category_aro_cvterm_id": "36673", "category_aro_name": "rifapentine", "category_aro_description": "Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy.", "category_aro_class_name": "Antibiotic"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.821022, "max_identities": 10, "bit_score": 22.7126, "cvterm_id": "41346", "query": "RLMTEHDLAMLYEWLNRSHIVE", "match": "R++TE D+A   E+L R H  E", "sequence_from_db": "RVLTEDDIAATIEYLVRLHAGE", "sequence_from_broadstreet": "MLEGRIVTVSSRTESPLAAPGVPGAPRRLSFARIREPLAVPGLLDIQTESFGWLIGAPDWCARAAARGTEPVAGLAEVLAEISPIEDFAGTMSLTLSDPRFEEVKASVEECKDKDLTYAAPWFVTAEFVNNNTGEIKSQTVFMGDFPMMTAHGTFVVNGTERVVVSQLVRSPGVYFDHAIDKGSEKDVHSARVIPSRGAWLEFDVDKRDTLGVRIDRKRRQPVTVLLKALGWSAERIAERFGFAPLIMASLAKDNVAGTDDALLEIHRKLRPGEPPTKESAQNLLANLFFTEKRYDLARVGRYKIDKKLGLRAPGAPRVLTEDDIAATIEYLVRLHAGERTMIAPGGVEVPVEVDDIDHFGNRRVRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQSLMNIRPVVAAMKEFFGTSQLSQFMDQRNPLASLTNKRRLSALGPGGLSRERAGLEVRDVHYSHYGRMCPIETPEGPNIGLMGYLSVYARVNPFGFVETPYRRVVDGRVTDEVDYLTADEEDRHVVAQANEPLDAEGRFLAARIPVRRKNSEVELVDSAAVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLIRSEAPIVGTGMELRAAVDAGDVVVNEKAGVVEEVSADYVTVMADDGTRKSYRMRKFNRSNQGTCSNQRPIVDEGQRVEAGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEQDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDDLPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPTEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWIGKAGWKVEGNPEWAKDLPEEMWEAPADSNIATPVFDGAREEELTGLLGSTLPNRDGERMVDDNGKAVLFDGRSGEPFPYPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGDNIPEPGVPESFKVLLKELQALCLNVEVLSAGAAVELAHGVDDDHERTAANLGINLSRAESITETELSG", "dna_sequence_from_broadstreet": "GTGCTGGAAGGACGCATCGTGACAGTCTCGAGTCGGACCGAGTCCCCGCTCGCCGCGCCCGGAGTCCCGGGTGCGCCCCGGCGGCTCTCGTTCGCCAGAATCCGCGAGCCCCTGGCGGTTCCGGGCCTGCTGGACATTCAGACCGAATCGTTCGGGTGGCTGATCGGCGCACCCGACTGGTGCGCCCGCGCGGCAGCCCGCGGGACGGAACCGGTCGCCGGGCTGGCCGAGGTGCTCGCCGAGATCAGCCCCATCGAGGACTTCGCGGGCACGATGTCGCTGACGTTGTCCGATCCGCGGTTCGAGGAGGTCAAGGCCTCCGTCGAGGAGTGCAAGGACAAGGATCTGACCTATGCCGCGCCGTGGTTCGTCACGGCGGAATTCGTGAACAACAACACCGGCGAGATCAAGAGCCAGACCGTTTTCATGGGTGATTTCCCCATGATGACCGCGCACGGGACATTCGTCGTCAACGGCACCGAACGGGTGGTCGTGTCGCAACTGGTGCGCTCGCCGGGCGTGTACTTCGACCACGCGATCGACAAGGGTTCGGAGAAGGACGTGCACAGCGCGCGGGTGATCCCGTCGCGCGGTGCCTGGCTGGAGTTCGACGTCGACAAGCGCGACACCCTGGGCGTGCGCATCGACCGCAAGCGCCGTCAGCCGGTAACGGTGCTGCTCAAGGCGCTGGGCTGGAGTGCGGAGCGAATCGCCGAGCGATTCGGGTTCGCCCCGCTGATCATGGCCTCGCTGGCCAAGGACAACGTGGCGGGCACCGACGACGCTTTGCTCGAGATCCATCGCAAGCTGCGTCCGGGCGAGCCGCCGACCAAGGAGTCGGCACAGAACCTGCTGGCAAATCTGTTCTTCACCGAGAAGCGCTACGACCTGGCGCGGGTGGGCCGTTACAAGATCGACAAGAAGCTCGGGCTGCGCGCTCCGGGGGCACCGCGGGTGCTCACCGAGGACGACATCGCGGCCACCATCGAGTACCTGGTGCGCCTGCACGCCGGGGAGAGGACGATGATCGCGCCCGGCGGGGTCGAGGTGCCGGTGGAGGTCGACGACATCGACCATTTCGGTAACCGCCGGGTGCGCACCGTGGGTGAGCTGATCCAGAACCAGATCCGCGTGGGTCTGTCCCGGATGGAACGGGTGGTGCGGGAGCGCATGACCACCCAGGACGTCGAGGCGATCACGCCGCAGTCGCTGATGAACATCCGCCCGGTGGTCGCGGCGATGAAGGAGTTCTTCGGCACCTCGCAGCTGTCGCAGTTCATGGACCAGCGCAACCCGCTGGCGAGCCTGACCAACAAGCGGCGGCTGTCCGCGCTCGGGCCGGGCGGGCTCTCGCGCGAACGGGCCGGCTTGGAGGTCCGCGACGTGCACTACAGCCACTACGGCCGGATGTGCCCGATCGAGACGCCGGAGGGGCCGAACATCGGCCTGATGGGGTACCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGTTTCGTCGAGACCCCCTACCGGCGGGTGGTGGACGGCCGGGTCACCGACGAGGTCGATTACCTCACCGCCGACGAGGAGGACCGGCACGTGGTGGCCCAGGCGAACGAACCGCTGGACGCCGAGGGCCGCTTCCTGGCCGCGCGAATCCCGGTGCGCCGGAAGAACTCCGAGGTGGAACTCGTCGATTCCGCCGCGGTGGATTACATGGATGTGTCGCCGCGGCAGATGGTGTCGGTGGCGACGGCGATGATTCCGTTCCTCGAGCATGATGATGCCAACCGTGCGCTGATGGGTGCGAATATGCAGCGTCAGGCGGTGCCGTTGATTCGGTCGGAGGCGCCGATCGTGGGTACCGGTATGGAGCTGCGTGCGGCGGTGGATGCCGGTGATGTGGTGGTGAACGAGAAGGCCGGTGTGGTCGAGGAGGTTTCGGCCGATTACGTCACGGTGATGGCCGATGACGGGACTCGTAAGTCGTATCGGATGCGGAAGTTCAACCGGTCGAATCAGGGGACGTGTTCGAATCAGCGGCCGATCGTGGACGAGGGTCAGCGGGTCGAGGCCGGGCAGGTGTTGGCTGATGGGCCGTGCACCGAGAACGGTGAGATGGCGCTGGGTAAGAACCTGTTGGTGGCGATCATGCCGTGGGAGGGGCACAACTACGAGGACGCGATCATCCTGTCGCAGCGGTTGGTGGAGCAGGATGTGTTGACCTCGATCCATATCGAGGAGCACGAGATCGATGCTCGTGACACCAAGCTCGGTGCCGAGGAGATCACTCGCGACATTCCGAATGTCTCCGATGAGGTGTTGGCGGATCTGGACGAGCGTGGCATCGTGCGGATCGGTGCGGAGGTGCGTGATGGTGACATCCTGGTCGGTAAGGTCACGCCCAAGGGTGAGACCGAGCTGACGCCGGAGGAGCGGTTGCTGCGGGCGATCTTCGGGGAGAAGGCGCGTGAGGTGCGTGATACCTCGTTGAAGGTGCCCCACGGTGAGTCGGGCAAGGTCATCGGGATCCGGGTGTTCTCTCGGGAGGACGATGACGATCTGCCGCCCGGTGTCAACGAGTTGGTGCGGGTGTATGTGGCGCAGAAGCGCAAGATCCAAGACGGTGACAAGCTGGCCGGTCGGCACGGGAACAAGGGTGTGATCGGCAAGATCCTGCCCACCGAGGACATGCCGTTCCTGCCCGATGGCACCCCGGTCGACATCATCCTCAACACCCACGGTGTGCCGCGGCGTATGAACATCGGCCAGATCCTGGAAACCCACCTCGGCTGGATCGGCAAAGCCGGCTGGAAGGTCGAGGGCAACCCCGAGTGGGCCAAGGATCTGCCGGAGGAGATGTGGGAGGCCCCCGCGGACTCCAACATCGCGACTCCGGTGTTCGACGGTGCCCGCGAGGAGGAGCTGACGGGTCTGCTGGGCTCGACGCTGCCCAACCGTGACGGTGAGCGGATGGTCGACGACAACGGCAAGGCCGTGCTGTTCGACGGTCGTTCCGGTGAGCCGTTCCCGTACCCGGTGGCGGTGGGCTACATGTACATCCTGAAGCTGCACCACCTGGTCGACGACAAGATCCACGCTCGCTCCACCGGCCCGTACTCGATGATCACCCAGCAGCCGCTCGGTGGTAAGGCCCAGTTCGGTGGCCAGCGCTTCGGTGAGATGGAGTGCTGGGCGATGCAGGCCTACGGCGCGGCCTACACCCTGCAGGAACTGCTCACGATCAAGTCCGACGACGTCGTCGGCCGCGTGAAGGTCTACGAGGCGATCGTCAAGGGCGACAACATCCCGGAACCCGGTGTGCCGGAATCGTTCAAGGTGTTGTTGAAGGAACTCCAGGCACTGTGCCTCAACGTCGAGGTGCTGTCCGCCGGTGCCGCGGTCGAACTGGCGCACGGGGTCGACGACGATCACGAGCGGACGGCCGCGAACCTCGGCATCAACCTGTCCCGCGCCGAATCCATCACGGAGACCGAGCTGTCCGGGTGA", "partial": "0", "query_start": 1184, "query_end": 1249, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 45.45}, "gnl|BL_ORD_ID|2301|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2525", "ARO_accession": "3003989", "ARO_name": "AAC(6')-34", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.998271, "max_identities": 8, "bit_score": 22.7126, "cvterm_id": "40862", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+T+R + E D   L  WL+   +++++ G +", "sequence_from_db": "ITVRELEEKDEISLASWLSNPDVLQYYEGRD", "sequence_from_broadstreet": "MRIGDLIREDGGIAMLVYEAGPITVRELEEKDEISLASWLSNPDVLQYYEGRDNPHDVERVREHFYVDDDETRCIIKYEGKPIGYIQFYLLDEETLGEYGYNESDADCRTFATDQFIGEPDYWNRGIGTKLMTSMVEYLVFQRQADRIVMDPQAWNERAIACYEKCGFRKVRLLEKHEQHEGELRDCWIMEYRAERK", "dna_sequence_from_broadstreet": "ATGAGAATTGGGGATCTAATAAGGGAAGATGGGGGGATCGCGATGCTGGTGTACGAGGCTGGACCGATTACGGTTCGCGAGCTGGAGGAGAAGGATGAAATATCCTTAGCTTCTTGGCTGTCCAATCCGGATGTGCTGCAGTATTATGAGGGACGGGACAATCCTCACGACGTGGAGCGGGTGCGGGAGCATTTTTACGTGGATGATGATGAGACTCGCTGCATCATTAAATATGAGGGGAAACCGATCGGATATATTCAGTTTTATCTTCTGGATGAAGAGACGTTAGGCGAGTATGGATATAACGAGAGTGATGCAGACTGCAGAACCTTCGCCACGGATCAATTCATCGGGGAGCCGGATTATTGGAATCGAGGCATCGGTACGAAGCTCATGACTTCCATGGTGGAGTATCTCGTGTTTCAGAGGCAGGCTGATCGGATCGTAATGGACCCGCAGGCATGGAATGAACGGGCGATTGCTTGTTACGAAAAGTGCGGCTTCCGGAAGGTCAGACTGCTGGAGAAGCATGAACAGCATGAAGGTGAACTGCGGGACTGCTGGATTATGGAGTATCGGGCAGAGCGAAAGTAA", "partial": "0", "query_start": 1175, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 25.81}, "gnl|BL_ORD_ID|1219|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "otr(A)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1273", "ARO_accession": "3002891", "ARO_name": "otr(A)", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.54342, "max_identities": 7, "bit_score": 21.557, "cvterm_id": "36773", "query": "LMTEHDLAMLYEWLNRSHIV", "match": "L+ +HD A L  +L+  H++", "sequence_from_db": "LLADHDDAFLTAYLDEEHVL", "sequence_from_broadstreet": "MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV", "dna_sequence_from_broadstreet": "ATGAACAAGCTGAATCTGGGCATCCTGGCCCACGTTGACGCCGGCAAGACCAGCCTCACCGAGCGCCTGCTGCACCGCACCGGTGTGATCGACGAGGTCGGCAGCGTGGACGCCGGCACCACGACGACCGACTCGATGGAGCTGGAGCGGCAGCGCGGCATCACCATCCGGTCCGCCGTGGCCACGTTCGTCCTGGACGATCTCAAGGTCAACCTCATCGACACCCCGGGCCACTCCGACTTCATCTCCGAGGTCGAGCGGGCGCTCGGGGTGCTCGACGGCGCGGTCCTGGTGGTCTCGGCCGTCGAGGGCGTCCAGCCGCAGACCCGCATCCTGATGCGGACCCTGCGCAGGCTGGGCATTCCCACGCTGGTCTTCGTCAACAAGATCGACCGGGGCGGCGCGCGTCCCGACGGTGTGCTGCGGGAGATCCGCGACCGGCTCACCCCCGCCGCGGTGGCACTGTCCGCCGTGGCGGACGCCGGCACGCCGCGGGCCCGCGCGATCGCGCTCGGCCCGGACACCGACCCGGACTTCGCCGTCCGGGTCGGTGAGCTGCTGGCCGACCACGACGACGCGTTCCTCACCGCCTACCTGGACGAGGAACACGTACTGACCGAGAAGGAGTACGCGGAGGAACTGGCCGCGCAGACCGCGCGCGGTCTGGTGCACCCGGTGTACTTCGGGTCCGCGCTGACCGGCGAGGGCCTGGACCATCTGGTGCACGGCATCCGGGAGTTGCTGCCGTCCGTGCACGCGTCGCAGGACGCGCCGCTGCGGGCCACCGTGTTCAAGGTGGACCGTGGCGCGCGCGGCGAGGCCGTCGCGTACCTGCGGCTGGTCTCCGGCACGCTGGGCACCCGCGATTCGGTGACGCTGCACCGCGTCGACCACACCGGCCGGGTCACCGAGCACGCCGGACGCATCACCGCGCTGCGGGTCTTCGAGCACGGGTCGGCCACCAGCGAGACCCGGGCGACCGCCGGGGACATCGCGCAGGCGTGGGGCCTGAAGGACGTACGGGTCGGTGACCGGGCCGGGCACCTCGACGGTCCCCCGCCGCGCAACTTCTTCGCGCCGCCCAGCCTGGAGACCGTGATCAGGCCGGAGCGCCCGGAGGAAGCGGGACGGCTGCACGCCGCGCTGCGCATGCTGGACGAGCAGGACCCCTCGATCGACCTGCGGCAGGACGAGGAGAACGCGGCCGGCGCGGTGGTCCGCCTCTACGGGGAGGTGCAGAAGGAGATCCTCGGCAGCACGCTCGCGGAGTCCTTCGGCGTACGGGTGCGCTTCGACCCGACCCGTACGGTCTGCATCGAAAAGCCCGTGGGGACCGGCGAGGCGCTGATCGAGCTGGACACGCGGACGCACAACTACTTCTGGGGCGCACCGTGGGTCTGCGCGTCGGACCGGCCGAGCCCGGCGCGGGCGATCACGTTCCGTTTGGCGGTGGAACTGGGCTCGCTCCCCCTGGCCTTCCACAAGGCCATCGAGGAGACGGTGCACACCACCCTGCGGCACGGTCTGTACGGCTGGCAGGTCACCGACTGCGCCGTCACCCTGACCCGTACCGGCGTTCGCAGTCCGGTCAGCGCGGCCGACGACTTCCGCAAGGCCAACGCGCGCTTGGTCCTGATGGACGCGCTCGGCAGGGCCGGTACGGAGGTGCACGAGCCGGTCAGCTCCTTCGAACTGGAGGTGCCCGCCGCCCGGCTCAGCCCGGTACTTGCGAAACTCGCGGAACTGGGCGCGACGCCCGGTGTGCCCACGGCCGAGGGGGACGTCTTCCGCCTGGAGGGCACGATGCCGACCAGCCTCGTGCACGACTTCAACCAGCGGGTTCCCGGACTGACCCAGGGCGAGGGCGTGTTCCTGGCCGAGCACCGGGGCTACCGGCCCGCCGTCGGACAGCCGCCCGTGCGGCCGCGGCCCGAGGGGCCCAACCCGCTCAACCGCGACGAGTACATCCTGCACGTGCTCAAGCGCGTGTGA", "partial": "0", "query_start": 1187, "query_end": 1246, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 35.0}, "gnl|BL_ORD_ID|2106|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "salA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1100", "model_id": "2265", "ARO_accession": "3003749", "ARO_name": "salA", "ARO_category": {"41687": {"category_aro_accession": "3004469", "category_aro_cvterm_id": "41687", "category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins.", "category_aro_class_name": "AMR Gene Family"}, "37716": {"category_aro_accession": "3001317", "category_aro_cvterm_id": "37716", "category_aro_name": "pleuromutilin", "category_aro_description": "Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36218": {"category_aro_accession": "3000079", "category_aro_cvterm_id": "36218", "category_aro_name": "oxazolidinone antibiotic", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37014": {"category_aro_accession": "3000670", "category_aro_cvterm_id": "37014", "category_aro_name": "pleuromutilin antibiotic", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.26075, "max_identities": 8, "bit_score": 21.1718, "cvterm_id": "40406", "query": "MTEHDLAMLYEWLNRSHIVE", "match": "M E DL   Y+W    +I+E", "sequence_from_db": "MMEQDLTPYYDWTVMDYIIE", "sequence_from_broadstreet": "MLFLFEEKALEVEHKVLIPELTFSIEDHEHLAIVGVNGVGKSTLLKVIHQDQSVDSAMMEQDLTPYYDWTVMDYIIESYPEIAKIRLQLNHTDMINKYIELDGYIIEGEIVTEAKKLGIKEEQLEQKISTLSGGEQTKVSFLKVKMSKASLLLIDEPTNHMDLEMKEWLTKAFKQEQRAILFVSHDRTFLNETPDAILELSLDGAKKYIGKYDKYKQQKDIEHETLKLQYEKQQKEQAAIEETIKKYKAWYQKAEQSASVRSPYQQKQLSKLAKRFKSKEQQLNRKLDQEHIPNPHKKEKTFSIQHHNFKSHYLVQFNHVSFAYDNRKIFDDVSFYIKRNQNVIVEGRNGTGKSTLIKLILGELEPTKGDITVHPELEIGYFSQDFENLNMHHTVLDEILEIPEMKEADARTILASFYFDKDRINDVVETLSMGEKCRLQFVKLYFSNPHIMILDEPTNYFDIGMQENIIQLIQSFQGSVLIVSHDNYFKSQIKDQTWTIKNHQMTHENVQVKDPINTESMKHHLKELEQYTDERNRETEF", "dna_sequence_from_broadstreet": "ATGCTATTTTTATTTGAAGAAAAAGCATTAGAAGTTGAACATAAAGTATTAATACCCGAGTTGACTTTTTCAATAGAGGACCATGAACATTTAGCAATCGTTGGTGTTAATGGTGTTGGAAAATCAACATTATTAAAAGTCATTCATCAAGATCAATCAGTTGATTCAGCGATGATGGAACAAGATTTAACACCTTATTATGATTGGACTGTTATGGATTATATAATTGAATCATATCCTGAAATCGCAAAGATTAGATTGCAACTTAATCATACAGATATGATTAATAAATATATTGAATTAGATGGATACATTATAGAAGGTGAAATCGTAACAGAAGCAAAAAAGCTCGGAATAAAAGAGGAACAACTAGAACAGAAAATTTCTACTTTAAGTGGTGGAGAACAAACAAAAGTATCATTTTTAAAAGTGAAAATGTCTAAAGCATCATTACTATTAATCGATGAACCAACAAACCACATGGATTTAGAAATGAAGGAATGGTTGACGAAAGCTTTTAAACAAGAACAACGTGCTATATTATTTGTATCTCATGACCGAACATTTTTAAATGAAACGCCAGATGCTATATTAGAATTGAGTCTTGATGGGGCTAAGAAGTATATCGGTAAATACGATAAATACAAACAACAAAAAGATATAGAGCATGAAACATTAAAGCTACAGTATGAAAAACAACAAAAAGAACAAGCGGCCATTGAAGAAACGATTAAAAAATATAAAGCATGGTATCAAAAAGCAGAACAAAGTGCTTCTGTGAGAAGCCCATATCAACAAAAACAATTAAGTAAGTTAGCGAAACGGTTTAAATCAAAAGAACAACAATTAAATCGTAAACTTGATCAAGAGCATATCCCAAATCCACATAAAAAAGAGAAAACTTTCTCAATACAACATCATAATTTTAAATCACATTATTTAGTTCAATTTAATCATGTTTCGTTTGCTTATGATAACCGGAAAATATTCGATGATGTATCATTCTATATTAAGCGAAATCAAAATGTTATTGTTGAAGGCAGAAATGGTACAGGTAAATCAACTTTAATCAAATTGATACTCGGTGAACTCGAGCCAACTAAAGGTGATATAACTGTTCATCCAGAATTAGAAATTGGATATTTCTCTCAAGATTTTGAGAATTTAAATATGCATCATACTGTCTTAGATGAAATATTAGAAATTCCTGAAATGAAAGAAGCAGATGCAAGAACCATATTAGCAAGCTTTTATTTTGATAAAGATAGGATAAATGATGTTGTTGAAACACTATCGATGGGTGAAAAATGTAGGTTACAATTTGTAAAATTATATTTTTCAAATCCTCATATTATGATATTAGATGAGCCAACAAACTATTTCGATATTGGCATGCAAGAAAATATCATTCAATTAATACAATCATTTCAAGGTTCGGTCCTTATTGTATCTCATGATAATTATTTTAAATCACAAATTAAAGATCAGACTTGGACTATAAAAAATCATCAAATGACGCATGAAAATGTTCAAGTCAAAGATCCTATTAATACAGAATCTATGAAACATCATTTAAAAGAATTAGAACAATATACAGATGAAAGAAATCGTGAAACAGAGTTCTAG", "partial": "0", "query_start": 1190, "query_end": 1249, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 40.0}, "gnl|BL_ORD_ID|2095|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03791, "max_identities": 9, "bit_score": 20.7866, "cvterm_id": "42594", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 1175, "query_end": 1228, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2094|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03791, "max_identities": 9, "bit_score": 20.7866, "cvterm_id": "40382", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 1175, "query_end": 1228, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}}, "NODE_57_length_1134_cov_34.8908_1 # 25 # 864 # -1 # ID=57_1;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.615": {"gnl|BL_ORD_ID|1003|hsp_num:0": {"type_match": "Perfect", "model_id": "1070", "orf_strand": "-", "orf_start": 25, "orf_end": 864, "orf_from": "NODE_57_length_1134_cov_34.8908_1", "model_name": "sul1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000410", "ARO_name": "sul1", "ARO_category": {"41402": {"category_aro_accession": "3004238", "category_aro_cvterm_id": "41402", "category_aro_name": "sulfonamide resistant sul", "category_aro_description": "The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide.", "category_aro_class_name": "AMR Gene Family"}, "36463": {"category_aro_accession": "3000324", "category_aro_cvterm_id": "36463", "category_aro_name": "sulfadiazine", "category_aro_description": "Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "36464": {"category_aro_accession": "3000325", "category_aro_cvterm_id": "36464", "category_aro_name": "sulfadimidine", "category_aro_description": "Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36466": {"category_aro_accession": "3000327", "category_aro_cvterm_id": "36466", "category_aro_name": "sulfadoxine", "category_aro_description": "Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36469": {"category_aro_accession": "3000330", "category_aro_cvterm_id": "36469", "category_aro_name": "sulfisoxazole", "category_aro_description": "Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "37027": {"category_aro_accession": "3000683", "category_aro_cvterm_id": "37027", "category_aro_name": "sulfacetamide", "category_aro_description": "Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability.", "category_aro_class_name": "Antibiotic"}, "37028": {"category_aro_accession": "3000684", "category_aro_cvterm_id": "37028", "category_aro_name": "mafenide", "category_aro_description": "Mafenide is a sulfonamide used topically for treating burns.", "category_aro_class_name": "Antibiotic"}, "37042": {"category_aro_accession": "3000698", "category_aro_cvterm_id": "37042", "category_aro_name": "sulfasalazine", "category_aro_description": "Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis.", "category_aro_class_name": "Antibiotic"}, "37043": {"category_aro_accession": "3000699", "category_aro_cvterm_id": "37043", "category_aro_name": "sulfamethizole", "category_aro_description": "Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase.", "category_aro_class_name": "Antibiotic"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 553.132, "max_identities": 279, "cvterm_id": "39525", "query": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "match": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "sequence_from_db": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "sequence_from_broadstreet": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "dna_sequence_from_broadstreet": "ATGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTCGATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGAGTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTATCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATGCACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGCGTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCTGAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGCACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGGGTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTCGATCCGGGGATGGGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAGCTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGCGCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCACGCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCAATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTAGATCATGCCTAG", "partial": "0", "query_start": 25, "query_end": 861, "orf_dna_sequence": "ATGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTCGATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGAGTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTATCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATGCACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGCGTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCTGAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGCACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGGGTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTAGATCCGGGGATGGGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAGCTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGCGCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCACGCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCAATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTAGATCATGCCTAG", "orf_prot_sequence": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "perc_identity": 100.0}}, "NODE_69_length_625_cov_55.4398_1 # 63 # 623 # -1 # ID=69_1;partial=01;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.542": {"gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1370", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.16864e-140, "bit_score": 385.185, "max_identities": 186, "cvterm_id": "36752", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 100.0}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "993", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.39704e-139, "bit_score": 382.874, "max_identities": 185, "cvterm_id": "36752", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.46}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1068", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.74224e-138, "bit_score": 379.022, "max_identities": 183, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.46}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2071", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33948e-137, "bit_score": 380.178, "max_identities": 184, "cvterm_id": "36884", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.92}, "gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1678", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.66084e-137, "bit_score": 377.867, "max_identities": 184, "cvterm_id": "35914", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDG WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTP GPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.92}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1002", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.84326e-137, "bit_score": 376.326, "max_identities": 182, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.91}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "63", "pass_evalue": "n/a", "pass_bitscore": "350", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.97025e-136, "bit_score": 375.555, "max_identities": 181, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFE+QGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.37}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1235", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.43592e-135, "bit_score": 373.629, "max_identities": 181, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRS A", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.37}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1801", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40982e-135, "bit_score": 373.244, "max_identities": 181, "cvterm_id": "35732", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+I  NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGID  LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "TIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 97.31}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "444", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.1426e-128, "bit_score": 354.755, "max_identities": 171, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTR DA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 105, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.42}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1000", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.18675e-127, "bit_score": 352.829, "max_identities": 170, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 105, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.84}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1577", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.23597e-106, "bit_score": 299.671, "max_identities": 142, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE RPTL +V + YLP VLA+E+VTPYIAML  EPIGYAQSYVALGSGDGWWE+ETDPGVRGIDQ L+N +QL +GLGTKLV+ALVELLF+DP VTKIQTDP+P+N RAIRCYEKAGF +Q  +TTPDGPAVYMVQTRQAFER RS A", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 77.17}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1657", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.22253e-104, "bit_score": 295.434, "max_identities": 140, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E RPTL +V E YLP  +A+ESVTPYIAML  EPIGYAQSYVALGSGDGWWE+ETDPGVRGIDQ LA+ +QL KGLGT+LVRALVELLF+DP VTKIQTDP+P+N RAIRCYEKAGF R+  +TTPDGPAVYMVQTRQAFER R  A", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 76.09}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "730", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.40724e-102, "bit_score": 288.886, "max_identities": 134, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRS", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+ RPTL +V E Y P VLA+++V PYIAML+ EPIGYAQSY+ALGSGDGWWE+ETDPGVRGIDQ LAN SQL KGLGTKLVR+LVELLF+DP VTKIQTDPSPSN RAIRCYEKAGF ++  + TPDGPAVYMVQTRQAFE  R+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRT", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 69, "query_end": 614, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 73.63}}, "NODE_185_length_335_cov_33.8077_1 # 172 # 333 # 1 # ID=185_1;partial=01;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.494": {"gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1678", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.79463e-36, "max_identities": 54, "bit_score": 115.931, "cvterm_id": "35914", "query": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 172, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "993", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52072e-33, "max_identities": 51, "bit_score": 109.768, "cvterm_id": "36752", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1370", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.58816e-33, "max_identities": 51, "bit_score": 109.768, "cvterm_id": "36752", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1960|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "475", "model_id": "2117", "ARO_accession": "3002578", "ARO_name": "AAC(6')-Ib7", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.03278e-32, "max_identities": 51, "bit_score": 107.071, "cvterm_id": "35906", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MRSRNWSRTLTERSGGNGAVAVFMACYDCFFVQSMPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGCGCTCACGCAACTGGTCCAGAACCTTGACCGAACGCAGCGGTGGTAACGGCGCAGTGGCGGTTTTCATGGCTTGTTATGACTGTTTTTTTGTACAGTCTATGCCTCGGGCATCCAAGCAGCAAGCGCGTTACGCCGTGGGTCGATGTTTGATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2046|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "339", "ARO_accession": "3002598", "ARO_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "41439": {"category_aro_accession": "3004275", "category_aro_cvterm_id": "41439", "category_aro_name": "ANT(3'')", "category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.23962e-31, "max_identities": 50, "bit_score": 107.457, "cvterm_id": "36783", "query": "AKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 181, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 98.04, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2071", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.35836e-30, "max_identities": 47, "bit_score": 100.908, "cvterm_id": "36884", "query": "KLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "KLGITKYSIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "KLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 190, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.92, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|865|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "922", "ARO_accession": "3002599", "ARO_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.11286e-29, "max_identities": 47, "bit_score": 100.138, "cvterm_id": "36752", "query": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 193, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "63", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.02013e-24, "max_identities": 38, "bit_score": 85.1149, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|194|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(3)-Ib/AAC(6')-Ib''", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "209", "ARO_accession": "3002600", "ARO_name": "AAC(3)-Ib/AAC(6')-Ib''", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.77985e-24, "max_identities": 41, "bit_score": 87.0409, "cvterm_id": "36752", "query": "TKLGITKYSI------VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "TKLG+ +  +      +TNSNDSVTLRLMTEHDLAMLYEW+NRSHIVEWWGGEEA", "sequence_from_db": "TKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSIIATVKIGPDEISAMRAVLDLFGKEFEDIPTYSDRQPTNEYLANLLHSETFIALAAFDRGTAIGGLAAYVLPKFEQARSEIYIYDLAVASSHRRLGVATALISHLKRVAVELGAYVIYVQADYGDDPAVALYTKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGGGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCATCATTGCAACCGTCAAGATCGGCCCTGACGAAATTTCAGCCATGAGGGCTGTGCTCGATCTCTTCGGCAAAGAGTTTGAGGACATTCCAACCTACTCTGATCGCCAGCCGACCAATGAGTATCTTGCCAATCTTCTGCACAGCGAGACGTTCATCGCGCTCGCTGCTTTTGACCGCGGAACAGCAATAGGTGGGCTCGCAGCCTACGTTCTACCCAAGTTCGAGCAAGCGCGAAGCGAGATCTACATTTATGACTTGGCAGTCGCTTCCAGCCATCGAAGGCTAGGAGTCGCAACTGCCCTGATTAGCCACCTGAAGCGTGTGGCGGTTGAACTTGGCGCGTATGTAATCTATGTGCAAGCAGACTACGGTGACGATCCGGCAGTCGCTCTCTACACAAAGCTTGGAGTTCGGGAAGACGTCATGCACTTCGACATTGATCCATTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGGTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAGGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 187, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 74.55}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1801", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.1424e-24, "max_identities": 39, "bit_score": 84.3445, "cvterm_id": "35732", "query": "KYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "K +I  NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "KNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 205, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 90.7}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1068", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12083e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1235", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33203e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1002", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33203e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "444", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.41848e-16, "max_identities": 27, "bit_score": 64.3142, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 253, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1000", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.47733e-15, "max_identities": 26, "bit_score": 62.7734, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 253, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.3, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1577", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.00459e-15, "max_identities": 27, "bit_score": 62.003, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 71.05}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1657", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.44358e-15, "max_identities": 25, "bit_score": 61.6178, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDE", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 65.79}, "gnl|BL_ORD_ID|125|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIb", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "140", "ARO_accession": "3002595", "ARO_name": "AAC(6')-IIb", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.04725e-14, "max_identities": 24, "bit_score": 59.3066, "cvterm_id": "36937", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGE", "match": "VTLR MTE D+ ML+EWLNR HIVEWWGGE", "sequence_from_db": "VTLRPMTEDDIGMLHEWLNRPHIVEWWGGE", "sequence_from_broadstreet": "MHPGVVTLRPMTEDDIGMLHEWLNRPHIVEWWGGERPSLEEVKEDYRPSALAEEGVTPYIGLLDGTPFAFAQSYVALGSGGGWWEEETDPGVRGIDQSIADSGLLGRGYGTRLVQALVDLLFADPQVSKVQTDPSPNNMRAIRCYEKAGFRKVKVVSTPDGPAMYMLHERPLVNGLRSAA", "dna_sequence_from_broadstreet": "ATGCATCCCGGCGTTGTTACTCTGCGTCCGATGACCGAAGACGACATCGGTATGCTTCACGAATGGTTGAATCGGCCGCACATTGTCGAATGGTGGGGTGGTGAGCGGCCCTCGCTCGAAGAGGTGAAAGAGGACTATCGGCCCAGCGCGTTGGCCGAAGAAGGAGTGACGCCGTACATCGGTTTGCTTGACGGAACTCCATTCGCGTTCGCACAGTCGTACGTTGCGCTCGGGTCGGGTGGTGGATGGTGGGAGGAAGAGACCGATCCTGGTGTCCGCGGAATCGATCAATCAATCGCCGATTCCGGGCTTCTCGGAAGAGGTTACGGCACTCGGCTGGTGCAGGCGCTTGTTGATTTGCTGTTCGCCGACCCGCAGGTATCCAAGGTTCAGACGGACCCCTCCCCGAACAACATGCGCGCGATACGCTGCTATGAGAAGGCAGGCTTCCGGAAGGTCAAGGTCGTTTCAACACCGGATGGGCCGGCCATGTACATGTTGCACGAGCGTCCGTTGGTGAACGGTTTGCGCAGTGCGGCCTAA", "partial": "0", "query_start": 238, "query_end": 327, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 80.0}, "gnl|BL_ORD_ID|1024|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "325", "model_id": "1093", "ARO_accession": "3002585", "ARO_name": "AAC(6')-31", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.02019e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36803", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "MTEHDL ML++WLNR HIVEWWGGEE", "sequence_from_db": "MTEHDLPMLHDWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MTEHDLPMLHDWLNRPHIVEWWGGEETRPTLAEVLEQYLPSALAKESVTPYIAMLDEEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLGKGLGTKLVCALVEMLFKDAEVTKIQTDPSPNNLRAIRCYEKAGFVAQRTINTPDGPAVYMVQTRQAFEQARSAV", "dna_sequence_from_broadstreet": "ATGACCGAGCACGACCTTCCGATGCTCCATGACTGGCTAAATCGGCCTCACATCGTTGAGTGGTGGGGCGGAGAAGAAACACGTCCAACACTTGCTGAAGTGCTGGAGCAATACCTACCAAGCGCCCTGGCGAAAGAGTCCGTCACTCCCTACATCGCAATGCTGGATGAAGAACCGATTGGGTACGCTCAGTCGTACATTGCACTCGGAAGCGGTGACGGATGGTGGGAAGACGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCTCTGGCGAATCCATCGCAGCTGGGCAAGGGCTTGGGAACCAAGCTCGTTTGCGCGCTCGTTGAGATGCTGTTCAAAGACGCTGAGGTAACCAAGATCCAAACGGACCCGTCGCCGAACAACTTACGCGCAATCCGGTGCTACGAGAAGGCGGGTTTTGTGGCGCAAAGAACCATAAACACCCCAGATGGACCGGCCGTATACATGGTTCAAACACGTCAGGCGTTCGAGCAGGCGCGCAGTGCTGTCTAA", "partial": "0", "query_start": 253, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 84.62}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "730", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.87001e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGED", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 57.89}, "gnl|BL_ORD_ID|1714|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ie-APH(2'')-Ia", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "1814", "ARO_accession": "3002597", "ARO_name": "AAC(6')-Ie-APH(2'')-Ia", "ARO_category": {"36267": {"category_aro_accession": "3000128", "category_aro_cvterm_id": "36267", "category_aro_name": "APH(2'')", "category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.035308, "max_identities": 7, "bit_score": 26.9498, "cvterm_id": "35508", "query": "DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+ + +R + + D  ++ +WL    ++E++GG +", "sequence_from_db": "NEICIRTLIDDDFPLMLKWLTDERVLEFYGGRD", "sequence_from_broadstreet": "MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD", "dna_sequence_from_broadstreet": "ATGAATATAGTTGAAAATGAAATATGTATAAGAACTTTAATAGATGATGATTTTCCTTTGATGTTAAAATGGTTAACTGATGAAAGAGTATTAGAATTTTATGGTGGTAGAGATAAAAAATATACATTAGAATCATTAAAAAAACATTATACAGAGCCTTGGGAAGATGAAGTTTTTAGAGTAATTATTGAATATAACAATGTTCCTATTGGATATGGACAAATATATAAAATGTATGATGAGTTATATACTGATTATCATTATCCAAAAACTGATGAGATAGTCTATGGTATGGATCAATTTATAGGAGAGCCAAATTATTGGAGTAAAGGAATTGGTACAAGATATATTAAATTGATTTTTGAATTTTTGAAAAAAGAAAGAAATGCTAATGCAGTTATTTTAGACCCTCATAAAAATAATCCAAGAGCAATAAGGGCATACCAAAAATCTGGTTTTAGAATTATTGAAGATTTGCCAGAACATGAATTACACGAGGGCAAAAAAGAAGATTGTTATTTAATGGAATATAGATATGATGATAATGCCACAAATGTTAAGGCAATGAAATATTTAATTGAGCATTACTTTGATAATTTCAAAGTAGATAGTATTGAAATAATCGGTAGTGGTTATGATAGTGTGGCATATTTAGTTAATAATGAATACATTTTTAAAACAAAATTTAGTACTAATAAGAAAAAAGGTTATGCAAAAGAAAAAGCAATATATAATTTTTTAAATACAAATTTAGAAACTAATGTAAAAATTCCTAATATTGAATATTCGTATATTAGTGATGAATTATCTATACTAGGTTATAAAGAAATTAAAGGAACTTTTTTAACACCAGAAATTTATTCTACTATGTCAGAAGAAGAACAAAATTTGTTAAAACGAGATATTGCCAGTTTTTTAAGACAAATGCACGGTTTAGATTATACAGATATTAGTGAATGTACTATTGATAATAAACAAAATGTATTAGAAGAGTATATATTGTTGCGTGAAACTATTTATAATGATTTAACTGATATAGAAAAAGATTATATAGAAAGTTTTATGGAAAGACTAAATGCAACAACAGTTTTTGAGGGTAAAAAGTGTTTATGCCATAATGATTTTAGTTGTAATCATCTATTGTTAGATGGCAATAATAGATTAACTGGAATAATTGATTTTGGAGATTCTGGAATTATAGATGAATATTGTGATTTTATATACTTACTTGAAGATAGTGAAGAAGAAATAGGAACAAATTTTGGAGAAGATATATTAAGAATGTATGGAAATATAGATATTGAGAAAGCAAAAGAATATCAAGATATAGTTGAAGAATATTATCCTATTGAAACTATTGTTTATGGAATTAAAAATATTAAACAGGAATTTATCGAAAATGGTAGAAAAGAAATTTATAAAAGGACTTATAAAGATTGA", "partial": "0", "query_start": 232, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 21.21}, "gnl|BL_ORD_ID|1199|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ErmT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1275", "ARO_accession": "3000595", "ARO_name": "ErmT", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35946": {"category_aro_accession": "0000027", "category_aro_cvterm_id": "35946", "category_aro_name": "roxithromycin", "category_aro_description": "Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35964": {"category_aro_accession": "0000046", "category_aro_cvterm_id": "35964", "category_aro_name": "lincomycin", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.", "category_aro_class_name": "Antibiotic"}, "35974": {"category_aro_accession": "0000057", "category_aro_cvterm_id": "35974", "category_aro_name": "telithromycin", "category_aro_description": "Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35982": {"category_aro_accession": "0000065", "category_aro_cvterm_id": "35982", "category_aro_name": "clarithromycin", "category_aro_description": "Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections.", "category_aro_class_name": "Antibiotic"}, "35983": {"category_aro_accession": "0000066", "category_aro_cvterm_id": "35983", "category_aro_name": "clindamycin", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria.", "category_aro_class_name": "Antibiotic"}, "36284": {"category_aro_accession": "3000145", "category_aro_cvterm_id": "36284", "category_aro_name": "tylosin", "category_aro_description": "Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36315": {"category_aro_accession": "3000176", "category_aro_cvterm_id": "36315", "category_aro_name": "dirithromycin", "category_aro_description": "Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36722": {"category_aro_accession": "3000583", "category_aro_cvterm_id": "36722", "category_aro_name": "pristinamycin IA", "category_aro_description": "Pristinamycin 1A is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains.", "category_aro_class_name": "Antibiotic"}, "36723": {"category_aro_accession": "3000584", "category_aro_cvterm_id": "36723", "category_aro_name": "quinupristin", "category_aro_description": "Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "37019": {"category_aro_accession": "3000675", "category_aro_cvterm_id": "37019", "category_aro_name": "pristinamycin IB", "category_aro_description": "Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group).", "category_aro_class_name": "Antibiotic"}, "37021": {"category_aro_accession": "3000677", "category_aro_cvterm_id": "37021", "category_aro_name": "virginiamycin S2", "category_aro_description": "Virginiamycin S2 is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37022": {"category_aro_accession": "3000678", "category_aro_cvterm_id": "37022", "category_aro_name": "vernamycin B-gamma", "category_aro_description": "Vernamycin B-gamma is a class B streptogramin derived from virginiamycin S1.", "category_aro_class_name": "Antibiotic"}, "37023": {"category_aro_accession": "3000679", "category_aro_cvterm_id": "37023", "category_aro_name": "vernamycin C", "category_aro_description": "Vernamycin C is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37024": {"category_aro_accession": "3000680", "category_aro_cvterm_id": "37024", "category_aro_name": "patricin A", "category_aro_description": "Patricin A is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37025": {"category_aro_accession": "3000681", "category_aro_cvterm_id": "37025", "category_aro_name": "patricin B", "category_aro_description": "Patricin B is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37026": {"category_aro_accession": "3000682", "category_aro_cvterm_id": "37026", "category_aro_name": "ostreogrycin B3", "category_aro_description": "Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid.", "category_aro_class_name": "Antibiotic"}, "37247": {"category_aro_accession": "3000867", "category_aro_cvterm_id": "37247", "category_aro_name": "oleandomycin", "category_aro_description": "Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.643841, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "36841", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALFLMTEVDISIL", "sequence_from_broadstreet": "MNKKNIKDSQNFITSKHHINEILRNVHLNTNDNIIEIGSGKGHFSFELAKRCNYVTAIEIDPKLCRITKNKLIEYENFQVINKDILQFKFPKNKSYKIFGNIPYNISTDIIRKIVFESTATESYLIVEYGFAKRLLNTNRSLALFLMTEVDISILSKIPREYFHPKPRVNSSLIVLKRHPSKISLKDRKQYENFVMKWVNKEYIKLFSKNQFYQALKYARIDDLNNISFEQFLSLFNSYKLFNR", "dna_sequence_from_broadstreet": "ATGAACAAAAAAAATATAAAAGATAGTCAAAACTTTATTACTTCAAAGCATCATATAAATGAAATTTTGAGAAATGTACATTTAAATACAAATGATAATATTATTGAGATTGGTTCAGGGAAAGGTCATTTCTCGTTTGAATTAGCTAAAAGGTGTAATTATGTAACCGCCATTGAAATAGATCCTAAATTATGTAGGATAACTAAAAACAAACTTATTGAATATGAGAACTTCCAGGTTATCAATAAAGATATTTTACAATTTAAGTTTCCTAAAAATAAGTCATATAAGATATTTGGAAATATACCCTACAATATAAGTACAGATATAATTCGAAAAATTGTTTTTGAAAGCACAGCTACAGAAAGTTATTTAATAGTGGAATATGGATTTGCTAAAAGGTTGCTAAATACAAATCGTTCACTAGCACTATTTTTAATGACAGAAGTTGATATATCCATATTAAGTAAAATCCCTAGAGAATACTTTCATCCAAAACCTAGAGTTAATAGCTCGTTAATTGTATTAAAAAGACACCCTTCAAAAATATCACTCAAAGATAGAAAACAATATGAAAATTTTGTTATGAAATGGGTTAACAAAGAATACATAAAACTATTTTCCAAAAACCAATTTTATCAAGCCTTAAAATATGCAAGAATTGACGATTTAAACAATATTAGCTTTGAACAATTCTTGTCTCTTTTCAATAGCTATAAATTATTTAATAGATAA", "partial": "0", "query_start": 223, "query_end": 279, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|1698|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ErmY", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1797", "ARO_accession": "3002825", "ARO_name": "ErmY", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.683681, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "35508", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALLLMTEVDISIL", "sequence_from_broadstreet": "MNKKDIKFSQNFITSKRHINKIMSNLELNRNDNVFEIGSGKGHFTLELVQKCNYVTVIEIDSNLCIQTQNKVTNYDNFRIINKDILQFKFPNNKAYKIYGNIPYYISTDIVRKIVFESEATVSYLIVEEGFAKRLLNTNRSLALLLMTEVDISILSKIPKEYFHPKPKINSSLIILKRHPSKISYKDKKMYNNFVMKWVNQEYSKLFTKNQFNKALNYAKIKDLKNINFEQFLSVFNSYKLFNN", "dna_sequence_from_broadstreet": "ATGAACAAAAAAGATATAAAATTTAGTCAAAATTTTATTACTTCGAAACGACATATAAATAAAATAATGAGTAATTTAGAATTAAATAGAAATGATAATGTTTTTGAAATTGGTTCAGGAAAAGGGCATTTCACACTAGAACTGGTTCAAAAATGTAATTATGTAACAGTTATCGAGATAGATTCAAATTTATGTATTCAAACACAAAATAAAGTTACAAATTACGATAACTTTCGAATTATAAATAAGGATATATTACAGTTTAAGTTCCCAAACAACAAAGCATATAAAATCTACGGTAATATACCTTATTATATAAGTACGGATATAGTACGAAAAATTGTCTTTGAAAGTGAAGCAACAGTTAGTTACTTAATAGTTGAAGAAGGATTTGCTAAAAGGCTACTCAATACAAATCGTTCTCTAGCGTTACTTTTAATGACTGAAGTAGATATATCCATATTAAGTAAAATCCCTAAAGAATACTTTCATCCAAAGCCTAAAATTAATAGCTCTTTAATTATATTAAAAAGACACCCGTCAAAAATATCATACAAAGATAAAAAAATGTATAATAATTTTGTTATGAAATGGGTTAACCAAGAATACAGCAAACTATTTACCAAAAATCAGTTTAATAAAGCCTTAAATTATGCAAAAATAAAGGATTTAAAGAACATTAACTTCGAACAATTTTTATCAGTATTTAATAGCTATAAATTGTTTAATAACTAA", "partial": "0", "query_start": 223, "query_end": 279, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|2301|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2525", "ARO_accession": "3003989", "ARO_name": "AAC(6')-34", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.07752, "max_identities": 8, "bit_score": 22.7126, "cvterm_id": "40862", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+T+R + E D   L  WL+   +++++ G +", "sequence_from_db": "ITVRELEEKDEISLASWLSNPDVLQYYEGRD", "sequence_from_broadstreet": "MRIGDLIREDGGIAMLVYEAGPITVRELEEKDEISLASWLSNPDVLQYYEGRDNPHDVERVREHFYVDDDETRCIIKYEGKPIGYIQFYLLDEETLGEYGYNESDADCRTFATDQFIGEPDYWNRGIGTKLMTSMVEYLVFQRQADRIVMDPQAWNERAIACYEKCGFRKVRLLEKHEQHEGELRDCWIMEYRAERK", "dna_sequence_from_broadstreet": "ATGAGAATTGGGGATCTAATAAGGGAAGATGGGGGGATCGCGATGCTGGTGTACGAGGCTGGACCGATTACGGTTCGCGAGCTGGAGGAGAAGGATGAAATATCCTTAGCTTCTTGGCTGTCCAATCCGGATGTGCTGCAGTATTATGAGGGACGGGACAATCCTCACGACGTGGAGCGGGTGCGGGAGCATTTTTACGTGGATGATGATGAGACTCGCTGCATCATTAAATATGAGGGGAAACCGATCGGATATATTCAGTTTTATCTTCTGGATGAAGAGACGTTAGGCGAGTATGGATATAACGAGAGTGATGCAGACTGCAGAACCTTCGCCACGGATCAATTCATCGGGGAGCCGGATTATTGGAATCGAGGCATCGGTACGAAGCTCATGACTTCCATGGTGGAGTATCTCGTGTTTCAGAGGCAGGCTGATCGGATCGTAATGGACCCGCAGGCATGGAATGAACGGGCGATTGCTTGTTACGAAAAGTGCGGCTTCCGGAAGGTCAGACTGCTGGAGAAGCATGAACAGCATGAAGGTGAACTGCGGGACTGCTGGATTATGGAGTATCGGGCAGAGCGAAAGTAA", "partial": "0", "query_start": 238, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 25.81}, "gnl|BL_ORD_ID|2493|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "Nocardia rifampin resistant beta-subunit of RNA polymerase (rpoB2)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "2200", "model_id": "2831", "ARO_accession": "3000501", "ARO_name": "rpoB2", "ARO_category": {"36349": {"category_aro_accession": "3000210", "category_aro_cvterm_id": "36349", "category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin.", "category_aro_class_name": "AMR Gene Family"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36656": {"category_aro_accession": "3000517", "category_aro_cvterm_id": "36656", "category_aro_name": "rifaximin", "category_aro_description": "Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase.", "category_aro_class_name": "Antibiotic"}, "36669": {"category_aro_accession": "3000530", "category_aro_cvterm_id": "36669", "category_aro_name": "rifabutin", "category_aro_description": "Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis.", "category_aro_class_name": "Antibiotic"}, "36673": {"category_aro_accession": "3000534", "category_aro_cvterm_id": "36673", "category_aro_name": "rifapentine", "category_aro_description": "Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy.", "category_aro_class_name": "Antibiotic"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.11689, "max_identities": 10, "bit_score": 22.7126, "cvterm_id": "41346", "query": "RLMTEHDLAMLYEWLNRSHIVE", "match": "R++TE D+A   E+L R H  E", "sequence_from_db": "RVLTEDDIAATIEYLVRLHAGE", "sequence_from_broadstreet": "MLEGRIVTVSSRTESPLAAPGVPGAPRRLSFARIREPLAVPGLLDIQTESFGWLIGAPDWCARAAARGTEPVAGLAEVLAEISPIEDFAGTMSLTLSDPRFEEVKASVEECKDKDLTYAAPWFVTAEFVNNNTGEIKSQTVFMGDFPMMTAHGTFVVNGTERVVVSQLVRSPGVYFDHAIDKGSEKDVHSARVIPSRGAWLEFDVDKRDTLGVRIDRKRRQPVTVLLKALGWSAERIAERFGFAPLIMASLAKDNVAGTDDALLEIHRKLRPGEPPTKESAQNLLANLFFTEKRYDLARVGRYKIDKKLGLRAPGAPRVLTEDDIAATIEYLVRLHAGERTMIAPGGVEVPVEVDDIDHFGNRRVRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQSLMNIRPVVAAMKEFFGTSQLSQFMDQRNPLASLTNKRRLSALGPGGLSRERAGLEVRDVHYSHYGRMCPIETPEGPNIGLMGYLSVYARVNPFGFVETPYRRVVDGRVTDEVDYLTADEEDRHVVAQANEPLDAEGRFLAARIPVRRKNSEVELVDSAAVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLIRSEAPIVGTGMELRAAVDAGDVVVNEKAGVVEEVSADYVTVMADDGTRKSYRMRKFNRSNQGTCSNQRPIVDEGQRVEAGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEQDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDDLPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPTEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWIGKAGWKVEGNPEWAKDLPEEMWEAPADSNIATPVFDGAREEELTGLLGSTLPNRDGERMVDDNGKAVLFDGRSGEPFPYPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGDNIPEPGVPESFKVLLKELQALCLNVEVLSAGAAVELAHGVDDDHERTAANLGINLSRAESITETELSG", "dna_sequence_from_broadstreet": "GTGCTGGAAGGACGCATCGTGACAGTCTCGAGTCGGACCGAGTCCCCGCTCGCCGCGCCCGGAGTCCCGGGTGCGCCCCGGCGGCTCTCGTTCGCCAGAATCCGCGAGCCCCTGGCGGTTCCGGGCCTGCTGGACATTCAGACCGAATCGTTCGGGTGGCTGATCGGCGCACCCGACTGGTGCGCCCGCGCGGCAGCCCGCGGGACGGAACCGGTCGCCGGGCTGGCCGAGGTGCTCGCCGAGATCAGCCCCATCGAGGACTTCGCGGGCACGATGTCGCTGACGTTGTCCGATCCGCGGTTCGAGGAGGTCAAGGCCTCCGTCGAGGAGTGCAAGGACAAGGATCTGACCTATGCCGCGCCGTGGTTCGTCACGGCGGAATTCGTGAACAACAACACCGGCGAGATCAAGAGCCAGACCGTTTTCATGGGTGATTTCCCCATGATGACCGCGCACGGGACATTCGTCGTCAACGGCACCGAACGGGTGGTCGTGTCGCAACTGGTGCGCTCGCCGGGCGTGTACTTCGACCACGCGATCGACAAGGGTTCGGAGAAGGACGTGCACAGCGCGCGGGTGATCCCGTCGCGCGGTGCCTGGCTGGAGTTCGACGTCGACAAGCGCGACACCCTGGGCGTGCGCATCGACCGCAAGCGCCGTCAGCCGGTAACGGTGCTGCTCAAGGCGCTGGGCTGGAGTGCGGAGCGAATCGCCGAGCGATTCGGGTTCGCCCCGCTGATCATGGCCTCGCTGGCCAAGGACAACGTGGCGGGCACCGACGACGCTTTGCTCGAGATCCATCGCAAGCTGCGTCCGGGCGAGCCGCCGACCAAGGAGTCGGCACAGAACCTGCTGGCAAATCTGTTCTTCACCGAGAAGCGCTACGACCTGGCGCGGGTGGGCCGTTACAAGATCGACAAGAAGCTCGGGCTGCGCGCTCCGGGGGCACCGCGGGTGCTCACCGAGGACGACATCGCGGCCACCATCGAGTACCTGGTGCGCCTGCACGCCGGGGAGAGGACGATGATCGCGCCCGGCGGGGTCGAGGTGCCGGTGGAGGTCGACGACATCGACCATTTCGGTAACCGCCGGGTGCGCACCGTGGGTGAGCTGATCCAGAACCAGATCCGCGTGGGTCTGTCCCGGATGGAACGGGTGGTGCGGGAGCGCATGACCACCCAGGACGTCGAGGCGATCACGCCGCAGTCGCTGATGAACATCCGCCCGGTGGTCGCGGCGATGAAGGAGTTCTTCGGCACCTCGCAGCTGTCGCAGTTCATGGACCAGCGCAACCCGCTGGCGAGCCTGACCAACAAGCGGCGGCTGTCCGCGCTCGGGCCGGGCGGGCTCTCGCGCGAACGGGCCGGCTTGGAGGTCCGCGACGTGCACTACAGCCACTACGGCCGGATGTGCCCGATCGAGACGCCGGAGGGGCCGAACATCGGCCTGATGGGGTACCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGTTTCGTCGAGACCCCCTACCGGCGGGTGGTGGACGGCCGGGTCACCGACGAGGTCGATTACCTCACCGCCGACGAGGAGGACCGGCACGTGGTGGCCCAGGCGAACGAACCGCTGGACGCCGAGGGCCGCTTCCTGGCCGCGCGAATCCCGGTGCGCCGGAAGAACTCCGAGGTGGAACTCGTCGATTCCGCCGCGGTGGATTACATGGATGTGTCGCCGCGGCAGATGGTGTCGGTGGCGACGGCGATGATTCCGTTCCTCGAGCATGATGATGCCAACCGTGCGCTGATGGGTGCGAATATGCAGCGTCAGGCGGTGCCGTTGATTCGGTCGGAGGCGCCGATCGTGGGTACCGGTATGGAGCTGCGTGCGGCGGTGGATGCCGGTGATGTGGTGGTGAACGAGAAGGCCGGTGTGGTCGAGGAGGTTTCGGCCGATTACGTCACGGTGATGGCCGATGACGGGACTCGTAAGTCGTATCGGATGCGGAAGTTCAACCGGTCGAATCAGGGGACGTGTTCGAATCAGCGGCCGATCGTGGACGAGGGTCAGCGGGTCGAGGCCGGGCAGGTGTTGGCTGATGGGCCGTGCACCGAGAACGGTGAGATGGCGCTGGGTAAGAACCTGTTGGTGGCGATCATGCCGTGGGAGGGGCACAACTACGAGGACGCGATCATCCTGTCGCAGCGGTTGGTGGAGCAGGATGTGTTGACCTCGATCCATATCGAGGAGCACGAGATCGATGCTCGTGACACCAAGCTCGGTGCCGAGGAGATCACTCGCGACATTCCGAATGTCTCCGATGAGGTGTTGGCGGATCTGGACGAGCGTGGCATCGTGCGGATCGGTGCGGAGGTGCGTGATGGTGACATCCTGGTCGGTAAGGTCACGCCCAAGGGTGAGACCGAGCTGACGCCGGAGGAGCGGTTGCTGCGGGCGATCTTCGGGGAGAAGGCGCGTGAGGTGCGTGATACCTCGTTGAAGGTGCCCCACGGTGAGTCGGGCAAGGTCATCGGGATCCGGGTGTTCTCTCGGGAGGACGATGACGATCTGCCGCCCGGTGTCAACGAGTTGGTGCGGGTGTATGTGGCGCAGAAGCGCAAGATCCAAGACGGTGACAAGCTGGCCGGTCGGCACGGGAACAAGGGTGTGATCGGCAAGATCCTGCCCACCGAGGACATGCCGTTCCTGCCCGATGGCACCCCGGTCGACATCATCCTCAACACCCACGGTGTGCCGCGGCGTATGAACATCGGCCAGATCCTGGAAACCCACCTCGGCTGGATCGGCAAAGCCGGCTGGAAGGTCGAGGGCAACCCCGAGTGGGCCAAGGATCTGCCGGAGGAGATGTGGGAGGCCCCCGCGGACTCCAACATCGCGACTCCGGTGTTCGACGGTGCCCGCGAGGAGGAGCTGACGGGTCTGCTGGGCTCGACGCTGCCCAACCGTGACGGTGAGCGGATGGTCGACGACAACGGCAAGGCCGTGCTGTTCGACGGTCGTTCCGGTGAGCCGTTCCCGTACCCGGTGGCGGTGGGCTACATGTACATCCTGAAGCTGCACCACCTGGTCGACGACAAGATCCACGCTCGCTCCACCGGCCCGTACTCGATGATCACCCAGCAGCCGCTCGGTGGTAAGGCCCAGTTCGGTGGCCAGCGCTTCGGTGAGATGGAGTGCTGGGCGATGCAGGCCTACGGCGCGGCCTACACCCTGCAGGAACTGCTCACGATCAAGTCCGACGACGTCGTCGGCCGCGTGAAGGTCTACGAGGCGATCGTCAAGGGCGACAACATCCCGGAACCCGGTGTGCCGGAATCGTTCAAGGTGTTGTTGAAGGAACTCCAGGCACTGTGCCTCAACGTCGAGGTGCTGTCCGCCGGTGCCGCGGTCGAACTGGCGCACGGGGTCGACGACGATCACGAGCGGACGGCCGCGAACCTCGGCATCAACCTGTCCCGCGCCGAATCCATCACGGAGACCGAGCTGTCCGGGTGA", "partial": "0", "query_start": 247, "query_end": 312, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 45.45}, "gnl|BL_ORD_ID|1219|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "otr(A)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1273", "ARO_accession": "3002891", "ARO_name": "otr(A)", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.44126, "max_identities": 7, "bit_score": 21.557, "cvterm_id": "36773", "query": "LMTEHDLAMLYEWLNRSHIV", "match": "L+ +HD A L  +L+  H++", "sequence_from_db": "LLADHDDAFLTAYLDEEHVL", "sequence_from_broadstreet": "MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV", "dna_sequence_from_broadstreet": "ATGAACAAGCTGAATCTGGGCATCCTGGCCCACGTTGACGCCGGCAAGACCAGCCTCACCGAGCGCCTGCTGCACCGCACCGGTGTGATCGACGAGGTCGGCAGCGTGGACGCCGGCACCACGACGACCGACTCGATGGAGCTGGAGCGGCAGCGCGGCATCACCATCCGGTCCGCCGTGGCCACGTTCGTCCTGGACGATCTCAAGGTCAACCTCATCGACACCCCGGGCCACTCCGACTTCATCTCCGAGGTCGAGCGGGCGCTCGGGGTGCTCGACGGCGCGGTCCTGGTGGTCTCGGCCGTCGAGGGCGTCCAGCCGCAGACCCGCATCCTGATGCGGACCCTGCGCAGGCTGGGCATTCCCACGCTGGTCTTCGTCAACAAGATCGACCGGGGCGGCGCGCGTCCCGACGGTGTGCTGCGGGAGATCCGCGACCGGCTCACCCCCGCCGCGGTGGCACTGTCCGCCGTGGCGGACGCCGGCACGCCGCGGGCCCGCGCGATCGCGCTCGGCCCGGACACCGACCCGGACTTCGCCGTCCGGGTCGGTGAGCTGCTGGCCGACCACGACGACGCGTTCCTCACCGCCTACCTGGACGAGGAACACGTACTGACCGAGAAGGAGTACGCGGAGGAACTGGCCGCGCAGACCGCGCGCGGTCTGGTGCACCCGGTGTACTTCGGGTCCGCGCTGACCGGCGAGGGCCTGGACCATCTGGTGCACGGCATCCGGGAGTTGCTGCCGTCCGTGCACGCGTCGCAGGACGCGCCGCTGCGGGCCACCGTGTTCAAGGTGGACCGTGGCGCGCGCGGCGAGGCCGTCGCGTACCTGCGGCTGGTCTCCGGCACGCTGGGCACCCGCGATTCGGTGACGCTGCACCGCGTCGACCACACCGGCCGGGTCACCGAGCACGCCGGACGCATCACCGCGCTGCGGGTCTTCGAGCACGGGTCGGCCACCAGCGAGACCCGGGCGACCGCCGGGGACATCGCGCAGGCGTGGGGCCTGAAGGACGTACGGGTCGGTGACCGGGCCGGGCACCTCGACGGTCCCCCGCCGCGCAACTTCTTCGCGCCGCCCAGCCTGGAGACCGTGATCAGGCCGGAGCGCCCGGAGGAAGCGGGACGGCTGCACGCCGCGCTGCGCATGCTGGACGAGCAGGACCCCTCGATCGACCTGCGGCAGGACGAGGAGAACGCGGCCGGCGCGGTGGTCCGCCTCTACGGGGAGGTGCAGAAGGAGATCCTCGGCAGCACGCTCGCGGAGTCCTTCGGCGTACGGGTGCGCTTCGACCCGACCCGTACGGTCTGCATCGAAAAGCCCGTGGGGACCGGCGAGGCGCTGATCGAGCTGGACACGCGGACGCACAACTACTTCTGGGGCGCACCGTGGGTCTGCGCGTCGGACCGGCCGAGCCCGGCGCGGGCGATCACGTTCCGTTTGGCGGTGGAACTGGGCTCGCTCCCCCTGGCCTTCCACAAGGCCATCGAGGAGACGGTGCACACCACCCTGCGGCACGGTCTGTACGGCTGGCAGGTCACCGACTGCGCCGTCACCCTGACCCGTACCGGCGTTCGCAGTCCGGTCAGCGCGGCCGACGACTTCCGCAAGGCCAACGCGCGCTTGGTCCTGATGGACGCGCTCGGCAGGGCCGGTACGGAGGTGCACGAGCCGGTCAGCTCCTTCGAACTGGAGGTGCCCGCCGCCCGGCTCAGCCCGGTACTTGCGAAACTCGCGGAACTGGGCGCGACGCCCGGTGTGCCCACGGCCGAGGGGGACGTCTTCCGCCTGGAGGGCACGATGCCGACCAGCCTCGTGCACGACTTCAACCAGCGGGTTCCCGGACTGACCCAGGGCGAGGGCGTGTTCCTGGCCGAGCACCGGGGCTACCGGCCCGCCGTCGGACAGCCGCCCGTGCGGCCGCGGCCCGAGGGGCCCAACCCGCTCAACCGCGACGAGTACATCCTGCACGTGCTCAAGCGCGTGTGA", "partial": "0", "query_start": 250, "query_end": 309, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 35.0}, "gnl|BL_ORD_ID|2106|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "salA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1100", "model_id": "2265", "ARO_accession": "3003749", "ARO_name": "salA", "ARO_category": {"41687": {"category_aro_accession": "3004469", "category_aro_cvterm_id": "41687", "category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins.", "category_aro_class_name": "AMR Gene Family"}, "37716": {"category_aro_accession": "3001317", "category_aro_cvterm_id": "37716", "category_aro_name": "pleuromutilin", "category_aro_description": "Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36218": {"category_aro_accession": "3000079", "category_aro_cvterm_id": "36218", "category_aro_name": "oxazolidinone antibiotic", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37014": {"category_aro_accession": "3000670", "category_aro_cvterm_id": "37014", "category_aro_name": "pleuromutilin antibiotic", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.63586, "max_identities": 8, "bit_score": 21.557, "cvterm_id": "40406", "query": "MTEHDLAMLYEWLNRSHIVE", "match": "M E DL   Y+W    +I+E", "sequence_from_db": "MMEQDLTPYYDWTVMDYIIE", "sequence_from_broadstreet": "MLFLFEEKALEVEHKVLIPELTFSIEDHEHLAIVGVNGVGKSTLLKVIHQDQSVDSAMMEQDLTPYYDWTVMDYIIESYPEIAKIRLQLNHTDMINKYIELDGYIIEGEIVTEAKKLGIKEEQLEQKISTLSGGEQTKVSFLKVKMSKASLLLIDEPTNHMDLEMKEWLTKAFKQEQRAILFVSHDRTFLNETPDAILELSLDGAKKYIGKYDKYKQQKDIEHETLKLQYEKQQKEQAAIEETIKKYKAWYQKAEQSASVRSPYQQKQLSKLAKRFKSKEQQLNRKLDQEHIPNPHKKEKTFSIQHHNFKSHYLVQFNHVSFAYDNRKIFDDVSFYIKRNQNVIVEGRNGTGKSTLIKLILGELEPTKGDITVHPELEIGYFSQDFENLNMHHTVLDEILEIPEMKEADARTILASFYFDKDRINDVVETLSMGEKCRLQFVKLYFSNPHIMILDEPTNYFDIGMQENIIQLIQSFQGSVLIVSHDNYFKSQIKDQTWTIKNHQMTHENVQVKDPINTESMKHHLKELEQYTDERNRETEF", "dna_sequence_from_broadstreet": "ATGCTATTTTTATTTGAAGAAAAAGCATTAGAAGTTGAACATAAAGTATTAATACCCGAGTTGACTTTTTCAATAGAGGACCATGAACATTTAGCAATCGTTGGTGTTAATGGTGTTGGAAAATCAACATTATTAAAAGTCATTCATCAAGATCAATCAGTTGATTCAGCGATGATGGAACAAGATTTAACACCTTATTATGATTGGACTGTTATGGATTATATAATTGAATCATATCCTGAAATCGCAAAGATTAGATTGCAACTTAATCATACAGATATGATTAATAAATATATTGAATTAGATGGATACATTATAGAAGGTGAAATCGTAACAGAAGCAAAAAAGCTCGGAATAAAAGAGGAACAACTAGAACAGAAAATTTCTACTTTAAGTGGTGGAGAACAAACAAAAGTATCATTTTTAAAAGTGAAAATGTCTAAAGCATCATTACTATTAATCGATGAACCAACAAACCACATGGATTTAGAAATGAAGGAATGGTTGACGAAAGCTTTTAAACAAGAACAACGTGCTATATTATTTGTATCTCATGACCGAACATTTTTAAATGAAACGCCAGATGCTATATTAGAATTGAGTCTTGATGGGGCTAAGAAGTATATCGGTAAATACGATAAATACAAACAACAAAAAGATATAGAGCATGAAACATTAAAGCTACAGTATGAAAAACAACAAAAAGAACAAGCGGCCATTGAAGAAACGATTAAAAAATATAAAGCATGGTATCAAAAAGCAGAACAAAGTGCTTCTGTGAGAAGCCCATATCAACAAAAACAATTAAGTAAGTTAGCGAAACGGTTTAAATCAAAAGAACAACAATTAAATCGTAAACTTGATCAAGAGCATATCCCAAATCCACATAAAAAAGAGAAAACTTTCTCAATACAACATCATAATTTTAAATCACATTATTTAGTTCAATTTAATCATGTTTCGTTTGCTTATGATAACCGGAAAATATTCGATGATGTATCATTCTATATTAAGCGAAATCAAAATGTTATTGTTGAAGGCAGAAATGGTACAGGTAAATCAACTTTAATCAAATTGATACTCGGTGAACTCGAGCCAACTAAAGGTGATATAACTGTTCATCCAGAATTAGAAATTGGATATTTCTCTCAAGATTTTGAGAATTTAAATATGCATCATACTGTCTTAGATGAAATATTAGAAATTCCTGAAATGAAAGAAGCAGATGCAAGAACCATATTAGCAAGCTTTTATTTTGATAAAGATAGGATAAATGATGTTGTTGAAACACTATCGATGGGTGAAAAATGTAGGTTACAATTTGTAAAATTATATTTTTCAAATCCTCATATTATGATATTAGATGAGCCAACAAACTATTTCGATATTGGCATGCAAGAAAATATCATTCAATTAATACAATCATTTCAAGGTTCGGTCCTTATTGTATCTCATGATAATTATTTTAAATCACAAATTAAAGATCAGACTTGGACTATAAAAAATCATCAAATGACGCATGAAAATGTTCAAGTCAAAGATCCTATTAATACAGAATCTATGAAACATCATTTAAAAGAATTAGAACAATATACAGATGAAAGAAATCGTGAAACAGAGTTCTAG", "partial": "0", "query_start": 253, "query_end": 312, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 40.0}, "gnl|BL_ORD_ID|2095|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.48609, "max_identities": 9, "bit_score": 20.4014, "cvterm_id": "42594", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 238, "query_end": 291, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2094|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.48609, "max_identities": 9, "bit_score": 20.4014, "cvterm_id": "40382", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 238, "query_end": 291, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}}, "NODE_1_length_803036_cov_42.265_543 # 550760 # 553018 # -1 # ID=1_543;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.593": {"gnl|BL_ORD_ID|2055|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "I", "position": 80}, "query_snp": {"original": "S", "change": "I", "position": 80}, "orf_strand": "-", "orf_start": 550760, "orf_end": 553018, "orf_from": "NODE_1_length_803036_cov_42.265_543 ", "model_name": "Escherichia coli parC conferring resistance to fluoroquinolone", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "1450", "pass_evalue": "n/a", "pass_bitscore": 1400, "ARO_accession": "3003308", "ARO_name": "Escherichia coli parC conferring resistance to fluoroquinolone", "ARO_category": {"36913": {"category_aro_accession": "3000619", "category_aro_cvterm_id": "36913", "category_aro_name": "fluoroquinolone resistant parC", "category_aro_description": "ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations.", "category_aro_class_name": "AMR Gene Family"}, "35942": {"category_aro_accession": "0000023", "category_aro_cvterm_id": "35942", "category_aro_name": "enoxacin", "category_aro_description": "Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35988": {"category_aro_accession": "0000071", "category_aro_cvterm_id": "35988", "category_aro_name": "levofloxacin", "category_aro_description": "Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication.", "category_aro_class_name": "Antibiotic"}, "35991": {"category_aro_accession": "0000074", "category_aro_cvterm_id": "35991", "category_aro_name": "moxifloxacin", "category_aro_description": "Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases.", "category_aro_class_name": "Antibiotic"}, "37003": {"category_aro_accession": "3000659", "category_aro_cvterm_id": "37003", "category_aro_name": "gatifloxacin", "category_aro_description": "Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "37004": {"category_aro_accession": "3000660", "category_aro_cvterm_id": "37004", "category_aro_name": "lomefloxacin", "category_aro_description": "Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "37008": {"category_aro_accession": "3000664", "category_aro_cvterm_id": "37008", "category_aro_name": "trovafloxacin", "category_aro_description": "Trovafloxacin is a trifluoroquinalone with a broad spectrum of activity that acts by inhibiting the uncoiling of supercoiled DNA. While potent against many Gram-positive and Gram-negative bacteria, it is less active against pseudomonads and Cl. difficile. It is usually taken as the prodrug trovafloxacin mesylate or alatrofloxacin mesylate for oral or intravenous administration, respectively.", "category_aro_class_name": "Antibiotic"}, "37009": {"category_aro_accession": "3000665", "category_aro_cvterm_id": "37009", "category_aro_name": "grepafloxacin", "category_aro_description": "Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity.", "category_aro_class_name": "Antibiotic"}, "37010": {"category_aro_accession": "3000666", "category_aro_cvterm_id": "37010", "category_aro_name": "sparfloxacin", "category_aro_description": "Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes.", "category_aro_class_name": "Antibiotic"}, "37142": {"category_aro_accession": "3000762", "category_aro_cvterm_id": "37142", "category_aro_name": "pefloxacin", "category_aro_description": "Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 710, "bit_score": 1470.29, "cvterm_id": "36849", "query": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDIACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSPLHEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAQGLSYKAGDSWKASAKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNKIISIPAAEAAAGQDGLAHLFVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGSLMRGLQKIDRVEIDSPRRAAAGDSEE", "match": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGD ACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKY+ELLLSELGQGT DWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVA+AAI LI+QPKTTLD+LLDIVQGPD+PTEAEIITSRAEIRKIY+NGRGSVRMRAVW KEDGAVVISALPHQVSGA+VLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDM+QVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLN+RLEKVLKRLHILEGLLVAFLNIDEVIEIIR EDEPKPALMSRFG++ETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQ ILASERKMNNLLKKELQADA A+GDDRRSPL EREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDA GL+YKAGDS+KA+ KGKSNQPVVF+D+TGRSYAIDPITLPSARGQGEPLTGKLTLPPGATV+HMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLP+NAHVMPP+VIED SDMLLAIT AGRMLMFPVSDLPQLSKGKGNKII+IP+AEAA G+DGLA L+VLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRG+LMRGLQ+IDRVEIDSPRRA++GDSEE", "sequence_from_db": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE", "sequence_from_broadstreet": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE", "dna_sequence_from_broadstreet": "ATGAGCGATATGGCAGAGCGCCTTGCGCTACATGAATTTACGGAAAACGCCTACTTAAACTACTCCATGTACGTGATCATGGACCGTGCGTTGCCGTTTATTGGTGATGGTCTGAAACCTGTTCAGCGCCGCATTGTGTATGCGATGTCTGAACTGGGCCTGAATGCCAGCGCCAAATTTAAAAAATCGGCCCGTACCGTCGGTGACGTACTGGGTAAATACCATCCGCACGGCGATAGCGCCTGTTATGAAGCGATGGTCCTGATGGCGCAACCGTTCTCTTACCGTTATCCGCTGGTTGATGGTCAGGGGAACTGGGGCGCGCCGGACGATCCGAAATCGTTCGCGGCAATGCGTTACACCGAATCCCGGTTGTCGAAATATTCCGAGCTGCTATTGAGCGAGCTGGGGCAGGGGACGGCTGACTGGGTGCCAAACTTCGACGGCACTTTGCAGGAGCCGAAAATGCTACCTGCCCGTCTGCCAAACATTTTGCTTAACGGCACCACCGGTATTGCCGTCGGCATGGCGACCGATATTCCACCGCATAACCTGCGTGAAGTGGCTCAGGCGGCAATCGCATTAATCGACCAGCCGAAAACCACGCTCGATCAGCTGCTGGATATCGTGCAGGGGCCGGATTATCCGACTGAAGCGGAAATTATCACTTCGCGCGCCGAGATCCGTAAAATCTACGAGAACGGACGTGGTTCAGTGCGTATGCGCGCGGTGTGGAAGAAAGAAGATGGCGCGGTGGTTATCAGCGCATTGCCGCATCAGGTTTCAGGTGCGCGCGTACTGGAGCAAATTGCTGCGCAAATGCGCAACAAAAAGCTGCCGATGGTTGACGATCTGCGCGATGAATCTGACCACGAGAACCCGACCCGCCTGGTGATTGTGCCGCGTTCCAACCGCGTGGATATGGATCAGGTGATGAACCACCTCTTCGCTACCACCGATCTGGAAAAGAGCTATCGTATTAACCTTAATATGATCGGTCTGGATGGTCGTCCGGCGGTGAAAAACCTGCTGGAAATCCTCTCCGAATGGCTGGTGTTCCGCCGCGATACCGTGCGCCGCCGACTGAACTATCGTCTGGAGAAAGTCCTCAAGCGCCTGCATATCCTCGAAGGTTTGCTGGTGGCGTTTCTCAATATCGACGAAGTGATTGAGATCATTCGTAATGAAGATGAACCGAAACCGGCGCTGATGTCGCGGTTTGGCCTTACGGAAACCCAGGCGGAAGCGATCCTCGAACTGAAACTGCGTCATCTTGCCAAACTGGAAGAGATGAAGATTCGCGGTGAGCAGAGTGAACTGGAAAAAGAGCGCGACCAGTTGCAGGGCATTTTGGCTTCCGAGCGTAAAATGAATAACCTGCTGAAGAAAGAACTGCAGGCAGACGCGCAAGCCTACGGTGACGATCGTCGTTCGCCGTTGCAGGAACGCGAAGAAGCGAAAGCGATGAGCGAGCACGACATGCTGCCGTCTGAACCTGTCACCATTGTGCTGTCGCAGATGGGCTGGGTACGCAGCGCTAAAGGCCATGATATCGACGCGCCGGGCCTGAATTATAAAGCGGGTGATAGCTTCAAAGCGGCGGTGAAAGGTAAGAGCAACCAACCGGTAGTGTTTGTTGATTCCACCGGTCGTAGCTATGCCATTGACCCGATTACGCTGCCGTCGGCGCGTGGTCAGGGCGAGCCGCTCACCGGCAAATTAACGTTGCCGCCTGGGGCGACCGTTGACCATATGCTGATGGAAAGCGACGATCAGAAACTGCTGATGGCTTCCGATGCGGGTTACGGTTTCGTCTGCACCTTTAACGATCTGGTGGCGCGTAACCGTGCAGGTAAGGCTTTGATCACCTTACCGGAAAATGCCCATGTTATGCCGCCGGTGGTGATTGAAGATGCTTCCGATATGCTGCTGGCAATCACTCAGGCAGGCCGTATGTTGATGTTCCCGGTAAGTGATCTGCCGCAGCTGTCGAAGGGCAAAGGCAACAAGATTATCAACATTCCATCGGCAGAAGCCGCGCGTGGAGAAGATGGTCTGGCGCAATTGTACGTTCTGCCGCCGCAAAGCACGCTGACCATTCATGTTGGGAAACGCAAAATTAAACTGCGCCCGGAAGAGTTACAGAAAGTCACTGGCGAACGTGGACGCCGCGGTACGTTGATGCGCGGTTTGCAGCGTATCGATCGTGTTGAGATCGACTCTCCTCGCCGTGCCAGCAGCGGTGATAGCGAAGAGTAA", "partial": "0", "query_start": 550760, "query_end": 553015, "orf_dna_sequence": "ATGAGCGATATGGCAGAGCGCCTTGCGCTGCATGAATTTACGGAAAATGCTTACCTGAACTACTCCATGTACGTGATCATGGACAGGGCATTACCGTTTATTGGCGATGGCTTAAAACCGGTCCAGCGTCGCATCGTCTATGCGATGTCCGAGCTGGGGCTGAACGCCAGCGCGAAATTCAAAAAGTCCGCCCGCACCGTCGGCGACGTGTTGGGTAAATATCACCCGCACGGCGACATCGCCTGCTATGAAGCGATGGTGCTGATGGCGCAGCCGTTCTCTTACCGCTATCCGCTGGTGGATGGTCAGGGAAACTGGGGGGCGCCGGACGATCCCAAATCTTTCGCCGCCATGCGTTACACCGAATCCCGCCTGTCGAAGTATGCCGAGCTGCTGCTCAGCGAGCTGGGGCAGGGGACGGTCGACTGGGTGCCAAACTTTGACGGCACGCTGCAGGAGCCGAAAATGCTGCCAGCGCGTCTGCCGAACATCCTGCTGAACGGCACCACCGGCATCGCGGTAGGCATGGCGACCGATATTCCTCCGCACAACCTGCGGGAAGTGGCCAAAGCGGCGATTACGCTGATTGAGCAGCCGAAAACCACCCTCGACGAACTGCTGGATATCGTACAGGGGCCGGATTTCCCGACCGAGGCGGAGATCATCACCTCGCGGGCGGAAATTCGCAAAATCTACCAGAACGGGCGCGGCTCAGTGCGCATGCGTGCGGTGTGGAGTAAAGAGGACGGCGCGGTGGTGATCAGTGCGCTGCCGCATCAGGTCTCCGGCGCCAAAGTGCTGGAGCAGATTGCGGCGCAGATGCGCAATAAAAAGCTGCCGATGGTTGACGATCTGCGCGACGAATCGGACCACGAAAACCCGACCCGTCTGGTGATTGTCCCGCGCTCCAACCGGGTGGATATGGAACAGGTGATGAACCACCTGTTCGCCACCACCGATCTGGAGAAGAGCTACCGCATCAACCTCAATATGATCGGCCTTGACGGCCGCCCGGCGGTGAAAAACCTGCTGGAGATCCTCAGCGAGTGGCTGGTGTTCCGTCGCGATACCGTGCGTCGCCGTCTAAACCATCGGTTAGAGAAAGTGCTGAAGCGCCTGCATATCCTCGAAGGTTTGCTGGTGGCGTTTCTTAATATCGATGAAGTGATTGAGATCATCCGCACTGAAGATGAACCGAAGCCGGCCCTGATGTCGCGCTTTGGCATCAGCGAAACCCAGGCGGAAGCGATTCTGGAATTAAAACTGCGCCACCTCGCCAAACTGGAAGAGATGAAGATCCGCGGCGAGCAGAGCGAGCTGGAAAAAGAGCGCGACCAGCTGCAGGCGATTCTGGCGTCTGAACGTAAGATGAACAACCTGCTGAAAAAAGAGCTGCAGGCCGATGCCGATGCCTTCGGCGACGACCGTCGCTCGCCGCTTCACGAGCGTGAAGAAGCGAAAGCGATGAGCGAGCATGACATGCTGCCGTCTGAGCCGGTGACTATCGTTCTGTCGCAGATGGGCTGGGTGCGCAGCGCCAAAGGACACGACATTGACGCCCAGGGCTTGAGCTATAAGGCGGGCGACAGCTGGAAAGCCTCGGCGAAGGGCAAGAGCAACCAGCCGGTGGTGTTTATCGATACCACCGGACGCAGCTATGCCATCGATCCGATTACTCTGCCTTCCGCGCGTGGCCAGGGTGAACCGCTTACCGGCAAACTGACCCTGCCGCCGGGCGCGACCGTGGAGCATATGCTAATGGAAAGCGACGATCAGAAACTGCTGATGGCTTCCGACGCGGGCTACGGTTTCGTCTGTACCTTCAACGATCTGGTGGCGCGCAACCGTGCCGGTAAAGCGCTAATCACCCTGCCTGACAACGCGCACGTGATGCCGCCGCTGGTGATTGAGGATGAGTCCGATATGCTGCTGGCCATCACCGCCGCCGGGCGGATGCTGATGTTCCCGGTCAGCGATCTGCCGCAGCTGTCGAAAGGCAAGGGCAACAAAATTATCAGCATTCCGGCGGCGGAAGCCGCAGCCGGCCAGGACGGTCTGGCACATCTGTTTGTTCTGCCGCCGCAGAGTACGCTGACCATTCACGTCGGCAAACGGAAGATCAAACTGCGTCCGGAAGAGCTGCAAAAAGTCACCGGCGAGCGCGGCCGCCGCGGTTCGCTGATGCGCGGGCTGCAGAAAATTGACCGCGTGGAAATTGACTCGCCGCGTCGTGCCGCGGCAGGCGATAGCGAAGAGTAA", "orf_prot_sequence": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDIACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSPLHEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAQGLSYKAGDSWKASAKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNKIISIPAAEAAAGQDGLAHLFVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGSLMRGLQKIDRVEIDSPRRAAAGDSEE", "perc_identity": 94.41}}, "NODE_3_length_454317_cov_40.2449_130 # 161019 # 163652 # -1 # ID=3_130;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.584": {"gnl|BL_ORD_ID|2531|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Salmonella enterica gyrA with mutation conferring resistance to triclosan", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2850", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3004334", "ARO_name": "Salmonella enterica gyrA with mutation conferring resistance to triclosan", "ARO_category": {"41501": {"category_aro_accession": "3004333", "category_aro_cvterm_id": "41501", "category_aro_name": "triclosan resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 834, "bit_score": 1702.95, "cvterm_id": "35734", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADT", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+D+EDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVE DAK+GRETIIVHEIPYQVNKARLIEKIAELVK+KRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDII+AFVRHRREVVTRRTIFELRKARDRAHILEALA+ALANIDPIIELIRRAPTPAEAK AL+++ WDLGNVAAMLERAGDDAARPEWLEPEFGVRDG+YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREE+ELIRDQFGDERRTEITANSADINIEDLI+QEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEA+ERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLN+GDELIGVDLTSG DEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLA +D VVSLIIPRGEGAILTVTQNGYGKRTAA EYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSE+S+VGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGS AEGD+DIAPEA++", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAES", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGCACCGGTCGTGGCAAAGTGTACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGATATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGTGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCCAACATCGACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCGGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGCTGGTGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTGACTGAACAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGAGCAGATTGCTGAATTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACAGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAGTATGAAGAAGGCGTCAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGTGTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAACGGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAACGGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGTGTGTCCGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGATGAAAACGTGGTGGGTCTGCAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA", "partial": "0", "query_start": 161019, "query_end": 163622, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 96.08}, "gnl|BL_ORD_ID|2220|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2403", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3003926", "ARO_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "ARO_category": {"39876": {"category_aro_accession": "3003292", "category_aro_cvterm_id": "39876", "category_aro_name": "fluoroquinolone resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 834, "bit_score": 1702.95, "cvterm_id": "35734", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADT", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+D+EDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVE DAK+GRETIIVHEIPYQVNKARLIEKIAELVK+KRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDII+AFVRHRREVVTRRTIFELRKARDRAHILEALA+ALANIDPIIELIRRAPTPAEAK AL+++ WDLGNVAAMLERAGDDAARPEWLEPEFGVRDG+YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREE+ELIRDQFGDERRTEITANSADINIEDLI+QEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEA+ERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLN+GDELIGVDLTSG DEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLA +D VVSLIIPRGEGAILTVTQNGYGKRTAA EYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSE+S+VGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGS AEGD+DIAPEA++", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAES", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGCACCGGTCGTGGCAAAGTGTACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGATATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGTGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCCAACATCGACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCGGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGCTGGTGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTGACTGAACAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGAGCAGATTGCTGAATTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACAGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAGTATGAAGAAGGCGTCAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGTGTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAACGGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAACGGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGTGTGTCCGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGATGAAAACGTGGTGGGTCTGCAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA", "partial": "0", "query_start": 161019, "query_end": 163622, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 96.08}, "gnl|BL_ORD_ID|2532|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Escherichia coli gyrA with mutation conferring resistance to triclosan", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2851", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3004335", "ARO_name": "Escherichia coli gyrA with mutation conferring resistance to triclosan", "ARO_category": {"41501": {"category_aro_accession": "3004333", "category_aro_cvterm_id": "41501", "category_aro_name": "triclosan resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 806, "bit_score": 1639.01, "cvterm_id": "36849", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAED", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+DDEDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAK+GRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIR APTPAEAKTALVA  W LGNVAAMLERAGDDAARPEWLEPEFGVRDG YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELL+QIAELL ILGSADRLMEVIREELEL+R+QFGD+RRTEITANSADIN+EDLI QEDVVVTLSHQGYVKYQPL++YEAQRRGGKGKSAARIKEEDFIDRLLVANTHD ILCFSSRGR+Y MKVYQLPEA+RGARGRPIVNLLPLE DERITAILPV E+EEGV VFMATA+GTVKKT LTEF+R R+AG +A+ L +GDELIGVDLTSG+DEVMLFSA GKVVRFKE +VRAMG   TGVRGI+L E D VVSLI+PRG+GAILT TQNGYGKRTA AEYPTKSRAT+GVISIKVTERNG VVGAVQVDDCDQIMMITDAGTLVRTRVSE+SIVGRNTQGVILIRTAEDENVVGLQRVAEPVD+E+LD IDGSAAEGDD+IAPE D DD+  E+", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCAGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTACTAGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCATGGTGACTCGGCGGTCTATGACACGATCGTCCGCATGGCGCAGCCATTCTCGCTGCGTTATATGCTGGTAGACGGTCAGGGTAACTTCGGTTCTATCGACGGCGACTCTGCGGCGGCAATGCGTTATACGGAAATCCGTCTGGCGAAAATTGCCCATGAACTGATGGCCGATCTCGAAAAAGAGACGGTCGATTTCGTTGATAACTATGACGGCACGGAAAAAATTCCGGACGTCATGCCAACCAAAATTCCTAACCTGCTGGTGAACGGTTCTTCCGGTATCGCCGTAGGTATGGCAACCAACATCCCGCCGCACAACCTGACGGAAGTCATCAACGGTTGTCTGGCGTATATTGATGATGAAGACATCAGCATTGAAGGGCTGATGGAACACATCCCGGGGCCGGACTTCCCGACGGCGGCAATCATTAACGGTCGTCGCGGTATTGAAGAAGCTTACCGTACCGGTCGCGGCAAGGTGTATATCCGCGCTCGCGCAGAAGTGGAAGTTGACGCCAAAACCGGTCGTGAAACCATTATCGTCCACGAAATTCCGTATCAGGTAAACAAAGCGCGCCTGATCGAGAAGATTGCGGAACTGGTAAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGACAAAGACGGTATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTCGGTGAAGTTGTGCTCAACAACCTCTACTCCCAGACCCAGTTGCAGGTTTCTTTCGGTATCAACATGGTGGCATTGCACCATGGTCAGCCGAAGATCATGAACCTGAAAGACATCATCGCGGCGTTTGTTCGTCACCGCCGTGAAGTGGTGACCCGTCGTACTATTTTCGAACTGCGTAAAGCTCGCGATCGTGCTCATATCCTTGAAGCATTAGCCGTGGCGCTGGCGAACATCGACCCGATCATCGAACTGATCCGTCATGCGCCGACGCCTGCAGAAGCGAAAACTGCGCTGGTTGCTAATCCGTGGCAGCTGGGCAACGTTGCCGCGATGCTCGAACGTGCTGGCGACGATGCTGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTGCGTGATGGTCTGTACTACCTGACCGAACAGCAAGCTCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGTCTTGAGCACGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGATCAGATCGCGGAACTGTTGCGTATTCTTGGTAGCGCCGATCGTCTGATGGAAGTGATCCGTGAAGAGCTGGAGCTGGTTCGTGAACAGTTCGGTGACAAACGTCGTACTGAAATCACCGCCAACAGCGCAGACATCAACCTGGAAGATCTGATCACCCAGGAAGATGTGGTCGTGACGCTCTCTCACCAGGGCTACGTTAAGTATCAGCCGCTTTCTGAATACGAAGCGCAGCGTCGTGGCGGGAAAGGTAAATCTGCCGCACGTATTAAAGAAGAAGACTTTATCGACCGACTGCTGGTGGCGAACACTCACGACCATATTCTGTGCTTCTCCAGCCGTGGTCGCGTCTATTCGATGAAAGTTTATCAGTTGCCGGAAGCCACTCGTGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAGCAGGACGAACGTATCACTGCGATCCTGCCAGTGACCGAGTTTGAAGAAGGCGTGAAAGTCTTCATGGCGACCGCTAACGGTACCGTGAAGAAAACTGTCCTCACCGAGTTCAACCGTCTGCGTACCGCCGGTAAAGTGGCGATCAAACTGGTTGACGGCGATGAGCTGATCGGCGTTGACCTGACCAGCGGCGAAGACGAAGTAATGCTGTTCTCCGCTGAAGGTAAAGTGGTGCGCTTTAAAGAGTCTTCTGTCCGTGCGATGGGCTGCAACACCACCGGTGTTCGCGGTATTCGCTTAGGTGAAGGCGATAAAGTCGTCTCTCTGATCGTGCCTCGTGGCGATGGCGCAATCCTCACCGCAACGCAAAACGGTTACGGTAAACGTACCGCAGTGGCGGAATACCCAACCAAGTCGCGTGCGACGAAAGGGGTTATCTCCATCAAGGTTACCGAACGTAACGGTTTAGTTGTTGGCGCGGTACAGGTAGATGACTGCGACCAGATCATGATGATCACCGATGCCGGTACGCTGGTACGTACTCGCGTTTCGGAAATCAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGTACTGCGGAAGATGAAAACGTAGTGGGTCTGCAACGTGTTGCTGAACCGGTTGACGAGGAAGATCTGGATACCATCGACGGCAGTGCCGCGGAAGGGGACGATGAAATCGCTCCGGAAGTGGACGTTGACGACGAGCCAGAAGAAGAATAA", "partial": "0", "query_start": 161019, "query_end": 163643, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 92.11}}, "NODE_4_length_367278_cov_42.3139_202 # 219948 # 221714 # 1 # ID=4_202;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.564": {"gnl|BL_ORD_ID|2567|hsp_num:0": {"type_match": "Strict", "snp": {"original": "D", "change": "N", "position": 350}, "query_snp": {"original": "D", "change": "N", "position": 327}, "orf_strand": "+", "orf_start": 219948, "orf_end": 221714, "orf_from": "NODE_4_length_367278_cov_42.3139_202 ", "model_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2886", "pass_evalue": "n/a", "pass_bitscore": 500, "ARO_accession": "3004446", "ARO_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "ARO_category": {"40661": {"category_aro_accession": "3003938", "category_aro_cvterm_id": "40661", "category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 297, "bit_score": 593.964, "cvterm_id": "41640", "query": "APKTPKAKRQEE--QANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALA", "match": "AP+T K  + ++  +  F+  R+ L    ILL L  L+ R A++Q I+ D L  + D RSLR  EV + RG I DR+G+ L+VSVP+ AI ADPK +     +    R  ALA+ L M  + L  +I  N +  ++YLARQV    A+YI++LK+ GI L  E RR+YP  E  AH++G+T++D  GIEG+EKSF+  L G+ G R VRKD+ G ++  IS      A ++ LSIDE+LQ++VYRE+  AV+ N AESG+AVLVDV TGEVLAMA +PSYNPNN  G   + MRNRAITD FEPGSTVKP VV+T LQRG+V  + +++T  ++++G EI DVA  ++ TL  +L  SSN GVS+LAL MP SAL++TY   GL K T+LGL+GE+ G L   ++RW+DIERAT ++GYG+  TPLQ+AR YAT+GS+G+YRPLSITKVDPPV G+RVF E + + +V ++E VA+      +A ++GYR+ +KTGTA+K+  +G Y+NKY+A+TAG+AP S PR+ALVV+INDP+AG+YYGGAVSAPVF  IMG  LR   I  DA A", "sequence_from_db": "APETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNK---RAMVEGYRVGVKTGTARKI-ENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEA", "sequence_from_broadstreet": "MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN", "dna_sequence_from_broadstreet": "ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAAGCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTGGCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGTTCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCCGATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAGCCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCACGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCGTTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGAAAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACATATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGAGATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAGCTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACCGATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGAAATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACGAGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTATCAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACGCTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATGCAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTCTCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTACCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGGGTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGTGCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGCTGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA", "partial": "0", "query_start": 219957, "query_end": 221654, "orf_dna_sequence": "ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGCGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAACCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGGTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAAAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTGCGTAAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTGCAGGCGCTGGTCTATCGCGAGCTAAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTAGATGTTAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACCGACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGTGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAAGTTGATCCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGCGGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA", "orf_prot_sequence": "MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS", "perc_identity": 52.2}, "gnl|BL_ORD_ID|2567|hsp_num:1": {"type_match": "Strict", "snp": {"original": "S", "change": "N", "position": 357}, "query_snp": {"original": "S", "change": "N", "position": 334}, "orf_strand": "+", "orf_start": 219948, "orf_end": 221714, "orf_from": "NODE_4_length_367278_cov_42.3139_202 ", "model_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2886", "pass_evalue": "n/a", "pass_bitscore": 500, "ARO_accession": "3004446", "ARO_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "ARO_category": {"40661": {"category_aro_accession": "3003938", "category_aro_cvterm_id": "40661", "category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 297, "bit_score": 593.964, "cvterm_id": "41640", "query": "APKTPKAKRQEE--QANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALA", "match": "AP+T K  + ++  +  F+  R+ L    ILL L  L+ R A++Q I+ D L  + D RSLR  EV + RG I DR+G+ L+VSVP+ AI ADPK +     +    R  ALA+ L M  + L  +I  N +  ++YLARQV    A+YI++LK+ GI L  E RR+YP  E  AH++G+T++D  GIEG+EKSF+  L G+ G R VRKD+ G ++  IS      A ++ LSIDE+LQ++VYRE+  AV+ N AESG+AVLVDV TGEVLAMA +PSYNPNN  G   + MRNRAITD FEPGSTVKP VV+T LQRG+V  + +++T  ++++G EI DVA  ++ TL  +L  SSN GVS+LAL MP SAL++TY   GL K T+LGL+GE+ G L   ++RW+DIERAT ++GYG+  TPLQ+AR YAT+GS+G+YRPLSITKVDPPV G+RVF E + + +V ++E VA+      +A ++GYR+ +KTGTA+K+  +G Y+NKY+A+TAG+AP S PR+ALVV+INDP+AG+YYGGAVSAPVF  IMG  LR   I  DA A", "sequence_from_db": "APETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNK---RAMVEGYRVGVKTGTARKI-ENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEA", "sequence_from_broadstreet": "MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN", "dna_sequence_from_broadstreet": "ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAAGCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTGGCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGTTCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCCGATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAGCCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCACGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCGTTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGAAAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACATATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGAGATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAGCTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACCGATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGAAATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACGAGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTATCAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACGCTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATGCAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTCTCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTACCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGGGTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGTGCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGCTGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA", "partial": "0", "query_start": 219957, "query_end": 221654, "orf_dna_sequence": "ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGCGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAACCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGGTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAAAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTGCGTAAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTGCAGGCGCTGGTCTATCGCGAGCTAAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTAGATGTTAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACCGACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGTGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAAGTTGATCCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGCGGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA", "orf_prot_sequence": "MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS", "perc_identity": 52.2}}, "NODE_15_length_100593_cov_44.6763_85 # 89219 # 90610 # 1 # ID=15_85;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.585": {"gnl|BL_ORD_ID|2191|hsp_num:0": {"type_match": "Strict", "snp": {"original": "E", "change": "Q", "position": 350}, "query_snp": {"original": "E", "change": "Q", "position": 350}, "orf_strand": "+", "orf_start": 89219, "orf_end": 90610, "orf_from": "NODE_15_length_100593_cov_44.6763_85 ", "model_name": "Escherichia coli UhpT with mutation conferring resistance to fosfomycin", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2373", "pass_evalue": "n/a", "pass_bitscore": 850, "ARO_accession": "3003890", "ARO_name": "Escherichia coli UhpT with mutation conferring resistance to fosfomycin", "ARO_category": {"41412": {"category_aro_accession": "3004248", "category_aro_cvterm_id": "41412", "category_aro_name": "UhpT", "category_aro_description": "UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 440, "bit_score": 864.374, "cvterm_id": "40589", "query": "MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA", "match": "MLAFLNQVRKPTLDLPL+VRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMG+GS SLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLG AEELFGE ISEEDKETE   MTKWQIFVEYVLKNKVIWLLCF+NIFLYVVRIGIDQWSTVYAFQELKLSK VAIQGFTLFE GALVGTLLWGWLSDLANGRR LVACIALALIIATLGVYQHASN+Y+YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALD AA+GCICLMAIVA+ EERKIRREKK + L  A", "sequence_from_db": "MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA", "sequence_from_broadstreet": "MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA", "dna_sequence_from_broadstreet": "ATGCTGGCTTTCTTAAACCAGGTTCGCAAGCCGACCCTGGACCTTCCGCTCGAAGTGCGGCGCAAAATGTGGTTCAAACCGTTCATGCAATCCTACCTGGTGGTCTTTATCGGCTACCTGACGATGTACCTGATTCGCAAGAACTTTAACATCGCGCAGAACGATATGATTTCGACCTACGGGTTGAGCATGACGCAGCTGGGGATGATCGGCCTGGGTTTCTCCATCACTTATGGCGTGGGTAAAACGCTGGTTTCCTACTACGCCGACGGCAAAAACACCAAACAATTCCTGCCGTTCATGCTGATCCTCTCTGCTATTTGTATGCTGGGCTTCAGTGCCAGTATGGGCAGCGGCTCGGTTAGCCTGTTCCTGATGATTGCCTTCTACGCCTTAAGCGGCTTTTTCCAGAGTACCGGCGGTTCGTGCAGTTACTCCACCATCACCAAATGGACGCCGCGTCGTAAACGCGGGACATTCCTCGGTTTCTGGAATATTTCTCACAACCTTGGCGGTGCAGGCGCAGCAGGTGTGGCGCTGTTCGGGGCAAATTACCTGTTCGATGGCCATGTCATCGGCATGTTTATCTTCCCGTCGATTATCGCGCTGATTGTCGGTTTTATCGGCCTGCGTTACGGCAGCGACTCCCCGGAATCTTATGGCCTCGGCAAAGCTGAAGAACTGTTCGGCGAGGAGATCAGCGAAGAGGACAAAGAGACAGAATCTACCGATATGACCAAGTGGCAGATCTTTGTTGAGTATGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCGCCAACATTTTCCTCTATGTGGTACGTATTGGTATCGACCAGTGGTCAACCGTATACGCGTTCCAGGAACTGAAACTCTCTAAAGCGGTGGCGATTCAGGGCTTTACGCTGTTTGAAGCTGGTGCGCTGGTCGGTACGCTGCTGTGGGGCTGGCTCTCTGACCTGGCGAACGGTCGCCGTGGCCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACGCTCGGTGTGTATCAACATGCCAGTAACGAATATATCTATCTGGCTTCTCTCTTTGCGTTGGGTTTCCTGGTCTTTGGCCCGCAATTGTTGATTGGTGTGGCTGCTGTTGGCTTTGTACCTAAAAAAGCGATTGGCGCTGCCGATGGTATTAAAGGCACCTTTGCTTACCTGATTGGTGACAGCTTTGCCAAGTTAGGTCTGGGAATGATTGCCGATGGGACGCCGGTATTCGGCCTTACCGGCTGGGCAGGCACCTTCGCCGCGCTGGATATCGCCGCGATTGGTTGTATCTGCCTGATGGCGATAGTGGCGGTAATGGAAGAACGCAAAATCCGCCGCGAGAAAAAAATTCAGCAGTTGACAGTGGCATAA", "partial": "0", "query_start": 89219, "query_end": 90607, "orf_dna_sequence": "ATGCTGGCCTTTCTGAATCAGGTGCGCAAGCCGACCTTGGATCTGCCGCTCGATGTGCGGCGCAAAATGTGGTTCAAACCTTTCATGCAGTCCTATCTGGTGGTTTTCATCGGCTACCTGACCATGTACTTGATCCGCAAGAACTTTAACATCGCGCAGAACGACATGATCTCCACCTACGGGCTGAGCATGACCCAGCTGGGGATGATTGGCCTGGGCTTCTCCATCACCTACGGCGTGGGCAAGACGCTGGTCTCTTATTATGCCGACGGCAAAAACACCAAGCAGTTCCTGCCGTTTATGCTGATCCTCTCCGCCATCTGTATGCTGGGCTTTAGCGCCAGCATGGGGGCGGGTTCTACCAGCCTGTTCCTGATGATCGCCTTCTATGCGCTGAGCGGTTTCTTCCAGAGCACCGGCGGCTCGTGCAGCTATTCCACCATCACCAAGTGGACGCCCAGACGCAAACGCGGCACTTTCCTCGGCTTCTGGAATATCTCCCACAACCTCGGCGGCGCGGGCGCGGCGGGCGTGGCGCTGTTTGGCGCCAACTATCTGTTCGACGGCCATGTGATCGGCATGTTTATCTTCCCGTCGATTATTGCGCTGATCGTTGGCTTTATCGGCCTGCGCTACGGTAGCGACTCTCCGGAATCCTACGGCCTCGGCACGGCGGAAGAGCTGTTTGGCGAAGCGATCAGCGAAGAGGACAAAGAGACCGAAGAAAATGCGATGACCAAGTGGCAGATCTTTGTTGAGTACGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCTCCAACATCTTCCTCTACGTGGTGCGTATCGGTATCGATCAGTGGTCCACCGTGTACGCCTTCCAGGAGCTGAAGCTGTCGAAAGAGGTGGCGATTCAGGGCTTTACCCTGTTTGAGGTCGGCGCGCTGGTCGGCACGCTGCTGTGGGGCTGGCTGTCGGATCTGGCCAACGGCCGCCGCGCGCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACCCTCGGGGTTTACCAACACGCCAGCAACCAGTACGTCTATCTGGCCTCGTTATTTGCGCTGGGCTTCCTGGTGTTTGGTCCGCAGCTGTTGATCGGCGTCGCCGCCGTCGGTTTCGTACCGAAAAAAGCGATCGGCGCCGCCGATGGGATCAAGGGCACCTTCGCCTATCTGATCGGCGATAGCTTCGCCAAACTGGGTCTCGGGATGATCGCCGACGGCACCCCGGTCTTCGGCCTGACCGGCTGGGCCGGCACCTTTGCGGCGCTGGACGCCGCCGCCGTCGGCTGTATCTGCCTGATGGCCATCGTGGCTATCTTTGAAGAGCGTAAAATTCGCCGCGAGAAAAAGAACCGTATTTTGCAGACCGCCTGA", "orf_prot_sequence": "MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA", "perc_identity": 95.03}}, "NODE_59_length_1013_cov_103.874_1 # 1 # 1011 # 1 # ID=59_1;partial=11;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.547": {"gnl|BL_ORD_ID|2022|hsp_num:0": {"type_match": "Strict", "snp": {"original": "R", "change": "F", "position": 234}, "query_snp": {"original": "R", "change": "F", "position": 176}, "orf_strand": "+", "orf_start": 1, "orf_end": 1011, "orf_from": "NODE_59_length_1013_cov_103.874_1 ", "model_name": "Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin", "model_type": "protein variant model", "model_type_id": 40293, "pass_evalue": "n/a", "pass_bitscore": 700, "model_id": "2158", "ARO_accession": "3003369", "ARO_name": "Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin", "ARO_category": {"37711": {"category_aro_accession": "3001312", "category_aro_cvterm_id": "37711", "category_aro_name": "elfamycin resistant EF-Tu", "category_aro_description": "Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "36725": {"category_aro_accession": "3000586", "category_aro_cvterm_id": "36725", "category_aro_name": "pulvomycin", "category_aro_description": "Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance.", "category_aro_class_name": "Antibiotic"}, "37618": {"category_aro_accession": "3001219", "category_aro_cvterm_id": "37618", "category_aro_name": "elfamycin antibiotic", "category_aro_description": "Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 676.396, "max_identities": 331, "cvterm_id": "36763", "query": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGHLDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTINPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "match": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKI+ELAG LD+YIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKET K+TCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTI PHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "sequence_from_db": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "sequence_from_broadstreet": "MLSPEGESTIVRNIAVSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG", "dna_sequence_from_broadstreet": "GTGCTCTCTCCTGAAGGGGAGAGCACTATAGTAAGGAATATAGCCGTGTCTAAAGAAAAATTTGAACGTACAAAACCGCACGTTAACGTTGGTACTATCGGCCACGTTGACCACGGTAAAACTACTCTGACCGCTGCAATCACCACCGTACTGGCTAAAACCTACGGCGGTGCTGCTCGTGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACTTCTCACGTTGAATACGACACCCCGACCCGTCACTACGCGCACGTAGACTGCCCGGGGCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCTCAGATGGACGGCGCGATCCTGGTAGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAAATGGAAGTTCGTGAACTTCTGTCTCAGTACGACTTCCCGGGCGACGACACTCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCCTGGAACTGGCTGGCTTCCTGGATTCTTACATTCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCCGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAACGCGGTATCATCAAAGTTGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAGACTCAGAAGTCTACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAAGCCGCACACCAAGTTCGAATCTGAAGTGTACATTCTGTCCAAAGATGAAGGCGGTCGTCATACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGTACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGCGGCCGTACCGTTGGCGCGGGCGTTGTTGCTAAAGTTCTGGGCTAA", "partial": "0", "query_start": 1, "query_end": 1011, "orf_dna_sequence": "GCTCGCGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACCTCTCACGTTGAATATGACACCCCGACTCGCCACTACGCGCACGTAGACTGCCCGGGCCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCGCAGATGGACGGCGCGATCCTGGTTGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAGATGGAAGTTCGTGAACTGCTGTCTCAGTACGATTTCCCGGGCGACGACACCCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCATCGAACTGGCTGGCCACCTGGATACCTATATCCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCTGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAGCGCGGTATCATCAAAGTAGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAAACCGCGAAAACCACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAACCCGCACACCAAGTTCGAATCTGAAGTGTACATCCTGTCCAAAGATGAAGGCGGCCGTCACACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGCACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGC", "orf_prot_sequence": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGHLDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTINPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "perc_identity": 98.22, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}}, "NODE_11_length_157792_cov_39.2115_111 # 107958 # 108392 # 1 # ID=11_111;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.545": {"gnl|BL_ORD_ID|2040|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 107958, "orf_end": 108392, "orf_from": "NODE_11_length_157792_cov_39.2115_111", "model_name": "Escherichia coli marR mutant conferring antibiotic resistance", "model_type": "protein overexpression model", "model_type_id": 41091, "model_id": "431", "pass_evalue": "n/a", "pass_bitscore": "210", "ARO_accession": "3003378", "ARO_name": "Escherichia coli marR mutant conferring antibiotic resistance", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24177e-89, "bit_score": 251.906, "max_identities": 120, "cvterm_id": "36849", "query": "MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLACKGWIKRLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP", "match": "MKSTSDLFNE+IPLGRLI MVNQKKDRLLN+YLSP+DITA QF+VLCSIRC  CITPVELK VLSVD GA+TRMLDRL CKGW++RLPNP DKRGVLV+LT  GAA+CEQCHQ+VGQ LHQELTKNL+ADEVA LE LLKKVLP", "sequence_from_db": "MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP", "sequence_from_broadstreet": "MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP", "dna_sequence_from_broadstreet": "GTGAAAAGTACCAGCGATCTGTTCAATGAAATTATTCCATTGGGTCGCTTAATCCATATGGTTAATCAGAAGAAAGATCGCCTGCTTAACGAGTATCTGTCTCCGCTGGATATTACCGCGGCACAGTTTAAGGTGCTCTGCTCTATCCGCTGCGCGGCGTGTATTACTCCGGTTGAACTGAAAAAGGTATTGTCGGTCGACCTGGGAGCACTGACCCGTATGCTGGATCGCCTGGTCTGTAAAGGCTGGGTGGAAAGGTTGCCGAACCCGAATGACAAGCGCGGCGTACTGGTAAAACTTACCACCGGCGGCGCGGCAATATGTGAACAATGCCATCAATTAGTTGGCCAGGACCTGCACCAAGAATTAACAAAAAACCTGACGGCGGACGAAGTGGCAACACTTGAGTATTTGCTTAAGAAAGTCCTGCCGTAA", "partial": "0", "query_start": 107958, "query_end": 108389, "orf_dna_sequence": "ATGAAAAGTACCAGCGACCTGTTTAATGAAATGATCCCGCTGGGTCGCTTGATCCAGATGGTTAACCAGAAAAAAGATCGCCTGCTCAATGACTACCTCTCACCTATGGATATTACCGCGACCCAGTTTCGCGTGCTCTGCTCCATTCGTTGCGAAGTATGTATTACCCCCGTTGAGCTGAAAACCGTGCTTTCCGTCGACCCGGGCGCAATGACGCGCATGCTCGACCGCCTGGCGTGCAAAGGCTGGATTAAACGGTTACCCAACCCCGCTGACAAGCGCGGCGTGCTGGTGCAGTTGACGCCGGACGGCGCAGCCCTTTGCGAGCAGTGTCATCAGGTTGTGGGTCAGAAGTTACACCAGGAGTTAACGAAAAATCTGTCGGCGGACGAAGTCGCCATGCTTGAGCAACTGCTCAAGAAGGTCCTGCCGTAA", "orf_prot_sequence": "MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLACKGWIKRLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP", "perc_identity": 83.33}}, "NODE_152_length_397_cov_0.740741_1 # 1 # 270 # -1 # ID=152_1;partial=10;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.637": {"gnl|BL_ORD_ID|2412|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type B NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2693", "ARO_accession": "3004060", "ARO_name": "Type B NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2410|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type A NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2691", "ARO_accession": "3004059", "ARO_name": "Type A NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2409|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type A NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2691", "ARO_accession": "3004059", "ARO_name": "Type A NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2149|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "375", "model_id": "2306", "ARO_accession": "3003807", "ARO_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.11739, "max_identities": 14, "bit_score": 23.483, "cvterm_id": "36849", "query": "TLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEH-----AEPLEALQRLI", "match": "+L E+A+AAGV++  ++     + +L   + +  E+ + ++    +LE+      +PL  L+ ++", "sequence_from_db": "SLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGEL----ELEYQAKFPGDPLSVLREIL", "sequence_from_broadstreet": "MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE", "dna_sequence_from_broadstreet": "ATGGCACGAAAAACCAAACAAGAAGCGCAAGAAACGCGCCAACACATCCTCGATGTGGCTCTACGTCTTTTCTCACAGCAGGGGGTATCATCCACCTCGCTGGGCGAGATTGCAAAAGCAGCTGGCGTTACGCGCGGTGCAATCTACTGGCATTTTAAAGACAAGTCGGATTTGTTCAGTGAGATCTGGGAACTGTCAGAATCCAATATTGGTGAACTAGAGCTTGAGTATCAGGCAAAATTCCCTGGCGATCCACTCTCAGTATTAAGAGAGATATTAATTCATGTTCTTGAATCCACGGTGACAGAAGAACGGCGTCGATTATTGATGGAGATTATATTCCACAAATGCGAATTTGTCGGAGAAATGGCTGTTGTGCAACAGGCACAACGTAATCTCTGTCTGGAAAGTTATGACCGTATAGAACAAACGTTAAAACATTGTATTGAAGCGAAAATGTTGCCTGCGGATTTAATGACGCGTCGCGCAGCAATTATTATGCGCGGCTATATTTCCGGCCTGATGGAAAACTGGCTCTTTGCCCCGCAATCTTTTGATCTTAAAAAAGAAGCCCGCGATTACGTTGCCATCTTACTGGAGATGTATCTCCTGTGCCCCACGCTTCGTAATCCTGCCACTAACGAATAA", "partial": "0", "query_start": 73, "query_end": 252, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 21.54}}}
\ No newline at end of file
diff -r 000000000000 -r d2590ecc4189 test-data/rgi/rgi.txt
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/rgi/rgi.txt	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,42 @@
+ORF_ID	Contig	Start	Stop	Orientation	Cut_Off	Pass_Bitscore	Best_Hit_Bitscore	Best_Hit_ARO	Best_Identities	ARO	Model_type	SNPs_in_Best_Hit_ARO	Other_SNPs	Drug Class	Resistance Mechanism	AMR Gene Family	Predicted_DNA	Predicted_Protein	CARD_Protein_Sequence	Percentage Length of Reference Sequence	ID	Model_ID	Nudged	Note
+NODE_1_length_803036_cov_42.265_33 # 30758 # 31933 # 1 # ID=1_33;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.599	NODE_1_length_803036_cov_42.265_33	30758	31933	+	Perfect	670	798.119	oqxA	100.0	3003922	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCGCAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACCGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTGGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAGAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTTGGCGAGGAAGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACACCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCTGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACTGTTGCCATGACCTCCAGCGCCACCCTTAACTGA	MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN	MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN	100.00	gnl|BL_ORD_ID|2216|hsp_num:0	2399		
+NODE_1_length_803036_cov_42.265_34 # 31957 # 35109 # 1 # ID=1_34;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.612	NODE_1_length_803036_cov_42.265_34	31957	35109	+	Strict	2000	2107.8	oqxB	99.52	3003923	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTTTCGCCAAACGGTAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCGGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGCTGATCGCGGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGTCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGGCTGGTGAGCAAAACCCTCGGACGCCGTGGCGCGGTGTTTGCGGTGTATCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATTAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTCTCCATCCTGCCGCCGCCGATTTTAGGACTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGAGCTATTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCCGATGGGCCATTCCGCGAGAGCGTGGAAGATATTGCTAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTGCCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAGGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCGTTCCTCGTGCTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCGTGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTATTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTGCGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCTCGCCTAG	MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA	MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA	100.00	gnl|BL_ORD_ID|2217|hsp_num:0	2400		
+NODE_1_length_803036_cov_42.265_80 # 79380 # 79910 # 1 # ID=1_80;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.520	NODE_1_length_803036_cov_42.265_80	79380	79910	+	Strict	280	338.961	emrR	92.57	3000516	protein homolog model	n/a	n/a	fluoroquinolone antibiotic	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGGATAGTTCGTTTACTCCCATTGAGCAAATGCTCAAGTTCCGCGCCAGCCGCCATGAAGATTTCCCGTTTCAGGAGATCCTGTTAACTCGTCTTTGCATGCATATGCAAGGTAAGCTGCTGGAAAATCGCAATAAAATGCTCAAAGCGCAGGGAATTAACGAGACATTATTTATGGCGCTGATTACGCTGGAGTCACAGGAAAACCACAGCATCCAGCCGTCCGAGCTGAGCTGTGCGCTGGGCTCGTCACGTACCAACGCCACCCGTATCGCTGATGAACTGGAAAAACGCGGCTGGATTGAGCGCCGCGAGAGCGATAACGATCGTCGCTGTTTGCATCTGCAACTGACCGAAAAGGGCCATCAGTTTTTGCGTGAAGTCCTGCCGCCGCAGCATAACTGCCTGCATCAGCTGTGGTCTTCACTTAGCACCAGCGAAAAAGATCAGCTCGAACACATCACCCGCAAACTCCTGAGCCGCCTTGATCAGATGGAAGAAGAAGGCGTGCTAGCGGACTCTCTACGCTAA	MDSSFTPIEQMLKFRASRHEDFPFQEILLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHQFLREVLPPQHNCLHQLWSSLSTSEKDQLEHITRKLLSRLDQMEEEGVLADSLR	MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS	100.00	gnl|BL_ORD_ID|1251|hsp_num:0	1330		
+NODE_1_length_803036_cov_42.265_81 # 80036 # 81208 # 1 # ID=1_81;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.594	NODE_1_length_803036_cov_42.265_81	80036	81208	+	Strict	700	788.875	Klebsiella pneumoniae KpnG	99.74	3004588	protein homolog model	n/a	n/a	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACGCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTGCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCGCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACCGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATTGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGCACCGGCAGCGCCTTCTCTCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGTCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA	MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG	MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG	100.00	gnl|BL_ORD_ID|2786|hsp_num:0	3298		
+NODE_1_length_803036_cov_42.265_82 # 81224 # 82762 # 1 # ID=1_82;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=3-4bp;gc_cont=0.612	NODE_1_length_803036_cov_42.265_82	81224	82762	+	Strict	700	937.947	Klebsiella pneumoniae KpnH	94.02	3004597	protein homolog model	n/a	n/a	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGCGACGTTCATGCAGGTGCTGGATTCCACTATCGCCAACGTGGCGATCCCGACCATTGCCGGCAACCTTGGCTCGTCGCTGAGCCAGGGGACCTGGGTCATCACCTCGTTCGGGGTCGCTAACGCCATCTCCATCCCGATCACCGGCTGGCTGGCCAAGCGCGTCGGCGAGGTGAAGCTGTTCCTGTGGTCAACCACCGCCTTCGCCATTGCCTCCTGGGCCTGCGGCGTCTCCAACAGCCTGACGATGCTGATTTTCTTCCGCGTCATTCAGGGGATCGTCGCCGGACCGCTGATCCCGCTGTCGCAAAGTCTGCTGCTCAGCAACTATCCCCCGGCGAAGCGCTCTATCGCTCTGGCGCTGTGGTCAATGACGGTGATTGTCGCGCCCATCTGCGGTCCGATCCTCGGCGGCTATATCAGCGATAACTATCACTGGGGCTGGATCTTCTTTATCAACGTGCCCATTGGCGTGGCGGTGGTGCTGATGACCCTGCAGACCCTGCGCAACCGGGAAACCAAAACCGAACAGCGGCGGATCGACGGTGTCGGTCTGGCGCTGCTGATCATCGGTATCGGTAGCCTGCAGGTGATGCTGGACCGGGGTAAAGAGCTGGACTGGTTCTCCTCCAATGAGATTATCATTCTGACCATCGTGGCGGTGGTGGCGATAAGCTTCCTGATCGTCTGGGAGCTAACCGACGATAACCCGATTGTCGATCTGTCGCTATTTAAGTCGCGCAACTTCACCATCGGCTGCCTCTGTATCAGTCTGGCCTATATGCTCTACTTCGGCGCCATCGTGCTGCTGCCGCAGCTGTTGCAGGAGGTCTACGGTTACACCGCGACCTGGGCCGGCCTGGCGTCGGCGCCGGTGGGGGTGATCCCGGTCATTCTGTCGCCGATTATCGGCCGCTTCGCGCATAAGCTCGACATGCGGCGGCTGGTCACCTTCAGCTTTATTATGTACGCGGTCTGCTTCTACTGGCGCGCCTGGACCTTCGAACCGGGGATGGACTTTGGCGCCTCGGCGTGGCCACAGTTTATCCAGGGCTTCGCGGTGGCCTGCTTCTTCATGCCGTTGACCACCATCACCCTCTCCGGCCTGCCGCCGGAGCGGCTGGCGGCGGCGTCGAGCCTGTCGAACTTCACCCGTACCCTTGCCGGCTCCATCGGGACCTCGATCACCACCACCCTGTGGACCAACCGCGAGGCGCTGCATCATGCGCAGCTCACCGAATCGGTGACCCCCTTTAACCCCAACGCGCAGCAGATATACGATCAGCTGCAGGGCATGGGAATGACGCAGCAGCAGGCGTCCGGCTGGATAGCGCAGCAGATAACCAACCAGGGGCTGATTATCTCCGCCAACGAAATCTTCTGGATTTCTGCGGCTATTTTCATCCTGCTGTTGGGGCTGGTGTGGTTCGCCAGACCACCGTTCAGCGCCGGCGGAGGCGGCGGCGGCGCGCACTAG	MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPFSAGGGGGGAH	MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPFGAGGGGGGAH	100.00	gnl|BL_ORD_ID|2787|hsp_num:0	3299		
+NODE_3_length_454317_cov_40.2449_14 # 17656 # 20778 # 1 # ID=3_14;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.646	NODE_3_length_454317_cov_40.2449_14	17656	20778	+	Strict	1800	1835.85	mdtB	90.1	3000793	protein homolog model	n/a	n/a	aminocoumarin antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGCAGGTGTTACCCCCAGGCCGCACCGGCGGCCCGTCCCGGCTGTTTATTATGCGTCCGGTGGCCACCACTCTGCTGATGGTGGCTATCCTGCTGGCCGGGATCATCGGCTACCGCTTTCTGCCGGTCTCCGCCCTGCCGGAGGTCGATTACCCGACCATTCAGGTAGTCACCCTCTATCCGGGCGCCAGCCCGGACGTGGTGACCTCCGCCATCACCGCCCCGCTGGAGCGCCAGTTCGGCCAAATGTCAGGCCTCAAGCAGATGTCGTCGCAAAGCTCCGGCGGCGCCTCGGTAGTCACGCTGCAGTTCCAGCTGACCCTGCCGCTGGACGTCGCCGAGCAGGAAGTGCAGGCGGCCATTAACGCCGCCACCAACCTGCTGCCGAGCGATCTGCCCAACCCGCCGGTCTACAGCAAGGTGAACCCGGCGGATCCGCCGATCATGACTCTCGCCGTCACCTCCTCCGCCATCCCGATGACCCAGGTTGAGGACATGGTGGAGACCCGGGTGGCGCAGAAGATCTCCCAGGTTTCCGGCGTCGGTCTGGTGACCCTCGCCGGCGGCCAGCGCCCGGCGGTGCGGGTGAAGCTTAACGCCCAGGCCATCGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCTATCACCAGCGCCAACGTTAACTCCGCGAAAGGCAGCCTCGACGGTCCGGCCCGCGCGGTGACGCTTTCCGCTAACGATCAGATGCAGTCCGCTGAGGATTATCGCCGGCTGATTATCGCTTATCAGAACGGGGCGCCGATCCGGCTCGGCGATGTCGCCAGCGTCGAACAAGGGGCCGAAAACAGCTGGCTCGGGGCGTGGGCCAACCAGCAGCGGGCCATCGTGATGAACGTCCAGCGCCAGCCGGGGGCCAACATCATCGACACCGCCGACAGCATTCGCCAGATGCTGCCGCAGCTTACCGAGAGCCTGCCGAAATCGGTGAAGGTGCAGGTCCTCTCCGACCGGACCACCAACATCCGCGCCTCGGTGCGCGACACCCAGTTTGAGCTGATGCTGGCCATCGCCCTGGTGGTGATGATCATCTACCTGTTTCTGCGCAACGTGCCGGCGACCATTATTCCCGGCGTCGCGGTGCCGCTGTCGCTGGTGGGCACTTTCGCGGTGATGGTGTTCCTCGACTTCTCGATCAACAACCTGACGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGATGCCATCGTGGTGATCGAGAACATCTCGCGCTATATCGAAAAAGGCGAGAAGCCGCTGGCCGCCGCGCTGAAGGGCGCGGGGGAGATCGGCTTCACCATCATCTCCCTCACCTTCTCGCTGATCGCGGTGCTGATCCCGCTGCTGTTTATGGGCGATATCGTCGGCCGCCTGTTCCGCGAATTCGCCGTCACCCTTGCCGTCGCTATTCTTATCTCGGCGGTGGTCTCCCTGACCCTGACGCCGATGATGTGCGCTCGTATGCTAAGCCACGAATCGCTGCGCAAGCAGAACCGATTCTCGCGGGCCAGCGAGCGTTTCTTCGAACGGGTGATCGCCGTCTATGGCCGCTGGCTGAGCCGGGTGCTGAACCATCCGTGGCTGACGCTCGGCGTCGCCCTGAGCACCCTGGCGCTGTCGATTATCCTGTGGGTCTTTATCCCGAAAGGCTTTTTCCCGATCCAGGATAACGGCATTATCCAGGGTACCCTCCAGGCGCCGCAGTCGGTCTCCTTCGCCAGCATGGCCGAGCGCCAGCGGCAGGTGGCCAGCATTATCCTTAAGGATCCGGCGGTGGAGAGTCTGACCTCCTTCGTCGGCGTCGACGGCACCAACCCGGCGCTGAACAGCGCCCGTCTGCAGATCAACCTCAAGCCGCTGGATGAACGCGACGATCGCGTCCAGACGGTGATAAGCCGCCTGCAGCAGGCGGTGGACGGCGTCCCCGGCGTGGCGCTCTACCTGCAGCCGACCCAGGACCTGACCATCGACACCACGGTGAGCCGCACCCAGTATCAGTTCACCCTGCAGGCAAACTCCCTCGAGGCGCTGAGCACCTGGGTACCGCCGCTGCTCAGCCGTCTGCAGGCCCAGCCGCAGCTGGCCGACGTCAGCAGCGACTGGCAGGACAAAGGCCTGGCCGCCTATATCAAGGTGGATCGCGACAGCGCCAGCCGCCTCGGTATCTCAATGGCCGATGTCGATAATGCGCTGTACAACGCCTTCGGCCAGCGGCTGATCTCCACTATTTACACTCAGGCGAATCAGTATCGCGTGGTGCTCGAGCAGGATACCGAGGCGACGCCGGGCCTGGCGGCGCTGGAGAATATCCGTCTCACCAGCAGCGACGGCGGCATCGTGCCGTTGACCGCCATCGCCACGGTGGAGCAGCGCTTTACCCCGCTGTCGGTGAACCACCTCGATCAGTTCCCGGTGACCACCATCTCGTTTAACGTCCCGGACAACTACTCGCTGGGCGAAGCGGTGGAGGCGATCCTCGCCGCCGAACAGTCGCTGGATTTCCCGACCGATATTCGCACCCAGTTCCAGGGCAGCTCGCTGGCCTTCCAGTCGGCGCTCGGCAGCACCGTCTGGCTGGTGGTCGCCGCGGTGGTGGCGATGTATATCGTGCTGGGGGTGCTGTACGAGAGCTTTATCCATCCGATCACGATTCTCTCCACCCTGCCCACCGCCGGGGTCGGGGCGCTGCTGGCGCTGTGGCTGGCGGGCAGCGAGCTGGACGTGATCGCCATCATCGGAATCATTCTGCTGATCGGCATCGTGAAGAAGAACGCCATCATGATGATCGACTTCGCGCTGGCCGCTGAGCGCGAGCAGGGCATGCCGCCGCGGGAGGCGATCTACCAGGCCTGTCTGCTGCGTTTTCGGCCGATCCTGATGACTACCCTCGCCGCCCTGCTCGGCGCCCTGCCGCTGATGCTGAGCACCGGCGTCGGCGCCGAGCTGCGGCGTCCGCTGGGGATCGGCATGGTCGGCGGTCTGATGCTCAGCCAGGTGCTGACCCTGTTCACCACCCCGGTGATCTATCTGCTGTTCGACCGCCTGTCGCTGCACCTGAAGCGCCGCTTCCCGCGTCAGGAAGAGGAGGCGTAA	MQVLPPGRTGGPSRLFIMRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAIPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETVRTAITSANVNSAKGSLDGPARAVTLSANDQMQSAEDYRRLIIAYQNGAPIRLGDVASVEQGAENSWLGAWANQQRAIVMNVQRQPGANIIDTADSIRQMLPQLTESLPKSVKVQVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNVPATIIPGVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERFFERVIAVYGRWLSRVLNHPWLTLGVALSTLALSIILWVFIPKGFFPIQDNGIIQGTLQAPQSVSFASMAERQRQVASIILKDPAVESLTSFVGVDGTNPALNSARLQINLKPLDERDDRVQTVISRLQQAVDGVPGVALYLQPTQDLTIDTTVSRTQYQFTLQANSLEALSTWVPPLLSRLQAQPQLADVSSDWQDKGLAAYIKVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEQDTEATPGLAALENIRLTSSDGGIVPLTAIATVEQRFTPLSVNHLDQFPVTTISFNVPDNYSLGEAVEAILAAEQSLDFPTDIRTQFQGSSLAFQSALGSTVWLVVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALWLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMPPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLMLSQVLTLFTTPVIYLLFDRLSLHLKRRFPRQEEEA	MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA	100.00	gnl|BL_ORD_ID|774|hsp_num:0	820		
+NODE_3_length_454317_cov_40.2449_15 # 20779 # 23856 # 1 # ID=3_15;partial=00;start_type=GTG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.638	NODE_3_length_454317_cov_40.2449_15	20779	23856	+	Strict	1800	1862.04	mdtC	91.41	3000794	protein homolog model	n/a	n/a	aminocoumarin antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	GTGAAGTTTTTCGCCCTCTTCATTTACCGCCCGGTGGCGACGATCCTCATCTCGCTGGCCATCACCCTGTGCGGCATTCTCGGCTTCCGGCTGCTGCCGGTAGCCCCGCTGCCGCAGGTGGACTTCCCGGTGATCATGGTTAGCGCCTCGCTGCCGGGAGCCTCGCCGGAGACCATGGCCTCGTCGGTGGCCACCCCACTGGAGCGCTCCCTGGGGCGGATTGCCGGGGTCAATGAGATGACCTCCTCCAGCTCGCTCGGCAGCACCCGCATCATTCTTGAGTTTAACTTCGACCGCGATATCAACGGCGCGGCGCGCGACGTTCAGGCGGCGATCAACGCCGCGCAAAGCCTGCTGCCGAGCGGAATGCCCAGCCGGCCGACCTATCGCAAAGCTAATCCGTCAGATGCGCCGATCATGATCCTGACGCTGACCTCGGACACCTACTCCCAGGGTGAGCTGTATGATTTCGCCTCCACCCAGCTGGCGCAGACCATCGCGCAGATCGACGGCGTGGGCGATGTCGACGTCGGCGGCAGCTCCCTGCCGGCGGTGCGCGTCGACCTCAACCCGCAGGCGCTGTTTAACCAGGGCGTGTCGCTGGACGCGGTGCGCACCGCCATCAGCGACGCCAACGTGCGCAAACCGCAGGGGGCGCTGGAGGACAGCGCGCACCGCTGGCAGGTGCAGACCAACGATGAGCTGAAGACCGCCGCCGACTATCAGCCGCTGATCGTCCACTACCAGAATGGCGCCGCGGTGCGGCTGGGAGATGTCGCCACCGTCTCGGATTCGGTGCAGGACGTACGCAACGCCGGGATGACCAACGCCAAACCGGCGATCCTGCTGATGATCCGCAAACTGCCGGAAGCCAATATTATCCAGACGGTGGACAGCATCCGCGCCCGCCTGCCGGAGCTGCAGCAGACCATTCCGGCGGCTATCGACCTGCAGATCGCCCAGGACCGCTCGCCGACCATCCGCGCCTCGCTGGAGGAGGTGGAGCAGACGCTGGTGATTTCGGTGGCGCTGGTGATCCTCGTGGTGTTCCTGTTCCTGCGCTCGGGGCGCGCCACGCTGATCCCGGCCGTCGCCGTCCCGGTATCCTTAATCGGTACCTTCGCCGCGATGTATTTGTGCGGCTTCAGCCTCAATAACCTGTCGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGACGCTATCGTGGTGCTGGAGAATATCTCCCGCCATCTGGAGGCGGGGATGAAACCGCTGCAGGCGGCGCTGCAGGGGAGCCGCGAGGTCGGCTTTACCGTGCTGTCGATGAGCCTGTCGCTGGTGGCGGTGTTTCTGCCGCTGCTGCTGATGGGCGGCCTGCCCGGCCGCCTGCTGCGCGAGTTCGCCGTCACCCTGTCGGTGGCGATCGGCATCTCGCTGGCGGTCTCCCTCACCCTGACGCCGATGATGTGCGGCTGGCTGCTGAAAAGCGGCAAGCCCCACCAGCCGACGCGCAACCGCGGCTTTGGCCGCCTGCTGGTGGCCATGCAGGGCGGCTATGGTAAATCGTTAAAATGGGTACTGAAGCACAGCCGGCTGACCGGCCTGGTGGTGCTGGGCACCATCGTCCTCAGCGTTTGGCTCTACATTTCGATCCCGAAAACCTTCTTCCCGGAGCAGGACACCGGGGTGCTGATGGGCGGCATTCAGGCCGACCAGAGCATCTCCTTCCAGGCGATGCGCGGCAAGCTGCAGGACTTTATGAAGATCATTCGCGAAGATCCGGCGGTGGATAACGTCACCGGCTTTACCGGCGGCTCGCGGGTCAACAGCGGGATGATGTTTATCACCCTCAAGCCGCGCGACCAGCGCCACGAGACGGCGCAGCAGGTGATCGACCGGCTGCGCAAAAAGCTGGCCAACGAGCCCGGGGCCAACCTGTTCCTGATGGCGGTGCAGGATATCCGCGTCGGCGGCCGGCAGTCGAACGCCAGCTATCAGTACACCCTGCTGTCCGACGACCTGTCGGCGCTGCGCGAGTGGGAGCCGAAGATCCGCAAAGCGCTGGCGGCGCTGCCGGAGCTGGCGGACGTCAACTCCGATCAGCAGGACAATGGCGCCGAAATGGACCTGGTCTATGACCGGGATACCATGTCGCGCCTCGGCATCAGCGTCCAGGACGCCAACAACCTGCTGAACAACGCCTTTGGCCAGCGGCAGATCTCTACCATCTACCAGCCGCTCAACCAGTATAAGGTGGTGATGGAGGTGGATCCGGCCTACACCCAGGACGTCAGCGCCCTGGATAAGATGTTCGTCATTAACAGCGACGGCAAGCCGATCCCGCTGGCCTACTTCGCCAAATGGCAGCCGGCCAATGCCCCGCTGTCGGTGAACCACCAGGGGCTGTCGGCGGCATCCACTATCTCCTTTAACCTGCCCACCGGCCGCTCGCTGTCGGAAGCCAGCGAGGCCATTGACCGCGCGATGACCCAGCTCGGGGTGCCGTCGAGCGTGCGCGGCTCCTTTGCCGGTACCGCTCACGTGTTCCAGCAGACCATGAACGCGCAGGTGATCCTGATCCTCGCGGCTATCGCCACGGTCTATATCGTGCTGGGGGTGCTATATGAGAGCTATGTGCATCCGTTGACCATCCTCTCGACGCTGCCCTCCGCCGGGGTGGGCGCTCTGCTGGCGCTGGAGATCTTCGATGCCCCGTTCAGCCTAATCGCCCTGATTGGGATTATGTTATTAATTGGCATCGTTAAGAAAAACGCCATCATGATGGTTGATTTTGCCCTGGAGGCGCAGCGCAACGGCAACCTGACGCCGGAAGAGGCGATTTTCCAGGCCTGCCTGCTGCGTTTCCGGCCGATTATGATGACCACCCTCGCCGCGCTGTTCGGCGCCCTGCCGCTGGTGCTCTCCGGGGGCGATGGCTCTGAGCTGCGCCAGCCGCTGGGGATCACCATCGTCGGCGGTCTGGTGATGAGCCAGCTGTTAACGCTCTACACCACGCCGGTGGTCTATCTTTTCTTTGACCGTCTGCGGCTGCGTTTTTCGCGTCACTCCTCTCAACCGGTAAGCGAATAA	MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAMQGGYGKSLKWVLKHSRLTGLVVLGTIVLSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSDGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASEAIDRAMTQLGVPSSVRGSFAGTAHVFQQTMNAQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE	MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE	100.00	gnl|BL_ORD_ID|1239|hsp_num:0	1315		
+NODE_3_length_454317_cov_40.2449_18 # 26745 # 27467 # 1 # ID=3_18;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.611	NODE_3_length_454317_cov_40.2449_18	26745	27467	+	Strict	450	454.136	baeR	90.83	3000828	protein homolog model	n/a	n/a	aminoglycoside antibiotic; aminocoumarin antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGACTGAATTGCCTGTAGATGAAAACACCCCACGCATCCTTATCGTGGAAGATGAACCGAAGCTCGGCCAACTGCTGATTGATTATCTGCAGGCCGCCGGCTATGCGCCTGCGTTGATTAACCACGGCGACAAGGTCCTGCCCTACGTCCGCCAGTCGCCGCCGCACCTGATCCTGCTGGATCTGATGCTGCCCGGTACCGACGGTCTGACGCTGTGCCGGGAAATTCGCCGCTTCTCCGATGTTCCGGTGGTGATGGTGACGGCGAAAATCGAAGAGATCGACCGTTTGCTGGGGCTGGAAATAGGCGCCGACGACTATGTCTGCAAGCCCTACAGCCCGCGGGAAGTGGTCGCCCGGGTAAAAACCATCCTCCGCCGCTGCAAGCCGCAGCGCGATCTGCAGGCGCTGGACGCCCAGAGCCCGCTGATTGTCGACGAAGGTCGTTTTCAGGCCTCCTGGCGCGACAAGCTGCTGGACCTCACTCCCGCCGAGTTCCGGCTGCTGAAAACCCTCTCCCAGGAGCCGGGCAAAGTGTTCTCCCGCGAACAGCTACTCAACCATCTGTATGACGATTATCGGGTAGTCACCGATCGCACCATCGACAGCCACATCAAGAACCTGCGGCGCAAGCTGGAGGCGCTGGACGCCGAGCAGTCGTTTATCCGCGCGGTGTATGGCGTTGGCTACCGCTGGGAAGCGGACGCCTGCCGGCTGGCGTAG	MTELPVDENTPRILIVEDEPKLGQLLIDYLQAAGYAPALINHGDKVLPYVRQSPPHLILLDLMLPGTDGLTLCREIRRFSDVPVVMVTAKIEEIDRLLGLEIGADDYVCKPYSPREVVARVKTILRRCKPQRDLQALDAQSPLIVDEGRFQASWRDKLLDLTPAEFRLLKTLSQEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEALDAEQSFIRAVYGVGYRWEADACRLA	MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV	100.00	gnl|BL_ORD_ID|1258|hsp_num:0	1337		
+NODE_3_length_454317_cov_40.2449_285 # 330238 # 333351 # 1 # ID=3_285;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.609	NODE_3_length_454317_cov_40.2449_285	330238	333351	+	Strict	1900	1949.48	acrD	90.94	3000491	protein homolog model	n/a	n/a	aminoglycoside antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGGCGAATTTCTTTATCGATCGCCCCATTTTTGCATGGGTGCTGGCAATCCTGTTATGCCTGACGGGCGCCCTTGCCATTTTGTCGCTGCCGGTTGAACAGTATCCCGACCTCGCCCCGCCGAATGTGCGGATCACCGCCAACTATCCCGGCGCCTCCGCGCAAACCCTGGAGAATACCGTCACTCAGGTTATCGAACAGAATATGACCGGCCTCGATAACCTGATGTATATGTCCTCCCAGAGCAGCGCCACCGGCCAGGCGACGATCACCCTCAGCTTTACCGCCGGTACCGACCCGGATGAAGCCGTGCAGCAGGTTCAGAACCAGCTACAGTCGGCGATGCGTAAGCTGCCGCAGGCGGTGCAAAACCAGGGGGTGACGGTGCGCAAGACCGGTGATACCAATATCCTGACGCTCGCCTTCGTCTCCACTGACGGCAGTATGGATAAACAAGATATCGCCGACTACGTCGCCAGTAACATCCAGGACCCGCTCAGCCGCGTCAACGGCGTGGGGGATATCGACGCCTACGGTTCGCAATACTCAATGCGCATCTGGCTCGACCCGGCGAAGCTCAACAGCTACCAGATGACCACCAAGGATGTTACCGACGCCATCAGTTCGCAGAACGCCCAGATTGCCGTCGGCCAGCTTGGCGGGACGCCTTCGGTCGATAAGCAAGCGCTGAACGCCACCATCAACTCGCAATCTCTGCTGCAAACCCCGGAGCAGTTCCGCAATATCACTCTGCGCGTCAATCAGGATGGTTCAGAGGTGACGCTGGGCGATGTCGCCACCGTCGAGATGGGGGCGGAGAAGTACGACTATCTTAGCCGCTACAACCGCCAGCCGGCCTCAGGCCTCGGGATCAAGCTGGCTTCCGGCGCCAACGAAATGGCCACCGCGGAGCGCGTGATCAATCGCCTCAATGAGCTGGCGCAGTTTTTCCCCCACGGTCTGGAATATAAGGTCGCCTACGAGACCACCTCCTTCGTGAAGGCTTCCATCACCGACGTGGTGAAAACCCTGCTGGAGGCAATCCTGCTGGTCTTCCTCGTGATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGATGGGCACTTTCGCGGTGCTGTATGCCTGTGGTTACAGCATTAACACCCTGACGATGTTCGCGATGGTGTTGGCGATCGGCCTGCTGGTGGATGACGCCATCGTGGTGGTGGAGAACGTCGAGCACATCATGAGCGAGGAGGGCCTGTCGCCACGCGAGGCGACCCGCAAATCGATGGGACAAATTCAGGGCGCGCTGGTAGGGATCGCGATGGTGCTGTCGGCGGTATTTGTGCCGATGGCCTTCTTCGGCGGCACCACCGGCGCCATCTATCGCCAGTTCTCAATCACTATCGTCGCGGCGATGGTCCTCTCGGTGCTGGTGGCCATGATCCTCACCCCTGCCCTTTGCGCCACGCTGCTTAAGCCGGTTAAGCCAGGTGAATCCCATGAAAGAACAGGCTTCTTCGGCTGGTTCAACCGCACCTTCAACCGCAGCGCCAGCCGCTACGAAACCTTCGTCGGCAAAATCCTGCACCGCTCGCTGCGCTGGATGCTGATCTACGTCCTCCTGCTCGGCGGGATGGTGTTCCTGTTTCTGCATTTGCCGACCTCGTTCCTGCCGCTGGAGGATCGCGGGATGTTCACCACCTCGGTCCAGTTGCCGAGCGGCAGCACCCAGCAGCAGACGCTGAAGGTGGTGCAGAAGGCGGAAGATTACTTTCTCAATAACGAGAAGCAGAACGTCGAGTCGGTGTTCGCTACCGTTGGCTCCGGCCCCGGCGGCAATGGGCAGAACGTGGCCCGCATGTTCGTTCGTCTCAAAGACTGGGACCAGCGCGACCCGCAAACCGGCACCTCCTTTGCCATTATTGAACGCGCCACCAAAGCGTTTAATCAGATTAACGAAGCGCGGGTTATCGCCAGCAGCCCGCCGGCGATCAGCGGCCTCGGCAGTTCGGCAGGCTTCGATATGGAGCTGGAGGATCATGCCGGGAAGGGGCACGATGCGCTGATGGCGGCGCGCGATACGCTGCTTGAGCTGGCCGGGAAAAATCCGCTGTTGACCCGCGTCCGGCATAACGGGCTCGATGACAGTCCGCAGCTGCAGGTCGATATCGATCAGCGTAAAGCGCAGGCGCTGGGCGTCTCCATTGACGACATCAACGATACGCTGCAAACCGCGTGGGGGTCGAGCTACGTCAACGACTTTATGGATCGCGGCCGGGTAAAGAAAGTCTACGTCCAGGCGGCGGCGAAATACCGGATGCTGCCTGACGATATCAATCTTTGGTACGTGCGCAACAGCAGCGGCACGATGGTGCCATTCTCGGCCTTCGCCACCTCGCGCTGGGAGACCGGCTCGCCGCGGCTGGAGCGCTACAATGGCTACTCAGCGGTCGAGATCGTCGGTGAGGCGGCGCCGGGTATCAGTACCGGTACCGCGATGGACATGATGGAGAAGCTGGCCGCGCAGTTACCCACCGGCTTTGGCCTCGAATGGACCGCCATGTCCTACCAGGAACGCCTCTCTGGCGCTCAGGCGCCGGCCCTGTATGCTATTTCTCTGCTGGTGGTGTTCCTGTGCCTGGCGGCGCTGTACGAGAGCTGGTCGGTGCCGTTCTCGGTGATGCTGGTGGTGCCGCTGGGGGTGATTGGCGCCCTGCTGGCGACCTGGATGCGCGGTCTGGAGAATGACGTGTACTTCCAGGTGGGTCTGTTGACGGTGATCGGCCTGTCGGCGAAAAACGCCATTCTGATCGTCGAGTTCGCCAATGAGCTCAACGAGAAGGGCCAGGATCTGCTCAGCGCCACGCTGTCGGCTTGCCGTCAGCGCCTGCGCCCCATCCTGATGACCTCGCTGGCGTTCATCTTCGGCGTGCTGCCGATGGCGACCAGCACCGGCGCCGGTTCCGGCAGCCAGCATGCGGTCGGCACCGGAGTGATGGGCGGGATGATCTCCGCCACCGTGCTGGCGATCTTTTTCGTGCCGCTGTTCTTTGTGCTGGTGCGTCGCCGTTTTCCGCTAAAGGAGCGTCCGCAATAA	MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ	MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE	100.00	gnl|BL_ORD_ID|1341|hsp_num:0	1427		
+NODE_4_length_367278_cov_42.3139_12 # 14037 # 14456 # 1 # ID=4_12;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.614	NODE_4_length_367278_cov_42.3139_12	14037	14456	+	Strict	280	283.108	FosA6	97.84	3004111	protein homolog model	n/a	n/a	fosfomycin	antibiotic inactivation	fosfomycin thiol transferase	ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA	MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ	MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAIWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQQYKGMVFFDQ	100.00	gnl|BL_ORD_ID|2472|hsp_num:0	2779		
+NODE_6_length_262587_cov_42.4347_106 # 86156 # 87349 # 1 # ID=6_106;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.562	NODE_6_length_262587_cov_42.4347_106 	86156	87349	+	Strict	770	738.028	Klebsiella pneumoniae acrA	95.24	3004041	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA	MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS	MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQKSPLRSAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS	99.75	gnl|BL_ORD_ID|2388|hsp_num:0	2659	True	loose hit with at least 95 percent identity pushed strict
+NODE_6_length_262587_cov_42.4347_107 # 87372 # 90518 # 1 # ID=6_107;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.569	NODE_6_length_262587_cov_42.4347_107	87372	90518	+	Strict	1900	1941.39	acrB	91.52	3000216	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGCCTAATTTCTTTATCGATCGCCCCATATTTGCATGGGTGATCGCCATTATCATCATGCTGGCTGGGGGATTATCGATCCTCAAATTGCCGGTGGCGCAATATCCGACGATTGCGCCGCCAGCAATTTCCATTACCGCCATGTACCCCGGTGCTGACGCCGAAACGGTGCAGAACACCGTAACTCAGGTTATCGAACAGAATATGAACGGTATCGATCACCTGATGTACATGTCCTCAAATGGCGACTCCACCGGTACGGCAACCATTACGCTGACCTTCGAATCCGGTACCGATCCGGATATCGCCCAGGTTCAGGTTCAGAACAAGCTGGCGCTGGCGACGCCTCTGCTGCCGCAAGAAGTACAGCAGCAAGGGATTAGCGTTGAGAAAGCGTCCAGCAGCTTCCTGATGGTTGTCGGCGTCATTAACACCAACGGCACCATGAACCAGGACGATATTTCGGACTACGTGGCGGCCAACATGAAGGATCCGATTAGCCGTACCAGCGGCGTCGGCGACGTTCAGCTATTCGGTTCCCAGTATGCGATGCGTATCTGGATGGATCCAAACAAACTGAACAACTTCCAGCTTACGCCGGTGGATGTGATCAGCGCCCTGAAAGCGCAGAACGCCCAGGTGGCCGCGGGCCAGTTAGGCGGTACGCCGCCGGTGAAAGGCCAGCAGCTTAACGCCTCGATCATCGCGCAGACGCGTCTGACCAATACGGAAGAGTTTGGCAACATCCTGCTGAAGGTGAACCAGGACGGTTCCCAGGTTCGTCTGCGTGATGTCGCCAAAATTGAGCTGGGCGGCGAAAGCTATGACGTAGTGGCGAAGTTTAACGGCCAGCCGGCATCCGGTCTGGGTATTAAACTGGCTACCGGCGCGAACGCGCTGGATACCGCCAACGCTATTCGCGCTGAACTGGCGAAGATGGAGCCGTTTTTCCCGTCGGGGATGAAGATCGTTTACCCGTATGACACCACCCCGTTCGTGAAAATTTCTATTCACGAAGTGGTTAAAACGCTGGTGGAAGCGATCATCCTGGTGTTCCTGGTCATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCCACCATCGCGGTACCGGTGGTCCTGTTAGGCACCTTCGCGGTGCTGGCGGCGTTTGGCTTCTCGATAAACACCCTGACGATGTTCGGGATGGTGCTCGCCATCGGCCTGTTGGTGGATGACGCCATCGTGGTGGTAGAGAACGTCGAGCGCGTGATGGCGGAAGAGGGTCTGCCGCCGAAAGAAGCGACGCGTAAATCGATGGGACAGATTCAGGGCGCGCTGGTTGGTATCGCTATGGTGCTGTCGGCGGTATTTATCCCGATGGCGTTCTTCGGCGGCTCAACCGGGGCCATCTATCGCCAGTTCTCCATCACTATCGTTTCCGCGATGGCGCTGTCGGTACTGGTGGCGTTAATCCTGACGCCGGCGCTGTGCGCCACGATGCTGAAACCCATTCAGAAAGGCAGCCATGGCGCGACCACCGGCTTCTTCGGCTGGTTTAACCGCATGTTTGATAAGAGCACGCACCATTACACCGACAGCGTAGGCAACATTCTGCGCAGCACCGGTCGTTATCTGGTGCTGTATCTGATCATCGTGGTGGGTATGGCATGGCTGTTCGTCCGTCTGCCGAGCTCGTTCCTGCCGGACGAGGACCAGGGTGTATTCCTGAGTATGGCGCAGCTGCCTGCCGGCGCCACCCAGGAGCGTACGCAGAAAGTGCTGGATGAGATGACGAATTACTATCTCACCAAAGAGAAGGACAACGTGGAATCCGTGTTTGCGGTTAACGGCTTCGGTTTCGCCGGCCGCGGCCAGAACACCGGTATCGCGTTCGTTTCGCTGAAAGACTGGAGCCAGCGTCCGGGTGAGGAAAACAAAGTTGAAGCGATCACCGCGAGAGCAATGGGCTACTTCTCGCAGATTAAAGATGCGATGGTCTTCGCCTTTAACCTGCCGGCTATCGTTGAACTGGGTACCGCGACCGGCTTTGACTTCGAGCTGATTGACCAGGGCGGTCTGGGCCACGAAAAACTGACCCAGGCGCGTAACCAACTGTTTGGCATGGTGGCGCAGCATCCTGACGTGCTGACCGGCGTGCGCCCTAACGGTCTGGAAGATACACCGCAGTTTAAAATCGATATCGATCAGGAGAAAGCTCAGGCGCTGGGCGTCTCCATCAGCGACATTAACACCACGCTGGGCGCAGCCTGGGGCGGAAGCTATGTCAACGACTTTATCGACCGCGGCCGCGTGAAGAAAGTGTACATCATGTCCGAAGCGAAATACCGTATGCTGCCGGAAGATATCGGCAAGTGGTATGTTCGCGGCAGCGATGGTCAGATGGTGCCGTTCTCTGCTTTCTCGACCTCGCGTTGGGAATACGGTTCGCCGCGTCTGGAACGCTACAACGGTCTGCCGTCACTGGAAATCCTCGGTCAGGCCGCGCCAGGCAAGAGTACCGGTGAGGCGATGGCGCTGATGGAAGAGCTGGCGGGTAAACTGCCTTCCGGTATCGGCTACGACTGGACCGGGATGTCTTATCAGGAGCGACTGTCCGGCAACCAGGCCCCTGCCCTGTATGCCATCTCGCTGATTGTCGTCTTCCTGTGTCTGGCGGCGCTGTATGAGAGCTGGTCGATTCCGTTCTCGGTTATGCTGGTCGTCCCCTTGGGTGTGGTTGGTGCGCTGTTAGCCGCCACCTTCCGCGGGCTAACCAACGACGTTTACTTCCAGGTGGGTCTGCTGACCACCATCGGCCTGTCGGCGAAGAACGCAATATTGATCGTTGAATTCGCCAAAGACCTGATGGAGAAAGAGGGCAAAGGGCTGATTGAGGCGACGCTTGAAGCAGTACGTATGCGTCTACGTCCAATCCTGATGACATCTCTGGCGTTCATCCTCGGGGTAATGCCGCTAGTTATCAGCTCCGGCGCCGGCTCCGGTGCGCAGAACGCCGTCGGTACAGGCGTAATGGGCGGGATGGTGACCGCGACGATCCTGGCGATCTTCTTCGTGCCGGTGTTCTTTGTGGTGGTTCGTCGCCGCTTTAGCAAAAAATCGGAAGATATAGAGCACAGCCATCAGGTTGAGCATCATTAA	MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYPGADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDPDIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMNQDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNILLKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANALDTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIQKGSHGATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATILAIFFVPVFFVVVRRRFSKKSEDIEHSHQVEHH	MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH	99.90	gnl|BL_ORD_ID|1035|hsp_num:0	1104		
+NODE_6_length_262587_cov_42.4347_234 # 216120 # 217280 # 1 # ID=6_234;partial=00;start_type=TTG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.621	NODE_6_length_262587_cov_42.4347_234	216120	217280	+	Strict	500	690.263	Escherichia coli ampH beta-lactamase	85.71	3004612	protein homolog model	n/a	n/a	cephalosporin; penam	antibiotic inactivation	ampC-type beta-lactamase	TTGAAACGTAGTTTGCTCATTTTTGCTGCGCTGTGCGCGGCGTCGTGGACCTCGGTGCAGGCCGCACAGCCTACCGTTGACCCGGTTTTCGCCTCGGATGTGGTCGATCGTTACGCCAATCATATCTACTACGGCAGCGGCGCCACCGGCATGGCGCTGGTGGTTATCGATGGCAATCAGCGTGTTTTTCGCAGCTTTGGCGAAACCCGCCCGGGGAATAATCAGCACCCGCAGCTCGACTCGGTGATCCGTATCGCCTCCCTCAGCAAACTGATGACCAGCGAGATGCTGGTGAAGCTGCTCGACCAGGGGGTGGTGAAACTCAACGATCCGCTGAGTAAATACGCCCCGCCGGGCGCCCGGGTGCCTGACTGGCAGGGAAAACCAATCACCCTGGTGAATCTCGCGACCCATACCAGCGCCCTGCCGCGCGAGCAGCCTGGTGGCGCCGCTCATCGTCCGGTGTTTGTCTGGCCGACCCGCCAGCAGCGCTGGAACTGGCTCTCTACCGCGACCCTGAAAGCCGCGCCGGGCTCGCAGGCGGCCTACTCCAACCTGGCCTTCGATTTACTGGCAGACGCGCTCGCCACCGCCGCCGGCAAACCGTATCCGCAGCTGTTTGAAGAGCAGATCACCCGGCCGCTGGGGATGAAGGACACCACCTTTACCCCGTCACCGGATCAGTGCCAGCGGCTGATGATCCCGGAAAAAGGCGCCAGCCCATGCAACAACACCCTGGCGGCGATCGGCAGCGGCGGAGTCTACTCGACGCCGGGGGATATGATGCGCTGGATGCAGCAGTTCCTGTCATCCGATTTCTATACCCGCAGCCAGCAGGCCGACCGGATGCAGACGCTGATTTATCAGCGTAACCAGCTGACCCGGGTGATTGGTATGGACGTGCCGGGCCGCGCCGACGCGCTGGGCCTCGGCTGGGTGTATATGAAGCCGAAGAACGGCCATCCGGGGATTATTCAGAAAACCGGCGGCGGCGGCGGGTTTATCACCTATATGGCGATGAATCCGCAGGCTAACGTTGGCGCCTTTGTGGTGGTAACCCGCTCGCCGTTGACCCGCTTCAACAATATGAGCGATGGCATCAACGACCTGGTCAGCGAGCTGAGCGGCGCACAGCCCAACATGCAGACGGCCAGCCAGTAA	MKRSLLIFAALCAASWTSVQAAQPTVDPVFASDVVDRYANHIYYGSGATGMALVVIDGNQRVFRSFGETRPGNNQHPQLDSVIRIASLSKLMTSEMLVKLLDQGVVKLNDPLSKYAPPGARVPDWQGKPITLVNLATHTSALPREQPGGAAHRPVFVWPTRQQRWNWLSTATLKAAPGSQAAYSNLAFDLLADALATAAGKPYPQLFEEQITRPLGMKDTTFTPSPDQCQRLMIPEKGASPCNNTLAAIGSGGVYSTPGDMMRWMQQFLSSDFYTRSQQADRMQTLIYQRNQLTRVIGMDVPGRADALGLGWVYMKPKNGHPGIIQKTGGGGGFITYMAMNPQANVGAFVVVTRSPLTRFNNMSDGINDLVSELSGAQPNMQTASQ	MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS	100.26	gnl|BL_ORD_ID|2080|hsp_num:0	3307		
+NODE_8_length_247415_cov_40.5207_219 # 227800 # 229548 # -1 # ID=8_219;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.567	NODE_8_length_247415_cov_40.5207_219	227800	229548	-	Strict	1000	1126.69	msbA	92.78	3003950	protein homolog model	n/a	n/a	nitroimidazole antibiotic	antibiotic efflux	ATP-binding cassette (ABC) antibiotic efflux pump	ATGCAGAACGATAAAGATCTCTCCACGTGGCAGACCTTCCGCCGACTTTGGCCGATTATCGCGCCGTTTAAAGCCGGGCTAATCGTAGCGGCGGTGGCGTTGGTGCTTAACGCGGGCAGTGACACCTTCATGTTATCGCTTCTTAAACCGTTATTGGATGATGGTTTTGGTAAAACGGATCGCTCAGTGCTGCTATGGATGCCGCTGGTGGTTATCGGCCTGATGGTGCTGCGTGGGATCACCAGCTACATCTCGAGCTATTGTATTTCCTGGGTTTCCGGCAAAGTGGTGATGACCATGCGTCGTCGCCTGTTCGGCCACATGATGGGTATGCCGGTGGCCTTCTTTGACAAGCAGTCTACCGGAACGCTGCTGTCACGCATCACCTATGATTCTGAGCAGGTCGCCTCCTCTTCTTCCAGCGCGCTGATCACCGTGGTCCGCGAAGGAGCATCGATTATCGGTCTGTTCGTGATGATGTTCTATTACAGCTGGCAGCTGTCGCTGATCCTGATCGTACTGGCGCCGATTGTGTCGGTGGCGATCCGCGTGGTCTCCAAGCGTTTTCGCAATATCAGTAAGAATATGCAGAACACGATGGGGCAGGTCACCACCAGCGCCGAGCAGATGCTGAAAGGGCACAAAGAGGTGCTGATGTTTGGCGGCCAGGAAGTGGAAACCAAACGTTTTGATAAAGTCAGCAATAAAATGCGTCTGCAGGGGATGAAGATGGTTTCCGCCTCGTCTATCTCCGACCCGATCATTCAGCTTATCGCCTCCCTGGCGCTGGCCTTTGTCCTGTATGCCGCCAGCTTCCCGAGCGTGATGGACACCCTGACCGCCGGGACCATTACCGTGGTCTTCTCCTCGATGATTGCGCTGATGCGTCCGCTGAAGTCGCTGACCAACGTCAATGCCCAGTTCCAGCGCGGGATGGCGGCGTGCCAGACGCTGTTTGCGATCCTCGATTCCGAGCAGGAAAAAGACGAAGGTACGCGGGTCATTGAGCGGGCGAAAGGCAATCTCAAGTTCGAGAACGTCACCTTTACCTACCCGGGTCGCGAAGTGGCCGCGCTGCGCAATATCAATCTCGATATCCCGGAAGGGAAAACAGTGGCGCTGGTGGGGCGCTCAGGGTCGGGTAAATCGACCATTGCCAGCCTGATCACCCGCTTCTACGATGTCGACGAGGGGCAGATCCTGCTGGATGGCCACGACCTGCGCGAGTACAAGCTGAGCTCGCTGCGCGACCAGGTGGCGCTGGTTTCACAAAACGTGCATCTGTTCAACGATACCGTCGCCAACAATATCGCCTATGCCCGTACCGAAGAGTACAGCCGCGAGCAGATTGAAGAGGCCGCGCGCATGGCCTACGCCATGGATTTCATTAACAAGATGGATAATGGTCTGGATACCATCATCGGCGAGAATGGCGTGATGCTGTCCGGCGGCCAGCGCCAGCGTATTGCTATTGCCCGCGCGCTGCTGCGTAACAGCCCGATCCTGATCCTCGATGAAGCCACCTCGGCGCTGGATACCGAGTCCGAGCGTGCTATTCAGGCGGCGCTGGATGAGCTGCAGAAAAACCGTACCTCGCTGGTTATCGCTCACCGTCTGTCGACCATTGAGCAGGCTGATGAAATCGTGGTGGTTGAAGACGGGCGGATCGTGGAGCGCGGAACGCACCATGACCTGCTGGAGCATAAGGGCGTGTACGCCCAGCTGCATAAGATGCAATTCGGCGAATGA	MQNDKDLSTWQTFRRLWPIIAPFKAGLIVAAVALVLNAGSDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMVLRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSLILIVLAPIVSVAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLKFENVTFTYPGREVAALRNINLDIPEGKTVALVGRSGSGKSTIASLITRFYDVDEGQILLDGHDLREYKLSSLRDQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVMLSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGRIVERGTHHDLLEHKGVYAQLHKMQFGE	MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ	100.00	gnl|BL_ORD_ID|2249|hsp_num:0	2423		
+NODE_9_length_203843_cov_42.4911_20 # 15303 # 15935 # 1 # ID=9_20;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.518	NODE_9_length_203843_cov_42.4911_20	15303	15935	+	Strict	400	432.95	CRP	99.05	3000518	protein homolog model	n/a	n/a	macrolide antibiotic; fluoroquinolone antibiotic; penam	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGGTGCTTGGCAAACCGCAAACAGACCCTACCCTTGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCAAAGAGCACGCTGATCCACCAGGGTGAAAAAGCAGAAACGCTGTACTACATCGTTAAAGGCTCCGTGGCTGTACTCATCAAGGATGAAGAAGGTAAAGAGATGATCCTCTCCTACCTCAACCAGGGCGATTTCATCGGTGAATTAGGCCTGTTTGAAGAGGGTCAGGAACGTAGCGCCTGGGTACGGGCGAAAACCGCATGTGAAGTGGCCGAAATCTCTTATAAGAAATTCCGTCAGCTGATCCAGGTGAACCCGGACATTCTGATGCGTCTCTCTTCGCAAATGGCTCGCCGTCTGCAGGTCACGTCTGAGAAAGTGGGCAACCTGGCCTTCCTCGACGTGACGGGCCGTATCGCCCAGACGCTGCTGAACCTGGCGAAGCAACCGGATGCCATGACCCACCCGGACGGTATGCAAATTAAAATTACCCGCCAGGAAATTGGTCAGATCGTCGGCTGCTCTCGTGAAACCGTTGGTCGTATTTTGAAAATGCTGGAAGATCAGAACCTGATTTCCGCGCACGGTAAAACCATCGTCGTCTACGGCACCCGTTAA	MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR	MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR	100.00	gnl|BL_ORD_ID|818|hsp_num:0	869		
+NODE_9_length_203843_cov_42.4911_123 # 130217 # 131200 # -1 # ID=9_123;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.603	NODE_9_length_203843_cov_42.4911_123	130217	131200	-	Strict	550	577.785	PmrF	83.69	3003578	protein homolog model	n/a	n/a	peptide antibiotic	antibiotic target alteration	pmr phosphoethanolamine transferase	ATGCTTACTTACCCTCCCGTGAAGAAGGTCTCGGTGGTTATCCCGGTTTATAACGAACAGGATAGCCTGCCGGAACTGCTTCGTCGTACGGATGCCGCCTGCGCCACCCTGGGGCGGCAATATGAAATTCTGTTGATCGACGATGGCAGCAGCGACGATTCCGCGCGCATGCTCACCGAAGCCGCCGAGGCGGAAGGCAGCCACGTCGTCGCCGTGCTGTTAAACCGTAACTACGGCCAGCACTCGGCGATCATGGCCGGCTTCAGCCATGTAACCGGCGATCTGATTATTACCCTCGACGCCGACCTGCAAAACCCGCCGGAGGAGATCCCGCGGCTGGTGGCGAAGGCTGATGAAGGTTACGACGTGGTGGGCACCGTCCGCCAGAACCGTCAGGACAGCATCTTCCGTAAAACCGCGTCGAAGATGATCAACCGCCTGATCCAGCGCACCACCGGCAAAGCGATGGGCGACTACGGCTGCATGCTGCGCGCTTACCGCCGCCATATCATCGACGCCATGCTCAACTGCCATGAGCGCAGCACCTTTATCCCGATCCTGGCGAATACCTTCGCCCGGCGCGCGGTGGAGATCCCGGTGATGCACGCCGAGCGCGAATTCGGCGACTCCAAATACAGCTTTATGCGCCTGATCAACCTGATGTACGACCTGGTGACCTGTCTGACCACCACGCCGCTGCGTCTGCTCAGCATTTTCGGCAGCGTGATTGCCCTGCTGGGCTTCGCCTTCGGCCTGCTGCTGGTGGTGCTGCGTCTGGCCTTTGGCCCGCAGTGGGCGGCGGAAGGGGTGTTTATGCTCTTCGCCGTGCTGTTCATGTTCATCGGCGCCCAGTTTGTCGGTATGGGCCTGCTCGGGGAGTATATCGGCCGCATCTATAACGACGTGCGCGCCCGCCCCCGCTACTTTATTCAACGTGTTGTTCGCCAGCCGGAAACGGCATCTAAAGAGGAAGATCGTTCATGA	MLTYPPVKKVSVVIPVYNEQDSLPELLRRTDAACATLGRQYEILLIDDGSSDDSARMLTEAAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSIFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHERSTFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSIFGSVIALLGFAFGLLLVVLRLAFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYNDVRARPRYFIQRVVRQPETASKEEDRS	MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE	101.55	gnl|BL_ORD_ID|1977|hsp_num:0	2014		
+NODE_11_length_157792_cov_39.2115_112 # 108413 # 108787 # 1 # ID=11_112;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.509	NODE_11_length_157792_cov_39.2115_112	108413	108787	+	Strict	230	243.432	marA	92.74	3000263	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan; penem	antibiotic efflux; reduced permeability to antibiotic	resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams	ATGTCCAGACGTAATAATGACGCCATCACTATCCATAGTATTTTGTCGTGGATCGAGGATAACCTGGAATCGCCCCTGTCGCTGGAAAAAGTGTCTGAGCGCTCCGGTTACTCTAAGTGGCACCTGCAACGTATGTTTAAGAAAGAGACCGGCCATTCCCTCGGCCAGTACATCCGCAGCCGCAAGCTGACGGAGATTGCGCAGAAGCTCAAGCAGAGTAATGAGCCAATCCTGTACCTGGCGGAACGCTATGGTTTCGAGTCGCAGCAGACCCTGACGCGAACGTTCAAGAACTATTTCGATGTTCCGCCCCACAAGTATCGCATAACGAATGTACCTGGCGAATCCCGCTATCTACATCCGCTAAATAACTGA	MSRRNNDAITIHSILSWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKLTEIAQKLKQSNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNVPGESRYLHPLNN	MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS	97.64	gnl|BL_ORD_ID|1815|hsp_num:0	1922		
+NODE_11_length_157792_cov_39.2115_132 # 128890 # 129750 # 1 # ID=11_132;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.628	NODE_11_length_157792_cov_39.2115_132	128890	129750	+	Perfect	550	580.867	SHV-11	100.0	3001070	protein homolog model	n/a	n/a	carbapenem; cephalosporin; penam	antibiotic inactivation	SHV beta-lactamase	ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGTATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA	MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR	MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR	100.00	gnl|BL_ORD_ID|539|hsp_num:0	578		
+NODE_19_length_86672_cov_43.8582_38 # 39587 # 39811 # -1 # ID=19_38;partial=00;start_type=ATG;rbs_motif=AGxAG;rbs_spacer=5-10bp;gc_cont=0.551	NODE_19_length_86672_cov_43.8582_38 	39587	39811	-	Strict	600	21.557	CBP-1	100.0	3004764	protein homolog model	n/a	n/a	penam	antibiotic inactivation	CBP beta-lactamase	ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA	MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY	MKKIVNSKLKVNKFKMCIFISILIFSLTGCGNVENKTSENTKPEIQYNSAFSKIESDYGVKLGVYAFDTETNKEVTYNADKRFAYCSTFKSLISGAILQKYSSDQLKQVIKYSPKDVLSYAPVTKNHVDKGMTIEELCDAAVRFSDNTAANLLINLIGGPNGFKSALNQLGDTVTEPARIEPELNVATPGDNRDTSTPRQLSIDLKEYTTGNILSDDKKKILINWMSGNATGDKLIRAGAPKDWMVSDKSGTGSYGTRNDIAIVIPPNKKPIFIAILSSKNDKDAKYDDKTISEASKIVFDYFINTRK	24.03	gnl|BL_ORD_ID|2592|hsp_num:0	3567	True	loose hit with at least 95 percent identity pushed strict
+NODE_21_length_66123_cov_41.3566_52 # 60858 # 62090 # 1 # ID=21_52;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.603	NODE_21_length_66123_cov_41.3566_52	60858	62090	+	Strict	700	706.057	Escherichia coli mdfA	85.61	3001328	protein homolog model	n/a	n/a	tetracycline antibiotic; benzalkonium chloride; rhodamine	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGCAAAATTATTCGCTTTCAGGCCGCCGCCTCGGAAGGCAGGCGCTGTTGTTCCCGTTATGTCTGGTGCTGTACGAGTTTTCCACTTATATCGGCAACGATATGATTCAGCCGGGCATGTTAGCCGTGGTGCAGGAATTTCAGGTGGGCAACGAATGGGTACCTACTTCAATGACTGCCTATCTGGCAGGCGGCATGTTTTTACAGTGGCTGCTGGGGCCGCTGTCGGATCGTATTGGCCGCCGTCCGGTGATGTTGACCGGCGTAGTATGGTTTATCGTCACCTGCCTGGCGACGCTGCTGGCGCAGACCATTGAGCAGTTTACCCTGCTGCGCTTCCTGCAGGGGATCAGCCTGTGCTTTATCGGCGCGGTGGGCTATGCGGCGATACAGGAGTCCTTTGAGGAGGCGGTGTGTATCAAAATCACCGCCCTGATGGCTAACGTGGCGCTGATTGCCCCGCTGCTGGGGCCGCTGGTGGGCGCCGCCTGGGTGCATGTCCTGCCGTGGGAGATGATGTTTGTCCTGTTCGCCGTGCTGGCGGCCATCTCGTTCTTCGGCCTGCAGCGGGCGATGCCGGAGACCGCGACGCGGCTGGGCGAAAAGCTGTCGGTGAAAGAGCTGGGCCGCGACTATCGGCTGGTGCTGAAGAACCTGCGCTTCGTCGCCGGCGCGCTGGCCACTGGCTTTGTCAGCCTGCCGCTGCTGGCGTGGATTGCCCAGTCGCCGGTGATTATTATCAGCGGCGAACAGGCCACCAGCTATGAGTACGGCATGCTGCAGGTGCCGATTTTCGGGGCGCTGATTGCCGGCAACCTGGTGCTGGCGCGCCTGACTGCGCGTCGGACCGTGCGCTCGCTGATTATCATGGGCGGTTGGCCGATCATGTTTGGCCTGATCCTCTCTGCGGCGGCGACCGTGGTCTCTTCCCACGCTTATCTGTGGATGACGGCCGGTCTGAGCTTCTACGCCTTCGGGATTGGCCTCGCGAACGCCGGCCTGGTGCGTTTAACCCTGTTCGCCAGCGAGATGAGTAAAGGCACGGTCTCGGCGGCGATGGGAATGCTGCAGATGCTGATCTTCACCGTCGGCATCGAGCTCAGCAAACATGCTTACGAGCTGGGCGGCAACGGGCTGTTCAGCCTGTTTAACCTGCTGGGTGGGGTACTATGGCTGGGGCTGATGATTTACTTTCTGAAAGATAAAAGCGTCGGCAATTCGCAGCAGGGGTAG	MQNYSLSGRRLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVQEFQVGNEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFIVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEMMFVLFAVLAAISFFGLQRAMPETATRLGEKLSVKELGRDYRLVLKNLRFVAGALATGFVSLPLLAWIAQSPVIIISGEQATSYEYGMLQVPIFGALIAGNLVLARLTARRTVRSLIIMGGWPIMFGLILSAAATVVSSHAYLWMTAGLSFYAFGIGLANAGLVRLTLFASEMSKGTVSAAMGMLQMLIFTVGIELSKHAYELGGNGLFSLFNLLGGVLWLGLMIYFLKDKSVGNSQQG	MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMRQPGMLENVEQYQAGIEWVPTSMNAYLAGGMFIQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLHGISLCFIGAVGYDAIQESFEEAVCIKITALMANVALIAPLLGPLVGASWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFLSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASVMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILLLSLMVIFLKDKQMGNSHEG	100.00	gnl|BL_ORD_ID|2494|hsp_num:0	37		
+NODE_27_length_37761_cov_37.6839_21 # 25311 # 25673 # 1 # ID=27_21;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.471	NODE_27_length_37761_cov_37.6839_21	25311	25673	+	Strict	150	223.402	Klebsiella pneumoniae KpnE	99.17	3004580	protein homolog model	n/a	n/a	macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGTTTTATTGGATTTTATTAGCTTTAGCAATTATTGCTGAAATTACCGGCACCTTGTCTATGAAATGGGCAAGCGTGAGCGGCGGGCACACCGGCTTTATTTTAATGCTGGCCATGATTGCCCTGTCATATATTTTTCTTGCCTTTGCGGTTAAAAAGATTGCCCTCGGTGTGGCCTATGCGTTGTGGGAAGGGATCGGTATTTTACTGATTACCCTGTTCAGCGTGCTGCTGTTTGATGAGAGTCTGTCCCTGCTGAAAATAGCCGGCTTGACCACCCTGGTGATAGGGATCGTCTTAATTAAGTCCGGCACCCAGAAAAAAGCGTCTTCCAAGCAGGAGGTGGCCCATGCAGCAGTTTGA	MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSKQEVAHAAV	MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV	100.00	gnl|BL_ORD_ID|2771|hsp_num:0	3283		
+NODE_27_length_37761_cov_37.6839_22 # 25660 # 25989 # 1 # ID=27_22;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.588	NODE_27_length_37761_cov_37.6839_22	25660	25989	+	Perfect	150	206.453	Klebsiella pneumoniae KpnF	100.0	3004583	protein homolog model	n/a	n/a	macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	ATGCAGCAGTTTGAGTGGATCCACGCCGCCTGGCTGGCAATCGCCATTGTGCTGGAAATTATTGCCAACGTCTTTTTGAAGTTTTCCGACGGCTTCCGCCGCAAGATCTACGGCATCCTGTCCCTGGCGGCAGTATTGGGCGCGTTCAGCGCCCTGTCGCAGGCGGTTAAAGGGATCGATCTCTCGGTCGCCTATGCGCTGTGGGGCGGCTTCGGTATCGCGGCGACCATCGCCGCCGGCTGGGTGCTGTTTGGTCAGCGTCTGAATAACAAAGGCTGGGCGGGGGTTATCCTGCTGGTAGCCGGCATGGTGTTAATTAAACTCGCCTGA	MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA	MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA	100.00	gnl|BL_ORD_ID|2774|hsp_num:0	3286		
+NODE_39_length_11164_cov_23.0187_6 # 4569 # 5429 # 1 # ID=39_6;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.598	NODE_39_length_11164_cov_23.0187_6	4569	5429	+	Perfect	570	586.645	AAC(3)-IId	100.0	3004623	protein homolog model	n/a	n/a	aminoglycoside antibiotic	antibiotic inactivation	AAC(3)	ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCAGGTTAG	MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG	MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG	100.00	gnl|BL_ORD_ID|2170|hsp_num:0	3322		
+NODE_40_length_7360_cov_24.8738_6 # 6358 # 7203 # -1 # ID=40_6;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.410	NODE_40_length_7360_cov_24.8738_6	6358	7203	-	Perfect	500	578.941	rmtC	100.0	3000861	protein homolog model	n/a	n/a	aminoglycoside antibiotic	antibiotic target alteration	16S rRNA methyltransferase (G1405)	ATGAAAACCAACGATAATTATATCGAAGAAGTAACAGCCAAAGTACTCACAAGTGGTAAATACTCCACACTTTATCCACCAACTGTACGACGTGTAACTGAGAGGCTTTTCGATCGATACCCTCCCAAGCAGCTAGAGAAGGAGGTTCGCAAGAAATTGCATCAAGCATATGGTGCTTATATTGGTGGGATCGATGGGAAAAGGTTGGAGAAGAAGATTGAGAAGATAATTCATGAGATACCAAATCCAACTACGGATGAAGCAACTCGTACGGAGTGGGAAAAAGAGATCTGCCTGAAAATATTGAACTTGCACACTTCAACAAATGAGCGAACGGTGGCTTACGATGAGCTTTACCAAAAGATCTTTGAGGTAACAGGGGTTCCAACAAGTATCACCGATGCAGGTTGCGCTTTGAATCCATTTTCTTTTCCATTCTTTACGGAGGCTGGCATGCTTGGGCAATACATAGGTTTCGATCTTGATAAAGGTATGATCGAAGCGATCGAACACTCGTTGAGAACGCTTAACGCCCCAGAGGGTATTGTTGTCAAACAGGGAGATATATTATCCGATCCGTCAGGCGAGAGTGATCTTCTACTTATGTTCAAGCTATATACTCTACTCGATCGGCAGGAAGAGGCCTCTGGTTTGAAAATTCTTCAAGAGTGGAAATACAAAAATGCTGTGATCTCTTTTCCTATTAAAACTATAAGTGGGAGAGATGTTGGGATGGAAGAGAATTACACTGTTAAGTTCGAGAATGATCTTGTTGGGTCAGATCTGAGAATCATGCAAAAATTGAAATTAGGAAACGAGATGTATTTTATCGTATCGAGATTGTAA	MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL	MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL	100.00	gnl|BL_ORD_ID|1448|hsp_num:0	1540		
+NODE_44_length_4295_cov_23.2123_1 # 301 # 1113 # 1 # ID=44_1;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.615	NODE_44_length_4295_cov_23.2123_1	301	1113	+	Perfect	500	555.829	NDM-1	100.0	3000589	protein homolog model	n/a	n/a	carbapenem; cephalosporin; cephamycin; penam	antibiotic inactivation	NDM beta-lactamase	ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA	MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR	MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR	100.00	gnl|BL_ORD_ID|731|hsp_num:0	783		
+NODE_44_length_4295_cov_23.2123_2 # 1222 # 1482 # 1 # ID=44_2;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.621	NODE_44_length_4295_cov_23.2123_2 	1222	1482	+	Strict	200	177.563	BRP(MBL)	100.0	3001205	protein homolog model	n/a	n/a	glycopeptide antibiotic	antibiotic inactivation	Bleomycin resistant protein	ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA	MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD	MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD	71.07	gnl|BL_ORD_ID|2418|hsp_num:0	255	True	loose hit with at least 95 percent identity pushed strict
+NODE_44_length_4295_cov_23.2123_3 # 1846 # 2862 # -1 # ID=44_3;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.571	NODE_44_length_4295_cov_23.2123_3 	1846	2862	-	Strict	700	538.88	DHA-7	100.0	3002136	protein homolog model	n/a	n/a	cephalosporin; cephamycin	antibiotic inactivation	DHA beta-lactamase	ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG	MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA	MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGSGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE	89.18	gnl|BL_ORD_ID|582|hsp_num:0	622	True	loose hit with at least 95 percent identity pushed strict
+NODE_47_length_3813_cov_27.9457_4 # 2763 # 3638 # -1 # ID=47_4;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.550	NODE_47_length_3813_cov_27.9457_4	2763	3638	-	Perfect	500	593.578	CTX-M-15	100.0	3001878	protein homolog model	n/a	n/a	cephalosporin	antibiotic inactivation	CTX-M beta-lactamase	ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA	MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL	MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL	100.00	gnl|BL_ORD_ID|1919|hsp_num:0	2035		
+NODE_51_length_1731_cov_22.5767_1 # 196 # 1026 # 1 # ID=51_1;partial=00;start_type=ATG;rbs_motif=ATA;rbs_spacer=6bp;gc_cont=0.345	NODE_51_length_1731_cov_22.5767_1	196	1026	+	Perfect	500	564.303	OXA-1	100.0	3001396	protein homolog model	n/a	n/a	cephalosporin; penam	antibiotic inactivation	OXA beta-lactamase	ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA	MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL	MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL	100.00	gnl|BL_ORD_ID|1846|hsp_num:0	1952		
+NODE_51_length_1731_cov_22.5767_2 # 1164 # 1712 # 1 # ID=51_2;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.494	NODE_51_length_1731_cov_22.5767_2 	1164	1712	+	Strict	350	308.145	catB3	100.0	3002676	protein homolog model	n/a	n/a	phenicol antibiotic	antibiotic inactivation	chloramphenicol acetyltransferase (CAT)	ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA	MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP	MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKKIKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV	86.67	gnl|BL_ORD_ID|134|hsp_num:0	150	True	loose hit with at least 95 percent identity pushed strict
+NODE_54_length_1272_cov_25.1921_2 # 1130 # 1270 # 1 # ID=54_2;partial=01;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.496	NODE_54_length_1272_cov_25.1921_2 	1130	1270	+	Strict	275	91.2781	AAC(6')-Ib-cr	95.45	3002547	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; aminoglycoside antibiotic	antibiotic inactivation	AAC(6')	ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA	MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA	MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA	23.62	gnl|BL_ORD_ID|1582|hsp_num:0	1678	True	loose hit with at least 95 percent identity pushed strict
+NODE_57_length_1134_cov_34.8908_1 # 25 # 864 # -1 # ID=57_1;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.615	NODE_57_length_1134_cov_34.8908_1	25	864	-	Perfect	500	553.132	sul1	100.0	3000410	protein homolog model	n/a	n/a	sulfonamide antibiotic	antibiotic target replacement	sulfonamide resistant sul	ATGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTCGATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGAGTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTATCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATGCACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGCGTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCTGAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGCACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGGGTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTAGATCCGGGGATGGGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAGCTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGCGCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCACGCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCAATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTAGATCATGCCTAG	MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA	MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA	100.00	gnl|BL_ORD_ID|1003|hsp_num:0	1070		
+NODE_69_length_625_cov_55.4398_1 # 63 # 623 # -1 # ID=69_1;partial=01;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.542	NODE_69_length_625_cov_55.4398_1	63	623	-	Strict	275	385.185	AAC(6')-Ib10	100.0	3002581	protein homolog model	n/a	n/a	aminoglycoside antibiotic	antibiotic inactivation	AAC(6')	AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA	SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA	MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA	91.63	gnl|BL_ORD_ID|1285|hsp_num:0	1370		
+NODE_185_length_335_cov_33.8077_1 # 172 # 333 # 1 # ID=185_1;partial=01;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.494	NODE_185_length_335_cov_33.8077_1 	172	333	+	Strict	275	115.931	AAC(6')-Ib-cr	100.0	3002547	protein homolog model	n/a	n/a	fluoroquinolone antibiotic; aminoglycoside antibiotic	antibiotic inactivation	AAC(6')	ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA	MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA	MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA	27.14	gnl|BL_ORD_ID|1582|hsp_num:0	1678	True	loose hit with at least 95 percent identity pushed strict
+NODE_1_length_803036_cov_42.265_543 # 550760 # 553018 # -1 # ID=1_543;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.593	NODE_1_length_803036_cov_42.265_543 	550760	553018	-	Strict	1400	1470.29	Escherichia coli parC conferring resistance to fluoroquinolone	94.41	3003308	protein variant model	S80I	n/a	fluoroquinolone antibiotic	antibiotic target alteration	fluoroquinolone resistant parC	ATGAGCGATATGGCAGAGCGCCTTGCGCTGCATGAATTTACGGAAAATGCTTACCTGAACTACTCCATGTACGTGATCATGGACAGGGCATTACCGTTTATTGGCGATGGCTTAAAACCGGTCCAGCGTCGCATCGTCTATGCGATGTCCGAGCTGGGGCTGAACGCCAGCGCGAAATTCAAAAAGTCCGCCCGCACCGTCGGCGACGTGTTGGGTAAATATCACCCGCACGGCGACATCGCCTGCTATGAAGCGATGGTGCTGATGGCGCAGCCGTTCTCTTACCGCTATCCGCTGGTGGATGGTCAGGGAAACTGGGGGGCGCCGGACGATCCCAAATCTTTCGCCGCCATGCGTTACACCGAATCCCGCCTGTCGAAGTATGCCGAGCTGCTGCTCAGCGAGCTGGGGCAGGGGACGGTCGACTGGGTGCCAAACTTTGACGGCACGCTGCAGGAGCCGAAAATGCTGCCAGCGCGTCTGCCGAACATCCTGCTGAACGGCACCACCGGCATCGCGGTAGGCATGGCGACCGATATTCCTCCGCACAACCTGCGGGAAGTGGCCAAAGCGGCGATTACGCTGATTGAGCAGCCGAAAACCACCCTCGACGAACTGCTGGATATCGTACAGGGGCCGGATTTCCCGACCGAGGCGGAGATCATCACCTCGCGGGCGGAAATTCGCAAAATCTACCAGAACGGGCGCGGCTCAGTGCGCATGCGTGCGGTGTGGAGTAAAGAGGACGGCGCGGTGGTGATCAGTGCGCTGCCGCATCAGGTCTCCGGCGCCAAAGTGCTGGAGCAGATTGCGGCGCAGATGCGCAATAAAAAGCTGCCGATGGTTGACGATCTGCGCGACGAATCGGACCACGAAAACCCGACCCGTCTGGTGATTGTCCCGCGCTCCAACCGGGTGGATATGGAACAGGTGATGAACCACCTGTTCGCCACCACCGATCTGGAGAAGAGCTACCGCATCAACCTCAATATGATCGGCCTTGACGGCCGCCCGGCGGTGAAAAACCTGCTGGAGATCCTCAGCGAGTGGCTGGTGTTCCGTCGCGATACCGTGCGTCGCCGTCTAAACCATCGGTTAGAGAAAGTGCTGAAGCGCCTGCATATCCTCGAAGGTTTGCTGGTGGCGTTTCTTAATATCGATGAAGTGATTGAGATCATCCGCACTGAAGATGAACCGAAGCCGGCCCTGATGTCGCGCTTTGGCATCAGCGAAACCCAGGCGGAAGCGATTCTGGAATTAAAACTGCGCCACCTCGCCAAACTGGAAGAGATGAAGATCCGCGGCGAGCAGAGCGAGCTGGAAAAAGAGCGCGACCAGCTGCAGGCGATTCTGGCGTCTGAACGTAAGATGAACAACCTGCTGAAAAAAGAGCTGCAGGCCGATGCCGATGCCTTCGGCGACGACCGTCGCTCGCCGCTTCACGAGCGTGAAGAAGCGAAAGCGATGAGCGAGCATGACATGCTGCCGTCTGAGCCGGTGACTATCGTTCTGTCGCAGATGGGCTGGGTGCGCAGCGCCAAAGGACACGACATTGACGCCCAGGGCTTGAGCTATAAGGCGGGCGACAGCTGGAAAGCCTCGGCGAAGGGCAAGAGCAACCAGCCGGTGGTGTTTATCGATACCACCGGACGCAGCTATGCCATCGATCCGATTACTCTGCCTTCCGCGCGTGGCCAGGGTGAACCGCTTACCGGCAAACTGACCCTGCCGCCGGGCGCGACCGTGGAGCATATGCTAATGGAAAGCGACGATCAGAAACTGCTGATGGCTTCCGACGCGGGCTACGGTTTCGTCTGTACCTTCAACGATCTGGTGGCGCGCAACCGTGCCGGTAAAGCGCTAATCACCCTGCCTGACAACGCGCACGTGATGCCGCCGCTGGTGATTGAGGATGAGTCCGATATGCTGCTGGCCATCACCGCCGCCGGGCGGATGCTGATGTTCCCGGTCAGCGATCTGCCGCAGCTGTCGAAAGGCAAGGGCAACAAAATTATCAGCATTCCGGCGGCGGAAGCCGCAGCCGGCCAGGACGGTCTGGCACATCTGTTTGTTCTGCCGCCGCAGAGTACGCTGACCATTCACGTCGGCAAACGGAAGATCAAACTGCGTCCGGAAGAGCTGCAAAAAGTCACCGGCGAGCGCGGCCGCCGCGGTTCGCTGATGCGCGGGCTGCAGAAAATTGACCGCGTGGAAATTGACTCGCCGCGTCGTGCCGCGGCAGGCGATAGCGAAGAGTAA	MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDIACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSPLHEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAQGLSYKAGDSWKASAKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNKIISIPAAEAAAGQDGLAHLFVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGSLMRGLQKIDRVEIDSPRRAAAGDSEE	MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE	100.00	gnl|BL_ORD_ID|2055|hsp_num:0	1450		
+NODE_3_length_454317_cov_40.2449_130 # 161019 # 163652 # -1 # ID=3_130;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.584	NODE_3_length_454317_cov_40.2449_130 	161019	163652	-	Strict	1500	1702.95	Salmonella enterica gyrA with mutation conferring resistance to triclosan	96.08	3004334	protein variant model	S83F	S83F:2403, S83F:2851	triclosan	antibiotic target alteration	triclosan resistant gyrA	ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA	MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE	MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE	99.89	gnl|BL_ORD_ID|2531|hsp_num:0	2850		
+NODE_4_length_367278_cov_42.3139_202 # 219948 # 221714 # 1 # ID=4_202;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.564	NODE_4_length_367278_cov_42.3139_202 	219948	221714	+	Strict	500	593.964	Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics	52.2	3004446	protein variant model	D350N, S357N	n/a	cephalosporin; cephamycin; penam	antibiotic target alteration	Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics	ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGCGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAACCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGGTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAAAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTGCGTAAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTGCAGGCGCTGGTCTATCGCGAGCTAAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTAGATGTTAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACCGACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGTGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAAGTTGATCCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGCGGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA	MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS	MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN	96.39	gnl|BL_ORD_ID|2567|hsp_num:0	2886		
+NODE_15_length_100593_cov_44.6763_85 # 89219 # 90610 # 1 # ID=15_85;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.585	NODE_15_length_100593_cov_44.6763_85 	89219	90610	+	Strict	850	864.374	Escherichia coli UhpT with mutation conferring resistance to fosfomycin	95.03	3003890	protein variant model	E350Q	n/a	fosfomycin	antibiotic target alteration	UhpT	ATGCTGGCCTTTCTGAATCAGGTGCGCAAGCCGACCTTGGATCTGCCGCTCGATGTGCGGCGCAAAATGTGGTTCAAACCTTTCATGCAGTCCTATCTGGTGGTTTTCATCGGCTACCTGACCATGTACTTGATCCGCAAGAACTTTAACATCGCGCAGAACGACATGATCTCCACCTACGGGCTGAGCATGACCCAGCTGGGGATGATTGGCCTGGGCTTCTCCATCACCTACGGCGTGGGCAAGACGCTGGTCTCTTATTATGCCGACGGCAAAAACACCAAGCAGTTCCTGCCGTTTATGCTGATCCTCTCCGCCATCTGTATGCTGGGCTTTAGCGCCAGCATGGGGGCGGGTTCTACCAGCCTGTTCCTGATGATCGCCTTCTATGCGCTGAGCGGTTTCTTCCAGAGCACCGGCGGCTCGTGCAGCTATTCCACCATCACCAAGTGGACGCCCAGACGCAAACGCGGCACTTTCCTCGGCTTCTGGAATATCTCCCACAACCTCGGCGGCGCGGGCGCGGCGGGCGTGGCGCTGTTTGGCGCCAACTATCTGTTCGACGGCCATGTGATCGGCATGTTTATCTTCCCGTCGATTATTGCGCTGATCGTTGGCTTTATCGGCCTGCGCTACGGTAGCGACTCTCCGGAATCCTACGGCCTCGGCACGGCGGAAGAGCTGTTTGGCGAAGCGATCAGCGAAGAGGACAAAGAGACCGAAGAAAATGCGATGACCAAGTGGCAGATCTTTGTTGAGTACGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCTCCAACATCTTCCTCTACGTGGTGCGTATCGGTATCGATCAGTGGTCCACCGTGTACGCCTTCCAGGAGCTGAAGCTGTCGAAAGAGGTGGCGATTCAGGGCTTTACCCTGTTTGAGGTCGGCGCGCTGGTCGGCACGCTGCTGTGGGGCTGGCTGTCGGATCTGGCCAACGGCCGCCGCGCGCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACCCTCGGGGTTTACCAACACGCCAGCAACCAGTACGTCTATCTGGCCTCGTTATTTGCGCTGGGCTTCCTGGTGTTTGGTCCGCAGCTGTTGATCGGCGTCGCCGCCGTCGGTTTCGTACCGAAAAAAGCGATCGGCGCCGCCGATGGGATCAAGGGCACCTTCGCCTATCTGATCGGCGATAGCTTCGCCAAACTGGGTCTCGGGATGATCGCCGACGGCACCCCGGTCTTCGGCCTGACCGGCTGGGCCGGCACCTTTGCGGCGCTGGACGCCGCCGCCGTCGGCTGTATCTGCCTGATGGCCATCGTGGCTATCTTTGAAGAGCGTAAAATTCGCCGCGAGAAAAAGAACCGTATTTTGCAGACCGCCTGA	MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA	MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA	100.00	gnl|BL_ORD_ID|2191|hsp_num:0	2373		
+NODE_59_length_1013_cov_103.874_1 # 1 # 1011 # 1 # ID=59_1;partial=11;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.547	NODE_59_length_1013_cov_103.874_1 	1	1011	+	Strict	700	676.396	Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin	98.22	3003369	protein variant model	R234F	n/a	elfamycin antibiotic	antibiotic target alteration	elfamycin resistant EF-Tu	GCTCGCGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACCTCTCACGTTGAATATGACACCCCGACTCGCCACTACGCGCACGTAGACTGCCCGGGCCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCGCAGATGGACGGCGCGATCCTGGTTGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAGATGGAAGTTCGTGAACTGCTGTCTCAGTACGATTTCCCGGGCGACGACACCCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCATCGAACTGGCTGGCCACCTGGATACCTATATCCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCTGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAGCGCGGTATCATCAAAGTAGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAAACCGCGAAAACCACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAACCCGCACACCAAGTTCGAATCTGAAGTGTACATCCTGTCCAAAGATGAAGGCGGCCGTCACACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGCACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGC	ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGHLDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTINPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG	MLSPEGESTIVRNIAVSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG	82.40	gnl|BL_ORD_ID|2022|hsp_num:0	2158	True	loose hit with at least 95 percent identity pushed strict
+NODE_11_length_157792_cov_39.2115_111 # 107958 # 108392 # 1 # ID=11_111;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.545	NODE_11_length_157792_cov_39.2115_111	107958	108392	+	Strict	210	251.906	Escherichia coli marR mutant conferring antibiotic resistance	83.33	3003378	protein overexpression model	n/a	n/a	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan	antibiotic target alteration; antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGAAAAGTACCAGCGACCTGTTTAATGAAATGATCCCGCTGGGTCGCTTGATCCAGATGGTTAACCAGAAAAAAGATCGCCTGCTCAATGACTACCTCTCACCTATGGATATTACCGCGACCCAGTTTCGCGTGCTCTGCTCCATTCGTTGCGAAGTATGTATTACCCCCGTTGAGCTGAAAACCGTGCTTTCCGTCGACCCGGGCGCAATGACGCGCATGCTCGACCGCCTGGCGTGCAAAGGCTGGATTAAACGGTTACCCAACCCCGCTGACAAGCGCGGCGTGCTGGTGCAGTTGACGCCGGACGGCGCAGCCCTTTGCGAGCAGTGTCATCAGGTTGTGGGTCAGAAGTTACACCAGGAGTTAACGAAAAATCTGTCGGCGGACGAAGTCGCCATGCTTGAGCAACTGCTCAAGAAGGTCCTGCCGTAA	MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLACKGWIKRLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP	MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP	100.00	gnl|BL_ORD_ID|2040|hsp_num:0	431		
+NODE_152_length_397_cov_0.740741_1 # 1 # 270 # -1 # ID=152_1;partial=10;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.637	NODE_152_length_397_cov_0.740741_1 	1	270	-	Strict	310	182.956	Type B NfxB	100.0	3004060	protein overexpression model	n/a	n/a	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC	MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH	MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS	48.13	gnl|BL_ORD_ID|2412|hsp_num:0	2693	True	loose hit with at least 95 percent identity pushed strict
diff -r 000000000000 -r d2590ecc4189 test-data/summary.json
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/summary.json	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,1 @@
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(G1405)","reference_database_id":"CARD","reference_database_version":"card_v1","reference_accession":3000861,"analysis_software_name":"rgi","analysis_software_version":"rgi_v1","sequence_identity":100.0,"input_sequence_id":"NODE_40_length_7360_cov_24.8738_6","input_protein_start":null,"input_protein_stop":null,"input_gene_start":6358,"input_gene_stop":7203,"reference_protein_start":null,"reference_protein_stop":null,"reference_gene_start":null,"reference_gene_stop":null,"strand_orientation":"-","coverage_depth":null,"coverage_percentage":100.0,"coverage_ratio":null,"reference_gene_length":null,"reference_protein_length":null,"input_gene_length":null,"input_protein_length":null,"drug_class":"aminoglycoside antibiotic","antimicrobial_agent":null,"resistance_mechanism":"antibiotic target alteration"},{"input_file_name":"rgi_report","gene_symbol":"sul1","gene_name":"sulfonamide resistant sul","reference_database_id":"CARD","reference_database_version":"card_v1","reference_accession":3000410,"analysis_software_name":"rgi","analysis_software_version":"rgi_v1","sequence_identity":100.0,"input_sequence_id":"NODE_57_length_1134_cov_34.8908_1","input_protein_start":"","input_protein_stop":"","input_gene_start":25,"input_gene_stop":864,"reference_protein_start":"","reference_protein_stop":"","reference_gene_start":"","reference_gene_stop":"","strand_orientation":"-","coverage_depth":"","coverage_percentage":100.0,"coverage_ratio":"","reference_gene_length":"","reference_protein_length":"","input_gene_length":"","input_protein_length":"","drug_class":"sulfonamide antibiotic","antimicrobial_agent":"","resistance_mechanism":"antibiotic target replacement"},{"input_file_name":"rgi_report","gene_symbol":"sul1","gene_name":"sulfonamide resistant sul","reference_database_id":"CARD","reference_database_version":"card_v1","reference_accession":3000410,"analysis_software_name":"rgi","analysis_software_version":"rgi_v1","sequence_identity":100.0,"input_sequence_id":"NODE_57_length_1134_cov_34.8908_1","input_protein_start":null,"input_protein_stop":null,"input_gene_start":25,"input_gene_stop":864,"reference_protein_start":null,"reference_protein_stop":null,"reference_gene_start":null,"reference_gene_stop":null,"strand_orientation":"-","coverage_depth":null,"coverage_percentage":100.0,"coverage_ratio":null,"reference_gene_length":null,"reference_protein_length":null,"input_gene_length":null,"input_protein_length":null,"drug_class":"sulfonamide antibiotic","antimicrobial_agent":null,"resistance_mechanism":"antibiotic target replacement"}]
\ No newline at end of file
diff -r 000000000000 -r d2590ecc4189 test-data/summary.tsv
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/summary.tsv	Tue Mar 16 12:38:42 2021 +0000
@@ -0,0 +1,155 @@
+input_file_name	gene_symbol	gene_name	reference_database_id	reference_database_version	reference_accession	analysis_software_name	analysis_software_version	sequence_identity	input_sequence_id	input_protein_start	input_protein_stop	input_gene_start	input_gene_stop	reference_protein_start	reference_protein_stop	reference_gene_start	reference_gene_stop	strand_orientation	coverage_depth	coverage_percentage	coverage_ratio	reference_gene_length	reference_protein_length	input_gene_length	input_protein_length	drug_class	antimicrobial_agent	resistance_mechanism
+GCF_010120755.1_ASM1012075v1_genomic	aacA-ENT1	aminoglycoside 6'-N-acetyltransferase	ncbi	db_v_1	NG_052371.1	abricate	tool_v_1	100.0	NZ_CP039729.1			2163439	2163987					-		100.0						AMINOGLYCOSIDE		
+GCF_010120755.1_ASM1012075v1_genomic	aacA-ENT1	aminoglycoside 6'-N-acetyltransferase	ncbi	db_v_1	NG_052371.1	abricate	tool_v_1	100.0	NZ_CP039729.1			2163439	2163987					-		100.0						AMINOGLYCOSIDE		
+GCF_010120755.1_ASM1012075v1_genomic	eat(A)	ABC-F type ribosomal protection protein Eat(A)	ncbi	db_v_1	NG_047762.1	abricate	tool_v_1	100.0	NZ_CP039729.1			656118	657620					+		100.0						PLEUROMUTILIN		
+GCF_010120755.1_ASM1012075v1_genomic	eat(A)	ABC-F type ribosomal protection protein Eat(A)	ncbi	db_v_1	NG_047762.1	abricate	tool_v_1	100.0	NZ_CP039729.1			656118	657620					+		100.0						PLEUROMUTILIN		
+GCF_010120755.1_ASM1012075v1_genomic	msr(C)	ABC-F type ribosomal protection protein Msr(C)	ncbi	db_v_1	NG_048003.1	abricate	tool_v_1	98.92	NZ_CP039729.1			2564038	2565516					-		100.0						MACROLIDE		
+GCF_010120755.1_ASM1012075v1_genomic	msr(C)	ABC-F type ribosomal protection protein Msr(C)	ncbi	db_v_1	NG_048003.1	abricate	tool_v_1	98.92	NZ_CP039729.1			2564038	2565516					-		100.0						MACROLIDE		
+GCF_010120755.1_ASM1012075v1_genomic	vanH-M	D-lactate dehydrogenase VanH-M	ncbi	db_v_1	NG_048388.1	abricate	tool_v_1	100.0	NZ_CP039730.1			45227	46207					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanH-M	D-lactate dehydrogenase VanH-M	ncbi	db_v_1	NG_048388.1	abricate	tool_v_1	100.0	NZ_CP039730.1			45227	46207					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanM	D-alanine--(R)-lactate ligase VanM	ncbi	db_v_1	NG_048396.1	abricate	tool_v_1	100.0	NZ_CP039730.1			44203	45234					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanM	D-alanine--(R)-lactate ligase VanM	ncbi	db_v_1	NG_048396.1	abricate	tool_v_1	100.0	NZ_CP039730.1			44203	45234					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanS-M	VanM-type vancomycin resistance histidine kinase VanS	ncbi	db_v_1	NG_048450.1	abricate	tool_v_1	100.0	NZ_CP039730.1			47306	48418					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanS-M	VanM-type vancomycin resistance histidine kinase VanS	ncbi	db_v_1	NG_048450.1	abricate	tool_v_1	100.0	NZ_CP039730.1			47306	48418					-		100.0						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanX-M	D-Ala-D-Ala dipeptidase VanX-M	ncbi	db_v_1	NG_048495.1	abricate	tool_v_1	100.0	NZ_CP039730.1			43619	44197					-		95.07						VANCOMYCIN		
+GCF_010120755.1_ASM1012075v1_genomic	vanX-M	D-Ala-D-Ala dipeptidase VanX-M	ncbi	db_v_1	NG_048495.1	abricate	tool_v_1	100.0	NZ_CP039730.1			43619	44197					-		95.07						VANCOMYCIN		
+ariba_report	AAC_3__IId	AAC_3__IId.3004623.EU022314.1.0_861.5344	dbname	db_v_1	AAC_3__IId.3004623.EU022314.1.0_861.5344	ariba	ariba_v1	99.88	AAC_3__II-.l15.c4.ctg.1										37.8			861						
+ariba_report	AAC_3__IId	AAC_3__IId.3004623.EU022314.1.0_861.5344	dbname	db_v_1	AAC_3__IId.3004623.EU022314.1.0_861.5344	ariba	ariba_v1	99.88	AAC_3__II-.l15.c4.ctg.1										37.8			861						
+ariba_report	AAC_6___Ib4	AAC_6___Ib4.3002577.AF445082.2788_3343.401	dbname	db_v_1	AAC_6___Ib4.3002577.AF445082.2788_3343.401	ariba	ariba_v1	99.64	AAC_6___Ib+.l15.c30.ctg.1										128.1			555						
+ariba_report	AAC_6___Ib4	AAC_6___Ib4.3002577.AF445082.2788_3343.401	dbname	db_v_1	AAC_6___Ib4.3002577.AF445082.2788_3343.401	ariba	ariba_v1	99.64	AAC_6___Ib+.l15.c30.ctg.1										128.1			555						
+ariba_report	BRP_MBL_	BRP_MBL_.3001205.KC503911.1.9883_10249.5446	dbname	db_v_1	BRP_MBL_.3001205.KC503911.1.9883_10249.5446	ariba	ariba_v1	100.0	BRP_MBL_.l6.c4.ctg.1										27.3			366						
+ariba_report	BRP_MBL_	BRP_MBL_.3001205.KC503911.1.9883_10249.5446	dbname	db_v_1	BRP_MBL_.3001205.KC503911.1.9883_10249.5446	ariba	ariba_v1	100.0	BRP_MBL_.l6.c4.ctg.1										27.3			366						
+ariba_report	CRP	CRP.3000518.AP009048.1.4153663_4154296.4752	dbname	db_v_1	CRP.3000518.AP009048.1.4153663_4154296.4752	ariba	ariba_v1	93.84	CRP.l15.c4.ctg.1										24.1			633						
+ariba_report	CRP	CRP.3000518.AP009048.1.4153663_4154296.4752	dbname	db_v_1	CRP.3000518.AP009048.1.4153663_4154296.4752	ariba	ariba_v1	93.84	CRP.l15.c4.ctg.1										24.1			633						
+ariba_report	CTX_M_15	CTX_M_15.3001878.AY044436.1435_2311.1430	dbname	db_v_1	CTX_M_15.3001878.AY044436.1435_2311.1430	ariba	ariba_v1	100.0	CTX_M_-.l15.c4.ctg.1										36.0			876						
+ariba_report	CTX_M_15	CTX_M_15.3001878.AY044436.1435_2311.1430	dbname	db_v_1	CTX_M_15.3001878.AY044436.1435_2311.1430	ariba	ariba_v1	100.0	CTX_M_-.l15.c4.ctg.1										36.0			876						
+ariba_report	DHA_7	DHA_7.3002136.HQ456945.0_1140.1865	dbname	db_v_1	DHA_7.3002136.HQ456945.0_1140.1865	ariba	ariba_v1	100.0	DHA_-.l15.c4.ctg.1										29.8			1140						
+ariba_report	DHA_7	DHA_7.3002136.HQ456945.0_1140.1865	dbname	db_v_1	DHA_7.3002136.HQ456945.0_1140.1865	ariba	ariba_v1	100.0	DHA_-.l15.c4.ctg.1										29.8			1140						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_23S	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	dbname	db_v_1	Escherichia_coli_23S.3004173.AE014075.1.237159_240063.4164	ariba	ariba_v1	97.1	Escherichia_coli_23S.l15.c17.ctg.1										611.4			2904						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_EF_Tu	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	dbname	db_v_1	Escherichia_coli_EF_Tu.3003370.U00096.3.3470144_3471329.5280	ariba	ariba_v1	96.12	Escherichia_coli_EF_Tu.l15.c30.ctg.1										106.2			1185						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	Escherichia_coli_PtsI	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	dbname	db_v_1	Escherichia_coli_PtsI.3003899.HG738867.2416338_2418066.3675	ariba	ariba_v1	91.64	Escherichia_coli_PtsI.l15.c4.ctg.2										23.5			1728						
+ariba_report	FosA6	FosA6.3004111.KU254579.1.59421_59841.4755	dbname	db_v_1	FosA6.3004111.KU254579.1.59421_59841.4755	ariba	ariba_v1	98.81	FosA-_1.l15.c4.ctg.1										27.2			420						
+ariba_report	FosA6	FosA6.3004111.KU254579.1.59421_59841.4755	dbname	db_v_1	FosA6.3004111.KU254579.1.59421_59841.4755	ariba	ariba_v1	98.81	FosA-_1.l15.c4.ctg.1										27.2			420						
+ariba_report	H_NS	H_NS.3000676.BA000007.3.1737690_1738104.5476	dbname	db_v_1	H_NS.3000676.BA000007.3.1737690_1738104.5476	ariba	ariba_v1	93.69	H_NS.l15.c4.ctg.1										20.6			414						
+ariba_report	H_NS	H_NS.3000676.BA000007.3.1737690_1738104.5476	dbname	db_v_1	H_NS.3000676.BA000007.3.1737690_1738104.5476	ariba	ariba_v1	93.69	H_NS.l15.c4.ctg.1										20.6			414						
+ariba_report	Klebsiella_mutant_PhoP	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	dbname	db_v_1	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	ariba	ariba_v1	100.0	Klebsiella_mutant_PhoP.l6.c4.ctg.1										48.2			672						
+ariba_report	Klebsiella_mutant_PhoP	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	dbname	db_v_1	Klebsiella_mutant_PhoP.3003585.FO834906.1.2325636_2326308.4715	ariba	ariba_v1	100.0	Klebsiella_mutant_PhoP.l6.c4.ctg.1										48.2			672						
+ariba_report	Klebsiella_pneumoniae_KpnE	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	dbname	db_v_1	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	ariba	ariba_v1	99.45	Klebsiella_pneumoniae_KpnE.l15.c4.ctg.1										56.7			363						
+ariba_report	Klebsiella_pneumoniae_KpnE	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	dbname	db_v_1	Klebsiella_pneumoniae_KpnE.3004580.AP006725.1.2483889_2484252.5313	ariba	ariba_v1	99.45	Klebsiella_pneumoniae_KpnE.l15.c4.ctg.1										56.7			363						
+ariba_report	Klebsiella_pneumoniae_KpnF	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	dbname	db_v_1	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_KpnF.l15.c4.ctg.1										45.9			330						
+ariba_report	Klebsiella_pneumoniae_KpnF	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	dbname	db_v_1	Klebsiella_pneumoniae_KpnF.3004583.AP006725.1.2484238_2484568.5312	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_KpnF.l15.c4.ctg.1										45.9			330						
+ariba_report	Klebsiella_pneumoniae_KpnG	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	dbname	db_v_1	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	ariba	ariba_v1	99.32	Klebsiella_pneumoniae_KpnG.l15.c4.ctg.1										66.3			1173						
+ariba_report	Klebsiella_pneumoniae_KpnG	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	dbname	db_v_1	Klebsiella_pneumoniae_KpnG.3004588.ACWO01000051.1.22092_23265.5311	ariba	ariba_v1	99.32	Klebsiella_pneumoniae_KpnG.l15.c4.ctg.1										66.3			1173						
+ariba_report	Klebsiella_pneumoniae_OmpK35	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	dbname	db_v_1	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_OmpK35.l15.c4.ctg.1										66.2			684						
+ariba_report	Klebsiella_pneumoniae_OmpK35	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	dbname	db_v_1	Klebsiella_pneumoniae_OmpK35.3003966.NC_016845.1.1904307_1904991.5852	ariba	ariba_v1	100.0	Klebsiella_pneumoniae_OmpK35.l15.c4.ctg.1										66.2			684						
+ariba_report	Klebsiella_pneumoniae_OmpK36	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	dbname	db_v_1	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	ariba	ariba_v1	99.82	Klebsiella_pneumoniae_OmpK36.l15.c4.ctg.1										74.2			1104						
+ariba_report	Klebsiella_pneumoniae_OmpK36	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	dbname	db_v_1	Klebsiella_pneumoniae_OmpK36.3003968.NC_016845.1.3727881_3728985.5853	ariba	ariba_v1	99.82	Klebsiella_pneumoniae_OmpK36.l15.c4.ctg.1										74.2			1104						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	Klebsiella_pneumoniae_OmpK37	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	dbname	db_v_1	Klebsiella_pneumoniae_OmpK37.3004122.AJ011502.1.300_1425.4406	ariba	ariba_v1	95.5	Klebsiella_pneumoniae_OmpK37.l6.c4.ctg.1										66.2			1125						
+ariba_report	NDM_1	NDM_1.3000589.FN396876.2406_3219.4450	dbname	db_v_1	NDM_1.3000589.FN396876.2406_3219.4450	ariba	ariba_v1	100.0	NDM_-.l15.c4.ctg.1										27.2			813						
+ariba_report	NDM_1	NDM_1.3000589.FN396876.2406_3219.4450	dbname	db_v_1	NDM_1.3000589.FN396876.2406_3219.4450	ariba	ariba_v1	100.0	NDM_-.l15.c4.ctg.1										27.2			813						
+ariba_report	OXA_1	OXA_1.3001396.JN420336.1.1399_2230.4668	dbname	db_v_1	OXA_1.3001396.JN420336.1.1399_2230.4668	ariba	ariba_v1	100.0	OXA_-_3.l15.c4.ctg.1										22.5			831						
+ariba_report	OXA_1	OXA_1.3001396.JN420336.1.1399_2230.4668	dbname	db_v_1	OXA_1.3001396.JN420336.1.1399_2230.4668	ariba	ariba_v1	100.0	OXA_-_3.l15.c4.ctg.1										22.5			831						
+ariba_report	SHV_182	SHV_182.3001364.KP050489.0_861.2124	dbname	db_v_1	SHV_182.3001364.KP050489.0_861.2124	ariba	ariba_v1	99.88	SHV_-.l15.c4.ctg.1										41.0			861						
+ariba_report	SHV_182	SHV_182.3001364.KP050489.0_861.2124	dbname	db_v_1	SHV_182.3001364.KP050489.0_861.2124	ariba	ariba_v1	99.88	SHV_-.l15.c4.ctg.1										41.0			861						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrA	acrA.3004041.AJ318073.1.793_1990.3994	dbname	db_v_1	acrA.3004041.AJ318073.1.793_1990.3994	ariba	ariba_v1	97.74	acrA.l15.c4.ctg.1										61.7			1197						
+ariba_report	acrA	acrA.3004042.DQ679966.299_1493.3995	dbname	db_v_1	acrA.3004042.DQ679966.299_1493.3995	ariba	ariba_v1	91.19	acrA_1.l15.c4.ctg.1										20.0			1194						
+ariba_report	acrR	acrR.3003373.CP000647.489264_489915.2069	dbname	db_v_1	acrR.3003373.CP000647.489264_489915.2069	ariba	ariba_v1	99.85	acrR.l6.c4.ctg.1										65.8			651						
+ariba_report	acrR	acrR.3003373.CP000647.489264_489915.2069	dbname	db_v_1	acrR.3003373.CP000647.489264_489915.2069	ariba	ariba_v1	99.85	acrR.l6.c4.ctg.1										65.8			651						
+ariba_report	catB3	catB3.3002676.JX101693.1.58200_58833.5450	dbname	db_v_1	catB3.3002676.JX101693.1.58200_58833.5450	ariba	ariba_v1	100.0	catB3.l15.c4.ctg.1										31.5			633						
+ariba_report	catB3	catB3.3002676.JX101693.1.58200_58833.5450	dbname	db_v_1	catB3.3002676.JX101693.1.58200_58833.5450	ariba	ariba_v1	100.0	catB3.l15.c4.ctg.1										31.5			633						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	fabG	fabG.3004049.U00096.3.1150669_1151404.5523	dbname	db_v_1	fabG.3004049.U00096.3.1150669_1151404.5523	ariba	ariba_v1	92.27	fabG.l15.c4.ctg.1										12.3			735						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3004334.AE006468.2.2373709_2376346.5394	dbname	db_v_1	gyrA.3004334.AE006468.2.2373709_2376346.5394	ariba	ariba_v1	92.44	gyrA_8.l15.c4.ctg.2										6.7			2637						
+ariba_report	gyrA	gyrA.3003940.AE005674.2.2352231_2354859.5265	dbname	db_v_1	gyrA.3003940.AE005674.2.2352231_2354859.5265	ariba	ariba_v1	92.71	gyrA_9.l6.c17.ctg.2										40.9			2628						
+ariba_report	gyrA	gyrA.3004334.AE006468.2.2373709_2376346.5394	dbname	db_v_1	gyrA.3004334.AE006468.2.2373709_2376346.5394	ariba	ariba_v1	92.44	gyrA_8.l15.c4.ctg.2										6.7			2637						
+ariba_report	oqxA	oqxA.3003922.EU370913.1.46651_47827.5460	dbname	db_v_1	oqxA.3003922.EU370913.1.46651_47827.5460	ariba	ariba_v1	99.23	oqxA.l6.c4.ctg.1										55.6			1176						
+ariba_report	oqxA	oqxA.3003922.EU370913.1.46651_47827.5460	dbname	db_v_1	oqxA.3003922.EU370913.1.46651_47827.5460	ariba	ariba_v1	99.23	oqxA.l6.c4.ctg.1										55.6			1176						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	oqxB	oqxB.3003923.EU370913.1.47850_51003.5462	dbname	db_v_1	oqxB.3003923.EU370913.1.47850_51003.5462	ariba	ariba_v1	98.86	oqxB.l15.c4.ctg.1										57.2			3153						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	ramR	ramR.3003380.CP000647.1.622039_622621.4572	dbname	db_v_1	ramR.3003380.CP000647.1.622039_622621.4572	ariba	ariba_v1	100.0	ramR_1.l15.c4.ctg.1										53.5			582						
+ariba_report	rmtC	rmtC.3000861.KJ476816.1.79_925.3396	dbname	db_v_1	rmtC.3000861.KJ476816.1.79_925.3396	ariba	ariba_v1	100.0	rmtC.l15.c17.ctg.1										36.8			846						
+ariba_report	rmtC	rmtC.3000861.KJ476816.1.79_925.3396	dbname	db_v_1	rmtC.3000861.KJ476816.1.79_925.3396	ariba	ariba_v1	100.0	rmtC.l15.c17.ctg.1										36.8			846						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	94.08	rpoB.l15.c4.ctg.1										30.1			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	94.08	rpoB.l15.c4.ctg.1										30.1			4029						
+ariba_report	rpoB	rpoB.3003288.BA000007.3.4990267_4994296.5493	dbname	db_v_1	rpoB.3003288.BA000007.3.4990267_4994296.5493	ariba	ariba_v1	93.44	rpoB.l15.c4.ctg.2										33.7			4029						
+ariba_report	rrsD	rrsD.3003512.AE006468.3570463_3572006.3227	dbname	db_v_1	rrsD.3003512.AE006468.3570463_3572006.3227	ariba	ariba_v1	97.22	rrsB+.l15.c17.ctg.1										765.7			1544						
+ariba_report	rrsD	rrsD.3003512.AE006468.3570463_3572006.3227	dbname	db_v_1	rrsD.3003512.AE006468.3570463_3572006.3227	ariba	ariba_v1	97.22	rrsB+.l15.c17.ctg.1										765.7			1544						
+ariba_report	sul1	sul1.3000410.JF969163.1053_1893.340	dbname	db_v_1	sul1.3000410.JF969163.1053_1893.340	ariba	ariba_v1	99.88	sul1.l15.c17.ctg.1										43.9			840						
+ariba_report	sul1	sul1.3000410.JF969163.1053_1893.340	dbname	db_v_1	sul1.3000410.JF969163.1053_1893.340	ariba	ariba_v1	99.88	sul1.l15.c17.ctg.1										43.9			840						
+rgi_report	AAC(3)-IId	AAC(3)	CARD	card_v1	3004623	rgi	rgi_v1	100.0	NODE_39_length_11164_cov_23.0187_6			4569	5429					+		100.0						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(3)-IId	AAC(3)	CARD	card_v1	3004623	rgi	rgi_v1	100.0	NODE_39_length_11164_cov_23.0187_6			4569	5429					+		100.0						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	95.45	NODE_54_length_1272_cov_25.1921_2 			1130	1270					+		23.62						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	100.0	NODE_185_length_335_cov_33.8077_1 			172	333					+		27.14						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	95.45	NODE_54_length_1272_cov_25.1921_2 			1130	1270					+		23.62						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib-cr	AAC(6')	CARD	card_v1	3002547	rgi	rgi_v1	100.0	NODE_185_length_335_cov_33.8077_1 			172	333					+		27.14						fluoroquinolone antibiotic; aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib10	AAC(6')	CARD	card_v1	3002581	rgi	rgi_v1	100.0	NODE_69_length_625_cov_55.4398_1			63	623					-		91.63						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	AAC(6')-Ib10	AAC(6')	CARD	card_v1	3002581	rgi	rgi_v1	100.0	NODE_69_length_625_cov_55.4398_1			63	623					-		91.63						aminoglycoside antibiotic		antibiotic inactivation
+rgi_report	BRP(MBL)	Bleomycin resistant protein	CARD	card_v1	3001205	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_2 			1222	1482					+		71.07						glycopeptide antibiotic		antibiotic inactivation
+rgi_report	BRP(MBL)	Bleomycin resistant protein	CARD	card_v1	3001205	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_2 			1222	1482					+		71.07						glycopeptide antibiotic		antibiotic inactivation
+rgi_report	CBP-1	CBP beta-lactamase	CARD	card_v1	3004764	rgi	rgi_v1	100.0	NODE_19_length_86672_cov_43.8582_38 			39587	39811					-		24.03						penam		antibiotic inactivation
+rgi_report	CBP-1	CBP beta-lactamase	CARD	card_v1	3004764	rgi	rgi_v1	100.0	NODE_19_length_86672_cov_43.8582_38 			39587	39811					-		24.03						penam		antibiotic inactivation
+rgi_report	CRP	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000518	rgi	rgi_v1	99.05	NODE_9_length_203843_cov_42.4911_20			15303	15935					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; penam		antibiotic efflux
+rgi_report	CRP	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000518	rgi	rgi_v1	99.05	NODE_9_length_203843_cov_42.4911_20			15303	15935					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; penam		antibiotic efflux
+rgi_report	CTX-M-15	CTX-M beta-lactamase	CARD	card_v1	3001878	rgi	rgi_v1	100.0	NODE_47_length_3813_cov_27.9457_4			2763	3638					-		100.0						cephalosporin		antibiotic inactivation
+rgi_report	CTX-M-15	CTX-M beta-lactamase	CARD	card_v1	3001878	rgi	rgi_v1	100.0	NODE_47_length_3813_cov_27.9457_4			2763	3638					-		100.0						cephalosporin		antibiotic inactivation
+rgi_report	DHA-7	DHA beta-lactamase	CARD	card_v1	3002136	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_3 			1846	2862					-		89.18						cephalosporin; cephamycin		antibiotic inactivation
+rgi_report	DHA-7	DHA beta-lactamase	CARD	card_v1	3002136	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_3 			1846	2862					-		89.18						cephalosporin; cephamycin		antibiotic inactivation
+rgi_report	Escherichia coli ampH beta-lactamase	ampC-type beta-lactamase	CARD	card_v1	3004612	rgi	rgi_v1	85.71	NODE_6_length_262587_cov_42.4347_234			216120	217280					+		100.26						cephalosporin; penam		antibiotic inactivation
+rgi_report	Escherichia coli ampH beta-lactamase	ampC-type beta-lactamase	CARD	card_v1	3004612	rgi	rgi_v1	85.71	NODE_6_length_262587_cov_42.4347_234			216120	217280					+		100.26						cephalosporin; penam		antibiotic inactivation
+rgi_report	Escherichia coli mdfA	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3001328	rgi	rgi_v1	85.61	NODE_21_length_66123_cov_41.3566_52			60858	62090					+		100.0						tetracycline antibiotic; benzalkonium chloride; rhodamine		antibiotic efflux
+rgi_report	Escherichia coli mdfA	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3001328	rgi	rgi_v1	85.61	NODE_21_length_66123_cov_41.3566_52			60858	62090					+		100.0						tetracycline antibiotic; benzalkonium chloride; rhodamine		antibiotic efflux
+rgi_report	FosA6	fosfomycin thiol transferase	CARD	card_v1	3004111	rgi	rgi_v1	97.84	NODE_4_length_367278_cov_42.3139_12			14037	14456					+		100.0						fosfomycin		antibiotic inactivation
+rgi_report	FosA6	fosfomycin thiol transferase	CARD	card_v1	3004111	rgi	rgi_v1	97.84	NODE_4_length_367278_cov_42.3139_12			14037	14456					+		100.0						fosfomycin		antibiotic inactivation
+rgi_report	Klebsiella pneumoniae KpnE	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004580	rgi	rgi_v1	99.17	NODE_27_length_37761_cov_37.6839_21			25311	25673					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnE	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004580	rgi	rgi_v1	99.17	NODE_27_length_37761_cov_37.6839_21			25311	25673					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnF	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004583	rgi	rgi_v1	100.0	NODE_27_length_37761_cov_37.6839_22			25660	25989					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnF	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004583	rgi	rgi_v1	100.0	NODE_27_length_37761_cov_37.6839_22			25660	25989					+		100.0						macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnG	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004588	rgi	rgi_v1	99.74	NODE_1_length_803036_cov_42.265_81			80036	81208					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnG	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004588	rgi	rgi_v1	99.74	NODE_1_length_803036_cov_42.265_81			80036	81208					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnH	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004597	rgi	rgi_v1	94.02	NODE_1_length_803036_cov_42.265_82			81224	82762					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	Klebsiella pneumoniae KpnH	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3004597	rgi	rgi_v1	94.02	NODE_1_length_803036_cov_42.265_82			81224	82762					+		100.0						macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem		antibiotic efflux
+rgi_report	Klebsiella pneumoniae acrA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3004041	rgi	rgi_v1	95.24	NODE_6_length_262587_cov_42.4347_106 			86156	87349					+		99.75						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	Klebsiella pneumoniae acrA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3004041	rgi	rgi_v1	95.24	NODE_6_length_262587_cov_42.4347_106 			86156	87349					+		99.75						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	NDM-1	NDM beta-lactamase	CARD	card_v1	3000589	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_1			301	1113					+		100.0						carbapenem; cephalosporin; cephamycin; penam		antibiotic inactivation
+rgi_report	NDM-1	NDM beta-lactamase	CARD	card_v1	3000589	rgi	rgi_v1	100.0	NODE_44_length_4295_cov_23.2123_1			301	1113					+		100.0						carbapenem; cephalosporin; cephamycin; penam		antibiotic inactivation
+rgi_report	OXA-1	OXA beta-lactamase	CARD	card_v1	3001396	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_1			196	1026					+		100.0						cephalosporin; penam		antibiotic inactivation
+rgi_report	OXA-1	OXA beta-lactamase	CARD	card_v1	3001396	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_1			196	1026					+		100.0						cephalosporin; penam		antibiotic inactivation
+rgi_report	PmrF	pmr phosphoethanolamine transferase	CARD	card_v1	3003578	rgi	rgi_v1	83.69	NODE_9_length_203843_cov_42.4911_123			130217	131200					-		101.55						peptide antibiotic		antibiotic target alteration
+rgi_report	PmrF	pmr phosphoethanolamine transferase	CARD	card_v1	3003578	rgi	rgi_v1	83.69	NODE_9_length_203843_cov_42.4911_123			130217	131200					-		101.55						peptide antibiotic		antibiotic target alteration
+rgi_report	SHV-11	SHV beta-lactamase	CARD	card_v1	3001070	rgi	rgi_v1	100.0	NODE_11_length_157792_cov_39.2115_132			128890	129750					+		100.0						carbapenem; cephalosporin; penam		antibiotic inactivation
+rgi_report	SHV-11	SHV beta-lactamase	CARD	card_v1	3001070	rgi	rgi_v1	100.0	NODE_11_length_157792_cov_39.2115_132			128890	129750					+		100.0						carbapenem; cephalosporin; penam		antibiotic inactivation
+rgi_report	acrB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000216	rgi	rgi_v1	91.52	NODE_6_length_262587_cov_42.4347_107			87372	90518					+		99.9						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	acrB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000216	rgi	rgi_v1	91.52	NODE_6_length_262587_cov_42.4347_107			87372	90518					+		99.9						fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan		antibiotic efflux
+rgi_report	acrD	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000491	rgi	rgi_v1	90.94	NODE_3_length_454317_cov_40.2449_285			330238	333351					+		100.0						aminoglycoside antibiotic		antibiotic efflux
+rgi_report	acrD	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000491	rgi	rgi_v1	90.94	NODE_3_length_454317_cov_40.2449_285			330238	333351					+		100.0						aminoglycoside antibiotic		antibiotic efflux
+rgi_report	baeR	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000828	rgi	rgi_v1	90.83	NODE_3_length_454317_cov_40.2449_18			26745	27467					+		100.0						aminoglycoside antibiotic; aminocoumarin antibiotic		antibiotic efflux
+rgi_report	baeR	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000828	rgi	rgi_v1	90.83	NODE_3_length_454317_cov_40.2449_18			26745	27467					+		100.0						aminoglycoside antibiotic; aminocoumarin antibiotic		antibiotic efflux
+rgi_report	catB3	chloramphenicol acetyltransferase (CAT)	CARD	card_v1	3002676	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_2 			1164	1712					+		86.67						phenicol antibiotic		antibiotic inactivation
+rgi_report	catB3	chloramphenicol acetyltransferase (CAT)	CARD	card_v1	3002676	rgi	rgi_v1	100.0	NODE_51_length_1731_cov_22.5767_2 			1164	1712					+		86.67						phenicol antibiotic		antibiotic inactivation
+rgi_report	emrR	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3000516	rgi	rgi_v1	92.57	NODE_1_length_803036_cov_42.265_80			79380	79910					+		100.0						fluoroquinolone antibiotic		antibiotic efflux
+rgi_report	emrR	major facilitator superfamily (MFS) antibiotic efflux pump	CARD	card_v1	3000516	rgi	rgi_v1	92.57	NODE_1_length_803036_cov_42.265_80			79380	79910					+		100.0						fluoroquinolone antibiotic		antibiotic efflux
+rgi_report	marA	resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams	CARD	card_v1	3000263	rgi	rgi_v1	92.74	NODE_11_length_157792_cov_39.2115_112			108413	108787					+		97.64						fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan; penem		antibiotic efflux; reduced permeability to antibiotic
+rgi_report	marA	resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams	CARD	card_v1	3000263	rgi	rgi_v1	92.74	NODE_11_length_157792_cov_39.2115_112			108413	108787					+		97.64						fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; triclosan; penem		antibiotic efflux; reduced permeability to antibiotic
+rgi_report	mdtB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000793	rgi	rgi_v1	90.1	NODE_3_length_454317_cov_40.2449_14			17656	20778					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	mdtB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000793	rgi	rgi_v1	90.1	NODE_3_length_454317_cov_40.2449_14			17656	20778					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	mdtC	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000794	rgi	rgi_v1	91.41	NODE_3_length_454317_cov_40.2449_15			20779	23856					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	mdtC	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3000794	rgi	rgi_v1	91.41	NODE_3_length_454317_cov_40.2449_15			20779	23856					+		100.0						aminocoumarin antibiotic		antibiotic efflux
+rgi_report	msbA	ATP-binding cassette (ABC) antibiotic efflux pump	CARD	card_v1	3003950	rgi	rgi_v1	92.78	NODE_8_length_247415_cov_40.5207_219			227800	229548					-		100.0						nitroimidazole antibiotic		antibiotic efflux
+rgi_report	msbA	ATP-binding cassette (ABC) antibiotic efflux pump	CARD	card_v1	3003950	rgi	rgi_v1	92.78	NODE_8_length_247415_cov_40.5207_219			227800	229548					-		100.0						nitroimidazole antibiotic		antibiotic efflux
+rgi_report	oqxA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003922	rgi	rgi_v1	100.0	NODE_1_length_803036_cov_42.265_33			30758	31933					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	oqxA	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003922	rgi	rgi_v1	100.0	NODE_1_length_803036_cov_42.265_33			30758	31933					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	oqxB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003923	rgi	rgi_v1	99.52	NODE_1_length_803036_cov_42.265_34			31957	35109					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	oqxB	resistance-nodulation-cell division (RND) antibiotic efflux pump	CARD	card_v1	3003923	rgi	rgi_v1	99.52	NODE_1_length_803036_cov_42.265_34			31957	35109					+		100.0						fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic		antibiotic efflux
+rgi_report	rmtC	16S rRNA methyltransferase (G1405)	CARD	card_v1	3000861	rgi	rgi_v1	100.0	NODE_40_length_7360_cov_24.8738_6			6358	7203					-		100.0						aminoglycoside antibiotic		antibiotic target alteration
+rgi_report	rmtC	16S rRNA methyltransferase (G1405)	CARD	card_v1	3000861	rgi	rgi_v1	100.0	NODE_40_length_7360_cov_24.8738_6			6358	7203					-		100.0						aminoglycoside antibiotic		antibiotic target alteration
+rgi_report	sul1	sulfonamide resistant sul	CARD	card_v1	3000410	rgi	rgi_v1	100.0	NODE_57_length_1134_cov_34.8908_1			25	864					-		100.0						sulfonamide antibiotic		antibiotic target replacement
+rgi_report	sul1	sulfonamide resistant sul	CARD	card_v1	3000410	rgi	rgi_v1	100.0	NODE_57_length_1134_cov_34.8908_1			25	864					-		100.0						sulfonamide antibiotic		antibiotic target replacement